RU2228167C1 - Tooth paste - Google Patents

Abstract

FIELD: medicine, stomatology. SUBSTANCE: the present innovation deals with curative- prophylactic tooth pastes. The suggested tooth paste contains silicon dioxide, glycerol or sorbitol, Na- carboxymethylcellulose, sodium laurylsulfate, sodium fluoride or monofluorophosphate, calcium carbonate or glycerophosphate, extract obtained out of Siberian larch resin, conservant, saccharin or xylite, fragrance, food dyeing substance, water. All the components are taken in certain quantitative content. The suggested paste is of caries-prophylactic, antiphlogistic, antiparodontium, hemostatic and antiseptic action, affects microcirculation processes by enhancing the trophics of parodontium tissues. EFFECT: higher whitening action. 1 cl, 5 ex, 2 tbl

Description

The invention relates to medicine, namely to dentistry and relates to therapeutic and prophylactic preparations used for the care of teeth and oral cavity.

The main task when creating new toothpastes is a rational combination of biologically active components with carioprophylactic and anti-inflammatory activity, taking into account adequate consumer properties - cleansing, bleaching and deodorizing effects [1, 2].

The carioprophylactic effect depends on the presence of fluorine-containing compounds in the composition of pastes - pyrophosphates, sodium fluoride, sodium monofluorophosphate and others [3, 4].

Extracts of various plants are used, as a rule, as anti-inflammatory components that reduce inflammation of the mucosa during periodontal disease [5, 6].

Known, for example, toothpaste containing chalk, glycerin, sodium carboxymethyl cellulose (sodium CMC), Laminaria concentrate, polyvinylpyrrolidone, thymol, paraoxybenzoic acid propyl ester, sodium lauryl sulfate, perfume oil, perfume, 7 saccharin and water. Known paste contributes to the treatment and prevention of periodontal disease and dental caries, but does not provide removal of dental plaque, stop bleeding gums and whitening tooth enamel.

Known toothpaste containing chalk, sodium-CMC, glycerin or sorbitol, sodium lauryl sulfate, preservative, vitamin E, dicalcium phosphate, perfume, perfume oil, sodium sugar and water [8]. Known paste has anti-inflammatory properties and increases the amount of saliva, however, it has a low carioprophylactic, anti-periodontal and whitening effect.

Closest to the claimed toothpaste - the prototype is a toothpaste containing chalk, glycerin, sodium carboxymethyl cellulose, Tween-80, fir coniferous foot extract, sodium monofluorophosphate, xylitol, preservative, perfume oil, perfume and water [9]. Known paste has a good carioprophylactic effect, a good cleansing and refreshing effect, however, it has a weak anti-inflammatory, anti-periodontal and whitening effect.

An object of the invention is the creation of a new toothpaste, which allows using it to provide the effect of teeth whitening, removing dental plaque, as well as the treatment and prevention of periodontal diseases.

The technical task is achieved by the proposed toothpaste containing the following components, wt.%:

Silica 17.0-25.0

Glycerin or sorbitol 24.0-32.5

Sodium carboxymethyl cellulose 0.6-2.0

Sodium Lauryl Sulfate 0.5-2.0

Sodium fluoride or sodium monofluorophosphate 0.2-0.8

Calcium carbonate or calcium glycerophosphate 0.8-1.2

Siberian Larch Resin Extract 5.0-7.0

Preservative (propyl or methyl esters

paraoxybenzoic acid or sodium benzoate) 0.3-0.5

Saccharin or Xylitol 0.05-0.2

Fragrance 0.6-1.5

Food color 0.002-0.01

Water Else

Toothpaste is made as follows.

Pre-prepared aqueous-glycerin (sorbitol) solution of sodium-CMC. To do this, in a container equipped with an anchor mixer, load half (of the required by the recipe) amount of water, glycerin (sorbitol), sodium-CMC and mix until a mass containing no large lumps of sodium-CMC is formed. Then add the remaining water and mix until a homogeneous mass. Then toothpaste is prepared, for which purpose silicon dioxide, sodium lauryl sulfate, sodium fluoride (or sodium monofluorophosphate), calcium carbonate (or glycerophosphate) calcium, an aqueous extract from Siberian larch resin, a preservative, saccharin (xylitol) are added to the container with the prepared solution with stirring. , fragrance and dye. The whole process of obtaining pastes is carried out without heating at a temperature of 18-25 ° C.

