CN114832036A - Medicinal composition for treating gingivitis and preparation method thereof - Google Patents
Medicinal composition for treating gingivitis and preparation method thereof Download PDFInfo
- Publication number
- CN114832036A CN114832036A CN202210521290.9A CN202210521290A CN114832036A CN 114832036 A CN114832036 A CN 114832036A CN 202210521290 A CN202210521290 A CN 202210521290A CN 114832036 A CN114832036 A CN 114832036A
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- radix
- aconiti lateralis
- monkshood
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- 238000002360 preparation method Methods 0.000 title claims description 27
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- 239000010231 banlangen Substances 0.000 claims abstract description 12
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- 230000001737 promoting effect Effects 0.000 abstract description 4
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- 230000006022 acute inflammation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 230000000740 bleeding effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
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- 230000006020 chronic inflammation Effects 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
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- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
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- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Botany (AREA)
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Abstract
The invention relates to a pharmaceutical composition for treating gingivitis, which comprises monkshood, dandelion, honeysuckle, mint, isatis root, cortex moutan and mangnolia officinalis. The pharmaceutical composition of the invention is purely natural traditional Chinese medicine components, and has no side effect on human body; the honeysuckle, the dandelion and the mint in the traditional Chinese medicine extracting solution have the effects of diminishing inflammation, resisting bacteria, relieving sore throat, promoting the secretion of saliva or body fluid, removing peculiar smell and the like, have the functions of inhibiting bacteria, diminishing inflammation and detoxifying, and have obvious effect on gingivitis; radix Aconiti lateralis Preparata in the Chinese medicinal extractive solution has antiinflammatory and analgesic effects; the cortex moutan contains paeonol, the cortex magnoliae officinalis contains magnolol, and both the paeonol and the magnolol have good anti-inflammatory and antibacterial effects; the radix Isatidis has heat and toxic materials clearing away effect, and the extractive solution can effectively inhibit common cocci, typhoid fever and influenza bacillus, and can also improve immunity.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating gingivitis and a preparation method thereof.
Background
The soft tissue surrounding and covering around the teeth is called gingiva medically, acute and chronic inflammation occurring in the gingival tissue is called gingivitis, gingival bleeding is taken as a main characteristic, bleeding is easy to bleed when brushing teeth, sucking and chewing hard objects generally, the gingiva is bright red or purple red, swelling or softness, the surface is bright, calculus, soft scale and dental plaque are accumulated locally, the preferential gingival margin erosion is caused, a small amount of pus is discharged by squeezing the gingival margin, gingival papillary edema and gingival sulcus deepening can occur, and even gingival abscess is formed.
At present, most of various periodontal local medicament formulations are bacteriostatic and bactericidal preparations or certain biomembrane preparations which can only play a role in promoting regeneration of gingival tissues, but can cause dysbacteriosis and generate drug resistance and other adverse effects, so people expect a relatively ideal natural medicament which has the functions of resisting inflammation and inhibiting bacteria, regulating oral micro-ecological balance and promoting regeneration and repair of gingival tissues.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for treating gingivitis and a preparation method thereof.
A pharmaceutical composition for treating gingivitis comprises radix Aconiti lateralis Preparata, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 6-9 parts of monkshood, 20-25 parts of dandelion, 20-25 parts of honeysuckle, 20-25 parts of mint, 10-15 parts of isatis root, 15-20 parts of cortex moutan and mangnolia officinalis.
Further, the pharmaceutical composition further comprises: scutellariae radix, radix Ophiopogonis, flos Chrysanthemi, radix Paeoniae Rubra, radix asparagi, radix Angelicae Dahuricae and Saviae Miltiorrhizae radix.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 12-15 parts of scutellaria baicalensis, 5-9 parts of radix ophiopogonis, 8-12 parts of chrysanthemum, 5-8 parts of red paeony root, 5-8 parts of asparagus, 3-5 parts of angelica dahurica and 3-5 parts of salvia miltiorrhiza.
A pharmaceutical composition for treating gingivitis and a preparation method thereof comprise the following steps:
the method comprises the following steps: processing radix Aconiti lateralis, removing toxicity to obtain radix Aconiti lateralis, pulverizing radix Aconiti lateralis, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis;
step two: putting the powder of the aconite, the dandelion, the honeysuckle, the mint, the isatis root, the cortex moutan and the mangnolia officinalis into a reflux extractor, adding a certain proportion of ethanol for reflux extraction, combining the extracting solutions, standing the extracting solution, filtering to obtain filtrate, performing reduced pressure concentration by using a rotary evaporator to remove the ethanol, and concentrating the filtrate to 0.1-1 g/mL to obtain a traditional Chinese medicine extracting solution;
step three: making the Chinese medicinal extractive solution into various Chinese medicinal preparations.
