CN104815230A - Mouthwash for treating chronic periodontitis - Google Patents

Abstract

The invention provides a mouthwash for treating chronic periodontitis, which includes following raw materials: radix melastoma dodecandrum, acanthopanax lasiogyne root bark, symplocos sumuntia leaves, monochasma sheareri, coptis chinensis, achyranthes bidentata, eriocaulon buergerianum, paenoy bark, white peony roots, rheum franzenbachii, achillea sibirca, aster ageratoides, cistanche deserticola, rhizoma cimicifugae, radix angelicae, smoked plum, radix scrophulariae, honeysuckles, thlaspi arvense, coix seeds and liquorice. The mouthwash is simple in preparation method, is good in compliance, is definite in curative effect, is less in side effect and is valuable to popularize.

Description

The gargarism for the treatment of chronic periodontitis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of gargarism being used for the treatment of chronic periodontitis.

Background technology

Chronic periodontitis is most commonly in adult, in slowly increasing the weight of, but also can there is intermittent active stage in primary disease, often further developed by gingivitis, as gingivitis fails to treat in time, inflammation can be diffused into periodontal membrane, alveolar bone and cementum by gingiva to deep layer and develop into chronic periodontitis.

Primary Care chronic periodontitis, removes soil all in oral cavity as far as possible, comprises the cooperation completely that the oral hygiene of patient own is clean, toothbrush and dental floss etc., burnisher proper use of.Then with the toothwash of full mouth ultrasound, striking off and root of the tooth planification of periodontal pouch deep calculus, removes bad breast multiple thing, Occlusal interference etc.Mechanical means removes bacterial plaque, tartar, and sickness rate is high, and the course for the treatment of is long, weak curative effect, and consequence is serious.Treat very thorny, majority can not accept the long period and take Western medicine.The chronic toxicity of chemicals, often make patient give up halfway, thus curative effect is poor.

Modern medicine thinks that chronic periodontitis is that dynamic equilibrium between bacteria attack and host defense is broken caused chronic infectious disease, antibacterial plays key player in its morbidity, but the effect of systemic factor also can not be ignored, some systemic factors such as endocrine disturbance, immunodeficiency etc. all can reduce host defense and repair ability, thus the generation causing disease or the progress aggravated one's illness.In current clinical practice, mainly topical therapeutic is taked to periodontitis, as scaling, scrape control, periodontal surgery etc., namely external used medicine controls local pathogenic bacterium are aided with by mechanical means, there is no effective measures and improve host immune state and resistance against diseases, the part cause of disease is more complicated, there is weak curative effect after patients with periodontitis conventional therapy that the state of an illness is heavier, a difficult problem that the state of an illness easily recurs.Therefore in therapeutics, now and the in the future vital task of a period of time, find one can effectively resist whole body risk factor, improve the Therapeutic Method of all host resistance against diseases, make the treatment of chronic periodontitis can for local and systemic factor is worked along both lines, synergism, make every effort to significantly improve chronic periodontitis curative effect, for thisly having a strong impact on the commonly encountered diseases of human health, the treatment of frequently-occurring disease brings new breakthrough.

As the rarity of traditional medicine, ancient Chinese medicine is early recognized periodontitis.Chronic periodontitis belongs to the traditional Chinese medical science, and " gingival atrophy, tooth moves, gum erosion " category.Control according to differential diagnosis in tcm opinion, chronic periodontitis Etiological is stomach internal organs accumulated heat card, and deficiency of kidney-YIN is demonstrate,proved, and deficiency-weakness of spleen-QI card causes.Through saying: " bone of kidney ", " tooth being the surplus of the bone "." tooth is after kidney, and gum is the network of stomach." the nourishing that visible, tooth relies the filling of kidney liquid, gum relies stomach Tianjin.The whether strong function prosperity and decline depending on kidney, stomach of tooth, gum.Kidney essense is sufficient, and stomach Tianjin is vigorous, then tooth obtains it and supports and firm color pool; Gum obtains its profit and red and color is fresh.Kidney liquid is not enough, and tooth is become homeless to support and then loosened ulceration, and color is withered not damp; Gastrointestinal intenseness of heat, stomach Tianjin is hindered, and gum is become homeless and moistened then congestion and swelling pain, and drying is not fresh, based on heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, helps with blood circulation promoting and blood stasis dispelling, realizes the treatment to chronic periodontitis.The present invention is exactly a kind of gargarism being used for the treatment of chronic periodontitis proposed on this basis, and its method is easy, compliance good, determined curative effect, side reaction are few, is worthy of popularization.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of gargarism being used for the treatment of chronic periodontitis, and its method is easy, compliance good, determined curative effect, side reaction are few, is worthy of popularization.

