CN108030706A - Double antianaphylaxis tooth paste containing Paeonol and strontium salt - Google Patents
Double antianaphylaxis tooth paste containing Paeonol and strontium salt Download PDFInfo
- Publication number
- CN108030706A CN108030706A CN201711352867.3A CN201711352867A CN108030706A CN 108030706 A CN108030706 A CN 108030706A CN 201711352867 A CN201711352867 A CN 201711352867A CN 108030706 A CN108030706 A CN 108030706A
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- Prior art keywords
- strontium salt
- paeonol
- antianaphylaxis
- double
- tooth paste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides the double antianaphylaxis tooth paste containing Paeonol and strontium salt, including antiallergic component and base ingredients；The antiallergic component includes strontium salt and Paeonol, wherein, the percentage by weight that the strontium salt accounts for whole toothpaste component is 1.0%~3.0%, and the percentage by weight that the Paeonol accounts for whole toothpaste component is 0.2%~1.0%；The base ingredients include moisturizer, rubbing agent, surfactant, thickener, sweetener, spices, pigment, lotion stabilizer, preservative and water.The present invention is made an addition in toothpaste base-material using the Paeonol and strontium salt of specific proportioning, and mentioned component complements each other, and acts synergistically on dental nerve, has significant antiallergic effect.
Description
Technical field
The present invention relates to a kind of toothpaste, more particularly to a kind of antiallergy toothpaste.
Background technology
Sensitivity of tooth is commonly called as " setting one's teeth on edge ", caused by being due to dentine expose, open tubules.
According to the survey data of dentistry tissue, the adult of Chinese 20-60 Sui accounts for 30% with sensitivity of tooth, 60 years old
Old man above accounts for 80% with sensitivity of tooth, and comprehensive both of these case, the Chinese for accounting for total population 39% have tooth
Tender subject.Just have to brush teeth using antiallergy toothpaste during symptom because aching occurs in sensitivity of tooth as consumer.
Antiallergy toothpaste is to be exclusively used in being subject to environmental stimuli by brushing teeth to alleviate tooth, such as temperature (hot and cold), chemicals
Allergy caused by matter (acid, sweet tea), mechanism (rub, sting hard thing) etc. is ached symptom.
Antiallergy toothpaste on the market, as Luclean double antianaphylaxis tooth paste use strontium chloride and potassium nitrate as antiallergic into
Point, there is good antiallergic effect, but the addition of substantial amounts of chemical composition easily produces tolerance, especially with one
After the section time, antiallergic effect can be affected.
China is Chinese medicine big country, has abundant natural resources of Chinese medicinal materials.Chinese medicine has toxic side effect small, is not likely to produce tolerance
Feature, and Chinese medicine has the effect of fine on antibacterial anti-inflammatory, pain easing and hemostasis.
The content of the invention
The defects of it is an object of the invention to overcome in the prior art, there is provided the dual antiallergy tooth containing Paeonol and strontium salt
Cream, is made an addition in toothpaste base-material using the Paeonol and strontium salt of specific proportioning, and mentioned component complements each other, and acts synergistically on tooth god
Through having significant antiallergic effect.
To achieve the above object, the present invention adopts the following technical scheme that：
Double antianaphylaxis tooth paste containing Paeonol and strontium salt, including antiallergic component and base ingredients；
The antiallergic component includes strontium salt and Paeonol, wherein, the strontium salt accounts for the percentage by weight of whole toothpaste component
For 1.0%~3.0%, the percentage by weight that the Paeonol accounts for whole toothpaste component is 0.2%~1.0%；
The base ingredients include moisturizer, rubbing agent, surfactant, thickener, sweetener, spices, pigment, lotion
Stabilizer, preservative and water.
In order to further optimize above-mentioned clinical nutrition formula, the technical measures that the present invention is taken further include：
Preferably, the strontium salt is strontium chloride, it accounts for the percentage by weight of whole toothpaste component as 2.0%.
Preferably, the percentage by weight that the Paeonol accounts for whole toothpaste component is 0.5%.
