RU2376008C1 - Base for toothpaste - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention is related to stomatology, in particular to toothpaste base. Toothpaste base, which contains ground shells of cedar nuts as abrasive material and glycerin as moisture-holding substance, cedar oil and cedar gum as biologically active additive, essence of cedar cones or needle as preservative or perfume, and also sodium carboxymethylcellulose, demineralised water, with a certain ratio of components.

EFFECT: described base for toothpaste provides for good anti-inflammatory healing antiseptic deodorising and cleaning effect, stimulates processes of microcirculation and remineralisation of teeth enamel, improves trophism of periodontium tissues, increases their non-specific resistance, eliminates hypoxia.

2 tbl, 4 ex

Description

The invention relates to medicine, namely to dentistry, and relates to therapeutic and prophylactic agents used for the care of teeth and oral cavity.

The main task in creating the foundations for new toothpastes is a rational combination of biologically active components with carioprophylactic and anti-inflammatory activity, taking into account adequate consumer properties - cleansing, bleaching and deodorizing effects (1, 2). The carioprophylactic effect depends on the presence of fluorine-containing compounds in the composition of pastes - pyrophosphates, sodium fluoride, sodium monofluorophosphate and others (3, 4).

Extracts of various plants are usually used as anti-inflammatory components that reduce inflammation of the mucosa during periodontal disease (5, 6).

Known, for example, toothpaste containing chalk, glycerin, sodium carboxymethyl cellulose, Tween-80, pine coniferous foot extract, sodium monofluorophosphate, xylitol, preservative, perfume oil, perfume and water (7). Known paste has a good carioprophylactic effect, a good cleansing and refreshing effect, however, it has a weak anti-inflammatory, anti-periodontal and whitening effect.

The closest to the claimed basis for toothpaste - the prototype is the basis for toothpaste containing pine nut shell powder, silicon dioxide, sorbitol, sodium carboxymethyl cellulose, sodium monofluorophosphate, sodium fluoride, titanium dioxide, methyl paraben sodium salt (8).

The disadvantages of the known basis for toothpaste are:

- Pine nut shell powder is used only as a biologically active component, and silicon dioxide is used as an abrasive component;

- low anti-inflammatory properties of the base, since other biologically active products of cedar processing have not been used.

An object of the invention is to create a basis for toothpaste containing cedar processing products, which, when used, can provide the effect of removing dental plaque, as well as treating and preventing periodontal diseases.

The technical task is achieved by the proposed basis for a toothpaste containing the following components, wt.%:

Ground pine nutshell 9.0-11.0 Cedar resin 4,5-5,5 Cedar Oil 4,5-5,5 Essential oil of cones or cedar needles 2.5-3.0 Carboxymethyl cellulose (from cedar) 1.0-1.2 Glycerol 50.0-55.0 Demineralized water up to 100%

The basis for toothpaste is made as follows.

Pre-prepared aqueous-glycerin solution of sodium-CMC. To do this, in a container equipped with an anchor mixer, half (from the required by the recipe) amount of water, glycerin, sodium-CMC is loaded and mixed until a mass containing no large lumps of sodium-CMC is formed. Then add the remaining water and mix until a homogeneous mass. Then, the basis for the toothpaste is prepared, for which, successively ground pine nutshell shells, pine pine gum, pine nut oil and essential oil from pine cones or pine needles are added to the container with the prepared solution with stirring. The whole process of obtaining pastes is carried out without heating at a temperature of 18-25 ° C.

The proposed basis is a finely divided homogeneous elastic mass of dark brown color, with a pleasant smell of cedar needles and a bitter, tart taste.

The essential features of the invention should be considered the qualitative and quantitative composition of the base, as well as the introduction of the base as an abrasive component, a thickener and a biologically active component - ground pine nutshell. Currently, silicon compounds are widely used as fillers for toothpastes, including silicon dioxide in the form of a powder.

As a biologically active component in the composition of the base for the production of toothpaste, pine nutshell, gum cedar and cedar oil are introduced, which allows to increase the anti-inflammatory, healing, antiseptic, deodorizing and cleaning effects of the base.

A brief description of the components that make up the basis for toothpaste.

