CN103520066A - Edible natural propolis antibacterial toothpaste and preparation method thereof - Google Patents
Edible natural propolis antibacterial toothpaste and preparation method thereof Download PDFInfo
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- CN103520066A CN103520066A CN201310319917.3A CN201310319917A CN103520066A CN 103520066 A CN103520066 A CN 103520066A CN 201310319917 A CN201310319917 A CN 201310319917A CN 103520066 A CN103520066 A CN 103520066A
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Abstract
The invention discloses edible natural propolis antibacterial toothpaste and a preparation method thereof. The edible natural propolis antibacterial toothpaste is prepared from the following raw materials in percentage by weight: 0.2-0.8 percent of propolis extract, 15-20 percent of abrasive, 50-70 percent of wetting agent, 0.5-1.0 percent of adhesive, 2.0-3.0 percent of foaming agent, 0.1-0.3 percent of sweetening agent, 0.5-3.5 percent of conditioning agent, 0.1-0.3 percent of preservative, 1.0-1.2 percent of essence and the balance of deionized water. By utilizing natural antibacterial and preservative properties of propolis, the toothpaste is non-toxic and nonirritant; the propolis instead of triclosan, formaldehyde, sodium benzoate and enhanceparaben is applied to the toothpaste, so that use of synthetic antimicrobials is reduced; the toothpaste has a good antibacterial effect, and the potential safety hazard can be avoided.
Description
Technical field
The present invention relates to daily necessities field, relate in particular to the antibacterial toothpaste of a kind of natural propolis.
Background technology
Ten hundreds of antibacterials, just as one " antibacterial cistern ", especially, under dental bed, is filled especially in oral cavity, and the number of bacteria in Human Oral Cavity is huge, of a great variety.Medical research report shows, the patient who suffers from periodontal disease, than normal person, more easily suffer from heart disease, the probability that the women who suffers from serious periodontal disease gives birth to premature infant or underweight baby is 7 times of general anemia of pregnant woman, and controlling oral cavity pathogen is the main task of prevention oral disease.
In recent years, natural drug is as a kind of alternative of health care, become a kind of Critical policies in new drug development, propolis is good medicine and the anticorrosion sealant of bee colony, he can be antibiotic anticorrosion, seal perishables up for safekeeping in order to avoid go bad, in " Chinese traditional Chinese medical science medical science medicine periodical " 03 phase in 2008 " experimentation of Antioxidation of Propolis ", drawing: suppressing in atherosclerotic lesion process, propolis has the conclusion of lipoid peroxidization resistant.So utilize propolis can replace toothpaste is generally used on the market triclosan, formaldehyde, sodium benzoate, Nipagin ester etc. as antibiotic, antiseptic.
In Chinese invention patent application number: 201110241483.0 disclose " a kind of bee glue tooth paste and preparation method thereof ", it is first propolis to be dissolved in to 95% ethanol as propolis alcoholic solution, again by saccharin sodium, ethylparaben sodium, soluble propylhydroxybenzoate is water-soluble, sorbitol mixes with Polyethylene Glycol, silicon dioxide, natural whiting, sodium lauryl sulphate and that zinc citrate mixes, triclosan is dissolved in essence is standby, then standby is put into Manufacturing medicine extract machine.This invention adds natural propolis in toothpaste, and by the daily control bacterial plaque of brushing teeth, bee glue tooth paste has nourishing and protection gingiva effect, prevents oral disease comprehensively.But this invention as on the market triclosan that toothpaste is generally used are as antibacterial, although triclosan has good bactericidal effect, but the safety about triclosan, there is in recent years larger dispute always, from its can muscle injury function to carcinogenecity etc., although do not have human carcinogen's research data, still cause that consumers in general pay close attention to and worry.In addition, the same formaldehyde for toothpaste, sodium benzoate, Nipagin ester etc. synthetic antibacterial agents, also all there is certain potential safety hazard, and 201110241483.0 disclosed " a kind of bee glue tooth pastes and preparation method thereof " its in process of production propolis is dissolved in to 95% ethanol and has destroyed the original edibility of propolis as propolis alcoholic solution, and people can have unavoidably a little to swallow when brushing teeth, how much also this some potential safety hazard.
