CN103520010A - Application of tetrahydropalmatine and naringin in preparing oral care products - Google Patents
Application of tetrahydropalmatine and naringin in preparing oral care products Download PDFInfo
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- CN103520010A CN103520010A CN201310487483.8A CN201310487483A CN103520010A CN 103520010 A CN103520010 A CN 103520010A CN 201310487483 A CN201310487483 A CN 201310487483A CN 103520010 A CN103520010 A CN 103520010A
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Abstract
The invention discloses application of tetrahydropalmatine and naringin in preparing oral care products, i.e., tetrahydropalmatine and naringin are added into an oral care health-care product as active ingredients with analgesic effect in form of a compound in a process of preparing oral care products. Compared with the prior art, the oral care products provided by the invention not only are safe to use, but also have remarkable analgesic effects.
Description
Technical field
The present invention relates to oral care implement technical field, especially a kind of tetrahydropalmatine and the application of naringin in preparing oral care product.
Background technology
Oral care implement is the important composition composition of personal-care supplies, closely bound up with people's lives.At present, the conventional oral care product of people is mainly toothpaste, and its basic function is exactly cleaning teeth, and fresh breath is safeguarded the hygiene and health in oral cavity.Along with the raising of people's living standard, the health care consciousness of consumer constantly strengthens, and oral care product has also been proposed to more requirement, and people have also increased some except having this basic function that cleans the teeth to the requirement of toothpaste can assist the effect of prevention oral disease.Therefore, toothpaste in the market and collutory almost all add the functional component for the various oral diseases of control, and the product that therefore oral care product both domestic and external has various functional types has become the market mainstream, is wherein to add western medicine composition to realize mostly.
But along with economic development, be accompanied by day by day manifesting of the problems such as environmental pollution, ecological disturbance, consumer more and more pays close attention to the safety of product, thereby more and more advocates natural and safe product.Interpolation can effectively prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, features such as green, environmental protection, safety height and be doubly subject to people's favor, and on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, the method for Chinese medicine study of active components utilization has also been obtained to fine development, this assists prevention oral disease that good technical support is provided for oral care product utilizes active ingredient of Chinese herbs.
Toothache is the oral disease being caused by many reasons, according to interrelated data, show, China has the consumer surpassing more than 50% to have toothache in various degree at different times, yet current domestic toothpaste market does not still have a this oral disease of special control and has the oral care implement of obvious effect, for this reason, be necessary to comply with the needs of market development, the Chinese herbal medicine extract safely and effectively of usining is developed a kind of oral care product of special control toothache as active component.
Summary of the invention
The problem that the present invention solves is to provide tetrahydropalmatine and the application scheme of naringin in preparing oral care product, and this oral cavity nursing health products has obvious analgesic activity.
Tetrahydropalmatine of the present invention and the naringin application scheme in preparing oral care product is exactly tetrahydropalmatine and naringin to be usingd to compound recipe form in preparing the technique of oral care product to join in oral care product as the active component of analgesic activity.
In technique scheme, scheme can also be more specifically: described tetrahydropalmatine and naringin in preparing toothpaste technique as the raw material of analgesic activity.
Further: the weight percent content in the total mastic of toothpaste is 0.1～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
Further: described tetrahydropalmatine and naringin in preparing collutory technique as the raw material of analgesic activity.
Further: the weight percent content in collutory total raw material is 0.1～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
Further: described tetrahydropalmatine and naringin in preparing dentifrice technique as the raw material of analgesic activity.
Further: the weight percent content in dentifrice total raw material is 0.1～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
Further: described tetrahydropalmatine and naringin in preparing throat lozenge technique as the raw material of analgesic activity.
Further: the weight percent content in throat lozenge total raw material is 0.1～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
Further: described tetrahydropalmatine and naringin in preparing chewing gum technique as the raw material of analgesic activity.
