RU2355379C1 - Therapeutic-preventive dentifrice water and method for making thereof - Google Patents

Abstract

FIELD: medicine; dentistry.

SUBSTANCE: therapeutic-preventive dentifrice water containing glycerine, extracts of garden sage leaves, eucalyptus leaves, sweetbrier hips, globe thistle fruits, penny-mountain herb, cranberry high bark, as well as aromatiser, dye and aerated mineral water "Kislovodsky Narzan" in certain ratio.

EFFECT: dentifrice water promotes effective oral cavity pH recovery, ensures antiinflammatory, keratoplasty and remineralising action.

2 tbl, 2 ex

Description

The invention relates to dentistry, namely to means for the care of teeth, oral cavity and mouthwash.

Dental elixirs are convenient to use, have no contraindications, quickly give a cleansing, deodorizing and refreshing effect, have anti-inflammatory properties. Dental elixirs are indispensable for hygienic oral care for tooth decay, gingivitis, periodontitis. The composition of dental elixirs includes substances of plant origin, as well as chemical compounds and enzymes. Depending on the type of useful additives introduced into the composition of the elixir and their properties, elixirs can be hygienic and therapeutic.

To rinse the oral cavity, decoctions and infusions from plant materials, such as oak bark, sage leaves, eucalyptus, chamomile flowers, marigold, St. John's wort and other plants, are widely used [1]. Known tool based on calendula for the treatment and prevention of gingivitis and periodontitis. This tool is an aqueous infusion (10 g of calendula flowers per 1 cup of boiling water) or tincture (1 teaspoon per 1 cup of warm water). The disadvantage of this tool is that it is monocomponent, therefore, does not have a wide range of therapeutic effects and is ineffective in inflammatory diseases of the oral cavity [2].

A known composition for the prevention and treatment of diseases of the oral cavity and care for teeth and oral cavity (RF patent No. 2180555, A61K 7/26, 2000). This composition is an aqueous extract of herbs of chamomile pharmacy, Hypericum perforatum, dried marshmallow, Echinacea purpurea, medicinal sage leaves, common oak bark, and calamus swamp. The disadvantage of this tool is the low antibacterial and anti-inflammatory effect.

Known dental elixir, as the main active ingredients containing vitamin B ₁ and sodium fluoride, which has high cleaning, deodorizing and antimicrobial properties [3]. Elixir is recommended as a hygiene product that helps to reduce the amount of dental deposits, reduce the intensity of dental caries and gum disease. It is used in the form of mouth rinses with an elixir aqueous solution at the rate of 20 drops per 0.5 cup of water 2-3 times a day.

The disadvantage of the composition of this elixir is insufficient strengthening and anti-inflammatory effect of the drug, the main emphasis is on deodorizing quality, while there is no effective effect on periodontal tissue. This composition does not eliminate inflammation in the periodontal pockets and does not have sufficient penetration in the periodontal tissue and the mucous membrane of the oral cavity.

Known tools: dental elixir "Forest" containing chlorophyll-carotene mixture, which has a deodorizing and cleansing effect, dental elixir "Eucalyptus" containing biologically active substances of plant origin (St. John's wort, pine buds, eucalyptus), which has tanning, astringent and antimicrobial properties fatally acting on fungi of the genus Candida, lemon elixir, containing 40% formalin and borax as active components, fatal on fungal flora and streptococci, oblast giving pronounced cleansing properties [3].

The disadvantage of these oral hygiene products is that they have insufficient strengthening and anti-inflammatory effects on periodontal tissues, do not have keratoplastic properties, and also do not eliminate the symptoms of inflammation in periodontal pockets, especially during severe purulent inflammation with gingivitis and periodontitis. In addition, the composition and formulation of these hygiene products does not provide for an effect on the pH of the oral cavity.

Known dental elixir containing ethyl alcohol, polyhydric alcohol, extracts of plant materials, essential oils, flavoring and drinking water (RF patent No. 20111376, A61K 7/16, 1994). The disadvantage of this tool is the lack of anti-inflammatory, anti-carious and remineralizing properties, since the pH of this tool does not provide the desired acid-base balance in the oral cavity.