The processing method of the monkshood comprises the following steps:
the method comprises the following steps: removing fibrous root from fresh radix Aconiti lateralis, cleaning, and sun drying to obtain dried radix Aconiti lateralis;
step two: soaking the dry monkshood in clean water, taking out when the monkshood is semi-transparent, placing the semi-transparent monkshood in a medicine tank, and spraying clean water every two hours until the monkshood is completely moistened;
step three: steaming the radix Aconiti lateralis in a steam tank until the fragrance overflows, stopping steaming, taking out the radix Aconiti lateralis, slicing, and oven drying to obtain radix Aconiti lateralis.
The Chinese medicinal preparation is toothpaste, oral care solution or decoction.
A toothpaste containing Chinese medicinal composition for treating gingivitis is prepared by mixing Chinese medicinal extractive solution, abrasive, wetting agent, binder and foaming agent, stirring, grinding, and vacuum degassing to obtain toothpaste.
A preparation method of oral care solution of a pharmaceutical composition for treating gingivitis comprises sequentially adding surfactant, xylitol, sorbitol, Chinese medicinal extractive solution, magnesium lithium silicate and bacteriostatic agent into deionized water, and mixing to obtain oral care solution.
A method for preparing decoction of medicinal composition for treating gingivitis comprises mixing the Chinese medicinal extractive solution with deionized water at equal ratio, and sterilizing to obtain decoction of medicinal composition.
The invention has the following advantages: the pharmaceutical composition of the invention is purely natural traditional Chinese medicine components, and has no side effect on human body; the honeysuckle, the dandelion and the mint in the traditional Chinese medicine extracting solution have the effects of diminishing inflammation, resisting bacteria, relieving sore throat, promoting the secretion of saliva or body fluid, removing peculiar smell and the like, have the functions of inhibiting bacteria, diminishing inflammation and detoxifying, and have obvious effect on gingivitis; radix Aconiti lateralis Preparata in the Chinese medicinal extractive solution has antiinflammatory and analgesic effects; the cortex moutan contains paeonol, the cortex magnoliae officinalis contains magnolol, and both the paeonol and the magnolol have good anti-inflammatory and antibacterial effects; the radix Isatidis has heat and toxic materials clearing away effect, and the extractive solution can effectively inhibit common coccus, typhoid bacillus and influenza bacillus, and improve immunity.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. The objectives and other advantages of the invention will be realized and attained by the structure particularly pointed out in the written description and claims hereof.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A pharmaceutical composition for treating gingivitis comprises radix Aconiti lateralis Preparata, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 6 parts of monkshood, 20 parts of dandelion, 20 parts of honeysuckle, 20 parts of mint, 10 parts of isatis root, 15 parts of cortex moutan and magnolia officinalis.
Further, the pharmaceutical composition further comprises: scutellariae radix, radix Ophiopogonis, flos Chrysanthemi, radix Paeoniae Rubra, radix asparagi, radix Angelicae Dahuricae and Saviae Miltiorrhizae radix.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 12 parts of scutellaria baicalensis, 5 parts of radix ophiopogonis, 8 parts of chrysanthemum, 5 parts of red paeony root, 5 parts of radix asparagi, 3 parts of angelica dahurica and 3 parts of salvia miltiorrhiza.
A pharmaceutical composition for treating gingivitis and a preparation method thereof comprise the following steps:
the method comprises the following steps: processing radix Aconiti lateralis, removing toxicity to obtain radix Aconiti lateralis, and pulverizing radix Aconiti lateralis, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis;
step two: putting the powder of the aconite, the dandelion, the honeysuckle, the mint, the isatis root, the cortex moutan and the mangnolia officinalis into a reflux extractor, adding a certain proportion of ethanol for reflux extraction, combining the extracting solutions, standing the extracting solution, filtering to obtain filtrate, performing reduced pressure concentration by using a rotary evaporator to remove the ethanol, and concentrating the filtrate to 0.1-1 g/mL to obtain a traditional Chinese medicine extracting solution;
step three: making the Chinese medicinal extractive solution into various Chinese medicinal preparations.