For solving the problems of the technologies described above, the invention provides a kind of gargarism being used for the treatment of chronic periodontitis, its crude drug comprises Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Herba monochasmatis, Rhizoma Coptidis, Radix Achyranthis Bidentatae, Flos Eriocauli, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Radix Scrophulariae, Flos Lonicerae, Herba Patriniae, Semen Coicis and Radix Glycyrrhizae.

Wherein, in described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 5g ~ 15g, Radix Acanthopanacis Trifoliati 5g ~ 15g, Folium Symplocoris Caudatae 1g ~ 5g, Herba monochasmatis 10g ~ 20g, Rhizoma Coptidis 25g ~ 35g, Radix Achyranthis Bidentatae 10g ~ 20g, Flos Eriocauli 5g ~ 15g, Du's Cortex Moutan 10g ~ 20g, Radix Paeoniae Alba 10g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, achillea millefolium 5g ~ 15g, Herba Asteris Ageratoidis 5g ~ 15g, Herba Cistanches 10g ~ 20g, Rhizoma Cimicifugae 5g ~ 15g, Radix Angelicae Dahuricae 15g ~ 25g, Fructus Mume 1g ~ 5g, Radix Scrophulariae 5g ~ 15g, Flos Lonicerae 25g ~ 35g, Herba Patriniae 10g ~ 20g, Semen Coicis 10g ~ 20g and Radix Glycyrrhizae 5g ~ 15g.

Wherein, in described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 8g ~ 12g, Radix Acanthopanacis Trifoliati 8g ~ 12g, Folium Symplocoris Caudatae 2g ~ 4g, Herba monochasmatis 13g ~ 17g, Rhizoma Coptidis 28g ~ 32g, Radix Achyranthis Bidentatae 13g ~ 17g, Flos Eriocauli 8g ~ 12g, Du's Cortex Moutan 13g ~ 17g, Radix Paeoniae Alba 13g ~ 17g, Radix et Rhizoma Rhei Franzenbachii 18g ~ 22g, achillea millefolium 8g ~ 12g, Herba Asteris Ageratoidis 8g ~ 12g, Herba Cistanches 13g ~ 17g, Rhizoma Cimicifugae 8g ~ 12g, Radix Angelicae Dahuricae 18g ~ 22g, Fructus Mume 2g ~ 4g, Radix Scrophulariae 8g ~ 12g, Flos Lonicerae 28g ~ 32g, Herba Patriniae 13g ~ 17g, Semen Coicis 13g ~ 17g and Radix Glycyrrhizae 8g ~ 12g.

Wherein, in described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 10g, Radix Acanthopanacis Trifoliati 10g, Folium Symplocoris Caudatae 3g, Herba monochasmatis 15g, Rhizoma Coptidis 30g, Radix Achyranthis Bidentatae 15g, Flos Eriocauli 10g, Du's Cortex Moutan 15g, Radix Paeoniae Alba 15g, Radix et Rhizoma Rhei Franzenbachii 20g, achillea millefolium 10g, Herba Asteris Ageratoidis 10g, Herba Cistanches 15g, Rhizoma Cimicifugae 10g, Radix Angelicae Dahuricae 20g, Fructus Mume 3g, Radix Scrophulariae 10g, Flos Lonicerae 30g, Herba Patriniae 15g, Semen Coicis 15g and Radix Glycyrrhizae 10g.

