CN107648166A - Natural nano toothpaste - Google Patents
Natural nano toothpaste Download PDFInfo
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- CN107648166A CN107648166A CN201711219267.XA CN201711219267A CN107648166A CN 107648166 A CN107648166 A CN 107648166A CN 201711219267 A CN201711219267 A CN 201711219267A CN 107648166 A CN107648166 A CN 107648166A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of natural nano toothpaste, is to belong to modern Chinese herbal medicine cosmetics high-tech nanometer toothpaste produced in series preparation technique field.Cleaned the teeth by Asiatic plantain Chinese gall shield tooth, the tasty and refreshing sterilization of hairyvein agrimony Ligusticum wallichii detumescence toxin expelling, nutmeg pot marigold spends clear protecting teeth anti-caries, Asian puccoon sophora flower anti-inflammation hemostasis preventing tumor nano-emulsion toothpaste to form except halitosis, madder turmeric fragrance decompose tartar, radix scutellariae golden cypress dental calculus preventing periodontosis, chrysanthemum beer.The present invention with particle diameter 30-100nm natural plants nano-particle small molecule, by brushing teeth the nano-particle in toothpaste, it is dispersed in periodontal, reach and play peculiar drug effect, drug molecule is introduced directly into containing the intracellular of lesion, taken in through lysosome, directly acts on intracellular pathogen, reach direct sterilization, anti-inflammatory anti-caries, control infection, clear tooth, clean the teeth, protect tooth, detumescence toxin expelling, anticancer, cleaning Buccodental health, disease-prevention health health.
Description
Technical field：
The invention discloses a kind of natural nano toothpaste, is to belong to modern Chinese herbal medicine cosmetics high-tech nanometer toothpaste produced in series to match somebody with somebody
Technical field processed.
Background technology：
Toothpaste is a kind of complicated mixture, and it is a kind of suspended substance being scattered in silty abrasive in colloidality gel.It is made
It is divided into cream, tubulation and filling three processes processed as process, wherein cream processed is the critical process for making toothpaste.According to colloidal sol preparation method
Difference, the manufacture craft of toothpaste are divided into two kinds of wet method colloidal sol cream and dry method colloidal sol paste manufacture process.Generally use both at home and abroad at present
Wet method colloidal sol paste manufacture process method.
Tooth is the organ of mastication of human body, still has the function of assisting pronunciation.In addition, tooth is to keeping the attractive in appearance of face
Play an important roll.There are two secondary teeth in all one's life of people, and a first long pair is deciduous teeth, afterwards a long secondary title permanent teeth.Deciduous teeth totally 20,
I.e. upper lower jaw, each 5 of left and right sides, have 2 deciduous incisor tooths, 1 deciduous cuspid and 2 deciduous molars per side.Permanent teeth 28-32, i.e., up and down
Each 7-8 of jaw, left and right sides, there are 2 incisors, 1 canine tooth, 2 bicuspids and 2-3 to grind one's teeth in sleep per side.Deciduous teeth are typically in 6-12
Come off during year, the substitute is this replacement process of permanent teeth, deciduous teeth and permanent teeth, commonly referred to as grow permanent teeth.Tooth is mainly
Tooth body and periodontium two parts composition, therefore, the toothpaste preparation production to take care of one's teeth is particularly important, and cleaning oral cavity is defended
It is raw, take care of one's teeth, be the major issue of health of people.
The content of the invention：
It is an object of the invention to provide a kind of natural nano toothpaste.
The technology of the present invention solve scheme be：
1st, a kind of natural nano toothpaste, it is characterized in that：Asiatic plantain Chinese gall shield tooth cleans the teeth nano-emulsion toothpaste, by following masses
Proportioning composition %
Hydroxyethyl cellulose 0.5-1.5；Polyvinylpyrrolidone 0.2-0.6；
Glycerine 5-15；Herba Plantaginis extract 0.4-1.2；
Fennel oil-like extracts 1-3；Nutgall extractive 1-3；
Chalk 20-60；Cream jasmin france 0.2-0.6；
Lauryl sodium sulfate 0.3-0.6；Caryophyllus oil 0.5-1.5；
Orange oil 0.2-0.6；Purified water adds to 100%；
Preparation method：By hydroxyethyl cellulose, polyvinylpyrrolidone and glycerine it is dispersed after, add purified water fully dissolve
Into colloidal solution.After placing certain time, fennel oil extract, nutgall extractive, chalk, cream jasmin france, Asiatic plantain are added
Extract, caryophyllus oil, lauryl sodium sulfate, orange oil, it is kneaded into cream.
This product has the effect such as convergence, hemostasis, antibacterial, effective in cure to thrush, stomatitis, gingivitis etc..And can protect tooth,
Clean the teeth, and have cloves smell, it is suitable for people of all ages.
