CN103977264A - Anti-inflammatory hemostatic dendrobium officinale fruit toothpaste - Google Patents
Anti-inflammatory hemostatic dendrobium officinale fruit toothpaste Download PDFInfo
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- CN103977264A CN103977264A CN201410147624.6A CN201410147624A CN103977264A CN 103977264 A CN103977264 A CN 103977264A CN 201410147624 A CN201410147624 A CN 201410147624A CN 103977264 A CN103977264 A CN 103977264A
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Abstract
The invention discloses anti-inflammatory hemostatic dendrobium officinale fruit toothpaste, belongs to the field of Chinese herbal medicine auxiliary treatment oral daily necessities. Every 100g of the finished toothpaste body contains 0.2%-4% of an anti-inflammatory hemostatic drug ingredient and a blank matrix toothpaste body; the medicinal ingredient three kinds of traditional Chinese medicine extract powder extracted from three kinds of raw medicines of dendrobium officinale fruit, folium isatidis and radix scutellariae, the mass ratio of the three kinds of traditional Chinese medicine extract powder is 2:1:1. The anti-inflammatory hemostatic dendrobium officinale fruit toothpaste aims at oral problems, especially is anti-inflammatory hemostatic, and is free of toxic and side effects, and the Chinese herbal medicine ingredients can play very good prevention function on gingival bleeding and periodontal disease. Compared with Western medicines, the added Chinese herbal medicine ingredients has the advantages of being natural and safe, the hemostatic effect of the anti-inflammatory hemostatic dendrobium officinale fruit toothpaste is more significant than that of hemostatic toothpaste in the market, and the added folium isatidis and radix scutellariae have anti-inflammatory properties, so that the anti-inflammatory hemostatic dendrobium officinale fruit toothpaste is suitable for the needs of the public.
Description
Technical field
The present invention relates to the daily necessities field in a kind of Chinese herbal medicine auxiliary treatment oral cavity, particularly one has anti-inflammation hemostasia Herba Dendrobii fruit toothpaste.
Background technology
Herba Dendrobii, is China tradition rare Chinese medicine, is described as " first of China's nine large Herba mesonae chinensis ", and among the people just have saying of " there is Radix Ginseng in north, and there is Herba Dendrobii in south ", has medical value out of the ordinary, is that royal noble's of successive dynasties health preserving nourishes treasure.Modern pharmacological research proves, Herba Dendrobii has enhancing immunity, eliminates tumor, suppresses the effects such as cancer, and laryngopharyngeal diseases, gastroenteropathy, cataract, cardiovascular disease, diabetes, tumor etc. are all had to significant curative effect.Few very few of the application of the pharmacological property of now to Herba Dendrobii fruit and effect, the research of the pharmacological property of its hemostasis also not yet occurs with application.
Toothpaste, is the necessary that people live, and along with people's living standard quality improves, has more had health care consciousness, and medicated toothpaste not only can cleaning teeth, also has the preventive and therapeutic effect to odontopathy.The research of medicated toothpaste is day by day generally paid attention to abroad, and development trend is to the future development of prevention, health care, and some toothpaste with some special efficacy are favored by more in market.That Chinese medicine has advantages of is natural, safety and Western medicine is incomparable, and then some functional toothpaste using Chinese medicine as active component are as the most important thing of Developing, but effect of the toothpaste taking Chinese medicine as active component not obvious more nowadays.
Given this, add the toothpaste of the Herba Dendrobii fruit extract with hemostasia effect, there is no this application in the market, its haemostatic effect is remarkable.
Summary of the invention
The object of the invention is to: for the problem of above-mentioned existence, provide one to there is anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, add the toothpaste of three taste Chinese herbal medicine, have advantages of natural safe, the toothpaste of the hemostasia effect on the relative market of its haemostatic effect is more remarkable, add Folium Isatidis and Radix Scutellariae to there is anti-inflammatory effect, be applicable to popular demand.
The technical solution used in the present invention is as follows:
One has anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, contains 0.2%～4% active ingredient for anti-inflammation hemostasia, blank substrate mastic in every 100g finished product mastic; Described active ingredient is the three taste Chinese medicine extract powder that extract from Herba Dendrobii fruit, Folium Isatidis and the former medicine of Radix Scutellariae three taste, and the mass ratio of described three taste Chinese medicine extract powder is 2:1:1.