Pine nutshell is an abrasive material, at the same time fulfilling the role of filler and structure-forming agent, creating a homogeneous, thixotropic paste mass. Pine nut shells are used in the form of a powder with a particle size of 30-60 microns. Pine nut shell consists mainly of cellulose (69%) and hemicellulose (23%), in addition, it contains lignin, a small amount of tannins, fat and protein, and has excellent taste and aromatic properties. Due to the lipids, flavonoids, tannides, proteins, polysaccharides, potassium, phosphorus, magnesium, iron, calcium, zinc and copper contained in it, the pine nut shell provides a wound healing, strengthening, fortifying, tonic effect on periodontal tissues and oral mucous membranes.

Cedar oil has great biological value due to its content of vitamins A, B, D, E, amino acids, micro and macro elements, liquid and solid fatty acids, lecithin, phytosterol, is well absorbed by the body. Cedar oil is a concentrate of vitamin F - it is an essential fatty acid: palmitic, stearic (saturated) and extremely unsaturated. c: oleic (up to 35.8%), gadoleic (up to 1.04%), linoleic (up to 71.1%) and linolenic (up to 27.75%).

Essential oil from pine needles or cones of cedar, which has a pleasant coniferous aroma, is used as a fragrance, as well as an antiseptic. The essential oil contains terpene hydrocarbons, zedrol, sequilerpenes, it has a high bactericidal activity. Cedar essential oil is obtained from pine needles or cones by water-steam distillation.

Cedar resin is obtained by cutting ripe stands, it contains the natural amount of bioflavonoids that have antioxidant, capillary-protective, anti-inflammatory, anti-allergic and decongestant properties. This complex of biologically active substances has an anti-inflammatory, hemostatic, antiseptic effect, affects the microcirculation processes, enhancing the trophism of periodontal tissues, increasing their resistance, strengthens capillaries, dissolves soft dental deposits.

Glycerin gives the paste plasticity and frost resistance, retains moisture and forms a texture.

Sodium carboxymethyl cellulose (sodium CMC) is a gelling component.

Other biologically active components and sweetening components may be added to the proposed base.

The invention is illustrated by examples of formulations of the claimed basis for toothpastes.

Example 1

The basis for toothpaste contains the following components, wt.%:

Ground pine nutshell 10.0 Cedar resin 5,0 Cedar Oil 5,0 Cedar needles essential oil 3.0 Sodium carboxymethyl cellulose 1,0 Glycerol 52.0 Demineralized water rest

Example 2

The proposed basis for toothpaste contains the following components, wt.% :,

Ground pine nutshell 9.0 Cedar resin 4,5 Cedar Oil 4,5 Cedar needles essential oil 2.5 Sodium carboxymethyl cellulose 1,0 Glycerol 50,0 Demineralized water rest

Example 3

The proposed basis for toothpaste contains the following components, wt.%:

Ground pine nutshell 11.0 Cedar resin 5.5 Cedar Oil 5.5 Cedar needles essential oil 3.0 Sodium carboxymethyl cellulose 1,2 Glycerol 55.0 Demineralized water rest

To obtain a new toothpaste, a biologically active component from natural raw materials (propolis) and a sweetener (xylitol) are added to the proposed base.

Example 4. Toothpaste contains the following components, wt.%:

Ground pine nutshell 10.0 Cedar resin 5,0 Cedar Oil 5,0 Cedar Cones Essential Oil 3.0 Sodium carboxymethyl cellulose 1,0 Glycerol 55.0 Water-alcohol infusion of propolis 1.9 Xylitol 0.1 Water rest

The proposed basis for toothpastes provides a good anti-inflammatory, healing, antiseptic, deodorizing and cleansing effect, stimulates the processes of microcirculation and remineralization of tooth enamel, improves trophism of periodontal tissues, increases their non-specific resistance, eliminates hypoxia, does not irritate the mucous membrane and is harmless with prolonged use, does not cause erasing tooth enamel.

The proposed toothpaste base has been tested in vitro and clinically by volunteers. Tests of the basis for toothpaste were carried out in accordance with the requirements of the "Methodological guidelines of the Ministry of Health of the USSR for experimental (pharmacological) and clinical testing of preventive and therapeutic toothpastes", 1983

1. Assessment of organoleptic properties.

When studying the organoleptic properties of the paste, the evaluation of the appearance, color, taste and smell by the probants was taken into account.

The tested paste, according to the testants, has a pleasant tart taste, aroma, good distribution in the mouth.

2. Evaluation of the cleansing action.

A generally accepted criterion for evaluating the cleaning properties of toothpastes is the presence of soft plaque after brushing. To quantify it, use plaque indices, the so-called hygiene indices, which are determined before and after using toothpaste.

