CN106176345A - A kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof - Google Patents

A kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof Download PDF

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Publication number
CN106176345A
CN106176345A CN201610555531.6A CN201610555531A CN106176345A CN 106176345 A CN106176345 A CN 106176345A CN 201610555531 A CN201610555531 A CN 201610555531A CN 106176345 A CN106176345 A CN 106176345A
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cosmetics
antioxidant peptides
collagen
vitamin
skin
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杨安树
陈红兵
吴志华
李欣
佟平
袁娟丽
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Nanchang University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29Titanium; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • A61K8/375Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/591Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596

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  • Health & Medical Sciences (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Cosmetics (AREA)

Abstract

A kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof, its component include collagen antioxidant peptides, Fructus Cucumidis sativi extract, vitamin C, vitamin E, lecithin, glyceryl monostearate, Semen Tritici aestivi germ oil, germall BP, glycerol, hyaluronic acid, nano titanium oxide, jasmin quintessence oil, pigment, remaining be deionized water.The anti-oxidation peptide that the present invention obtains with collagen protein in enzymolysis fish scale, as main composition, prepares collagen antioxidant peptides looks improving and the skin nourishing cosmetics by suitable proportioning.Its preparation technology is simple, scientific formulation, it is not necessary to substantial amounts of equipment investment, low cost, large-scale production suitable for industrialized;Products obtained therefrom performance is gentle, the most comfortable, there is the effects such as antioxidation, uvioresistant, antibacterial, whitening skin and preserving moisture, removing interior free yl, slow down aging, these cosmetics can cover skin surface naturally, makes skin more smooth, fine and smooth, tender white and high resilience.

