SU1132945A1 - Tooth paste - Google Patents

Abstract

DENTAL PASTE containing chalk, sodium carboxymethyl cellulose, paraoxybenzoic acid propyl ester. xylitane, glycerin, perfume oil, otduschku and water. In order to increase its anti-inflammatory effect and treatment of inflammatory diseases of the oral mucosa and paradontoza, it additionally contains extracts of turmeric or ginger, with the following ratio of components, May %: A piece of chalk. 39-42 Glycerin 10-14 Xylitane8-12 Sodium carboxymethylcellulose I -1,5 Propyl para-benzoate benzoate 0.3-0.7 Perfume oil1.0-1.2 i Turmeric extract or ginger 0.05-1.0 SL C Fragrance 0.5 -1.0 Water Else

Description

 to with 4; The invention relates to the manufacture of therapeutic and prophylactic agents for the oral cavity. Known toothpastes containing chalk, glycerin, Na-CMC, sodium lauryl sulfate, antiseptic, perfume oil, perfume and water, extracts of medicinal plants. Recipe produced at present, its pasta time, wt.%: 38-40 Xylitane Na-CMC Distilled glycerin 10-12 0.2-0.3 Sodium lauryl sulphate Carbon dioxide extract 0.3-0.5 m ty You Perfume oil Antiseptic 0.3-0.5 Perfume 0.6-1 Else Paste is designed for. improvement of metabolic processes in hard tissues of teeth and has an anti-caries effect 1. However, the paste is known to have a bactericidal and anti-inflammatory effect. The purpose of the invention is to increase the anti-inflammatory effect of the paste on the tissues of the oral cavity and the treatment of certain diseases of the oral mucosa and marginal paradontosis. The goal is achieved by the fact that in a paste containing chalk, xylitane, sodium carboxymethyl cellulose, perfume oil, antiseptic, fragrance and water, turmeric extracts or ginger are added in the following ratio, wt.%: Components. (Ji ... ., Free organic acids. Fatty acids of triglycerols. Unwashed substances, hydrocarbons, alcohols, carbonyl compounds. Exemplary substances. Phenols, acids. Water-soluble and other substances. Mel39-42 Glycerin 10-14 Xylitane 8-12. Sodium carboxymethylcellulose 1, 0-1.5. para-oxybenzoic acid 0.3-0.7 Perfume oil1.0-1.2 Turmeric extract or ginger 0.05-1.0 Odorant 0.5-1.0 WaterOtherly The introduction of turmeric extract or ginger into the paste helps to improve the metabolic processes in the mucous membrane of the oral cavity has a more active influence on the vascular system of the paradont and, therefore, has 4 anti-inflammatory effects, such as turmeric or ginger, which are contained in it, which belong to groups of complex organic compounds in both free and related form (alkaloids, terpene fraction, fatty acid complex of group F, camphor, phenolic compounds, etc.). According to chemical studies of the essential oil of turmeric or ginger, it is known that the substances contained in them cause a refreshing and cooling effect, which made it possible to work out the optimal dosages when injected into a paste. The main components of the turmeric essential oil are the following components: pinene 2,3, ° C and / J- turmeric 54, turmerone 8.0, camphor 7.9, alcohols (including cumene, ketospirits) 17 and other substances. Characterization of the composition of the COA-extract of turmeric is shown in Table. 1. Table 1 COj, - extract,%

Thus, it can be seen from this that the CO2 extract of turmeric contains, in addition to the essential oil, fat-soluble biologically active substances. The lipid fraction of the extract is represented by directly free and bound fatty acids, etc.

The fatty acid composition of the lipid fraction of the CO2 extract in the composition of free acids is mainly represented by unsaturated fatty acids — oleic, linoleic, and liolenic — and the bound acids contain these large quantities in much larger quantities.

Unsaturated acids that have several double bonds (linolene, linolenova, etc.) are biologically active, they are called vitamins F. In addition to a number of positive properties due to which vitamin F is introduced into cosmetic products, it also has the ability to activate the effects of other vitamins (Ai, DZ, EI carotene) contained in vegetable oils.

Physico-chemical properties of extracts - turmeric: the appearance of the oil is yellow to brown liquid, the taste is spicy and bitter, the smell is characteristic camphor and ginger, the mass fraction of water is not more than 5.0%, the density at 20 ° С is 0.9178- 0.9724 g / cm, refractive index at 20 ° С 1.4930-1.5271, acid number not more than 20.0 mg KOH, solubility in EB / o-alcohol when heated at 1: 5;

ginger: the appearance of oily oil is light brown to dark brown, the taste is spicy, ozgozhguschy, the smell is very pronounced, characteristic ginger, the moisture content is not more than 1.0%, the density at 20 ° С is 0.9000-0, 97000, ki “lot number not more than 18.0 mg KOH.

Make pasta as follows.