Asiatic plantain is the drying herb of plantago plant Chinese herbaceous peony or ordinary building.Main component：Seed lymphatic temperament containing volume, and
Containing plantenolic acid, choline, adenine, butanedioic acid, vitamin B1, fat oil, protein, resin etc..With promoting diuresis for stranguria, heat-clearing
The effect of improving eyesight.There is the work such as diuresis, sterilization, antigout, lowering blood pressure and blood fat, antiatherosclerosis, antidiarrheal, kobadrin
With.This product has inhibitory action to various bacteria and dermatophyte, also has resist inflammation on repercussive function to scytitis.Herba Plantaginis extract
It can be made into toothpaste, facial mask etc..
Chinese gall is formed for the melaphis chinensis Baker parasitism on Anacardiaceae plant cigarette skin water, potanin sumac or redpunjab sumac root blade back
Insect gall.It is divided into " tripe times " and " angle times " by profile is of different sizes.Containing Gallotannin.Separately contain gallic acid, fat, resin and wax
Matter.The effect of with fall fire of astringing the lung, arrest sweating hemostasis.There is the effect such as convergence, antidiarrheal, hemostasis, antibacterial.Chinese nutgall, which is made, to be contained
Agent, toothpaste are gargled, it is effective in cure to thrush, stomatitis, gingivitis.
2nd, a kind of natural nano toothpaste, it is characterized in that：The hairyvein agrimony Ligusticum wallichii detumescence toxin expelling nano-emulsion toothpaste, is matched somebody with somebody by following masses
Than forming %
Carboxymethyl cellulose 0.2-0.6；Polyvinyl alcohol 0.4-1.2；
Glycerine 5-15；Rhizoma Chuanxiong extract 0.1-0.3；
Chalk 10-30；Cream jasmin france 0.2-0.6；
Calcium monohydrogen phosphate 10-30；Herba Agrimoniae extract 0.2-0.6；
Saccharin 0.1-0.3；Caryophyllus oil 0.2-0.6；
Lauryl sodium sulfate 0.5-1.5；Purified water adds to 100%；
Preparation method：By carboxymethyl cellulose, polyvinyl alcohol and glycerine it is dispersed after, add purified water be fully dissolved into colloid
Solution.After placing certain time, caryophyllus oil, lauryl sodium sulfate, saccharin, calcium monohydrogen phosphate, Herba Agrimoniae extract, the root of Dahurain angelica are added
Extract, Rhizoma Chuanxiong extract, chalk, cream jasmin france, are kneaded into cream,.This product can anti-inflammation and sterilization, clean the teeth, protect tooth, analgesia,
Except halitosis, and fragrant odour.
Hairyvein agrimony is the herb of rosaceous plant hairyvein agrimony.Main component：Herb is containing agrimonine, agrimonolide, tan
Matter, sterol, organic acid, saponin(e etc..The effect of sore, desinsection being treated with astringing to arrest bleeding, inducing diaphoresis.There are anti-inflammatory, hemostasis, the disease-resistant micro- life of original
The effect such as thing, antitumor, analgesic.
3rd, a kind of natural nano toothpaste, it is characterized in that：The tasty and refreshing sterilization of nutmeg pot marigold removes halitosis nano-emulsion toothpaste,
% is formed by following quality proportioning
Chlorophyll 1-3；Honegsukle flower P.E 0.3-0.9；
Hydroxyethyl cellulose 0.3-0.9；Borneol 0.1-0.3；
Carboxymethyl cellulose 0.5-1.5；Glycerine 5-15；
Mace oil 0.5-1.5；Methyl p-hydroxybenzoate 0.1-0.3；
Propylparaben 0.1-0.3；Lauryl sodium sulfate 0.3-0.9；
Calcium carbonate 10-30；Saccharin 0.1-0.3；
Attar of rose 0.5-1.5；Purified water adds to 100%；
Preparation method：By carboxymethyl cellulose, hydroxyethyl cellulose and glycerine it is dispersed after, add purified water be fully dissolved into
Colloidal solution.After placing certain time, mace oil, Honegsukle flower P.E, chlorophyll, methyl p-hydroxybenzoate, right is added
Nipasol, lauryl sodium sulfate, calcium carbonate, saccharin, attar of rose, are kneaded into cream,.
This product have cleaning tooth, it is tasty and refreshing, sterilize and go halitosis etc. to act on, and in treatment gum abscess, bleeding and rush
The effect of entering gingiva tissue growth, analgesia shield tooth.
