CN107468631A - Fish scale collagen biological toothpaste - Google Patents
Fish scale collagen biological toothpaste Download PDFInfo
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- CN107468631A CN107468631A CN201710818630.3A CN201710818630A CN107468631A CN 107468631 A CN107468631 A CN 107468631A CN 201710818630 A CN201710818630 A CN 201710818630A CN 107468631 A CN107468631 A CN 107468631A
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- fish scale
- toothpaste
- collagen
- enzyme
- hydroxyapatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses a kind of fish scale collagen biological toothpaste, contain fish scale extract and nano zine oxide in its toothpaste component, wherein by weight percentage, fish scale extract includes 40% 50% collagen and 50% 60% hydroxyapatite.The biological toothpaste of the present invention can reach the multi-effect in healthy brilliant white, removal bacterial plaque, improvement gum problem, prevention decayed tooth, halitosis, periodontosis.
Description
Technical field
The present invention relates to field of toothpaste, and in particular to a kind of fish scale collagen biological toothpaste.
Background technology
First, tooth FAQs：
Bacterial plaque：The micropopulation being adhered on dental surface or other soft tissues of oral cavity.Typically by a large amount of bacteriums, carefully
Intercellular substance, a small amount of leucocyte, Exfoliative cells and food scraps etc. form.Bacterium meeting in bacterial plaque and remain in oral cavity
In food acid reaction occurs, damage enamel, in addition, bacterial plaque is easy to combine to form calculus dentalis with other calcified materials, when
When calculus dentalis overstocks more, the symptoms such as gum redness, bleeding, atrophy just occur, trigger chronic inflammation, invade parodontium,
Cause periodontitis, cause tooth mobility and come off.
Periodontosis：Periodontal is tooth supporting tissue, including gum, cementum, periodontal ligament and alveolar bone, the disease of periodontosis
Because mostly due to the bacterial plaque of part, tartar, calculus dentalis, food impaction, partly can be by whole body system caused by ill fitting prosthesis etc.
Caused by disease.
Halitosis：Halitosis is broadly divided into two big types, first, halitosis caused by internal factor is lacked of proper care.Second, oral bacteria or disease
Halitosis caused by disease, such as carious tooth, gingivitis, periodontitis etc..
It is other：The reasons why oral bacteria makes us fearing is exactly to have abundant capillary in oral cavity, and bacterium enters blood capillary
Pipe, will soon be diffused into whole body everywhere.It has been found that the frequent bleeding in oral cavity, it is not easy to stop, precisely due to oral cavity blood capillary
The reason for pipe is extremely abundant.Bacterium in oral cavity wound easily enters in vivo.It is most readily accessible into internal bacterium
Human organ is exactly heart, and enters the bacterium of heart, can rapidly be sent to body everywhere, if at this moment immunity is very for body
Difference, various complication can be triggered at once.This be also why some emergent medicines can be placed on it is sublingual come first-aid patients.
Up to more than 80%-90% people, which is substantially all, more or less has oral cavity defect.Women after climacteric due to
Salivary secretion can be reduced, it is easier to obtain mouth disease.If bacterium reaches lung, bronchitis can be caused, pulmonary emphysema, reach bone
Bone will cause arthritis and osteoporosis etc..There is the pregnant woman of mouth disease, bacterium can reach placenta by blood vessel, invade uterus
Inner membrance, inflammation of uterus is caused, so as to trigger miscarriage.Male with periodontitis, property erectile dysfunction are no periodontitis males
Twice.All and inflammation-related, inflammation pathogenic factor is main precisely due to bacterial virus is invaded, and oral cavity is thin for all diseases
The main path of bacterium poisoning intrusion, so oral health management can not be ignored really.
2nd, the function of conventional toothpaste
Conventional toothpaste is with the cleaning that rubs, and it is clearly major design to make oral sensation, without too many scientific and technological content.In at present
The toothpaste that state uses is divided into " ordinary toothpaste, fluoride dental cream, medicated toothpaste " three major types, is summarized as follows：
1. ordinary toothpaste：What is beaten is exactly price war, without special function demand.
