CN104983806A - Traditional Chinese medicine composition for treating oral diseases, preparation method, and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating oral diseases, preparation method, and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating oral diseases, a preparation method, and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 0.1-20 parts of an Americana linn extract and 0.1-10 parts of long pepper. The traditional Chinese medicine composition has the advantages that the Americana linn extract and the long pepper are combined; the Americana linn extract is high in muscle tissue repairing activity, and can be utilized for promoting oral ulcer healing; the long pepper has an antibacterial effect, and can be utilized for inhibiting nerve endings from transmitting pain signals, so as to relieve pain and reduce oral problems caused by hypersensitivity; the efficacies of the Americana linn extract and the long pepper are jointly exerted for treating oral ulcer and hemodia effectively, so that the ulcer healing rate can be improved and the ulcer healing period can be shortened; the Americana linn extract and the long pepper have the main acting mechanisms for promoting tissue regeneration to stop bleeding, promoting wound healing, and inhibiting oral bacteria, so that the treatment can be achieved fundamentally, various immune functions of a human body are protected from damage, and the traditional Chinese medicine composition is suitable of long-term use; the Americana linn extract and the long pepper are relatively common medicines, so that the traditional Chinese medicine composition is relatively low in cost and convenient to popularize.
Description
Technical field
The invention belongs to the technical field of medical science, particularly relate to and a kind ofly treat the Chinese medicine composition of oral ulcer and anti-sensitivity of tooth and the application in oral care implement thereof.
Background technology
Oral ulcer, is among the peoplely generally referred to as " getting angry in oral cavity " or " aphtha ", the sex-limited ulcerative lesions of oral mucosa office oral ulcer of feature that to be a kind of with periodic flare be, can spontaneous recovery, can occur in any position of oral mucosa.At present, the cause of disease of oral ulcer and mechanism of causing a disease still indefinite.The inducement of oral ulcer may be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency.Because the course of disease is grown and pain, often make troubles to patient and misery.
Sensitivity of tooth, that tooth is being subject to environmental stimuli, symptom of aching as caused in temperature (hot and cold), chemical substance (sour, sweet) and mechanism (rub or sting hard object) etc., its feature is for outbreak is rapid, pain is sharp-pointed, the time is of short duration.All enamel integrity that can make are damaged, the various dental diseases that dentin exposes, and all dentin hypersensitivity can occur as abrasion, wedge shaped defect, odontagma, dental caries and periodontal atrophy cause neck portion exposure etc.
Periplaneta americana is a kind of traditional pharmaceutical insects, and be Blattaria Blattidae Periplaneta insecticide, research shows, periplaneta americana has and promotes blood vessel hyperplasia, tissue repair, strengthening heart and boosting pressure, improves microcirculation, antimicrobial antiphlogistic, antiviral, antitumor, strengthens the effects such as immunity, can be used for skin, oral cavity.Porphyromonas gingivalis is the periodontal disease especially topmost dominant bacteria of adult periodontitis's diseased region, and the medicine of periodontal disease must suppress periodontal pathogen effectively, and Hu Shaopeng etc. confirm that American-cockroach-extract effectively can suppress the growth of porphyromonas gingivalis.Xiao little Qin etc. also demonstrate that American-cockroach-extract has obvious inhibitory action to the tissue edema that inflammation causes with oozing out, and have significant analgesic activity, have anti-inflammation detumescence effect.And the extraction process of American-cockroach-extract is ripe, it also has gratifying prospect in the preventing and treating of periodontal, and can be used for auxiliary treatment stomatitis, oral ulcer, alveolus dry socket, exodontia complication, periodontitis, chronic periapical periodontitis etc.Publication number is that the patent of invention " a kind of toothpaste and preparation method thereof " of CN102846529A also discloses American-cockroach-extract and the application of American-cockroach-extract on toothpaste.
