CN110859777A - Collagen toothpaste - Google Patents

Abstract

The invention provides collagen toothpaste, which is characterized by comprising the following components: 0.01-0.2 wt% of collagen, 1-5 wt% of thickening agent, 20-50 wt% of humectant, 0.1-0.8 wt% of sweetening agent, 0.1-1 wt% of preservative, 10-50 wt% of abrasive, 1-2.5 wt% of foaming agent, 0.5-2 wt% of essence and acid-base regulator, wherein the content of the acid-base regulator is 0.01-0.1% of the collagen content, and the balance of water. The collagen added in the collagen toothpaste provided by the invention can promote the absorption of calcium and strengthen the oxidation resistance of teeth; in view of the effects of stopping bleeding of the collagen and repairing oral cavity micro-injury, the toothpaste can protect oral cavity intima, repair oral mucosa, prevent oral ulcer, repair gum injury and relieve gum bleeding; especially when the collagen has a triple helix structure, the effect is better.

Description

Collagen toothpaste

Technical Field

The invention relates to the field of daily chemical products, in particular to collagen toothpaste.

Background

In recent years, the oral health care consciousness of people is gradually improved, and the toothpaste is used as an important oral cleaning and nursing article for cleaning teeth and maintaining oral hygiene and is closely related to the daily life of people. At present, the toothpaste appearing in the market of China can be roughly divided into two categories of common toothpaste and functional toothpaste. The common toothpaste can enhance the friction force of tooth brushing, help to remove food scraps, soft dirt and dental plaque, help to eliminate or relieve the peculiar smell of the oral cavity and make the breath fresh. If functional components such as fluoride, traditional Chinese medicine components, chemical components for controlling tartar and resisting dentin sensitivity and the like are added in the preparation of the toothpaste body, the toothpaste respectively has the effects of preventing caries, reducing dental plaque, resisting dentin sensitivity, inhibiting the formation of tartar and the like, and has the basic functions of toothpaste, and the toothpaste also has the effects of assisting in preventing or relieving certain oral diseases and symptoms and promoting oral health.

Collagen is a natural biological polymer material, and the rapid hemostasis effect can be realized by utilizing the performance of promoting the contraction of blood vessels, the activation of blood platelets and the starting of a blood coagulation system. The natural high-grade structure of the collagen is the basis of the blood coagulation ability of the collagen, when the collagen acts on the wound surface, the collagen at the initial stage adsorbs blood platelets, interacts with blood coagulation factors and causes the blood platelets to polymerize, thereby playing the role of stopping blood; the damage of the platelet can release various active substances such as growth factors and the like, induce the activity of fibroblasts, activate and regulate the functions of different blood cells, thereby achieving the effects of stopping bleeding and repairing oral cavity micro-damage. In addition, the collagen can promote the absorption of calcium and strengthen the antioxidation of the teeth.

Disclosure of Invention

Aiming at the problems possibly existing in the traditional toothpaste, the invention aims to provide a collagen toothpaste which is characterized by comprising the following components: 0.01-0.2 wt% of collagen, 1-5 wt% of thickening agent, 20-50 wt% of humectant, 0.1-0.8 wt% of sweetening agent, 0.1-1 wt% of preservative, 10-50 wt% of abrasive, 1-2.5 wt% of foaming agent, 0.5-2 wt% of essence and acid-base regulator, wherein the content of the acid-base regulator is 0.01-0.1% of the collagen content, and the balance of water.

The collagen added in the collagen toothpaste provided by the invention can promote the absorption of calcium and strengthen the oxidation resistance of teeth; in view of the effects of stopping bleeding of the collagen and repairing oral cavity micro-injury, the toothpaste can protect oral cavity intima, repair oral mucosa, prevent oral ulcer, repair gum injury and relieve gum bleeding; especially when the collagen has a triple helix structure, the effect is better.

Detailed Description

The collagen toothpaste is characterized by comprising the following components: 0.01-0.2 wt% of collagen, 1-5 wt% of thickening agent, 20-50 wt% of humectant, 0.1-0.8 wt% of sweetening agent, 0.1-1 wt% of preservative, 10-50 wt% of abrasive, 1-2.5 wt% of foaming agent, 0.5-2 wt% of essence and acid-base regulator, wherein the content of the acid-base regulator is 0.01-0.1% of the collagen content, and the balance of water.