The processing method of the monkshood comprises the following steps:
the method comprises the following steps: removing fibrous root from fresh radix Aconiti lateralis, cleaning, and sun drying to obtain dried radix Aconiti lateralis;
step two: soaking the dry monkshood in purified water, taking out when the monkshood is semi-permeable, putting the semi-permeable monkshood into a medicine pool, and spraying purified water every two hours until the monkshood is completely moistened;
step three: steaming the radix Aconiti lateralis in a steam tank until the fragrance overflows, stopping steaming, taking out the radix Aconiti lateralis, slicing, and oven drying to obtain radix Aconiti lateralis.
The Chinese medicinal preparation is toothpaste, oral care solution or decoction.
A toothpaste containing Chinese medicinal composition for treating gingivitis is prepared by mixing Chinese medicinal extractive solution, abrasive, wetting agent, binder and foaming agent, stirring, grinding, and vacuum degassing to obtain toothpaste.
A preparation method of oral care solution of a pharmaceutical composition for treating gingivitis comprises sequentially adding surfactant, xylitol, sorbitol, Chinese medicinal extractive solution, magnesium lithium silicate and bacteriostatic agent into deionized water, and mixing to obtain oral care solution.
A method for preparing decoction of medicinal composition for treating gingivitis comprises mixing the Chinese medicinal extractive solution with deionized water at equal ratio, and sterilizing to obtain decoction of medicinal composition.
Example 2
A pharmaceutical composition for treating gingivitis comprises radix Aconiti lateralis Preparata, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 8 parts of monkshood, 22 parts of dandelion, 23 parts of honeysuckle, 21 parts of mint, 12 parts of isatis root, 18 parts of cortex moutan and magnolia officinalis.
Further, the pharmaceutical composition further comprises: scutellariae radix, radix Ophiopogonis, flos Chrysanthemi, radix Paeoniae Rubra, radix asparagi, radix Angelicae Dahuricae and Saviae Miltiorrhizae radix.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 13 parts of scutellaria baicalensis, 7 parts of radix ophiopogonis, 11 parts of chrysanthemum, 6 parts of red paeony root, 7 parts of radix asparagi, 4 parts of radix angelicae and 4 parts of salvia miltiorrhiza.
A pharmaceutical composition for treating gingivitis and a preparation method thereof comprise the following steps:
the method comprises the following steps: processing radix Aconiti lateralis, removing toxicity to obtain radix Aconiti lateralis, and pulverizing radix Aconiti lateralis, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis;
step two: putting the powder of the aconite, the dandelion, the honeysuckle, the mint, the isatis root, the cortex moutan and the mangnolia officinalis into a reflux extractor, adding a certain proportion of ethanol for reflux extraction, combining the extracting solutions, standing the extracting solution, filtering to obtain filtrate, performing reduced pressure concentration by using a rotary evaporator to remove the ethanol, and concentrating the filtrate to 0.1-1 g/mL to obtain a traditional Chinese medicine extracting solution;
step three: making the Chinese medicinal extractive solution into various Chinese medicinal preparations.
The processing method of the monkshood comprises the following steps:
the method comprises the following steps: removing fibrous root from fresh radix Aconiti lateralis, cleaning, and sun drying to obtain dried radix Aconiti lateralis;
step two: soaking the dry monkshood in purified water, taking out when the monkshood is semi-permeable, putting the semi-permeable monkshood into a medicine pool, and spraying purified water every two hours until the monkshood is completely moistened;
step three: steaming the radix Aconiti lateralis in a steam tank until the fragrance overflows, stopping steaming, taking out the radix Aconiti lateralis, slicing, and oven drying to obtain radix Aconiti lateralis.
The Chinese medicinal preparation is toothpaste, oral care solution or decoction.
A toothpaste containing Chinese medicinal composition for treating gingivitis is prepared by mixing Chinese medicinal extractive solution, abrasive, wetting agent, binder and foaming agent, stirring, grinding, and vacuum degassing to obtain toothpaste.
A preparation method of oral care solution of a pharmaceutical composition for treating gingivitis comprises sequentially adding surfactant, xylitol, sorbitol, Chinese medicinal extractive solution, magnesium lithium silicate and bacteriostatic agent into deionized water, and mixing to obtain oral care solution.
