CN106726773A - A kind of whitening stain removing toothpaste and preparation method thereof - Google Patents
A kind of whitening stain removing toothpaste and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/733—Alginic acid; Salts thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to daily chemical product technical field, and in particular to a kind of whitening stain removing toothpaste and preparation method thereof.The whitening stain removing toothpaste that the present invention is provided includes following components and its parts by weight：69 parts of propane diols, 8 10 parts of sorbierite, 8 24 parts of silica 1,26 30 parts of calcium pyrophosphate, 0.4 0.8 parts of peppermint oil, 0.02 0.06 parts of saccharin sodium, 0.1 0.3 parts of propylben, 0.5 1.6 parts of Cocoamidopropyl betaine, 0.3 1.2 parts of xanthans, 0.03 0.08 parts of xylitol, 0.05 0.12 parts of methyl p-hydroxybenzoate, 0.2 0.5 parts of tea tree ethereal oil, 35 parts of perlite, 14 25 parts of 0.8 1.6 parts of Fructus Chaenomelis ferment, 12 parts of stannous pyrophosphate, 0.5 1 parts of sodium alginate and deionized water.The whitening stain removing toothpaste that the present invention is provided can effectively remove color stain, dental plaque, tooth-whitening.
Description
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of whitening stain removing toothpaste and preparation method thereof.
Background technology
Toothpaste is indispensable oral cleaning amenities in people's daily life, and its basic function is to clean tooth
Tooth, fresh breath, reach the purpose for keeping oral cleaning.In recent years, the requirement due to consumer to self-image constantly strengthens,
More requirements are proposed to toothpaste, the function of some auxiliary tooth-whitening effects is also add except cleaning one's teeth.
Chinese patent application CN103690389A discloses a kind of whitening toothpaste, including：Lanthanum chloride 2.3%-22.4%, phosphorus
Sour hydrogen calcium 1.2%-24.8%, sorbierite 1.3%-17.7%, sldium lauryl sulfate 2.1%-18.5%, essence 1.5%-
12.4%, rubbing agent 1.3%-7.2%, foam brightening agent 2.5%-10.7%, saccharin 3.6%-18.2%.Chinese patent application
CN106074339A discloses a kind of whitening toothpaste, is made up of the raw material of following mass fraction：Aluminum oxide 8-14 parts, lanthanum chloride 5-
7 parts, silica 4-6 parts, hydroxyethyl cellulose 3-5 parts, isopropanol 3-4 parts, Poria cocos 7-9 parts, root of Dahurain angelica 6-8 parts, bighead atractylodes rhizome 2-4
Part, vitamin C 6-8 parts, pearl powder 6-9 parts, calcium monohydrogen phosphate 5-7 parts, sorbierite 4-7 parts, sldium lauryl sulfate 5-8 parts.
Many people wish to possess the pure white tooth of a bite, therefore, often tooth whitening is placed hope on various with whitening
With the toothpaste of effect.Also have in existing toothpaste and gone as the auxiliary whitening of toothpaste using special rubbing agent or peroxide
Stain composition.But, the enamel of dental surface can be destroyed by the toothpaste of particle friction, dental surface is become coarse, tooth stain
It is easier to be deposited on dental surface.Oxidiferous toothpaste its main component is hydrogen peroxide, although its concentration is relatively low, but still have can
Certain stimulation can be caused to the oral cavity of a part of sensitive group, such as turned sour, be afraid of cool, swelling, in addition, stain tooth is removed in existing whitening
The whitening stain-removing effect of cream is not obvious.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of whitening stain removing toothpaste and preparation method thereof.
The whitening stain removing toothpaste that the present invention is provided can effectively remove color stain, dental plaque, such as cigarette stain, tea stain, coffee stain, bacterial plaque etc., beautiful
White tooth, it is to avoid tooth turns yellow, it is non-toxic, it is non-stimulated to oral mucosa, stain can be effectively cleaned, enamel will not be made again
Into destruction, bacteria breed, fresh breath are persistently resisted in full effect nursing oral cavity.
