CN106963662A - One kind discoloration children's toothpaste and its preparation method and application - Google Patents
One kind discoloration children's toothpaste and its preparation method and application Download PDFInfo
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- CN106963662A CN106963662A CN201710153230.5A CN201710153230A CN106963662A CN 106963662 A CN106963662 A CN 106963662A CN 201710153230 A CN201710153230 A CN 201710153230A CN 106963662 A CN106963662 A CN 106963662A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention discloses one kind discoloration children's toothpaste and its preparation method and application.The toothpaste includes consisting of：Microcapsules, xylitol, FOS, hydrolyzed pearl solution, NMF, rubbing agent, surfactant, sodium salt containing pigment, the present invention discoloration children's toothpaste in capsule containing pigment can appropriateness friction dynamics and fraction time under, process of brushing teeth borehole blasting, so that foam color changes, brushed teeth to children and bring the visual effect of excitement, allow children to fall in love with to brush teeth, enjoy enjoyment of brushing teeth.The product of the present invention uses the application method of science, and being reused within the period of many days can help to provide help children's removal buccal smears, massage gum, reduce bacterial plaque, improve gingiva tissue resistance against diseases.
Description
Technical field
The present invention relates to oral care techniques field, more particularly to a kind of discoloration children's toothpaste and preparation method thereof and should
With.
Background technology
Chinese children mouth disease illness rate is higher, and wherein dental caries and periodontal disease are the most common mouth diseases of children.
Third National oral health epidemiological investigation result is shown within 2005, the dental caries of 5 years old deciduous teeth of China and 12 years old dental caries
Illness rate is up to 66% and 28.9% respectively.The factor for causing Pediatric Oral Emergency illness rate higher, except children tooth development, feed
The mode of supporting is improper outer, brushes teeth and equally plays an important role.
Children's decayed tooth illness rate is very high, but does not draw attention, and many treasured mothers think that the deciduous teeth of baby are to change sooner or later
, even if suffering from decayed tooth without excessively worrying.The incipient dental caries of deciduous teeth is bad or lacks, and the arrangement that can directly result in neonatal tooth is mixed
Disorderly, hinder attractive in appearance.Because the long-term oral cavity pain inflammation that decayed tooth is brought also brings pain to patient.
In summary, the toothpaste of suitable Pediatric Oral Emergency environment is selected, the correct method for brushing teeth of children is educated, culture children are just
True teeth brushing way, improves Pediatric Oral Emergency health very urgent.To the research in terms of Pediatric Oral Emergency environment compared with system comprehensively,
Each company of oral care industry is also proposed children's toothpaste, such as sound of baby talk pleasure, shellfish parent, objective dotey of relaxing successively.Culture children brush teeth
Interest, increase children brush teeth enjoyment, allow children to brush teeth by uninteresting task and become a kind of activity of entertaining, form and brush teeth 3 sooner or later
Minute is the effective way for solving Pediatric Oral Emergency present situation instantly.
In patent CN1077884A, a kind of liquid colour-changeable toothpaste and its production method are disclosed.The liquid colour-changeable toothpaste is used
Adsorbent replaces conventional friction agent, and added with materials such as elastin laminin and special additives, with comfortable taste, can deform and expand
Dissipate property good, to enamel without abrasion, layer protecting film can be formed with dental surface in oral cavity, and can direct indicating toothbrushing quality
The advantages of, it is a kind of preferable dental care product.
Chinese children oral cavity illness rate is higher, although developed under a large amount of Pediatric Oral Emergency environmental quality researchs with strong points
Children's toothpaste, but the children's toothpaste of the type can preferably improve the premise of Pediatric Oral Emergency environment or children are adhered to correct
Method for brushing teeth is brushed teeth three minutes sooner or later.Therefore develop a toothpaste and realize that allowing children to enjoy brushes teeth, falls in love with brush by certain approach
Tooth, will brush teeth is changed into a kind of entertaining activity and has very much realistic meaning.
The content of the invention
Present invention aims at a kind of discoloration children's toothpaste and its preparation method and application is provided, the colour-changeable toothpaste is in children
The capsule comprising pigment is with the addition of on the basis of formulation of tooth-paste.Children rub during brushing teeth in brush dynamics and lotion abrasive material
Lower capsule softening and explosion are wiped, the pigment of parcel gradually disperses, and is showed by foam color change.Setting brushes teeth 3
Minute capsule explosion, foam color, which change to brush teeth to children, brings the visual effect of excitement, helps children to remove buccal smears, press
Rub gum, reduce bacterial plaque, improve gingiva tissue resistance against diseases.