2. fluoride dental cream：Fluorine is a kind of chronic noxious material, and fluorine does not participate in metabolism in vivo, can accumulate in vivo always
It is tired, when fluorine intake is excessive, fluorosis of bone can be caused.Fluorine has been regarded as micro with genotoxic potential by the World Health Organization
Element, and the trace element such as lead mercury come same location.By national regulation, add fluorine toothpaste free fluorine should 400-1200ppm it
Between, need it is specifically intended that the unsuitable for children before 3-4 year uses, because 1/8-1/4 toothpaste may swallow stomach by them
In.
3. medicated toothpaste：On the basis of ordinary toothpaste plus a certain proportion of medicine is exactly that (such as Yunnan is white for medicated toothpaste
Medicine toothpaste), by the effect of medicine when brushing teeth, bacterial plaque is reduced, so as to play a part of anti-dental caries and periodontosis.At present, medicine
Favored by people thing toothpaste pole.But medicated toothpaste also has its unfavorable aspect, first, toothpaste is gargled in the intraoral short time
Go out, make medicine be difficult to play drug effect.Second, drug dose must avoid stimulating intraoral soft tissue, thus can not bring up to enough
Valid density.Third, the effect of toothpaste in itself, is often hindered or limited by morphological feature by intraoral dirt, thus it is difficult to reach
The region really fallen ill.Fourth, the medicine in toothpaste, often occurs other chemical changes long because of standing time, loses original
Drug effect, Chang Yin is unsuitable for being put into toothpaste active drug with peculiar smell again.Fifth, medicated toothpaste also has drug resistance problems, it is long
Phase uses the resistance to the action of a drug that can cause oral bacteria.More than a variety of factors show, medicated toothpaste should not long-term single use, medicine tooth
Cream is a kind of good imagination, but the effect that be really achieved prevention stomatopathy needs to make some further investigations.
The content of the invention
In view of this, in order to solve the above technical problems, it is an object of the invention to propose a kind of to have new functionalized tooth
Cream.
Used technical scheme is：
A kind of fish scale collagen biological toothpaste, contain fish scale extract and nano zine oxide in its toothpaste component, wherein
By weight percentage, fish scale extract includes 40%-50% collagen and 50%-60% hydroxyapatite.
Hydroxyapatite (HAp) is a kind of calcium phosphate compound, is the main inorganic composition of skeleton tissue, accounting is about
60%-70%, because hydroxyl squama lime stone and skeleton composition and structure are basically identical, there is splendid osteoconductive and bone knot
Conjunction ability, without any toxicity and side effects, without carcinogenic doubt, therefore it is widely used in human body hard tissue reparation and sclerotin packing material.
In the enamel of tooth and ivory, hydroxyapatite accounting is up to 90% and 70%, and particle diameter is smaller, and activity is got over
Height, high activity hydroxyapatite have again the mending function of calcification to tooth, and the crystal grain of hydroxyapatite is thinner, and bioactivity is got over
Height, into after in vivo, calcium and the phosphorus material surface that can dissociate are systemically absorbed, and grow new tissue, therefore by work(
Energy property toothpaste is as high-quality additive.But the excessive hydroxylapatite powder of particle diameter only has the ability of friction decontamination, does not have
Maintenance function.
Hydroxyapatite can primarily serve repair teeth surface scratches, the fine hole of repair teeth, prevention in this toothpaste
The effect of decayed tooth.
Collagen accounts for the 30% of human body protein total amount, is distributed mainly in connective tissue, is composition bone, soft
The important matrix of bone, blood vessel, skin etc., the collagen of human body in itself are synthesized by the fibroblast of skin corium, but with year
The increase in age and the oxidation of free radical, collagen can change and gradually be lost in, and normal human is lost in 1% per annual meeting
Collagen so that appearance age of skin, which increases, to be produced the agings such as relaxation, wrinkle and shows picture, and in-vivo tissue also can be because of collagen
The loss of albumen and function is gradually degenerated and aging.
