CN106692693A - Dendrobium officinale oral care agent and preparation method thereof - Google Patents
Dendrobium officinale oral care agent and preparation method thereof Download PDFInfo
- Publication number
- CN106692693A CN106692693A CN201611087401.0A CN201611087401A CN106692693A CN 106692693 A CN106692693 A CN 106692693A CN 201611087401 A CN201611087401 A CN 201611087401A CN 106692693 A CN106692693 A CN 106692693A
- Authority
- CN
- China
- Prior art keywords
- parts
- herb
- weight
- flower
- oral care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000002360 preparation method Methods 0.000 title claims description 9
- 239000008375 oral care agent Substances 0.000 title abstract 6
- 241001076416 Dendrobium tosaense Species 0.000 title abstract 5
- 241000594394 Hedyotis Species 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000006793 Artemisia stelleriana Nutrition 0.000 claims abstract description 17
- 244000252230 Artemisia stelleriana Species 0.000 claims abstract description 17
- 244000242564 Osmanthus fragrans Species 0.000 claims abstract description 16
- 235000019083 Osmanthus fragrans Nutrition 0.000 claims abstract description 16
- 244000178231 Rosmarinus officinalis Species 0.000 claims abstract description 15
- 239000001736 Calcium glycerylphosphate Substances 0.000 claims abstract description 12
- 241000133134 Saussurea Species 0.000 claims abstract description 12
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 claims abstract description 12
- 229940095618 calcium glycerophosphate Drugs 0.000 claims abstract description 12
- 235000019299 calcium glycerylphosphate Nutrition 0.000 claims abstract description 12
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 11
- 210000000214 mouth Anatomy 0.000 claims description 30
- 239000003795 chemical substances by application Substances 0.000 claims description 28
- 241000026010 Dendrobium candidum Species 0.000 claims description 27
- 230000000474 nursing effect Effects 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 235000019441 ethanol Nutrition 0.000 claims description 20
- 241000336315 Cistanche salsa Species 0.000 claims description 16
- 241000237536 Mytilus edulis Species 0.000 claims description 16
- 244000223014 Syzygium aromaticum Species 0.000 claims description 16
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 16
- 239000013505 freshwater Substances 0.000 claims description 16
- 235000020638 mussel Nutrition 0.000 claims description 16
- 235000017396 Menta cendrata Nutrition 0.000 claims description 11
- 235000010672 Monarda didyma Nutrition 0.000 claims description 11
- 241001062991 Pycnanthemum Species 0.000 claims description 11
- 239000012141 concentrate Substances 0.000 claims description 10
- 125000005909 ethyl alcohol group Chemical group 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000007654 immersion Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 5
- 238000001694 spray drying Methods 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 208000030194 mouth disease Diseases 0.000 abstract description 5
- 208000020670 canker sore Diseases 0.000 abstract description 4
- 241000231176 Boschniakia rossica Species 0.000 abstract 1
- 241000628997 Flos Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 244000245214 Mentha canadensis Species 0.000 abstract 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 abstract 1
- 208000025157 Oral disease Diseases 0.000 abstract 1
- 244000103849 Tradescantia spathacea Species 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 229940071085 lauroyl glutamate Drugs 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 31
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 208000010266 Aggressive Periodontitis Diseases 0.000 description 3
- 244000025254 Cannabis sativa Species 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 201000006727 periodontosis Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- AVBJHQDHVYGQLS-AWEZNQCLSA-N (2s)-2-(dodecanoylamino)pentanedioic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCC(O)=O AVBJHQDHVYGQLS-AWEZNQCLSA-N 0.000 description 1
- 208000004020 Brain Abscess Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 208000020717 oral cavity carcinoma Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a dendrobium officinale oral care agent. The dendrobium officinale oral care agent is prepared from the following components in parts by weight: 29 to 33 parts of dendrobii officinalis caulis, 10 to 14 parts of herb of boschniakia rossica, 11 to 13 parts of liquorice root, 8 to 10 parts of herb of artemisia stelleriana, 12 to 14 parts of scabrid smallhooked hedyotis herb, 9 to 12 parts of herb of saussurea involucrate, 6 to 8 parts of herb of mentha haplocalyx, 6 to 9 parts of herba lycopi, 10 to 15 parts of flower of osmanthus fragrans, 7 to 9 parts of caryophylli flos, 8 to 10 parts of herb of rosmarinus officinalis, 2 to 4 parts of floral leaf of rhoeo spathacea, 0.1 to 0.3 part of calcium glycerophosphate, 0.2 to 0.3 part of N-lauroyl glutamate and 190 to 200 parts of deionized water. The dendrobium officinale oral care agent has the advantages that oral diseases of different degrees, such as canker sore, periodontal disease and decayed tooth, can be effectively treated; the oral care agent takes effect quickly, and the pain of a patient is greatly relieved; the toxicity and injury to a human body are avoided, and the dendrobium officinale oral care agent can be taken for a long time.
