CN105031269A - Medicament for treating periodontitis and preparation method of medicament - Google Patents

Abstract

The invention discloses a medicament for treating periodontitis, which is prepared from the following main raw materials in parts by weight: 9-16 parts of rhizoma alismatis, 7-14 parts of acanthopanax, 10-15 parts of hairy holly leaf, 8-16 parts of commelina diffusa, 6-13 parts of Chinese pear-leaved crabapple, 9-14 parts of populus alba leaf, 8-13 parts of orchis, 6-12 parts of rose hip, 7-13 parts of oblongleaf garcinia seed oil, 9-12 parts of spinach beet, 10-16 parts of dodder, 7-15 parts of Chinese usnea, 3-6 parts of daphne giraldii, 10-14 parts of dandelion and 8-12 parts of sheareria nana. The medicament disclosed by the invention has the effects of clearing away heat and purging pathogenic fire, resisting bacteria and diminishing inflammation as well as eliminating swelling and healing sores, is capable of quickly reducing an inflammatory surface and alleviating pain, has a good effect on treating periodontitis, and is free of toxic or side effect.

Description

The medicament for the treatment of periodontitis and method for making

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of medicament and method for making for the treatment of periodontitis.

Background technology

Periodontitis is the chronic infectious disease involving four kinds of Periodontal Supporting Tissue (gingiva, periodontal membrane, alveolar bone and cementum), often causes the inflammatory destruction of Periodontal Supporting Tissue.Periodontitis is mainly divided into chronic periodontitis, aggressive periodontitis, the periodontitis of reflection general disease, gangrenosum acne periodontal disease.

Early stage subjective symptoms is not obvious: patient often only excites the performance of natural disposition gingival hemorrhage or halitosis, similar to symptoms of gingivitis.The swelling of visible gum edge, gum nipple and attached gingiva during inspection, matter are soft, in peony or kermesinus, visit examine easily hemorrhage.Along with the further diffusion of inflammation, occur following symptoms: (1) periodontal pocket is formed: due to the expansion of inflammation, periodontal membrane is destroyed, and alveolar bone absorbs gradually, and gingiva is separated with root of the tooth, makes gingival sulcus deepen and form periodontal pocket.Depth of pocket surveyed by available probe.X-ray can find that alveolar bone has absorption in various degree when checking.(2) periodontal pyorrhea: periodontal pocket wall has ulcer and struvite granulation tissue to be formed, and has purulent secretion to retain in bag, therefore flicking gingiva, visible pyorrhea.And often have halitosis.(3) odontoseisis: because periodontal tissue is destroyed, when particularly frontal resorption increases the weight of, the phenomenon such as odontoseisis, displacement, appears in abutment's tooth forces quantity not sufficient.Now patient often feels unable, the dull pain of occlusion, and gingival hemorrhage and halitosis increase the weight of.When Abwehrkraft des Koepers reduction, periodontal pocket sepage inadequate drainage, periodontal can be formed swollen swollen.Now gingiva is oval projection, rubescent swelling, and tooth mobility increases, and kowtows pain.Patient feels the violent jumping pain in local, sometimes occurs the abscess at multiple position simultaneously, claims multiple periodontal abscess.Now patient can have body temperature rising, general malaise, the symptoms such as submandibular lymph nodes enlargement, tenderness.

Main concurrent following disease: 1, periodontal swelling or multiple periodontal abscess may occur.2, be engaged unable, dull pain, gingival hemorrhage and halitosis to increase the weight of.3, when Abwehrkraft des Koepers reduces, during periodontal pocket sepage inadequate drainage, periodontal can be caused swollen swollen, now gingiva be oval projection, rubescent swelling, tooth mobility increase, kowtow pain, patient feels local and has an intense pain, and sometimes occurs the abscess at multiple position simultaneously, claims multiple periodontal abscess.Now patient can have the symptoms such as body temperature rising, general malaise, submandibular lymph nodes enlargement, tenderness.

