CN106798696A - A kind of biological toothpaste for nursing and its production method containing recombination human source collagen - Google Patents
A kind of biological toothpaste for nursing and its production method containing recombination human source collagen Download PDFInfo
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- CN106798696A CN106798696A CN201710119677.0A CN201710119677A CN106798696A CN 106798696 A CN106798696 A CN 106798696A CN 201710119677 A CN201710119677 A CN 201710119677A CN 106798696 A CN106798696 A CN 106798696A
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- human source
- recombination human
- source collagen
- toothpaste
- collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a kind of biological toothpaste for nursing containing recombination human source collagen, including following percentage by weight raw material：Recombination human source collagen 0.01~0.1%, calcium carbonate 30~50%, glycerine 25~48%, sodium carboxymethylcellulose 1~3%, laruyl alcohol sodium sulfovinate 1.8~3.2%, preservative（One or more of parabens）0.1~0.8%, peppermint oil 1~2%, carrot extractive juice 0.01~0.02%；Balance of water.This several components matching is used, especially plus the effect of active component recombination human source collagen and carrot extractive juice, being capable of the effectively tooth such as prevention of gingivitis, canker sore, mouth disease, recombination human source collagen can quickly repair oral cavity micro-damage, the presence of carrot extractive juice can not only aid in repair damage, also have concurrently moisturizing, it is antibacterial, remove oral peculiar smell the effects such as.Toothpaste of the invention is conducive to oral health, safe and harmless.
Description
Technical field
The present invention relates to daily chemical product field, and in particular to a kind of biological toothpaste for nursing containing recombination human source collagen
Formula and its production method.
Background technology
Toothpaste species in the market is various, and the biological active matter with nutrition health-care functions has been engendered in recent years
The toothpaste of matter, wherein the toothpaste of addition albumen active component is also a study hotspot.A kind of " oral cavity shield containing polyglutamic acid
Reason toothpaste and preparation method thereof "（Publication No.：CN106176299A）In add polyglutamic acid can be with nutrition oral cavity, whitening tooth
Tooth, balances flora, prevents oral problem, and the glutamic acid after its degraded is to tooth and the nutritious effect of gum." one kind contains fish glue
The Chinese herbal toothpaste of former protein peptides "（Publication No.：CN105769696A）In with the addition of Isin glue collagen peptide, can promote calcium carbonate and
The absorption of calcium phosphate, reinforcing tooth it is anti-oxidant, can effectively repair oral cavity anabrosis, preventing canker sore, protect and repair tooth
Gum tissue loss, has good prevention and repair to the people with mouth disease.In existing market, collagen is added
Toothpaste it is considerably less, and that added in this patent is a kind of unique recombination human source collagen, its amino acid sequence and people
Body collagen, amino acid sequence appropriate section 100% is identical, does not have immunological rejection and allergic reaction to human body.
The content of the invention
The present invention provides a toothpaste containing unique recombination human source collagen active component, enables toothpaste to oral cavity
Play good biological maintenance action.
The technical solution adopted by the present invention is specially：A kind of biological toothpaste for nursing containing recombination human source collagen, including
The raw material of following percentage by weight：Recombination human source collagen 0.01~0.1%, calcium carbonate 30~50%, glycerine 25~48%, carboxylic
Sodium carboxymethylcellulose pyce（CMC-Na）1~3%, laruyl alcohol sodium sulfovinate 1.8~3.2%, preservative（Parabens is a kind of or many
Kind）0.1~0.8%, peppermint oil 1~2%, carrot extractive juice 0.01~0.02%；Balance of water.
Further, the biological toothpaste for nursing containing recombination human source collagen includes the original of following percentage by weight
Material：
Recombination human source collagen 0.01~0.02%, calcium carbonate 30~35%, glycerine 28~33%, sodium carboxymethylcellulose 1~
3%, laruyl alcohol sodium sulfovinate 1.8~3.2%, preservative（One or more of parabens）0.1~0.8%, peppermint oil 1~2%,
Carrot extractive juice 0.01~0.02%；Balance of water.
The production method of the biological toothpaste for nursing containing recombination human source collagen of the present invention, comprises the following steps：
（1）Sodium carboxymethylcellulose is dispersed in glycerine by formula is made homogeneous dispersion liquid A；
（2）Preservative, carrot extractive juice, recombination human source collagen is soluble in water, stir, obtain solution B；
（3）Solution B is added in dispersion liquid A, stirring inflates it into uniform glue；
（4）In step（3）Laruyl alcohol sodium sulfovinate is added in gained glue, after ageing, adds calcium carbonate and peppermint oil fully to stir
Mixing is into lotion；
（5）Lotion is ground, various particulates is further uniformly dispersed；
（6）Finally vacuumizing degassing turns into toothpaste.