Description

A kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof
Technical field
The invention belongs to cosmetic technical field.
Background technology
Along with improving constantly that people's living standard and health cosmetic are realized, cosmetics have become as in our daily life Indispensable necessary, the consumption demand of cosmetics is either all existed by people in many-sides such as quantity, kind or quality Increasing rapidly, consumer starts to pursue more healthy, safely effectively cosmetics.Therefore, animals and plants functional additive is because of it Act on efficient and gentle, Cosmetic Market occupies increasingly consequence.
All the time, antioxidant undertakes in the cosmetics such as emulsion, beautifying liquid as formula and prevents cosmetics itself The effect aoxidized and the snperoxiaized effect preventing sebum on the skin be coated with cosmetics.Use in cosmetics at present is anti- Oxidant is mainly derived from chemosynthesis, bigger to harm.Therefore, people target diversion from edible animals and plants group Knit the inner extraction Natural antioxidant.But, Natural antioxidant content present in the natural material is relatively low, finds more extensively to come The antioxidant in source causes the common concern of Food Science man of various countries.The development of bioscience shows, uses various enzyme or micro- The hydrolyzate of biological hydrolysis animal-plant material albumen exists multiple anti-oxidation peptide, and its antioxidant activity and material protein Higher.
Fish scale contains rich in protein, accounts for the 50%-70% of fish scale gross mass, mainly collagen protein.Research finds fish In squama, collagen protein has the features such as molecular structure is more fragile, enzymolysis is easier to, containing biologically active peptide in its hydrolyzate.And Collagen peptide has characteristics such as molecular weight absorption low, easy, low-viscosity, and fish scale protein hydrolyzate has antioxidation, anti-ageing simultaneously Old and reduce blood pressure, reduce the effects such as blood total cholesterol.Therefore, collagen peptide has been widely used in medicine, food, day The field such as apply some make up.
Summary of the invention
It is an object of the invention to provide a kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof.
The present invention is achieved by the following technical solutions.
One of the present invention looks improving and the skin nourishing cosmetics Han collagen antioxidant peptides, its constituent is by weight ratio For: collagen antioxidant peptides 5.0-10.0%, Fructus Cucumidis sativi extract 4.0-8.0%, vitamin C 1.0-3.0%, vitamin E 0.5- 3.0%, lecithin 2.0-5.0%, glyceryl monostearate 1.0-2.5%, Semen Tritici aestivi germ oil 1.0-5.0%, germall BP 0.2- 1.0%, glycerol 1.0-4.0%, hyaluronic acid 0.4-2.0%, nano titanium oxide 0.5-2.0%, jasmin quintessence oil 0.2-0.5%, pigment 0. 1-0.5%, remaining for deionized water.
Described collagen antioxidant peptides, is through immobilization enzymolysis fish scale collagen gained, and molecular weight is 300- 1000 dalton.
The particle diameter of described nano titanium oxide is 30-100 nm.
A kind of preparation method containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics of the present invention, is characterized in that including Following steps:
(1) oil phase composition is prepared: add lecithin, vitamin E, Semen Tritici aestivi germ oil and monostearate by proportioning in a reservoir sweet Oils and fats, heats to 80-95 DEG C, and constantly stirs, and treats that each raw material all melts, is kept molten by.
(2) aqueous phase composition is prepared: in the container containing deionized water, add anti-oxidation peptide, glycerol, transparent by proportioning Matter acid, germall BP, be slowly stirred uniformly and be warmed up to 60-75 DEG C, treating that each raw material all dissolves.
(3) by after oil phase and the mixing of aqueous phase material, homogenizing, add nanometer titanium dioxide peptide, continue stirring, slowly cool down.
(4) when material is cooled to 40-50 DEG C, add Fructus Cucumidis sativi extract, jasmin quintessence oil, pigment, to be mixed, mixing after, Fill i.e. obtains described cosmetics.
A kind of fish scale collagen antioxidation active peptides cosmetics that the present invention provides and preparation method thereof, with scale collagen Protein antioxidant peptide is functional active components, then adds suitable whitening agent, emollient, wetting agent, emulsifying agent, preservative etc., Collagen antioxidant peptides cosmetics are prepared by suitable proportioning.These cosmetics preparation technology is simple, scientific formulation, suitable work Industry large-scale production;The cosmetic active ingredient invented is natural, safety and good stability, has defying age, antioxidation, U.S. The effects such as white moisturizing, are effective against dry environment simultaneously, recover the skin of elastic brilliance, and skin beauty water profit is tender.