The closest in technical essence and the achieved positive effect and adopted by us for the prototype is “Dental Elixir” (RF patent No. 2263499, А61К 7/16, 7/26 11/10/2004), which contributes to the rapid restoration of acidified pH, which allows to increase anti-inflammatory, anti-caries and remineralizing properties containing ethyl alcohol, polyhydric alcohol, rebaudioside A, extracts of marsh cinquefoil, stevia leaves, garden turnip leaves, cerapadus leaves, aspen bark, tea tree and myrrh essential oils, lignans from lignans holding the plants, selenocysteine and drinking water.

The disadvantage of this drug is that rebaudioside A, introduced as a flavoring additive to stabilize the acid-base balance and as a factor preventing oral acidification, effective in tooth decay, is not effective in periodontitis and gingivitis. With prolonged use, it is a factor in an additional decrease in the pH of the oral cavity, activation of microorganisms, their fixation on tooth enamel and periodontal tissues and the formation of dental plaque. In addition, when using this elixir containing ethyl alcohol, introduced as a solvent and preservative, dental dentin hypersensitivity may occur, especially in patients with gum recession and periodontopathy.

The problem solved by this invention is an effective, long-term restoration of the pH of the oral cavity and increase the anti-inflammatory, keratoplastic and remineralizing effects of the dental elixir without the use of ethyl alcohol using available components and a fairly simple technology.

The problem is solved by introducing into the composition of a therapeutic and preventive dental elixir containing polyhydric alcohol - glycerin, extracts of plant materials, extracts of sage leaves, eucalyptus, cinnamon rose hips, common mordovia, creeping thyme grass, common viburnum bark, and also fragrance, carbonated mineral dye and water "Kislovodsk Narzan", with the following ratio of components, wt.%:

glycerol 10-15 sage leaf extract 4-8 eucalyptus leaf extract 3-5 cinnamon rose hips extract 4-8 common muzzle fruit extract 3-5 creeping thyme herb extract 4-8 Viburnum bark extract 4-8 perfume 0.1-0.2 dye 0.001-0.002 sparkling mineral water Kislovodsk Narzan rest

The parameters of the components introduced into the composition of the tooth elixir were determined empirically. The introduction of components below the lower or higher than the upper limit does not provide optimal exposure, and also worsens the presentation of the elixir.

Characterization of the components of the tooth elixir.

Polyhydric alcohol (glycerin) has a stabilizing effect, softens and fixes the composition.

The extract of sage leaves due to the content of essential oil, tannins and phytoncides has an anti-inflammatory, astringent and disinfecting effect.

The extract of eucalyptus leaves contains a high (up to 3%) amount of essential oils and tannins [4], as well as organic acids and has a bactericidal effect, in addition it has a pleasant and persistent smell.

The main advantage of the rosehip extract is a rich set of vitamins (ascorbic acid, riboflavin, vitamins K, P, E, carotene), which have a pronounced antioxidant effect. They contain a lot of tannins. The extract has antimicrobial, astringent, anti-inflammatory and hemostatic effects.

The extract of the fruit of the common muzzle has a general tonic effect, increases the permeability of the oral mucosa and promotes a deeper penetration of drugs into the periodontal tissue, tones the circular ligament of the tooth.

Creeping thyme herb extract contains many essential oils, tannins, flavonoids, ursolic and oleic acids. The extract from this plant has a strong anti-inflammatory effect (due to the content of thymol), as well as an analgesic and wound healing effect.

Viburnum bark extract contains Vitamin K ₁ (28-31 mg / 100 g), ascorbic acid (70-80 mg / 100 g) and carotenes (up to 21 mg / 100 g), tannins (up to 2%) [4] , has a keratoplastic effect, prevents ulceration of the oral mucosa, bleeding of the gums and periodontal tissues.

Fragrance - as fragrance taken is the natural flavoring food "Strawberry", with the aroma of fresh strawberries. It is possible to use “Green Apple” food flavoring as a fragrance.

Dye - food red (cochineal), liquid. Dye of red "strawberry" color. With a minimum dosage, the color of ripe strawberries is obtained, and with a large dosage, a bright flame. It is also possible to use the food coloring “Green Apple” - a water-soluble green dye powder.

The basis of the product is mineral water “Kislovodsk Narzan” due to the contained carbon dioxide (CO ₂ ) expands the capillaries of the oral mucosa and helps to saturate the periodontal tissues with oxygen, providing stabilization of the active medicinal phytocomponents both on the surface of the mucous membrane and in its deeper layers .