Present invention also offers the preparation method of above-mentioned gargarism, it comprises:

The first step, by Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Rhizoma Coptidis, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Flos Lonicerae, Herba Patriniae and Semen Coicis, is ground into fine powder respectively, mix by above-mentioned weight portion, adding relative to mixture quality 3 ~ 5 times of determining alcohols is that 70% alcohol heating reflux extracts 1 ~ 3 time, each 1 ~ 2 hour, merge extractive liquid, filter, decompression filtrate recycling ethanol, concentrated removing ethanol, obtains and gets dry extract, be ground into powder, cross 20 mesh sieves;

Second step, crude drug under remainder, is ground into fine powder respectively, mix by above-mentioned weight portion, add the water of mixture 1 ~ 3 times amount obtained relative to this step, heating extraction 2 times, extracts 30 ~ 45 minutes at every turn, 2 extracting solution are merged and leaves standstill, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves;

3rd step, the powder mixing first step and second step obtained, adds the deionized water of 8 ~ 12 times relative to mixture quality, obtains gargarism, conventional sterilant, bottling.

Beneficial effect of the present invention:

The gargarism being used for the treatment of chronic periodontitis provided by the invention, its method is easy, compliance good, determined curative effect, side reaction are few, is worthy of popularization.

Detailed description of the invention

The invention provides a kind of gargarism being used for the treatment of chronic periodontitis, its crude drug comprises Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Herba monochasmatis, Rhizoma Coptidis, Radix Achyranthis Bidentatae, Flos Eriocauli, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Radix Scrophulariae, Flos Lonicerae, Herba Patriniae, Semen Coicis and Radix Glycyrrhizae.

Further preferably, the gargarism being used for the treatment of chronic periodontitis described in is only made up of above-mentioned raw materials medicine.

In described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 5g ~ 15g, Radix Acanthopanacis Trifoliati 5g ~ 15g, Folium Symplocoris Caudatae 1g ~ 5g, Herba monochasmatis 10g ~ 20g, Rhizoma Coptidis 25g ~ 35g, Radix Achyranthis Bidentatae 10g ~ 20g, Flos Eriocauli 5g ~ 15g, Du's Cortex Moutan 10g ~ 20g, Radix Paeoniae Alba 10g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, achillea millefolium 5g ~ 15g, Herba Asteris Ageratoidis 5g ~ 15g, Herba Cistanches 10g ~ 20g, Rhizoma Cimicifugae 5g ~ 15g, Radix Angelicae Dahuricae 15g ~ 25g, Fructus Mume 1g ~ 5g, Radix Scrophulariae 5g ~ 15g, Flos Lonicerae 25g ~ 35g, Herba Patriniae 10g ~ 20g, Semen Coicis 10g ~ 20g and Radix Glycyrrhizae 5g ~ 15g.

Further preferably, in described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 8g ~ 12g, Radix Acanthopanacis Trifoliati 8g ~ 12g, Folium Symplocoris Caudatae 2g ~ 4g, Herba monochasmatis 13g ~ 17g, Rhizoma Coptidis 28g ~ 32g, Radix Achyranthis Bidentatae 13g ~ 17g, Flos Eriocauli 8g ~ 12g, Du's Cortex Moutan 13g ~ 17g, Radix Paeoniae Alba 13g ~ 17g, Radix et Rhizoma Rhei Franzenbachii 18g ~ 22g, achillea millefolium 8g ~ 12g, Herba Asteris Ageratoidis 8g ~ 12g, Herba Cistanches 13g ~ 17g, Rhizoma Cimicifugae 8g ~ 12g, Radix Angelicae Dahuricae 18g ~ 22g, Fructus Mume 2g ~ 4g, Radix Scrophulariae 8g ~ 12g, Flos Lonicerae 28g ~ 32g, Herba Patriniae 13g ~ 17g, Semen Coicis 13g ~ 17g and Radix Glycyrrhizae 8g ~ 12g.

