CN111388610A - Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis - Google Patents
Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis, which is prepared from the following raw materials in parts by weight: 5-7 parts of ligusticum wallichii, 6-9 parts of lalang grass rhizome, 4-6 parts of hairyvein agrimony and 2-4 parts of astragalus membranaceus. The traditional Chinese medicine composition has accurate compatibility of medicines and synergistic interaction, can prevent symptoms such as red and swollen gums, bleeding and gingival atrophy and the like, and effectively treats gingivitis. Can be used for preparing oral products such as toothpaste, mouthwash and the like, and has good market prospect.
Description
Technical Field
The invention particularly relates to a traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis.
Background
Gingiva is one of periodontal tissues (gingiva, periodontal ligament, alveolar bone, cementum), directly exposed to the oral cavity, and visible under direct vision, and is composed of keratinized epithelium and connective tissue, covering the alveolar bone and tooth root. Gum disease is a lesion localized to the gingival tissue, of which chronic gingivitis, also known as marginal gingivitis, simple gingivitis, is the most common disease in plaque gingivitis, belonging to the "gingivitis related only to plaque". The inflammation of gum is mainly located free gum and gingival papilla, and children of 3 ~ 5 years old can take place, and prevalence and severity increase gradually along with the age growth, reach the peak to the puberty. Gingivitis is slightly more prevalent in men than women in children. Developing countries and regions are higher than economically developed countries.
Mention of "Puji Fang, Upper sore door": deficiency of qi and blood, failure of wiping and clearing, wind pathogen attacking the deficient teeth, which leads to weak muscle and blood, contra-fleshy teeth and contraction of teeth, and gradual diffusion and exposure without adhering to the roots of teeth. "indicate that when the human body is deficient in both qi and blood, the yangming meridians of hand and foot can not discharge essence slightly to the gums, and the gums are not nourished, so the gums are pale; if wind pathogen is further infected, the gum flesh will shrink into the liquid. This suggests that insufficient qi and blood may lead to periodontal disease.
At present, many researches on medicaments for treating periodontal diseases are reported, wherein the Chinese medicinal composition is the key point of the research as a medicament type with high safety, but no reports related to the Chinese medicinal composition with less medicinal flavor, low cost and remarkable effect exist.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis, which is prepared from the following raw materials in parts by weight:
5-7 parts of ligusticum wallichii, 6-9 parts of lalang grass rhizome, 4-6 parts of hairyvein agrimony and 2-4 parts of astragalus membranaceus.
Further, the feed additive is prepared from the following raw materials in parts by weight:
5 parts of ligusticum wallichii, 6 parts of rhizoma imperatae, 4 parts of hairyvein agrimony and 3 parts of astragalus membranaceus.
Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically or cosmetically acceptable auxiliary materials.
Still further, the formulation is an oral care formulation.
Further, the oral care product formulation is a powder, a toothpaste or a mouthwash.
The invention also provides a preparation method of the traditional Chinese medicine composition, and the preparation method of the extract comprises the following steps:
1) weighing the raw materials according to the proportion;
2) mixing and crushing the raw materials, adding water for decocting twice, adding 9-10 times of water for one-time decoction, soaking for 40-50 min, keeping slight boiling for 50-60 min after boiling, and filtering; adding 7-8 times of water into the twice decoction, boiling, keeping slightly boiling for 40-50 min, filtering, combining the two filtrates, and concentrating the filtrate at 60-65 ℃ under reduced pressure until the relative density is 1.20-1.30 to obtain an extract;
3) and (3) drying the extract obtained in the step 2) at 60 +/-5 ℃ in vacuum until the surface is crisp and hard without wet powder, and carrying out superfine grinding to obtain the powder.
The invention also provides a preparation method of the traditional Chinese medicine composition, and the preparation of the powder comprises the following steps:
a, weighing raw material medicines according to a ratio;
b, mixing and crushing the raw material medicines, and sieving the raw material medicines by a 100-mesh sieve to obtain medicinal powder; mixing the following components in a mass ratio of 3: 2, mixing and grinding the borneol and the mentholum uniformly to obtain ice powder;
c mixing the medicinal powder and the ice powder in a ratio of 18: 5, and mixing uniformly to obtain the product.
