CN105031274A - Compound preparation for treating periodontitis and preparation method of compound preparation - Google Patents

Abstract

The invention discloses a compound preparation for treating periodontitis. The compound preparation is prepared from the following main raw materials in parts by weight: 9-15 parts of common nasturtium herbs, 7-14 parts of smallfruit meadowrue herbs, 8-13 parts of sunglo, 10-15 parts of ilex pubescens leaves, 7-12 parts of prostrate cyathula herbs, 9-13 parts of rhizoma alismatis, 10-14 parts of smallflower houndstongue herbs, 8-16 parts of oblongleaf garcinia seed oil, 11-16 parts of osmanthus fragrans, 9-14 parts of bigleaf goldsaxifrage herbs, 7-13 parts of rosa davurica, 6-12 parts of Chinese pear-leaved crabapples, 8-15 parts of common adenostema herbs, 10-13 parts of drosera peltata, 7-15 parts of odontoglossum crispum, 9-12 parts of gooseintestine sarwort herbs and 11-15 parts of radix codonopsis. The compound preparation disclosed by the invention can be used for keeping relatively high drug concentration in a periodontal pocket and has the effects of clearing away heat and toxic materials, cooling blood and relieving pain, astringing to stop bleeding as well as dispelling wind and relieving swelling so as to kill various bacteria in the periodontal pocket and have a favorable effect on treating periodontitis.

Description

The prescription for the treatment of periodontitis and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of prescription and method for making for the treatment of periodontitis.

Background technology

Periodontitis is the chronic inflammatory disease invading gingiva and periodontal tissue, and be a kind of destructive disease, its principal character is the formation of periodontal pocket and the inflammation of bag wall, and frontal resorption and tooth loosen gradually, and it is the main cause causing adult's loss of tooth.Primary disease is many because bacterial plaque, tartar, food impaction, and ill fitting prosthesis, stings wound etc. and cause, various focusing depths represented swelling, makes bacterial plaque pile up simultaneously and increases the weight of, and prolongs by expanding under gingivally on gum.Due to microecological environment under gum, grow the Periodontal Pathogens that virulence is larger in a large number in subgingival plaque, as gingiva bacteroid, intermediate bacillus, spirillums etc., make the increased inflammation of gingiva and expand to prolong, cause periodontal pocket to be formed and frontal resorption, cause periodontitis.

Periodontitis is come to a conclusion as after cancer, cardiovascular and cerebrovascular disease by medical circle, and threatening the third-largest killer of human body health, is also the number one killer of oral health.Some advanced symptoms that periodontitis occurs, also become the principal character that oral cavity subhealth state worsens.Most patients with periodontitis is all along with the symptom of gingival atrophy, and investigation finds, the crowd more than 45 years old, and more than 90% exists gingival atrophy phenomenon in various degree, and gingival atrophy, also one to being considered as irreversible physiology degradation phenomena by medical circle of oral cavity.The direct impact that gingival atrophy brings; exactly as to take care of one's teeth and the natural cover for defense of sub-gingival tissue is opened; various food in oral cavity is caused to remain and dirt; crossed healthy gingiva protection and under invading gum; to brush teeth the oral hygiene dead angle that cannot clean in this routine, accumulation for a long time forms tartar.Tartar is that under gum, various periodontal harmful levels of pathogens grows than indispensable carrier, due to gingival atrophy, and makes anaerobe be grown under gum, spread, attacks the health of gingiva and periodontal tissue for a long time; Malnutrition due to gingiva as previously mentioned simultaneously, under shifting, and then causes the ability of adult oral cavity resist the disease infringement, the result failed with age and significantly, thus causes various gingivitis, periodontitis, pulpitis symptom.