Summary of the invention
The invention provides and a kind ofly with natural propolis, replace triclosan, formaldehyde, sodium benzoate, Nipagin ester etc. to be applied in toothpaste, reduce the use of synthetic antibacterial agents, eliminate the potential safety hazard of using synthetic antibacterial agents to exist.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is:
Antibacterial toothpaste of a kind of edibility natural propolis and preparation method thereof, is characterized in that: the weight proportion of raw material is propolis extract 0.2～0.8%, abrasivus 15～20%, wetting agent 50～70%, binding agent 0.5～1.0%, foaming agent sodium lauryl sulphate 2.0～3.0%, sweeting agent 0.1～0.3%, regulator 0.5～3.5%, antiseptic 0.1～0.3%, essence 1.0～1.2%, deionized water surplus.
Preparation process is as follows:
1) Powdered abrasivus, binding agent, foaming agent is pre-mixed to stand-by in powder material tank;
2) by sweeting agent, regulator, antiseptic, by formula, weigh up, in water, mixing and stirring is stand-by;
3) propolis extract is weighed up by formula, in high speed disperser, with Polyethylene Glycol, stir stand-by;
4) by wetting agent, by formula weigh up in liquid tank, mix stand-by;
5) open the vacuum system of Manufacturing medicine extract machine, vacuum is evacuated to-0.5mpa; Import step 2,3 and 4 material, start agitator simultaneously.After having entered step 2,3 and 4 material, vacuum is evacuated to-0.85mpa starts to import the material in step 1, and keeps vacuum between-0.6～-0.85mpa, until the material in step 1 has been entered;
6) in vacuum, under-0.92～0.98mpa, stir 40 minutes, add essence, then stir 15 minutes;
7) open the normal pressure valve of Manufacturing medicine extract machine, after the gas of Manufacturing medicine extract machine is all emitted, the mastic in Manufacturing medicine extract machine is pumped into and stores that pot is displayed, then packing.
Further, described abrasivus is that silicon dioxide, wetting agent are that one or more combinations, binding agent in sorbitol, glycerol, PEG-4000 is that one or more combinations in sodium carboxymethyl cellulose, xanthan gum, guar gum, described foaming agent are that sodium lauryl sulphate, described sweeting agent are that glucide, described regulator are one or more combinations in mineral salt, tetrasodium pyrophosphate, tertiary sodium phosphate, described antiseptic is benzoates.
From the above-mentioned description to structure of the present invention, compared to the prior art, tool of the present invention has the following advantages:
1. this toothpaste has reduced the use of triclosan, formaldehyde, sodium benzoate, Nipagin ester etc., reduced the potential safety hazard of using synthetic antibacterial agents to exist, and propolis etc. is insoluble to any chemical article in whole production process, neglectful swallowing when brushing teeth, can not cause any harm to human body, it has certain edibility.
2. the present invention has removed the use of antimicrobial triclosan in traditional toothpaste; by combinations such as 0.2～0.8% propolis extract and a certain amount of abrasivus, wetting agents; the unexpected effect obtaining is: than triclosan, as antibacterial, more can more fully protect the effect of gingiva; prevention oral disease; and have no side effect; use safety, do not produce drug resistance.
3. the present invention is applied to by natural propolis the non-oxidizability that toothpaste has improved toothpaste, makes its shelf-life elongated.
The specific embodiment
Below embodiments of the invention are described in further detail.