The technical scheme is that：
A kind of whitening stain removing toothpaste, including following components and its parts by weight：
Propane diols 6-9 parts, sorbierite 8-10 parts, silica 1 8-24 parts, calcium pyrophosphate 26-30 parts, peppermint oil 0.4-
0.8 part, saccharin sodium 0.02-0.06 parts, propylben 0.1-0.3 parts, Cocoamidopropyl betaine 0.5-1.6 parts, xanthan
Glue 0.3-1.2 parts, xylitol 0.03-0.08 parts, methyl p-hydroxybenzoate 0.05-0.12 parts, tea tree ethereal oil 0.2-0.5 parts,
Perlite 3-5 parts, Fructus Chaenomelis ferment 0.8-1.6 parts, stannous pyrophosphate 1-2 parts, sodium alginate 0.5-1 parts and deionized water 14-25
Part.
Further, the whitening stain removing toothpaste includes following components and its parts by weight：
8 parts of propane diols, 9 parts of sorbierite, 22 parts of silica, 28 parts of calcium pyrophosphate, 0.5 part of peppermint oil, saccharin sodium 0.04
Part, 0.2 part of propylben, 0.8 part of Cocoamidopropyl betaine, 0.5 part of xanthans, 0.06 part of xylitol, para hydroxybenzene
0.08 part of methyl formate, 0.4 part of tea tree ethereal oil, 4 parts of perlite, 1.2 parts of Fructus Chaenomelis ferment, 1.5 parts of stannous pyrophosphate, sodium alginate
0.7 part and 18 parts of deionized water.
In addition, present invention also offers the preparation method of the whitening stain removing toothpaste, comprising the following steps：
S1 takes saccharin sodium, Cocoamidopropyl betaine, xylitol, xanthans and sodium alginate, is added to deionized water
In, water proof is heated to 65-75 DEG C, and constant temperature is stirred to being completely dissolved, and obtains mixed liquor；
To propane diols and sorbierite is added in step S1 gained mixed liquors, mixing time is 15-22 minutes, time of repose to S2
It is 2-4 hours, obtains mixture I；
S3 takes silica, calcium pyrophosphate, propylben, methyl p-hydroxybenzoate, perlite and stannous pyrophosphate,
Stir, obtain mixture II；
To step S3 gained mixtures II are added in step S2 gained mixtures I, mixing speed is 500-600r/min to S4,
Mixing time is 50-80 minutes, obtains mixture III；
S5 in step S4 gained mixtures III to peppermint oil, tea tree ethereal oil and Fructus Chaenomelis ferment is added, and high-speed stirred, stirring is fast
It is 1500-2000r/min to spend, and mixing time is 12-20 minutes, and degassing is obtained final product.
Further, the step S1 water proofs are heated to 70 DEG C.
Further, the step S2 mixings time are 18 minutes.
Further, the step S2 time of repose is 3 hours.
Further, the step S4 mixing speeds are 580r/min.
Further, the step S4 mixings time are 70 minutes.
Further, the step S5 mixing speeds are 1800r/min.
Further, the step S5 mixings time are 16 minutes.
The effect of primary raw material used in the present invention：
Calcium pyrophosphate：No. CAS：7790-76-3, molecular formula：Ca2O7P2, molecular weight：254.10.Purposes：Food industry is used
Make nutritional supplement, yeast nutriment, buffer, nertralizer.Can be additionally used in dentifrice abrasives, paint filler, electrotechnical apparatus fluorophor.
Toothpaste abrasives are also acted as, the toothpaste with fluoride that the power that cleans the teeth is strong, smooth appearance is fine and smooth is can be made into.
Peppermint oil：No. CAS：68917-18-0.Purposes：It is mainly used in dental health article, such as toothpaste, tooth powder, and at certain
It is used as the medicament of refrigerant, wind dispelling, anti-inflammatory, analgesia and excitement in a little medicines.Articles for use, some cosmetics, tobacco and food after shaving
Also be can be used in product.
Saccharin sodium：No. CAS：6155-57-3, molecular formula：C6H4SO2NNaCO·2H2O, molecular weight：241.2.Purposes：Raise
Feed additives：Pig feed, fragrant and sweet dose etc.；Daily use chemicals industry：Toothpaste, mouthwash, eyedrops etc..
Propylben：No. CAS：94-13-3, molecular formula：C10H12O3, molecular weight：180.2005.Main application：It is used as
The preservative of food, cosmetics, medicine etc., antioxidant, bactericide.
Cocoamidopropyl betaine：No. CAS：86438-79-1, molecular formula：C19H38N2O3, molecular weight：342.52.Coconut palm
Oleamide CAB is a kind of zwitterionic surfactant, and excellent stabilization is respectively provided with acid and alkalescence condition
Property, soluble in water, to ph stability, foam is more, strong detergency, with excellent thickening property, flexibility, bactericidal properties, antistatic
Property, hard water resistance property.