Nutmeg is the myristic dry mature kernal of myristicaceae plant.Also known as flesh fruit, semen myristicae.Main component：Containing waving
Hair oil mace oil, contain the terpenes such as α-firpene and α-amphene constituents, myristicin, agalloch eaglewood oleyl alcohol etc. in oily.With puckery intestines
Antidiarrheal, the effect of middle benefit gas promoting the circulation of qi.Contained volatile oil, the secretion and gastrointestinal peristalsis that gastric juice can be promoted on a small quantity, largely then there is suppression to make
With.Terpenes constituents in volatile oil have inhibitory action to bacterium and fungi.Mace oil coordinates with attar of rose is made shield tooth
Toothpaste, have cleaning, it is tasty and refreshing, sterilization etc. effect.
Marigold is the herb and flower of the small pot marigold of feverfew.Also known as pot marigold.Main component：Herb contains isoquercitrin
Glycosides, rutin sophorin, narcissin；Flower is containing essential oil, amaroid, resin, natural gum etc..The effect of with clearing away heat to stop bleeding.Have antiviral, anti-prominent
Change and anastalsis.The extract solution of marigold has the effect of anti-inflammatory anti-itch, moisturizing, beauty.For making toothpaste, can not only rise
To the effect such as the cleaning the teeth of general toothpaste, tasty and refreshing, sterilization, and treatment gum abscess, bleeding and promote gingiva tissue growth,
Removing halitosis etc. also has positive role.
4th, a kind of natural nano toothpaste, it is characterized in that：The madder turmeric fragrance decomposes tartar nano-emulsion toothpaste, by following
Quality proportioning forms %
Hydroxyethyl cellulose 0.3-0.9；Glycerine 5-15；
Madder extract 1-3；Radix Gentianae extract 1-3；
Carnation oil 0.5-1.5；Calcium carbonate 5-15；
Kaolin 2-6；Turmeric P.E 1-3；
Flavoring rose essence 0.2-0.6；Magnesium carbonate 5-15；
Radix Trichosanthis extract 1-3；Purified water adds to 100%；
Preparation method：Added after hydroxyethyl cellulose is mixed with glycerine in purified water, be heated to 80 DEG C of dissolvings, stir,
Madder extract, Turmeric P.E, Radix Trichosanthis extract, Radix Gentianae extract, carnation oil, carbonic acid are added when being cooled to 45 DEG C
Calcium, magnesium sulfate, kaolin, essence, are kneaded into cream, this product fragrant odour, tasty and refreshing, and have anti-inflammatory, sterilization, hemostasis and decompose tartar
Effect.Other this product also has the effect for protecting tooth.
Madder is the drying root and rhizome of madder wort madder.Main component：Containing purple alizarin, alizarin, psedopurpurin, madder
Careless pigment etc..The effect of with cooling blood and hemostasis, promoting blood circulation.There are hemostasis, increasing leukocyte, antibechic, eliminating the phlegm, resisting pathogenic microbes
Deng effect.Madder extract solution has the function that hemostasis, resisting pathogenic microbes.For making toothpaste type cosmetics, have it is tasty and refreshing, disappear
The effect of scorching, sterilization, hemostasis.
Turmeric is the dry rhizome of zingiberaceous plant turmeric.Main component：Containing volatile oil 4.5% -6%, contain turmeric in volatile oil
Ketone, zingerene, phellandrene, 1,8-Cineole, sabinene, borneol, dehydroturmerone etc., also containing curcumin, arabinose, fruit
Sugar, glucose, fat oil, starch, oxalates etc..With blood-breaking, it is inducing meastruation to relieve menalgia the effect of.Resist myocardial ischemia.It is anti-dynamic
Pulse atherosclerosis, reducing blood lipid, cholagogic, liver protection, anti-inflammatory, antibacterial etc. act on.The uranidin of turmeric extraction can be used as the day of cosmetics
Right pigment.Be set forth in turmeric has antibacterial action, there is different degrees of inhibitory action to a variety of dermatophytes.
Root of Chinese trichosanthes contains trichosanthin and several amino acids needed by human, has antibacterial, antitumor, anti-inflammation detumescence row
The effect of purulence.Root of Chinese trichosanthes, turmeric with anti-inflammation is antiviral with having, act synergistically, antibacterial effect it is more peculiar.
