CN104524306A - Mouthwash medicament for treating toothache and preparation method - Google Patents
Mouthwash medicament for treating toothache and preparation method Download PDFInfo
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- CN104524306A CN104524306A CN201510017340.XA CN201510017340A CN104524306A CN 104524306 A CN104524306 A CN 104524306A CN 201510017340 A CN201510017340 A CN 201510017340A CN 104524306 A CN104524306 A CN 104524306A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a mouthwash medicament for treating toothache. The mouthwash medicament for treating toothache is mainly prepared by the following raw materials including, by weight, 9-15 parts of dandelion, 6-12 parts of oroxylum indicum, 8-16 parts of scutellaria baicalensis, 6-12 parts of cynanchum paniculatum roots, 8-12 parts of asarum sieboldi (added later), 8-15 parts of divaricate saposhnikovia roots, 10-16 parts of Chinese gall, 12-15 parts of halite, 10-15 parts of indigowoad leaves, 8-12 parts of rhizoma anemarrhenae, 10-20 parts of honeysuckle and 8-15 parts of lalang grass rhizome. The mouthwash medicament is prepared by traditional Chinese medicine materials, is safe and free of toxic and side effects, is researched according to a traditional Chinese medicine principle and toothache pathology and pathogenesis and has the effects of clearing heat-fire, dredging orifices, relieving pain, soothing the liver, eliminating stagnation and the like. In addition, a clinical test proves that prepared mouthwash is effective, good in curative effect and capable of treating both manifestation and root cause of diseases.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of collutory medicament and preparation method for the treatment of toothache.
Background technology
Toothache refers to the pain that tooth causes because of a variety of causes, is one of symptom common in oral disease, is found in the dental caries of western medicine, pulpitis, apical periodontitis and dentin hypersensitiveness etc.Toothache outbreak or increase the weight of when meeting hot and cold, sour, sweet etc. stimulation, belongs to " gingival atrophy ", " osteomyelitis of the maxillary bone " category of the traditional Chinese medical science.That has a toothache shows as red swelling of gingiva, chance caloric stimulation pain, buccal swelling etc.Toothache is caused by gingivitis, periodontitis, decayed tooth or Fractured teeth caused by dental pulp (dental nerve) infection mostly.Toothache belongs to the external reaction of tooth defect, and be likely that the gingiva around dental caries, dental pulp or canine tooth is infected, premolar teeth occurs that slight crack also can cause toothache, is only sometimes that dish bits are stuck in teeth space and cause discomfort.The traditional Chinese medical science is thought: the evil poison of wind heat invasion and attack wind-fire is invaded, and injures tooth body and gingiva meat, evilly poly-ly not to fall apart, and QI and blood is detained, and air pocket is obstructed, stasis blocking venation and be disease.Further, hands, Foot yangming Channel arteries and veins are respectively lower tooth, upper tooth, attack meridians outside large intestine, stomach internal organs accumulated heat or ailment said due to cold or exposure, strongly fragrant in Yang Ming fire-transformation, pathogenic fire follow through upper inflammation send out toothache.Kidney governing bones, tooth being the surplus of the bone, deficiency of kidney yin, hyperactivity of deficient fire also can cause toothache.Also have the thing of the sweet acid of polyphagia, ability to speak is unclean, dirty dirty erosion tooth and the person of having a pain.Therefore, the traditional Chinese medical science thinks that toothache is caused by the reasons such as diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, excessiveness of stomach-fire, hyperactivity of fire of suffering from a deficiency of the kidney, worm-eaten tooth.The Therapeutic Method of having a toothache has many kinds, generally adopts Drug therapy.A lot of people commonly uses metronidazole, ibuprofen Western medicine etc. and relieves the pain.The Chinese patent literature of publication number CN103735750 A (application number 201410027572.9) discloses a kind of bag bubble collutory for the treatment of toothache, main Chinese medicinal materials has: Ampelopsis grossedentata 5-20%, Folium Polygoni Cuspidati 10-30%, Fructus Zanthoxyli 10-30%, Herba Asari 5-10%, Sal 5-30%.The Chinese patent literature of publication number CN 104069012 A (application number 201310105244.1) discloses tooth pain relieving Anti-caries mouthwash, is made up of sodium carbonate, sodium bicarbonate and water.The Chinese patent literature of publication number CN 104107277 A (application number 201410313459.7) discloses a kind of collutory alleviating toothache and preparation method thereof, and it is made up of tcm components concentrated solution I20-30%, the concentrated liquid of tradition Chinese medicine II 10-20%, MAJIAO liquid 3-10%, ibuprofen 2-8%, aspirin 2-8%, metronidazole 5-10%, chlorphenamine 2-5%, Borneolum Syntheticum 1-5% and water 20-40%; Described the concentrated liquid of tradition Chinese medicine I is extracted by following raw material, concentrated make: Zaocys, Rhizoma Typhonii, Rhizoma alpiniae chinensis, Radix Angelicae Pubescentis, Herba Taraxaci, Radix Actinidiae Chinensis, Myrrha, Calculus Bovis, Radix Sophorae Tonkinensis, Radix Sophorae Flavescentis, Scorpio, Fructus Viticis, Rhizoma Panacis Majoris and moisture content; Described the concentrated liquid of tradition Chinese medicine II is extracted by following raw material, concentrated make: careless Radix Clematidis, Flos Carthami part, catechu, Radix Notoginseng and water; Described MAJIAO liquid by MAJIAO raw material extracting in water, concentrated to make.