The invention provides one kind pigment containing parcel, the capsule of easy explosion under the friction dynamics and fraction time of appropriateness
Children's toothpaste.With the explosion of capsule during brushing teeth, foam color changes, and is brushed teeth to children and brings the vision effect of excitement
Really, allow children to fall in love with to brush teeth, enjoy enjoyment of brushing teeth.The product of the present invention uses the application method of science, in the period at many days
Interior reuse, which can help to provide, helps children's removal buccal smears, massage gum, reduction bacterial plaque, raising gingiva tissue disease-resistant
Ability.
According to the present invention there is provided a kind of children's colour-changeable toothpaste, discoloration is realized by capsule explosion of the addition containing pigment.This
Invention has advantages below：First, colour-changeable toothpaste involved in the present invention with the addition of the microcapsules of parcel pigment.Microcapsules be by
Food grade colorant is continuously dispersed in the capsule for the particulate that a matrix structure is constituted, and the capsule is formed using special technique
A kind of hydrogel matrix structure, water-insoluble powder, grease and water-soluble active thing can firmly be pinned.Second, the present invention
The microcapsules added are made up of components such as water, glycerine, sorbierite, pigment, carragheen, agar with certain proportioning, all components
It is the common raw material of toothpaste, microcapsules, which are added, compatibility and security well in toothpaste.3rd, it is micro- that children's toothpaste is added
Capsule, imparts the unique advantage of formulation of tooth-paste, enriches product form.4th, microcapsules are according to children's brush dynamics and children
Abrasive material feature designed toughness used in toothpaste, it is ensured that capsule explosion when Most of children is brushed teeth 3 minutes, when foam discoloration display is brushed teeth
Between arrive.
The object of the invention is achieved through the following technical solutions.
One kind discoloration children's toothpaste, including consisting of：
Preferably 1~5 part, more preferably 2~3 parts of the consumption of the microcapsules containing pigment.
Preferably 0.1~5 part, more preferably 0.1~1 part of the consumption of the xylitol.
Preferably 0.1~2 part, more preferably 0.1~1 part of the consumption of the FOS.
Preferably 0.05~1 part, more preferably 0.1~0.5 part of the consumption of the hydrolyzed pearl solution.
The sodium salt be saccharin sodium, sodium benzoate, crystalline sodium pyrophosphate, preferably 0.01~1 part of saccharin sodium consumption, more preferably
0.1~0.5 part；Preferably 0.01~1 part, more preferably 0.1~0.5 part of sodium benzoate consumption；Crystalline sodium pyrophosphate consumption is preferred
0.01~2 part, more preferably 0.3~0.8 part；
Also including antiseptic, ascoxal, antitack agent in children's colour-changeable toothpaste of the present invention, (prevention bacterial plaque sticks to tooth
Enamel surfaces), polyphenoils (such as Co-Q10), caries preventive agent, desensitizer (such as potassium nitrate, potassium tartrate, potassium citrate and chlorination
Strontium), brightening agent, tartar control agents, periodontal actives, chlorophyll compound, abrasive material, breath freshening controlling agent (such as zinc salt, for example
Zinc gluconate, zinc citrate, zinc chloride) and saliva stimulant (such as citric acid, lactic acid, malic acid), and this area skill
The composition that any other is applied to oral care known to art personnel.
Children's colour-changeable toothpaste of the present invention optionally includes other materials, such as viscosity modifier, diluent, surface-active substance
Matter, emulsifying agent and foam modifier, pH adjusting agent, abrasive material, NMF, softening agent, mouth feel modifying agents, sweetener, flavor enhancement
Toner, preservative and combinations thereof.Although the general aspects of each class of above-mentioned substance classification can be different, but it is also possible to have one
A little common properties, and two classes that can belong in these material classifications of any given material or more class.Preferably, according to this hair
The compatible material of bright described xylitol, FOS, hydrolyzed pearl solution.
On the other hand, the invention provides a kind of preparation method for the children's toothpaste that changes colour, comprise the following steps：
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is 42
Quick stirring 20min~30min under the conditions of DEG C；
(5) add laruyl alcohol sodium sulfovinate, essence, vacuum degree control more than -0.94Mpa quickly stirring 15min~
20min, microcapsules of the addition containing pigment of uncapping, under vacuum, scraper velocity control 30r/min~50r/min stir 8min~
10min；Pumping, it is filling.
The pumping is that vacuum degree control is persistently vacuumized 15 minutes in more than -0.96Mpa.