5th, a kind of natural nano toothpaste, it is characterized in that：The radix scutellariae golden cypress prevents and treats calculus dentalis periodontosis nano-emulsion toothpaste, presses
Following masses proportioning composition %
Coconut oil alkylolamides 1.5-4.5；Glycerine 15-45；
Astragalus Root P.E 1-3；Flos Chrysanthemi extract 0.2-0.6；
Carboxymethyl cellulose 0.3-0.9；Propane diols 5-15；
Baical Skullcap root P.E 0.6-1.8；Turmeric P.E 0.5-1.5；
Calcium monohydrogen phosphate 20-60；Lauryl sodium sulfate 0.2-0.6；
Saccharin 0.1-0.3；Cream jasmin france 0.2-0.6；
Dextranase 0.1-0.3；Menthol 0.2-0.6；
Purified water adds to 100%；
Preparation method：Purified water is added after coconut oil alkylolamides, carboxymethyl cellulose, propane diols are mixed with glycerine, is uniformly divided
After dissipating, stir, add Astragalus Root P.E, Flos Chrysanthemi extract, Baical Skullcap root P.E, Turmeric P.E, calcium monohydrogen phosphate, dodecane
Base sodium sulphate, menthol, saccharin, cream jasmin france, dextranase, are kneaded into cream,.This product has anti-inflammation and sterilization, antibacterial, clean
The effect of tooth, anti-caries and pre- dental calculus preventing.Prevent and treat periodontosis, and the good merchantable brand for thering is peppermint faint scent to be cleaning teeth.
Radix scutellariae is the dry root of labiate radix scutellariae.Main component：Root containing baicalein, scutelloside, wogonoside and
Neobaicalein, also β-sitosterol, benzoic acid etc..The effect of with heat-clearing and damp-drying drug, purging intense heat and detonicating.There are anti-inflammatory, resistance state anti-
Should, resisting pathogenic microbes, antipyretic, decompression, diuresis, calmness, cholagogic, reducing blood lipid, antiatherosclerosis, antithrombotic etc. act on.
Radix scutellariae has very wide antimicrobial spectrum, therefore the cosmetics containing Baical Skullcap root P.E have treatment oral inflammation and anaphylactia well
Effect.
The Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus.Main component：Containing glycoside, glucuronic acid,
Lymphatic temperament, amino acid, bitter principle, choline, glycine betaine, folic acid, trace element etc..Disappear with invigorating qi for consolidating superficies, promoting pus discharge and tissue regeneration, Li Shui
The effect of swollen.There is the effect such as promoting blood circulation and removing blood stasis, antibacterial, antiviral, expansion blood vessel, regulation immunologic function, improvement hematopoiesis function.The Radix Astragali
Contain several amino acids, glycine betaine and the essential trace elements of the human body.
6th, a kind of natural nano toothpaste, it is characterized in that：The chrysanthemum beer spends clear protecting teeth anti-caries nano-emulsion toothpaste, presses
Following masses proportioning composition %
Hydroxyethyl cellulose 0.4-1.2；Lupulus extract 0.2-0.6；
Orange oil 0.2-0.6；Caryophyllus oil 1-2；
Carboxymethyl cellulose 0.3-0.9；Polyvinylpyrrolidone 0.1-0.3；
Glycerine 10-30；Chalk 15-45；
Mint extract 0.2-0.6；Chrysanthemum extract 1-3；
Honegsukle flower P.E 0.2-0.6；Calcium phosphate 1-3；
Lauryl sodium sulfate 0.2-0.6；Saccharin 0.1-0.3；
Essence 0.2-0.6；Purified water adds to 100%；
Preparation method：By hydroxyethyl cellulose, carboxymethyl cellulose, polyvinylpyrrolidone and glycerine it is dispersed after, add
Purified water is fully dissolved into colloidal solution.After placing certain time, add purified water and fully resolve into colloidal solution, then add
Lupulus extract, chalk, mint extract, chrysanthemum extract, Honegsukle flower P.E, saccharin, orange oil, dodecyl sulphate
Sodium, calcium phosphate, caryophyllus oil, essence, preservative, are kneaded into cream,.This product can prevent and treat periodontosis, clean protecting teeth, and fragrance is refreshing
Mouthful.Commonly using the incidence of disease that can reduce periodontium and carious tooth.
Chrysanthemum is the dry capitulum of feverfew chrysanthemum.Also known as Bo chrysanthemum, chu chrysanthemum, tribute chrysanthemum, FLOS CHRYSANTHEMI ALBA from Haizhou of China, Huai Chrysanthemi etc..It is main
Want composition：Containing volatile oil 0.13% -0.2%, contain borneol, borneol acetic acid esters, chrysanthanone etc. in oil.Another glycosides containing chrysanthemum, flavonoids, ammonia
Base acid, adenine, choline, stachydrine, vitamin A sample material, vitamin A sample material, vitamin B1 etc..With wind-dispelling heat-dissipating,
The effect of clearing liver and improving vision, be clearing heat and detoxicating.There are antipyretic, suppression capillary permeability, resisting pathogenic microbes, hypotensive, expansion hat
Shape artery, calmness, reducing blood lipid, antiatherosclerosis, the effect such as enhancing body resistance against diseases, antipyretic.Chrysanthemum extract liquid has
Antibacterial, the effect of anti-inflammatory, for making skin care, shield tooth cosmetics.