Glycerin and xylitan are loaded into the boiler equipped with a root stirrer. Include

Example 1. The pasta recipe is as follows:

a piece of chalk

Glycerol

Xylitan

Sodium carboxymethylcellulose

Para-benzoic acid propyl ester

Perfume oil

the mixer and the contents of the boiler are mixed for 5 minutes. Then, while operating the mixer, manually add sodium KMTS gradually. Stirring is continued for 40 minutes until a mass that does not contain large lumps of sodium-CMC is formed. Thereafter, water is supplied to the boiler and stirring is continued for 3 hours until a homogeneous mass is obtained. At the same time, sodium lauryl sulfate is poured into an enamelled tank by preparing sodium-CMC solution and water with a temperature of 40-50 ° C is added. For 1 hour, the contents of the tank are stirred 2-3 times with a paddle until the sodium lauryl sulfate is completely dissolved. The sodium-CMC solution is pumped to the kneader and, while the agitator is in operation, turmeric extract or ginger is added, mixed, and gradually, chalked for 1 hour. At the same time, perfume oil is added manually. With the last piece of chalk, manually give a flavoring agent with paraoxybenzoic acid propyl ether previously dissolved in it. Stirring is continued for another 30 minutes after the end of the flow of chalk. Aqueous solution of sodium lauryl sulfate is added and mixed for another 10 minutes.

To make the paste homogeneous, it is passed through a colloid mill. After that, the toothpaste is packaged.

To improve the palatability of the paste, it is necessary to use a perfume of the following composition: amylacetate, vanillin 1% alcohol solution, sweet orange oil, anise oil, lemon oil, mint oil, menthol.

The use of the proposed recipe for flavoring is due to the spicy bitter taste of turmeric extract or ginger, which requires the introduction of substances with a sweet taste (orange, aniseed oil and DR-) kg

39.0 14.0 10.0

1.0

0.3 1.0

Turmeric carbon dioxide extract or ginger

Odorant

Water

Example 2. Recipe pasta

wt.%

kg

a piece of chalk

Glycerol

Xylitan

Sodium carboxymethylcellulose

Paraxybenzyl propyl ester

Perfume oil

Turmeric extract or ginger

Odorant

Water

Example 3. Recipe na

a piece of chalk

Glycerol

Xylitan

Sodium carboxymethylcellulose

Paraxybenzyl propyl ester

Perfume oil

Turmeric extract or ginger

Odorant

Water

Turmeric extract tested in patients with hermetic closure. The extract of curc various forms of periodontitis, teeth fct-55 we or ginger is active in the treatment of chronitoric did not withstand hermetism. Already posterior apical periodontitis and pulley of odiokratny introduction of an extract of the cock-pit. Comparative assessment of it with other

, we on the turunda teeth began to withstand essential oils (clove, cinnamon.

nutmeg sage, peppermint oil showed that turmeric oil and ginger has a pronounced anti-inflammatory effect, does not irritate periodontal tissue, and has a detrimental effect on the root canal microflora.

The use of the proposed paste makes it possible to improve the treatment-and-prophylactic treatment of the oral cavity and has a certain therapeutic effect in relation to one hundred tons (control) Aira (known)

Offered As a result of additional studies, it has been established that the proposed toothpaste has a capillary strengthening effect and helps to reduce bleeding of the gums, reduces inflammation. Studies were also conducted in comparison with the effects of other pastes, namely, Lesna and Aira (known) toothpaste. In clinical trials, people who suffer from paradontosis with the severity of inflammation and bleeding of the gums took part. The subjects during the month during the intercourse period of treatment of paradontosis were dried twice a day by brushing the teeth with these pastes. As an objective test, Schiller-Pisarev's inflammatory test and bleeding tests were used: persistence of capilmatological diseases, such as inflammatory diseases of the oral mucosa and paradontosis.

The paste has a pleasant taste, is fragrant, and also has an ochish, ayush, and their properties.

The effect of the proposed toothpaste and the degree of atrophy of the alveolar process of the jaws of rats known is presented in Table. 2

table 2

36.7 ± 1.03 32.13 ± 1.01 P 0.05 31.56 ± 0.934 P 0.01 l ditch according to V. I. Kulazhenko and the hemoglobin content in saliva. Objective tests were evaluated before applying toothpastes and one month after the beginning of brushing with the tested pastes. Research results have shown that the proposed toothpaste has the most pronounced anti-inflammatory and capillary strengthening effect, and the amount of hemoglobin in the saliva after applying the proposed toothpaste is reduced more than 2.5 times. After using toothpaste "Lesna and" Aira, this effect is negligible. The effect of the proposed toothpaste on inflammation and bleeding of the gums in patients with paradontosis is presented in Table. 3

go

vO

sa c h y h) n

CM

cm

cm

4-1

4-ti

+1 w

see o cho o o o

h

h LO

sh

"H" h

oh oh

-sG

with

+1

SP

to

G cho

+ (

with VO

fe

 Ltd

h

1L

g m

 "H

oh oh

cm

four(

Claims (1)

DENTAL PASTE containing chalk, sodium carboxymethyl cellulose, paraoxybenzoic acid propyl ester, xylitane, glycerin, perfume oil, perfume and water, characterized in that in order to increase its anti-inflammatory effect and treat inflammatory diseases of the oral mucosa and periodontosis, it is additionally introduced extracts of turmeric or ginger, in the following ratio, May. ° / ₀ : a piece of chalk . 39–42 Glycerol 10-14 Xylitan 8-12 Sodium carboxymethyl cellulose 1-1.5 Paraoxybenzoic acid propyl ester 0.3-0.7 Perfume oil 1.0-1.2 q Turmeric Extract or ~ ginger 0.05-1.0 Perfume 0.5-1.0 Water Rest SU „„ 1132945