CN102860971A - Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof - Google Patents
Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and a preparation method of the compound toothpaste. The invention adopts natural propolis and traditional Chinese medicine with functions of analgesia, anesthesia and antiallergic effect as main effective preparations, is compounded with the traditional western medicine and is supplemented by biotechnology, so that the compound toothpaste with the functions of antisepsis, anti-inflammation, acid prevention and desensitization can be prepared. The compound toothpaste can be used for preventing and treating periodontitis, dental ulcer, enamel trauma, toothache and sensitivity of teeth, and is also capable of enhancing the self repairing capability of oral cavity tissue, enabling the gum to be healthy, improving the microcirculation, guaranteeing the oral cavity to be healthy and improving the comprehensive antiallergic capability of teeth.
Description
Technical field
The present invention relates to the one way of life article of everyday use, particularly compound toothpaste of a kind of anti-inflammation, acid-proof desensitization and preparation method thereof.
Background technology
Toothpaste is daily necessities, and present toothpaste on the market is a feast for the eyes, consists of by similar basic functionality component but mostly count toothpaste, consists of such as abrasivus, wetting agent, surfactant, binding agent, spice, sweeting agent and other special composition.Quite a few is arranged in the toothpaste is toothpaste with fluoride, and the expert points out that child below 6 years old uses toothpaste with fluoride to have greater risk, because fluorine is a kind of noxious substance, excessive fluorine not only can cause tooth thin, more can reduce the hardness of bone.Also some medicated toothpaste by add medicine in toothpaste, can be treated oral disease; Such as the Radix Scutellariae toothpaste that occurs on the market, Herba Pileae Scriptae toothpaste etc., they have certain slowing down and therapeutical effect to gingival hemorrhage, red swelling of gingiva, halitosis, dentin hypersensitiveness disease etc., but there is function singleness in these toothpaste, the shortcoming of weak curative effect.In the daily life; people tooth often can occur and meet hot and cold, sour, sweet and produce phenomenon tingle, pain; the sensitivity of tooth that Here it is it has often been said, tracing it to its cause mostly is that dentin is exposed is caused because tooth abrasion, gingival atrophy, root of the tooth expose etc.Under external irritant, cause the endochylema projection conduction of dentin cell to cause responsive symptom, also can be because of the change of dental pulp blood circulation, such as the enamel wound, responsive symptom appears in the factors such as root of the tooth tip hyperemia, with advancing age, the frequency of sensitivity of tooth is more outstanding, has a strong impact on people's quality of the life.And the tooth inflammation such as periodontitis, oral ulcer and enamel wound also are the tooth common diseases, and these all bring certain slight illness to people, have affected people's orthobiosis.Therefore the safe produce effects of developmental research and have anti-inflammation concurrently and the multiple-effect compound toothpaste of acid-proof desensitization seems very important.
Summary of the invention
The object of the invention is to overcome defective of the prior art, compound toothpaste of a kind of anti-inflammation, acid-proof desensitization and preparation method thereof is provided, toothpaste of the present invention can be to periodontitis, oral ulcer, enamel wound, have a toothache and sensitivity of tooth has preventive and therapeutic action, can strengthen simultaneously self repair ability of oral cavity tissue, strong gingiva, improve microcirculation, healthy mouth improves the comprehensive antiallergic sense of tooth ability.
The present invention is achieved by the following technical programs.
The compound toothpaste of a kind of anti-inflammation, acid-proof desensitization, its constituent is as follows by mass parts:
The compound toothpaste of above-mentioned a kind of anti-inflammation, acid-proof desensitization, wherein, its constituent is as follows by mass parts:
The compound toothpaste of above-mentioned a kind of anti-inflammation, acid-proof desensitization, wherein, described propolis supercritical CO
2Extract is that propolis is through simulative biological fluid bed formula supercritical fluid CO
2The extract (CN101530178A) that extraction obtains.
The preparation method of the compound toothpaste of above-mentioned a kind of anti-inflammation, acid-proof desensitization, preparation process is as follows: at first that glycerol, sorbitol, silicon dioxide, titanium dioxide, sodium carboxymethyl cellulose, sodium laurylsulfate, xylitol is even with deionized water dissolving, then join in the vacuum Manufacturing medicine extract machine, add again the propolis supercritical CO
2Extract, strontium chloride, potassium nitrate, carbamide, Oleum Caryophylli, vitamin E Nicotinate, paeonol, Herba Asari, calcium hydroxy phosphate, add and carry out scraper plate after complete and stir and grind, control reaction temperature≤45 ℃, carry out simultaneously evacuation, be evacuated to vacuum and reach-0.096～-0.090MPa, pumpdown time 50-70min; Again the mastic that forms is naturally cooled to room temperature, be 80-120min standing time, mastic fully expanded form the adherend of homogeneous phase.
