CN106619193B - A kind of antibacterial whitening toothpaste and preparation method thereof - Google Patents
A kind of antibacterial whitening toothpaste and preparation method thereof Download PDFInfo
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- CN106619193B CN106619193B CN201710061243.XA CN201710061243A CN106619193B CN 106619193 B CN106619193 B CN 106619193B CN 201710061243 A CN201710061243 A CN 201710061243A CN 106619193 B CN106619193 B CN 106619193B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of antibacterial whitening toothpaste and preparation method thereof, belong to household chemicals field.Antibacterial whitening toothpaste prepared by the present invention contains 0.05 5% ε polylysines or ε polylysine hydrochlorides, 0.05 15% chitosan, 0.01 1% nisin, 0.01 1% dextranase and lotion of toothpaste matrix components.For the present invention using the effect that mutual Synergistic between natural antibacterial agent be present, the toothpaste produced is safe, and antibacterial activity is good, can effectively prevent and treat the generation of bacterial plaque and oral inflammation；And play and act synergistically with dextranase, intrinsic bacterial plaque is effectively removed, reaches total care oral cavity, keeps dental health, the effect of tooth-whitening.
Description
Technical field
The present invention relates to a kind of antibacterial whitening toothpaste and preparation method thereof, it is related to household chemicals field.
Background technology
It has been confirmed that, among carious tooth and chronic periodontitis (gum disease) both most common mouth diseases, dental plaque
Bacterium is main pathogenic factor.The prevention of both diseases of past focuses primarily upon the cleaning and maintenance of oral hygiene, including
Tartar is removed with toothbrush mechanical, or (is such as removed with other methods with wax wire or toothpick), later, people are tended to using fluorination
Thing, and fluoride has no effect to tartar bacterium, can only prevent tooth surface decalcification.Consider prevention the various of gum disease to arrange
Apply, machinery still takes advantage except tartar prevents the disease, and it is the most commonly used and most general to carry out oral cleaning with toothpaste and toothbrush
And method.
Chemical bactericide triclosan etc., also known as triclosan are with the addition of in most of tooth paste products in the market.
American researcher exists within 2012《State academy of sciences journal》On deliver report and claim, carried out for mouse and fish muscle cell
Test result indicates that triclosan disturbs the communication between two protein of an important ion channel, muscle is weakened
Strength.The researcher of the New York State University and Arizona State University is once to the urine of 184 pregnant woman in New York Brooker forest zone
Liquid and umbilical-cord blood-sample are chemically examined.They have found, all contain triclosan in all urine samples, contain trichlorine in the urine sample more than 85%
Block class.More it is a concern that more than triclosan is also contained in half umbilical-cord blood-sample, this shows that the chemical composition can be to tire
Youngster causes to directly affect.Food and drug administration will then issue a statement in the end of the year 2010, it is desirable to forbids containing triclosan and three
The antibacterial soap and shower cream of chlorine card class are sold in shop shelf.
To find a kind of natural, antibacterial material for having no toxic side effect for substituting triclosan, researchers have done many taste
Examination.Because the one-component antibacterial antiplaque agent spectrum having now been found that has his own strong points, can not play to the overall protected effect of tooth, because
This, one kind enhancing antibacterial effect, suppress daily preventing and treating of the broad spectrum antimicrobial agent for carious tooth of the formation of bacterial plaque have it is very big
Application value.
The content of the invention
For a series of above-mentioned deficiencies existing for prior art, the invention provides a kind of antibacterial whitening toothpaste, the tooth
Cream contains epsilon-polylysine or epsilon-polylysine hydrochloride, chitosan, nisin, dextranase and lotion of toothpaste base
Matter component.
In one embodiment of the invention, epsilon-polylysine or the epsilon-polylysine hydrochloride content is 0.05-
5%.
In one embodiment of the invention, the chitosan content is 0.05-15%.
In one embodiment of the invention, the streptococcus lactis cellulose content is 0.01-1%.
In one embodiment of the invention, the dextranase content is 0.01-1%.
In one embodiment of the invention, the lotion of toothpaste matrix components include abrasive, NMF, foaming
Agent, adhesive, sweetener, acid-base modifier, essence and deionized water.
In one embodiment of the invention, described abrasive is silica.
In one embodiment of the invention, described NMF is glycerine, sorbierite, in propane diols or polyethylene glycol
One kind or its combination.