This toothpaste adds the three taste Chinese herbal medicine for the active ingredient of anti-inflammation hemostasia: draw Herba Dendrobii fruit by research and experiment, have dissipating blood stasis hemostasis, reducing swelling and alleviating pain effect, not only can be used for trauma hemostasis and also can be used for oral cavity hemostasis, effect is remarkable; Folium Isatidis, has that heat clearing away is antipyretic, effect of anti-inflammatory, antibacterial, is applied to oral cavity, can be well antibacterial and alleviate sensitivity of tooth and better take care of one's teeth; Radix Scutellariae, has obvious antiinflammation.Above-mentioned prescription, scientific and reasonable compatibility, taking Herba Dendrobii as principal agent, taking Folium Isatidis and Radix Scutellariae as auxiliary, Chinese medicine composition synergism is remarkable, has significant anti-inflammation hemostasia effect.
Further, the constitutive material of described blank substrate mastic and percentage by weight thereof: comprise that silica 1 0～30%, calcium pyrophosphate 10～20%, sorbitol 35～40%, CMC0.5～1.0%, sodium lauroyl sarcosine 1～3%, essence 0.05～0.1%, saccharin sodium 0.3～0.5%, vitamin E 0.1～0.3%, surplus are pure water.
In general, blank substrate toothpaste is by abrasivus, wetting agent, surfactant, and binding agent, spice, sweeting agent form, and except the present invention need add herbal medicine efficacy composition, other raw material is also essential.The abrasivus that the present invention selects is silicon dioxide and calcium pyrophosphate, and the combination of this abrasivus can not only cleaning teeth, the most important thing is can not damage and periodontal tissue; Wetting agent is selected sorbitol, glycerol or propylene glycol, can regulate the pH value in oral cavity, plays the effect of buffering; Binding agent is selected CMC, is sanlose, can also select xanthan gum, can make the batching in toothpaste be uniformly dispersed, and improves its stability; Surfactant is selected sodium lauroyl sarcosine, and it is nontoxic, non-stimulated, does not affect toothpaste fragrance, have reduce the surface tension of liquid and make toothpaste rapidly diffusion to reach the effect in cleaning teeth and oral cavity; Adding sweeting agent and spice is in order to keep the pure and fresh of oral cavity long period, and improves the mouthfeel of toothpaste, alleviates the taste of Chinese medicine bitterness.
The production technology with anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, comprises the following steps:
1) Herba Dendrobii fruit, Folium Isatidis and Radix Scutellariae three taste Chinese herbal medicine are broken into respectively to powder and cross 20～30 orders, add respectively the each hot reflux of 10 times of amount ethanol to extract 3 times, each 2h that extracts, merge each extracts of Chinese herbal medicine, concentrate drying obtains corresponding extract xeraphium, mixes according to the above ratio three taste Chinese herbal medicine extract xeraphiums for subsequent use;
2) according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and step 1) in Chinese medicine extract, vacuum high-speed stirred is even, mastic is filled into multiple tube.
In sum, the invention has the beneficial effects as follows: show according to the test of pesticide effectiveness, toothpaste provided by the invention, for oral problem, particularly has anti-inflammation hemostasia, and has no side effect, and this medicinal herb components can play good preventive effect to gingival hemorrhage, periodontal disease.The preparation method of the extract of Chinese herbal medicine wherein in toothpaste provided by the invention, adopts alcohol reflux liquid, merge extractive liquid,, and then dryly obtains extract xeraphium, and the method has retained the active constituents of medicine in Chinese crude drug to greatest extent.Adopt the extract of Herba Dendrobii fruit, apply effect of its hemostasis, have advantages of that other Chinese herbal medicine do not have, compare Western medicine and have more natural safe advantage, the toothpaste of the hemostasia effect on the relative market of its haemostatic effect is more remarkable, add Folium Isatidis and Radix Scutellariae to there is anti-inflammatory effect, be applicable to popular demand.
Detailed description of the invention
The invention provides one and there is anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, in every 100g finished product mastic, contain 0.2%～4% active ingredient for anti-inflammation hemostasia, blank substrate mastic; Described active ingredient is the three taste Chinese medicine extract powder that extract from Herba Dendrobii fruit, Folium Isatidis and the former medicine of Radix Scutellariae three taste, and the mass ratio of described three taste Chinese medicine extract powder is 2:1:1.
In embodiment more provided by the invention, the constitutive material of described blank substrate mastic and percentage by weight thereof: comprise that silica 1 0～30%, calcium pyrophosphate 10～20%, sorbitol 35～40%, CMC0.5～1.0%, sodium lauroyl sarcosine 1～3%, essence 0.05～0.1%, saccharin sodium 0.3～0.5%, vitamin E 0.1～0.3%, surplus are pure water.