At present, the medicine for the treatment of periodontitis is a lot, publication number CN102580035A(application number 201210067685.2) patent document discloses a kind of medicament for the treatment of periodontitis, it is made up of the material of following weight proportioning: Flos Carthami 5-10 part, Rhizoma Cimicifugae 1-5 part, Rhizoma Zingiberis 3-10 part, Caulis Spatholobi 5-10 part, Flos Lonicerae 1-5 part, Radix Aucklandiae 1-5 part, Semen Coicis 5-15 part, Radix Ophiopogonis 1-3 part, Radix Glycyrrhizae 3-5 part, Radix Angelicae Sinensis 1-5 part and Herba Asari 1-5 part.Publication number CN102657743A(application number 201210067702.2) patent document discloses a kind of collutory for the treatment of periodontitis, it is made up of the material of following weight proportioning: Radix Angelicae Pubescentis 5-10 part, Cortex Phellodendri 5-15 part, Rhizoma Cimicifugae 1-5 part, Radix Angelicae Dahuricae 3-8 part, Herba Leonuri 0.1-0。5 parts, Herba Violae 3-10 part, Radix Glycyrrhizae 5-10 part, thickly flutter 3-8 part, Radix Angelicae Sinensis 5-10 part, Herba Asari 10-20 part and/or water 50-100 part.Publication number CN102631448A(application number 201210142843.6) patent document discloses a kind of medicament for the treatment of periodontitis, it is made up by weight of following bulk drugs: Herba Taxilli 3-10 part, Myrrha 10-20 part, Radix Astragali 10-30 part, Herba Hedyotidis Diffusae 10-30 part, Olibanum 5-15 part, Flos Lonicerae 5-10 part, Herba Asari 5-15 part, Herba Plantaginis 10-20 part, Radix Angelicae Dahuricae 10-20 part and Pericarpium Citri Reticulatae 10-20 part.

Current treatment periodontitis, doctor trained in Western medicine many employings Perorally administrable antimicrobial anti-inflammation drugs and local periodontal surgery and topical medication etc., most of Western medicine can only relief of symptoms, is difficult to eradicate, and usually can not obtain gratifying effect, and price is higher, side effect is larger.And periodontal surgery treatment wound is large, patient is generally difficult to accept.And existing Chinese medicine effect is commercially definite not, lacks strict science controlled observation, be difficult to generally obtain desirable therapeutic effect.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide the medicament for the treatment of periodontitis, has effect of clearing away heat-fire, anti-inflammation, detumescence sore, can reduce rapidly inflammation face, ease the pain, treatment periodontitis has good therapeutic effect, has no side effect.Another object of the present invention is just to provide the preparation method of above-mentioned medicament.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Alismatis 9-16 part; Radix Et Caulis Acanthopanacis Senticosi 7-14 part; Folium Ilicis Pubescentis 10-15 part; Horse Auricled Hedyotis Herb 8-16 part; Fructus Mali Asiaticae 6-13 part; Silvery white Folium Populi Pseudo-simonii 9-14 part; Herba Orchidis Latifoliae 8-13 part; Rose hip 6-12 part; Olium Garciniae oblongifoliae 7-13 part; Radix Betae 9-12 part; Semen Cuscutae 10-16 part; Usnea 7-15 part; Daphne giraldii Nitsche 3-6 part; Herba Taraxaci 10-14 part; Herba Sheareriae 8-12 part.

The medicament for the treatment of periodontitis, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Alismatis 12-14 part; Radix Et Caulis Acanthopanacis Senticosi 10-12 part; Folium Ilicis Pubescentis 12-14 part; Horse Auricled Hedyotis Herb 11-13 part; Fructus Mali Asiaticae 9-11 part; Silvery white Folium Populi Pseudo-simonii 11-13 part; Herba Orchidis Latifoliae 10-12 part; Rose hip 8-10 part; Olium Garciniae oblongifoliae 9-11 part; Radix Betae 10-11 part; Semen Cuscutae 12-14 part; Usnea 10-12 part; Daphne giraldii Nitsche 4-5 part; Herba Taraxaci 11-13 part; Herba Sheareriae 9-11 part.

The medicament for the treatment of periodontitis, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from :rhizoma Alismatis 13 parts; Radix Et Caulis Acanthopanacis Senticosi 11 parts; Folium Ilicis Pubescentis 13 parts; Horse Auricled Hedyotis Herb 12 parts; Fructus Mali Asiaticae 10 parts; Silvery white Folium Populi Pseudo-simonii 12 parts; Herba Orchidis Latifoliae 11 parts; Rose hip 9 parts; Olium Garciniae oblongifoliae 10 parts; Radix Betae 10.5 parts; Semen Cuscutae 13 parts; Usnea 11 parts; Daphne giraldii Nitsche 4.5 parts; Herba Taraxaci 12 parts; Herba Sheareriae 10 parts.