A method for preparing decoction of medicinal composition for treating gingivitis comprises mixing the Chinese medicinal extractive solution with deionized water at equal ratio, and sterilizing to obtain decoction of medicinal composition.
Example 3
A pharmaceutical composition for treating gingivitis comprises radix Aconiti lateralis Preparata, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: radix aconiti lateralis preparata 9 parts, dandelion 25 parts, honeysuckle 25 parts, mint 25 parts, isatis root 15 parts, cortex moutan 20 parts and mangnolia officinalis.
Further, the pharmaceutical composition further comprises: scutellariae radix, radix Ophiopogonis, flos Chrysanthemi, radix Paeoniae Rubra, radix asparagi, radix Angelicae Dahuricae and Saviae Miltiorrhizae radix.
Further, the medicinal composition comprises the following Chinese medicinal materials in parts by weight: 15 parts of scutellaria baicalensis, 9 parts of radix ophiopogonis, 12 parts of chrysanthemum, 8 parts of red paeony root, 8 parts of radix asparagi, 5 parts of radix angelicae and 5 parts of salvia miltiorrhiza.
A pharmaceutical composition for treating gingivitis and a preparation method thereof comprise the following steps:
the method comprises the following steps: processing radix Aconiti lateralis, removing toxicity to obtain radix Aconiti lateralis, and pulverizing radix Aconiti lateralis, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis;
step two: putting the powder of the monkshood, the dandelion, the honeysuckle, the mint, the radix isatidis, the cortex moutan and the mangnolia officinalis into a reflux extractor, adding a certain proportion of ethanol for reflux extraction, combining the extracting solutions, standing the extracting solution, filtering to obtain filtrate, performing reduced pressure concentration by using a rotary evaporator to remove the ethanol, and concentrating the filtrate to 0.1-1 g/mL to obtain a traditional Chinese medicine extracting solution;
step three: making the Chinese medicinal extractive solution into various Chinese medicinal preparations.
The processing method of the monkshood comprises the following steps:
the method comprises the following steps: removing fibrous root from fresh radix Aconiti lateralis, cleaning, and sun drying to obtain dried radix Aconiti lateralis;
step two: soaking the dry monkshood in purified water, taking out when the monkshood is semi-permeable, putting the semi-permeable monkshood into a medicine pool, and spraying purified water every two hours until the monkshood is completely moistened;
step three: steaming the radix Aconiti lateralis in a steam tank until the fragrance overflows, stopping steaming, taking out the radix Aconiti lateralis, slicing, and oven drying to obtain radix Aconiti lateralis.
The Chinese medicinal preparation is toothpaste, oral care solution or decoction.
A toothpaste containing Chinese medicinal composition for treating gingivitis is prepared by mixing Chinese medicinal extractive solution, abrasive, wetting agent, binder and foaming agent, stirring, grinding, and vacuum degassing to obtain toothpaste.
A preparation method of oral care solution of a pharmaceutical composition for treating gingivitis comprises sequentially adding surfactant, xylitol, sorbitol, Chinese medicinal extractive solution, magnesium lithium silicate and bacteriostatic agent into deionized water, and mixing to obtain oral care solution.
A method for preparing decoction of medicinal composition for treating gingivitis comprises mixing the Chinese medicinal extractive solution with deionized water at equal ratio, and sterilizing to obtain decoction of medicinal composition.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A pharmaceutical composition for treating gingivitis is characterized by comprising monkshood, dandelion, honeysuckle, mint, isatis root, cortex moutan and mangnolia officinalis.
2. The pharmaceutical composition for treating gingivitis according to claim 1, wherein the pharmaceutical composition comprises the following traditional Chinese medicinal materials in parts by weight: 6-9 parts of monkshood, 20-25 parts of dandelion, 20-25 parts of honeysuckle, 20-25 parts of mint, 10-15 parts of isatis root, 15-20 parts of cortex moutan and mangnolia officinalis.
3. The pharmaceutical composition for treating gingivitis according to claim 1, wherein said pharmaceutical composition further comprises: scutellariae radix, radix Ophiopogonis, flos Chrysanthemi, radix Paeoniae Rubra, radix asparagi, radix Angelicae Dahuricae and Saviae Miltiorrhizae radix.