At present, the medicine for the treatment of periodontitis is a lot, publication number CN103520424A(application number 201310469457.2) patent document discloses a kind of Chinese medicine preparation for the treatment of periodontitis, it is made up of following raw material medicaments: Radix Angelicae Pubescentis 20-40 part, Radix Saposhnikoviae 20-40 part, Caulis Lonicerae 20-30 part, Radix Gentianae 20-30 part, Radix Rehmanniae 20-30 part, Cortex Moutan 20-30 part, Herba Schizonepetae 10-20 part, Rhizoma Chuanxiong 10-20 part, Radix Glehniae 8-15 part, Herba Asari 8-15 part, Radix Astragali 8-15 part, Rhizoma Dioscoreae 8-15 part.Publication number CN104547711A(application number 201510034140.5) patent document discloses a kind of Chinese medicine for the treatment of periodontitis, it is made up of following raw material medicaments: Radix rosae multiflorae 30-40 part, Cortex Garciniae oliganthae 20-30 part, Folium corchori 20-30 part, Folium Ligustri Lucidi 10-25 part, Flos Citri Sarcodactylis 10-25 part, Fructus Tritici Levis 10-25 part, Herba Potentillae Chinensis 10-25 part, Rhizoma Et Radix Baphicacanthis Cusiae 10-25 part, Fructus Sophorae 8-12 part, Semen Momordicae 0.5-1 part.Publication number CN103656127A(application number 201310705677.0) patent document discloses a kind of Chinese medicine for the treatment of periodontitis, be made up of the crude drug of following weight: 25 grams, Flos Sophorae, Radix Polygoni Multiflori 25 grams, Fructus Lycii 25 grams, Gypsum Fibrosum 20 grams, Semen Cuscutae 20 grams, Radix Scutellariae 15 grams, Radix Achyranthis Bidentatae 15 grams, Radix Et Rhizoma Rhei 15 grams, Fructus Gardeniae 15 grams, the Radix Angelicae Dahuricae 10 grams, Radix Rehmanniae 10 grams, Radix Scrophulariae 10 grams, Radix Paeoniae Rubra 10 grams, Cortex Lycii 10 grams, Rhizoma Coptidis 10 grams, Cortex Moutan 10 grams, the Radix Paeoniae Alba 10 grams, Cortex Phellodendri 10 grams, the Rhizoma Anemarrhenae 10 grams, Rhizoma Cimicifugae 2 grams, Herba Asari 2 grams.

Current treatment periodontitis, doctor trained in Western medicine many employings Perorally administrable antimicrobial anti-inflammation drugs and local periodontal surgery and topical medication etc., most of Western medicine can only relief of symptoms, is difficult to eradicate, and usually can not obtain gratifying effect, and price is higher, side effect is larger.And periodontal surgery treatment wound is large, patient is generally difficult to accept.And the existing most of effect of Chinese medicine is commercially definite not, lack strict science controlled observation, curative effect is undesirable.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide the prescription for the treatment of periodontitis, prescription of the present invention can make to keep higher drug concentration in periodontal pocket, there is effect of heat-clearing and toxic substances removing, cooling blood and relieving pain, astringing to arrest bleeding, dispelling wind and eliminating swelling, thus the various antibacterials in elimination periodontal pocket, treatment periodontitis has good curative effect.Another object of the present invention is just to provide the preparation method of above-mentioned prescription.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from: Herba Tropaeoli 9-15 part; Moth tree 7-14 part; Usnea 8-13 part; Folium Ilicis Pubescentis 10-15 part; Herba Cyathulae Prostratae 7-12 part; Rhizoma Alismatis 9-13 part; Herba Cynoglossi lanceolati 10-14 part; Olium Garciniae oblongifoliae 8-16 part; Flos Osmanthi Fragrantis 11-16 part; Herba Chrysosplenii Macrophylli 9-14 part; Rose hip 7-13 part; Fructus Mali Asiaticae 6-12 part; Herba Adenostemmatis 8-15 part; Herba Droserae Lunatae 10-13 part; Herba Orchidis Latifoliae 7-15 part; Herba Stellariae Neglectae 9-12 part; Radix Codonopsis 11-15 part.

The prescription for the treatment of periodontitis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Herba Tropaeoli 11-13 part; Moth tree 10-12 part; Usnea 10-12 part; Folium Ilicis Pubescentis 12-14 part; Herba Cyathulae Prostratae 9-11 part; Rhizoma Alismatis 10-12 part; Herba Cynoglossi lanceolati 11-13 part; Olium Garciniae oblongifoliae 11-13 part; Flos Osmanthi Fragrantis 13-15 part; Herba Chrysosplenii Macrophylli 11-13 part; Rose hip 9-11 part; Fructus Mali Asiaticae 8-10 part; Herba Adenostemmatis 11-13 part; Herba Droserae Lunatae 11-12 part; Herba Orchidis Latifoliae 10-12 part; Herba Stellariae Neglectae 10-11 part; Radix Codonopsis 12-14 part.

The prescription for the treatment of periodontitis, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from :herba Tropaeoli 12 parts; Moth sets 11 parts; Usnea 11 parts; Folium Ilicis Pubescentis 13 parts; Herba Cyathulae Prostratae 10 parts; Rhizoma Alismatis 11 parts; Herba Cynoglossi lanceolati 12 parts; Olium Garciniae oblongifoliae 12 parts; Flos Osmanthi Fragrantis 14 parts; Herba Chrysosplenii Macrophylli 12 parts; Rose hip 10 parts; Fructus Mali Asiaticae 9 parts; Herba Adenostemmatis 12 parts; Herba Droserae Lunatae 11.5 parts; Herba Orchidis Latifoliae 11 parts; Herba Stellariae Neglectae 10.5 parts; Radix Codonopsis 13 parts.