The recombination human source collagen with bioactivity, is type III human collagen in the present invention, by long-term screening
Optimization, using escherichia expression system, the sequence in gene is optimized for escherichia expression system, and expression is formed
With extraordinary hydrophily and stability, its amino acid sequence and the phase of human collagen protein amino acid sequence appropriate section 100%
Together, therefore it is applied to human body and will not produces immunological rejection and allergic reaction, can be widely applied to biological medicine and cosmetic conduct
Industry, replenishing collagen being capable of the effectively tooth such as prevention of gingivitis, canker sore, mouth disease.It is preferred that according to patent《One kind weight
Group human-like collagen and its production method》（CN103122027B）Recombination human source collagen prepared by described method.
Calcium carbonate is white solid, tasteless, odorless.Calcium carbonate has two kinds of heavy and lightweight, and powdered whiting is by rock
Limestone in stone and calcite are crushed, grinding, refined form.Precipitated calcium carbonate is that calcium salt is dissolved in hydrochloric acid, then is passed through two
Carbonoxide, obtains precipitation of calcium carbonate.Precipitated calcium carbonate particle is thin, and light specific gravity can be used for toothpaste.It is used in inventive formulation
Rubbing agent.
Glycerine is achromaticity and clarification thick liquid, and odorless has warm sweet taste.Be widely used in medicine, food, tobacco, cosmetics,
The industries such as toothpaste, ink, coating, national defence, leather, printing and dyeing, synthetic resin, agricultural chemicals.It is used for wetting agent in inventive formulation.
Sodium carboxymethylcellulose for white or milky fibrous powder or particle, be widely used in food, medicine, daily use chemicals,
The industries such as printing and dyeing.It is used for adhesive in inventive formulation.
Laruyl alcohol sodium sulfovinate is white powder, there is characteristic odor, soluble in water, and foaming power is strong, foam is plentiful, pure white,
It is fine and closely woven, also excellent emulsifiability and washability.It is used for foaming agent in inventive formulation.
Parabens is a kind of milky to yellowish-brown powder, and odorless, tasteless, the broad spectrum activity generally acknowledged in the world is efficiently prevented
Rotten agent, is widely used in the fields such as the anti-corrosion of food, medicine and cosmetics.Edible is harmless.With excellent life
Thing degradation property.It is used for preservative in inventive formulation.
Peppermint oil is colourless or flaxen supernatant liquid, is to confer to a kind of indispensable composition of toothpaste cooling feeling,
There is special refrigerant fragrance, taste is just pungent, rear cool.It is used for spices in inventive formulation.
Containing a large amount of vitamins, nutrient, mineral matter etc. in carrot extractive juice, can anti-oxidant, improvement cavity interior ring
Border, depth nourishes mouth epithelial cells, and, removing oral peculiar smell antibacterial to oral cavity ecological environment beneficial bacterium, promotes bone and tooth
The healthy growth effect of tooth.
Technical scheme especially has effect following prominent.
1st, toothpaste of the present invention has good biological maintenance action, is mainly reflected in the biology during oral cavity micro-damage is repaired
In process.Human oral cavity mucous membrane is damaged, it is necessary to largely secrete human collagen albumen to repair.Toothpaste of the invention can be supplemented
Collagen needed for wound repair, reaches the quick purpose for repairing oral cavity micro-damage.In addition, dentine, gum and root of the tooth
And containing substantial amounts of collagen in oral mucosa, the toothpaste containing collagen being capable of effectively prevention of gingivitis, canker sore etc.
Tooth, mouth disease.
2nd, toothpaste of the present invention has good biological maintenance action, is also embodied in present invention employs recombination human source type III
Collagen material.General collagen is often using animal derived collagen as material, although with low cost, but
Cause collagen bioactivity very poor after chemical technology treatment, and easily cause human immunity rejection.Even if adopting
With human-like collagen, also tend to using NTx albumen.But NTx albumen composition is glue in human body skin mucous membrane
Fibrillation, and type III collagen composition is reticular fibre.In wound repair, type III collagen serves more crucial
Effect.The present invention has selected the type III collagen easily lacked in human body skin mucous membrane, dedicated for helping repair oral cavity
Micro-damage, with technical significant advantage, its effect is substantially better than the product as raw material using other collagens.