Western medicine toothache is cured the symptoms, not the disease, and long-term taking has side effect, large to human injury, treatment by Chinese herbs side effect is little, can not develop immunity to drugs, the case utilizing active ingredient of Chinese herbs to be developed into collutory in recent years gets more and more, but still little for the collutory kind alleviating toothache, therefore necessaryly works out a kind of collutory effectively alleviating toothache fast.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of determined curative effect, use safety treatment toothache collutory medicament and preparation method.
Technical scheme of the present invention is:
Treat a collutory medicament for toothache, be prepared from primarily of following bulk drugs, be weight portion: Herba Taraxaci 9-15, Semen Oroxyli 6-12, Radix Scutellariae 8-16, Radix Cynanchi Paniculati 6-12, Herba Asari (entering afterwards) 8-12, Radix Saposhnikoviae 8-15, Galla Chinensis 10-16, halite 12-15, Folium Isatidis 10-15, Rhizoma Anemarrhenae 8-12, Flos Lonicerae 10-20, Rhizoma Imperatae 8-15.
In preferred scheme, Herba Taraxaci 10-14, Semen Oroxyli 8-10, Radix Scutellariae 10-14, Radix Cynanchi Paniculati 8-10, Herba Asari (entering afterwards) 9-11, Radix Saposhnikoviae 10-13, Galla Chinensis 12-14, halite 13-14, Folium Isatidis 11-14, Rhizoma Anemarrhenae 9-11, Flos Lonicerae 12-18, Rhizoma Imperatae 10-13.
Be more preferably, Herba Taraxaci 12, Semen Oroxyli 9, Radix Scutellariae 12, Radix Cynanchi Paniculati 9, Herba Asari (entering afterwards) 10, Radix Saposhnikoviae 11.5, Galla Chinensis 13, halite 13.5, Folium Isatidis 12.5, the Rhizoma Anemarrhenae 10, Flos Lonicerae 15, Rhizoma Imperatae 11.5.
Described a kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then it is vexed to add saline, rear taking-up, and section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with wine, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add water making beating, after having pulled an oar, poured into by serosity in non iron container, heated and boiled adds Herba Asari after continuing, continue to boil 15 minutes, cooling leaves standstill, and filters, and collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
Described a kind of preparation method for the treatment of the collutory medicament of toothache, the concentration of step (1) saline is that (preferred, the concentration of saline is 17-23% to 15-25%; Be more preferably, the concentration of saline is 20%).
Described a kind of preparation method for the treatment of the collutory medicament of toothache, the amount of step (2) wine is the 1-3 of Rhizoma Imperatae doubly (preferred, the amount of wine is 2 times of Rhizoma Imperatae).
Described a kind of preparation method for the treatment of the collutory medicament of toothache, step (3) amount of water is that doubly (preferred, amount of water is 12-14 times of quality of medicinal material to the 10-16 of quality of medicinal material; Be more preferably, amount of water is 13 times of quality of medicinal material).
Described a kind of preparation method for the treatment of the collutory medicament of toothache, step (3) heated and boiled continues 10-20 minute, and (heated and boiled continues 12-18 minute; Be more preferably, heated and boiled continues 15 minutes).
Described a kind of preparation method for the treatment of the collutory medicament of toothache, step (3) cooling leaves standstill 6-10 hour, and (preferred, cooling leaves standstill 7-9 hour; Be more preferably, cooling leaves standstill 8 hours).