Clinical trials were conducted on a group of patients (28 people) with gingivitis and periodontitis using the basis for the paste from example 1. Toothpaste was applied twice a day (morning and evening) after meals. The course of use was 30 days. As a reference standard used therapeutic and prophylactic toothpaste "Forest". The observation results confirmed the good therapeutic and prophylactic effect of the proposed basis for toothpaste in comparison with hygienic and other therapeutic and preventive toothpastes (Tables 1, 2). All subjects immediately after brushing noted an improvement in the condition of their teeth and oral cavity. After applying the paste, the RMS index averaged 13.3 ± 2.1, the hygiene index 1.5 ± 0.3 points, and the resistance of the gingival capillaries 37.0 ± 1.0 seconds.

Toxicological tests showed the absence of acute toxicity when administered orally, the absence of irritating effects on the oral mucosa.

Example 5

Patient A., 64 years old, turned to a dental clinic with complaints of bleeding gums, periodontal disease, and inflammatory phenomena. Examination results: dentin hyperosthesia, RMS index - 30.4%, hygiene index - 2.3 points, resistance of gingival capillaries - 24 sec. After 30 days of using the proposed base for toothpaste, the gum condition improved significantly: no complaints, bleeding and signs of inflammation disappeared. After applying the paste, the RMS index was 11.2, the hygiene index was 1.8 points, and the resistance of the gum capillaries was 36 seconds.

Example 6

Patient S., 54 years old, turned to a dental clinic with complaints of bleeding gums, inflammation, and yellow teeth. Examination results: dentin hyperosthesia, RMS index - 26%, hygiene index - 2.9 points, resistance of gingival capillaries - 26 sec. After 30 days of using the proposed toothpaste, the gum condition improved significantly: there were no complaints, bleeding and signs of inflammation disappeared, dental deposits disappeared. The RMS index is 15.4%, the hygiene index is 1.2 points, the resistance of the capillaries of the gums is 38 seconds.

Thus, the use of the proposed basis for toothpaste will allow, in comparison with the prototype, to improve trophism and condition of periodontal tissues, remove dental deposits, relieve bleeding gums and provide prevention of tooth decay and periodontal disease. The developed basis for the production of toothpaste provides a good cleaning and therapeutic effect on tooth and periodontal tissues by enhancing the processes of remineralization of tooth tissues, improving metabolic processes in periodontal tissues, as well as increasing enamel resistance, which is ensured by the formation of a microfilm on the tooth surface after brushing .

Information sources

1. Omelchenko N.V. Antimicrobial properties of therapeutic toothpastes. - In the book: Comprehensive treatment and prevention of dental diseases. - Kiev, 1989, p. 75-85.

2. Fedorova L.V. Development of therapeutic and prophylactic toothpastes with biologically active components. Diss. Cand. honey. sciences. - L., 1987.

3. Copyright certificate of the USSR No. 1500308, cl. A61K 7/16, 1989.

4. Copyright certificate of the USSR No. 1657188, cl. A61K 7/16, 1991.

5. RF patent No. 2012329, cl. A61K 7/16, 1991.

6. RF patent No. 2112501, cl. A61K 7/16, 1998.

7. Copyright certificate of the USSR No. 942756, cl. A61K 7/16, 1982.

8. RF patent No. 2236154, cl. A61K 7/00, 2004.

Table 1 Toothpastes Number of patients Hygiene Index, score RMS index,% The resistance of the capillaries of the gums, sec before treatment after treatment before treatment after treatment before treatment after treatment The inventive paste 28 2.6 ± 0.3 1.5 ± 0.3 28.2 ± 2.2 13.3 ± 2.1 25.0 ± 1.0 37.0 ± 1.0 Pasta "Forest" 28 2.7 ± 0.2 1.9 ± 0.2 26.2 ± 3.1 20.9 ± 2.8 25.1 ± 0.3 29.2 ± 0.2

Claims (1)

The basis for toothpaste, characterized in that it contains ground pine nutshell shells as abrasive material, glycerin as a water-retaining substance, cedar oil and cedar gum as a biologically active additive, essential oil of cones or cedar needles as a preservative and perfume as well as sodium carboxymethyl cellulose, demineralized water in the following ratio of components, wt.%:
Ground pine nutshell 9.0-11.0 Cedar resin 4,5-5,5 Cedar Oil 4,5-5,5 Essential oil of cones or cedar needles 2.5-3.0 Sodium carboxymethyl cellulose 1.0-1.2 Glycerol 50.0-55.0 Demineralized water Up to 100%