3rd, toothpaste of the present invention has good biological maintenance action, is also embodied in the formulation selection for adding carrot extractive juice
On.Multiple biological activities composition in carrot extractive juice, such as vitamin A, vitamin C, carrotene, multi mineral are oily, many
Sugar and fat etc., can provide abundant nutriment for the human body cell in injury tissue, it is directly utilized and is synthesized
Bioactivator needed for Proliferation, Differentiation, promotes it to repair and damages, further auxiliary collagen function.Carrot carries
Take liquid also have concurrently in itself moisturizing, it is antibacterial, remove oral peculiar smell the effects such as so that the adaptability of toothpaste of the present invention is wider, and effect is more
It is good.
Specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.05%, calcium carbonate 39%, glycerine 30%, sodium carboxymethylcellulose（CMC-Na）1%, laruyl alcohol sulphur
Acid esters sodium 2%, soluble metyl hydroxybenzoate 0.32%, peppermint oil 1.5%, carrot extractive juice 0.02%, balance of water.
Embodiment 2
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.1%, calcium carbonate 30%, glycerine 42%, sodium carboxymethylcellulose（CMC-Na）2%, laruyl alcohol sulphur
Acid esters sodium 2.5%, soluble metyl hydroxybenzoate 0.2%, soluble propylhydroxybenzoate 0.1%, peppermint oil 2%, carrot extractive juice 0.015%, surplus
It is water.
Embodiment 3
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.1%, calcium carbonate 43%, glycerine 45%, sodium carboxymethylcellulose（CMC-Na）1.2%, laruyl alcohol
Sodium sulfovinate 3%, soluble metyl hydroxybenzoate 0.32%, peppermint oil 2%, carrot extractive juice 0.02%, balance of water.
Embodiment 4
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.01%, calcium carbonate 45%, glycerine 30%, sodium carboxymethylcellulose（CMC-Na）2%, laruyl alcohol sulphur
Acid esters sodium 2%, soluble metyl hydroxybenzoate 0.35%, peppermint oil 1%, carrot extractive juice 0.015%, balance of water.
Embodiment 5
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.02%, calcium carbonate 33%, glycerine 30%, sodium carboxymethylcellulose（CMC-Na）2.3%, laruyl alcohol
Sodium sulfovinate 2.4%, nipagin A sodium 0.37%, peppermint oil 1.4%, carrot extractive juice 0.012%, balance of water.
Embodiment 6
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.015%, calcium carbonate 35%, glycerine 28%, sodium carboxymethylcellulose（CMC-Na）1%, laruyl alcohol
Sodium sulfovinate 3.2%, soluble metyl hydroxybenzoate 0.2%, soluble propylhydroxybenzoate 0.1%, peppermint oil 2%, carrot extractive juice 0.02%, surplus
It is water.
Embodiment 7
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.018%, calcium carbonate 30%, glycerine 33%, sodium carboxymethylcellulose（CMC-Na）3%, laruyl alcohol
Sodium sulfovinate 3%, soluble metyl hydroxybenzoate 0.12%, soluble propylhydroxybenzoate 0.08%, peppermint oil 1.7%, carrot extractive juice 0.018%,
Balance of water.
Embodiment 8
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.01%, calcium carbonate 33%, glycerine 32%, sodium carboxymethylcellulose（CMC-Na）2%, laruyl alcohol sulphur
Acid esters sodium 2%, soluble metyl hydroxybenzoate 0.18%, soluble propylhydroxybenzoate 0.02%, peppermint oil 1%, carrot extractive juice 0.015%, surplus
It is water.
Embodiment 9
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.04%, calcium carbonate 50%, glycerine 25%, sodium carboxymethylcellulose（CMC-Na）2%, laruyl alcohol sulphur
Acid esters sodium 1.8%, soluble metyl hydroxybenzoate 0.2%, soluble propylhydroxybenzoate 0.1%, peppermint oil 2%, carrot extractive juice 0.012%, surplus
It is water.
Embodiment 10
A kind of biological toothpaste for nursing containing recombination human source collagen, each component percentage by weight is as follows：
Recombination human source collagen 0.08%, calcium carbonate 30%, glycerine 48%, sodium carboxymethylcellulose（CMC-Na）2%, laruyl alcohol sulphur
Acid esters sodium 2%, soluble metyl hydroxybenzoate 0.15%, soluble propylhydroxybenzoate 0.08%, peppermint oil 1%, carrot extractive juice 0.02% is balance of
Water.