The preparation method of the compound toothpaste of above-mentioned a kind of anti-inflammation, acid-proof desensitization wherein, is evacuated to vacuum and reaches-0.096MPa.
The preparation method of the compound toothpaste of above-mentioned a kind of anti-inflammation, acid-proof desensitization, wherein, be 120 min standing time.
The various functional components of compound toothpaste of the present invention are described below:
Propolis is that Apis is picked resin from plant, natural gum, and sneak into lingual gland, the colloid substance that the body of gland process changes such as wax gland form.Propolis extract has broad-spectrum antiseptic, antiinflammatory, antisepsis, main component have flavonoid, phenols, lactone, etc. chemical compound and various vitamin, aminoacid, micro-first number, its pharmaceutical effect shows antibacterium, antiviral, antifungal, anti-inflammatory analgetic, particularly the propolis supercritical CO
2Terpenes in the extract, aromatics and ether material have direct topical anesthesia and analgesic activity, and golden yellow color does not contain heavy metal and dissolvent residual, without anaphylactogen.It has the disease that strengthens natural immunity, competent cell, removal toxin, antiinflammatory, antiallergic, multiple pathogenic microorganisms is caused and has extensive and good therapeutical effect, so propolis has and nourishes and the effect of protection gingiva.
The toothpaste of various propolis-containings of the prior art, the propolis extract of its use all adopt the alcohol extraction method to make, and the content of terpenoid substance is significantly less than supercritical CO in its extract
2The content of terpenoid substance in the extract that extracting process obtains, and extract is black, affects the color and luster of toothpaste, and have that wine is clear residually to bring anaphylactogen to gingiva, can not keep the aromatic odor of natural plants.
Thereby the strontium ion in strontium chloride and the potassium nitrate and potassium ion can improve Dentinal antiacid effect reaches desensitization analgesic effect, it can be penetrated into teeth roots, enter dentinal tubule, calcium in tissue of tooth is combined, sealing dentinal tubule, cut off the conduction of dentin and Intradental nerve, prevent that with this tooth from aching.
Carbamide can suppress growing of lactobacillus, plays desensitization thereby dissolve facing speckle film and form new protecting film.
Oleum Caryophylli is that the cloves Herba Ocimi (Herba Ocimi Pilosi) is through supercritical CO
2Extract and get, can anaesthetize dental nerve and slow down stimulation and play analgesic effect.
Paeonol is that the dry root bark of Paeonia suffruticosa is through supercritical CO
2Extraction and getting has the central inhibitory actions such as calmness, analgesic, analgesia, spasmolytic, and effective cure rate of the dentin hypersensitiveness that periodontitis, gingivitis etc. is caused reaches more than 90%.
Herba Asari has the effect of maincenter inhibition, analgesia and local anesthesia.
Vitamin E Nicotinate has vasodilator, the sanguimotor effect of auxiliary improvement.
Calcium hydroxy phosphate has the effect of eliminating tartar, the repair teeth little breakage in surface.
The compound toothpaste of a kind of anti-inflammation of the present invention, acid-proof desensitization, adopting natural propolis and the Chinese medicine with analgesia, anesthesia, anti-allergic effects is main effect preparation, compound recipe tradition Western medicine is aided with biotechnology and makes the compound toothpaste that has anti-inflammation and acid-proof desensitization concurrently.Adopt the targeting of propolis antiinflammatory and Chinese medicine analgesia, anesthesia, hypo-allergenic again combined with westem, can seal dentinal tubule, suppress liquid flow in the canaliculi dentales, cut off the conduction of dentin and Intradental nerve, the irritability of calm Intradental nerve, reduction Intradental nerve tip; The while propolis is repairing dental enamel initiatively, promotes tooth enamel surface remineralization, thereby improves the immunocompetence of tooth.Toothpaste of the present invention can be to periodontitis, oral ulcer, enamel wound, have a toothache and sensitivity of tooth has preventive and therapeutic action, can strengthen simultaneously self repair ability of oral cavity tissue, strong gingiva, improve microcirculation, healthy mouth improves the comprehensive antiallergic sense of tooth ability.