The first embodiment
Count by weight percentage, it is as follows that formula comprises composition:
Propolis extract: 0.6%
Essence: 1.0%
Abrasivus: silica 1 6%
Wetting agent: sorbitol 66%
Binding agent: sodium carboxymethyl cellulose 1.0%
Foaming agent: sodium lauryl sulphate 2.5%
Sweeting agent: glucide 0.2%
Regulator: mineral salt 2.5%
Antiseptic: benzoates 0.1%
Deionized water to 100%
The antibacterial toothpaste of natural propolis, preparation process is as follows:
1) Powdered silicon dioxide, sodium carboxymethyl cellulose, sodium lauryl sulphate is pre-mixed to stand-by in powder material tank;
2) by glucide, mineral salt, benzoates, by formula, weigh up, in water, mixing and stirring is stand-by;
3) propolis extract is weighed up by formula, in high speed disperser, with Polyethylene Glycol, stir stand-by;
4) by sorbitol, by formula weigh up in liquid tank, mix stand-by;
5) open the vacuum system of Manufacturing medicine extract machine, vacuum is evacuated to-0.5mpa; Import step 2,3 and 4 material, start agitator simultaneously.After having entered step 2,3 and 4 material, vacuum is evacuated to-0.85mpa starts to import the material in step 1, and keeps vacuum between-0.6～-0.85mpa, until the material in step 1 has been entered;
6) in vacuum, under-0.92～0.98mpa, stir 40 minutes, add essence, then stir 15 minutes;
7) open the normal pressure valve of Manufacturing medicine extract machine, after the gas of Manufacturing medicine extract machine is all emitted, the mastic in Manufacturing medicine extract machine is pumped into and stores that pot is displayed, then packing.
The second embodiment
Count by weight percentage, it is as follows that formula comprises composition:
Propolis extract: 0.4%
Essence: 1.0%
Abrasivus: silica 1 8%
Wetting agent: PEG-4000 4%
Wetting agent: sorbitol 50%
Wetting agent: glycerol 4%
Binding agent: sodium carboxymethyl cellulose 0.5%
Binding agent: xanthan gum 0.3%
Binding agent: guar gum 0.1%
Foaming agent: sodium lauryl sulphate 2.5%
Sweeting agent: glucide 0.2%
Regulator: mineral salt 2%
Regulator: tetrasodium pyrophosphate 0.8%
Antiseptic: benzoates 0.1%
Deionized water to 100%
The antibacterial toothpaste of natural propolis, preparation process is as follows:
1) Powdered silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, guar gum, sodium lauryl sulphate etc. are pre-mixed to stand-by in powder material tank;
2) by glucide, mineral salt, tetrasodium pyrophosphate, benzoates, by formula, weigh up, in water, mixing and stirring is stand-by;
3) propolis extract is weighed up by formula, in high speed disperser, with Polyethylene Glycol, stir stand-by;
4) by sorbitol, glycerol, PEG-4000, by formula weigh up in liquid tank, mix stand-by;
5) open the vacuum system of Manufacturing medicine extract machine, vacuum is evacuated to-0.5mpa; Import step 2,3 and 4 material, start agitator simultaneously.After having entered step 2,3 and 4 material, vacuum is evacuated to-0.85mpa starts to import the material in step 1, and keeps vacuum between-0.6～-0.85mpa, until the material in rapid 1 has been entered;
6) in vacuum, under-0.92～0.98mpa, stir 40 minutes, add essence, then stir 15 minutes;
7) open the normal pressure valve of Manufacturing medicine extract machine, after the gas of Manufacturing medicine extract machine is all emitted, the mastic in Manufacturing medicine extract machine is pumped into and stores that pot is displayed, then packing.
The 3rd embodiment
Count by weight percentage example, it is as follows that formula comprises composition:
Propolis extract: 0.8%
Essence: 1.0%
Abrasivus: silica 1 4%
Wetting agent: sorbitol 60%
Binding agent: sodium carboxymethyl cellulose 0.4%
Foaming agent: sodium lauryl sulphate 2.5%
Sweeting agent: glucide 0.2%
Regulator: mineral salt 2%
Antiseptic: benzoates 0.1%
Deionized water to 100%
Preparation method is with embodiment 1.
The 4th embodiment
Count by weight percentage example, it is as follows that formula comprises composition:
Propolis extract: 0.8%
Essence: 1.0%
Abrasivus: silicon dioxide 20%
Wetting agent: sorbitol 55%
Binding agent: sodium carboxymethyl cellulose 0.8%
Foaming agent: sodium lauryl sulphate 2.5%
Sweeting agent: glucide 0.2%
Regulator: mineral salt 3%
Antiseptic: benzoates 0.1%
Deionized water to 100%
Preparation method is with embodiment 1.
These are only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Effect explanation:
1, compound toothpaste of the present invention is detected by GB8372, result is qualified, and stability reaches places 30-45 days in the time of 45 ℃, and mastic does not return slightly, not separated, loss of gloss is not damp.