The toothpaste prepared by above-mentioned technique, at a temperature of 40 DEG C after accelerated ageing 3 months, microcapsules have been preserved in lotion
It is good, do not occur explosion, discoloration etc. is abnormal, and lotion is stable.
In the preparation method of the present invention, difficult point be how to prevent the microcapsules containing pigment cream process processed occur rupture with
Negative effect of the strong mixing power to particle toughness, the inventors found that by the microcapsules containing pigment after cream process processed
Phase adds, using low speed scraper plate stirring technique：Scraper plate mixing speed is controlled in 30r/min~50r/min；Mixing time control exists
8min~10min, can avoid destruction, the tough sexual abnormality generation of reduction microcapsules because of homogeneous strong mixing to microcapsule structure, it is ensured that
Microcapsules toothpaste storage period containing pigment does not rupture, and is ruptured again after brushing time reaches 3min, realizes expected effect.
The composition of the microcapsules containing pigment is as follows：In terms of parts by weight,
Described microcapsules of children's colour-changeable toothpaste addition containing pigment.The addition of carragheen and agar in microcapsules is provided
Hydrogel matrix structure, glycerine and sorbierite do anti-corrosive fresh-keeping composition.Microcapsules ingredient has good compatibility and safety
Property.Microcapsules are a series of particulates (about 0.8 millimeter) for including the continuous pigment being dispersed in a matrix structure
Capsule.Microcapsules form a kind of hydrogel matrix structure, can firmly catch water-insoluble powder, grease and water-soluble active
Thing.Pigment contained by microcapsules is food grade colorant (such as light blue pigment, lemon yellow pigment), and being discharged into colourless lotion to make
Eye-catching color change occurs for lotion.
Microcapsules of the present invention containing pigment are prepared using following steps：
(1) liquid phase is prepared：Pigment is added to the water and stirred, glycerine, sorbierite is added and stirs into uniformly into liquid phase；
(2) powder is prepared：Carragheen, agar, butylation polyvinylpyrrolidone are stirred, it is standby；
(3) powder is added into liquid phase, stirred, is spray-dried, the microcapsules containing pigment are made.
The microcapsules containing pigment are using being kept in dark place, and suitable storage temperature is 0~30 DEG C, under the storage condition
Microcapsules effective shelf-life is 12 months.
On the other hand, the application the invention provides a kind of described discoloration children's toothpaste in cleaning oral cavity, its feature
It is, application method is as follows：When children brush teeth, the toothpaste of soya bean size is squeezed on toothbrush, starting to brush teeth, it is found that lotion foam becomes
During color, represent that brushing time is arrived, oral cavity has been cleaned totally.Children are sooner or later when brushing teeth, and squeeze the toothpaste of soya bean size on toothbrush,
Brushed teeth by correct teeth brushing way, when finding the discoloration of lotion foam, represent that brushing time (about 3min) is arrived, oral cavity has been cleaned
It is clean.
Described children's colour-changeable toothpaste, formula design is carried out according to Pediatric Oral Emergency feature.For children it is higher suffer from dental caries,
Emphasis adds xylitol preventing decayed tooth.Xylitol preventing decayed tooth mechanism has following approach：It will not be utilized by the cariogenic cell fermentation in oral cavity, energy
Effectively suppress streptococcic growth and the generation of acid；Oral cavity can be stimulated to salivate, saliva can rinse the bacterium in oral cavity, increased
Saliva and basic amino acid and ammonia density at carious tooth spot, slow down the decline of oral pH, it is suppressed that bacterium is in dental surface
Absorption, slows down tooth erosion, prevents the generation of carious tooth and reduces the generation of bacterial plaque, healthy tooth.
Described children's colour-changeable toothpaste, with the addition of FOS and several amino acids compound (hydrolyzed pearl solution), nutrition
Gum, and help to reduce microbial growth, maintain Oral health behaviours balance.FOS is low polymerization degree multifunctional C aquation
Compound, is to generally acknowledge typical prebiotics, is also a kind of water-soluble dietary fiber, can promote the absorption of the mineral matters such as calcium, magnesium, zinc.
Hydrolyzed pearl solution is the active ingredient amino acid and multiple nutritional components extracted from pearl, rich in protein, with good
Nutrition and health care are acted on.
The present invention has the advantage that and beneficial effect relative to prior art.