Most preferably, in described gargarism, the weight of each crude drug is respectively Herba Melastomatis dodecandri 10g, Radix Acanthopanacis Trifoliati 10g, Folium Symplocoris Caudatae 3g, Herba monochasmatis 15g, Rhizoma Coptidis 30g, Radix Achyranthis Bidentatae 15g, Flos Eriocauli 10g, Du's Cortex Moutan 15g, Radix Paeoniae Alba 15g, Radix et Rhizoma Rhei Franzenbachii 20g, achillea millefolium 10g, Herba Asteris Ageratoidis 10g, Herba Cistanches 15g, Rhizoma Cimicifugae 10g, Radix Angelicae Dahuricae 20g, Fructus Mume 3g, Radix Scrophulariae 10g, Flos Lonicerae 30g, Herba Patriniae 15g, Semen Coicis 15g and Radix Glycyrrhizae 10g.

Present invention also offers the preparation method of above-mentioned gargarism, it comprises:

The first step, by Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Rhizoma Coptidis, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Flos Lonicerae, Herba Patriniae and Semen Coicis, is ground into fine powder respectively, mix by above-mentioned weight portion, adding relative to mixture quality 3 ~ 5 times of determining alcohols is that 70% alcohol heating reflux extracts 1 ~ 3 time, each 1 ~ 2 hour, merge extractive liquid, filter, decompression filtrate recycling ethanol, concentrated removing ethanol, obtains and gets dry extract, be ground into powder, cross 20 mesh sieves;

Second step, crude drug under remainder, is ground into fine powder respectively, mix by above-mentioned weight portion, add the water of mixture 1 ~ 3 times amount obtained relative to this step, heating extraction 2 times, extracts 30 ~ 45 minutes at every turn, 2 extracting solution are merged and leaves standstill, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves;

3rd step, the powder mixing first step and second step obtained, adds the deionized water of 8 ~ 12 times relative to mixture quality, obtains gargarism, conventional sterilant, bottling.

Each crude drug pharmacology is as follows:

Herba Melastomatis dodecandri: be the root of Genus Melastoma L. of Melastomataceae Herba Melastomatis Dodecandri, bitter in the mouth, micro-sweet, property is put down, return liver, lung, spleen channel, have promoting blood circulation and hemostasis, effect of eliminating damp, detoxifying, cures mainly and stimulates the menstrual flow, difficult labour, puerperal abdonimal pain, retention of placenta, metrorrhagia, leucorrhea, cough, spits blood, dysentery, jaundice, stranguria with blood, rheumatalgia, toothache, hernia, the cards such as traumatic injury.

Radix Acanthopanacis Trifoliati: bitter in the mouth, pungent, cool in nature, have heat-clearing and toxic substances removing, expelling wind and removing dampness, effect of relaxing muscles and tendons to promote blood circulation, cures mainly cold, fever, pharyngalgia, headache, and cough chest pain, has loose bowels, dysentery, hypochondriac pain, jaundice, stranguria caused by urinary stone, leukorrhagia, rheumatic arthralgia, waist and leg ache, the cards such as traumatic injury.

Folium Symplocoris Caudatae: be the leaf of vitriol platymiscium mountain, Symplocaceae mountain vitriol, sour in the mouth, puckery, micro-sweet, property is put down, and have heat-clearing and toxic substances removing, the therapeutic method to keep the adverse QI flowing downwards, effect of hemostasis, cures mainly chronic dysentery, wind-fire acute conjunctivitis, tonsillitis, otitis media, cough, vomiting, hemoptysis, the card such as to have blood in stool.

Herba monochasmatis: bitter in the mouth, cool in nature, for cough, spits blood, bloody dysentery, leukorrhagia, gingivitis, mastitis, furuncle and phyma.

Rhizoma Coptidis: bitter in the mouth, cold in nature, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, have effect of heat-clearing and toxic substances removing, eliminating fire and detoxication, parasite killing, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle, external treatment eczema, eczema, auditory meatus such as to be suppurated at the card.

Radix Achyranthis Bidentatae: bitter in the mouth, sweet, sour, property is put down, and returns liver, kidney channel, has the cards such as eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, drink blood is descending, cures mainly amenorrhea, dysmenorrhea, soreness of waist and knee joint, muscles and bones is unable, stranguria, edema, headache, dizzy, toothache, aphtha, the cards such as haematemesis.

Flos Eriocauli: acrid in the mouth, sweet, property is put down, and returns liver, stomach warp, has the effect of wind-dispelling heat-dissipating, improving acuity of vision and removing nebula, for cards such as conjunctival congestion and swelling pain, the many tear of photophobia, headache due to pathogenic wind-heat, toothache.