Mineral sparkling water “Kislovodsk Narzan” (section of the Kislovodsk deposit, wells 5/0 and 5/0 bis) complies with GOST 13273-88 and is sulphate-bicarbonate magnesium-calcium and sodium-magnesium-calcium with a mineralization level of 2.0-3 , 0, helps to remineralize tooth enamel, strengthen bone tissue, maintain a slightly acidic pH and increase the alkaline environment for a sufficiently long period of time (pH 6.9-7.9) after eating and rinsing with elixir (up to 1.5 hours).

The tooth elixir is a uniform clear liquid, from straw yellow to light brown and brown in color, with a pleasant herbal, spicy odor and fresh taste with a pH of 6.9-7.9.

The elixir is used as follows: 30-40 drops or 1 tablespoon in 1/3 cup of warm water. Rinse intensively for 5-7 minutes after each meal, brushing your teeth in the morning and evening. Depending on the clinical situation, it is possible to use a double dose of elixir.

A method of preparing a tooth elixir.

Example 1

The number of components is given per 1000 kg of the finished product.

A mixture is prepared of 100 kg of glycerol (polyhydric alcohol) and extracts of sage leaves (40 kg) and eucalyptus leaves (30 kg), stirred at room temperature until completely dissolved.

Then, the extracts of cinnamon rose hips (40 kg), common muzzle (30 kg), creeping thyme grass (40 kg), common viburnum bark (40 kg) are sequentially poured into the reactor, the prepared mixture of glycerin with extracts of medicinal and sage leaves is added and added. eucalyptus. After loading all the components, fragrance (10 kg) and dye (0.1 kg) are added, then Kislovodsk Narzan mineral sparkling water is added until the mixture is completely saturated and stirred for 45 minutes at a temperature of 50 ° C. The resulting liquid was cooled to room temperature and left to stand for 24 hours, then filtered and fed to packaging.

Example 2

Composition, kg:

Polyhydric alcohol 150 Sage leaf extract 80 Eucalyptus Leaf Extract fifty Cinnamon Rose Hip Extract 80 Mordium fruit extract fifty Creeping Thyme Herb Extract 80 Viburnum bark extract 80 Perfume twenty Dye 0.2 Mineral sparkling water Kislovodsk Narzan rest

The method of preparation of the dental elixir of example 2 is similar to example 1.

The organoleptic properties of the obtained elixir are presented in table 1.

Table 1. Appearance Homogeneous clear liquid Example 1 Example 2 Color Straw yellow Tan to brown Smell herbal spicy Taste refreshing, pleasant pH 6.9 7.5-7.9 The content of CO ₂ ,% 6.3 5.5-4.9

The dental elixir according to example 1 can be used in children and adolescents, as in example 2 - in adults.

Good compatibility of these components with known medicinal properties ensures a synergy of their action, leading to the emergence of new properties and a wide range of pharmacological effects.

The proposed dental elixir provides stabilization of saliva buffer tanks, increasing its remineralizing abilities, restores acid-base balance in the oral cavity, has a pronounced anti-inflammatory, keratoplastic and remineralizing effect while maintaining the natural microflora of the oral cavity. The tool helps to reduce and eliminate inflammation in the mucous membrane of the gums and oral cavity in a short period of time and, in addition, does not lead to dysbiosis and the formation of resistant strains of microorganisms.

This complex effect is achieved due to the components introduced into the composition of the elixir.