(1) a kind of children's colour-changeable toothpaste of the invention, adds the microcapsules containing pigment, using unique microcapsules constituent
And unique preparation technology, when children brush teeth, under brushing pressure and abrasive material friction, rupture time can be controlled in 3min or so,
Capsule explosion foam changes colour, and forms the signal prompt that unique brushing time is arrived, foam color, which changes to brush teeth to children, brings emerging
The visual effect put forth energy, allows children to fall in love with and brushes teeth.
(2) by adding children's colour-changeable toothpaste of xylitol, FOS, hydrolyzed pearl solution isoreactivity thing in toothpaste,
With effective preventing decayed tooth, nutrition gum, reduce oral microorganism grow function, can effectively help children remove buccal smears,
Gum, the generation of pre- anti-caries are massaged simultaneously, reduced bacterial plaque, are improved gingiva tissue resistance against diseases.
Children's colour-changeable toothpaste of present invention addition capsule containing pigment, the color change of foam can be carried to children during brushing teeth
For unique sensory experience, it is a kind of eye-catching color signal prompting, is brushed teeth to children and bring enjoyment, appointed brushing teeth by dull
Business becomes interesting activity, allows children to fall in love with and brushes teeth, and adheres to brushing teeth sooner or later, helps children to remove buccal smears, massage gum, suppression
Gum bacteria breed processed, the strong gum of nutrition, raising gingiva tissue resistance against diseases, give children one healthy oral environment.
Embodiment
By embodiment, the present invention is described further.
The composition of microcapsules is as follows in the embodiment of the present invention：
The composition of the microcapsules containing pigment is as follows：In terms of parts by weight,
Preparation method is：
(1) liquid phase is prepared：Pigment is added to the water and stirred, glycerine, sorbierite is added and stirs into uniformly into liquid phase；
(2) powder is prepared：Carragheen, agar, butylation polyvinylpyrrolidone are stirred, it is standby；
(3) powder is added into liquid phase, stirred, is spray-dried, the microcapsules containing pigment are made.
Embodiment one：Weigh and stirred in 10g xylitols, 2.5g FOSs, 0.01g hydrolyzed pearl solutions addition aqueous phase
It is standby；Weigh 0.1g microcapsules room temperature preservations.
Embodiment two：Weigh in 0.01g xylitols, 0.01g FOSs, 2.5g hydrolyzed pearl solutions addition aqueous phase and stir equal
It is even standby；Weigh 10g microcapsules room temperature preservations.
Embodiment three：Weigh 5g xylitols, 5g FOSs, 5g hydrolyzed pearl solutions add aqueous phase in stir it is standby；
Weigh 5g microcapsules room temperature preservations.
The preparation embodiment of children's colour-changeable toothpaste：
Embodiment one：
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is 42
Quick stirring 20min~30min under the conditions of DEG C；
(5) add laruyl alcohol sodium sulfovinate, essence, vacuum degree control more than -0.94Mpa quickly stirring 15min~
20min, microcapsules of the addition containing pigment of uncapping, under vacuum, scraper velocity control 30r/min~50r/min stir 8min~
10min；Vacuum degree control is persistently vacuumized 15 minutes in more than -0.96Mpa, filling.
Embodiment two：
Formula is as follows：
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is 42
Quick stirring 20min~30min under the conditions of DEG C；
(5) add laruyl alcohol sodium sulfovinate, essence, vacuum degree control more than -0.94Mpa quickly stirring 15min~
20min, microcapsules of the addition containing pigment of uncapping, under vacuum, scraper velocity control 30r/min~50r/min stir 8min~
10min；Vacuum degree control is persistently vacuumized 15 minutes in more than -0.96Mpa, filling.
Embodiment three：
| Composition | Final content (%) |
| Microcapsules | 5 |
| Xylitol | 5 |
| FOS | 5 |
| Hydrolyzed pearl solution | 5 |
| Sorbierite | 45 |
| Glycerine | 3 |
| Saccharin sodium | 0.22 |
| Sodium benzoate | 0.25 |
| Crystalline sodium pyrophosphate | 0.3 |
| Essence | 0.8 |
| Sodium carboxymethylcellulose | 0.8 |
| Silica | 18 |
| Laruyl alcohol sodium sulfovinate | 1.8 |
| Water | Added to 100 |
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is 42
Quick stirring 20min~30min under the conditions of DEG C；
(5) add laruyl alcohol sodium sulfovinate, essence, vacuum degree control more than -0.94Mpa quickly stirring 15min~
20min, microcapsules of the addition containing pigment of uncapping, under vacuum, scraper velocity control 30r/min~50r/min stir 8min~
10min；Vacuum degree control is persistently vacuumized 15 minutes in more than -0.96Mpa, filling.