Du's Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel, has the effect of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, for the card such as fever due to yin deficiency, the acute appendicitis of damp and hot knot poison, depressed blood stasis, xerostomia, deep red tongue of excessive noxious heat; And liver-fire conjunctival congestion and swelling pain, stomach-fire gingiva pain.

The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature, enter liver, spleen channel, there is nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, and dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior card.

Radix et Rhizoma Rhei Franzenbachii: latin name Radix et Rhizome Rhei Franzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.

Achillea millefolium: acrid in the mouth; Bitter; Property flat temperature, there is wind-expelling pain-stopping; Effect of promoting blood circulation and detoxication, cures mainly cold, fever; Wind syndrome of head pain; Toothache; Rheumatic arthralgia; Blood stasis amenorrhea; Abdominal part mass in the abdomen; Traumatic injury; Venom; The cards such as carbuncle sore tumefacting virus.

Herba Asteris Ageratoidis: bitter in the mouth, pungent, cool in nature, have heat-clearing and toxic substances removing, the effect of the removing heat from blood that eliminates the phlegm, cures mainly cold, fever, tonsillitis, bronchitis, hepatitis, enteritis, pyretic stranguria, carbuncle furunculosis, the cards such as snake bite and insect sting.

Herba Cistanches: be the fleshy stem of Orobanchaceae Cistanche Hoffmgg. et Link plants Herba Cistanches and Cistanche Tubulosa, latin name herba cistanches is sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, have kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, deficiency of body fluid after being ill the card such as constipation.

Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has and deliver rash, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, the cards such as uterine prolapse.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Fructus Mume: bitter in the mouth, acid, puckery, warm in nature, enters liver, lung, spleen, large intestine channel, has and astringe the lung, astringing intestine to stop diarrhea, hemostasis, the effect of promoting the production of body fluid, be used for the treatment of chronic dysentery more than, damp-heat dysentery, have blood in stool, hematuria, the card such as snowslide.

Radix Scrophulariae: sweet in the mouth, hardship, salty, cold nature, returns lung, stomach, kidney channel, have clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing supports effect of kidney, cure mainly pathogenic warmth to join the army, cave in pericardium, maculae caused by violent heat pathogen, and consumption of YIN caused by febrile disease, crimson tongue excessive thirst, Tianjin hinder the cards such as constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.

Flos Lonicerae: latin name lonicerae japonicae flos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved.

Herba Patriniae: acrid in the mouth, hardship, cold nature, returns liver, stomach, large intestine channel, has heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, effect of stasis-dispelling and pain-killing, and for acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, breast abdomen pain, puerperal abdonimal pain, the cards such as dysmenorrhea.

Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.Have the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, suffer from diarrhoea in loose stool, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.

Radix Glycyrrhizae: property is put down, sweet in the mouth, enters 12 warps, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription, for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness, ulcer sores, laryngopharynx swelling and pain, asthma and cough, is in harmonious proportion some drugs strong.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 gargarism

By Herba Melastomatis dodecandri 10g, Radix Acanthopanacis Trifoliati 10g, Folium Symplocoris Caudatae 3g, Rhizoma Coptidis 30g, Du's Cortex Moutan 15g, Radix Paeoniae Alba 15g, Radix et Rhizoma Rhei Franzenbachii 20g, achillea millefolium 10g, Rhizoma Cimicifugae 10g, Radix Angelicae Dahuricae 20g, Fructus Mume 3g, Flos Lonicerae 30g, Herba Patriniae 15g, Semen Coicis 15g is ground into fine powder respectively, mixes by above-mentioned weight portion, and adding 850g determining alcohol is that 70% alcohol heating reflux extracts 3 times, each 2 hours, merge extractive liquid, filters, decompression filtrate recycling ethanol, concentrated removing ethanol, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, get Herba monochasmatis 15g, Radix Achyranthis Bidentatae 15g, Flos Eriocauli 10g, Herba Asteris Ageratoidis 10g, Herba Cistanches 15g, Radix Scrophulariae 10g and Radix Glycyrrhizae 10g is ground into fine powder respectively, mixes by above-mentioned weight portion, adds the water of 2kg, heating extraction 2 times, 2 extracting solution are merged and leave standstill by each extraction 45 minutes, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, by the powder mixing obtained above, add the deionized water of 10 times relative to mixture quality, obtain gargarism, conventional sterilant, bottling.