Hops is the female inflorescence of Cannabaceae plant hops.Also known as hops.Main component：Contain hop oil, hops tree
Fat, polyatomic phenol material, protein, fat, cellulose, trace element etc..The effect of calming the nerves with stomach strengthening and digestion promoting, diuresis.Have
Antibacterial, calmness, estrogen-like action.Hop resin has sterilization, anti-inflammatory, antibacterial, antiviral, improvement blood circulation, norcholesterol,
Suppress the multiple efficacies such as platelet aggregation.
7th, a kind of natural nano toothpaste, it is characterized in that：The Asian puccoon sophora flower anti-inflammation hemostasis preventing tumor nano-emulsion toothpaste,
% is formed by following quality proportioning
Carboxymethyl cellulose 0.4-1.2；Propane diols 7-21；
Radix Arnebiae extract 2-6；Baical Skullcap root P.E 0.5-1.5；
Saccharin 0.1-0.3；Calcium carbonate 15-45；
Lauryl sodium sulfate 0.2-0.6；Vanillic aldehyde 0.1-0.3；
Attar of rose 0.2-0.6；Flos Sophorae extract 1.5-4.5；
Carrot seed carbonic acid soaks juice 0.2-0.6；Orange oil 0.2-0.6；
Propylparaben 0.1-0.3；Essence 0.1-0.3；
Purified water adds to 100%；
Preparation method：By carboxymethyl cellulose and propane diols it is dispersed after, add purified water be fully dissolved into colloidal solution.Put
After putting certain time, Radix Arnebiae extract, Baical Skullcap root P.E, saccharin, calcium carbonate, vanillic aldehyde, lauryl sodium sulfate, sophora flower are added
Extract, carrot seed carbonic acid leaching juice, orange oil, propylparaben, essence, are kneaded into cream,.This product have anti-inflammatory,
Antibacterial, preventing decayed tooth function.
Asian puccoon is the root and rhizome of comfrey, Asian puccoon or lithospermum euchromum Royle.Containing alkannin, Acetylshikonin, isobutyryl
Alkannin, IVS etc..The effect of with cooling and activating blood, removing toxic substances promoting eruption.There is antipyretic, anti-inflammatory, resisting pathogenic microbes, strong
The heart, promoting eruption, antifertility, antitumor etc. act on.The main component alkannin of Asian puccoon, it is that the needle-like for extracting to obtain from Asian puccoon root is brilliant
Body, aubergine, odorless, security is good, nontoxic, no sensitization, non-stimulated to skin, and chemical stability is good, also restrains, disappears
Scorching, antibacterial functions.
Sophora flower is the drying flower and alabastrum of legume Chinese scholartree.Containing rutin sophorin（Rutin）, still A prime containing sophora flower, tannin, grease,
Volatile oil, carbohydrate etc..The effect of with cool blood, hemostasis, hypotensive, spasmolysis, antiulcer, anti-inflammatory, hypotensive, antimycotic etc. are made
With.
Natural plants Asiatic plantain, Chinese gall in plant nanometer toothpaste of the present invention, fennel oil-like extracts, hairyvein agrimony, river
Rhizome of chuanxiong, pot marigold, madder, felwort, root of Chinese trichosanthes, turmeric, radix scutellariae, the Radix Astragali, camomile, hops, chrysanthemum, peppermint, Asian puccoon, sophora flower,
Hu Luozi, its particle diameter form in 30-100nm natural material and the auxiliary material of making.By natural nutrition material disintegrating into 60 mesh
Coarse powder, add 8 times of water, suspension be made, mixed in colloid mill and carry out micronization processes, refinement liquid is placed in homogenizer again
Mixing refinement is carried out, nanosizing crushing is carried out, natural nutrition material nano liquid of the particle diameter in 30-100nm is made.It is a kind of
Nanoscale crushed material or nanosizing micro emulsion containing natural component, this nano-emulsion toothpaste maintain the whole of natural nutrition material
Nutritional ingredient, so the nutritional ingredient in toothpaste is more complete.This nano-emulsion have good permeance property, seepage velocity compared with
It hurry up, good absorbing effect.With nanometer fine powder of the scale dimension applications as 0.1-100nm in toothpaste, in bio-pharmaceutical preparation research
With play the role of in application it is identical important.This belongs to the content and category of microsphere formulation, is that microballoon, nanosphere, group disperse
The extension and development of technology and β-cyclodextrin inclusion technique.Its application in bio-pharmaceutical preparation be mainly medicine with
（Or）Nanoparticle is made in carrier, and adds certain targeting material, medicine is reached site of action quickly in vivo, fully hair
Wave its effect.Nano-particle possesses certain ultra micro yardstick in toothpaste of the present invention, between 30-100nm, when brushing teeth by it
Superfine nano micromolecule comes out from toothpaste is bonded at gum, around root of the tooth and makes these nano-particles in " uniform " point
Cloth, peculiar drug effect is played, while there is the Peculiar function for killing cancer cell without hindering normal cell, reduce hepatic macrophages pair
The phagocytosis of medicine, the combination for improving target-oriented drug, hindering hematoglobin protein composition and phosphatide etc., extend circulation time in vivo etc.