Preferably, each component and its percentage by weight are as follows in the base ingredients：
Wherein, the moisturizer is mixture more than one or both of sorbierite, glycerine, PEG；
The rubbing agent is mixing more than one or both of silica, calcium carbonate, calcium monohydrogen phosphate, aluminium hydroxide
Thing；
The surfactant is lauryl sodium sulfate, N- sarcosinates, Cocoamidopropyl betaine, pool Lip river
Mixture more than one or both of husky nurse；
The thickener is mixture more than one or both of CMC, HEC, carragheen, xanthans, guar gum；
The sweetener is mixing more than one or both of saccharin sodium, Abbas's sweet tea, antierythrite, xylitol
Thing；
The spices is the mixture of one or both of Mint Essence, spearmint essence；
The pigment is the mixture of one or both of CI77891, CI42090；
The lotion stabilizer is mixing more than one or both of tertiary sodium phosphate, sodium pyrophosphate, sodium dihydrogen phosphate
Thing；
The preservative is the mixture of one or both of benzenpropanoic acid sodium, phenmethylol；
The water is deionized water.
The present invention, which uses, includes Paeonol and the antiallergic component of strontium salt is made an addition in toothpaste base-material, also defines Paeonol
With the per distribution ratio of strontium salt, the effect with dual antiallergic after mentioned component compatibility synergy.
Paeonol is also known as paeonol, peonol, its chemical composition is mainly 2- hydroxyl -4- methoxybenzene acetone, mainly
Extract and obtain from peony root skin, belong to Chinese herbal medicine extract, the drug action with prevention and treatment sensitivity of tooth；In strontium salt
Strontium ion be then used as sealer, open dentinal tubule can be blocked, so that sensitivity of tooth is eased；
The effect of research shows, medicine is produced by the interaction between drug molecule and biological receptor molecules,
The present invention also added the base ingredients and strontium salt of said components and proportioning in toothpaste, its environment provided helps to carry
The bioavilability of high Paeonol, strengthens its drug effect, antiallergic effect is better achieved.
The present invention is absorbed in the prevention and treatment of hemodia, and the double action of Paeonol and strontium salt, not only alleviates and work as
Under hemodia symptom, and prevent and treated the oral problem of hemodia on long-range.
The present invention uses above-mentioned technical proposal, compared with prior art, has the following technical effect that：
1) present invention is made an addition in toothpaste base-material using the Paeonol and strontium salt of specific proportioning, and mentioned component complements each other,
Dental nerve is acted synergistically on, there is significant antiallergic effect.
2) clinical test results show, toothpaste of the invention has significant analgesia desensitization treatment effect, real-time and long
There is higher effective percentage in the therapeutic effect of phase.
Embodiment
The present invention provides a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt.
With reference to embodiment, the embodiment of the present invention is further described.Following embodiments are only used for more
Add and clearly demonstrate technical scheme, and be not intended to limit the protection scope of the present invention and limit the scope of the invention.
Embodiment 1
The present invention provides a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt, its each component and its weight percent are such as
Under：
The lotion of toothpaste production method of above-mentioned formula is：At normal temperatures, the sorbierite weighed and glycerine are added into cream processed
Stirred in machine；Again successively by carragheen, strontium chloride, lauryl sodium sulfate, saccharin sodium, CI77891, tertiary sodium phosphate, benzenpropanoic acid
In sodium input Manufacturing medicine extract machine, Paeonol is completely dissolved in deionized water, adds Manufacturing medicine extract machine, strong stirring is uniform；Add two
Silica, stirs evenly, and then vacuumizes stirring；In last Mint Essence suction Manufacturing medicine extract machine, stir evenly, deaerate, cream is made
Body.
Embodiment 2
The present invention provides a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt, its each component and its weight percent are such as
Under：
The lotion of toothpaste production method of above-mentioned formula is：At normal temperatures, the sorbierite weighed and glycerine are added into cream processed
Stirred in machine；Again successively by carragheen, guar gum, strontium chloride, lauryl sodium sulfate, xylitol, CI77891, sodium pyrophosphate,
In benzenpropanoic acid sodium input Manufacturing medicine extract machine, Paeonol is completely dissolved in deionized water, adds Manufacturing medicine extract machine, strong stirring is uniform；Again
Calcium carbonate and calcium monohydrogen phosphate are added, stirs evenly, then vacuumizes stirring；In last Mint Essence suction Manufacturing medicine extract machine, stirring is equal
Even, degassing, is made lotion.
Embodiment 3
The present invention provides a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt, its each component and its weight percent are such as
Under：
The lotion of toothpaste production method of above-mentioned formula is：At normal temperatures, the sorbierite weighed is added in Manufacturing medicine extract machine and stirred
Mix；Again successively by CMC, strontium chloride, N- sarcosinates, xylitol, CI77891, tertiary sodium phosphate, sodium dihydrogen phosphate, benzene first
In alcohol input Manufacturing medicine extract machine, Paeonol is completely dissolved in deionized water, adds Manufacturing medicine extract machine, strong stirring is uniform；Add phosphorus
Sour hydrogen calcium, stirs evenly, and then vacuumizes stirring；In last Mint Essence suction Manufacturing medicine extract machine, stir evenly, deaerate, cream is made
Body.