The specific embodiment
Embodiment 1
The preparation method of the compound toothpaste of a kind of anti-inflammation, acid-proof desensitization, preparation process is as follows: at first with 19 parts of glycerol, 38.2 parts of sorbitol, 20.8 parts of silicon dioxide, 0.38 part of titanium dioxide, 0.65 part of sodium carboxymethyl cellulose, 2.3 parts of sodium laurylsulfates, 0.075 part of xylitol, with 7.25 parts of dissolvings of deionized water evenly, then join in the vacuum Manufacturing medicine extract machine, add again the propolis supercritical CO
24 parts of extracts, 1.8 parts of strontium chlorides, 2.1 parts of potassium nitrate, 2.1 parts in carbamide, 0.075 part of Oleum Caryophylli, 0.15 part of vitamin E Nicotinate, 0.15 part of paeonol, 0.75 part of Herba Asari, 2.0 parts of calcium hydroxy phosphates, add and carry out scraper plate after complete and stir and grind, it is 45 ℃ with chuck cooling water control reaction temperature, carry out simultaneously evacuation, be evacuated to vacuum and reach-0.096MPa, the pumpdown time is 50min; Again the mastic that forms is naturally cooled to room temperature, be 120min standing time, mastic fully expanded form the adherend of homogeneous phase.
Embodiment 2
The preparation method of the compound toothpaste of a kind of anti-inflammation, acid-proof desensitization, preparation process is as follows: at first with 18.6 parts of glycerol, 36.6 parts of sorbitol, 20.3 parts of silicon dioxide, 0.3 part of titanium dioxide, 0.6 part of sodium carboxymethyl cellulose, 2 parts of sodium laurylsulfates, 0.05 part of xylitol, with 6.7 parts of dissolvings of deionized water evenly, then join in the vacuum Manufacturing medicine extract machine, add again the propolis supercritical CO
23 parts of extracts, 1.15 parts of strontium chlorides, 1.8 parts of potassium nitrate, 1.98 parts in carbamide, 0.05 part of Oleum Caryophylli, 0.1 part of vitamin E Nicotinate, 0.12 part of paeonol, 0.5 part of Herba Asari, 1.8 parts of calcium hydroxy phosphates, add and carry out scraper plate after complete and stir and grind, it is 40 ℃ with chuck cooling water control reaction temperature, carry out simultaneously evacuation, be evacuated to vacuum and reach-0.092MPa, the pumpdown time is 60min; Again the mastic that forms is naturally cooled to room temperature, be 100min standing time, mastic fully expanded form the adherend of homogeneous phase.
Embodiment 3
The preparation method of the compound toothpaste of a kind of anti-inflammation, acid-proof desensitization, preparation process is as follows: at first with 19.2 parts of glycerol, 38.4 parts of sorbitol, 21.2 parts of silicon dioxide, 0.45 part of titanium dioxide, 0.7 part of sodium carboxymethyl cellulose, 2.6 parts of sodium laurylsulfates, 0.1 part of xylitol, with 7.5 parts of dissolvings of deionized water evenly, then join in the vacuum Manufacturing medicine extract machine, add again the propolis supercritical CO
25 parts of extracts, 2.5 parts of strontium chlorides, 2.36 parts of potassium nitrate, 2.38 parts in carbamide, 0.1 part of Oleum Caryophylli, 0.2 part of vitamin E Nicotinate, 0.2 part of paeonol, 1 part of Herba Asari, 2.2 parts of calcium hydroxy phosphates, add and carry out scraper plate after complete and stir and grind, it is 35 ℃ with chuck cooling water control reaction temperature, carry out simultaneously evacuation, be evacuated to vacuum and reach-0.090MPa, the pumpdown time is 70min; Again the mastic that forms is naturally cooled to room temperature, be 80min standing time, mastic fully expanded form the adherend of homogeneous phase.
Compound toothpaste of the present invention is detected by GB8372, and the result is qualified, and stability reaches in the time of 45 ℃ placed 30-45 days, and mastic do not return slightly, do not separate, loss of gloss pool.
Sensory test: blind test is brushed teeth 100 person-times, feels slightly puckery 13 person-times, 12 person-times of sensation bitterness, and all the other mouthfeels are and can accept.