Present invention also offers the preparation method medicament of above-mentioned treatment periodontitis being made pharmaceutically acceptable buccal tablet, decoction, pill, tablet and collutory.

The preparation method of the medicament buccal tablet of described treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid; mix homogeneously; being condensed into relative density is 1.10-1.20(40 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15); be placed in granulation machine and make granule, sterilizing, dry; be placed in pelleter and make buccal tablet, carry out aluminum-plastic packaged.

The preparation method of the medicament buccal tablet of above-mentioned treatment periodontitis, step (5) preferably sterilising temp is 75 DEG C-85 DEG C, and being more preferably sterilising temp is 80 DEG C.

Instructions of taking: containing changing, at every turn get 2, every day 3-5 time, 3 days courses for the treatment of.

The preparation method of the medicament decoction of described treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, soak 40-50 minute, filter, be concentrated into 1/2 of original volume, obtain decoction.

Instructions of taking: each 30-50ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 3 days courses for the treatment of.

The preparation method of the medicament pill of described treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, being condensed into relative density is 1.10-1.30(40) thick paste (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;

(6) be placed in pot by Mel, slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).

The preparation method of the medicament pill of above-mentioned treatment periodontitis, the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

Instructions of taking: each 10-15 ball, every day 3 times, 3 days courses for the treatment of.

The preparation method of the medicament tablet of described treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid; mix homogeneously; filter; being condensed into relative density is 1.10-1.20(25 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15), be placed in granulation machine and make single-size, dry; be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 3 days courses for the treatment of.

The preparation method of the medicament collutory of described treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, is more preferably sterilization 15 minutes), sterile packaged.

Instructions of taking: each 20-30ml, every day 3-5 time, 3 days courses for the treatment of.

Technical advantage of the present invention is mainly reflected in:

1, medicament of the present invention has effect of clearing away heat-fire, anti-inflammation, detumescence sore, can reduce rapidly inflammation face, ease the pain, and treatment periodontitis has good therapeutic effect.

2, the traditional Chinese medicine that the selected multi-flavor of medicament of the present invention is natural forms, harmless to human non-toxic, taking convenience, treating both the principal and secondary aspects of a disease, and determined curative effect, thoroughly can cure periodontitis, and more after not easily recur, and to have no side effect.

3, the present invention treat the medicament of periodontitis each raw material effect work in coordination with, all medicine compatibilities, can improve rapidly the periodontitis symptoms such as gingival hemorrhage, pain, dental calculus, halitosis, thoroughly solve periodontitis again and again, cureless difficult medical problem.

4, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1the medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 70g for every part): Rhizoma Alismatis 9 parts; Radix Et Caulis Acanthopanacis Senticosi 7 parts; Folium Ilicis Pubescentis 10 parts; Horse Auricled Hedyotis Herb 8 parts; Fructus Mali Asiaticae 6 parts; Silvery white Folium Populi Pseudo-simonii 9 parts; Herba Orchidis Latifoliae 8 parts; Rose hip 6 parts; Olium Garciniae oblongifoliae 7 parts; Radix Betae 9 parts; Semen Cuscutae 10 parts; Usnea 7 parts; Daphne giraldii Nitsche 3 parts; Herba Taraxaci 10 parts; Herba Sheareriae 8 parts.

The preparation method of the medicament buccal tablet of above-mentioned treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) be placed in glass container by Fructus Mali Asiaticae, rose hip and Usnea, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 35 minutes, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, be condensed into the thick paste that relative density is 1.15, be placed in granulation machine and make granule, sterilizing, dry, be placed in pelleter and make buccal tablet, carry out aluminum-plastic packaged.

Instructions of taking: containing changing, each 2, every day 3-5 time, 3 days courses for the treatment of.

embodiment 2the medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (every part of 30g): Rhizoma Alismatis 16 parts; Radix Et Caulis Acanthopanacis Senticosi 14 parts; Folium Ilicis Pubescentis 15 parts; Horse Auricled Hedyotis Herb 16 parts; Fructus Mali Asiaticae 13 parts; Silvery white Folium Populi Pseudo-simonii 14 parts; Herba Orchidis Latifoliae 13 parts; Rose hip 12 parts; Olium Garciniae oblongifoliae 13 parts; Radix Betae 12 parts; Semen Cuscutae 16 parts; Usnea 15 parts; Daphne giraldii Nitsche 6 parts; Herba Taraxaci 14 parts; Herba Sheareriae 12 parts.