Present invention also offers the preparation method prescription of above-mentioned treatment periodontitis being made pharmaceutically acceptable buccal tablet, decoction, pill, tablet and collutory.

The preparation method of the prescription buccal tablet of described treatment periodontitis, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid; mix homogeneously; being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15); be placed in granulation machine and make granule, sterilizing, dry; be placed in pelleter and make buccal tablet, carry out aluminum-plastic packaged.

The preparation method of the prescription buccal tablet of above-mentioned treatment periodontitis, the consumption of the preferred yellow wine of step (2) is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%.

Instructions of taking: containing changing, at every turn get 2, every day 3-5 time, 3 days courses for the treatment of.

The preparation method of the prescription decoction of described treatment periodontitis, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, soak 40-50 minute, filter, be concentrated into 1/2 of original volume, obtain decoction.

Instructions of taking: each 30-50ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 3 days courses for the treatment of.

The preparation method of the prescription pill of described treatment periodontitis, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;

(5) be placed in pot by Mel, slow fire is tempered to thick, adds step (4) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).

The preparation method of the prescription pill of above-mentioned treatment periodontitis, the consumption of the preferred Mel of step (5) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

Instructions of taking: each 10-15 ball, every day 3 times, 3 days courses for the treatment of.

The preparation method of the prescription tablet of described treatment periodontitis, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid; mix homogeneously; filter; being condensed into relative density is 1.10-1.20(25 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15), be placed in granulation machine and make single-size, dry; be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 3 days courses for the treatment of.

The preparation method of the prescription collutory of described treatment periodontitis, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, is more preferably sterilization 15 minutes), sterile packaged.

Instructions of taking: each 20-30ml, every day 3-5 time, 3 days courses for the treatment of.

Technical advantage of the present invention is mainly reflected in:

1, prescription of the present invention can make to keep higher drug concentration in periodontal pocket, has effect of heat-clearing and toxic substances removing, cooling blood and relieving pain, astringing to arrest bleeding, dispelling wind and eliminating swelling, thus eliminates the various antibacterials in periodontal pocket, and treatment periodontitis has good curative effect.

2, the present invention treat the prescription of periodontitis each raw material effect work in coordination with, all medicine compatibilities, can improve rapidly the periodontitis symptoms such as gingival hemorrhage, pain, dental calculus, halitosis.

3, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low, alleviates the economic pressures of patient.

4, the traditional Chinese medicine that the selected multi-flavor of prescription of the present invention is natural forms, harmless to human non-toxic, treating both the principal and secondary aspects of a disease, and determined curative effect, thoroughly cures periodontitis, and more after not easily recur.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1the prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 70g for every part): Herba Tropaeoli 9 parts; Moth sets 7 parts; Usnea 8 parts; Folium Ilicis Pubescentis 10 parts; Herba Cyathulae Prostratae 7 parts; Rhizoma Alismatis 9 parts; Herba Cynoglossi lanceolati 10 parts; Olium Garciniae oblongifoliae 8 parts; Flos Osmanthi Fragrantis 11 parts; Herba Chrysosplenii Macrophylli 9 parts; Rose hip 7 parts; Fructus Mali Asiaticae 6 parts; Herba Adenostemmatis 8 parts; Herba Droserae Lunatae 10 parts; Herba Orchidis Latifoliae 7 parts; Herba Stellariae Neglectae 9 parts; Radix Codonopsis 11 parts.

The preparation method of the prescription buccal tablet of above-mentioned treatment periodontitis, step is as follows:

(1) set by moth, rose hip and Herba Adenostemmatis smash, be placed in glass container, add water (water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soaks 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 3 hours, puts in tank, airtight, Steam by water bath is sucked to wine, takes out, drying, grinds as fine powder, crosses 140 mesh sieves;

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 35 minutes, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, add step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, be condensed into the thick paste that relative density is 1.15, be placed in granulation machine and make granule, sterilizing, dry, be placed in pelleter and make buccal tablet, carry out aluminum-plastic packaged.

Instructions of taking: containing changing, each 2, every day 3-5 time, 3 days courses for the treatment of.

embodiment 2the prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (every part of 30g): Herba Tropaeoli 15 parts; Moth sets 14 parts; Usnea 13 parts; Folium Ilicis Pubescentis 15 parts; Herba Cyathulae Prostratae 12 parts; Rhizoma Alismatis 13 parts; Herba Cynoglossi lanceolati 14 parts; Olium Garciniae oblongifoliae 16 parts; Flos Osmanthi Fragrantis 16 parts; Herba Chrysosplenii Macrophylli 14 parts; Rose hip 13 parts; Fructus Mali Asiaticae 12 parts; Herba Adenostemmatis 15 parts; Herba Droserae Lunatae 13 parts; Herba Orchidis Latifoliae 15 parts; Herba Stellariae Neglectae 12 parts; Radix Codonopsis 15 parts.