The present invention also provides a kind of production technology with anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, comprises the following steps:
1) Herba Dendrobii fruit, Folium Isatidis and Radix Scutellariae three taste Chinese herbal medicine are broken into respectively to powder and cross 20～30 orders, add respectively the each hot reflux of 10 times of amount ethanol to extract 3 times, each 2h that extracts, merge each extracts of Chinese herbal medicine, concentrate drying obtains corresponding extract xeraphium, mixes according to the above ratio three taste Chinese herbal medicine extract xeraphiums for subsequent use;
2) according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and step 1) in Chinese medicine extract, vacuum high-speed stirred is even, mastic is filled into multiple tube.
A kind of Herba Dendrobii fruit toothpaste with anti-inflammation hemostasia provided by the invention, show according to the test of pesticide effectiveness, it particularly has anti-inflammation hemostasia for oral problem, and have no side effect, this medicinal herb components can play good preventive effect to gingival hemorrhage, periodontal disease.Adopt the extract of Herba Dendrobii fruit, apply effect of its hemostasis, have advantages of that other Chinese herbal medicine do not have, compare Western medicine and have more natural safe advantage, the toothpaste of the hemostasia effect on the relative market of its haemostatic effect is more remarkable, add Folium Isatidis and Radix Scutellariae to there is anti-inflammatory effect, be applicable to popular demand.
Now technical solution of the present invention is further described in conjunction with the embodiments:
The preparation of embodiment 1 Chinese herbal medicine extract
Take raw material in following ratio: Herba Dendrobii fruit 100g, Folium Isatidis 65g, Radix Scutellariae 70g;
The preparation of extract: three taste Chinese herbal medicine are broken into respectively powder and cross 20～30 orders, adds respectively the each hot reflux of 10 times of amount ethanol to extract 3 times, extracts 2h at every turn, merges each extracts of Chinese herbal medicine, and concentrate drying obtains corresponding extract xeraphium;
The preparation of embodiment 2 toothpaste
Get three taste Chinese herbal medicine extract xeraphium routine 2:1:1 in mass ratio according to embodiment 1, be Herba Dendrobii fruit extract xeraphium 2g, Folium Isatidis extract xeraphium 1g, Radix Scutellariae extract xeraphium 1g in every 100g toothpaste, blank substrate mastic parts by weight of raw materials: silicon dioxide 25g, calcium pyrophosphate 15g, sorbitol 40g, CMC1g, sodium lauroyl sarcosine 2g, essence 0.1g, saccharin sodium 0.3g, vitamin E 0.3g, surplus are pure water.
Toothpaste preparation method: according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and Chinese medicine extract xeraphium, and vacuum high-speed stirred is even, and mastic is filled into multiple tube.
The preparation of embodiment 3 toothpaste
Get three taste Chinese herbal medicine extract xeraphium routine 2:1:1 in mass ratio according to embodiment 1, be Herba Dendrobii fruit extract xeraphium 1.5g, Folium Isatidis extract xeraphium 0.75g, Radix Scutellariae extract xeraphium 0.75g in every 100g toothpaste, blank substrate mastic parts by weight of raw materials: silicon dioxide 30g, calcium pyrophosphate 10g, sorbitol 35g, CMC1g, sodium lauroyl sarcosine 3g, essence 0.1g, saccharin sodium 0.3g, vitamin E 0.3g, surplus are pure water.
Toothpaste preparation method: according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and Chinese medicine extract xeraphium, and vacuum high-speed stirred is even, and mastic is filled into multiple tube.
The preparation of embodiment 4 toothpaste
Get three taste Chinese herbal medicine extract xeraphium routine 2:1:1 in mass ratio according to embodiment 1, be Herba Dendrobii fruit extract xeraphium 1.8g, Folium Isatidis extract xeraphium 0.9g, Radix Scutellariae extract xeraphium 0.9g in every 100g toothpaste, blank substrate mastic parts by weight of raw materials: silicon dioxide 30g, calcium pyrophosphate 15g, sorbitol 30g, CMC1g, sodium lauroyl sarcosine 1g, essence 0.1g, saccharin sodium 0.2g, vitamin E 0.2g, surplus are pure water.
Toothpaste preparation method: according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and Chinese medicine extract xeraphium, and vacuum high-speed stirred is even, and mastic is filled into multiple tube.
The preparation of embodiment 4 toothpaste
Get three taste Chinese herbal medicine extract xeraphium routine 2:1:1 in mass ratio according to embodiment 1, be Herba Dendrobii fruit extract xeraphium 1.8g, Folium Isatidis extract xeraphium 0.9g, Radix Scutellariae extract xeraphium 0.9g in every 100g toothpaste, blank substrate mastic parts by weight of raw materials: silicon dioxide 30g, calcium pyrophosphate 15g, sorbitol 30g, CMC1g, sodium lauroyl sarcosine 1g, essence 0.1g, saccharin sodium 0.2g, vitamin E 0.2g, surplus are pure water.