The effect of what collagen was most attracted attention is its " anti-aging ", collagen can be effectively improved elasticity of skin, comfort
Flat microgroove and compact pore, in commercially available aging products, nearly all there is collagen figure, in addition, collagen also have it is anti-
Osteoporosis, arthritis is relaxed, treatment is ached, and improves color development, mitigation pressure and other effects.The collagen of high-quality short chain, which has, to be promoted
Enter the ability of human body collagen synthesis hyperplasia itself, therefore there is the work of maintenance and supplement to cartilaginous tissues such as gum, gums
With helpful to gingival lesions or gingival atrophy.
Collagen can primarily serve maintenance gum in this toothpaste, supplement gingiva tissue, collagen, maintain gum to be good for
The effect of health.
Zinc is the required mine trace element of human body institute, is also often added in various dynamic feeds, zinc raw material is made into nanoscale oxygen
After changing zinc, because particle diameter changes, zinc oxide is set to possess huge surface-area effects, and with suppression mould, bacterium, virus, drop
Solve the ability of organic matter (deodorization).
By in the hydroxyapatite and collagen hole of nano zine oxide implantation fish scale extraction, chemical preservative is excluded
Addition, makes toothpaste corrupt, smelly, rotten, and the ability with antibacterial, sterilizing, with reference to fish scale hydroxyapatite and glue
Former albumen, make the product quality of the present invention superior, it is unusual.
Nano zine oxide can primarily serve deodorization, antibacterial, sterilizing, corrosion-resistant effect in this toothpaste.
Further, by weight percentage, it includes following component：Calcium carbonate 50%-60%；Fish scale extract
20%-30%, nano zine oxide 1%-3%, water 8%-15% and toothpaste substrate 1%-5%, wherein toothpaste substrate contain wetting
Agent and foaming agent.Wetting agent can account for the 20%-30% of toothpaste substrate.Calcium carbonate is the Main Ingredients and Appearance of toothpaste, plays friction and decontamination
Effect.One or more in wetting agent such as xylitol, polyethylene glycol, sorbierite, glycerine, primarily serving prevents toothpaste from drying
The effect being hardened.Foaming agent such as sldium lauryl sulfate, lauryl sodium sulfate, ammonium alkylsurfuric acid, 2- acyloxy key sodium sulfonates
In one or more, foaming agent, which mainly rises, promotes the foaming of toothpaste composition, dissolves the effect of dental surface dirt.
Further, fish scale collagen biological toothpaste also includes taste agent 1%-2%.Taste agent such as aromatic, sweet tea
Taste agent, Mint Essence, fruit essence, the one or more of cyclohexylamine sulfonic acid sodium.Primarily serve and cover halitosis, oral cavity smell increase
Mouthfeel or the effect clearly felt.So everyone can select toothpaste according to different tastes.
Further, the average grain diameter of the hydroxyapatite is less than less than 0.15 micron.It is micro- that average grain diameter is less than 0.15
Hydroxyapatite below rice can produce greater activity, and the small dentine that can penetrate into of particle diameter is with dental surface fine crack, reaching and filling up
The purpose of tooth fine handling scratches and wound, in addition, high activity hydroxyapatite has the ability that supplement tooth calcium ionic current loses, and
The color and luster caused by bacterial plaque is removed to precipitate.
Further, the collagen is the triple helix structure formed by the polypeptide chain of 1.5 nanometers of diameter.This hair
It is bright that the long-chain collagen of triple helix structure is changed into short chain victory peptide, collagen composition is smoothly passed through skin barrier and support
Up to skin corium.
Further, the fish scale extract is prepared via a method which：
A, clean fish scale is carried out into micro-nanoization by micro-nanoization equipment to crush；B, with flooding, residue is filtered；c、
The collagen aqueous solution that b steps extract out is digested, 60-80 DEG C of enzyme deactivation is heated to after enzymolysis；Enzyme used is alkaline egg
The above enzyme mixing of one or both of white enzyme, animal protease, trypsase, the pH scopes of used enzyme are 7-9, are obtained
Collagen；D, the b residues for walking to obtain are dried to obtain nanometer hydroxyapatite.