To determine the effectiveness of these properties of the claimed composition, the Green-Vermilion hygiene index (OHI-S), the PMA index (papillary-marginal alveolar), the Muchlemann index (1958), the gingival index according to Loe, Silness (1967) were determined, and the Schiller-Pisarev test was performed and microbiological examination (contents of the gingival pocket) in comparison with the control group. In addition, we used the Hygiene Efficiency Index (Podshadley and Haley, 1968) and the periodontal PI index (Russel, 1956), which were used to examine all teeth except wisdom teeth. Estimated the condition of the gums around each tooth on a scale of 0 to 8 points. The PI index was determined by dividing the total score by the number of teeth examined. With clinically normal gums, it ranges from 0 to 0.1-0.2, with gingivitis - from 0.1 to 1. Light gingivitis and initial destructive changes correspond to an index of 0.5-1.9, pronounced destructive phenomena - 1 , 5-5, developed and terminal stages - 4-8. To assess the remineralizing properties of the elixir, the TER test was used (V.R.Okushko, L.I. Kosareva, 1983). A drop of 1 N was applied to the vestibular surface of the central upper incisor. hydrochloric acid solution with a diameter of 2 mm. After 5 seconds, the acid was washed off, the enamel was dried and stained with a 1% aqueous solution of methylene blue. The intensity of staining testified to the depth of etching (roughness) of the enamel. This test allows you to evaluate the growth of caries by the degree of acid resistance (functional resistance) of the enamel, in accordance with the level of remineralization and enamel resistance to acid, high tooth resistance to caries was noted as 1-3 points (pale blue), average - 4-6 points ( blue color), low - 7-9 points (blue color), extremely low - 10-12 points (dark blue color).

A total of 196 patients with caries, gingivitis and periodontitis were examined, divided into two groups - the main (developed elixir) and control (prototype). 3 weeks after the start of rinsing with the claimed composition in the main group of patients, indicators of hygiene index and periodontal index (PI) indicated a good condition of the oral cavity and corresponded to the norm for each age group. In 65-70% of patients in the control group, the values of the IG and PI indices after rinsing in the same periods were increased, on average, by 25-40% (Table 2).

Table 2. Evaluation of the effectiveness of the claimed and known composition according to the indices of the IG, PI and TER test The main group of persons examined (the claimed composition) Indicators, points IG PI TER test Before treatment 2.68 ± 0.24 2.78 ± 1.09 7.82 ± 1.04 After rinsing begins, after 2 weeks 1.98 ± 0.11 2.23 ± 0.08 4.94 ± 1.09 After rinsing begins, after 1 month 1.07 ± 0.35 1.09 ± 0.16 4.12 ± 0.22 After rinsing begins, after 2 months 1,03 ± 0,05 0.93 ± 0.06 2.93 ± 0.05 The control group of the examined persons (known composition) Before treatment 2.65 ± 0.35 2.80 ± 1.05 7.86 ± 1.19 After rinsing begins, after 2 weeks 2.34 ± 0.67 2.65 ± 0.90 6.43 ± 1.22 After rinsing begins, after 1 month 1.55 ± 0.61 2.28 ± 0.39 5.21 ± 0.07 After rinsing begins, after 2 months 1.35 ± 0.07 1.97 ± 0.44 4.97 ± 0.35

Assessment of the level of remineralization of tooth enamel according to the TER test showed that regular use of the inventive elixir promotes a more intensive restoration of the mineral composition of tooth enamel, increases its acid resistance by 55.7%, and reduces tooth decay by 34.8% compared with the prototype.

The specified result is presented in specific clinical examples. The studies were conducted on the basis of the Department of Dentistry of the FPO of the Stavropol State Medical Academy and the Stavropol Regional Dental Clinic.

Example 3

Patient A., 34 years old, amb. card number 33012, complained of bleeding and pain in the gums when brushing your teeth and eating, bad breath. Objectively, the bite is orthognathic, the mucous membrane of the oral cavity is red-pink in color, moderately moistened, in the area of the chewing teeth of the lower jaw - hyperemic, edematous. The surface of the gums is smooth, glossy, with slight bleeding when touched. The Schiller-Pisarev test is strongly positive. IG (OHI-S) was 2.5 points, PI index - 4.3 points (poor oral hygiene, dental deposits, gingivitis), TER-test - 7.8 points.

Treatment: etiotropic (removal of dental plaque with an ultrasonic scaler, replacing low-quality fillings), pathogenetic (electrosleep, HBO therapy, immunomodulators), symptomatic - rinsing with a developed dental elixir. After 2 weeks of rinsing, the patient complains of pain and bleeding gums, the Schiller-Pisarev test is weakly positive, the IG index is 1.75 points, and the PI index is 2.9 points. After 1 month, the Schiller-Pisarev test is negative, the TER test is 3.32 points, the IG index is 1.04 points (good hygiene), the PI index is 1.35 points, which indicates the complete elimination of the inflammatory process in the mucous membrane of the cavity mouth and a sharp decrease in the intensity of plaque formation. At the control examination after 3 months there were no complaints, TER test - 2.8 points (high structural and functional enamel resistance, high resistance to caries, good level of tooth enamel remineralization). The patient is recommended to repeat the rinse 3-4 times a year for 10 days.