Fragrance for the proposed toothpaste has a pleasant fruity mint smell.

Examples of formulations of the proposed toothpaste.

Example 1

Toothpaste contains the following components, wt.%:

Silica 17.0

Glycerin 32.5

Sodium Carboxymethyl Cellulose 2.0

Sodium Lauryl Sulfate 0.5

Sodium fluoride 0.2

Calcium Carbonate 0.8

Siberian Larch Resin Extract 5.0

Paraoxybenzoic acid propyl ester 0.3

Saccharin 0.05

Fragrance 0.6

Food color 0.002

Water Else

Example 2

Toothpaste contains the following components, wt.%:

Silica 25.0

Glycerin 24.0

Sodium carboxymethyl cellulose 0.6

Sodium Lauryl Sulfate 2.0

Sodium fluoride 0.3

Calcium Carbonate 1.2

Siberian Larch Resin Extract 7.0

Paraoxybenzoic acid methyl ester 0.5

Saccharin 0.2

Fragrance 1.5

Food color 0,01

Water Else

Example 3

The proposed toothpaste contains the following components, wt.%:

Silica 23.0

Sorbitol 27.0

Sodium carboxymethyl cellulose 1.2

Sodium Lauryl Sulfate 1.5

Sodium Monofluorophosphate 0.8

Calcium Glycerophosphate 1.0

Siberian Larch Resin Extract 6.0

Sodium Benzoate 0.4

Xylitol 0.1

Fragrance 1.0

Food color 0.007

Water Else

The proposed toothpaste provides a good anti-inflammatory, healing, antiseptic, deodorizing and cleansing effect, stimulates the processes of microcirculation and remineralization of tooth enamel, improves trophism of periodontal tissues, increases their non-specific resistance, eliminates hypoxia, and also whitens tooth enamel well.

The essential features of the invention should be considered the qualitative and quantitative composition of the paste, as well as the introduction of a paste of the aqueous extract from the resin of Siberian larch.

A brief description of the components that make up the paste.

Silicon dioxide is an abrasive material, at the same time fulfilling the role of filler and structure-forming agent, creating a homogeneous, thixotropic paste mass. Glycerin (or sorbitol) gives the paste plasticity and frost resistance, retains moisture and forms a texture; sodium carboxymethyl cellulose (sodium CMC) is a gelling component; sodium fluoride (or sodium monofluorophosphate) is an anticaries agent added to the formulation to stimulate the mineralization of tooth tissues; calcium carbonate (or glycerophosphate) - a source of active calcium to improve the mineralization of the teeth and bones of the alveolar process; sodium lauryl sulfate - a surfactant that is a foaming component; saccharin (or xylitol) - a sweetening component that improves the taste of the paste; a preservative is added to preserve, increase shelf life and prevent microbial infection; fragrance is added to give the paste a pleasant smell, and dye is used to provide the desired color.

As a biologically active component, an aqueous extract of Siberian larch resin is introduced into the paste, containing the natural amount of bioflavonoids with antioxidant, capillary-protective, anti-inflammatory, anti-allergic and anti-edematous properties. This complex of biologically active substances has an anti-inflammatory, hemostatic, antiseptic effect, affects microcirculation processes, enhancing trophism of periodontal tissues, increasing their resistance, strengthens capillaries, dissolves soft dental deposits, and has a whitening effect.

The aqueous extract is obtained by extraction of resin (gum) of larch Siberian hot (90-98 ° C) water in the ratio of raw material - extractant 1: 10-20, followed by concentrated extract obtained.

Toxicological tests showed the absence of acute toxicity when administered orally, the absence of irritating effects on the oral mucosa.

Clinical trials were conducted on a group of probans aged 20-35 years (32 people) with periodontal diseases, as well as on a group of male smokers (12 people) with dental plaque and brown plaque on tooth enamel. The observation results confirmed the good therapeutic and prophylactic effect of the proposed toothpaste in comparison with hygienic and other therapeutic and prophylactic toothpastes (Tables 1, 2). Toothpaste was applied twice a day (morning and evening) after meals. The course of use was 30 days.