Embodiment 4
1) the real-time dental sensitivity treatment effect of toothpaste prepared by the present invention
Take the embodiment of the present invention 1~3 to prepare lotion of toothpaste to be tested, while control group 1 and control group 2 are set, compare
Group is respectively control group 1 using the made antiallergy toothpaste of known formulations：Strontium chloride 0.5%, Paeonol 0.1%, remaining is tooth
Cream base material；Control group 2：Strontium chloride 4%, Paeonol 2.5%, remaining is toothpaste base-material.
Choose 100 person-times and carry out blind experiment with odontalgia hemodia patient, every group of 20 people, brushing time makes after 1 minute
Gargled with cold water stimulates with air-flow.
Criterion is：It is effective：No any feeling of pain (having remarkable result)；Effectively：There is sense of discomfort but substantially painless
(effective)；Generally：There is feeling of pain but can still endure and (have general effect)；It is invalid：There is feeling of pain and be difficult to endure (without obvious effect
Fruit).
Its experimental result such as table 1 below：
The real-time dental sensitivity treatment effect of a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt of table 1 (n (%))
The double antianaphylaxis tooth paste of the present invention has significant analgesia desensitization treatment effect it can be seen from the result of table 1,
Efficient on real-time dental sensitivity treatment is 100%.
2) the long-term dental sensitivity treatment effect of toothpaste prepared by the present invention
Take the embodiment of the present invention 1~3 to prepare lotion of toothpaste to be tested, while control group 1 and control group 2 are set, compare
Group is respectively control group 1 using the made antiallergy toothpaste of known formulations：Strontium chloride 0.5%, Paeonol 0.1%, remaining is tooth
Cream base material；Control group 2：Strontium chloride 4%, Paeonol 2.5%, remaining is toothpaste base-material.
Choose 100 person-times and carry out blind experiment with odontalgia hemodia patient, every group of 20 people, brush teeth, every time sooner or later daily
Brush teeth 3 minutes, persistently using after 2 months, carry out probe acute test.
Probe acute is tested：The test of sensitivity of tooth index, probe contact are carried out using electron pressure responsive probe
The dentine of the cheek surface exposure of chosen tooth, is placed on enamel essence intersection, sets the strength of probe contact as 50g.
Criterion is：0：Probe is contacted without any feeling of pain；1：Probe contact is slightly uncomfortable, substantially painless；2：
Probe has feeling of pain when contacting, but can still endure；3：Probe has severe pain to feel when contacting, it is impossible to endure.Subjective assessment：0~2
=improve；3=is without change.
Its experimental result such as table 2 below：
The long-term dental sensitivity treatment effect of a kind of double antianaphylaxis tooth paste containing Paeonol and strontium salt of table 2 (n (%))
The double antianaphylaxis tooth paste of the present invention has significant analgesia desensitization treatment effect it can be seen from the result of table 2,
Improvement rate on long-term dental sensitivity treatment is substantially better than control group 1.
Meanwhile inventor has found by test of many times, the antianaphylactic therapeutic effect of toothpaste and strontium salt and Paeonol in toothpaste
Content correlation：When strontium salt content is 1.0% in toothpaste, when paeonol content is 0.2%, treatment improvement rate reaches
90%；When strontium salt content is 2.0% in toothpaste, when paeonol content is 0.5%, treatment improvement rate reaches 95%；When in toothpaste
When strontium salt content continues increase with paeonol content, it is constant that treatment improvement rate maintains essentially in 95%.Due to consideration that in toothpaste
Strontium salt excessively or causes chemical content in toothpaste excessive with paeonol content, and financial cost increase, so inventor limits
Number range described in book as described above.
From above-described embodiment, the double antianaphylaxis tooth paste of the present invention containing Paeonol and strontium salt is matched somebody with somebody using specific
The Paeonol and strontium salt of ratio are made an addition in toothpaste base-material, and mentioned component complements each other, and acts synergistically on dental nerve, are had significant
Antiallergic effect.
The specific embodiment of the present invention is described in detail above, but it is intended only as example, it is of the invention and unlimited
It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and
Substitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and
Modification, all should be contained within the scope of the invention.