Play an important roll, reach to brush teeth and cure the disease, and medicine can be introduced directly into containing the intracellular of pathogen, taken in through lysosome, directly
Connect and act on intracellular pathogen.As intracellular for controlling and being not easily accessible treating the antibiotic of infection, be into
Enter, its holdup time in the cell is also very of short duration.Nano micromolecule in toothpaste of the present invention can be by target-oriented drug
Import in infection cell, medicine constantly slowly release in the cell, so as to increase the therapeutic action to intracellular infection.
With reference to embodiment, the present invention is further described
Specific implementation method：
Embodiment 1：A kind of natural nano toothpaste, it is characterized in that：Asiatic plantain Chinese gall shield tooth cleans the teeth nanometer toothpaste, by following
Quality proportioning forms %
Hydroxyethyl cellulose 0.5-1.5；Polyvinylpyrrolidone 0.2-0.6；
Glycerine 5-15；Herba Plantaginis extract 0.4-1.2；
Fennel oil-like extracts 1-3；Nutgall extractive 1-3；
Chalk 20-60；Cream jasmin france 0.2-0.6；
Lauryl sodium sulfate 0.3-0.6；Caryophyllus oil 0.5-1.5；
Orange oil 0.2-0.6；Purified water adds to 100%；
Embodiment 2：A kind of natural nano toothpaste, it is characterized in that：The hairyvein agrimony Ligusticum wallichii detumescence toxin expelling nanometer toothpaste, by following matter
Amount proportioning composition %
Carboxymethyl cellulose 0.2-0.6；Polyvinyl alcohol 0.4-1.2；
Glycerine 5-15；Rhizoma Chuanxiong extract 0.1-0.3；
Chalk 10-30；Cream jasmin france 0.2-0.6；
Calcium monohydrogen phosphate 10-30；Herba Agrimoniae extract 0.2-0.6；
Saccharin 0.1-0.3；Caryophyllus oil 0.2-0.6；
Lauryl sodium sulfate 0.5-1.5；Purified water adds to 100%；
Embodiment 3：A kind of natural nano toothpaste, it is characterized in that：The tasty and refreshing sterilization of nutmeg pot marigold removes halitosis nanometer toothpaste,
% is formed by following quality proportioning
Chlorophyll 1-3；Honegsukle flower P.E 0.3-0.9；
Hydroxyethyl cellulose 0.3-0.9；Borneol 0.1-0.3；
Carboxymethyl cellulose 0.5-1.5；Glycerine 5-15；
Mace oil 0.5-1.5；Methyl p-hydroxybenzoate 0.1-0.3；
Propylparaben 0.1-0.3；Lauryl sodium sulfate 0.3-0.9；
Calcium carbonate 10-30；Saccharin 0.1-0.3；
Attar of rose 0.5-1.5；Purified water adds to 100%；
Embodiment 4：A kind of natural nano toothpaste, it is characterized in that：The madder turmeric fragrance decomposes tartar nanometer toothpaste, by following
Quality proportioning forms %
Hydroxyethyl cellulose 0.3-0.9；Glycerine 5-15；
Madder extract 1-3；Radix Gentianae extract 1-3；
Carnation oil 0.5-1.5；Calcium carbonate 5-15；
Kaolin 2-6；Turmeric P.E 1-3；
Flavoring rose essence 0.2-0.6；Magnesium carbonate 5-15；
Radix Trichosanthis extract 1-3；Purified water adds to 100%；
Embodiment 5：A kind of natural nano toothpaste, it is characterized in that：The radix scutellariae golden cypress prevents and treats calculus dentalis periodontosis nanometer toothpaste, presses
Following masses proportioning composition %
Coconut oil alkylolamides 1.5-4.5；Glycerine 15-45；
Astragalus Root P.E 1-3；Flos Chrysanthemi extract 0.2-0.6；
Carboxymethyl cellulose 0.3-0.9；Propane diols 5-15；
Baical Skullcap root P.E 0.6-1.8；Turmeric P.E 0.5-1.5；
Calcium monohydrogen phosphate 20-60；Lauryl sodium sulfate 0.2-0.6；
Saccharin 0.1-0.3；Cream jasmin france 0.2-0.6；