Example 4

Patient B., 54 years old, turned to a dental clinic with complaints of bleeding gums, periodontal disease, inflammation, and yellowness of teeth. Examination results: dentin hyperosthesia, RMS index - 48%, hygiene index - 2.7 points, durability of gingival capillaries - 22 seconds. After 30 days of using the proposed toothpaste, the gum condition improved significantly: there were no complaints, bleeding and signs of inflammation disappeared, and a noticeable whitening effect was observed. The RMS index is 26.7%, the hygiene index is 1.3 points, the resistance of the capillaries of the gums is 38 seconds.

Example 5

Patient K., 34 years old, turned to a dental clinic with complaints of bleeding gums, inflammation, and yellowness of teeth. Survey results: dentin hyperosthesia, RMS index - 28%, hygiene index - 2.5 points, the resistance of gingival capillaries - 27 seconds. After 30 days of using the proposed toothpaste, the gum condition improved significantly: there were no complaints, bleeding and signs of inflammation disappeared, a noticeable whitening effect was observed, and dental deposits disappeared. The RMS index is 14.4%, the hygiene index is 1.2 points, the resistance of the gum capillaries is 36 seconds.

Thus, the use of the proposed toothpaste will allow, in comparison with the prototype, to improve the trophism and condition of periodontal tissues, to achieve the effect of whitening and removal of dental plaque, to relieve bleeding gums and to prevent caries and periodontal disease. The developed toothpaste provides a good cleansing and therapeutic effect on tooth and periodontal tissues by enhancing the processes of remineralization of tooth tissues, improving metabolic processes in periodontal tissues, as well as increasing enamel resistance, which is ensured by the formation of a microfilm on the surface of the teeth after brushing.

The proposed toothpaste has good taste, refreshing and whitening properties. Its systematic use reduces the incidence of teeth and periodontal disease, and also improves the color of tooth enamel.

Sources of information

1. Omelchenko N.V. Antimicrobial properties of therapeutic toothpastes. - In the book: Comprehensive treatment and prevention of dental diseases. - Kiev, 1989, p. 75-85.

2. Fedorova L.V. Development of therapeutic and prophylactic toothpastes with biologically active components. Diss. Cand. honey. sciences. - L., 1987.

3. Copyright certificate of the USSR No. 1500308, cl. A 61 K 7/16, 1989.

4. Copyright certificate of the USSR No. 1657188, cl. A 61 K 7/16, 1991.

5. RF patent No. 2012329, cl. A 61 K 7/16, 1991.

6. RF patent No. 2112501, cl. A 61 K 7/16, 1998.

7. Copyright certificate of the USSR No. 1644961, cl. A 61 K 7/16, 1991.

8. RF patent No. 2119328, cl. A 61 K 7/16, 1998.

9. Copyright certificate of the USSR No. 942756, cl. A 61 K 7/16, 1982 (prototype).

Claims (2)

1. Toothpaste containing abrasive material, a water-retaining substance, sodium carboxymethyl cellulose, a surfactant, a fluorine source, a plant extract, a preservative, a sweetener, perfume and water, characterized in that it additionally contains calcium carbonate or glycerophosphate and dye, and in it contains silicon dioxide as an abrasive material, glycerol or sorbitol as a water-retaining substance, sodium lauryl sulfate as a surfactant, and n Trier fluoride or monofluorophosphate, as a plant extract - aqueous extract of Siberian larch resin, as a sweetener - saccharin or xylitol in the following ratio, wt.%: Silica 17.0-25.0 Glycerin or sorbitol 24.0-32.5 Sodium carboxymethyl cellulose 0.6-2.0 Sodium Lauryl Sulfate 0.5-2.0 Sodium fluoride or sodium monofluorophosphate 0.2-0.8 Calcium carbonate or calcium glycerophosphate 0.8-1.2 Siberian Larch Resin Extract 0-7.0 Preservative 0.3-0.5 Saccharin or Xylitol 0.05-0.2 Fragrance 0.6-1.5 Food color 0.002-0.01 Water Else 2. Toothpaste according to claim 1, characterized in that as a preservative it contains propyl or methyl esters of paraoxybenzoic acid or sodium benzoate.