Described a kind of preparation method for the treatment of the collutory medicament of toothache, is characterized in that, the order number that step (3) filters screen cloth used is that (preferred, the order number filtering screen cloth used is 120-180 order to 100-200 order; Be more preferably, the order number filtering screen cloth used is 150 orders).
Present invention also offers the described a kind of application of collutory medicament when preparing the medicine for the treatment of toothache for the treatment of toothache.
A kind of collutory medicament compatibility for the treatment of toothache provided by the invention is rigorous, and preparation is simple.In addition, excellent results of the present invention also shows:
1, the present invention uses Chinese medicine material, ensures safe without toxic side effect;
2, this prescription obtains according to Chinese medicine principle and toothache pathology etiological study, has the effects such as clearing away heat-fire, understand things pain-stopping, soothing the liver eliminating stagnation;
3, the made collutory of the present invention is verified through clinical trial, instant effect, and good effect can treating both the principal and secondary aspects of a disease.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 one kinds treats the collutory medicament of toothache, is prepared from primarily of following bulk drugs, every part of 5g: Herba Taraxaci 9 parts, Semen Oroxyli 6 parts, Radix Scutellariae 8 parts, Radix Cynanchi Paniculati 6 parts, Herba Asari (entering afterwards) 8 parts, Radix Saposhnikoviae 8 parts, Galla Chinensis 10 parts, halite 12 parts, Folium Isatidis 10 parts, the Rhizoma Anemarrhenae 8 parts, Flos Lonicerae 10 parts, Rhizoma Imperatae 8 parts.
Above-mentioned a kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then add concentration be 15% saline vexed, rear taking-up, section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with the wine of Rhizoma Imperatae 1 times, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add the water making beating of quality of medicinal material 10 times, after having pulled an oar, poured into by serosity in non iron container, heated and boiled continued after 10 minutes, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill 6 hours, filters, the order number of screen cloth used is 100 orders, collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
The present invention treats the using method of the collutory medicament of toothache: every day 2 times, and ante cibum morning and evening, rinsing the mouth 2-5 minute, after rinsing the mouth in half an hour, can not take food or diet, 7 days courses for the treatment of.
Embodiment 2 one kinds treats the collutory medicament of toothache, is prepared from primarily of following bulk drugs, every part of 5g: Herba Taraxaci 15 parts, Semen Oroxyli 12 parts, Radix Scutellariae 16 parts, Radix Cynanchi Paniculati 12 parts, Herba Asari (entering afterwards) 12 parts, Radix Saposhnikoviae 15 parts, Galla Chinensis 16 parts, halite 15 parts, Folium Isatidis 15 parts, the Rhizoma Anemarrhenae 12 parts, Flos Lonicerae 20 parts, Rhizoma Imperatae 15 parts.
A kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then add concentration be 25% saline vexed, rear taking-up, section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with the wine of Rhizoma Imperatae 3 times, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add the water making beating of quality of medicinal material 16 times, after having pulled an oar, poured into by serosity in non iron container, heated and boiled continued after 20 minutes, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill 10 hours, filters, the order number of screen cloth used is 200 orders, collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
Model case: xxx, female, 46 years old.Main suit: before three months, tooth has slight discomfort, but feels comfortable during tooth clinching, the most within the next few days, on right side there is the dull pain of spontaneous persistence in backteeth, examination of mouth, upper right first obturator of having ground one's teeth in sleep, other tooth no abnormality seens, knocking suffers from tooth sharp ache, and suffering from tooth has loosening.Be diagnosed as the toothache of acute serosity periodontitis.
Use a kind of collutory medicament for the treatment of toothache of the present embodiment gained, every day 2 times, ante cibum morning and evening, rinsing the mouth 2-5 minute, after rinsing the mouth in half an hour, can not take food or diet, 7 days courses for the treatment of.Use two days later, toothache remission, after using one week, patient has a toothache transference cure, and diet recovers normal, recovery from illness.
Embodiment 3 one kinds treats the collutory medicament of toothache, is prepared from primarily of following bulk drugs, every part of 5g: Herba Taraxaci 10 parts, Semen Oroxyli 8 parts, Radix Scutellariae 10 parts, Radix Cynanchi Paniculati 8 parts, Herba Asari (entering afterwards) 9 parts, Radix Saposhnikoviae 10 parts, Galla Chinensis 12 parts, halite 13 parts, Folium Isatidis 11 parts, the Rhizoma Anemarrhenae 9 parts, Flos Lonicerae 12 parts, Rhizoma Imperatae 10 parts.
A kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then add concentration be 17% saline vexed, rear taking-up, section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with the wine of Rhizoma Imperatae 1 times, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add the water making beating of quality of medicinal material 12 times, after having pulled an oar, poured into by serosity in non iron container, heated and boiled continued after 12 minutes, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill 7 hours, filters, the order number of screen cloth used is 120 orders, collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
Model case: xxx, man, 26 years old.Main suit: do not like brushing teeth, often forget, nearly 2 days there is toothache in the right, evening comparatively daytime pain, red tongue tongue is few, and when eating harder and sweet acid or cold and hot food, the pain increased, examination of mouth, right first molar has defect, and there is hole in second molar face in bottom right, has food debris in hole, visit pain, be diagnosed as toothache due to dental caries.
After worn dental caries are bad, use a kind of collutory medicament for the treatment of toothache of the present embodiment gained, every day 2 times, ante cibum morning and evening, rinsing the mouth 2-5 minute, after rinsing the mouth in half an hour, can not take food or diet, 7 days courses for the treatment of.Use after one day, toothache obviously alleviates, and uses after three days, and toothache disappears, and consolidate curative effect uses 2 days, and patient is without malaise symptoms, and toothache is fully recovered, drug withdrawal.
Embodiment 4 one kinds treats the collutory medicament of toothache, is prepared from primarily of following bulk drugs, every part of 5g: Herba Taraxaci 14 parts, Semen Oroxyli 10 parts, Radix Scutellariae 14 parts, Radix Cynanchi Paniculati 10 parts, Herba Asari (entering afterwards) 11 parts, Radix Saposhnikoviae 13 parts, Galla Chinensis 14 parts, halite 14 parts, Folium Isatidis 14 parts, the Rhizoma Anemarrhenae 11 parts, Flos Lonicerae 18 parts, Rhizoma Imperatae 13 parts.
A kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then add concentration be 23% saline vexed, rear taking-up, section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with the wine of Rhizoma Imperatae 3 times, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add the water making beating of quality of medicinal material 14 times, after having pulled an oar, poured into by serosity in non iron container, heated and boiled continued after 18 minutes, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill 9 hours, filters, the order number of screen cloth used is 180 orders, collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
Embodiment 5 one kinds treats the collutory medicament of toothache, is prepared from primarily of following bulk drugs, every part of 6g: Herba Taraxaci 12 parts, Semen Oroxyli 9 parts, Radix Scutellariae 12 parts, Radix Cynanchi Paniculati 9 parts, Herba Asari (entering afterwards) 10 parts, Radix Saposhnikoviae 11.5 parts, Galla Chinensis 13 parts, halite 13.5 parts, Folium Isatidis 12.5 parts, the Rhizoma Anemarrhenae 10 parts, Flos Lonicerae 15 parts, Rhizoma Imperatae 11.5 parts.
A kind of preparation method for the treatment of the collutory medicament of toothache is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then add concentration be 20% saline vexed, rear taking-up, section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with the wine of Rhizoma Imperatae 2 times, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add the water making beating of quality of medicinal material 13 times, after having pulled an oar, poured into by serosity in non iron container, heated and boiled continued after 15 minutes, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill 8 hours, filters, the order number of screen cloth used is 150 orders, collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Taraxaci: base is former: be feverfew Herba Taraxaci, alkali ground Herba Taraxaci or the herb belonging to several plants together.Nature and flavor: bitter, sweet, cold.Gui Jing: return liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Semen Oroxyli: base is former: be the mature seed of Bignoniaceae plant oroxylum indicum.Nature and flavor: bitter, sweet, cool.Gui Jing: return lung, liver, stomach warp.Function cures mainly: removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Radix Scutellariae: base is former: be the root of labiate Radix Scutellariae.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Radix Cynanchi Paniculati: base is former: be the root and rhizome of Asclepiadaceae Cynanchum plant Radix Cynanchi Paniculati.Nature and flavor: pungent, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: removing dampness of dispeling the wind, antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
Herba Asari: base is former: be the herb of aristolochiaceae plant Herba Asari, Seoul Herba Asari or magnificent Herba Asari.Nature and flavor: pungent, temperature.Gui Jing: GUIXIN, lung, kidney channel.Function cures mainly: expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Radix Saposhnikoviae: base is former: be the root of umbelliferae Saposhnikovia divaricata.Nature and flavor: acrid, sweet, warm.Gui Jing: return bladder, liver, spleen channel.Function cures mainly: inducing diaphoresis to dispel wind, and victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Galla Chinensis: base is former: be the insect gall of doubly Aphidiadae insecticide horned gall aphid or melaphis peitan Tsai et Tang formation on the trees such as its host's Fructus rhois chinensis, potanin sumac or Radix Rhois Sinicae.Nature and flavor: sour, puckery, cold.Gui Jing: return lung, large intestine, kidney channel.Function cures mainly: pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, and arresting sweating stops blooding, removing dampness sore.For chronic cough of deficiency lung, lung-heat phlegmatic cough, chronic diarrhea chronic dysentery, night sweat, quenches one's thirst, hemorrhoidal bleeding of having blood in stool, traumatic hemorrhage, carbuncle sore tumefacting virus, Skin wet and rotten.