Claims (10)
1. the double antianaphylaxis tooth paste containing Paeonol and strontium salt, including antiallergic component and base ingredients, it is characterised in that described anti-
Quick component includes strontium salt and Paeonol, wherein, the percentage by weight that the strontium salt accounts for whole toothpaste component is 1.0%~3.0%,
The percentage by weight that the Paeonol accounts for whole toothpaste component is 0.2%~1.0%；
The base ingredients include moisturizer, rubbing agent, surfactant, thickener, sweetener, spices, pigment, lotion and stablize
Agent, preservative and water.
2. the double antianaphylaxis tooth paste according to claim 1 containing Paeonol and strontium salt, it is characterised in that the strontium salt is
Strontium chloride, it accounts for the percentage by weight of whole toothpaste component as 2.0%.
3. the double antianaphylaxis tooth paste according to claim 1 containing Paeonol and strontium salt, it is characterised in that the Paeonol
The percentage by weight for accounting for whole toothpaste component is 0.5%.
4. the double antianaphylaxis tooth paste according to claim 1 containing Paeonol and strontium salt, it is characterised in that the base-material into
Each component and its percentage by weight are as follows in point：
5. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that the moisturizer
For mixture more than one or both of sorbierite, glycerine, PEG.
6. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that the rubbing agent
For mixture more than one or both of silica, calcium carbonate, calcium monohydrogen phosphate, aluminium hydroxide.
7. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that live on the surface
Property agent be lauryl sodium sulfate, N- sarcosinates, Cocoamidopropyl betaine, one or both of poloxamer
Mixture above.
8. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that the thickener
For mixture more than one or both of CMC, HEC, carragheen, xanthans, guar gum.
9. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that the sweetener
For mixture more than one or both of saccharin sodium, Abbas's sweet tea, antierythrite, xylitol.
10. the double antianaphylaxis tooth paste according to claim 4 containing Paeonol and strontium salt, it is characterised in that the lotion
Stabilizer is mixture more than one or both of tertiary sodium phosphate, sodium pyrophosphate, sodium dihydrogen phosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711352867.3A CN108030706A (en) | 2017-12-15 | 2017-12-15 | Double antianaphylaxis tooth paste containing Paeonol and strontium salt |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711352867.3A CN108030706A (en) | 2017-12-15 | 2017-12-15 | Double antianaphylaxis tooth paste containing Paeonol and strontium salt |
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| CN201711352867.3A Pending CN108030706A (en) | 2017-12-15 | 2017-12-15 | Double antianaphylaxis tooth paste containing Paeonol and strontium salt |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108685763A (en) * | 2018-08-16 | 2018-10-23 | 苏州清馨健康科技有限公司 | A kind of multiple antiallergic toothpaste |
| CN108728388A (en) * | 2018-07-24 | 2018-11-02 | 上海美加净日化有限公司 | Porphyromonas gingivalis, resisting porphyromonas gingivalis specific IgY preparation and Compound formula of toothpaste |
| CN109330942A (en) * | 2018-11-22 | 2019-02-15 | 林锡慧 | A kind of formulation of tooth-paste containing oral cavity probiotics |
| CN110507580A (en) * | 2019-09-20 | 2019-11-29 | 广东大鹏医药科技有限公司 | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof |
| CN111135127A (en) * | 2020-01-19 | 2020-05-12 | 广东立爽生物科技有限公司 | Allergy-relieving and bleeding-stopping toothpaste and preparation method thereof |
| WO2023035387A1 (en) * | 2021-09-07 | 2023-03-16 | 重庆登康口腔护理用品股份有限公司 | Composition having good biocompatibility and use thereof in oral products |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108728388A (en) * | 2018-07-24 | 2018-11-02 | 上海美加净日化有限公司 | Porphyromonas gingivalis, resisting porphyromonas gingivalis specific IgY preparation and Compound formula of toothpaste |
| CN108685763A (en) * | 2018-08-16 | 2018-10-23 | 苏州清馨健康科技有限公司 | A kind of multiple antiallergic toothpaste |
| CN109330942A (en) * | 2018-11-22 | 2019-02-15 | 林锡慧 | A kind of formulation of tooth-paste containing oral cavity probiotics |
| CN110507580A (en) * | 2019-09-20 | 2019-11-29 | 广东大鹏医药科技有限公司 | A kind of toothpaste of the ingredient containing trollflower and preparation method thereof |
| CN111135127A (en) * | 2020-01-19 | 2020-05-12 | 广东立爽生物科技有限公司 | Allergy-relieving and bleeding-stopping toothpaste and preparation method thereof |
| WO2023035387A1 (en) * | 2021-09-07 | 2023-03-16 | 重庆登康口腔护理用品股份有限公司 | Composition having good biocompatibility and use thereof in oral products |
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