Further: the weight percent content in chewing gum total raw material is 0.1～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
The said Rhizoma Corydalis of the present invention is the dry tuber of papaveraceae plant corydalis (Corydalis yanhusuo W. T. Wang).Nature and flavor are pungent, bitter, temperature.GUIXIN, liver, spleen channel.Mainly there is promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain effect.Cure mainly epigastric pain, obstruction of qi in the chest and cardialgia, pain in the lumbar region, colicky, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling etc.Its tuber is planted containing alkaloid more than 10, wherein through what identify, there are dextrorotation corydaline (Corydaline), Tetrahydropalmatine (tetrahydropalmatine), protopine (Rhizoma Corydalis the third element), l-Tetrahydrocoptisine (Rhizoma Corydalis fourth element), racemization Tetrahydrocoptisine, left-handed tetrahydrocolumbamine, dextrorotation corybulbine, coptisine, a 13-Methylpalmatine, also have corydalmine, dehydrogenation corydalmine.The contained alkaloid of Rhizoma Corydalis has analgesic activity, and wherein second is plain, ugly element is stronger, and first element takes second place.Second element also has the effects such as hypnosis, calmness, stable, antiulcer, health arrhythmia.
The said naringin of the present invention is a kind of a kind of flavanone compounds being extensively present in Rutaceae Citrus (Citrusreticulata Blanco) class fruit.Pure naringin is a kind of white powder solid, has anti-inflammatory and antalgic, antiviral, antibacterial and suppress the effect of eye aldose reductase.The high sugariness of naringin, low heat value, the feature such as nontoxic, safe, can be widely used in food, medicine and daily chemical industry.
In the present invention, be with Rhizoma Corydalis and the various medical materials that contain naringin, as Fructus Aurantii, Fructus Aurantii Immaturus, mandarin orange, Fructus Citri Limoniae, grapefruit, the form of two taste compound Chinese medicine extracts is used, the extracting method of tetrahydropalmatine of the present invention and naringin be by the former medicine of the extract of tetrahydropalmatine and naringin in the ratio of 1:6 respectively scale go out, again every taste Chinese medicine is broken into certain granularity, with the alcohol heating reflux of 10 times of amounts, extract 3 hours, extract 3 times, then extracting solution concentrating under reduced pressure is become to extractum or is dried to powdery; The extracting method of herbal mixture is not limited to said method, also can adopt the additive methods such as supercritical extraction, ultrasonic extraction to extract.
It is example that the content of the herbal mixture described in the present invention all be take the pure extract powder that active component is 100%, but be not limited to pure extract powder, also can be other forms such as extracting solution or extractum, when being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of disclosed pure form of extract in the present invention.
Oral care implement of the present invention adds tetrahydropalmatine and naringin to have significant analgesic effect as natural plant active component in preparation process.
The present invention, to the oral cavity composition containing herbal mixture, more specifically, carries out the analgesic activity (hot plate method) to white mice to the toothpaste containing compound extract, makes positive control and blank simultaneously and observes.Experimental result shows, this herbal mixture toothpaste and positive control medicine diclofenac diethylammonium group, with the comparison of blank group, all can significantly improve the pain threshold of white mice, there is obvious analgesic activity, there were significant differences statistically, shows that this herbal mixture toothpaste has significant analgesic activity.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, related percentage ratio except as otherwise noted, is all to calculate by weight percentage.
Embodiment 1-5: tetrahydropalmatine and naringin be the application in toothpaste as compound Chinese medicine extract, tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
The toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:
The preparation method of toothpaste in embodiment 2:
Lotion of toothpaste can adopt the one-step method of conventional medicine toothpaste cream production technology processed to make: the liquid materials such as the pure water that input measures in temporary cylinder, sorbitol, compound Chinese medicine extract; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, sodium carboxymethyl cellulose, sodium lauryl sulphate, the nipalgin that measure and mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close successively colloid mill, agitator, scraper after 10 minutes, vacuum breaker, stops vacuum pump, after sampling detection is qualified, makes.
The production technology of the toothpaste of other embodiment is with reference to embodiment 1.