Preferably, the preparation method of the collagen toothpaste comprises the following steps:

(1) uniformly dispersing a thickening agent in a humectant to obtain a pre-dispersion liquid;

(2) dissolving sweetener, antiseptic, pH regulator and collagen in water, and stirring to obtain pre-dissolved solution;

(3) stirring and mixing the pre-dissolved solution obtained in the step (2), the foaming agent and the balance of water; slowly adding the pre-dispersion liquid obtained in the step (1) to further diffuse and swell the pre-dispersion liquid into uniform glue;

(4) aging the glue obtained in the step (3), adding the abrasive and the essence, and fully stirring by a paste making machine;

(5) and (4) grinding, degassing and vacuumizing the substance obtained in the step (4) to obtain the toothpaste body.

Preferably, the collagen has a triple helix structure.

The thickening agent can be any thickening agent adopted in the field, and preferably, the thickening agent is one or more of sodium carboxymethylcellulose, carrageenan, xanthan gum and hydroxyethyl cellulose.

The humectant can be any humectant used in the art, and preferably, the humectant is one or more of glycerin, sorbitol, polyethylene glycol, and propylene glycol.

The preservative may be any preservative used in the art, preferably the preservative is one or more of parabens (parabens), gallic acid ester, ascorbyl palmitate.

The pH regulator can be any pH regulator in the field, and preferably, the pH regulator is one or more of citric acid, tartaric acid, malic acid, acetic acid, hydrochloric acid, sodium citrate and potassium citrate.

The foaming agent can be any foaming agent in the field, and preferably, the foaming agent is one or more of sodium lauryl sulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl propyl betaine and alkyl glycoside.

The abradant can be any abradant in the field, preferably, the abradant is one or more of calcium carbonate, silicon dioxide and calcium hydrophosphate.

The sweetening agent can be any sweetening agent in the field, and preferably, the sweetening agent is one or more of sorbitol, saccharin sodium, xylitol, fructose, maltose, aspartame, sucralose and acesulfame potassium.

The essence can be any essence in the field, and preferably, the essence is one or a combination of several of lemon, sweet orange, apple, blueberry, spearmint and mint.

The present invention is described in detail below with reference to specific examples, which should be construed as merely illustrative of a collagen dentifrice and a method for preparing the same, and not as a limitation to the scope of the present invention.

Example 1

(1) 10g of sodium carboxymethylcellulose was uniformly dispersed in 400g of glycerin, and sufficiently stirred to obtain a predispersion.

(2) 1g of acesulfame potassium, 1g of sodium p-hydroxybenzoate, 0.01g of sodium citrate and 0.1 g% of type I collagen were dissolved in 10g of water, and sufficiently stirred to obtain a pre-dissolved solution.

(3) And (3) stirring and mixing the pre-dissolved solution obtained in the step (2), 10g of sodium lauryl sulfate and 362.89g of water, and slowly adding the pre-dispersed solution to further diffuse and swell the pre-dispersed solution into uniform glue.

(4) And (4) aging the glue obtained in the step (3), adding 100g of calcium carbonate, 3g of lemon essence and 2g of apple essence, and fully stirring by using a paste making machine.

(5) And (4) grinding the substance obtained in the step (4), degassing and vacuumizing to obtain the toothpaste body.

The toothpaste can effectively prevent oral cavity intimal injury.

Example 2

(1) 20g of carrageenan and 30g of xanthan gum are uniformly dispersed in 500g of propylene glycol, and fully stirred to obtain a pre-dispersion liquid.

(2) 2g of saccharin sodium, 1g of fructose, 1g of potassium gallate, 0.002g of citric acid, 0.002g of potassium citrate and 0.5g of type III collagen were dissolved in 10g of water, and the resulting solution was stirred sufficiently to obtain a pre-dissolved solution.