The invention also provides a preparation method of the traditional Chinese medicine composition, wherein the mouthwash is prepared by dissolving the prepared extract in an aqueous solution according to the mass percent of 8%;
the water solution is also dissolved with 5.2 percent of glycerin, 3.1 percent of sorbitol, 0.5 percent of PEG-40 hydrogenated castor oil, 2.0 percent of tea extract, 0.5 percent of trichlorogalactose, 1.2 percent of propylene glycol, 0.3 percent of sodium citrate, 0.1 percent of lactic acid, 2.0 percent of xylitol, 0.5 percent of menthol, 0.1 percent of glyceryl caprylate, 0.4 percent of saccharin sodium, 0.1 percent of EDTA disodium, 0.02 percent of essence and 0.1 percent of methylparaben.
Further, the tea extract is a green tea extract.
The invention finally provides application of the traditional Chinese medicine composition in preparing a medicine for preventing gingival atrophy.
The invention finally provides application of the traditional Chinese medicine composition in preparation of a medicine for treating gingivitis.
The ligusticum wallichii is derived from dried rhizome of an umbelliferae plant ligusticum wallichii L iguusticum chuanxiong Hort, is pungent and warm, enters liver, gallbladder and pericardium channels, is commonly used for activating blood and promoting qi circulation, dispelling wind and relieving pain, is pungent, warm, fragrant and dry, can be moved without guarding, can be scattered, can ascend to the vertex, can enter blood system, can descend to blood sea, has wide effects of activating blood and removing stasis, can treat symptoms such as headache, rheumatism and the like, has antibacterial and antiviral effects, and can inhibit inflammatory reaction and treat infectious diseases.
The lalang grass rhizome is dried rhizome of Imperatoylindrica Beauv.var.major (Nees) C.E.Hubb. of Gramineae, and has effects of cooling blood, stopping bleeding, clearing heat, and promoting urination. Can be used for treating hematemesis due to blood heat, epistaxis, hematuria, fever polydipsia, jaundice, edema, stranguria caused by heat, and pain; edema due to acute nephritis. The cogongrass rhizome can enhance the hemostatic effect by influencing the blood coagulation system and the platelet aggregation, and also has the broad-spectrum antibacterial, anti-inflammatory and analgesic effects.
The agrimony is the dry overground part of Agrimonia pilosa L edeb which is a rosaceous plant, and has the effects of astringing to stop bleeding, preventing malaria, stopping dysentery and detoxifying.
The radix astragali is dried root of Astragalus membranaceus (Fisch.) Bge. of Leguminosae family or Astragalus membranaceus (Fisch.) Bge. of Hsiao. The main effects are invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, inducing diuresis, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed wound. Modern pharmacology indicates that astragalus can promote the generation of body antibodies, enhance the immune function of the body, improve the activity of natural killer cells and enhance the phagocytic function of phagocytic cells, and can be used for chronic infectious diseases.
In the pharmaceutical composition, the ligusticum wallichii and the lalang grass rhizome are monarch drugs, the agrimony is a ministerial drug, the astragalus membranaceus is an adjuvant drug, the ligusticum wallichii activates blood and promotes qi, the vertex can be reached, and the blood can be reached to the sea; the cogongrass rhizome can cool blood and stop bleeding, can enhance the hemostatic effect by influencing the blood coagulation system and the platelet aggregation, and also has the functions of broad-spectrum bacteriostasis, anti-inflammation and analgesia. Herba et Gemma Agrimoniae has effects of astringing, stopping bleeding, resisting bacteria, and relieving pain; radix astragali is used together with radix astragali for invigorating qi, consolidating superficial resistance, expelling toxin, expelling pus, and promoting granulation. The medicines are used together to play the efficacies of benefiting qi and nourishing blood, strengthening and nourishing teeth and gum, stopping bleeding and inhibiting bacteria, can effectively treat gingivitis, and prevent symptoms of gingival swelling, bleeding, gingival atrophy and the like.
Clinical tests prove that: the Chinese medicinal composition has accurate compatibility of medicines and synergistic interaction, and can effectively treat gingivitis and prevent symptoms of red and swollen gums, bleeding, gingival atrophy and the like. Can be used for preparing oral products such as toothpaste, mouthwash and the like, and has good market prospect.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of the medicament of the invention
The formula is as follows: 5 parts of ligusticum wallichii, 6 parts of rhizoma imperatae, 4 parts of hairyvein agrimony and 3 parts of astragalus membranaceus.