Halite: base is former: be the crystalline solid of chloride-based halite race mineral halite.Nature and flavor: salty, cold.Gui Jing: GUIXIN, kidney, urinary bladder channel.Function cures mainly: purge heat, removing heat from blood, and improving eyesight is moisturized, and cures mainly hematuria, and spit blood, radula is hemorrhage, conjunctival congestion and swelling pain, the rotten string of wind-eye, toothache, constipation.
Folium Isatidis: base is former: be the dried leaves of cruciferae isatis.Nature and flavor: bitter, cold.Gui Jing: GUIXIN, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
The Rhizoma Anemarrhenae: base is former: be the rhizome of the liliaceous plant Rhizoma Anemarrhenae.Nature and flavor: bitter, sweet, cold.Gui Jing: return lung, stomach, kidney channel.Function cures mainly: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.
Flos Lonicerae: base is former: the flower just opened for caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis or band.Nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Rhizoma Imperatae: base is former: be the dry rhizome of grass Herba Imperatae.Nature and flavor: sweet, cold.Gui Jing: return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.
A kind of clinical practice for the treatment of the collutory medicament (embodiment 5) of toothache of test example 1 gained of the present invention:
447 routine patient with toothache are screened, wherein women 228 example, male 219 example, oldest 62 years old, minimal ages 16 years old, 43.5 years old mean age in oral cavity mouth out-patient department of hospital.Experimenter, all without severe systemic infection and systemic disease, did not take antibacterials in nearly 1 month, wherein gingivitis patients 136 example, patients with periodontitis 117 example, decayed tooth patient 98 example, pulpitis patient 96 example.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group uses products obtained therefrom of the present invention, adopts every day 2 times, sooner or later ante cibum rinsing the mouth 2-5 minute, after rinsing the mouth in half an hour, can not take food or diet, 7 days courses for the treatment of.Matched group uses other collutory to clean the conventional collutorys such as water, Fa Hemu collutory, Li Shidelin collutory as dentistry.Treatments period carries out Continuous Observation to two groups of patients, and record symptom and change, add up two groups of patient treatment situations after the course for the treatment of.
Curative effect situation criterion: effective: the clinical symptom disappearance such as toothache, red swelling of gingiva, chance caloric stimulation is without exception; Effective: the clinical symptoms such as toothache, red swelling of gingiva obviously alleviate, the pain of answering thing to still have acid swollen with caloric stimulation or chew; Invalid: the symptoms such as toothache, redness are unchanged or increase the weight of.
Table 1 liang group patient treatment outcome
Through the treatment of a course for the treatment of, the toothache alleviation situation of two groups of patients is as shown in table 1, experimental group patient, and what the symptoms such as toothache were eliminated has 142 examples (43.7%), patient 178 example (54.8%) that toothache symptom is clearly better, experimental group total effective rate 98.5%; The effective example of matched group of comparing has 38 (31.1%), and effective example has 60 (49.2%), and matched group total effective rate is 80.3%, and the successful for the treatment of toothache is not as experimental group.And the symptom of observing between two groups of patient's operating periods improves situation discovery, the time that experimental group patients symptomatic is eased is short compared with matched group, and the present invention's made collutory medicament instant effect is described.