Dextranase 0.1-0.3；Menthol 0.2-0.6；
Purified water adds to 100%；
Embodiment 6：A kind of natural nano toothpaste, it is characterized in that：The chrysanthemum beer spends clear protecting teeth caries preventing nano tooth paste, presses
Following masses proportioning composition %
Hydroxyethyl cellulose 0.4-1.2；Lupulus extract 0.2-0.6；
Orange oil 0.2-0.6；Caryophyllus oil 1-2；
Carboxymethyl cellulose 0.3-0.9；Polyvinylpyrrolidone 0.1-0.3；
Glycerine 10-30；Chalk 15-45；
Mint extract 0.2-0.6；Chrysanthemum extract 1-3；
Honegsukle flower P.E 0.2-0.6；Calcium phosphate 1-3；
Lauryl sodium sulfate 0.2-0.6；Saccharin 0.1-0.3；
Essence 0.2-0.6；Purified water adds to 100%；
Embodiment 7：A kind of natural nano toothpaste, it is characterized in that：The Asian puccoon sophora flower anti-inflammation hemostasis preventing tumor nanometer toothpaste,
% is formed by following quality proportioning
Carboxymethyl cellulose 0.4-1.2；Propane diols 7-21；
Radix Arnebiae extract 2-6；Baical Skullcap root P.E 0.5-1.5；
Saccharin 0.1-0.3；Calcium carbonate 15-45；
Lauryl sodium sulfate 0.2-0.6；Vanillic aldehyde 0.1-0.3；
Attar of rose 0.2-0.6；Flos Sophorae extract 1.5-4.5；
Carrot seed carbonic acid soaks juice 0.2-0.6；Orange oil 0.2-0.6；
Propylparaben 0.1-0.3；Essence 0.1-0.3；
Purified water adds to 100%.
Claims (7)
1. a kind of natural nano toothpaste, it is characterized in that：Asiatic plantain Chinese gall shield tooth cleans the teeth nanometer toothpaste, matches somebody with somebody by following masses
Than forming %
Hydroxyethyl cellulose 0.5-1.5；Polyvinylpyrrolidone 0.2-0.6；
Glycerine 5-15；Herba Plantaginis extract 0.4-1.2；
Fennel oil-like extracts 1-3；Nutgall extractive 1-3；
Chalk 20-60；Cream jasmin france 0.2-0.6；
Lauryl sodium sulfate 0.3-0.6；Caryophyllus oil 0.5-1.5；
Orange oil 0.2-0.6；Purified water adds to 100%.
2. a kind of natural nano toothpaste, it is characterized in that：The hairyvein agrimony Ligusticum wallichii detumescence toxin expelling nanometer toothpaste, by following quality proportioning
Form %
Carboxymethyl cellulose 0.2-0.6；Polyvinyl alcohol 0.4-1.2；
Glycerine 5-15；Rhizoma Chuanxiong extract 0.1-0.3；
Chalk 10-30；Cream jasmin france 0.2-0.6；
Calcium monohydrogen phosphate 10-30；Herba Agrimoniae extract 0.2-0.6；
Saccharin 0.1-0.3；Caryophyllus oil 0.2-0.6；
Lauryl sodium sulfate 0.5-1.5；Purified water adds to 100%.
3. a kind of natural nano toothpaste, it is characterized in that：The tasty and refreshing sterilization of nutmeg pot marigold removes halitosis nanometer toothpaste, by following
Quality proportioning forms %
Chlorophyll 1-3；Honegsukle flower P.E 0.3-0.9；
Hydroxyethyl cellulose 0.3-0.9；Borneol 0.1-0.3；
Carboxymethyl cellulose 0.5-1.5；Glycerine 5-15；
Mace oil 0.5-1.5；Methyl p-hydroxybenzoate 0.1-0.3；
Propylparaben 0.1-0.3；Lauryl sodium sulfate 0.3-0.9；
Calcium carbonate 10-30；Saccharin 0.1-0.3；
Attar of rose 0.5-1.5；Purified water adds to 100%.
4. a kind of natural nano toothpaste, it is characterized in that：The madder turmeric fragrance decomposes tartar nanometer toothpaste, matches somebody with somebody by following masses
Than forming %
Hydroxyethyl cellulose 0.3-0.9；Glycerine 5-15；
Madder extract 1-3；Radix Gentianae extract 1-3；
Carnation oil 0.5-1.5；Calcium carbonate 5-15；
Kaolin 2-6；Turmeric P.E 1-3；
Flavoring rose essence 0.2-0.6；Magnesium carbonate 5-15；
Radix Trichosanthis extract 1-3；Purified water adds to 100%.