The preparation method of the prescription decoction of above-mentioned treatment periodontitis, step is as follows:

(1) set by moth, rose hip and Herba Adenostemmatis smash, be placed in glass container, add water (water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soaks 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 3 hours, puts in tank, airtight, Steam by water bath is sucked to wine, takes out, drying, grinds as fine powder, crosses 140 mesh sieves;

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 35 minutes, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, add step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, soak 45 minutes, filter, be concentrated into 1/2 of original volume, obtain decoction.

Instructions of taking: each 40ml, every day 3 times, 3 days courses for the treatment of.

model case onesame XX, female, 32 years old, people from Accessories during Binzhou, Shandong Province.Approximately there is bitter taste xerostomia, gingival hemorrhage lamp phenomenon without starting under obvious cause the year before, when brushing teeth, gingiva is more easily hemorrhage, and all can ache by tooth when having a meal at every turn, and the nearly section time feels that gingiva distending pain is obvious, chew, pain increases the weight of when swallowing, and has sense of discomfort of significantly dehiscing.So remove examination in hospital, submandibular lymph nodes has tenderness, dehisces slightly limited, lower-left 6 periodontal red swelling of gingiva, and spy is examined easily hemorrhage, has pus to overflow, is diagnosed as periodontitis, treats remission after two weeks, but the later stage easily recurs, and again and again, fails to fully recover always.

Take after the present invention treats 2 courses for the treatment of of prescription (embodiment 2) of periodontitis, gingival swelling and pain obviously alleviates, and dehisces not accommodate gingival hemorrhage, the phenomenon of liquid of suppurating disappears.After continuing to take 2 courses for the treatment of, gingival swelling and pain disappears, and all malaise symptoms disappear.Tracing observation is learnt and is fully recovered, without recurrence.

embodiment 3the prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 60g for every part): Herba Tropaeoli 11 parts; Moth sets 10 parts; Usnea 10 parts; Folium Ilicis Pubescentis 12 parts; Herba Cyathulae Prostratae 9 parts; Rhizoma Alismatis 10 parts; Herba Cynoglossi lanceolati 11 parts; Olium Garciniae oblongifoliae 11 parts; Flos Osmanthi Fragrantis 13 parts; Herba Chrysosplenii Macrophylli 11 parts; Rose hip 9 parts; Fructus Mali Asiaticae 8 parts; Herba Adenostemmatis 11 parts; Herba Droserae Lunatae 11 parts; Herba Orchidis Latifoliae 10 parts; Herba Stellariae Neglectae 10 parts; Radix Codonopsis 12 parts.

The preparation method of the prescription pill of above-mentioned treatment periodontitis, step is as follows:

(1) set by moth, rose hip and Herba Adenostemmatis smash, be placed in glass container, add water (water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soaks 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 3 hours, puts in tank, airtight, Steam by water bath is sucked to wine, takes out, drying, grinds as fine powder, crosses 140 mesh sieves;

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 35 minutes, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, add step (1) gained filtrate, mixing;

(4) join in step (3) gained medicinal liquid by step (2) gained medicated powder, mix homogeneously, being condensed into relative density is 1.20(40 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(5) be placed in pot by Mel, slow fire is tempered to thick, adds step (4) gained medicated powder, fully mixes into ointment thoroughly, makes the pill that diameter is 4mm.

Instructions of taking: each 10 balls, every day 3 times, 3 days courses for the treatment of.

embodiment 4the prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 35g for every part): Herba Tropaeoli 13 parts; Moth sets 12 parts; Usnea 12 parts; Folium Ilicis Pubescentis 14 parts; Herba Cyathulae Prostratae 11 parts; Rhizoma Alismatis 12 parts; Herba Cynoglossi lanceolati 13 parts; Olium Garciniae oblongifoliae 13 parts; Flos Osmanthi Fragrantis 15 parts; Herba Chrysosplenii Macrophylli 13 parts; Rose hip 11 parts; Fructus Mali Asiaticae 10 parts; Herba Adenostemmatis 13 parts; Herba Droserae Lunatae 12 parts; Herba Orchidis Latifoliae 12 parts; Herba Stellariae Neglectae 11 parts; Radix Codonopsis 14 parts.