In one embodiment of the invention, described adhesive is sodium cellulose glycolate, carragheen, guar gum,
One kind or its combination in xanthans.
In one embodiment of the invention, described foaming agent is lauryl sodium sulfate.
In one embodiment of the invention, described stabilizer is acid-base modifier, using citric acid, malic acid,
Sodium citrate, one or two kinds of combinations of natrium malicum.
In one embodiment of the invention, the sweetener is saccharin, trehalose, the one or more of Aspartame
Combination.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochloride are in the antibacterial whitening tooth
Mass percent in cream is 0.01-5%.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochloride are in the antibacterial whitening tooth
Mass percent in cream is 0.01-1%.
In one embodiment of the invention, epsilon-polylysine or epsilon-polylysine hydrochloride are in the antibacterial whitening tooth
Mass percent in cream is 0.01-0.5%.
In one embodiment of the invention, mass percent of the chitosan in the antibacterial whitening toothpaste is
0.05-15%.
In one embodiment of the invention, mass percent of the chitosan in the antibacterial whitening toothpaste is 0.2-
5%.
In one embodiment of the invention, mass percent of the chitosan in the antibacterial whitening toothpaste is 0.5-
5%.
In one embodiment of the invention, mass percent of the nisin in the antibacterial whitening toothpaste
For 0.01-1%.
In one embodiment of the invention, mass percent of the nisin in the antibacterial whitening toothpaste
For 0.02-0.2%.
In one embodiment of the invention, mass percent of the dextranase in the antibacterial whitening toothpaste is
0.01-1%.
In one embodiment of the invention, mass percent of the dextranase in the antibacterial whitening toothpaste is
0.06-0.4%.
Second object of the present invention is to provide the manufacture method of antibacterial whitening toothpaste, is to be prepared in the steps below：
Prepare antibacterial component：By mass fraction 0.05-5% epsilon-polylysines or epsilon-polylysine hydrochloride, 0.01-1% lactic acid chain
Coccus element, 0.05-15% chitosan are dissolved in 8~12g/L citric acid solutions, 45~55 DEG C of 1~4h of insulation, and stirring is equal
It is even；It is well mixed with adhesive, NMF, abrasive, foaming agent, essence, regulation pH is 6-7, adds mass fraction 0.01-
1% dextranase, grinding, degassing.
In one embodiment of the invention, methods described is specifically：
(1) antibacterial component is prepared：Epsilon-polylysine or epsilon-polylysine hydrochloride, nisin, chitosan are delayed
Slowly it is dissolved in 10g/L citric acid solutions, 50 DEG C of 1~2.5h of insulation, stirs；
(2) adhesive is added in NMF, is dispersed with stirring to form suspension；
(3) abrasive, foaming agent, essence, sweetener are added in purified water, is dispersed with stirring dissolving；
(4) solution of above-mentioned steps (3) is added in the solution of step (2), is uniformly mixing to obtain paste；
(5) solution of above-mentioned steps (1) is added in the paste of step (4), stirred；Use acid-base modifier
(sodium hydroxide) adjusts pH to 6-7.
(6) dextranase is added in pure water, added after dissolving into the paste of step (5).
(7) grind, degassing, vacuumize to obtain lotion of toothpaste.
The present invention also provides application of the antiseptic toothpaste in oral cleaning, periodontosis protection.
Beneficial effect：The toothpaste that the present invention is prepared using natural antibacterial agent is safe, has no toxic side effect, antibacterial activity
It is good, it can effectively suppress the breeding of the microorganisms such as the bacterium in oral cavity, fungi, the minimum to common are harmful microorganism in oral cavity
Mlc is less than 10ppm, and effectively prevents and treats the generation of bacterial plaque and oral inflammation；The toothpaste of the present invention passes through antiseptic and the right side
Intrinsic bacterial plaque can effectively be removed by revolving the synergy of sugared acid anhydride enzyme, according to CIE table colour standards, after the toothpaste using the present invention
Tooth L values be higher by control 12.5%, can reach antibacterial, whitening, permanent tooth total care oral cavity, keep the work of dental health
With.