The invention have the advantage that 1, cosmetics preparation technology disclosed by the invention is simple, scientific formulation, it is not necessary to substantial amounts of set Standby input, low cost, suitably in the large-scale production of industry;2, products obtained therefrom performance is gentle, the most comfortable, have antioxidation, The effect such as uvioresistant, antibacterial, radioprotective, whitening skin and preserving moisture, removing interior free yl, slow down aging, these cosmetics can be natural Ground covers skin surface, makes skin more smooth, fine and smooth, tender white and high resilience.
Detailed description of the invention
The present invention will be described further by example in detail below.
Embodiment 1.
1. the looks improving and the skin nourishing cosmetic formulations Han collagen antioxidant peptides.
Collagen antioxidant peptides 5.0%, Fructus Cucumidis sativi extract 4.0%, vitamin C 1.0%, vitamin E 0.5%, lecithin 2.0%, glyceryl monostearate 1.0%, Semen Tritici aestivi germ oil 1.0%, germall BP 0.2%, glycerol 1.0%, hyaluronic acid 0.4%, nanometer Titanium dioxide 0.5%, jasmin quintessence oil 0.2%, pigment 0. 1%, remaining be deionized water.
Described collagen antioxidant peptides, this peptide is that molecular weight is through immobilization enzymolysis fish scale collagen gained 300 dalton.
The particle diameter of described nano titanium oxide is 100 nm.
2. the processing method containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics.
1) oil phase composition is prepared: add lecithin, vitamin E, Semen Tritici aestivi germ oil and single tristearin by proportioning in a reservoir Acid glyceride, heats to 80 DEG C, and constantly stirs, and treats that each raw material all melts, is kept molten by.
2) aqueous phase composition is prepared: in the container containing deionized water, add anti-oxidation peptide, glycerol, hyalomitome by proportioning Acid, germall BP, be slowly stirred uniformly and be warmed up to 60 DEG C, treating that each raw material all dissolves.
3) by after oil phase and the mixing of aqueous phase material, homogenizing, add nanometer titanium dioxide peptide, continue stirring, slowly cool down.
4) when material is cooled to 40 DEG C, add Fructus Cucumidis sativi extract, jasmin quintessence oil, pigment, to be mixed, mixing after, fill Obtain described cosmetics.
Embodiment 2.
1. the looks improving and the skin nourishing cosmetic formulations Han collagen antioxidant peptides.
Collagen antioxidant peptides 8.0%, Fructus Cucumidis sativi extract 6.0%, vitamin C 2.0%, vitamin E 2.0%, lecithin 3.0%, glyceryl monostearate 1.5%, Semen Tritici aestivi germ oil 3.0%, germall BP 0.8%, glycerol 3.0%, hyaluronic acid 1.0%, nanometer Titanium dioxide 1.5%, jasmin quintessence oil 0.4%, pigment 0. 3%, remaining be deionized water.
Described collagen antioxidant peptides, this peptide is that molecular weight is through immobilization enzymolysis fish scale collagen gained 500 dalton.
The particle diameter of described nano titanium oxide is 60 nm.
2. the processing method containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics.
1) oil phase composition is prepared: add lecithin, vitamin E, Semen Tritici aestivi germ oil and single tristearin by proportioning in a reservoir Acid glyceride, heats to 85 DEG C, and constantly stirs, and treats that each raw material all melts, is kept molten by.
2) aqueous phase composition is prepared: in the container containing deionized water, add anti-oxidation peptide, glycerol, hyalomitome by proportioning Acid, germall BP, be slowly stirred uniformly and be warmed up to 70 DEG C, treating that each raw material all dissolves.
3) by after oil phase and the mixing of aqueous phase material, homogenizing, add nanometer titanium dioxide peptide, continue stirring, slowly cool down.
4) when material is cooled to 45 DEG C, add Fructus Cucumidis sativi extract, jasmin quintessence oil, pigment, to be mixed, mixing after, fill Obtain described cosmetics.
Embodiment 3.
1. the looks improving and the skin nourishing cosmetic formulations Han collagen antioxidant peptides.
Collagen antioxidant peptides 10.0%, Fructus Cucumidis sativi extract 8.0%, vitamin C 3.0%, vitamin E 3.0%, lecithin 5.0%, glyceryl monostearate 2.5%, Semen Tritici aestivi germ oil 5.0%, germall BP 1.0%, glycerol 4.0%, hyaluronic acid 2.0%, nanometer Titanium dioxide 2.0%, jasmin quintessence oil 0.5%, pigment 0.5%, remaining be deionized water.
Described collagen antioxidant peptides, this peptide is that molecular weight is through immobilization enzymolysis fish scale collagen gained 1000 dalton.
The particle diameter of described nano titanium oxide is 30 nm.
2. the processing method containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics.
1) oil phase composition is prepared: add lecithin, vitamin E, Semen Tritici aestivi germ oil and single tristearin by proportioning in a reservoir Acid glyceride, heats to 95 DEG C, and constantly stirs, and treats that each raw material all melts, is kept molten by.
2) aqueous phase composition is prepared: in the container containing deionized water, add anti-oxidation peptide, glycerol, hyalomitome by proportioning Acid, germall BP, be slowly stirred uniformly and be warmed up to 75 DEG C, treating that each raw material all dissolves.
3) by after oil phase and the mixing of aqueous phase material, homogenizing, add nanometer titanium dioxide peptide, continue stirring, slowly cool down.
4) when material is cooled to 50 DEG C, add Fructus Cucumidis sativi extract, jasmin quintessence oil, pigment, to be mixed, mixing after, fill Obtain described cosmetics.