Toothpaste preparation method: according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and Chinese medicine extract xeraphium, and vacuum high-speed stirred is even, and mastic is filled into multiple tube.
The preparation of embodiment 5 toothpaste
Get three taste Chinese herbal medicine extract xeraphium routine 2:1:1 in mass ratio according to embodiment 1, be Herba Dendrobii fruit extract xeraphium 1g, Folium Isatidis extract xeraphium 0.5g, Radix Scutellariae extract xeraphium 0.5g in every 100g toothpaste, blank substrate mastic parts by weight of raw materials: silicon dioxide 30g, calcium pyrophosphate 20g, sorbitol 40g, CMC0.5g, sodium lauroyl sarcosine 2g, essence 0.05g, saccharin sodium 0.2g, vitamin E 0.2g, surplus are pure water.
Toothpaste preparation method: according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and Chinese medicine extract xeraphium, and vacuum high-speed stirred is even, and mastic is filled into multiple tube.
Choose totally 30 of healthy male white mouse 25g, be divided into 3 groups, the toothpaste obtaining produced according to the present invention carries out anastalsis test, mechanical damage is caused to mouse liver is hemorrhage to be tested, blank substrate toothpaste (containing Herba Dendrobii fruit extract) as blank group, YUNNAN BAIYAO toothpaste group (containing 0.2% YUNNAN BAIYAO) as a control group, the toothpaste for preparing of the present invention is as drug study group (Herba Dendrobii fruit toothpaste), the toothpaste preparing with embodiment 2 is as drug study group.By statistics, three groups of statistics are obtained to experimental data as table 1:
The haemostatic effect of table 1 to white mice local hemorrhage (x ± s)
| Group | Number of animals (only) | Hemostasis (s) |
| Blank group | 10 | >180 |
| YUNNAN BAIYAO toothpaste group | 10 | 61.2±7.88* |
| Herba Dendrobii fruit toothpaste group | 10 | 63.12±8.32*△ |
* in table: P<0.05 compared with blank substrate toothpaste, △: P>0.05 compared with YUNNAN BAIYAO toothpaste.
Experiment shows, the difference between blank group and positive controls, drug study group has significant (P<0.05), and between positive controls and drug study group, difference does not have significant (P>0.05).
Therefore, the relatively blank substrate toothpaste of Herba Dendrobii fruit toothpaste, YUNNAN BAIYAO toothpaste that embodiment 2 prepares, all the white mice of mechanical damage is had to significant anastalsis, show that the Herba Dendrobii fruit toothpaste that the present embodiment 2 prepares has significant anastalsis.And it is real
Execute example 3 to embodiment 5 and all there is same haemostatic effect with embodiment 2.
The test of the antiinflammation of Herba Dendrobii fruit toothpaste: adopt xylol to cause the experiment of Mice Auricle acute inflammation swelling antiinflammation, select 30 mices that weight is suitable, be divided at random three groups, 10 every group.Blank substrate toothpaste group (without the interpolation of any medicine), YUNNAN BAIYAO toothpaste group (effective ingredient contains 0.2%), Herba Dendrobii fruit toothpaste group (effective ingredient is the content 0.2% that the present embodiment 2 is minimum), obtain experimental data as table 2 by statistics:
The impact of the each toothpaste of table 2 on the swelling of Mice Auricle acute inflammation
| Group | Number of animals (only) | Dosage (g) | Auricle edema value (mg) |
| Blank substrate toothpaste group | 10 | 0.2 | 16.75±4.48 |
| YUNNAN BAIYAO toothpaste group | 10 | 0.2 | 10.28±3.67* |
| Herba Dendrobii fruit toothpaste group | 10 | 0.2 | 11.39±3.85*△ |
As shown in Table 2: with blank substrate toothpaste group contrast, * P<0.05; YUNNAN BAIYAO toothpaste group and the contrast of Herba Dendrobii fruit toothpaste, △ P>0.05.
Experimental data shows, contrasts with blank substrate toothpaste group, and YUNNAN BAIYAO toothpaste and Herba Dendrobii fruit toothpaste have significant antiinflammation; And YUNNAN BAIYAO toothpaste is compared with Herba Dendrobii fruit toothpaste, both antiinflammations are suitable, therefore show that the present embodiment 2 Herba Dendrobii fruit toothpaste have significant antiinflammation, and embodiment 3 to embodiment 5 all has same effect.