Xanthans：No. CAS：11138-66-2, molecular formula：C35H49O2.Xanthans is fermented through Xanthomonas campestris by carbohydrate,
The extracellular microbial polysaccharide for producing.Due to its macromolecular special construction and colloid property, and there are various functions, can be used as breast
Agent, stabilizer, gelling thickener, size, film forming agent etc..
Xylitol：No. CAS：87-99-0, molecular formula：C5H12O5, molecular weight：152.15.Xylitol can as sweetener,
With preventing caries function.
P-hydroxybenzoate：No. CAS：99-76-3, molecular formula：C8H8O3, molecular weight：152.15.P-hydroxybenzoic acid
Ester is a kind of preservative in cosmetics, medicine, can be also used in food additives sometimes.
Tea tree ethereal oil：No. CAS：68647-73-4.Tea tree ethereal oil is from port wood Myrtaceae cajeputtree in the way of distilling
The Pure natural plant essential oil extracted in leaf.With antibacterial, anti-inflammatory, expelling parasite, the effects such as mite killing.
Perlite：No. CAS：93763-70-3.Perlite can be used in toothpaste as rubbing agent, the raw material sheet of toothpaste level
Body whole process is the physical refining process of pure green, and the raw material that neutral pH and chemical inertness also complies with dental products will
Ask.
Fructus Chaenomelis ferment：No. CAS：9001-73-4, molecular formula：C19H29N7O6, molecular weight：451.47686.Fructus Chaenomelis ferment is
It is present in a kind of proteolytic enzyme in pawpaw, is to maintain the life such as body normal function, digestion food, repair tissue to live
A kind of dynamic required material.Fructus Chaenomelis ferment can be helped digest, absorbed, can be with this three big battalion of decomposing protein, carbohydrate and fat
The plant of element is supported, especially clear stool expelling intestinal toxin and decomposition waist and belly fat effect is significant, this is the major function of Fructus Chaenomelis ferment.
Stannous pyrophosphate：No. CAS：15578-26-4, molecular formula：Sn2P2O7, molecular weight：411.32.For tin plating, toothpaste
Filler, refines potter's clay, improves paint performance.
Sodium alginate：No. CAS：9005-38-3.Sodium alginate is a kind of natural polysaccharide, with needed for pharmaceutical preparation auxiliary material
Stability, dissolubility, viscosity and security.Purposes：With used as stabilizers, thickener, emulsifying agent, dispersant, gelling agent, envelope
Agent, suspending agent etc..
The whitening stain removing toothpaste that the present invention is provided is made by propane diols, sorbierite, silica, calcium pyrophosphate and peppermint oil etc.
It is standby to form.In whitening stain removing toothpaste of the present invention, propane diols and sorbierite are played and slow down waving for moisture in formula as NMF
Hair, improves lotion and dries the effect of the degree being hardened and the freezing point for reducing lotion, in addition, the effect of solubilising can also be played, improves
The stability of the product of preparation.In whitening stain removing toothpaste of the present invention, silica, calcium pyrophosphate and perlite are mainly used as tooth
The rubbing agent of cream, with other compositions of the present invention synergy, plays the effect of stain whitening.In whitening stain removing toothpaste of the present invention
In, saccharin sodium is used as sweetener, and saccharin sodium is water-soluble good, will not cause the problem of toothpaste stability.Gone in whitening of the present invention
In stain toothpaste, propylben and methyl p-hydroxybenzoate are used as preservative.In whitening stain removing toothpaste of the present invention, cocounut oil acyl
Amine CAB is zwitterionic surfactant, it with whitening stain removing toothpaste of the present invention in other compositions have it is good
Compatibility, can using toothpaste when the foam that produces it is finer and smoother, that improves product goes stain ability.Stain tooth is removed in whitening of the present invention
In cream, xanthans and sodium alginate are used as adhesive, the powder such as the rubbing agent in toothpaste is combined into colloid with liquid component, make
The lotion that must be prepared has good rheological characteristic.In whitening stain removing toothpaste of the present invention, xylitol is used as sweetener, in addition,
Other compositions synergy with the present invention, has efficient inhibitory action to pernicious bacteria in oral cavity, can effectively suppress bacterium
The formation of spot.In whitening stain removing toothpaste of the present invention, stannous pyrophosphate is mainly used as the filler of toothpaste.Gone in whitening of the present invention
In stain toothpaste, peppermint oil and tea tree ethereal oil can be supplied to the unique fragrance of toothpaste and mouthfeel, cover the disagreeable taste of raw material, assign
Give the sensation of oral cavity fresh and cool, in addition, with other raw material collective effects, the effect with sterilization and anticorrosion anti-inflammatory.In whitening of the present invention
In stain removing toothpaste, Fructus Chaenomelis ferment is a kind of proteolytic enzyme being present in pawpaw, is to maintain body normal function, digestion
A kind of required material of the vital movements such as food, repair tissue, it can act synergistically with the other compositions in the present invention, can be effective
Tooth stain is decomposed, prevents bacterial plaque from producing, brilliant white tooth.