This preparation method without acid-base pretreatment, separating-purifying effect it is good and will not to the collagen polypeptide in fish scale and
Hydroxyapatite activity impacts.Existing micro-nano pulverizer in micro-nanoization equipment such as Chinese food plant equipment net.
Traditional hydroxyapatite is refined from ore, and collagen extracts from the poultry tissue such as ox, sheep, pig, chicken,
It is of the invention then be from the fish scale tissue of fish while obtain both materials, because fish scale is the cartilaginous tissue of organism, into
Part is easier the utilization that is absorbed by the body, and performance is more superior compared with conventional process material.
One layer is covered with fish skin by the calcareous hard a piece of wood serving as a brake to halt a carriage ectoskeleton formed, that is, fish scale or derived from fish scales thing, fish scale
It is the multifunction organization by evolution, in addition to pretending and maintaining fish body external form, most important function is exactly to protect fish body, is kept away
Exempt from infringement and the resist the disease of microorganism, the composition of fish scale has 50%-60% hydroxyl squama lime stone, 40%-50% collagen
Albumen；The hydroxyapatite extracted via fish scale has higher bioactivity and affinity, has again calcification to repair to tooth
Function is mended, is the preferably raw doctor's material of orthopaedics and dentistry.Collagen in fish scale is that a kind of non-aqueous capacitive contains glycoprotein,
It is the key protein for forming tissue.
Because fish scale is obtained from piscine organism body, dry and then Ordinary pulverization is in cotton-wool sprills, because collagen wins peptide
Rich content, it is difficult to reach size further tinyization through Ordinary pulverization, in addition to fishlike smell, easily grown because nutritious
Bacterium, therefore, hydroxyapatite and collagen are extracted from fish scale, need to be milled to micro/nano level first on particle diameter
Not, so as to preparing satisfactory fish scale collagen and hydroxyapatite.
The production method of fish scale collagen biological toothpaste of the present invention, comprises the following steps：Will be each in addition to calcium carbonate
Component is sufficiently mixed, and stirring inflates it into uniform glue；Then addition calcium carbonate, which is sufficiently stirred, is made lotion；Lotion is passed through
Grinding, makes various components further be uniformly dispersed；Finally vacuumizing degassing turns into toothpaste.
To sum up, the beneficial effects of the present invention are：
The biological toothpaste of the present invention can reach healthy brilliant white, remove bacterial plaque, improve gum problem, prevention decayed tooth, mouth
Multi-effect in smelly, periodontosis.
Embodiment
The present invention is further described below by embodiment, but is not limitation of the present invention.
Unless stated otherwise, the content of following components uses percentage by weight.
Embodiment 1
A kind of fish scale collagen biological toothpaste, it includes following component：Calcium carbonate 60%；Fish scale extract 20%, receive
Rice zinc oxide 3%, water 10%, toothpaste substrate 5% and taste agent 2%；Wherein toothpaste substrate contains wetting agent 20% and foaming agent
80%, fish scale extract includes 45% collagen and 55% hydroxyapatite.The average grain diameter of hydroxyapatite is less than
Less than 0.15 micron；Collagen is the triple helix structure formed by the polypeptide chain of 1.5 nanometers of diameter.
Fish scale extract is prepared via a method which：
A, clean fish scale is carried out into micro-nanoization by micro-nanoization equipment to crush；B, with flooding, residue is filtered；c、
The collagen aqueous solution that extracts out of b steps is digested, 70 DEG C of enzyme deactivations 10 minutes are heated to after 50 DEG C of enzymolysis, enzymolysis；Institute
Enzyme is that one or both of alkali protease, animal protease, the trypsase above enzyme mix, the pH of used enzyme
Scope is 8.1-8.2, obtains collagen；D, the b residues for walking to obtain are dried to obtain nanometer hydroxyapatite.
The production method of fish scale collagen biological toothpaste, comprises the following steps：Each component in addition to calcium carbonate is filled
Divide mixing, stirring inflates it into uniform glue；Then addition calcium carbonate, which is sufficiently stirred, is made lotion；Lotion is ground,
Various components are made further to be uniformly dispersed；Finally vacuumizing degassing turns into toothpaste.