The preparation method of the medicament decoction of above-mentioned treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) be placed in glass container by Fructus Mali Asiaticae, rose hip and Usnea, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 35 minutes, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, soak 45 minutes, filter, be concentrated into 1/2 of original volume, obtain decoction.

Instructions of taking: each 40ml, every day 3 times, 3 days courses for the treatment of.

model case oneconnect XX, female, 57 years old, people from Handan in Hebei province.Occur toothache without starting under obvious inducement before about 4 years, evening is especially serious, and all can ache by tooth when having a meal at every turn, normally cannot chew, can only eat liquid food, so go to see a doctor, be diagnosed as periodontitis, with dental calculus time serious.After toothwash process, oral antibiotic takes a turn for the better after 2 weeks to some extent, but Relapse rate afterwards, and increases the weight of gradually, and companion dehisces discomfort, and dysmasesis companion pain, tooth has foreign body sensation, sometimes even occurs gingival hemorrhage, is all can alleviate after taking medicine at every turn.In recent years through institute of traditional Chinese medicine's acupuncture of being everlasting, illuminator, the physical therapys such as herbal fomentation, treatments period can be alleviated, but it is short to alleviate the persistent period.

Take after the present invention treats 2 courses for the treatment of of medicament (embodiment 2) of periodontitis, conscious toothache sense obviously alleviates, can normal laboratory rodent chow, and dental calculus obviously reduces, and dehisces not accommodate the disappearance of gingival hemorrhage phenomenon.After continuing to take 2 courses for the treatment of, tenderness sense disappears, and all malaise symptoms disappear.Tracing observation to be learnt and to fully recover half a year, without recurrence.

embodiment 3the medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 60g for every part): Rhizoma Alismatis 12 parts; Radix Et Caulis Acanthopanacis Senticosi 10 parts; Folium Ilicis Pubescentis 12 parts; Horse Auricled Hedyotis Herb 11 parts; Fructus Mali Asiaticae 9 parts; Silvery white Folium Populi Pseudo-simonii 11 parts; Herba Orchidis Latifoliae 10 parts; Rose hip 8 parts; Olium Garciniae oblongifoliae 9 parts; Radix Betae 10 parts; Semen Cuscutae 12 parts; Usnea 10 parts; Daphne giraldii Nitsche 4 parts; Herba Taraxaci 11 parts; Herba Sheareriae 9 parts.

The preparation method of the medicament pill of above-mentioned treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) be placed in glass container by Fructus Mali Asiaticae, rose hip and Usnea, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 35 minutes, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) join in step (4) gained medicinal liquid by step (3) gained medicated powder, mix homogeneously, being condensed into relative density is 1.20(40) thick paste, dry, pulverize, obtain medicated powder;

(6) be placed in pot by Mel, slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes the pill that diameter is 4mm.

Instructions of taking: each 10 balls, every day 3 times, 3 days courses for the treatment of.

embodiment 4the medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 35g for every part): Rhizoma Alismatis 14 parts; Radix Et Caulis Acanthopanacis Senticosi 12 parts; Folium Ilicis Pubescentis 14 parts; Horse Auricled Hedyotis Herb 13 parts; Fructus Mali Asiaticae 11 parts; Silvery white Folium Populi Pseudo-simonii 13 parts; Herba Orchidis Latifoliae 12 parts; Rose hip 10 parts; Olium Garciniae oblongifoliae 11 parts; Radix Betae 11 parts; Semen Cuscutae 14 parts; Usnea 12 parts; Daphne giraldii Nitsche 5 parts; Herba Taraxaci 13 parts; Herba Sheareriae 11 parts.