The preparation method of the prescription tablet of above-mentioned treatment periodontitis, step is as follows:

(1) set by moth, rose hip and Herba Adenostemmatis smash, be placed in glass container, add water (water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soaks 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 3 hours, puts in tank, airtight, Steam by water bath is sucked to wine, takes out, drying, grinds as fine powder, crosses 140 mesh sieves;

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 35 minutes, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, add step (1) gained filtrate, mixing;

(4) join in step (3) gained medicinal liquid by step (2) gained medicated powder, mix homogeneously, filter, being condensed into relative density is 1.15(25 DEG C) thick paste, be placed in granulation machine and make single-size, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2, every day 3 times, 3 days courses for the treatment of.

model case twotownship XX, female, 39 years old, people from Jinan City, Shandong Province.Gingival hemorrhage 5 years when brushing teeth, there is abnormal flavour in oral cavity, occasionally has spontaneous hemorrhage, exacerbation of symptoms in recent years, usually occur gingival hemorrhage when brushing teeth, cold and hot pain is strong, and after chewing feel food, pain is especially serious, so go to see a doctor, tartar (++-+++), gingiva color is red, and tooth 2 degree loosens, gingival recession 3-4mm, the periodontal pyorrhea of some tooth; X sheet checks: dental pattern groove bone bone ridge backform is stuck with paste, and bone hardboard disappears, and serious frontal resorption is to the tip of a root 1/3rd.After treatment, symptom is obviously alleviated, but Relapse rate afterwards, and increase the weight of gradually, be all can alleviate after taking medicine at every turn, but just can recur again in the near future.

Take after the present invention treats 2 courses for the treatment of of prescription (embodiment 4) of periodontitis, gingival swelling and pain obviously alleviates, and abnormal flavour fond of food that is not salty obviously alleviates, and red swelling of gingiva and gingival hemorrhage phenomenon disappear.After continuing to take 2 courses for the treatment of, all malaise symptoms are all obviously alleviated.Later stage follows up a case by regular visits to and learns and fully recover, and does not recur.

embodiment 5the prescription for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Herba Tropaeoli 12 parts; Moth sets 11 parts; Usnea 11 parts; Folium Ilicis Pubescentis 13 parts; Herba Cyathulae Prostratae 10 parts; Rhizoma Alismatis 11 parts; Herba Cynoglossi lanceolati 12 parts; Olium Garciniae oblongifoliae 12 parts; Flos Osmanthi Fragrantis 14 parts; Herba Chrysosplenii Macrophylli 12 parts; Rose hip 10 parts; Fructus Mali Asiaticae 9 parts; Herba Adenostemmatis 12 parts; Herba Droserae Lunatae 11.5 parts; Herba Orchidis Latifoliae 11 parts; Herba Stellariae Neglectae 10.5 parts; Radix Codonopsis 13 parts.

The preparation method of the prescription collutory of above-mentioned treatment periodontitis, step is as follows:

(1) set by moth, rose hip and Herba Adenostemmatis smash, be placed in glass container, add water (water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soaks 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 3 hours, puts in tank, airtight, Steam by water bath is sucked to wine, takes out, drying, grinds as fine powder, crosses 140 mesh sieves;

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 35 minutes, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, add step (1) gained filtrate, mixing;

(4) join in step (3) gained medicinal liquid by step (2) gained medicated powder, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilizes 15 minutes, sterile packaged.

Instructions of taking: each 20-30ml, every day 4 times, 3 days courses for the treatment of.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Herba Tropaeoli: acrid in the mouth, acid, cool in nature.GUIXIN, kidney channel.For the herb of Tropaeolaceae plant nasturtium.Containing lignin, nasturtium glucosinolate.There is heat-clearing and toxic substances removing, effect of cooling blood for hemostasis.For conjunctival congestion and swelling pain, furuncle, spits blood, spitting of blood.

Moth is set: bitter in the mouth, salty, and property is put down.The twig and the fruit that split Pueraria lobota trailing plants maple for Aceraceae plant is long.There is cough-relieving, effect of sore.Cough for new chronic cough, thrush.

Usnea: sweet in the mouth, hardship, property is put down.GUIXIN, kidney, lung meridian.For the thallus of the flat plant Usnea Longissima of Usnea, ring crack Usnea.The lichens filamentous of Usnea Longissima contains barbatic acid, usnic acid, diffractaic acid, ramalic acid, lichenin, Usnea Longissima polysaccharide, everninic acid ethyl ester.The lichens filamentous of ring crack Usnea contains barbatic acid, usnic acid, diffractaic acid.There is expelling phlegm for arresting cough, heat-clearing and toxic substances removing, eliminating dampness and dredging channels, blood-arresting catamenia-regulating, effect of anthelmintic.For expectorant hot temperature malaria, cough with asthma, pulmonary tuberculosis, headache, conjunctival congestion nebula, carbuncle sore tumefacting virus, scrofula, acute mastitis, burn and scald, venom, pathogenic wind-warm arthralgia pain, traumatic injury, fracture, traumatic hemorrhage, spits blood, has blood in stool, metrorrhagia, menoxenia, leucorrhea, ascariasis, schistosomicide.