Description
Technical field
The invention belongs to oral cavity nursing agent field, and in particular to a kind of dendrobium candidum oral cavity nursing agent and preparation method thereof.
Background technology
Mouth disease by the incidence of disease it is high, patient groups are wide, it is popular with the characteristics of, as a kind of disease the most multiple in the world
Disease.According to investigations, China 74% population it is different degrees of with mouth diseases such as canker sore, periodontosis, carious teeth.Oral cavity
What disease brought patient is not only that absence of tooth or initiation halitosis are so simple, and severe patient even can cause carcinoma of mouth, cerebral infarction
The disease such as plug, brain abscess, rheumatism or rheumatoid arthritis, skin disease, ephritis.
There are the products such as many commercially available oral health water, mouthwashes at present, but its effect is unsatisfactory, can only be temporary transient
Alleviate some oral problems, it is impossible to permanent effective for oral cavity provides a state for safety and stability.
The content of the invention
In order to solve the above problems, the present invention provides a kind of dendrobium candidum oral cavity nursing agent and preparation method thereof.
The present invention is achieved by the following technical solutions.
A kind of dendrobium candidum oral cavity nursing agent, is made up of the component of following weight portion：Dendrobium candidum 29-33 parts, broomrape
10-14 parts, Herba Hedyotis cantonensis 11-13 parts, Artemisia stelleriana 8-10 parts, scabrid smallhooked hedyotis herb 12-14 parts, lanatechead saussurea herb with flower 9-12 parts, mountain mint 6-8 parts, Herba Lycopi 6-9
Part, sweet osmanthus 10-15 parts, cloves 7-9 parts, rosemary 8-10 parts, freshwater mussel flower 2-4 parts, calcium glycerophosphate 0.1-0.3 parts, N- lauroyl
Glutamic acid 0.2-0.3 parts, deionized water 190-200 parts.
A kind of preparation method of dendrobium candidum oral cavity nursing agent, comprises the following steps：
（1）Take dry dendrobium candidum, after being put into clear water immersion 2-3 hour, then using big fire decoction 4-5 hours after, mistake
Filter, obtains filtrate standby；
（2）Broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb are put into 2 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 2 hours
Afterwards, extract solution is filtered, filtered solution reclaims ethanol, broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb mixed extract is obtained；
（3）It is that the temperature in 5 times is immersion 3 hours in 40-45 DEG C of warm water that lanatechead saussurea herb with flower, mountain mint, Herba Lycopi are put into its weight,
Then mashed into paste shape, after spray drying, is crushed, and crosses 240-260 mesh sieves, standby；
（4）Sweet osmanthus, cloves, rosemary, freshwater mussel flower are put into 1.8 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 1.5 is small
When, extract solution is filtered, filtered solution reclaims ethanol and is concentrated into relative density for 1.2g/cm3, the temperature of concentrate is 50 DEG C,
When concentrate is down to room temperature, sweet osmanthus, cloves, rosemary, freshwater mussel flower extract solution is obtained；
（5）By step（1）Gained filtrate, step（2）Gained extract solution, step（3）Gained powder, step（4）Gained extract solution
Add in deionized water, after stirring, add calcium glycerophosphate, continue to stir, be eventually adding N- lauroyl glutamates,
Oral cavity nursing agent is obtained.
Technical scheme more than, the beneficial effects of the invention are as follows：
The present invention provide a kind of dendrobium candidum oral cavity nursing agent, can effectively treat different degrees of canker sore, periodontosis,
The mouth diseases such as carious tooth, curative effect is fast, can greatly mitigate the pain of patient, and the oral cavity nursing agent that the present invention is provided, to people
Human body is nontoxic, can long-term taking.Wherein, the active ingredient association in dendrobium candidum and broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb
Same-action, can effectively treat canker sore symptom, and it can also effectively remove halitosis；Lanatechead saussurea herb with flower, mountain mint, Ze Lanzhong
Active ingredient synergy, pure and fresh implication can be maintained, can effectively remove enamel again, improve the whiteness of tooth；Osmanthus
Active ingredient synergy in flower, cloves, rosemary, freshwater mussel flower, can effectively treat periodontosis, and the work(with clearing heat and removing internal heat
Effect；Active ingredient synergy in calcium glycerophosphate and N- lauroyl glutamates, during dental caries, raising enamel can be stopped with antibacterial
Calcium, phosphorus content, the acid-base property that enamel surface can be changed, strengthen its capacity antacid, and it can also effectively extend mouth
The shelf-life of chamber care agent, prevent the generation for having precipitation in oral cavity nursing agent.