Reference examples one
Using the formula of embodiment one.Prepare toothpaste step as follows：
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is 42
Quick stirring 20min~30min under the conditions of DEG C；
(5) laruyl alcohol sodium sulfovinate, essence, the microcapsules containing pigment are added, vacuum degree control is fast in more than -0.94Mpa
Speed stirring 15min~20min, vacuum degree control is persistently vacuumized 15 minutes in more than -0.96Mpa, filling.
Experimental result：
It is as shown in the table that 1. the product stability of embodiment one investigates experiment：
It is intact using microcapsules in the lotion of preparation method embodiment one of the present invention in terms of the period of supervision of 3 months, not
There is explosion, discoloration etc. is abnormal, and lotion is stable.
It is as shown in the table that 2. the product stability of embodiment two investigates experiment：
It is intact using microcapsules in the lotion of preparation method embodiment two of the present invention in terms of the period of supervision of 3 months, not
There is explosion, discoloration etc. is abnormal, and lotion is stable.
It is as shown in the table that 3. the product stability of embodiment three investigates experiment：
It is intact using microcapsules in the lotion of preparation method embodiment three of the present invention in terms of the period of supervision of 3 months, not
There is explosion, discoloration etc. is abnormal, and lotion is stable.
It is as shown in the table that 4. the product stability of reference examples one investigates experiment：
In terms of the period of supervision of 3 months, there is explosion using microcapsules in lotion after strong stirring, cause lotion discoloration different
Often, lotion is unstable.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in embodiment disclosed and described above, to the present invention's
Some modifications and changes should also be as falling into the scope of the claims of the present invention.Although in addition, being used in this specification
Some specific terms, but these terms are merely for convenience of description, do not constitute any limitation to the present invention.
Claims (9)
1. one kind discoloration children's toothpaste, it is characterised in that including consisting of：
2. a kind of discoloration children's toothpaste according to claim 1, it is characterised in that the consumption of the microcapsules containing pigment
For 1~5 part.
3. a kind of discoloration children's toothpaste according to claim 1, it is characterised in that the consumption of the xylitol is 0.1~5
Part.
4. a kind of discoloration children's toothpaste according to claim 1, it is characterised in that the consumption of the FOS is 0.1
~2 parts.
5. a kind of discoloration children's toothpaste according to claim 1, it is characterised in that the consumption of the hydrolyzed pearl solution is
0.05~1 part.
6. a kind of discoloration children's toothpaste according to claim 1, it is characterised in that the sodium salt is saccharin sodium, benzoic acid
Sodium, crystalline sodium pyrophosphate.
7. the preparation method of a kind of discoloration children's toothpaste described in one of claim 1-6, it is characterised in that including following step
Suddenly：
(1) xylitol, hydrolyzed pearl solution, FOS and sodium salt are added to the water and are stirred into aqueous phase；
(2) sorbierite and glycerine are added into aqueous phase, stirs 5min~10min, obtain uniform liquid phase；
(3) silica, sodium carboxymethylcellulose are stirred into powder, it is standby；
(4) liquid phase, powder are added into Manufacturing medicine extract machine, vacuum degree control is more than -0.92Mpa, and water-bath temperature control is in 42 DEG C of bars
Quick stirring 20min~30min under part；
(5) laruyl alcohol sodium sulfovinate, essence are added, vacuum degree control quickly stirs 15min~20min in more than -0.94Mpa,
Uncap microcapsules of the addition containing pigment, under vacuum, scraper velocity control stir 8min~10min in 30r/min~50r/min；
Pumping, it is filling.
8. according to claim 7 preparation method, it is characterised in that the composition of the microcapsules containing pigment is as follows：With parts by weight
Number meter,
9. a kind of application of discoloration children's toothpaste in cleaning oral cavity described in one of claim 1-6, it is characterised in that children
When brushing teeth, the toothpaste of soya bean size is squeezed on toothbrush, starting to brush teeth, when finding the discoloration of lotion foam, represents that brushing time is arrived, mouth
Chamber has been cleaned totally.
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| CN110917065A (en) * | 2019-12-26 | 2020-03-27 | 苏州克劳丽化妆品有限公司 | Color-changing toothpaste containing biological enzyme coated particles and preparation method thereof |
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| CN113197794A (en) * | 2021-05-10 | 2021-08-03 | 广州市盛龙口腔清洁用品有限公司 | Children toothpaste for preventing decayed teeth and preparation method thereof |
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