The whitening stain removing toothpaste formula that the present invention is provided is reasonable, using safety, will not produce stimulation to oral mucosa, passes through
The synergy of various composition, can effectively remove color stain and dental plaque, without damaging enamel and dentine, can entirely imitate nursing
Oral cavity, persistently resists bacteria breed, fresh breath, with significant whitening stain-removing effect.
Compared with prior art, the whitening stain removing toothpaste that the present invention is provided has the advantage that：
(1) the whitening stain removing toothpaste that the present invention is provided has comfortable fragrance and taste, there is cool and sweet-smelling sensation after use.
(2) the whitening stain removing toothpaste that the present invention is provided is non-toxic, non-stimulated to oral mucosa.
(3) the whitening stain removing toothpaste that the present invention is provided can effectively remove color stain, dental plaque, such as cigarette stain, tea stain, coffee stain,
Bacterial plaque etc., tooth-whitening, it is to avoid tooth turns yellow.
(4) the whitening stain removing toothpaste that the present invention is provided can effectively remove color stain and dental plaque, without damaging enamel and tooth
Essence, can entirely imitate nursing oral cavity, persistently resist bacteria breed, fresh breath.
Specific embodiment
Below by way of the description of specific embodiment, the invention will be further described, but this is not to limit of the invention
System, those skilled in the art's basic thought of the invention, various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
Embodiment 1, a kind of whitening stain removing toothpaste
The whitening stain removing toothpaste is made up of (every part is 1000g) following components and its parts by weight：
6 parts of propane diols, 8 parts of sorbierite, 8 parts of silica 1,26 parts of calcium pyrophosphate, 0.4 part of peppermint oil, saccharin sodium 0.02
Part, 0.1 part of propylben, 0.5 part of Cocoamidopropyl betaine, 0.3 part of xanthans, 0.03 part of xylitol, para hydroxybenzene
0.05 part of methyl formate, 0.2 part of tea tree ethereal oil, 3 parts of perlite, 0.8 part of Fructus Chaenomelis ferment, 1 part of stannous pyrophosphate, sodium alginate
0.5 part and 14 parts of deionized water.
Preparation method：
S1 takes saccharin sodium, Cocoamidopropyl betaine, xylitol, xanthans and sodium alginate, is added to deionized water
In, water proof is heated to 65 DEG C, and constant temperature is stirred to being completely dissolved, and obtains mixed liquor；
To propane diols and sorbierite is added in step S1 gained mixed liquors, mixing time is 15 minutes to S2, and time of repose is 2
Hour, obtain mixture I；
S3 takes silica, calcium pyrophosphate, propylben, methyl p-hydroxybenzoate, perlite and stannous pyrophosphate,
Stir, obtain mixture II；
To step S3 gained mixtures II are added in step S2 gained mixtures I, mixing speed is 500r/min to S4, stirring
Time is 50 minutes, obtains mixture III；
S5 in step S4 gained mixtures III to peppermint oil, tea tree ethereal oil and Fructus Chaenomelis ferment is added, and high-speed stirred, stirring is fast
It is 1500r/min to spend, and mixing time is 12 minutes, and degassing is obtained final product.
Embodiment 2, a kind of whitening stain removing toothpaste
The whitening stain removing toothpaste is made up of (every part is 1000g) following components and its parts by weight：
9 parts of propane diols, 10 parts of sorbierite, 24 parts of silica, 30 parts of calcium pyrophosphate, 0.8 part of peppermint oil, saccharin sodium 0.06
Part, 0.3 part of propylben, 1.6 parts of Cocoamidopropyl betaine, 1.2 parts of xanthans, 0.08 part of xylitol, para hydroxybenzene
0.12 part of methyl formate, 0.5 part of tea tree ethereal oil, 5 parts of perlite, 1.6 parts of Fructus Chaenomelis ferment, 2 parts of stannous pyrophosphate, sodium alginate 1
25 parts of part and deionized water.