Claims (4)

1. looks improving and the skin nourishing cosmetics Han collagen antioxidant peptides, it is characterised in that by weight percentage, including following Component: collagen antioxidant peptides 5.0-10.0%, Fructus Cucumidis sativi extract 4.0-8.0%, vitamin C 1.0-3.0%, vitamin E 0.5-3.0%, lecithin 2.0-5.0%, glyceryl monostearate 1.0-2.5%, Semen Tritici aestivi germ oil 1.0-5.0%, germall BP 0.2- 1.0%, glycerol 1.0-4.0%, hyaluronic acid 0.4-2.0%, nano titanium oxide 0.5-2.0%, jasmin quintessence oil 0.2-0.5%, pigment 0. 1-0.5%, remaining for deionized water.
Cosmetics the most according to claim 1, it is characterised in that described collagen antioxidant peptides, are through fixing Changing enzymolysis fish scale collagen gained, molecular weight is 300-1000 dalton.
Cosmetics the most according to claim 1, it is characterised in that the particle diameter of described nano titanium oxide is 30-100 nm。
4. containing the preparation method of collagen antioxidant peptides looks improving and the skin nourishing cosmetics described in claim 1, it is characterized in that including as Lower step:
(1) oil phase composition is prepared: add lecithin, vitamin E, Semen Tritici aestivi germ oil and monostearate by proportioning in a reservoir sweet Oils and fats, heats to 80-95 DEG C, and constantly stirs, and treats that each raw material all melts, is kept molten by;
(2) prepare aqueous phase composition: in the container containing deionized water by proportioning add anti-oxidation peptide, glycerol, hyaluronic acid, Germall BP, is slowly stirred uniformly and is warmed up to 60-75 DEG C, treating that each raw material all dissolves;
(3) by after oil phase and the mixing of aqueous phase material, homogenizing, add nanometer titanium dioxide peptide, continue stirring, slowly cool down;
(4) when material is cooled to 40-50 DEG C, add Fructus Cucumidis sativi extract, jasmin quintessence oil, pigment, to be mixed, mixing after, fill Obtain described cosmetics.
CN201610555531.6A 2016-07-15 2016-07-15 A kind of containing collagen antioxidant peptides looks improving and the skin nourishing cosmetics and preparation method thereof Pending CN106176345A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107115558A (en) * 2017-04-27 2017-09-01 王天湶 A kind of wound dressing of anti-pigment deposition and preparation method thereof
CN107383167A (en) * 2017-08-07 2017-11-24 温州千瑞生物科技有限公司 Antioxidation active peptides and application thereof

Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2007217358A (en) * 2006-02-17 2007-08-30 Nippon Meat Packers Inc Anti-oxidizing peptide
CN102908304A (en) * 2012-11-19 2013-02-06 浙江省林业科学研究院 Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof
CN103705431A (en) * 2014-01-09 2014-04-09 山东省淡水渔业研究院 Fish source collagen antioxidant peptide beauty mask and preparation method thereof
CN104306277A (en) * 2014-09-20 2015-01-28 青岛点石文具用品有限公司 Cucumber toner and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007217358A (en) * 2006-02-17 2007-08-30 Nippon Meat Packers Inc Anti-oxidizing peptide
CN102908304A (en) * 2012-11-19 2013-02-06 浙江省林业科学研究院 Anti-ageing wrinkle reduction toning lotion enriched with active peptide, and preparation method thereof
CN103705431A (en) * 2014-01-09 2014-04-09 山东省淡水渔业研究院 Fish source collagen antioxidant peptide beauty mask and preparation method thereof
CN104306277A (en) * 2014-09-20 2015-01-28 青岛点石文具用品有限公司 Cucumber toner and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107115558A (en) * 2017-04-27 2017-09-01 王天湶 A kind of wound dressing of anti-pigment deposition and preparation method thereof
CN107383167A (en) * 2017-08-07 2017-11-24 温州千瑞生物科技有限公司 Antioxidation active peptides and application thereof

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Application publication date: 20161207