Fructus Piperis Longi is a kind of Chinese medicine, belongs to Piperaceae plant, and it, containing piperine, volatile oil, has analgesia, bacteriostasis.Piperine in Fructus Piperis Longi is woven with destruction to the nerve of housefly and muscle groups, therefore infer, its Neng Shi dentinal tubule teleneuron fiber destruction, disintegrate, neurodegeneration, thus the sensitivity that reduction dentin stimulates to external world, play the effect for the treatment of sensitivity of tooth.At present, mostly the external used medicine for the treatment of dental hypersensitivity is to use chemosynthesis medicine, and the advantage such as Chinese medicine has unique curative effect and toxic and side effects is few, Chinese medicine is used for the treatment of dental hypersensitivity, effectively can makes up the deficiency of the preparations such as fluoride.At present, existing Fructus Piperis Longi is used for the treatment of the pertinent literature report of hemodia, and clinical effectiveness is better.Publication number is that the patent of invention " a kind of Chinese medicine composition of anti-sensitivity of tooth and toothpaste and preparation method " thereof of CN101933977A discloses Chinese medicine composition using Fructus Piperis Longi as main component and toothpaste, has certain effect to treatment sensitivity of tooth.
Periplaneta americana and Fructus Piperis Longi have certain effect when being used alone respectively to the treatment of oral ulcer and dental hypersensitivity, but come from practical application, and its curative effect receives certain restriction.The present inventor guesses whether its reason is because the use of single medicinal material causes its drug effect not perform to the best, Chinese medicine in use, its effect of polyphamaceutic use is better often, therefore the present inventor expects periplaneta americana and Fructus Piperis Longi being carried out Combination application according to a certain ratio, to improve its therapeutic effect.And the present inventor finds that the patient of oral ulcer is also usually along with hemodia.Up to now, at home and abroad there is no report about American-cockroach-extract, the application of Fructus Piperis Longi compositions in the oral-cavity article such as toothpaste, collutory.
Summary of the invention
The invention provides a kind of Chinese medicine composition for the treatment of oral disease, by adding American-cockroach-extract and Fructus Piperis Longi, reaching the object of mutually supplementing, working in coordination with each other, having good therapeutical effect to oral ulcer and sensitivity of tooth.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: a kind of Chinese medicine composition for the treatment of oral disease, its raw material is made up of following mass fraction: American-cockroach-extract is 0.1 ~ 20 part, and Fructus Piperis Longi is 0.1 ~ 10 part.
Present invention employs Chinese medicine to treat oral ulcer and sensitivity of tooth, Chinese medicine is the rarity that Traditional Chinese doctors ' is learnt to read and write, the generation of any disease, evolution are all that paathogenic factor acts on human body, cause that body yin or yang excessly declines partially, the result of zang-fu differentiation functional disorder.Bias of medicine mainly contains four gas, the five tastes, lifting sink-float, mend let out, the aspect such as Gui Jing, toxicity or no toxicity.If state of an illness more complicated, single application is difficult to avoid untoward reaction, often needs to use two kinds and above medicine simultaneously, can strengthen original drug effect, suppress side effect etc., and people has a kind of baffled preference to Chinese medicine.
Compared with prior art, the invention has the advantages that: 1, American-cockroach-extract and Fructus Piperis Longi are combined, American-cockroach-extract has good muscular tissue repairing activity, the healing of oral ulcer can be promoted, Fructus Piperis Longi has antibacterial action, synergism is had with American-cockroach-extract, Fructus Piperis Longi can also suppress the signal of teleneuron conducting pain, alleviating pain, reduce the oral problem that anaphylaxis causes, jointly play effect with American-cockroach-extract, effectively treatment oral ulcer and hemodia, thus raising ulcer healing rate, shorten healing.2, American-cockroach-extract and the main mechanism of action of Fructus Piperis Longi are promoting regeneration of the tissue and arresting bleeding, promote wound healing and suppress oral cavity bacterium, can fundamentally treat, can not insulting various immune function, are applicable to life-time service.3, American-cockroach-extract and Fructus Piperis Longi are more common medicine, and cost is lower, are convenient to promote and life-time service.