Preparation method：
S1 takes saccharin sodium, Cocoamidopropyl betaine, xylitol, xanthans and sodium alginate, is added to deionized water
In, water proof is heated to 75 DEG C, and constant temperature is stirred to being completely dissolved, and obtains mixed liquor；
To propane diols and sorbierite is added in step S1 gained mixed liquors, mixing time is 22 minutes to S2, and time of repose is 4
Hour, obtain mixture I；
S3 takes silica, calcium pyrophosphate, propylben, methyl p-hydroxybenzoate, perlite and stannous pyrophosphate,
Stir, obtain mixture II；
To step S3 gained mixtures II are added in step S2 gained mixtures I, mixing speed is 600r/min to S4, stirring
Time is 80 minutes, obtains mixture III；
S5 in step S4 gained mixtures III to peppermint oil, tea tree ethereal oil and Fructus Chaenomelis ferment is added, and high-speed stirred, stirring is fast
It is 2000r/min to spend, and mixing time is 20 minutes, and degassing is obtained final product.
Embodiment 3, a kind of whitening stain removing toothpaste
The whitening stain removing toothpaste is made up of (every part is 1000g) following components and its parts by weight：
8 parts of propane diols, 9 parts of sorbierite, 22 parts of silica, 28 parts of calcium pyrophosphate, 0.5 part of peppermint oil, saccharin sodium 0.04
Part, 0.2 part of propylben, 0.8 part of Cocoamidopropyl betaine, 0.5 part of xanthans, 0.06 part of xylitol, para hydroxybenzene
0.08 part of methyl formate, 0.4 part of tea tree ethereal oil, 4 parts of perlite, 1.2 parts of Fructus Chaenomelis ferment, 1.5 parts of stannous pyrophosphate, sodium alginate
0.7 part and 18 parts of deionized water.
Preparation method：
S1 takes saccharin sodium, Cocoamidopropyl betaine, xylitol, xanthans and sodium alginate, is added to deionized water
In, water proof is heated to 70 DEG C, and constant temperature is stirred to being completely dissolved, and obtains mixed liquor；
To propane diols and sorbierite is added in step S1 gained mixed liquors, mixing time is 18 minutes to S2, and time of repose is 3
Hour, obtain mixture I；
S3 takes silica, calcium pyrophosphate, propylben, methyl p-hydroxybenzoate, perlite and stannous pyrophosphate,
Stir, obtain mixture II；
To step S3 gained mixtures II are added in step S2 gained mixtures I, mixing speed is 580r/min to S4, stirring
Time is 70 minutes, obtains mixture III；
S5 in step S4 gained mixtures III to peppermint oil, tea tree ethereal oil and Fructus Chaenomelis ferment is added, and high-speed stirred, stirring is fast
It is 1800r/min to spend, and mixing time is 16 minutes, and degassing is obtained final product.
Comparative example 1, a kind of whitening stain removing toothpaste
The whitening stain removing toothpaste is made up of (every part is 1000g) following components and its parts by weight：
8 parts of propane diols, 9 parts of sorbierite, 22.5 parts of silica, 28.2 parts of calcium pyrophosphate, 0.5 part of peppermint oil, saccharin sodium
0.04 part, 0.2 part of propylben, 0.8 part of Cocoamidopropyl betaine, 0.5 part of xanthans, 0.06 part of xylitol, to hydroxyl
0.08 part of yl benzoic acid methyl esters, 0.4 part of tea tree ethereal oil, 4.5 parts of perlite, 1.5 parts of stannous pyrophosphate, 0.7 part of sodium alginate and
18 parts of deionized water.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, without addition Fructus Chaenomelis ferment, to increase silica, calcium pyrophosphate and perlite
Parts by weight.
Comparative example 2, a kind of whitening stain removing toothpaste
The whitening stain removing toothpaste is made up of (every part is 1000g) following components and its parts by weight：
8 parts of propane diols, 9 parts of sorbierite, 22 parts of silica, 28 parts of calcium pyrophosphate, 0.5 part of peppermint oil, saccharin sodium 0.04
Part, 0.2 part of propylben, 0.8 part of Cocoamidopropyl betaine, 0.5 part of xanthans, 0.06 part of xylitol, para hydroxybenzene
0.08 part of methyl formate, 0.4 part of tea tree ethereal oil, 4 parts of perlite, 1.2 parts of Bromelain, 1.5 parts of stannous pyrophosphate, sodium alginate
0.7 part and 18 parts of deionized water.