2, sensory test: blind test is brushed teeth 100 person-times, feels slightly puckery 5 person-times, 3 person-times of sensation bitterness, and all the other mouthfeels are and can accept.
3, pre-bacterium test: get 60 experimenters by registration successively sequence, by table of random number method, experimenter is equally divided into three groups at random: experimental group 1 and matched group 2 and matched group 3, experimental group 1 adopts the antibacterial toothpaste of a kind of edibility natural propolis of the present invention, matched group 2 adopts market to add triclosan, the toothpaste of formaldehyde, sodium benzoate, Nipagin ester etc. synthetic antibacterial agents, experimental group 3 employings are not added propolis and are not added the toothpaste of synthetic antibacterial agents yet, and whole experimenters are carried out to method for brushing teeth guidance.Experimenter uses unified toothbrush, infected by antibacterial not obvious through 100 days experiment test experimental grouies 1 and all experimenters of matched group 2, and all experimenters of matched group 3 are infected obviously by antibacterial.
Experiment shows: do not add synthetic antibacterial agents and the toothpaste that adds natural propolis has good stability and biocidal property equally, and good mouthfeel is applicable to most of crowds.
Claims (8)
1. the antibacterial toothpaste of edibility natural propolis, is characterized in that: the weight proportion of raw material is: propolis extract 0.2～0.8%, abrasivus 15～20%, wetting agent 50～70%, binding agent 0.5～1.0%, foaming agent 2.0～3.0%, sweeting agent 0.1～0.3%, regulator 0.5～3.5%, antiseptic 0.1～0.3%, essence 1.0～1.2%, deionized water surplus.
2. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described abrasivus is silicon dioxide.
3. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described wetting agent is one or more combinations in sorbitol, glycerol, PEG-4000.
4. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described binding agent is one or more combinations in sodium carboxymethyl cellulose, xanthan gum, guar gum.
5. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described foaming agent is sodium lauryl sulphate.
6. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described sweeting agent is glucide, and regulator is one or more combinations in mineral salt, tetrasodium pyrophosphate, tertiary sodium phosphate.
7. the antibacterial toothpaste of a kind of edibility natural propolis according to claim 1, is characterized in that: described antiseptic is benzoates.
8. the preparation method of the antibacterial toothpaste of a kind of edibility natural propolis described in claim 1, is characterized in that carrying out according to the following steps:
1) Powdered abrasivus, binding agent, foaming agent is pre-mixed to stand-by in powder material tank;
2) by sweeting agent, regulator, antiseptic, by formula, weigh up, in water, mixing and stirring is stand-by;
3) propolis extract is weighed up by formula, in high speed disperser, with Polyethylene Glycol, stir stand-by;
4) by wetting agent, by formula weigh up in liquid tank, mix stand-by;
5) open the vacuum system of Manufacturing medicine extract machine, vacuum is evacuated to-0.5mpa; Import step 2,3 and 4 material, start agitator simultaneously, after having entered step 2,3 and 4 material, vacuum is evacuated to-0.85mpa starts to import the material in step 1, and keeps vacuum between-0.6～-0.85mpa, until the material in step 1 has been entered;
6) in vacuum, under-0.92～0.98mpa, stir 40 minutes, add essence, then stir 15 minutes;
7) open the normal pressure valve of Manufacturing medicine extract machine, after the gas of Manufacturing medicine extract machine is all emitted, the mastic in Manufacturing medicine extract machine pump into store pot go out display, then packing.