The toxicity test of medicine

Acute toxicity test:

Test method: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Gargarism prepared by embodiments of the invention 1 is concentrated into 8g crude drug/ml, gavage, gavage volume is 5ml/kg (namely unit dosage form is 40g crude drug/kg), matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage gargarism LD of the present invention ₅₀> 40g crude drug/kg, every day, maximum dosage-feeding was 75g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.1g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 750 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.

Cumulative toxicity test:

Test method: select 20 healthy mices, female, each 10 of hero, with the gargarism of the embodiment of the present invention 1 for object, dose design is first phase in every 5 days, and each issue dosage is respectively 0.10LD ₅₀, 0.2LD ₅₀, 0.3LD ₅₀, 0.4LD ₅₀, 0.5LD ₅₀, the LD of female, the male mice of this sample ₅₀be 6000m part/k part BW (five dosage is 600,1200,1800,2400,3000m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.It can thus be appreciated that gargarism of the present invention, Long-term taking medicine does not have cumulative toxicity.

Embodiment 2 gargarism

By Herba Melastomatis dodecandri 8g, Radix Acanthopanacis Trifoliati 8g, Folium Symplocoris Caudatae 2g, Rhizoma Coptidis 28g, Du's Cortex Moutan 13g, Radix Paeoniae Alba 13g, Radix et Rhizoma Rhei Franzenbachii 18g, achillea millefolium 8g, Rhizoma Cimicifugae 8g, Radix Angelicae Dahuricae 18g, Fructus Mume 2g, Flos Lonicerae 28g, Herba Patriniae 13g, Semen Coicis 13g is ground into fine powder respectively, mixes by above-mentioned weight portion, and adding 800g determining alcohol is that 70% alcohol heating reflux extracts 3 times, each 2 hours, merge extractive liquid, filters, decompression filtrate recycling ethanol, concentrated removing ethanol, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, get Herba monochasmatis 13g, Radix Achyranthis Bidentatae 13g, Flos Eriocauli 8g, Herba Asteris Ageratoidis 8g, Herba Cistanches 13g, Radix Scrophulariae 8g and Radix Glycyrrhizae 8g is ground into fine powder respectively, mixes by above-mentioned weight portion, adds the water of 1.8kg, heating extraction 2 times, 2 extracting solution are merged and leave standstill by each extraction 45 minutes, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, by the powder mixing obtained above, add the deionized water of 10 times relative to mixture quality, obtain gargarism, conventional sterilant, bottling.

Embodiment 3 gargarism

By Herba Melastomatis dodecandri 12g, Radix Acanthopanacis Trifoliati 12g, Folium Symplocoris Caudatae 4g, Rhizoma Coptidis 32g, Du's Cortex Moutan 17g, Radix Paeoniae Alba 17g, Radix et Rhizoma Rhei Franzenbachii 22g, achillea millefolium 12g, Rhizoma Cimicifugae 12g, Radix Angelicae Dahuricae 22g, Fructus Mume 4g, Flos Lonicerae 32g, Herba Patriniae 17g, Semen Coicis 17g is ground into fine powder respectively, mixes by above-mentioned weight portion, and adding 850g determining alcohol is that 70% alcohol heating reflux extracts 3 times, each 2 hours, merge extractive liquid, filters, decompression filtrate recycling ethanol, concentrated removing ethanol, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, get Herba monochasmatis 17g, Radix Achyranthis Bidentatae 17g, Flos Eriocauli 12g, Herba Asteris Ageratoidis 12g, Herba Cistanches 17g, Radix Scrophulariae 12g and Radix Glycyrrhizae 12g is ground into fine powder respectively, mixes by above-mentioned weight portion, adds the water of 2kg, heating extraction 2 times, 2 extracting solution are merged and leave standstill by each extraction 45 minutes, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves, by the powder mixing obtained above, add the deionized water of 10 times relative to mixture quality, obtain gargarism, conventional sterilant, bottling.