In the Herba Dendrobii fruit toothpaste with anti-inflammation hemostasia of the present invention, the compositions of active ingredient, can add the ancillary drug raw material as antiinflammatory, anastalsis in the oral cavity nursing health products such as collutory, chewing gum, dentifrice, throat lozenge equally.
Claims (3)
1. there is an anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, it is characterized in that: in every 100g finished product mastic, contain 0.2%～4% active ingredient for anti-inflammation hemostasia, blank substrate mastic; Described active ingredient is the three taste Chinese medicine extract powder that extract from Herba Dendrobii fruit, Folium Isatidis and the former medicine of Radix Scutellariae three taste, and the mass ratio of described three taste Chinese medicine extract powder is 2:1:1.
2. one as claimed in claim 1 has anti-inflammation hemostasia Herba Dendrobii fruit toothpaste, it is characterized in that constitutive material and the percentage by weight thereof of described blank substrate mastic: comprise that silica 1 0～30%, calcium pyrophosphate 10～20%, sorbitol 35～40%, CMC0.5～1.0%, sodium lauroyl sarcosine 1～3%, essence 0.05～0.1%, saccharin sodium 0.3～0.5%, vitamin E 0.1～0.3%, surplus are pure water.
3. a kind of production technology with anti-inflammation hemostasia Herba Dendrobii fruit toothpaste described in the claims, is characterized in that comprising the following steps:
1) Herba Dendrobii fruit, Folium Isatidis and Radix Scutellariae three taste Chinese herbal medicine are broken into respectively to powder and cross 20～30 orders, add respectively the each hot reflux of 10 times of amount ethanol to extract 3 times, each 2h that extracts, merge each extracts of Chinese herbal medicine, concentrate drying obtains corresponding extract xeraphium, mixes according to the above ratio three taste Chinese herbal medicine extract xeraphiums for subsequent use;
2) according to the above ratio saccharin sodium is dissolved in to pure water, sorbitol, CMC are added to Manufacturing medicine extract machine, stir and add aqueous solution without granule, add again silicon dioxide, calcium pyrophosphate and sodium lauroyl sarcosine, high-speed stirred under vacuum, and then add essence, vitamin E and step 1) in Chinese medicine extract, vacuum high-speed stirred is even, mastic is filled into multiple tube.
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| CN201410147624.6A CN103977264A (en) | 2014-04-14 | 2014-04-14 | Anti-inflammatory hemostatic dendrobium officinale fruit toothpaste |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224627A (en) * | 2014-09-18 | 2014-12-24 | 安徽科技学院 | Heat-clearing, detoxifying and health-care toothpaste and production method thereof |
| CN106692693A (en) * | 2016-12-01 | 2017-05-24 | 李妍 | Dendrobium officinale oral care agent and preparation method thereof |
| CN109620774A (en) * | 2019-01-28 | 2019-04-16 | 荆楚理工学院 | A kind of herbal mixture care toothpaste and preparation method thereof |
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| CN1078882A (en) * | 1992-05-20 | 1993-12-01 | 吴海元 | Multipurpose anti-caries liquid tooth-paste and compound method thereof |
| CN102973453A (en) * | 2011-09-07 | 2013-03-20 | 沈新荣 | Medicated toothpaste and preparation method thereof |
| CN103230356A (en) * | 2013-05-07 | 2013-08-07 | 贵州省赤水市金钗石斛产业开发有限公司 | Dendrobium nobile toothpaste |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078882A (en) * | 1992-05-20 | 1993-12-01 | 吴海元 | Multipurpose anti-caries liquid tooth-paste and compound method thereof |
| CN102973453A (en) * | 2011-09-07 | 2013-03-20 | 沈新荣 | Medicated toothpaste and preparation method thereof |
| CN103230356A (en) * | 2013-05-07 | 2013-08-07 | 贵州省赤水市金钗石斛产业开发有限公司 | Dendrobium nobile toothpaste |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224627A (en) * | 2014-09-18 | 2014-12-24 | 安徽科技学院 | Heat-clearing, detoxifying and health-care toothpaste and production method thereof |
| CN104224627B (en) * | 2014-09-18 | 2017-01-11 | 安徽科技学院 | Heat-clearing, detoxifying and health-care toothpaste and production method thereof |
| CN106692693A (en) * | 2016-12-01 | 2017-05-24 | 李妍 | Dendrobium officinale oral care agent and preparation method thereof |
| CN109620774A (en) * | 2019-01-28 | 2019-04-16 | 荆楚理工学院 | A kind of herbal mixture care toothpaste and preparation method thereof |
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