Specific embodiment
Following examples are used to illustrate the present invention, but can not be used for limiting the scope of the present invention.The reality used in embodiment
The condition of applying can be for further adjustments according to the condition of producer, and unaccounted implementation condition is usually conventional laboratory conditions.
Embodiment 1
A kind of dendrobium candidum oral cavity nursing agent, is made up of the component of following weight portion：It is 29 parts of dendrobium candidum, 10 parts of broomrape, sweet
11 parts of grass, 8 parts of Artemisia stelleriana, 12 parts of scabrid smallhooked hedyotis herb, 9 parts of lanatechead saussurea herb with flower, 6 parts of mountain mint, 6 parts of Herba Lycopi, 10 parts of sweet osmanthus, 7 parts of cloves, rosemary
8 parts, 2 parts of freshwater mussel flower, 0.1 part of calcium glycerophosphate, 0.2 part of N- lauroyl glutamates, 190 parts of deionized water.
A kind of preparation method of dendrobium candidum oral cavity nursing agent, comprises the following steps：
（1）Dry dendrobium candidum is taken, after being put into clear water immersion 2 hours, after then being decocted 4 hours using big fire, filtering is obtained
Filtrate is standby；
（2）Broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb are put into 2 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 2 hours
Afterwards, extract solution is filtered, filtered solution reclaims ethanol, broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb mixed extract is obtained；
（3）It is to soak 3 hours in the warm water that the temperature in 5 times is 40 DEG C that lanatechead saussurea herb with flower, mountain mint, Herba Lycopi are put into its weight, so
Mashed into paste shape, after spray drying, is crushed afterwards, crosses 240 mesh sieves, standby；
（4）Sweet osmanthus, cloves, rosemary, freshwater mussel flower are put into 1.8 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 1.5 is small
When, extract solution is filtered, filtered solution reclaims ethanol and is concentrated into relative density for 1.2g/cm3, the temperature of concentrate is 50 DEG C,
When concentrate is down to room temperature, sweet osmanthus, cloves, rosemary, freshwater mussel flower extract solution is obtained；
（5）By step（1）Gained filtrate, step（2）Gained extract solution, step（3）Gained powder, step（4）Gained extract solution
Add in deionized water, after stirring, add calcium glycerophosphate, continue to stir, be eventually adding N- lauroyl glutamates,
Oral cavity nursing agent is obtained.
Embodiment 2
A kind of dendrobium candidum oral cavity nursing agent, is made up of the component of following weight portion：It is 31 parts of dendrobium candidum, 12 parts of broomrape, sweet
12 parts of grass, 9 parts of Artemisia stelleriana, 13 parts of scabrid smallhooked hedyotis herb, 11 parts of lanatechead saussurea herb with flower, 7 parts of mountain mint, 8 parts of Herba Lycopi, 13 parts of sweet osmanthus, 8 parts of cloves, fan change
Fragrant 9 parts, 3 parts of freshwater mussel flower, 0.2 part of calcium glycerophosphate, 0.2 part of N- lauroyl glutamates, 195 parts of deionized water.
A kind of preparation method of dendrobium candidum oral cavity nursing agent, comprises the following steps：
（1）Dry dendrobium candidum is taken, after being put into clear water immersion 2 hours, after then being decocted 4.5 hours using big fire, filtering,
Obtain filtrate standby；
（2）Broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb are put into 2 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 2 hours
Afterwards, extract solution is filtered, filtered solution reclaims ethanol, broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb mixed extract is obtained；
（3）It is to soak 3 hours in the warm water that the temperature in 5 times is 43 DEG C that lanatechead saussurea herb with flower, mountain mint, Herba Lycopi are put into its weight, so
Mashed into paste shape, after spray drying, is crushed afterwards, crosses 250 mesh sieves, standby；
（4）Sweet osmanthus, cloves, rosemary, freshwater mussel flower are put into 1.8 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 1.5 is small
When, extract solution is filtered, filtered solution reclaims ethanol and is concentrated into relative density for 1.2g/cm3, the temperature of concentrate is 50 DEG C,
When concentrate is down to room temperature, sweet osmanthus, cloves, rosemary, freshwater mussel flower extract solution is obtained；
（5）By step（1）Gained filtrate, step（2）Gained extract solution, step（3）Gained powder, step（4）Gained extract solution
Add in deionized water, after stirring, add calcium glycerophosphate, continue to stir, be eventually adding N- lauroyl glutamates,
Oral cavity nursing agent is obtained.