The preparation method comprises the following steps:
(1) weighing the raw material medicines according to the proportion of the formula;
(2) mixing and pulverizing the raw materials, placing in a decocting pot, decocting in water for 2 times, adding 9 times of water for one time, soaking for 40min, decocting, boiling, keeping slightly boiling for 50min, and filtering; adding 7 times of water into the second decoction, boiling, keeping slightly boiling for 40min, filtering, and mixing the two filtrates;
(3) concentrating the filtrate at 65 ℃ under reduced pressure to obtain an extract with the density of 1.20-1.30;
(4) vacuum drying the extract at 60 + -5 deg.C until the surface is crisp and hard and no wet powder is present, and collecting the material;
(5) and carrying out superfine grinding on the collected materials to obtain the medicinal composition active ingredient extract I.
Example 2 preparation of the inventive Agents
The formula is as follows: 7g of ligusticum wallichii, 9g of rhizoma imperatae, 6g of hairyvein agrimony and 4g of astragalus.
The preparation method comprises the following steps:
(1) weighing the raw material medicines according to the proportion of the formula;
(2) mixing and pulverizing the raw materials, placing in a decocting pot, decocting in water for 2 times, adding 10 times of water for one time, soaking for 50min, decocting, boiling, maintaining slight boiling for 60min, and filtering; adding 8 times of water into the second decoction, boiling, keeping slightly boiling for 45min, filtering, and combining the two filtrates;
(3) concentrating the filtrate at 60-65 ℃ under reduced pressure to obtain an extract with the density of 1.20-1.30;
(4) vacuum drying the extract at 60 + -5 deg.C until the surface is crisp and hard and no wet powder is present, and collecting the material;
(5) and carrying out superfine grinding on the collected materials to obtain the medicinal composition active ingredient extract II.
Example 3 preparation of the inventive Agents
The formula is as follows: 6g of ligusticum wallichii, 8g of rhizoma imperatae, 5g of hairyvein agrimony and 2g of astragalus.
The preparation method comprises the following steps:
(1) weighing the raw material medicines according to the proportion of the formula;
(2) mixing and pulverizing the raw materials, placing in a decocting pot, decocting in water for 2 times, adding 10 times of water for one time, soaking for 50min, decocting, boiling, maintaining slight boiling for 60min, and filtering; adding 8 times of water into the second decoction, boiling, keeping slightly boiling for 45min, filtering, and combining the two filtrates;
(3) concentrating the filtrate at 60-65 ℃ under reduced pressure to obtain an extract with the density of 1.20-1.30;
(4) vacuum drying the extract at 60 + -5 deg.C until the surface is crisp and hard and no wet powder is present, and collecting the material;
(5) and carrying out superfine grinding on the collected materials to obtain the active ingredient extract III of the pharmaceutical composition.
Example 4 preparation of a powder of the invention for treating gingivitis
5g of ligusticum wallichii, 6g of rhizoma imperatae, 4g of hairyvein agrimony, 3g of astragalus mongholicus, 3g of borneol and 2g of menthol.
(1) Respectively carrying out superfine grinding on the medicinal materials, and then sieving the medicinal materials by a 100-mesh sieve;
(2) weighing rhizoma Ligustici Chuanxiong, lalang grass rhizome, herba et Gemma Agrimoniae, and radix astragali according to the formula, grinding in a mortar, and pouring out;
(3) grinding Borneolum Syntheticum and Mentholum in mortar, adding mixed powder of rhizoma Ligustici Chuanxiong, and grinding to uniform color.
Example 5 preparation of a mouthwash of the invention to prevent gingivitis
1) Taking the traditional Chinese medicine extract I prepared in the example 1, deionized water, glycerol, sorbitol, PEG-40 hydrogenated castor oil, tea extract, trichlorogalactose, propylene glycol, sodium citrate, lactic acid, xylitol, menthol, glyceryl caprylate, saccharin sodium, EDTA disodium, essence and methyl hydroxybenzoate;
2) mixing and dissolving the raw materials to prepare a solution with the following mass percent:
75.88% of deionized water, 5.2% of glycerol, 3.1% of sorbitol, 0.5% of PEG-40 hydrogenated castor oil, 2.0% of green tea extract, 8.0% of traditional Chinese medicine extract I, 0.5% of trichlorogalactose, 1.2% of propylene glycol, 0.3% of sodium citrate, 0.1% of lactic acid, 2.0% of xylitol, 0.5% of menthol, 0.1% of caprylic acid glyceride, 0.4% of saccharin sodium, 0.1% of disodium EDTA, 0.02% of essence and 0.1% of methylparaben.
Filling the obtained collutory liquid into a collutory packaging bag by adopting an aseptic tank.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1
1. Clinical data
102 patients with gingivitis who were treated by the department of stomatology of the university of traditional Chinese medicine in Chengdu, Sichuan province in 2018, 5 months to 2018, 11 months were selected. Wherein 43 men and 59 women are aged 16-50 years, and the average age is 31 years
1.1 inclusion criteria
① the stomatology department of the university of Chinese medicine Hospital in Chengdu was diagnosed with gingivitis.