(3) And (3) stirring and mixing the pre-dissolved solution obtained in the step (2), 13g of sodium lauroyl sarcosinate, 12g of sodium lauroyl glutamate and 102.50 g of water, and slowly adding the pre-dispersed solution to further diffuse and swell the pre-dispersed solution into uniform glue.

(4) And (4) aging the glue obtained in the step (3), adding 300g of silicon dioxide, 3g of sweet orange and 5g of blueberry essence, and fully stirring by using a paste making machine.

(5) And (4) grinding the substance obtained in the step (4), degassing and vacuumizing to obtain the toothpaste body.

The toothpaste has good effect on gingival injury.

Example 3

(1) 40g of hydroxyethyl cellulose is uniformly dispersed in 200g of sorbitol, and the predispersion is obtained by fully stirring.

(2) 3g of xylitol and 2g of maltose, 2g of sodium ascorbyl palmitate, 1g of sodium gallate, 0.001g of acetic acid, 0.005g of malic acid and 1g of type II collagen were dissolved in 10g of water, and the resulting solution was thoroughly stirred to obtain a pre-dissolved solution.

(3) And (3) stirring and mixing the pre-dissolved solution obtained in the step (2), 18g of cocoyl propyl betaine and 208g of water, and slowly adding the pre-dispersed solution to further diffuse and swell the pre-dispersed solution into uniform glue.

(4) And (4) ageing the glue obtained in the step (3), adding 200g of calcium carbonate, 300g of calcium hydrophosphate and 15g of spearmint essence, and fully stirring by using a paste making machine.

(5) And (4) grinding the substance obtained in the step (4), degassing and vacuumizing to obtain the toothpaste body.

The toothpaste has good effect of repairing oral mucosa.

Example 4

(1) 30g of xanthan gum was uniformly dispersed in 300g of polyethylene glycol, and sufficiently stirred to obtain a predispersion.

(2) 5g of aspartame, 3g of sucralose, 25g of potassium p-hydroxybenzoate, 0.008g of tartaric acid, 0.002g of hydrochloric acid and 2g of type I collagen are dissolved in 10g of water, and the mixture is fully stirred to obtain a pre-dissolved solution.

(3) And (3) stirring and mixing the pre-dissolved solution obtained in the step (2), 13g of alkyl glycoside and 210g of water, and slowly adding the pre-dispersed solution to further diffuse and swell the pre-dispersed solution into uniform glue.

(4) And (4) ageing the glue obtained in the step (3), adding 400g of silicon dioxide and 2g of mint essence, and fully stirring by using a paste making machine.

(5) And (4) grinding the substance obtained in the step (4), degassing and vacuumizing to obtain the toothpaste body.

The toothpaste can relieve gingival bleeding to a certain extent.

Claims (3)

1. The collagen toothpaste is characterized by comprising the following components: 0.01-0.2 wt% of collagen, 1-5 wt% of thickening agent, 20-50 wt% of humectant, 0.1-0.8 wt% of sweetening agent, 0.1-1 wt% of preservative, 10-50 wt% of abrasive, 1-2.5 wt% of foaming agent, 0.5-2 wt% of essence and acid-base regulator, wherein the content of the acid-base regulator is 0.01-0.1% of the collagen content, and the balance of water.

2. The collagen toothpaste as claimed in claim 1, wherein the preparation method comprises the following steps:

(1) uniformly dispersing a thickening agent in a humectant to obtain a pre-dispersion liquid;

(2) dissolving sweetener, antiseptic, pH regulator and collagen in water, and stirring to obtain pre-dissolved solution;

(3) stirring and mixing the pre-dissolved solution obtained in the step (2), the foaming agent and the balance of water; slowly adding the pre-dispersion liquid obtained in the step (1) to further diffuse and swell the pre-dispersion liquid into uniform glue;

(4) aging the glue obtained in the step (3), adding the abrasive and the essence, and fully stirring by a paste making machine;

(5) and (4) grinding, degassing and vacuumizing the substance obtained in the step (4) to obtain the toothpaste body.

3. A collagen dentifrice as claimed in claim 1 or claim 2 wherein the collagen has a triple helix structure.