Embodiment
The evaluation method that the present invention uses is as follows：
(1) minimal inhibitory concentration MIC evaluation methods
By the streptococcus mutans ATCC25135, actinobacillus actinomycetem comitans ATCC29523, gum porphin of oral cavity common pathogen
Quinoline monad ATCC33277, actinomyces viscosus ATCC19246, staphylococcus aureus are placed on broth bouillon and cultivate 24h,
Examination bacterium colony is supplied with oese picking representative configuration, is inoculated in 5mL LB fluid nutrient mediums, 37 DEG C, 200r/min, culture 2~
6h is to exponential phase.Appropriate bacterium solution is taken, bacteria concentration is adjusted to 10 with LB fluid nutrient mediums5CFU/mL.To minimal inhibitory concentration
MIC is measured.Under aseptic condition, step 1 component of each embodiment is pressed than dilution successively.By dilution factor from low to high successively
The 1st row of sterile 96 orifice plate are added to the 11st row, per the μ L of hole 50, the 12nd is classified as positive control, adds equivalent sterilized water.It is then every
Hole adds 50 μ L bacterium solutions, and sealing mixes.Now, the 1st hole to the 11st hole toothpaste end mass concentration be respectively 3200,1600,
800th, 400,200,100,50,25,12.5,6.25,3.125 μ g/mL (pressing lotion quality).With ELIASA determine 0h when
OD630nm values, then 96 orifice plates are placed in 37 DEG C of incubators and cultivate 24h, determine OD630nm values again.By contrast 0h with
The OD of bacterium solution during 24h630Nm values, MIC of the different embodiments to each main oral pathogenic bacteria is determined, fungistatic effect is weighed with this.
(2) plaque index
The present invention using the Dental Plaque index before and after each embodiment toothpaste to being counted.
144 adult men and women are divided into 6 groups, respectively brushed teeth once sooner or later daily using toothpaste, each toothpaste dosage is 2g.It is right
It is measured using subject's dental plaque index before toothpaste and after continuous use toothpaste 3 months, calculates and use front and rear tooth
Plaque index.As a result it is as shown in table 3.
Specific dental plaque index assay method is as follows：
Facing is dried up with air gun, direct visual perception is simultaneously observed by mouth mirror, and the side that probe pinpoint is used in combination is drawn
Facing is crossed, so that it is determined that the bacterial plaque amount near facing and gum edge.
Facings of the 0=at nearly gum edge is without bacterial plaque；
1=facings at nearly gum edge have thin bacterial plaque, but are invisible to the naked eye, and only streak facing just with the side of probe pinpoint
It can find；
2=has macroscopic moderate bacterial plaque in Yin Yuan areas or tooth proximal surface；
3=is in gingival sulcus and (or) Yin Yuan areas and neighbouring facing have a large amount of soft dirts.
Each tooth be divided into buccal surface it is near in, center, it is remote neutralize 4 areas of lingual surface, score respectively.The summation of 4 score values divided by 4 it is
For the score value of the tooth, the score value of each tooth is added divided by is the individual score value by inspection tooth number.The present invention shows liquid using with bacterial plaque
(basic fuchsin) carries out plaque stain, and method makes to be extruded with the cotton pellet containing plaque disclosing agent between each two phase adjacent teeth
Plaque disclosing agent diffuses to facing, is coated with the cheek of dental pattern, lingual surface, then is gargled with clear water, is then observed, colour attaching area is
Area be present in bacterial plaque.
As a result criterion is as follows：
0=is without bacterial plaque；
There is the mottled bacterial plaque being dispersed on facing at the nearly gum edge of 1=；
Bacterial plaque thin on facing is in continuously banding at the nearly gum edge of 2=；
3=bacterial plaque colored band is wider than 1mm, but the area of coverage is less than the 1/3 of facing；
4=bacterial plaques cover facing more than 1/3, but are no more than facing 2/3；
5=bacterial plaques cover facing more than 2/3.
(3) whitening effect is evaluated
Using the Isolated Tooth for having tooth stain, first manually saliva infiltrates under 37 DEG C, 100% relative humidity, then using 2g teeth
Cream, scrubbed using common soft bristle tooth brush, every time brush 1 minute, after rinsed well, dry with water, repeat abovementioned steps,
Scrub 30 times altogether.All teeth gather image in 2 weeks before scrub, after scrub by DIC respectively, and whole gatherer process enters in darkroom
OK.Machine system is debugged before operation every time, proofreaded 2 times with hawk, colored steel is proofreaded 1 time, to ensure shooting bar every time
The uniformity of part, then be placed in imaging center with standard color sample and calibrated, the state of machine is protected when gathering image every time with guarantee
Hold unanimously, colour code is removed after proof.In operating process, calibration should be repeated per hour to reduce error.By the digital picture of shooting
Input in computer, the L* of corona color, a*, b* values are determined using color analysis software GIANT, and calculate front and rear hair of brushing teeth
Luminosity (L* values).