Embodiment 6-10: tetrahydropalmatine and naringin be the application in collutory as compound Chinese medicine extract, tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
The collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The preparation method of the collutory in embodiment 8:
First compound Chinese medicine extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol to be placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirred 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stirred 10 minutes, finally add essence to stir 5 minutes, stop stirring, after sampling detection is qualified, make.
The production technology of the collutory of other embodiment is with reference to embodiment 8.
Embodiment 11-15: tetrahydropalmatine and naringin be the application in dentifrice as compound Chinese medicine extract, tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
The dentifrice constitutive material of embodiment 11-15 and weight percent content are as following table:
The preparation method of dentifrice in embodiment 13:
After natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes and add compound Chinese medicine extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
The preparation method of dentifrice in embodiment 14:
After calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes; add compound Chinese medicine extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
The production technology of the dentifrice of other embodiment is with reference to embodiment 13 or embodiment 14.
Embodiment 16-20: tetrahydropalmatine and naringin be the application in throat lozenge as compound Chinese medicine extract, tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: tetrahydropalmatine and naringin be the application in chewing gum as compound Chinese medicine extract.
The chewing gum constitutive material of embodiment 21-25 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
clinical trial part:
The analgesic activity pharmacological experiment of compound Chinese medicine extract toothpaste:
Contain compound Chinese medicine extract toothpaste sample to the analgesic activity of white mice (hot plate method); Choose the healthy Kunming of body weight 18～22g kind ♀ white mice, with GJ-8402 type hot plate dolorimeter, regulate and control temperature at 55 ± 0.5 ℃, white mice is placed on to the pain threshold (white mice contact hot plate is to the time of licking metapedes) of measuring every Mus on hot plate, allly lick the metapedes time and be less than 5 seconds (S) or be greater than 30 seconds (S) and leaper gives it up, select 40 of qualified white mice, divide equally at random 4 groups, 10 every group.Blank group, the blank matrix group of toothpaste, positive drug diclofenac diethylamine emulgel group, herbal mixture toothpaste sample group.Each organizes the normal pain threshold that white mice repeats to measure for 2 times white mice by the same method, and every minor tick 15min, gets two subnormal pain threshold meansigma methodss, as the pain threshold before this group white mice administration.Respectively at 4 sufficient sole of the foots of the every Mus of each treated animal, be coated with and only give corresponding tested material 0.2g/, blank group is coated with only gives normal saline 0.2ml/, painting is given 15min, 30min after tested material, 45min and is measured respectively by the same method the pain threshold of white mice, as still reactionless in white mice 60 seconds (S), white mice is taken out, in order to avoid scald, its pain threshold calculates with 60 seconds (s), white mice pain threshold respectively organized in record, and data are carried out statistics t check, the results are shown in Table 1:
Experimental result shows, the front and blank group comparison with administration containing compound Chinese medicine extract toothpaste sample group and diclofenac diethylamine emulgel group, all can significantly improve white mice pain threshold; Containing compound Chinese medicine extract toothpaste sample group and the blank matrix group comparison of toothpaste, can significantly improve white mice pain threshold, show to there is obvious analgesic activity containing compound Chinese medicine extract toothpaste sample group.
conclusion:sample sets containing tetrahydropalmatine and naringin two taste compound Chinese medicine extract toothpaste can significantly improve white mice pain threshold, has obvious analgesic activity.
Claims (11)
1. tetrahydropalmatine and the naringin application in preparing oral care product, the compound recipe form of in preparing the technique of oral care product, tetrahydropalmatine and naringin being usingd adds in oral cavity nursing health products as the active component of analgesic activity.
2. tetrahydropalmatine according to claim 1 and the naringin application in preparing oral care product, is characterized in that: described tetrahydropalmatine and naringin in preparing toothpaste technique as the raw material of analgesic activity.
3. tetrahydropalmatine according to claim 2 and the naringin application in preparing oral care product, it is characterized in that: the weight percent content in the total mastic of toothpaste is 0.1%～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
4. tetrahydropalmatine according to claim 1 and the naringin application in preparing oral care product, is characterized in that: described tetrahydropalmatine and naringin in preparing collutory technique as the raw material of analgesic activity.