② the study is informed by himself and his family members and signed a consent.
③ is between 16 and 50 years old.
④ has no other visceral diseases and no obvious secondary infection.
1.2 exclusion criteria
① with severe systemic disease or malignancy;
② those with mental illness unable to communicate properly;
③ those who have used antibiotics within 3 months before treatment;
④ the clinical data is not complete.
⑤ pregnant and lactating women;
⑥ allergic to the product of this test.
2. Method of treatment
The product is applied externally, and after cleaning, a proper amount of the extract I prepared in the example 1 is applied to the gum affected part. It is administered 3 times daily, 4-5 times daily for long term chronic or severe cases, and is not directly applied to eye, ear or skin injury (such as unhealed wound, infection, ulcer or erosive wound). One week is 1 course of treatment, and 1-3 courses of treatment are used.
3. Criteria for judging therapeutic effects
① recovering the gingival swelling and pain, stopping bleeding, and no recurrence for more than half a year;
② is effective in relieving gingival swelling and pain, and reducing bleeding frequency;
③ is not effective, and the gingival swelling and pain and gingival bleeding are not improved or even aggravated.
Total effective rate (cure + effective) cases/total cases × 100%.
4. Therapeutic results
| Recovery (case) | Effective (example) | Invalid (example) | Total effective rate | |
| Example 6 | 73 | 23 | 6 | 94.1％ |
The test results show that: after the product is used for 1 treatment course, the gum is red, swollen and painful, and the bleeding frequency is reduced; after 2-3 treatment courses, the redness, swelling and pain of the gum disappear, and bleeding stops.
In conclusion, the Chinese medicinal composition has accurate compatibility of medicines and synergistic effect, and can effectively treat gingivitis and prevent symptoms such as red and swollen gums, bleeding and the like. Can be used for preparing oral products such as toothpaste, mouthwash and the like, and has good market prospect.
Claims (11)
1. A traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis is characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
5-7 parts of ligusticum wallichii, 6-9 parts of lalang grass rhizome, 4-6 parts of hairyvein agrimony and 2-4 parts of astragalus membranaceus.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the traditional Chinese medicine is prepared from the following raw materials in parts by weight:
5 parts of ligusticum wallichii, 6 parts of rhizoma imperatae, 4 parts of hairyvein agrimony and 3 parts of astragalus membranaceus.
3. The traditional Chinese medicine composition according to claim 1 or 2, wherein: the preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding auxiliary materials acceptable in medicines or cosmetics.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein: the preparation is an oral care product preparation.
5. The traditional Chinese medicine composition according to claim 4, wherein: the oral care product preparation is powder, toothpaste or mouthwash.
6. A method for preparing the traditional Chinese medicine composition of claim 3, which is characterized by comprising the following steps: the preparation of the extract comprises the following steps:
1) weighing the raw material medicines according to the mixture ratio of claim 1;
2) mixing and crushing the raw materials, adding water for decocting twice, adding 9-10 times of water for one-time decoction, soaking for 40-50 min, keeping slight boiling for 50-60 min after boiling, and filtering; adding 7-8 times of water into the twice decoction, boiling, keeping slightly boiling for 40-50 min, filtering, combining the two filtrates, and concentrating the filtrate at 60-65 ℃ under reduced pressure until the relative density is 1.20-1.30 to obtain an extract;
3) and (3) drying the extract obtained in the step 2) at 60 +/-5 ℃ in vacuum until the surface is crisp and hard without wet powder, and carrying out superfine grinding to obtain the powder.
7. A method for preparing the traditional Chinese medicine composition of claim 5, which is characterized by comprising the following steps: the preparation of the powder comprises the following steps:
a, weighing raw material medicaments according to the mixture ratio of claim 1;
b, mixing and crushing the raw material medicines, and sieving the raw material medicines by a 100-mesh sieve to obtain medicinal powder; mixing the following components in a mass ratio of 3: 2, mixing and grinding the borneol and the mentholum uniformly to obtain ice powder;
c mixing the medicinal powder and the ice powder in a ratio of 18: 5, and mixing uniformly to obtain the product.