Preparation method is similar to Example 3.
Difference with embodiment 3 is that Fructus Chaenomelis ferment is replaced with into Bromelain.
Test example one, the health of whitening stain removing toothpaste, sense organ and physical and chemical index performance test
1st, test material：Stain tooth is removed in whitening prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2
Cream.
2nd, test method：With reference to National Standard of the People's Republic of China GB8372-2008《Toothpaste》Relevant criterion, test
The sanitary index of whitening stain removing toothpaste prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2, sense organ and reason
Change index.
3rd, result of the test：
As shown in table 1, sense organ and physical and chemical index assay are as shown in table 2 for sanitary index assay.
Table 1：Whitening stain removing toothpaste sanitary index assay
As shown in Table 1, the whitening stain removing toothpaste that prepared by embodiment of the present invention 1-3 and comparative example 1 and comparative example 2 is defended
Raw index test result is qualified, and better than national standard.
Table 2：The sense organ of whitening stain removing toothpaste, physical and chemical index assay
As shown in Table 2, the sense of whitening stain removing toothpaste prepared by embodiment of the present invention 1-3 and comparative example 1 and comparative example 2
Official, physical and chemical index assay meet GB8372-2008《Toothpaste》Relevant criterion.
Test example two, the whitening stain-removing effect of whitening stain removing toothpaste
1st, test material：Stain tooth is removed in whitening prepared by embodiment 1, embodiment 2, embodiment 3, comparative example 1 and comparative example 2
Cream.
2nd, subjects：Choose 210 subjects and participate in experiment, subject includes and exclusion standard：Subject is symbol
Conjunction include and exclusion standard NAM and women.Inclusive criteria：(1) age 18-62 Sui；(2) subject is custom
Property smoker；(3) whole body health is in order；(4) inspection can at any time be participated in during 8 weeks of experiment；(5) it is intraoral to have 11 days
Right labial teeth；(6) dental exogenous mottle index and >=25.Exclusion standard：(1) having more than 5 needs the activity dental caries for the treatment of to damage；
(2) subject has late period periodontal disease；(3) tooth has endogenous pigment influence dna exogenous pigment evaluation；(4) women is in gestation
Or nursing period；(5) other clinical tests are just being participated at present；(6) orthodontic treatment is being carried out or with removable partial denture.
Subject is randomly divided into five groups, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and comparative example 2
Group, every group of 42 people.2 groups of 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 1 group of comparative example and comparative example use the present invention respectively
Whitening stain removing toothpaste prepared by embodiment 1-3 and comparative example 1-2, it is sooner or later each with once, it is continuous to use 8 weeks.Five groups of subjects
At aspects such as sex, ages, there was no significant difference, and recipient site does not use other toothpaste during experiment.
3rd, test method：
Baseline is checked：Inspection including medical history inquiry, examination of mouth and the coloring of upper mandibular anterior teeth.Teeth stains are used
Lobene color spot indexes are evaluated, and classification score is 0-3 points, and the different area and dye levels at color spot position are represented respectively,
As shown in table 3.
Table 3：The classification score of Lobene color spots index
| Classification score | Area | Degree |
| 0 | Exist without color spot | Exist without color spot |
| 1 | The 1/3 of color spot area≤facing | Slight color spot (yellow or yellowish-brown) |
| 2 | The 2/3 of color spot area≤facing | Moderate color spot (moderate brown) |
| 3 | The 2/3 of color spot area ＞ facings | Severe color spot (dark-brown or black) |
Check that tooth position is the labial surface of the lip, lingual surface and premanillary teeth of mandibular anterior teeth.Each facing is divided into two score areas：Tooth
Vitrea eye and Ya Ti areas.The average color spot score mean of each subject is divided into area score mean and degree score mean：Color spot
Area score mean is the color spot area score sum of each facing divided by total inspection facing number, degree score mean calculating side
Method is identical with the color spot area equal number calculating method of score.Each group baseline and after the 4th, 8 weeks Lobene color spot area indexs compare as
Shown in table 4, each group baseline and Lobene color spot extent indexs are more as shown in table 5 after the 4th, 8 weeks.