The preparation method of the medicament tablet of above-mentioned treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) be placed in glass container by Fructus Mali Asiaticae, rose hip and Usnea, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 35 minutes, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) join in step (4) gained medicinal liquid by step (3) gained medicated powder, mix homogeneously, filter, being condensed into relative density is 1.15(25 DEG C) thick paste, be placed in granulation machine and make single-size, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2, every day 3 times, 3 days courses for the treatment of.

model case twohuaihe River XX, man, 39 years old, people from Dezhou City Shandong Province.Gingival hemorrhage when patient brushes teeth in this year often, with halitosis, nearly January, lower labial teeth place had pyorrhea to go out, and chewed to feel pain after food, and feel mild pain when starting to chew, gradually pain gradually increases the weight of.So remove examination in hospital, tartar 2 degree, kowtow pain +++, root tip is red and swollen, lays one's hand on pain, has fluctuation; Red swelling of gingiva, gently leans out blood, and deep periodontal pocket is about 4-5mm, inside has pus, and the root face of spy is coarse tartar; Loosen 2 degree; X-ray inspection AQL absorbs and reaches root long about 1/3.Diagnosis position periodontitis, without obviously alleviating after treatment repeatedly.

Take after the present invention treats 2 courses for the treatment of of medicament (embodiment 4) of periodontitis, symptom obviously alleviates, and gingival swelling and pain sense obviously alleviates, and during laboratory rodent chow, pain is not obvious, and red swelling of gingiva and gingival hemorrhage phenomenon disappear, and odontoseisis is alleviated.After continuing to take 2 courses for the treatment of, all malaise symptoms are all obviously alleviated.Later stage follows up a case by regular visits to and learns and fully recover, and the state of an illness does not recur.

embodiment 5the medicament for the treatment of periodontitis, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Rhizoma Alismatis 13 parts; Radix Et Caulis Acanthopanacis Senticosi 11 parts; Folium Ilicis Pubescentis 13 parts; Horse Auricled Hedyotis Herb 12 parts; Fructus Mali Asiaticae 10 parts; Silvery white Folium Populi Pseudo-simonii 12 parts; Herba Orchidis Latifoliae 11 parts; Rose hip 9 parts; Olium Garciniae oblongifoliae 10 parts; Radix Betae 10.5 parts; Semen Cuscutae 13 parts; Usnea 11 parts; Daphne giraldii Nitsche 4.5 parts; Herba Taraxaci 12 parts; Herba Sheareriae 10 parts.

The preparation method of the medicament collutory of above-mentioned treatment periodontitis, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 25 minutes, filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct 35 minutes, filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) be placed in glass container by Fructus Mali Asiaticae, rose hip and Usnea, add yellow wine and mix thoroughly, moistening 3 hours, puts in tank, and airtight, Steam by water bath is sucked to wine, takes out, dry, grinds as fine powder, crosses 140 mesh sieves;

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 35 minutes, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil 35 minutes at every turn, twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) join in step (4) gained medicinal liquid by step (3) gained medicated powder, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilizes 15 minutes, sterile packaged.

Instructions of taking: each 20-30ml, every day 4 times, 3 days courses for the treatment of.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Rhizoma Alismatis: sweet in the mouth, bitterly disappointed.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, micro-hardship, warm in nature.Return spleen, kidney, heart channel.For dry root and rhizome or the stem of Araliaceae Radix Et Caulis Acanthopanacis Senticosi.There is replenishing QI to invigorate the spleen, effect of tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.

Folium Ilicis Pubescentis: bitter in the mouth, puckery, cool in nature.Return stomach, lung meridian.For the leaf of holly plant Radix Ilicis Pubescentis.Containing DHAP, hydroquinone, scopoletin, aesculetin, 4-hydroxy-3-methoxy-.alpha.-toluic acid., vomiofliol, Ilex pubescens var. glabra Chang A prime, Radix Ilicis Pubescentis Triterpene Glycosides A.There is clearing away heat and cooling blood, the relation of removing toxic substances and promoting subsidence of swelling.For scalding, traumatic hemorrhage, carbuncle furuncle, acute gangrenous stomatitis.

Horse Auricled Hedyotis Herb: bitter in the mouth, cold in nature.For the herb of Commelianaceae plant meal bag grass.Containing n-Octacosanol, myricyl alcohol, positive three undecyl alcohols, are shown in sterol, cupreol, campesterol and benzyladenine, and containing delphinidin-3-p-coumaric acid glycoside.There is heat-clearing and toxic substances removing, the relation of inducing diuresis to remove edema.For calentura heating, excessive thirst, laryngopharynx swelling and pain, hematodiarrhoea, pyretic stranguria, hemorrhoid, furuncle carbuncle, snake bite and insect sting.