Bacteriostatic test: the bacterial plaque of getting 50 patients with periodontal disease facings of Stomatology Clinic scraping is tested, and the result proves that compound toothpaste of the present invention has certain bacteriostasis to the totally six kinds of pathogenic bacterias that comprise actinobacillus actinomycetem comitans, gingiva bacteroid, middle type bacteroid, Eubacterium, bacteroides melanogenicus, treponema and peptostreptococcus through the anaerobic condition culture identification.
1 minute analgesia desensitization test: 100 person-times of odonthemodia patients brush teeth, stimulates with cold water and air-flow after 1 minute, and produce effects number 22 people as a result, efficiently individual quantity is more than 82, and 2 people are without obvious sensation.
The experimenter adheres to using compound toothpaste of the present invention every day, and each 1 time sooner or later, each about 3 minutes, after 45 days, the experimenter felt that obviously the sensitivity of tooth degree reduces, and the tooth alleviation of aching all has desensitization effect, and particularly propolis extract content is high is produce effects.
Here description of the invention and application is illustrative, is not to want that therefore, the present invention is not subjected to the restriction of present embodiment with scope restriction of the present invention in the above-described embodiments, and the technical scheme that any employing equivalence replacement obtains is all in the scope of protection of the invention.
Claims (6)
1. the compound toothpaste of an anti-inflammation, acid-proof desensitization is characterized in that its constituent is as follows by mass parts:
Glycerol: 18.6-19.2 part
Sorbitol: 36.6-38.4 part
Silicon dioxide: 20.3-21.2 part
Titanium dioxide: 0.3-0.45 part
Sodium carboxymethyl cellulose: 0.6-0.7 part
Sodium laurylsulfate: 2-2.6 part
Xylitol: 0.05-0.1 part
Deionized water: 6.7-7.5 part
The propolis supercritical CO
2Extract: 3-5 part
Strontium chloride: 1.15-2.50 part
Potassium nitrate: 1.8-2.36 part
Carbamide: 1.98-2.38 part
Oleum Caryophylli: 0.05-0.1 part
Vitamin E Nicotinate: 0.1-0.2 part
Paeonol: 0.12-0.2 part
Herba Asari 0.5-1.0 part
Calcium hydroxy phosphate: 1.8-2.2 part.
2. the compound toothpaste of a kind of anti-inflammation as claimed in claim 1, acid-proof desensitization is characterized in that its constituent is as follows by mass parts:
Glycerol: 19 parts
Sorbitol: 38.2 parts
Silicon dioxide: 20.8 parts
Titanium dioxide: 0.38 part
Sodium carboxymethyl cellulose: 0.65 part
Sodium laurylsulfate: 2.3 parts
Xylitol: 0.075 part
Deionized water: 7.25 parts
The propolis supercritical CO
2Extract: 4 parts
Strontium chloride: 1.8 parts
Potassium nitrate: 2.1 parts
Carbamide: 2.1 parts
Oleum Caryophylli: 0.075 part
Vitamin E Nicotinate: 0.15 part
Paeonol: 0.15 part
0.75 part of Herba Asari
Calcium hydroxy phosphate: 2.0 parts.
3. the compound toothpaste of a kind of anti-inflammation as claimed in claim 1 or 2, acid-proof desensitization is characterized in that described propolis supercritical CO
2Extract is that propolis is through simulative biological fluid bed formula supercritical fluid CO
2The extract that extraction obtains.
4. the preparation method of the compound toothpaste of a kind of anti-inflammation as claimed in claim 1, acid-proof desensitization, it is characterized in that, preparation process is as follows: at first that glycerol, sorbitol, silicon dioxide, titanium dioxide, sodium carboxymethyl cellulose, sodium laurylsulfate, xylitol is even with deionized water dissolving, then join in the vacuum Manufacturing medicine extract machine, add again the propolis supercritical CO
2Extract, strontium chloride, potassium nitrate, carbamide, Oleum Caryophylli, vitamin E Nicotinate, paeonol, Herba Asari, calcium hydroxy phosphate, add and carry out scraper plate after complete and stir and grind, control reaction temperature≤45 ℃, carry out simultaneously evacuation, be evacuated to vacuum and reach-0.096～-0.090MPa, pumpdown time 50-70min; Again the mastic that forms is naturally cooled to room temperature, be 80-120min standing time, mastic fully expanded form the adherend of homogeneous phase.
5. the preparation method of the compound toothpaste of a kind of anti-inflammation as claimed in claim 4, acid-proof desensitization is characterized in that, is evacuated to vacuum and reaches-0.096MPa.