Folium Ilicis Pubescentis: bitter in the mouth, puckery, cool in nature.Return stomach, lung meridian.For the leaf of holly plant Radix Ilicis Pubescentis.Containing DHAP, hydroquinone, scopoletin, aesculetin, 4-hydroxy-3-methoxy-.alpha.-toluic acid., vomiofliol, Ilex pubescens var. glabra Chang A prime, Radix Ilicis Pubescentis Triterpene Glycosides A.There is clearing away heat and cooling blood, the relation of removing toxic substances and promoting subsidence of swelling.For scalding, traumatic hemorrhage, carbuncle furuncle, acute gangrenous stomatitis.

Herba Cyathulae Prostratae: bitter in the mouth, cool in nature.For the aerial parts of Amaranthaceae Herba Cyathulae Prostratae platymiscium Herba Cyathulae Prostratae.There is heat clearing away, removing toxic substances, effect of dissipating blood stasis.For carbuncle pyogenic infections from tumour or sore, traumatic injury congestive edema, venom.

Rhizoma Alismatis: sweet in the mouth, bitterly disappointed.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.

Herba Cynoglossi lanceolati: bitter in the mouth, cool in nature.Return stomach, kidney channel.For the herb of comfrey little Hua coloured glaze.Containing Australia cynoglossophine and Australia Herba Carpesii Cernui booth alkali.There is heat-clearing and toxic substances removing, effect of inducing diuresis to remove edema.For periodontal abscess, acute nephritis, periodontitis, lower jaw acute lymphadenitis, venom.

Olium Garciniae oblongifoliae: sweet in the mouth, acid, cool in nature.Return stomach warp.For the fatty oil of Garcinia maingayii Fructus Garciniae oblongifoliae and south of the Five Ridges Cortex Garciniae kernel.There is heat-clearing and toxic substances removing, receive effect of sword granulation promoting.For burn, scald, stomatitis, periodontitis, eczema, carbuncle skin ulcer is festered, the not life of new meat.

Flos Osmanthi Fragrantis: acrid in the mouth, warm in nature.For the flower of Oleaceae plants sweet-scented osmanthus.Containing aromatic substance, as decanolactone, α-ionone, alpha, beta-lonone, trans-linalool oxide, cis-linalool oxide, linalool, aldehyde C-9 and β-phellandrene, nerol, Geraniol, dihydro-β-ionone.Have and reduce phlegm, effect of dissipating blood stasis.Ridicule for phlegm retention and cough, hemorrhoidal hamorrhage dysentery, hernia abdominal mass, toothache, halitosis.

Herba Chrysosplenii Macrophylli: bitter in the mouth, puckery, cold in nature.For the herb of saxifragaceae plant great Ye gold waist.Containing Quercetin, leaf stripe and flavone compound.There is heat-clearing and toxic substances removing, cough-relieving, leukorrhagia stopping, effect of convergence granulation promoting.For ecthyma; Scald.

Rose hip: sour in the mouth, hardship, warm in nature.Return liver, spleen, stomach, urinary bladder channel.For the fruit of rosaceous plant Rosa bella, light leaf Rosa bella.Containing organic acid, sugar, pectin, vitamin C, carotenoid, phenoloid and leucoanthocyanidin, anthocyanidin, cachou extract, trace element (calcium, fluorine, magnesium etc.), protein, silver-colored Hibiscus syriacus glycoside, this Herba Ephedrae is tanned booth, agrimonine, Extract of Cimiei fruit and oleanolic acid.There is strengthening the spleen to promote digestion, promoting blood flow to regulate menstruation, the relation of astringing lung-QI and relieving cough.For dyspepsia, inappetence, abdominal distention, diarrhoea, menoxenia, dysmenorrhea, atherosclerosis, the cough of lung knot.

Fructus Mali Asiaticae: sour in the mouth, sweet, warm in nature.GUIXIN, liver, lung meridian.For the fruit of rosaceous plant premium.Containing folic acid.There is expel flatulence and relieve chest stuffiness, promoting the production of body fluid to quench thirst, the relation of relieving pain by regulating middle-JIAO.For phlegm retention food stagnation, chest and diaphragm painful abdominal mass plug, quenches one's thirst, cholera, stomachache of vomiting and diarrhoea, dysentery.

Herba Adenostemmatis: acrid in the mouth, micro-hardship, property is shied.For the herb of feverfew adenostemma laveniaKuntze.Containing multiple kaurane type two circle constituents: mapping-11 Alpha-hydroxy-15 α-acetoxyl group-16-kaurene-19-acid, mapping-11 alpha-dihydroxy--16-kaurene-19-acid, (16R)-mapping-11 Alpha-hydroxy-15-institute generation-19-Kauranoic acid, mapping-11-Alpha-hydroxy-15-oxo-16-kaurene-19-acid, go to the field chrysanthemumic acid A, B, C, D, E, F, G and adenostemma laveniaKuntze glycoside A, B, C, D, E, F, G.There is heat-clearing and toxic substances removing, effect of expelling wind and removing dampness.For cold, fever, icterohepatitis, cough due to lung-heat, laryngopharynx swelling and pain, beriberoid pyretic arthralgia, acute mastitis, carbuncle furuncle, venom.