Fructus Mali Asiaticae: sour in the mouth, sweet, warm in nature.GUIXIN, liver, lung meridian.For the fruit of rosaceous plant premium.Containing folic acid.There is expel flatulence and relieve chest stuffiness, promoting the production of body fluid to quench thirst, the relation of relieving pain by regulating middle-JIAO.For phlegm retention food stagnation, chest and diaphragm painful abdominal mass plug, quenches one's thirst, cholera, stomachache of vomiting and diarrhoea, dysentery.

Silvery white Folium Populi Pseudo-simonii: bitter in the mouth, cold in nature.Return lung meridian.For the leaf of Salicaceous Plants white poplar.Containing O-β-D-glucopyranosyl-9-β-D-RIBOSE base dihydro Semen Maydis purine, O-β-D glucopyranosyl Semen Maydis purine, O-β-D-glucopyranosyl dihydro Semen Maydis purine, the different lariciresinol one of dextrorotation one single-β-D-glucopyanoside.There is relieving cough and asthma, the relation of reducing phlegm and fever.For cough, asthma.

Herba Orchidis Latifoliae: sweet in the mouth, property is put down.GUIXIN, kidney, stomach warp.For the herb of the wide leaf Herba Orchidis Latifoliae of orchid.Containing saccharide, protein, fat etc.There is tonifying kidney and nourishing yin, the relation of invigorating spleen and reinforcing stomach.For deficiency of YIN consumptive disease heat, irritated thirsty, anorexia, menoxenia.

Rose hip: sour in the mouth, hardship, warm in nature.Return liver, spleen, stomach, urinary bladder channel.For the fruit of rosaceous plant Rosa bella, light leaf Rosa bella.Containing organic acid, sugar, pectin, vitamin C, carotenoid, phenoloid and leucoanthocyanidin, anthocyanidin, cachou extract, trace element (calcium, fluorine, magnesium etc.), protein, silver-colored Hibiscus syriacus glycoside, this Herba Ephedrae is tanned booth, agrimonine, Extract of Cimiei fruit and oleanolic acid.There is strengthening the spleen to promote digestion, promoting blood flow to regulate menstruation, the relation of astringing lung-QI and relieving cough.For dyspepsia, inappetence, abdominal distention, diarrhoea, menoxenia, dysmenorrhea, atherosclerosis, the cough of lung knot.

Olium Garciniae oblongifoliae: sweet in the mouth, acid, cool in nature.Return stomach warp.For the fatty oil of Garcinia maingayii Fructus Garciniae oblongifoliae and south of the Five Ridges Cortex Garciniae kernel.There is heat-clearing and toxic substances removing, receive effect of sword granulation promoting.For burn, scald, stomatitis, periodontitis, eczema, carbuncle skin ulcer is festered, the not life of new meat.

Radix Betae: sweet in the mouth, hardship, cold in nature.Return lung, kidney, large intestine channel.For chenopod Radix Betae Ji stem, the leaf of Chard dish.There is heat-clearing and toxic substances removing, effect of clots absorbing hemostasis.For time row calentura, hemorrhoid, measles is sent out smooth thoroughly, spits blood, pyretic toxicity dysentery, amenorrhea, stranguria with turbid discharge, carbuncle, traumatic injury, and snakeworm hinders.

Semen Cuscutae: sweet in the mouth, warm in nature.Return liver,kidney,spleen warp.For the dry mature seed of convolvulus cuscuta plant.There is nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, effect of antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.

Usnea: sweet in the mouth, hardship, property is put down.GUIXIN, kidney, lung meridian.For the thallus of the flat plant Usnea Longissima of Usnea, ring crack Usnea.The lichens filamentous of Usnea Longissima contains barbatic acid, usnic acid, diffractaic acid, ramalic acid, lichenin, Usnea Longissima polysaccharide, everninic acid ethyl ester.The lichens filamentous of ring crack Usnea contains barbatic acid, usnic acid, diffractaic acid.There is expelling phlegm for arresting cough, heat-clearing and toxic substances removing, eliminating dampness and dredging channels, blood-arresting catamenia-regulating, effect of anthelmintic.For expectorant hot temperature malaria, cough with asthma, pulmonary tuberculosis, headache, conjunctival congestion nebula, carbuncle sore tumefacting virus, scrofula, acute mastitis, burn and scald, venom, pathogenic wind-warm arthralgia pain, traumatic injury, fracture, traumatic hemorrhage, spits blood, has blood in stool, metrorrhagia, menoxenia, leucorrhea, ascariasis, schistosomicide.