The production method of the toothpaste described in embodiment 1-10 is：
（1）Sodium carboxymethylcellulose is dispersed in glycerine by formula is made homogeneous dispersion liquid A；
（2）Preservative, carrot extractive juice, recombination human source collagen is soluble in water, stir, obtain solution B；
（3）Solution B is added in dispersion liquid A, stirring inflates it into uniform glue；
（4）In step（3）Laruyl alcohol sodium sulfovinate is added in gained glue, after ageing, adds calcium carbonate and peppermint oil fully to stir
Mixing is into lotion；
（5）Lotion is ground, various particulates is further uniformly dispersed；
（6）Finally vacuumizing degassing turns into toothpaste.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and can not limit invention,
Claims indicate the scope of the present invention, and the scope of the present invention is not pointed out in above-mentioned explanation, therefore, with the present invention
The suitable implication and scope of claims in any change, be all considered as being included within the scope of the claims.
Claims (3)
1. a kind of biological toothpaste for nursing containing recombination human source collagen, it is characterised in that the original including following percentage by weight
Material：
Recombination human source collagen 0.01~0.1%, calcium carbonate 30~50%, glycerine 25~48%, sodium carboxymethylcellulose 1~3%,
Laruyl alcohol sodium sulfovinate 1.8~3.2%, preservative（One or more of parabens）0.1~0.8%, peppermint oil 1~2%, recklessly
Radish extract solution 0.01~0.02%；Balance of water.
2. a kind of biological toothpaste for nursing containing recombination human source collagen according to claim 1, it is characterised in that including
The raw material of following percentage by weight：
Recombination human source collagen 0.01~0.02%, calcium carbonate 30~35%, glycerine 28~33%, sodium carboxymethylcellulose 1~
3%, laruyl alcohol sodium sulfovinate 1.8~3.2%, preservative（One or more of parabens）0.1~0.8%, peppermint oil 1~2%,
Carrot extractive juice 0.01~0.02%；Balance of water.
3. the production method of the biological toothpaste for nursing containing recombination human source collagen according to claim 1 and 2, its feature
It is to comprise the following steps：
（1）Sodium carboxymethylcellulose is dispersed in glycerine by formula is made homogeneous dispersion liquid A；
（2）Preservative, carrot extractive juice, recombination human source collagen is soluble in water, stir, obtain solution B；
（3）Solution B is added in dispersion liquid A, stirring inflates it into uniform glue；
（4）In step（3）Laruyl alcohol sodium sulfovinate is added in gained glue, after ageing, adds calcium carbonate and peppermint oil fully to stir
Mixing is into lotion；
（5）Lotion is ground, various particulates is further uniformly dispersed；
（6）Finally vacuumizing degassing turns into toothpaste.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710119677.0A CN106798696A (en) | 2017-03-02 | 2017-03-02 | A kind of biological toothpaste for nursing and its production method containing recombination human source collagen |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710119677.0A CN106798696A (en) | 2017-03-02 | 2017-03-02 | A kind of biological toothpaste for nursing and its production method containing recombination human source collagen |
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| CN106798696A true CN106798696A (en) | 2017-06-06 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983673A (en) * | 2015-06-26 | 2015-10-21 | 山西锦波生物医药股份有限公司 | Anti-HIV JB protein rectum gel preparation and preparation method thereof |
| CN110787288A (en) * | 2019-12-25 | 2020-02-14 | 郑州康金瑞健康产业有限公司 | Medical collagen oral ulcer protective gel and preparation method thereof |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| CN110960440A (en) * | 2019-12-27 | 2020-04-07 | 河北考力森生物科技有限公司 | Collagen mouthwash |
| CN113683681A (en) * | 2021-09-15 | 2021-11-23 | 山西锦波生物医药股份有限公司 | Recombinant I-type humanized collagen C1L3T, and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983673A (en) * | 2015-06-26 | 2015-10-21 | 山西锦波生物医药股份有限公司 | Anti-HIV JB protein rectum gel preparation and preparation method thereof |
| CN110787288A (en) * | 2019-12-25 | 2020-02-14 | 郑州康金瑞健康产业有限公司 | Medical collagen oral ulcer protective gel and preparation method thereof |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| CN110960440A (en) * | 2019-12-27 | 2020-04-07 | 河北考力森生物科技有限公司 | Collagen mouthwash |
| CN113683681A (en) * | 2021-09-15 | 2021-11-23 | 山西锦波生物医药股份有限公司 | Recombinant I-type humanized collagen C1L3T, and preparation method and application thereof |
| CN113683681B (en) * | 2021-09-15 | 2023-10-03 | 山西锦波生物医药股份有限公司 | Recombinant I-type humanized collagen C1L3T and preparation method and application thereof |
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Application publication date: 20170606 |