5. a kind of natural nano toothpaste, it is characterized in that：The radix scutellariae golden cypress prevents and treats calculus dentalis periodontosis nanometer toothpaste, by following matter
Amount proportioning composition %
Coconut oil alkylolamides 1.5-4.5；Glycerine 15-45；
Astragalus Root P.E 1-3；Flos Chrysanthemi extract 0.2-0.6；
Carboxymethyl cellulose 0.3-0.9；Propane diols 5-15；
Baical Skullcap root P.E 0.6-1.8；Turmeric P.E 0.5-1.5；
Calcium monohydrogen phosphate 20-60；Lauryl sodium sulfate 0.2-0.6；
Saccharin 0.1-0.3；Cream jasmin france 0.2-0.6；
Dextranase 0.1-0.3；Menthol 0.2-0.6；
Purified water adds to 100%.
6. a kind of natural nano toothpaste, it is characterized in that：The chrysanthemum beer spends clear protecting teeth caries preventing nano tooth paste, by following matter
Amount proportioning composition %
Hydroxyethyl cellulose 0.4-1.2；Lupulus extract 0.2-0.6；
Orange oil 0.2-0.6；Caryophyllus oil 1-2；
Carboxymethyl cellulose 0.3-0.9；Polyvinylpyrrolidone 0.1-0.3；
Glycerine 10-30；Chalk 15-45；
Mint extract 0.2-0.6；Chrysanthemum extract 1-3；
Honegsukle flower P.E 0.2-0.6；Calcium phosphate 1-3；
Lauryl sodium sulfate 0.2-0.6；Saccharin 0.1-0.3；
Essence 0.2-0.6；Purified water adds to 100%.
7. a kind of natural nano toothpaste, it is characterized in that：The Asian puccoon sophora flower anti-inflammation hemostasis preventing tumor nanometer toothpaste, by following
Quality proportioning forms %
Carboxymethyl cellulose 0.4-1.2；Propane diols 7-21；
Radix Arnebiae extract 2-6；Baical Skullcap root P.E 0.5-1.5；
Saccharin 0.1-0.3；Calcium carbonate 15-45；
Lauryl sodium sulfate 0.2-0.6；Vanillic aldehyde 0.1-0.3；
Attar of rose 0.2-0.6；Flos Sophorae extract 1.5-4.5；
Carrot seed carbonic acid soaks juice 0.2-0.6；Orange oil 0.2-0.6；
Propylparaben 0.1-0.3；Essence 0.1-0.3；
Purified water adds to 100%.
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| CN201711219267.XA CN107648166A (en) | 2017-11-28 | 2017-11-28 | Natural nano toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711219267.XA CN107648166A (en) | 2017-11-28 | 2017-11-28 | Natural nano toothpaste |
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| Publication Number | Publication Date |
|---|---|
| CN107648166A true CN107648166A (en) | 2018-02-02 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078875A (en) * | 2018-02-27 | 2018-05-29 | 贵安新区瑞诚生物工程有限公司 | The preparation method and its production system of a kind of small molecule Chinese medicine antibacterial toothpaste and skin care item |
| CN108403543A (en) * | 2018-03-22 | 2018-08-17 | 湖南三五二环保科技有限公司 | A kind of prevention acute toothache Chinese herbal toothpaste |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
| CN111603415A (en) * | 2019-02-22 | 2020-09-01 | 好维股份有限公司 | Oral care compositions comprising hops extract and uses |
| CN113230178A (en) * | 2021-06-11 | 2021-08-10 | 焦作大安日用化工有限公司 | Toothpaste containing Huai chrysanthemum extract and preparation method thereof |
| WO2023113637A1 (en) * | 2021-11-24 | 2023-06-22 | "Скайлаб Aг" | Synergistic remineralizing combination |
-
2017
- 2017-11-28 CN CN201711219267.XA patent/CN107648166A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078875A (en) * | 2018-02-27 | 2018-05-29 | 贵安新区瑞诚生物工程有限公司 | The preparation method and its production system of a kind of small molecule Chinese medicine antibacterial toothpaste and skin care item |
| CN108403543A (en) * | 2018-03-22 | 2018-08-17 | 湖南三五二环保科技有限公司 | A kind of prevention acute toothache Chinese herbal toothpaste |
| CN111603415A (en) * | 2019-02-22 | 2020-09-01 | 好维股份有限公司 | Oral care compositions comprising hops extract and uses |
| CN111603415B (en) * | 2019-02-22 | 2023-12-19 | 好维股份有限公司 | Oral care compositions comprising hops extract and uses thereof |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
| CN113230178A (en) * | 2021-06-11 | 2021-08-10 | 焦作大安日用化工有限公司 | Toothpaste containing Huai chrysanthemum extract and preparation method thereof |
| WO2023113637A1 (en) * | 2021-11-24 | 2023-06-22 | "Скайлаб Aг" | Synergistic remineralizing combination |
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Application publication date: 20180202 |