Detailed description of the invention
Embodiment 1
The present embodiment is contrast test, ordinary toothpaste (first group), the toothpaste (second group) containing American-cockroach-extract, the toothpaste containing Fructus Piperis Longi (the 3rd group) and the toothpaste (the 4th group) containing American-cockroach-extract and Fructus Piperis Longi are contrasted, its formula is as shown in the table:
Table 1
What above-mentioned American-cockroach-extract adopted is periplaneta americana fine powder, and the fineness of periplaneta americana fine powder, more than 200 orders, certainly adopts water extract, the periplaneta americana fine powder of periplaneta americana different parts or the mixing of mentioned component also can be reached same effect.The preparation method of the water extract of adult bombay canary, adopt first soak, decoct again, rear concentrated mode extracts; The preparation method of the alcohol extract of adult bombay canary, the mode of take alcohol to soak, filtering is extracted (using and preparing the same the present embodiment of each embodiment about American-cockroach-extract).Fructus Piperis Longi powder fineness is (the same the present embodiment of each embodiment of the use about Fructus Piperis Longi powder) more than 200 orders.
The preparation method of above-mentioned toothpaste is as follows:
First group
1, first glycerol, sorbitol are added and prepare in container, then add and sodium carboxymethyl cellulose, rapid stirring homogenizing.
2, saccharin sodium, water, sodium lauryl sulfate and sodium benzoate is added successively, and uniform stirring.
3, evacuation adds friction-type silicon dioxide and thickening type silicon dioxide, stirs homogenizing.
4, finally add essence, stir homogenizing, degassed, namely toothpaste complete.
Second group
The preparation method of this group adds adult bombay canary alcohol extract after the step adding saccharin sodium in first group of preparation method.
3rd group
The preparation method of this group adds Fructus Piperis Longi powder after the step adding saccharin sodium in first group of preparation method.
4th group
The preparation method of this group adds adult bombay canary alcohol extract and Fructus Piperis Longi powder successively after the step adding saccharin sodium in first group of preparation method.
Shown in his-and-hers watches 1 four group toothpaste carries out clinical oral test, and 120 are suffered from sensitivity of tooth, the people of oral ulcer is divided into equal four groups at random, and often organizing number is 30.They use the toothpaste of first group, second group, the 3rd group and the 4th group respectively on the basis of daily habits (brush every day twice tooth), and continue one week, result is as shown in table 2.
Table 2
From table 2, we can find out, the 4th group of therapeutic effect is significantly better than the therapeutic effect of first group, second group and the 3rd group.This just illustrates that American-cockroach-extract, Fructus Piperis Longi compositions effectively can treat oral ulcer, alleviate the symptom of sensitivity of tooth.
Embodiment 2
The present embodiment is contrast test, common collutory (first group), the collutory (second group) containing American-cockroach-extract, the collutory containing Fructus Piperis Longi (the 3rd group) and the collutory (the 4th group) containing American-cockroach-extract and Fructus Piperis Longi are contrasted, its formula is as shown in the table:
Table 3
In Fructus Piperis Longi oil, the content of piperine is 50 ~ 65% (the same the present embodiment of each embodiment of the use about Fructus Piperis Longi oil).
The preparation method of above-mentioned collutory is as follows:
First group
1, glycerol, sorbitol, poloxamer, neotame and water are mixed into aqueous phase.
2, essence is slowly added above-mentioned aqueous phase while stirring, filter subpackage, prepared by collutory.
Second group
The preparation method of this group adds American-cockroach-extract after the step adding two dealcoholysis ethanol in first group of preparation method.
3rd group
The preparation method of this group adds Fructus Piperis Longi after the step adding two dealcoholysis ethanol in first group of preparation method.
4th group
The preparation method of this group adds American-cockroach-extract and Fructus Piperis Longi successively after the step adding two dealcoholysis ethanol in first group of preparation method.
Shown in his-and-hers watches 3 four group collutory carries out clinical oral test, and 120 are suffered from sensitivity of tooth, the people of oral ulcer is divided into equal four groups at random, and the number often organized is 30.They use the collutory of first group, second group, the 3rd group and the 4th group respectively on the basis of daily habits (every day gargles three times), and continue one week, result is as shown in the table.
Table 4
From table 4, we can find out, the 4th group of therapeutic effect is significantly better than the therapeutic effect of first group, second group and the 3rd group.This just illustrates that American-cockroach-extract, Fructus Piperis Longi compositions effectively can treat oral ulcer, alleviate the symptom of sensitivity of tooth.