Example 4

Patient S., 49 years old, amb. card No. 12093, complained of bleeding gums when brushing your teeth and eating, an aesthetic disadvantage was increased gums and bad breath. Previously, such phenomena were not noted, an allergic history is not burdened. Objectively, in the oral cavity the mucous membrane of the gums in the region of 14, 17, 23, 24, 26, 34, 35, 36 is hyperemic, edematous, the gingival papillae are increased in size by 1/3, partially ulcerated, rounded, bluish in color, bleed from touch . The PMA index revealed an average degree of gingivitis, an edematous form, IG (OHI-S) - 2.9 points, PI - 4.7 points (poor oral hygiene, dental deposits, hypertrophic and ulcerative gingivitis). TER test - 8.93 points (reduced structural and functional resistance of tooth enamel, high risk of caries).

Treatment. Etiotropic (removal of dental plaque by an ultrasonic scaler, replacement of poor-quality fillings, surgical treatment of caries, replacement of a bridge in the area of 14-17 teeth), pathogenetic (immunomodulators, electrophoresis with vitamin C), symptomatic - rinsing with a developed dental elixir 5-7 times a day.

After 2 weeks of treatment, the patient complains of pain and bleeding of the gums, the Schiller-Pisarev test is weakly positive, the IG index is 1.88 points, and the PI index is 3.09 points. After 1 month, the Schiller-Pisarev test is negative, the IG index is 0.93 points (good hygiene), the PI index is 1.07 points, which indicates the relief of the inflammatory process in the oral mucosa, periodontal disease and a decrease in the amount of plaque. TER test - 4.03 points. At the follow-up examination after 3 months TER-test - 3.25 points (average resistance to pain), after 6 months TER-test - 2.09 points (high resistance to caries, high level of enamel remineralization), complaints of pain and bleeding gums There is no hyperesthesia of enamel. A microbiological study showed that the composition of the natural microflora of the oral cavity after rinsing has not changed, the use of the inventive composition of the elixir promotes the growth of lactobacilli, i.e. allows you to restore acid-base balance in the oral cavity (pH 7.2-7.4) and maintain microbiocenosis. The patient is recommended to repeat rinsing 3-4 times a year for 10 days per course.

Thus, the claimed tool has a pronounced anti-inflammatory, keratoplastic (wound healing) and remineralizing effect, which allows it to be used successfully for the prevention and treatment of diseases of the oral mucosa, inflammatory diseases of periodontal tissues, as a remineralizing therapy with an effect that exceeds that of known means used for similar purposes.

Information sources

1. N.V. Kuryakina, N.A. Saveliev. Dentistry is prophylactic. - Minsk, Publishing House NGMA, 2005, p.210-214.

2. N.V. Kuryakina et al. Medicinal plants and beekeeping products used in dentistry. - M., Medical Book, N. Novgorod, Publishing House NGMA, 2000, p. 22-180.

3. Yakovleva V.I., Trofimova E.K., Davidovich T.P., Prosviryak G.P. Diagnosis, treatment and prevention of dental diseases. Minsk, Higher School, 1994, p. 471.

4. Muravyova D.A. Pharmacognosy: A Textbook. - M .: Medicine, 1991, p.175, p.144.

Claims (1)

Treatment-and-prophylactic tooth elixir containing polyhydric alcohol-glycerin, extracts of medicinal plants, characterized in that it contains extracts of medicinal sage leaves, eucalyptus, cinnamon rose hips, common muzzle, thyme creeping grass, common viburnum bark, as well as fragrance, dye and mineral water carbonated "Kislovodsk Narzan" in the following ratio of components, wt.%:
glycerol 10-15 sage leaf extract 4-8 eucalyptus leaf extract 3-5 cinnamon rose hips extract 4-8 common muzzle fruit extract 3-5 creeping thyme herb extract 4-8 Viburnum bark extract 4-8 perfume 0.1-0.2 dye 0.001-0.002 sparkling mineral water Kislovodsk Narzan rest