Herba Droserae Lunatae: sweet in the mouth, pungent, property is put down.Return spleen, stomach, lung meridian.For the herb of Droseraceae plant Herba Droserae Lunatae or light calyx Herba Droserae Lunatae.Containing the naphthoquinone such as plumbagin, droserone constituents.There is wind-expelling pain-stopping, invigorate blood circulation, effect of removing toxic substances.For traumatic injury, lumbar muscle strain, stomachache, flu, laryngopharynx swelling and pain, dysentery, malaria, infantile malnutrition, corneal nebula, scrofula, eczema, scabies.

Herba Orchidis Latifoliae: sweet in the mouth, property is put down.GUIXIN, kidney, stomach warp.For the herb of the wide leaf Herba Orchidis Latifoliae of orchid.Containing saccharide, protein, fat etc.There is tonifying kidney and nourishing yin, the relation of invigorating spleen and reinforcing stomach.For deficiency of YIN consumptive disease heat, irritated thirsty, anorexia, menoxenia.

Herba Stellariae Neglectae: mildly bitter flavor, cool in nature.Return stomach, the heart, Liver Channel.For the herb of pinkwort match Herba stellariae mediae.There is heat-clearing and toxic substances removing, treating stranguria, effect of blood stasis dispelling.For sick pyogenic infections from tumour or sore, scall, mastalgia, hemorrhoid, dysentery, toothache, pyretic stranguria, puerperal abdonimal pain.

Radix Codonopsis: sweet in the mouth, property is put down.Return spleen, lung meridian.For Campanulaceae Radix Codonopsis, the plain dry root spending Radix Codonopsis or radix codonpsis tangshen.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

test examplein order to verify that the present invention treats the curative effect of the prescription (embodiment 5) of periodontitis, do contrast test in June ,-2010 in August, 2009:

General data: screening 250 routine patients with periodontitis, wherein male patient 122 people, female patient 128 people; Minimal ages 18 years old, max age 60 years old, 40.3 years old mean age; 18-30 year 83 people, 31-50 year 89 people, 51-60 year 78 people.Be divided into experimental group and matched group two groups (wherein experimental group 150 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: 1. visit and examine degree of depth > 3mm, have attachment loss > 1mm.2. the visible redness of periodontal pocket surface gingiva or spy are examined rear hemorrhage as seen.3. X-ray film prompting phatnoma bone height reduces.

Usage and dosage: experimental group takes the prescription collutory of gained of the present invention treatment periodontitis, rinsing the mouth, each 20-30ml, every day 4 times, 3 days courses for the treatment of.Matched group uses other medicine (as chlorhexidine acetate collutory, toothache benzydamine granule etc.), and wherein, chlorhexidine acetate collutory: 0.02% solution rinsing the mouth, must not drink.Toothache benzydamine granule: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, double first.

Criterion of therapeutical effect: cure: gingival hemorrhage, pyorrhea swell and ache disappearances, and tooth does not loosen, masticatory function is recovered normally, and depth of pocket decline 2mm, gingival index is 0.Effective: gingival hemorrhage pyorrhea swells and ache alleviation, and odontoseisis alleviates, and can chew soft food, depth of pocket decline 1mm, and gingival index is 1.Invalid: the gingival hemorrhage pyorrhea symptom that swells and ache has no obvious improvement, and odontoseisis is without alleviating, and depth of pocket is without decline.(remarks: gingival index only observes gingiva situation, check the change of gingiva color and matter, and bleeding tendency.Wherein, 0=gums healthy; 1=gingiva mild inflammation: the color of gingiva has MC and Mild edema, spy is examined not hemorrhage).

4 courses for the treatment of of medication treatment, observe latter 6 months for the treatment of.Adopt the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of the prescription of periodontitis, result is as shown in table 1:

Table 1

As can be seen from Table 1, take the present invention and treat the cure rate of the prescription of periodontitis up to 72.67%, effective percentage is up to 98%; And the cure rate taking other drug only 38%, effective percentage also only has 78%.So the successful that the present invention treats the prescription of periodontitis is better than the effect of other drug, cure rate is high, and inefficiency is low, is the comparatively ideal medicament for the treatment of periodontitis, alleviates the misery of patient to a great extent.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the prescription of periodontitis, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Herba Tropaeoli 9-15 part; Moth tree 7-14 part; Usnea 8-13 part; Folium Ilicis Pubescentis 10-15 part; Herba Cyathulae Prostratae 7-12 part; Rhizoma Alismatis 9-13 part; Herba Cynoglossi lanceolati 10-14 part; Olium Garciniae oblongifoliae 8-16 part; Flos Osmanthi Fragrantis 11-16 part; Herba Chrysosplenii Macrophylli 9-14 part; Rose hip 7-13 part; Fructus Mali Asiaticae 6-12 part; Herba Adenostemmatis 8-15 part; Herba Droserae Lunatae 10-13 part; Herba Orchidis Latifoliae 7-15 part; Herba Stellariae Neglectae 9-12 part; Radix Codonopsis 11-15 part.