Embodiment 3
A kind of dendrobium candidum oral cavity nursing agent, is made up of the component of following weight portion：It is 33 parts of dendrobium candidum, 14 parts of broomrape, sweet
13 parts of grass, 10 parts of Artemisia stelleriana, 14 parts of scabrid smallhooked hedyotis herb, 12 parts of lanatechead saussurea herb with flower, 8 parts of mountain mint, 9 parts of Herba Lycopi, 15 parts of sweet osmanthus, 9 parts of cloves, fan change
Fragrant 10 parts, 4 parts of freshwater mussel flower, 0.3 part of calcium glycerophosphate, 0.3 part of N- lauroyl glutamates, 200 parts of deionized water.
A kind of preparation method of dendrobium candidum oral cavity nursing agent, comprises the following steps：
（1）Dry dendrobium candidum is taken, after being put into clear water immersion 3 hours, after then being decocted 5 hours using big fire, filtering is obtained
Filtrate is standby；
（2）Broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb are put into 2 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 2 hours
Afterwards, extract solution is filtered, filtered solution reclaims ethanol, broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb mixed extract is obtained；
（3）It is to soak 3 hours in the warm water that the temperature in 5 times is 45 DEG C that lanatechead saussurea herb with flower, mountain mint, Herba Lycopi are put into its weight, so
Mashed into paste shape, after spray drying, is crushed afterwards, crosses 260 mesh sieves, standby；
（4）Sweet osmanthus, cloves, rosemary, freshwater mussel flower are put into 1.8 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 1.5 is small
When, extract solution is filtered, filtered solution reclaims ethanol and is concentrated into relative density for 1.2g/cm3, the temperature of concentrate is 50 DEG C,
When concentrate is down to room temperature, sweet osmanthus, cloves, rosemary, freshwater mussel flower extract solution is obtained；
（5）By step（1）Gained filtrate, step（2）Gained extract solution, step（3）Gained powder, step（4）Gained extract solution
Add in deionized water, after stirring, add calcium glycerophosphate, continue to stir, be eventually adding N- lauroyl glutamates,
Oral cavity nursing agent is obtained.
Experiment
The nursing efficacy of a kind of dendrobium candidum oral cavity nursing agent of embodiment and the commercially available common oral cavity nursing agent of comparative example：
Effectively：Malaise symptoms mitigate or disappear；It is invalid：Malaise symptoms are constant or more serious.、、
Long-term each 200 of the patient with mouth disease of random selection, is randomly divided into 2 groups, every group of 100 people, and everyone is in the tested phase
Between do not take other oral health-care products deliberately, drink this group of care agent 150ml for each person every day, the tested time is 30 days, embodiment 1
A kind of dendrobium candidum oral cavity nursing agent health-care effect is shown in Table 1：
As shown in Table 1, a kind of dendrobium candidum oral cavity nursing agent that the present invention is provided, can effectively solve the problem that various oral problems, energy
So that user keep fit for a long time, pure and fresh oral cavity.
It should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted.Although with reference to compared with
Good embodiment has been described in detail to the present invention, it will be understood by those within the art that, can be to the technology of invention
Scheme is modified or equivalent, and without deviating from the scope of technical solution of the present invention, it all should cover in power of the invention
In sharp claimed range.
Claims (2)
1. a kind of dendrobium candidum oral cavity nursing agent, it is characterised in that be made up of the component of following weight portion：Dendrobium candidum 29-33
Part, broomrape 10-14 parts, Herba Hedyotis cantonensis 11-13 parts, Artemisia stelleriana 8-10 parts, scabrid smallhooked hedyotis herb 12-14 parts, lanatechead saussurea herb with flower 9-12 parts, mountain mint 6-8
Part, Herba Lycopi 6-9 parts, sweet osmanthus 10-15 parts, cloves 7-9 parts, rosemary 8-10 parts, freshwater mussel flower 2-4 parts, calcium glycerophosphate 0.1-0.3
Part, 0.2-0.3 parts, deionized water 190-200 parts of N- lauroyl glutamates.