Embodiment 3
Toothpaste component containing American-cockroach-extract and Fructus Piperis Longi is as shown in table 5, table 6 and table 7:
Table 5
Table 6
Table 7
Certainly, in the mastic preparation of toothpaste, wetting agent can also be used alone the one in glycerol, sorbitol, propylene glycol or Polyethylene Glycol, or uses the mixture of its combination in any, mass fraction also can select other numerical value except 10g, 35g, and numerical range is at 10 ~ 70g; Binding agent can use sodium hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan, xanthan gum or carbomer single component or compound, and mass fraction is at 0.1 ~ 10g; Surfactant can use single component or the mixture such as anion, cation, both sexes or non-ionic surface active agent, as the mixture of sodium lauryl sulphate, sodium lauryl sulfate, N-sarcosinate, hydramine, poloxamer etc., sodium lauryl sulphate, sodium lauryl sulfate, amount ranges can be 0.1 ~ 10g; Sweeting agent can use saccharin sodium, it is sweet to sharp teeth, one or more mixing in stevioside, stevioside, xylitol, amount ranges 0.1 ~ 3g, essence can use one or more mixing in Herba Menthae, Oleum Menthae Rotundifoliae, Mentha piperita, anethole, amount ranges 0.1 ~ 5g, antiseptic uses one or more mixture in benzoate, sodium benzoate, methyl hydroxybenzoate, amount ranges 0.1 ~ 2g.More than select to be the routine making toothpaste to select.
Shown in his-and-hers watches 5, table 6 and table 7 27 group collutory carries out clinical oral test, and 270 are suffered from sensitivity of tooth, the people of oral ulcer is divided into equal 27 groups at random, and the number often organized is 10.They use the toothpaste of above-mentioned group of number respectively on the basis of daily habits (every day gargles three times), and continue one week, result is as shown in table 8, table 9 and table 10.
Table 8
Table 9
Table 10
As can be seen from table 8-Biao 10: 1, when the quality of periplaneta americana fine powder is at 0.1-20 gram, the quality of Fructus Piperis Longi oil (in Fructus Piperis Longi oil, the content of piperine is 50 ~ 65%) is when 0.1-10 gram, to oral ulcer and hemodia, there is remission effect preferably, when the mass range of periplaneta americana fine powder and Fructus Piperis Longi oil is when above-mentioned scope is outer, to oral ulcer and the total remission effect of hemodia poor.2, when the quality of periplaneta americana fine powder is at 4-10 gram, Fructus Piperis Longi oil quality when 0.4-1 gram, than the quality of periplaneta americana fine powder at 1-20 gram, the quality of Fructus Piperis Longi oil when 0.1-10 gram, to oral ulcer and the total remission effect of hemodia better.3, when the quality of periplaneta americana fine powder is at 5-7 gram, Fructus Piperis Longi oil quality at 0.5-0.7 gram, and the ratio of periplaneta americana fine powder and Fructus Piperis Longi oil is when being 10:1, the remission effect of other proportionings to oral ulcer and hemodia is greater than to the remission effect of oral ulcer and hemodia.4, when the quality of periplaneta americana fine powder is at 6 grams, Fructus Piperis Longi oil quality 0.6 gram time, effect is optimum.
Embodiment 4
Collutory composition containing American-cockroach-extract and Fructus Piperis Longi is as shown in the table:
Table 11
Table 12
Table 13
Wherein, the fineness of periplaneta americana fine powder is more than 200 orders, and in Fructus Piperis Longi oil, the content of piperine is 50 ~ 65%.
Shown in his-and-hers watches 11-13 27 group collutory carries out clinical oral test, and 270 are suffered from sensitivity of tooth, the people of oral ulcer is divided into equal 27 groups at random, and the number often organized is 10.They use the collutory of above-mentioned group of number respectively on the basis of daily habits (every day gargles three times), and continue one week, result is as shown in the table.
Table 14
Table 15
Table 16
Wherein, the fineness of periplaneta americana fine powder is more than 200 orders, and in Fructus Piperis Longi oil, the content of piperine is 50 ~ 65%.