Embodiment 4 clinical data

Clinical data

Case selection: outpatient service selects patients with periodontitis 180 example as object of study.Periodontitis diagnostic criteria is with reference to " reference standards of periodontal disease diagnosis and treatment ".

Inclusive criteria: meet periodontitis diagnostic criteria, without periodontic endodontic lesion or needs are pulled out except wisdom teeth trouble tooth person;

Without the general disease of tool impact; Non-smoking; Within nearly three months, take history without periodontal disease therapeutic history and antibiotic.

Exclusion standard: therapy discontinued or the person that do not take Chinese medicine continuously for some reason; Person lost to follow-up.

Research method

Experiment grouping: 180 examples are randomized into 2 groups, each 110 examples of experimental group, matched group 70 example.

Matched group: adopt the conventional topical therapeutic of doctor trained in Western medicine, comprises oral hygiene and instructs, scaling on gum, subgingival debridement and root planing, blending etc., respectively at before treatment, treat latter 1 month time gather and record each clinical index.

Experimental group: matched group regular western medicine topical therapeutic adopts gargarism to gargle every day simultaneously, and every day 4 ~ 6 times, each 300ml, taking continuously 1 month is a course for the treatment of.

Tooth clinical indices suffered from record: plaque index (PLI), sulcular bleeding index (SBI), attachment loss (AL), Movable degree (MD), and B0P, PD take statistics Epidemiological Analysis.

Statistical method: measurement data adopts Spss16.0 software kit to carry out statistical analysis.

Criterion of therapeutical effect: effective: medication is after 4 weeks, and depth of pocket reduces to some extent, plaque index reduces more than 1.0, and sulcular bleeding index reduces to some extent, and attachment level changes or constant; The transference cure such as gingival hemorrhage, pain, swelling, red and swollen or abscess disappears, and depth of pocket obviously improves; Effective: local application is after 4 weeks, depth of pocket slightly reduces or unchanged, and plaque index reduces more than 0.5, and sulcular bleeding index slightly reduces, gingival hemorrhage, pain, and the symptoms such as swelling obviously alleviate, and red and swollen or abscess reduces, and depth of pocket is not improved; Invalid: local application is after 4 weeks, and depth of pocket slightly reduces or increase or sulcular bleeding index are without reducing or increasing on the contrary on the contrary, and odontoseisis does not alleviate or increases the weight of on the contrary, and above-mentioned clinical symptoms is not improved.Total effective rate=(effective+effectively)/total number of cases × 100%.

Result

Before and after treatment, 2 groups of indices changes, the results are shown in Table 1.

Indices change before and after the treatment of 2 groups, table 1

Time

Group

PLI

SBI

PD(mm)

AL(mm)

MD(mm)

Before treatment

Experimental group

2.2±0.2

1.9±0.3

5.1±0.3

4.9±0.2

0.9±0.1

Matched group

2.3±0.5

1.8±0.2

5.0±0.2

4.8±0.3

0.8±0.1

Claims (5)

1. be used for the treatment of a gargarism for chronic periodontitis, it is characterized in that: crude drug comprises Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Herba monochasmatis, Rhizoma Coptidis, Radix Achyranthis Bidentatae, Flos Eriocauli, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Herba Asteris Ageratoidis, Herba Cistanches, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Radix Scrophulariae, Flos Lonicerae, Herba Patriniae, Semen Coicis and Radix Glycyrrhizae.