Embodiment 2
A kind of fish scale collagen biological toothpaste, it includes following component：Calcium carbonate 50%；Fish scale extract 30%, receive
Rice zinc oxide 2%, water 11%, toothpaste substrate 5% and taste agent 2%；Wherein toothpaste substrate contains wetting agent 25% and foaming agent
75%, fish scale extract includes 45% collagen and 55% hydroxyapatite.The average grain diameter of hydroxyapatite is less than
Less than 0.15 micron；Collagen is the triple helix structure formed by the polypeptide chain of 1.5 nanometers of diameter.
Fish scale extract is prepared via a method which：
A, clean fish scale is carried out into micro-nanoization by micro-nanoization equipment to crush；B, with flooding, residue is filtered；c、
The collagen aqueous solution that extracts out of b steps is digested, 80 DEG C of enzyme deactivations 10 minutes are heated to after 60 DEG C of enzymolysis, enzymolysis；Institute
Enzyme is that one or both of alkali protease, animal protease, the trypsase above enzyme mix, the pH of used enzyme
Scope is 8.5-8.6, obtains collagen；D, the b residues for walking to obtain are dried to obtain nanometer hydroxyapatite.
The production method of fish scale collagen biological toothpaste is with reference to embodiment 1.
Embodiment 3
A kind of fish scale collagen biological toothpaste, it includes following component：Calcium carbonate 55%；Fish scale extract 25%, receive
Rice zinc oxide 2%, water 14%, toothpaste substrate 2% and taste agent 2%；Wherein toothpaste substrate contains wetting agent 30% and foaming agent
70%, fish scale extract includes 45% collagen and 55% hydroxyapatite.The average grain diameter of hydroxyapatite is less than
Less than 0.15 micron；Collagen is the triple helix structure formed by the polypeptide chain of 1.5 nanometers of diameter.
Fish scale extract is prepared via a method which：
A, clean fish scale is carried out into micro-nanoization by micro-nanoization equipment to crush；B, with flooding, residue is filtered；c、
The collagen aqueous solution that extracts out of b steps is digested, 75 DEG C of enzyme deactivations 10 minutes are heated to after 56 DEG C of enzymolysis, enzymolysis；Institute
Enzyme is that one or both of alkali protease, animal protease, the trypsase above enzyme mix, the pH of used enzyme
Scope is 7.8-7.9, obtains collagen；D, the b residues for walking to obtain are dried to obtain nanometer hydroxyapatite.
The production method of fish scale collagen biological toothpaste is with reference to embodiment 1.
Embodiment 4
In order to verify the effect of toothpaste of the present invention, it is further elaborated with reference to clinical test, this experiment is from real
Apply the toothpaste of a 1-3.
(1) tested crowd：
300 subjects with the periodontitis caused by bacterial plaque of selection carry out canker sore and recover checking test.
(2) test method：All subjects use toothpaste any in embodiment 1-3 respectively to brush a tooth sooner or later daily, often
Secondary 3 minutes, adhere to using 2 months.
(3) result of the test：
The bacterial plaque of 300 subjects is removed, and periodontitis is substantially improved.And sent out by the observation of 2 months
It is existing, the dental health brilliant white of subject while there is the multi-effects such as prevention decayed tooth, halitosis, periodontosis.
Those listed above is a series of to describe illustrating only for possible embodiments of the invention in detail,
They simultaneously are not used to limit the scope of the invention, all equivalent embodiments made without departing from skill spirit of the present invention or change
It should be included in the scope of the protection.
Claims (6)
1. a kind of fish scale collagen biological toothpaste, it is characterised in that contain fish scale extract and nano oxygen in its toothpaste component
Change zinc, wherein by weight percentage, fish scale extract includes 40%-50% collagen and 50%-60% hydroxyl phosphorus
Lime stone.
2. fish scale collagen biological toothpaste according to claim 1, it is characterised in that by weight percentage, it is wrapped
Include following component：Calcium carbonate 50%-60%；Fish scale extract 20%-30%, nano zine oxide 1%-3%, water 8%-15% and
Toothpaste substrate 1%-5%, wherein toothpaste substrate contain wetting agent and foaming agent.