4. The pharmaceutical composition for treating gingivitis according to claim 3, wherein the pharmaceutical composition comprises the following traditional Chinese medicinal materials in parts by weight: 12-15 parts of scutellaria baicalensis, 5-9 parts of radix ophiopogonis, 8-12 parts of chrysanthemum, 5-8 parts of red paeony root, 5-8 parts of asparagus, 3-5 parts of angelica dahurica and 3-5 parts of salvia miltiorrhiza.
5. The pharmaceutical composition for treating gingivitis and the preparation method thereof according to any one of claims 1 to 4, comprising the following steps:
the method comprises the following steps: processing radix Aconiti lateralis, removing toxicity to obtain radix Aconiti lateralis, and pulverizing radix Aconiti lateralis, herba Taraxaci, flos Lonicerae, herba Menthae, radix Isatidis, cortex moutan and cortex Magnolia officinalis;
step two: putting the powder of the aconite, the dandelion, the honeysuckle, the mint, the isatis root, the cortex moutan and the mangnolia officinalis into a reflux extractor, adding a certain proportion of ethanol for reflux extraction, combining the extracting solutions, standing the extracting solution, filtering to obtain filtrate, performing reduced pressure concentration by using a rotary evaporator to remove the ethanol, and concentrating the filtrate to 0.1-1 g/mL to obtain a traditional Chinese medicine extracting solution;
step three: making the Chinese medicinal extractive solution into various Chinese medicinal preparations.
6. The pharmaceutical composition for treating gingivitis and the preparation method thereof according to claim 5, wherein the processing method of the monkshood comprises the following steps:
the method comprises the following steps: removing fibrous root from fresh radix Aconiti lateralis, cleaning, and sun drying to obtain dried radix Aconiti lateralis;
step two: soaking the dry monkshood in purified water, taking out when the monkshood is semi-permeable, putting the semi-permeable monkshood into a medicine pool, and spraying purified water every two hours until the monkshood is completely moistened;
step three: steaming the radix Aconiti lateralis in a steam tank until the fragrance overflows, stopping steaming, taking out the radix Aconiti lateralis, slicing, and oven drying to obtain radix Aconiti lateralis.
7. The pharmaceutical composition for treating gingivitis and the preparation method thereof according to claim 5, wherein the traditional Chinese medicine preparation is toothpaste, oral care solution or decoction.
8. The method for preparing toothpaste containing pharmaceutical composition for treating gingivitis according to claim 7, wherein the toothpaste is obtained by mixing the traditional Chinese medicine extract, the abrasive, the wetting agent, the adhesive and the foaming agent, stirring, grinding and vacuum degassing.
9. The method for preparing the oral care solution of the pharmaceutical composition for treating gingivitis according to claim 7, wherein the surfactant, the xylitol, the sorbitol, the traditional Chinese medicine extract, the lithium magnesium silicate and the bacteriostatic agent are sequentially added into deionized water and uniformly mixed to obtain the oral care solution.
10. The method for preparing the decoction of the pharmaceutical composition for treating gingivitis according to claim 7, wherein the decoction of the pharmaceutical composition is obtained by mixing the traditional Chinese medicine extract with deionized water in equal proportion and then sterilizing.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133292A (en) * | 2011-02-28 | 2011-07-27 | 王磊 | Oral Chinese medicine preparation for treating chronic periodontitis and preparation method thereof |
| CN103156984A (en) * | 2013-04-03 | 2013-06-19 | 刘冰甜 | Traditional Chinese medicine composition for treating gingivitis and preparation method thereof |
| CN106937925A (en) * | 2017-03-03 | 2017-07-11 | 江苏康缘药业股份有限公司 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
| WO2021203648A1 (en) * | 2020-04-09 | 2021-10-14 | 四川绿色本草科技发展有限公司 | Traditional chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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2022
- 2022-05-13 CN CN202210521290.9A patent/CN114832036A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102133292A (en) * | 2011-02-28 | 2011-07-27 | 王磊 | Oral Chinese medicine preparation for treating chronic periodontitis and preparation method thereof |
| CN103156984A (en) * | 2013-04-03 | 2013-06-19 | 刘冰甜 | Traditional Chinese medicine composition for treating gingivitis and preparation method thereof |
| CN106937925A (en) * | 2017-03-03 | 2017-07-11 | 江苏康缘药业股份有限公司 | A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof |
| WO2021203648A1 (en) * | 2020-04-09 | 2021-10-14 | 四川绿色本草科技发展有限公司 | Traditional chinese medicine composition for preventing gingival atrophy and/or treating gingivitis |
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