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| CN104287992A (en) * | 2014-09-26 | 2015-01-21 | 福建爱洁丽日化有限公司 | Tooth powder for whitening, removing stains and preventing tooth decay |
| CN105078782A (en) * | 2015-08-18 | 2015-11-25 | 福建爱洁丽日化有限公司 | Edible weakly-alkaline calcium supplement toothpaste free of saccharin sodium and fluorine for children and preparation method of toothpaste |
| CN106511194A (en) * | 2016-11-09 | 2017-03-22 | 江西诚志日化有限公司 | Bacteriostatic toothpaste containing bamboo juice and preparation method thereof |
| CN106580723A (en) * | 2017-02-21 | 2017-04-26 | 糖友管家（北京）健康管理有限公司 | Toothpaste and preparation method thereof |
| CN110167516A (en) * | 2017-01-31 | 2019-08-23 | 金伯利-克拉克环球有限公司 | Antibacterial compositions comprising benzoic ether and the method for inhibiting bacterial growth using the composition |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| CN111870545A (en) * | 2020-07-08 | 2020-11-03 | 广东人为峰健康管理有限公司 | Bee venom inflammation-clearing gel toothpaste and preparation method thereof |
| CN113476375A (en) * | 2021-08-13 | 2021-10-08 | 陈日和 | Bee venom toothpaste and preparation method thereof |
| CN115518023A (en) * | 2022-10-12 | 2022-12-27 | 西藏自治区农牧科学院农业研究所 | Propolis toothpaste |
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| CN100398091C (en) * | 2005-05-20 | 2008-07-02 | 远景生物科技（上海）有限公司 | An anti-cavity toothpaste with natural substances for children and method for making same |
| CN1899261B (en) * | 2006-07-26 | 2010-05-12 | 广州立白企业集团有限公司 | Baking soda toothpaste with salty taste |
| CN101829030B (en) * | 2010-05-07 | 2011-09-28 | 天津蓝天集团股份有限公司 | Cleupin-containing toothpaste |
| CN102342905A (en) * | 2011-10-24 | 2012-02-08 | 上海浩美净水设备有限公司 | Toothpaste |
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| CN104287992A (en) * | 2014-09-26 | 2015-01-21 | 福建爱洁丽日化有限公司 | Tooth powder for whitening, removing stains and preventing tooth decay |
| CN105078782A (en) * | 2015-08-18 | 2015-11-25 | 福建爱洁丽日化有限公司 | Edible weakly-alkaline calcium supplement toothpaste free of saccharin sodium and fluorine for children and preparation method of toothpaste |
| CN106511194A (en) * | 2016-11-09 | 2017-03-22 | 江西诚志日化有限公司 | Bacteriostatic toothpaste containing bamboo juice and preparation method thereof |
| CN110167516A (en) * | 2017-01-31 | 2019-08-23 | 金伯利-克拉克环球有限公司 | Antibacterial compositions comprising benzoic ether and the method for inhibiting bacterial growth using the composition |
| GB2573933A (en) * | 2017-01-31 | 2019-11-20 | Kimberly Clark Co | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
| US11252960B2 (en) | 2017-01-31 | 2022-02-22 | Kimberly-Clark Worldwide, Inc. | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same |
| CN110167516B (en) * | 2017-01-31 | 2022-08-30 | 金伯利-克拉克环球有限公司 | Antibacterial composition containing benzoate and method for inhibiting bacterial growth by using same |
| CN106580723A (en) * | 2017-02-21 | 2017-04-26 | 糖友管家（北京）健康管理有限公司 | Toothpaste and preparation method thereof |
| CN110859777A (en) * | 2019-12-27 | 2020-03-06 | 河北考力森生物科技有限公司 | Collagen toothpaste |
| CN111870545A (en) * | 2020-07-08 | 2020-11-03 | 广东人为峰健康管理有限公司 | Bee venom inflammation-clearing gel toothpaste and preparation method thereof |
| CN113476375A (en) * | 2021-08-13 | 2021-10-08 | 陈日和 | Bee venom toothpaste and preparation method thereof |
| CN115518023A (en) * | 2022-10-12 | 2022-12-27 | 西藏自治区农牧科学院农业研究所 | Propolis toothpaste |
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Inventor after: Chen Wanjin Inventor after: Chen Liangxiong Inventor after: Wang Bijing Inventor after: Wu Shijie Inventor before: Chen Wanjin Inventor before: Chen Liangxiong Inventor before: Wang Bijing Inventor before: Wu Shijie |
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Effective date of registration: 20190108 Address after: 363000 Second Floor of Technology Business Incubator in Liandong U Valley, Longwen District, Zhangzhou City, Fujian Province Patentee after: Nano a (Fujian) personal care products Co. Ltd. Address before: 363100 Roadside Village, Yancuo Town, Longhai City, Zhangzhou City, Fujian Province Patentee before: Fujian Azalli Daily Chemicals Co., Ltd. |
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