5. tetrahydropalmatine according to claim 4 and the naringin application in preparing oral care product, it is characterized in that: the weight percent content in collutory total raw material is 0.1%～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
6. tetrahydropalmatine according to claim 1 and the naringin application in preparing oral care product, is characterized in that: described tetrahydropalmatine and naringin in preparing dentifrice technique as the raw material of analgesic activity.
7. tetrahydropalmatine according to claim 6 and the naringin application in preparing oral care product, it is characterized in that: the weight percent content in dentifrice total raw material is 0.1%～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
8. tetrahydropalmatine according to claim 1 and the naringin application in preparing oral care product, is characterized in that: described tetrahydropalmatine and naringin in preparing throat lozenge technique as the raw material of analgesic activity.
9. tetrahydropalmatine according to claim 8 and the naringin application in preparing oral care product, it is characterized in that: the weight percent content in throat lozenge total raw material is 0.1%～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
10. tetrahydropalmatine according to claim 1 and the naringin application in preparing oral care product, is characterized in that: described tetrahydropalmatine and naringin in preparing chewing gum technique as the raw material of analgesic activity.
11. tetrahydropalmatines according to claim 10 and the application of naringin in preparing oral care product, it is characterized in that: the weight percent content in chewing gum total raw material is 0.1%～2.0% as compound Chinese medicine extract for described tetrahydropalmatine and naringin, described tetrahydropalmatine is 1:6 with the former medicine ratio of extract of naringin.
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Cited By (4)
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| CN104490946A (en) * | 2015-01-04 | 2015-04-08 | 两面针（江苏）实业有限公司 | Preparation process of uncinata spikemoss herb extract and application thereof in oral cleaning paste and liquid |
| CN104523506A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of securidaca inappendiculata extractive in preparation of oral care products for treating gingival ache |
| EP3517537A4 (en) * | 2016-10-13 | 2020-05-27 | Jingluweidai Information Consulting Service (Beijing) Co Ltd | Deuterated derivative of l-tetrahydropalmatine and medical use thereof |
| CN114469761A (en) * | 2021-12-28 | 2022-05-13 | 彭氏(惠州)实业发展有限公司 | Oral care compositions and methods of use and preparation thereof |
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| CN102218021A (en) * | 2010-04-15 | 2011-10-19 | 刘钦 | Toothpaste for removing halitosis and preventing canker sore |
| CN102961265A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of tetrahydropalmatine to preparation of oral care products |
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2013
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Patent Citations (3)
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| CN101244016A (en) * | 2008-03-17 | 2008-08-20 | 柳州两面针股份有限公司 | Application of aurantiin in preparing oral cavity nursing health products |
| CN102218021A (en) * | 2010-04-15 | 2011-10-19 | 刘钦 | Toothpaste for removing halitosis and preventing canker sore |
| CN102961265A (en) * | 2012-12-14 | 2013-03-13 | 柳州两面针股份有限公司 | Application of tetrahydropalmatine to preparation of oral care products |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104523506A (en) * | 2014-12-16 | 2015-04-22 | 广西科技大学 | Application of securidaca inappendiculata extractive in preparation of oral care products for treating gingival ache |
| CN104490946A (en) * | 2015-01-04 | 2015-04-08 | 两面针（江苏）实业有限公司 | Preparation process of uncinata spikemoss herb extract and application thereof in oral cleaning paste and liquid |
| CN104490946B (en) * | 2015-01-04 | 2017-11-03 | 两面针（江苏）实业有限公司 | A kind of preparation technology of Selaginella uncinata extraction and its application in oral cleaning cream, liquid |
| EP3517537A4 (en) * | 2016-10-13 | 2020-05-27 | Jingluweidai Information Consulting Service (Beijing) Co Ltd | Deuterated derivative of l-tetrahydropalmatine and medical use thereof |
| CN114469761A (en) * | 2021-12-28 | 2022-05-13 | 彭氏(惠州)实业发展有限公司 | Oral care compositions and methods of use and preparation thereof |
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Application publication date: 20140122 |