3. fish scale collagen biological toothpaste according to claim 2, it is characterised in that also including taste agent 1%-2%.
4. fish scale collagen biological toothpaste according to claim 1, it is characterised in that the hydroxyapatite is averaged
Particle diameter is less than less than 0.15 micron.
5. fish scale collagen biological toothpaste according to claim 1, it is characterised in that the collagen is by diameter
The triple helix structure that 1.5 nanometers of polypeptide chain is formed.
6. fish scale collagen biological toothpaste according to claim 1, it is characterised in that the fish scale extract passes through such as
It is prepared by lower section method：
A, clean fish scale is carried out into micro-nanoization by micro-nanoization equipment to crush；B, with flooding, residue is filtered；C, by b
The collagen aqueous solution enzymolysis extracted out is walked, 60-80 DEG C of enzyme deactivation is heated to after enzymolysis；Enzyme used is basic protein
One or both of enzyme, animal protease, trypsase above enzyme mix, and the pH scopes of used enzyme are 7-9, obtain glue
Former albumen；D, the b residues for walking to obtain are dried to obtain nanometer hydroxyapatite.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710818630.3A CN107468631A (en) | 2017-09-12 | 2017-09-12 | Fish scale collagen biological toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710818630.3A CN107468631A (en) | 2017-09-12 | 2017-09-12 | Fish scale collagen biological toothpaste |
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| CN107468631A true CN107468631A (en) | 2017-12-15 |
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ID=60584462
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403540A (en) * | 2018-02-28 | 2018-08-17 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing tuna active peptides toothpaste |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| TWI721592B (en) * | 2019-10-08 | 2021-03-11 | 王滋林 | Natural particulate composition |
| CN113545998A (en) * | 2020-04-24 | 2021-10-26 | 上海睿固生物技术有限公司 | Hydroxyapatite and collagen composition and application thereof in removing nevus, removing freckles, reducing pigmentation and whitening |
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| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| CN101724677A (en) * | 2009-12-15 | 2010-06-09 | 武汉普赛特膜技术循环利用有限公司 | Method for extracting collagen polypeptide and hydroxyapatite in fish scales by cooking hot extrusion |
| CN104546519A (en) * | 2015-01-26 | 2015-04-29 | 莫治玲 | Toothpaste |
| CN105769696A (en) * | 2016-04-15 | 2016-07-20 | 山东天欣生物科技有限公司 | Chinese herbal toothpaste containing fish collagen protein peptide |
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- 2017-09-12 CN CN201710818630.3A patent/CN107468631A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256123A (en) * | 1998-12-09 | 2000-06-14 | 孟祥才 | Hydroxyl apatite toothpaste with dental-filling function |
| CN101724677A (en) * | 2009-12-15 | 2010-06-09 | 武汉普赛特膜技术循环利用有限公司 | Method for extracting collagen polypeptide and hydroxyapatite in fish scales by cooking hot extrusion |
| CN104546519A (en) * | 2015-01-26 | 2015-04-29 | 莫治玲 | Toothpaste |
| CN105769696A (en) * | 2016-04-15 | 2016-07-20 | 山东天欣生物科技有限公司 | Chinese herbal toothpaste containing fish collagen protein peptide |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403540A (en) * | 2018-02-28 | 2018-08-17 | 磐安县派普特生物科技有限公司 | A kind of preparation method containing tuna active peptides toothpaste |
| TWI721592B (en) * | 2019-10-08 | 2021-03-11 | 王滋林 | Natural particulate composition |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| CN113545998A (en) * | 2020-04-24 | 2021-10-26 | 上海睿固生物技术有限公司 | Hydroxyapatite and collagen composition and application thereof in removing nevus, removing freckles, reducing pigmentation and whitening |
| CN113545998B (en) * | 2020-04-24 | 2023-09-19 | 上海睿星医疗器材有限公司 | Hydroxyapatite and collagen composition and application thereof in removing nevus, removing freckles, reducing pigmentation and whitening |
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Application publication date: 20171215 |
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