Table 4：Each group baseline and Lobene color spot area indexs compare after the 4th, 8 weeks
As can be seen from Table 4, when testing the 4th week, the implementation of the whitening stain removing toothpaste prepared using embodiment of the present invention 1-3
The color spot area index of 3 groups of 1 group of example, 2 groups of embodiment and embodiment reduces 17.6%, 18.53% and 20% respectively, and uses
1 group of the comparative example of whitening stain removing toothpaste and the color spot area index of 2 groups of comparative example prepared by comparative example 1 and comparative example 2 drops respectively
It is low by 6.84% and 7.33%.When testing the 8th week, the embodiment 1 of the whitening stain removing toothpaste prepared using embodiment of the present invention 1-3
The color spot area index of 3 groups of group, 2 groups of embodiment and embodiment reduces 36.91%, 37.5% and 39.57% respectively, and uses
The color spot area index point of 2 groups of preparations of 1 group of comparative example and comparative example of whitening stain removing toothpaste prepared by comparative example 1 and comparative example 2
17.52% and 17.67% is not reduced.
Table 5：Each group baseline and Lobene color spot extent indexs compare after the 4th, 8 weeks
As can be seen from Table 5, when testing the 4th week, the implementation of the whitening stain removing toothpaste prepared using embodiment of the present invention 1-3
The color spot extent index of 3 groups of 1 group of example, 2 groups of embodiment and embodiment reduces 16.98%, 17.21% and 18.06% respectively, and
1 group of the comparative example of the whitening stain removing toothpaste prepared using comparative example 1 and comparative example 2 and the color spot extent index point of 2 groups of comparative example
7.01% and 8.92% is not reduced.When testing the 8th week, the reality of the whitening stain removing toothpaste prepared using embodiment of the present invention 1-3
The color spot extent index for applying 3 groups of 1 group of example, 2 groups of embodiment and embodiment reduces 34.43%, 34.88% and 36.11% respectively,
And use 1 group of the comparative example and the color spot extent index of 2 groups of comparative example of comparative example 1 and the whitening stain removing toothpaste of the preparation of comparative example 2
15.42% and 16.43% is reduced respectively.
Can be drawn by table 4 and table 5, compared with whitening stain removing toothpaste prepared by comparative example 1 and comparative example 2, using this hair
Whitening stain removing toothpaste prepared by bright embodiment 1-3 is brushed teeth twice daily, the area and journey of the exogenous color spot of facing after 4 weeks and 8 weeks
Degree index is significantly reduced.This explanation, whitening stain removing toothpaste prepared by the present invention has significantly removes stain whitening effect.
Claims (10)
1. a kind of whitening stain removing toothpaste, it is characterised in that including following components and its parts by weight：
Propane diols 6-9 parts, sorbierite 8-10 parts, silica 1 8-24 parts, calcium pyrophosphate 26-30 parts, peppermint oil 0.4-0.8 parts,
Saccharin sodium 0.02-0.06 parts, propylben 0.1-0.3 parts, Cocoamidopropyl betaine 0.5-1.6 parts, xanthans 0.3-
1.2 parts, xylitol 0.03-0.08 parts, methyl p-hydroxybenzoate 0.05-0.12 parts, tea tree ethereal oil 0.2-0.5 parts, perlite
3-5 parts, Fructus Chaenomelis ferment 0.8-1.6 parts, stannous pyrophosphate 1-2 parts, sodium alginate 0.5-1 parts and deionized water 14-25 parts.
2. whitening stain removing toothpaste as claimed in claim 1, it is characterised in that including following components and its parts by weight：
8 parts of propane diols, 9 parts of sorbierite, 22 parts of silica, 28 parts of calcium pyrophosphate, 0.5 part of peppermint oil, 0.04 part of saccharin sodium, Buddhist nun
Golden 0.2 part of the propyl ester of pool, 0.8 part of Cocoamidopropyl betaine, 0.5 part of xanthans, 0.06 part of xylitol, P-hydroxybenzoic acid first
0.08 part of ester, 0.4 part of tea tree ethereal oil, 4 parts of perlite, 1.2 parts of Fructus Chaenomelis ferment, 1.5 parts of stannous pyrophosphate, 0.7 part of sodium alginate
With 18 parts of deionized water.