2. gargarism as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Herba Melastomatis dodecandri 5g ~ 15g, Radix Acanthopanacis Trifoliati 5g ~ 15g, Folium Symplocoris Caudatae 1g ~ 5g, Herba monochasmatis 10g ~ 20g, Rhizoma Coptidis 25g ~ 35g, Radix Achyranthis Bidentatae 10g ~ 20g, Flos Eriocauli 5g ~ 15g, Du's Cortex Moutan 10g ~ 20g, Radix Paeoniae Alba 10g ~ 20g, Radix et Rhizoma Rhei Franzenbachii 15g ~ 25g, achillea millefolium 5g ~ 15g, Herba Asteris Ageratoidis 5g ~ 15g, Herba Cistanches 10g ~ 20g, Rhizoma Cimicifugae 5g ~ 15g, Radix Angelicae Dahuricae 15g ~ 25g, Fructus Mume 1g ~ 5g, Radix Scrophulariae 5g ~ 15g, Flos Lonicerae 25g ~ 35g, Herba Patriniae 10g ~ 20g, Semen Coicis 10g ~ 20g and Radix Glycyrrhizae 5g ~ 15g.

3. gargarism as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Herba Melastomatis dodecandri 8g ~ 12g, Radix Acanthopanacis Trifoliati 8g ~ 12g, Folium Symplocoris Caudatae 2g ~ 4g, Herba monochasmatis 13g ~ 17g, Rhizoma Coptidis 28g ~ 32g, Radix Achyranthis Bidentatae 13g ~ 17g, Flos Eriocauli 8g ~ 12g, Du's Cortex Moutan 13g ~ 17g, Radix Paeoniae Alba 13g ~ 17g, Radix et Rhizoma Rhei Franzenbachii 18g ~ 22g, achillea millefolium 8g ~ 12g, Herba Asteris Ageratoidis 8g ~ 12g, Herba Cistanches 13g ~ 17g, Rhizoma Cimicifugae 8g ~ 12g, Radix Angelicae Dahuricae 18g ~ 22g, Fructus Mume 2g ~ 4g, Radix Scrophulariae 8g ~ 12g, Flos Lonicerae 28g ~ 32g, Herba Patriniae 13g ~ 17g, Semen Coicis 13g ~ 17g and Radix Glycyrrhizae 8g ~ 12g.

4. the gargarism as described in claims 1 to 3, is characterized in that: the weight of each crude drug is respectively Herba Melastomatis dodecandri 10g, Radix Acanthopanacis Trifoliati 10g, Folium Symplocoris Caudatae 3g, Herba monochasmatis 15g, Rhizoma Coptidis 30g, Radix Achyranthis Bidentatae 15g, Flos Eriocauli 10g, Du's Cortex Moutan 15g, Radix Paeoniae Alba 15g, Radix et Rhizoma Rhei Franzenbachii 20g, achillea millefolium 10g, Herba Asteris Ageratoidis 10g, Herba Cistanches 15g, Rhizoma Cimicifugae 10g, Radix Angelicae Dahuricae 20g, Fructus Mume 3g, Radix Scrophulariae 10g, Flos Lonicerae 30g, Herba Patriniae 15g, Semen Coicis 15g and Radix Glycyrrhizae 10g.

5. the preparation method of gargarism described in Claims 1-4, is characterized in that, comprising:

The first step, by Herba Melastomatis dodecandri, Radix Acanthopanacis Trifoliati, Folium Symplocoris Caudatae, Rhizoma Coptidis, Du's Cortex Moutan, the Radix Paeoniae Alba, Radix et Rhizoma Rhei Franzenbachii, achillea millefolium, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Fructus Mume, Flos Lonicerae, Herba Patriniae and Semen Coicis, is ground into fine powder respectively, mix by above-mentioned weight portion, adding relative to mixture quality 3 ~ 5 times of determining alcohols is that 70% alcohol heating reflux extracts 1 ~ 3 time, each 1 ~ 2 hour, merge extractive liquid, filter, decompression filtrate recycling ethanol, concentrated removing ethanol, obtains and gets dry extract, be ground into powder, cross 20 mesh sieves;

Second step, crude drug under remainder, is ground into fine powder respectively, mix by above-mentioned weight portion, add the water of mixture 1 ~ 3 times amount obtained relative to this step, heating extraction 2 times, extracts 30 ~ 45 minutes at every turn, 2 extracting solution are merged and leaves standstill, filter, concentrated except anhydrating, obtain and get dry extract, be ground into powder, cross 20 mesh sieves;

3rd step, the powder mixing first step and second step obtained, adds the deionized water of 8 ~ 12 times relative to mixture quality, obtains gargarism, conventional sterilant, bottling.