Daphne giraldii Nitsche: bitter in the mouth, pungent, warm in nature.Slightly poisonous.For root bark and the peel of stem of Isolated From Thymelaeaceae Species Daphne Giraldii Nitsche.Containing daphnetin A, 7,8-dihydroxy coumarin-7-β glycoside and daphnetin B.There is wind-damp dispelling, effect of promoting blood circulation and stopping pain.For rheumatic arthralgia, arthritis, rheumatoid arthritis.

Herba Taraxaci: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.For feverfew Herba Taraxaci, alkali ground Herba Taraxaci or the dry herb belonging to several plants together.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, enterodynia, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Sheareriae: bitter in the mouth, property is put down.For feverfew Herba Sheareriae belongs to the herb of Herba Sheareriae.There is heat-clearing and toxic substances removing, inducing diuresis to remove edema, effect of dispelling wind.For edema, innominate toxic swelling, headache due to pathogenic wind-heat.

test examplein order to verify that the present invention treats the curative effect of the medicament (embodiment 5) of periodontitis, do contrast test in August ,-2010 in June, 2009:

General data: screening 260 routine patients with periodontitis, wherein male patient 122 people, female patient 138 people; Minimal ages 17 years old, max age 60 years old, 41.6 years old mean age; 17-30 year 93 people, 31-50 year 99 people, 51-60 year 68 people.Be divided into experimental group and matched group two groups (wherein experimental group 160 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: 1. visit and examine degree of depth > 3mm, have attachment loss > 1mm.2. the visible redness of periodontal pocket surface gingiva or spy are examined rear hemorrhage as seen.3. X-ray film prompting phatnoma bone height reduces.

Usage and dosage: experimental group takes the medicament collutory of gained of the present invention treatment periodontitis, rinsing the mouth, each 20-30ml, every day 4 times, 3 days courses for the treatment of.Matched group uses other medicine (as chlorhexidine acetate collutory, toothache benzydamine granule etc.), and wherein, chlorhexidine acetate collutory: 0.02% solution rinsing the mouth, must not drink.Toothache benzydamine granule: boiled water is taken after mixing it with water, one time 1 bag, 3 times on the one, double first.

Criterion of therapeutical effect: cure: gingival hemorrhage, pyorrhea swell and ache disappearances, and tooth does not loosen, masticatory function is recovered normally, and depth of pocket decline 2mm, gingival index is 0.Effective: gingival hemorrhage pyorrhea swells and ache alleviation, and odontoseisis alleviates, and can chew soft food, depth of pocket decline 1mm, and gingival index is 1.Invalid: the gingival hemorrhage pyorrhea symptom that swells and ache has no obvious improvement, and odontoseisis is without alleviating, and depth of pocket is without decline.(remarks: gingival index only observes gingiva situation, check the change of gingiva color and matter, and bleeding tendency.Wherein, 0=gums healthy; 1=gingiva mild inflammation: the color of gingiva has MC and Mild edema, spy is examined not hemorrhage).

4 courses for the treatment of of medication treatment, observe latter 6 months for the treatment of.Adopt the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of the medicament of periodontitis, result is as shown in table 1:

Table 1

As can be seen from Table 1, take the present invention and treat the cure rate of the medicament of periodontitis up to 73.75%, effective percentage is up to 98.13%; And the cure rate taking other drug only 41%, effective percentage also only has 81%, and inefficiency is up to 19%.So the successful that the present invention treats the medicament of periodontitis is better than the effect of other drug.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the medicament of periodontitis, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Rhizoma Alismatis 9-16 part; Radix Et Caulis Acanthopanacis Senticosi 7-14 part; Folium Ilicis Pubescentis 10-15 part; Horse Auricled Hedyotis Herb 8-16 part; Fructus Mali Asiaticae 6-13 part; Silvery white Folium Populi Pseudo-simonii 9-14 part; Herba Orchidis Latifoliae 8-13 part; Rose hip 6-12 part; Olium Garciniae oblongifoliae 7-13 part; Radix Betae 9-12 part; Semen Cuscutae 10-16 part; Usnea 7-15 part; Daphne giraldii Nitsche 3-6 part; Herba Taraxaci 10-14 part; Herba Sheareriae 8-12 part.