3. the preparation method of whitening stain removing toothpaste as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
S1 takes saccharin sodium, Cocoamidopropyl betaine, xylitol, xanthans and sodium alginate, is added in deionized water, every
Water is heated to 65-75 DEG C, and constant temperature is stirred to being completely dissolved, and obtains mixed liquor；
To propane diols and sorbierite is added in step S1 gained mixed liquors, mixing time is 15-22 minutes to S2, and time of repose is 2-
4 hours, obtain mixture I；
S3 takes silica, calcium pyrophosphate, propylben, methyl p-hydroxybenzoate, perlite and stannous pyrophosphate, stirring
Uniformly, mixture II is obtained；
To step S3 gained mixtures II are added in step S2 gained mixtures I, mixing speed is 500-600r/min to S4, stirring
Time is 50-80 minutes, obtains mixture III；
To peppermint oil, tea tree ethereal oil and Fructus Chaenomelis ferment, high-speed stirred is added in step S4 gained mixtures III, mixing speed is S5
1500-2000r/min, mixing time is 12-20 minutes, and degassing is obtained final product.
4. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S1 water proofs are heated to
70℃。
5. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S2 mixings time are
18 minutes.
6. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S2 time of repose is
3 hours.
7. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S4 mixing speeds are
580r/min。
8. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S4 mixings time are
70 minutes.
9. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S5 mixing speeds are
1800r/min。
10. the preparation method of whitening stain removing toothpaste as claimed in claim 3, it is characterised in that the step S5 mixings time
It is 16 minutes.
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| CN107320368A (en) * | 2017-06-23 | 2017-11-07 | 广州暨南生物医药研究开发基地有限公司 | A kind of adult's toothpaste of the ash containing Chinese mugwort and preparation method thereof |
| CN107693413A (en) * | 2017-09-27 | 2018-02-16 | 浙江海洋大学 | It is a kind of to add the green algae polysaccharide additive in toothpaste |
| CN107714502A (en) * | 2017-10-11 | 2018-02-23 | 苏州市金茂日用化学品有限公司 | A kind of stain removing toothpaste of containing diatomite |
| CN109498542A (en) * | 2018-12-29 | 2019-03-22 | 泰州优克生物科技有限公司 | A kind of biological toothpaste for anti-helicobacter pylori |
| CN109568185A (en) * | 2019-01-10 | 2019-04-05 | 德利宝(广州)香料有限公司 | A kind of dentifrice composition and preparation method thereof containing tea oil compounding menthol essence |
| CN112716851A (en) * | 2021-01-15 | 2021-04-30 | 江苏福砳生物环保科技有限公司 | Halitosis-removing health toothpaste containing zeolite and preparation method thereof |
| CN113244121A (en) * | 2021-07-01 | 2021-08-13 | 苏州工业园区方津口腔诊所有限公司 | Whitening antibacterial toothpaste |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107320368A (en) * | 2017-06-23 | 2017-11-07 | 广州暨南生物医药研究开发基地有限公司 | A kind of adult's toothpaste of the ash containing Chinese mugwort and preparation method thereof |
| CN107693413A (en) * | 2017-09-27 | 2018-02-16 | 浙江海洋大学 | It is a kind of to add the green algae polysaccharide additive in toothpaste |
| US11547118B1 (en) * | 2017-10-03 | 2023-01-10 | Elbert Lawrence | Natural pesticides, substances and methods of fabrication thereof |
| CN107714502A (en) * | 2017-10-11 | 2018-02-23 | 苏州市金茂日用化学品有限公司 | A kind of stain removing toothpaste of containing diatomite |
| CN109498542A (en) * | 2018-12-29 | 2019-03-22 | 泰州优克生物科技有限公司 | A kind of biological toothpaste for anti-helicobacter pylori |
| CN109568185A (en) * | 2019-01-10 | 2019-04-05 | 德利宝(广州)香料有限公司 | A kind of dentifrice composition and preparation method thereof containing tea oil compounding menthol essence |
| CN112716851A (en) * | 2021-01-15 | 2021-04-30 | 江苏福砳生物环保科技有限公司 | Halitosis-removing health toothpaste containing zeolite and preparation method thereof |
| CN113244121A (en) * | 2021-07-01 | 2021-08-13 | 苏州工业园区方津口腔诊所有限公司 | Whitening antibacterial toothpaste |
| CN113679625A (en) * | 2021-08-11 | 2021-11-23 | 上海驻净电子科技有限公司 | Oral care agent with lasting fragrance |
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Application publication date: 20170531 |