8. A method for preparing the traditional Chinese medicine composition of claim 5, which is characterized by comprising the following steps: the mouthwash is prepared by dissolving the extract prepared in the claim 6 in an aqueous solution with the mass percent of 8%;
the water solution is also dissolved with 5.2 percent of glycerin, 3.1 percent of sorbitol, 0.5 percent of PEG-40 hydrogenated castor oil, 2.0 percent of tea extract, 0.5 percent of trichlorogalactose, 1.2 percent of propylene glycol, 0.3 percent of sodium citrate, 0.1 percent of lactic acid, 2.0 percent of xylitol, 0.5 percent of menthol, 0.1 percent of glyceryl caprylate, 0.4 percent of saccharin sodium, 0.1 percent of EDTA disodium, 0.02 percent of essence and 0.1 percent of methylparaben.
9. The method of claim 8, wherein: the tea extract is a green tea extract.
10. Use of the Chinese medicinal composition of any one of claims 1 to 5 for the preparation of a medicament for preventing gingival atrophy.
11. Use of a Chinese medicinal composition according to any one of claims 1 to 5 in the preparation of a medicament for the treatment of gingivitis.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010276296.5A CN111388610A (en) | 2020-04-09 | 2020-04-09 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
| PCT/CN2020/120107 WO2021203648A1 (en) | 2020-04-09 | 2020-10-10 | Traditional chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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| CN202010276296.5A CN111388610A (en) | 2020-04-09 | 2020-04-09 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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| WO (1) | WO2021203648A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021203648A1 (en) * | 2020-04-09 | 2021-10-14 | 四川绿色本草科技发展有限公司 | Traditional chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114209638B (en) * | 2021-12-31 | 2023-07-14 | 广西养利农业投资开发有限公司 | Compound kuding tea traditional Chinese medicine composition for preparing toothpaste and compound kuding tea traditional Chinese medicine toothpaste |
| CN114832036A (en) * | 2022-05-13 | 2022-08-02 | 漳州无极药业有限公司 | Medicinal composition for treating gingivitis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510666A (en) * | 2013-12-21 | 2015-04-15 | 莫治玲 | Mouthwash for treating gingival bleeding |
| CN106692755A (en) * | 2017-01-03 | 2017-05-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition |
| CN107648166A (en) * | 2017-11-28 | 2018-02-02 | 南通蛇类治疗研究所 | Natural nano toothpaste |
| CN108186541A (en) * | 2018-03-19 | 2018-06-22 | 纳诺神蜂（福建）个人护理用品有限公司 | Multi-efficiency type mouthwash and preparation method thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101327274A (en) * | 2008-07-28 | 2008-12-24 | 郑际然 | Chinese medicine gargle for treating toothache |
| CN107375060A (en) * | 2017-07-12 | 2017-11-24 | 南通蛇类治疗研究所 | Both effectiveness plant toothpaste |
| CN108186441A (en) * | 2018-02-10 | 2018-06-22 | 广州市九科精细化工有限公司 | A kind of antianaphylactic compound herbal mouthwash of hemostasis and preparation method thereof |
| KR102636026B1 (en) * | 2018-06-05 | 2024-02-14 | 재단법인 경기도경제과학진흥원 | Composition for prevention or trreatment of dental disease comprising an extract of Thalictrum aquilegiifolium |
| CN111388610A (en) * | 2020-04-09 | 2020-07-10 | 四川绿色本草科技发展有限公司 | Traditional Chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510666A (en) * | 2013-12-21 | 2015-04-15 | 莫治玲 | Mouthwash for treating gingival bleeding |
| CN106692755A (en) * | 2017-01-03 | 2017-05-24 | 四川新绿色药业科技发展有限公司 | Traditional Chinese medicine composition with functions of stopping bleeding, eliminating inflammation and preventing bacteria and preparation method and application of traditional Chinese medicine composition |
| CN107648166A (en) * | 2017-11-28 | 2018-02-02 | 南通蛇类治疗研究所 | Natural nano toothpaste |
| CN108186541A (en) * | 2018-03-19 | 2018-06-22 | 纳诺神蜂（福建）个人护理用品有限公司 | Multi-efficiency type mouthwash and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 晨与鱼: "逛直播间被种草的心水好物！", 《HTTPS://WWW.XIAOHONGSHU.COM/DISCOVERY/ITEM/5E7AC1CF00000000010034DF》 * |
| 陈有才: "我的清新口气小心机 千方百剂来帮忙", 《HTTPS://WWW.XIAOHONGSHU.COM/DISCOVERY/ITEM/5E79F8DC0000000001001601》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021203648A1 (en) * | 2020-04-09 | 2021-10-14 | 四川绿色本草科技发展有限公司 | Traditional chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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