2. the preparation method of the oral cavity nursing agent described in a kind of claim 1, it is characterised in that comprise the following steps：
（1）Take dry dendrobium candidum, after being put into clear water immersion 2-3 hour, then using big fire decoction 4-5 hours after, mistake
Filter, obtains filtrate standby；
（2）Broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb are put into 2 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 2 hours
Afterwards, extract solution is filtered, filtered solution reclaims ethanol, broomrape, Herba Hedyotis cantonensis, Artemisia stelleriana, scabrid smallhooked hedyotis herb mixed extract is obtained；
（3）It is that the temperature in 5 times is immersion 3 hours in 40-45 DEG C of warm water that lanatechead saussurea herb with flower, mountain mint, Herba Lycopi are put into its weight,
Then mashed into paste shape, after spray drying, is crushed, and crosses 240-260 mesh sieves, standby；
（4）Sweet osmanthus, cloves, rosemary, freshwater mussel flower are put into 1.8 times of absolute ethyl alcohols of weight of its weight, heating and refluxing extraction 1.5 is small
When, extract solution is filtered, filtered solution reclaims ethanol and is concentrated into relative density for 1.2g/cm3, the temperature of concentrate is 50 DEG C,
When concentrate is down to room temperature, sweet osmanthus, cloves, rosemary, freshwater mussel flower extract solution is obtained；
（5）By step（1）Gained filtrate, step（2）Gained extract solution, step（3）Gained powder, step（4）Gained extract solution
Add in deionized water, after stirring, add calcium glycerophosphate, continue to stir, be eventually adding N- lauroyl glutamates,
Oral cavity nursing agent is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611087401.0A CN106692693A (en) | 2016-12-01 | 2016-12-01 | Dendrobium officinale oral care agent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611087401.0A CN106692693A (en) | 2016-12-01 | 2016-12-01 | Dendrobium officinale oral care agent and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692693A true CN106692693A (en) | 2017-05-24 |
Family
ID=58935405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611087401.0A Withdrawn CN106692693A (en) | 2016-12-01 | 2016-12-01 | Dendrobium officinale oral care agent and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106692693A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977264A (en) * | 2014-04-14 | 2014-08-13 | 广西健宝石斛有限责任公司 | Anti-inflammatory hemostatic dendrobium officinale fruit toothpaste |
-
2016
- 2016-12-01 CN CN201611087401.0A patent/CN106692693A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977264A (en) * | 2014-04-14 | 2014-08-13 | 广西健宝石斛有限责任公司 | Anti-inflammatory hemostatic dendrobium officinale fruit toothpaste |
Non-Patent Citations (1)
| Title |
|---|
| 徐春生: "防龋牙膏的配方设计", 《口腔护理用品工业》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6811769B2 (en) | Oral composition, method of making the oral composition and oral hygiene method in japanese and chinese herbal remedy | |
| CN104940050A (en) | Use of agilawood volatile oil stoste in preparation of skin-care product | |
| CN104173253A (en) | Children toothpaste for preventing decayed teeth | |
| CN107648166A (en) | Natural nano toothpaste | |
| CN102138887A (en) | Multifunctional compound golden thread Chinese medicinal herb toothpaste | |
| CN104688629A (en) | Mouthwash for preventing oral ulcer inflammation | |
| CN106580866A (en) | Toothpaste for children | |
| Charantimath et al. | Herbal therapy in dentistry: a review | |
| CN113616721A (en) | Pharmaceutical composition for treating oral ulcer and preparation method and application thereof | |
| CN104873446A (en) | Cinnamon oil containing toothpaste | |
| CN108567906B (en) | Lithospermum ointment and preparation method thereof | |
| CN107007688A (en) | Treat medicinal herb spray of oral inflammation and preparation method thereof | |
| CN103550454A (en) | Traditional Chinese medicine preparation for treating periodontitis | |
| CN108158899A (en) | A kind of mouthwash containing vine tea flavone extract and preparation method thereof | |
| CN106692693A (en) | Dendrobium officinale oral care agent and preparation method thereof | |
| Mahant et al. | Home remedies for dental diseases in the Pandemic of COVID-19-A Systematic Review | |
| CN106344451A (en) | Traditional Chinese medicine tooth-care toothpaste | |
| CN105106096A (en) | Oral care solution | |
| CN112022947A (en) | Bacteriostatic agent based on traditional Chinese herbal medicines and small molecular compounds, and preparation method and application thereof | |
| CN105456708B (en) | Medicine for treating cheilitis and preparation method thereof | |
| CN104606105A (en) | Plant nanoemulsion toothpaste | |
| CN110772598A (en) | Composition for treating aphtha, application and taking method thereof | |
| CN104524306A (en) | Mouthwash medicament for treating toothache and preparation method | |
| CN104958220A (en) | Traditional Chinese medicine toothpaste | |
| CN114404522B (en) | Chinese herbal medicine composition, gargle and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170524 |
|
| WW01 | Invention patent application withdrawn after publication |