2. prescription according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Herba Tropaeoli 11-13 part; Moth tree 10-12 part; Usnea 10-12 part; Folium Ilicis Pubescentis 12-14 part; Herba Cyathulae Prostratae 9-11 part; Rhizoma Alismatis 10-12 part; Herba Cynoglossi lanceolati 11-13 part; Olium Garciniae oblongifoliae 11-13 part; Flos Osmanthi Fragrantis 13-15 part; Herba Chrysosplenii Macrophylli 11-13 part; Rose hip 9-11 part; Fructus Mali Asiaticae 8-10 part; Herba Adenostemmatis 11-13 part; Herba Droserae Lunatae 11-12 part; Herba Orchidis Latifoliae 10-12 part; Herba Stellariae Neglectae 10-11 part; Radix Codonopsis 12-14 part.

3. prescription according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Herba Tropaeoli 12 parts; Moth sets 11 parts; Usnea 11 parts; Folium Ilicis Pubescentis 13 parts; Herba Cyathulae Prostratae 10 parts; Rhizoma Alismatis 11 parts; Herba Cynoglossi lanceolati 12 parts; Olium Garciniae oblongifoliae 12 parts; Flos Osmanthi Fragrantis 14 parts; Herba Chrysosplenii Macrophylli 12 parts; Rose hip 10 parts; Fructus Mali Asiaticae 9 parts; Herba Adenostemmatis 12 parts; Herba Droserae Lunatae 11.5 parts; Herba Orchidis Latifoliae 11 parts; Herba Stellariae Neglectae 10.5 parts; Radix Codonopsis 13 parts.

4., according to the arbitrary described prescription of claim 1-3, it is characterized in that, the preparation method of described buccal tablet, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid; mix homogeneously; be condensed into the thick paste that relative density is 1.10-1.20 and (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15), be placed in granulation machine and make granule, (preferred sterilising temp is 75 DEG C-85 DEG C in sterilizing; being more preferably sterilising temp is 80 DEG C); drying, is placed in pelleter and makes buccal tablet, carries out aluminum-plastic packaged.

5. the preparation method of prescription buccal tablet according to claim 4, it is characterized in that: the consumption of the preferred yellow wine of step (2) is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%.

6., according to the arbitrary described prescription of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, soak 40-50 minute, filter, be concentrated into 1/2 of original volume, obtain decoction.

7., according to the arbitrary described prescription of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;

(5) be placed in pot by Mel, slow fire is tempered to thick, adds step (4) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).

8. the preparation method of prescription pill according to claim 7, is characterized in that: the consumption of the preferred Mel of step (5) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

9., according to the arbitrary described prescription of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid; mix homogeneously; filter; be condensed into the thick paste that relative density is 1.10-1.20 and (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15), be placed in granulation machine and make single-size, dry; be pressed into lamellar, sugar coating.

10., according to the arbitrary described prescription of claim 1-3, it is characterized in that, the preparation method of described collutory, step is as follows:

(1) moth tree, rose hip and Herba Adenostemmatis are smashed, be placed in glass container, add water (preferred water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 2-4 doubly, be more preferably water consumption be moth tree, rose hip and Herba Adenostemmatis gross mass 3 times), soak 30 minutes, be placed in marmite, decoct 30-40 minute (preferably decoct 33-37 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(2) Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli are placed in glass container, add yellow wine mix thoroughly (consumption of preferred yellow wine is the 70%-90% of Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass, the consumption being more preferably yellow wine be Herba Cyathulae Prostratae, Flos Osmanthi Fragrantis and Herba Chrysosplenii Macrophylli gross mass 80%), moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Usnea, Rhizoma Alismatis, Fructus Mali Asiaticae and Radix Codonopsis are cleaned, be placed in marmite, soak 30-40 minute, add Herba Tropaeoli, Folium Ilicis Pubescentis, Herba Cynoglossi lanceolati, Herba Droserae Lunatae, Herba Orchidis Latifoliae and Herba Stellariae Neglectae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (1) gained filtrate, mixing;

(4) step (2) gained medicated powder is joined in step (3) gained medicinal liquid, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, is more preferably sterilization 15 minutes), sterile packaged.