6. the preparation method of the compound toothpaste of a kind of anti-inflammation as claimed in claim 4, acid-proof desensitization is characterized in that be 120 min standing time.
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| CN201210349766.1A CN102860971B (en) | 2012-09-19 | 2012-09-19 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
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| CN201210349766.1A CN102860971B (en) | 2012-09-19 | 2012-09-19 | Compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and preparation method thereof |
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Cited By (13)
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| CN104306268A (en) * | 2014-11-03 | 2015-01-28 | 广州百草堂药业有限公司 | Oral care product and extraction method of composition |
| CN105769924A (en) * | 2016-04-15 | 2016-07-20 | 湖北艾莱福生物科技有限公司 | Propolis oral antifungal cream and preparing method thereof |
| CN106581078A (en) * | 2017-03-01 | 2017-04-26 | 四川天福精细化工有限公司 | Oral desensitization paste and preparation method thereof |
| CN106668063A (en) * | 2017-02-13 | 2017-05-17 | 郑州呀可宁医用设备有限公司 | Desensitization hemostatic gel and preparation method thereof |
| CN107028799A (en) * | 2017-02-21 | 2017-08-11 | 广州薇美姿实业有限公司 | A kind of oral cavity baste of antiallergic whitening |
| CN108030706A (en) * | 2017-12-15 | 2018-05-15 | 上海美加净日化有限公司 | Double antianaphylaxis tooth paste containing Paeonol and strontium salt |
| CN108685763A (en) * | 2018-08-16 | 2018-10-23 | 苏州清馨健康科技有限公司 | A kind of multiple antiallergic toothpaste |
| CN108836888A (en) * | 2018-04-25 | 2018-11-20 | 佛山科学技术学院 | A kind of tooth antiallergic composition |
| CN111686021A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Toothpaste for relieving dentin sensitivity |
| CN112137948A (en) * | 2020-11-11 | 2020-12-29 | 上海古腊国际贸易有限公司 | Antibacterial soothing toothpaste and preparation method thereof |
| CN112754984A (en) * | 2021-03-11 | 2021-05-07 | 傅博 | Anti-sensitivity liquid toothpaste and preparation method thereof |
| CN113197830A (en) * | 2021-04-29 | 2021-08-03 | 北京德创未来生物技术有限公司 | Multifunctional toothpaste and preparation method thereof |
| CN113730440A (en) * | 2021-09-14 | 2021-12-03 | 康博士日化集团有限公司 | Antibacterial composition and oral care product containing same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104306268A (en) * | 2014-11-03 | 2015-01-28 | 广州百草堂药业有限公司 | Oral care product and extraction method of composition |
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| CN108030706A (en) * | 2017-12-15 | 2018-05-15 | 上海美加净日化有限公司 | Double antianaphylaxis tooth paste containing Paeonol and strontium salt |
| CN108836888A (en) * | 2018-04-25 | 2018-11-20 | 佛山科学技术学院 | A kind of tooth antiallergic composition |
| CN108685763A (en) * | 2018-08-16 | 2018-10-23 | 苏州清馨健康科技有限公司 | A kind of multiple antiallergic toothpaste |
| CN111686021A (en) * | 2020-07-27 | 2020-09-22 | 浙江爱尚日用品有限公司 | Toothpaste for relieving dentin sensitivity |
| CN112137948A (en) * | 2020-11-11 | 2020-12-29 | 上海古腊国际贸易有限公司 | Antibacterial soothing toothpaste and preparation method thereof |
| CN112754984A (en) * | 2021-03-11 | 2021-05-07 | 傅博 | Anti-sensitivity liquid toothpaste and preparation method thereof |
| CN113197830A (en) * | 2021-04-29 | 2021-08-03 | 北京德创未来生物技术有限公司 | Multifunctional toothpaste and preparation method thereof |
| CN113730440A (en) * | 2021-09-14 | 2021-12-03 | 康博士日化集团有限公司 | Antibacterial composition and oral care product containing same |
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| CN102860971B (en) | 2014-03-26 |
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Address after: 212009 hi tech Industrial Park, Jiangsu, Zhenjiang, No. four, No. 2 Patentee after: JIANGSU JIANGDAYUAN ECOLOGICAL BIOLOGICAL TECHNOLOGY CO., LTD. Address before: No. four, No. 2, Zhenjiang hi tech Industrial Park, Jiangsu, China Patentee before: Jiangsu Jiangdayuan Ecology Biological Technology Co.,Ltd. |