As can be seen from table 14-16: 1, when the quality of periplaneta americana fine powder is at 0.1-20 gram, the quality of Fructus Piperis Longi oil (in Fructus Piperis Longi oil, the content of piperine is 50 ~ 65%) is when 0.1-10 gram, to oral ulcer and hemodia, there is remission effect preferably, when the mass range of periplaneta americana fine powder and Fructus Piperis Longi oil is when above-mentioned scope is outer, to oral ulcer and the total remission effect of hemodia poor.2, when the quality of periplaneta americana fine powder is at 4-10 gram, Fructus Piperis Longi oil quality when 0.4-1 gram, than the quality of periplaneta americana fine powder at 1-20 gram, the quality of Fructus Piperis Longi oil when 0.1-10 gram, to oral ulcer and the total remission effect of hemodia better.3, when the quality of periplaneta americana fine powder is at 5-7 gram, Fructus Piperis Longi oil quality at 0.5-0.7 gram, and the ratio of periplaneta americana fine powder and Fructus Piperis Longi oil is when being 10:1, the remission effect of other proportionings to oral ulcer and hemodia is greater than to the remission effect of oral ulcer and hemodia.4, when the quality of periplaneta americana fine powder is at 6 grams, Fructus Piperis Longi oil quality 0.6 gram time, effect is optimum.
For a person skilled in the art, toothpaste and collutory are considered the oral-cavity article that technical solution of the present invention is comparatively suitable for, but the present invention is not limited in and is added in toothpaste and collutory, is suitable for too at other oral-cavity articles such as dentifrice, tooth paste or ointment preparation, tooth gel and chewing gum.Without departing from the inventive concept of the premise, can also make some distortion and improvement, these also should be considered as protection scope of the present invention, and these all can not affect effect of the invention process and practical applicability.
Claims (9)
1. treat a Chinese medicine composition for oral disease, it is characterized in that, its raw material is made up of following mass fraction: American-cockroach-extract is 0.1 ~ 20 part, and Fructus Piperis Longi is 0.1 ~ 10 part.
2. the Chinese medicine composition for the treatment of oral disease as claimed in claim 1, it is characterized in that, its raw material is made up of following mass fraction: American-cockroach-extract is 4 ~ 10 parts, and Fructus Piperis Longi is 0.5 ~ 1 part.
3. the Chinese medicine composition for the treatment of oral disease as claimed in claim 2, it is characterized in that, its raw material is made up of following mass fraction: American-cockroach-extract is 5 ~ 7 parts, and Fructus Piperis Longi is 0.5 ~ 0.7 part.
4. the Chinese medicine composition for the treatment of oral disease as claimed in claim 3, it is characterized in that, its raw material is made up of following mass fraction: American-cockroach-extract is 6 parts, and Fructus Piperis Longi is 0.6 part.
5. the Chinese medicine composition of the treatment oral disease according to any one of claim 1-4, it is characterized in that, described American-cockroach-extract comprises one or more mixture in the water extract of periplaneta americana different parts or alcohol extract, periplaneta americana fine powder.
6. containing, for example an oral care implement for the Chinese medicine composition according to any one of claim 1-4, it is characterized in that, comprise toothpaste, collutory, dentifrice, tooth paste or ointment preparation, tooth gel and chewing gum.
7. oral care implement as claimed in claim 6, it is characterized in that, the mastic of described toothpaste also comprises wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water.
8. oral care implement as claimed in claim 6, it is characterized in that, the raw material of described collutory comprises wetting agent, water, sweeting agent, poloxamer and essence.
9. the preparation method of toothpaste in oral care implement as claimed in claim 7, is characterized in that comprising the following steps:
The first step, adds wetting agent, then adds binding agent rapid stirring homogenizing, adds sweeting agent, American-cockroach-extract, Fructus Piperis Longi, surfactant, antiseptic successively, and uniform stirring;
Second step, evacuation adds abrasivus, stirs homogenizing;
3rd step, adds essence, and stir homogenizing, degassed, toothpaste completes.
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| CN108578336A (en) * | 2018-02-13 | 2018-09-28 | 云南宁康生物科技有限公司 | A kind of gargle and preparation method thereof containing American-cockroach-extract |
| CN113456567A (en) * | 2021-04-30 | 2021-10-01 | 唐山青木生物科技有限公司 | Periplaneta americana mouthwash and preparation method thereof |
| CN114376956A (en) * | 2022-02-24 | 2022-04-22 | 四川天福精细化工有限公司 | Spray mouth wash and preparation method thereof |
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