Rational formula of the present invention, science selection, wherein Herba Taraxaci, Radix Scutellariae, Folium Isatidis heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Semen Oroxyli removing heat from the lung and relieving sorethroat, dispersing the stagnated liver-QI for regulating the stomach; Radix Cynanchi Paniculati dispels the wind removing dampness, antalgesic-antipruritic; Herba Asari expelling wind and cold, understand things pain-stopping; Radix Saposhnikoviae inducing diaphoresis to dispel wind; Galla Chinensis astringe the lung pathogenic fire reducing, arresting sweating hemostasis; Halite purges heat improving eyesight; The Rhizoma Anemarrhenae promotes the production of body fluid and moisturizes; Flos Lonicerae wind-heat dissipating; Rhizoma Imperatae cooling blood for hemostasis, the active component that often kind of medical material has it special, by being used in combination of their science, play the effects such as clearing away heat-fire, understand things pain-stopping, soothing the liver eliminating stagnation, for the toothache that many reasons causes, all there is good pain relieving pain treating effect, and patient can be helped to solve rapidly pain puzzlement.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a collutory medicament for toothache, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Herba Taraxaci 9-15, Semen Oroxyli 6-12, Radix Scutellariae 8-16, Radix Cynanchi Paniculati 6-12, Herba Asari (entering afterwards) 8-12, Radix Saposhnikoviae 8-15, Galla Chinensis 10-16, halite 12-15, Folium Isatidis 10-15, Rhizoma Anemarrhenae 8-12, Flos Lonicerae 10-20, Rhizoma Imperatae 8-15.
2. a kind of collutory medicament for the treatment of toothache as claimed in claim 1, is characterized in that, Herba Taraxaci 10-14, Semen Oroxyli 8-10, Radix Scutellariae 10-14, Radix Cynanchi Paniculati 8-10, Herba Asari (entering afterwards) 9-11, Radix Saposhnikoviae 10-13, Galla Chinensis 12-14, halite 13-14, Folium Isatidis 11-14, Rhizoma Anemarrhenae 9-11, Flos Lonicerae 12-18, Rhizoma Imperatae 10-13.
3. a kind of collutory medicament for the treatment of toothache as claimed in claim 1, is characterized in that, Herba Taraxaci 12, Semen Oroxyli 9, Radix Scutellariae 12, Radix Cynanchi Paniculati 9, Herba Asari (entering afterwards) 10, Radix Saposhnikoviae 11.5, Galla Chinensis 13, halite 13.5, Folium Isatidis 12.5, the Rhizoma Anemarrhenae 10, Flos Lonicerae 15, Rhizoma Imperatae 11.5.
4. a kind of preparation method for the treatment of the collutory medicament of toothache as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) getting Testa Tritici to fry to smoldering, adding and picking the clean Rhizoma Anemarrhenae, fry to yellow, sieve removes Testa Tritici, then it is vexed to add saline, rear taking-up, and section, dries;
(2) Rhizoma Imperatae is picked clean impurity, clean, section, mixes micro-profit thoroughly with wine, is placed in pot Steam by water bath saturating, then takes out and dries;
(3) by other medical materials (except halite, Herba Asari) decontamination, clean, be placed in beater together with step (1) (2) made medical material, add water making beating, after having pulled an oar, serosity is poured in non iron container, after heated and boiled, add Herba Asari, continue to boil 15 minutes, cooling leaves standstill, and filters, and collects filtrate;
(4) halite is picked decontamination, smash to pieces, join while stirring in step (3) made filtrate, homogenizing after stirring, obtains collutory.
5. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, is characterized in that, the concentration of step (1) saline is that (preferred, the concentration of saline is 17-23% to 15-25%; Be more preferably, the concentration of saline is 20%).
6. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, is characterized in that, the amount of step (2) wine is the 1-3 of Rhizoma Imperatae doubly (preferred, the amount of wine is 2 times of Rhizoma Imperatae).
7. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, is characterized in that, step (3) amount of water be the 10-16 of quality of medicinal material doubly (preferred, amount of water be the 12-14 of quality of medicinal material doubly; Be more preferably, amount of water is 13 times of quality of medicinal material).
8. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, it is characterized in that, step (3) heated and boiled continues 10-20 minute, and (heated and boiled continues 12-18 minute; Be more preferably, heated and boiled continues 15 minutes).
9. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, is characterized in that, step (3) cooling leaves standstill 6-10 hour, and (preferred, cooling leaves standstill 7-9 hour; Be more preferably, cooling leaves standstill 8 hours).
10. a kind of preparation method for the treatment of the collutory medicament of toothache as claimed in claim 4, is characterized in that, the order number that step (3) filters screen cloth used is that (preferred, the order number filtering screen cloth used is 120-180 order to 100-200 order; Be more preferably, the order number filtering screen cloth used is 150 orders).
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