2. medicament according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Alismatis 12-14 part; Radix Et Caulis Acanthopanacis Senticosi 10-12 part; Folium Ilicis Pubescentis 12-14 part; Horse Auricled Hedyotis Herb 11-13 part; Fructus Mali Asiaticae 9-11 part; Silvery white Folium Populi Pseudo-simonii 11-13 part; Herba Orchidis Latifoliae 10-12 part; Rose hip 8-10 part; Olium Garciniae oblongifoliae 9-11 part; Radix Betae 10-11 part; Semen Cuscutae 12-14 part; Usnea 10-12 part; Daphne giraldii Nitsche 4-5 part; Herba Taraxaci 11-13 part; Herba Sheareriae 9-11 part.

3. medicament according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Rhizoma Alismatis 13 parts; Radix Et Caulis Acanthopanacis Senticosi 11 parts; Folium Ilicis Pubescentis 13 parts; Horse Auricled Hedyotis Herb 12 parts; Fructus Mali Asiaticae 10 parts; Silvery white Folium Populi Pseudo-simonii 12 parts; Herba Orchidis Latifoliae 11 parts; Rose hip 9 parts; Olium Garciniae oblongifoliae 10 parts; Radix Betae 10.5 parts; Semen Cuscutae 13 parts; Usnea 11 parts; Daphne giraldii Nitsche 4.5 parts; Herba Taraxaci 12 parts; Herba Sheareriae 10 parts.

4., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described buccal tablet, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid; mix homogeneously; be condensed into the thick paste that relative density is 1.10-1.20 and (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15); be placed in granulation machine and make granule, sterilizing, dry; be placed in pelleter and make buccal tablet, carry out aluminum-plastic packaged.

5. the preparation method of medicament buccal tablet according to claim 4, is characterized in that: step (5) preferably sterilising temp is 75 DEG C-85 DEG C, and being more preferably sterilising temp is 80 DEG C.

6., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, soak 40-50 minute, filter, be concentrated into 1/2 of original volume, obtain decoction.

7., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;

(6) be placed in pot by Mel, slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).

8. the preparation method of medicament pill according to claim 7, is characterized in that: the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

9., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid; mix homogeneously; filter; be condensed into the thick paste that relative density is 1.10-1.20 and (be preferably condensed into the thick paste that relative density is 1.13-1.17; be more preferably and be condensed into the thick paste that relative density is 1.15), be placed in granulation machine and make single-size, dry; be pressed into lamellar, sugar coating.

10., according to the arbitrary described medicament of claim 1-3, it is characterized in that, the preparation method of described collutory, step is as follows:

(1) cleaned by Herba Taraxaci, decoct with water 2 times, each decoction 20-30 minute (preferably each decoction 23-27 minute, is more preferably each decoction 25 minutes), filters, merging filtrate;

(2) by Rhizoma Alismatis and Radix Et Caulis Acanthopanacis Senticosi section, be placed in glass container, add step (1) gained filtrate, soak 30 minutes, be placed in marmite, decoct and (preferably decoct 33-37 minute in 30-40 minute, be more preferably decoction 35 minutes), filter, add Olium Garciniae oblongifoliae, stir, be concentrated into 1/2 of original volume;

(3) Fructus Mali Asiaticae, rose hip and Usnea are placed in glass container, add yellow wine and mix thoroughly, moistening 2-4 hour, put in tank, airtight, Steam by water bath is sucked to wine, takes out, dry, grind as fine powder, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(4) horse Auricled Hedyotis Herb, Herba Orchidis Latifoliae, Semen Cuscutae, Daphne giraldii Nitsche and Herba Sheareriae are cleaned, be placed in marmite, soak 30-40 minute, add Folium Ilicis Pubescentis, silvery white Folium Populi Pseudo-simonii and Radix Betae, decoct twice, boil at every turn and (preferably boil 33-37 minute in 30-40 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges, and adds step (2) gained filtrate, mixing;

(5) step (3) gained medicated powder is joined in step (4) gained medicinal liquid, mix homogeneously, filter, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferably sterilization 13-17 minute, is more preferably sterilization 15 minutes), sterile packaged.