Embodiment 1
Prepare raw material (by mass) according to following proportioning：Silica 25%, glycerine 10%, polyethylene glycol 3%, sorb
Alcohol 10%, sodium cellulose glycolate 1%, dodecyl sodium sulfate 2.0%, saccharin 0.2%, essence 1%, citric acid 1%, hydrogen-oxygen
Change sodium 0.5%, epsilon-polylysine 0.1%, chitosan 2%, nisin 0.05%, dextranase 0.1%, purified water
44.05%.
Toothpaste is prepared according to following steps,
(1) antibacterial component is prepared：0.1 part of epsilon-polylysine, 0.05 part of nisin, 2 parts of chitosans are slowly molten
For solution in acid-base modifier (1 part of citric acid be dissolved in prepared in 20 parts of purified waters acidolysis conditioning agent), 50 degree of insulations 2 are small
When, stir；
(2) 1 part of sodium cellulose glycolate is added to by 10 parts of glycerine, 3 parts of polyethylene glycol, what 10 parts of sorbierites were formed
In solution, it is dispersed with stirring to form suspension；
(3) 25 parts of silica, 2 parts of dodecyl sodium sulfates, 1 part of essence, 0.2 part of saccharin are added into 20 parts of purified waters
In, it is dispersed with stirring dissolving；
(4) solution of above-mentioned steps (3) is added in the solution of step (2), is uniformly mixing to obtain paste；
(5) solution of above-mentioned steps (1) is added in the paste of step (4), stirred；Use acid-base modifier
(0.5 part of sodium hydroxide) adjusts pH to 6-7.
(6) 0.1 part of dextranase is added in 4.05 parts of pure water, added after dissolving into the paste of step (5).
(7) grind, degassing, vacuumize to obtain lotion of toothpaste.
Reference examples 1
Embodiment is that step (1) is added without epsilon-polylysine or its hydrochloride with embodiment 1, difference, does not add
The epsilon-polylysine entered or its hydrochloride ratio are in step (1) by purified water polishing.
Reference examples 2
Embodiment is with embodiment 1, and difference is to be added without nisin in step (1), the breast not added
Acid streptococci element ratio is in step (1) by purified water polishing.
Reference examples 3
Embodiment is with embodiment 1, and difference is to be added without chitosan in step (1), the chitosan ratio not added
Example is in step (1) by purified water polishing.
Reference examples 4
Embodiment is with embodiment 1, and difference is to be added without dextranase in step (6), the dextrorotation not added
Sugared acid anhydride enzyme ratio is in step (6) by purified water polishing.
Reference examples 5
Embodiment is to be added without epsilon-polylysine or its hydrochloride in step (1) with embodiment 1, difference, newborn
Acid streptococci element, chitosan, adds 0.2 part of triclosan, the said components ratio not added is by purified water polishing.
The formulation of tooth-paste ratio (by mass) of table 1
Table 2 minimal inhibitory concentration MIC ※ (ppm) experimental result
The weight of bactericide is calculated with solid powder weight in ※ minimal inhibitory concentrations.
The result of table 2 clearly shows that, compared with reference examples 1-5, by natural component form containing nisin, ε-poly-
Lysine, the antibacterial whitening toothpaste of chitosan can significantly reduce minimal inhibitory concentration, with being used alone or using wherein 2 kinds of phases
Than, synergy can be played, for its bactericidal effect compared with commercially available conventional antimicrobial triclosan, effect is more excellent,
The dental plaque index of table 3
Note：Dental plaque index rate of descent=(referred to using 3 months bacterial plaques after preceding 3 months dental plaque indexs average value-use
Number average values) 3 months dental plaque indexs put down value ╳ 100% before/use
Found out by table 3, after the toothpaste 3 months of embodiment 1, dental plaque index has significantly to drop relative to reference examples
It is low.Confirm that embodiment toothpaste has more superior antibacterial effect compared to reference examples toothpaste.
The whitening effect of table 4 is evaluated
Found out by table 4, after the toothpaste 3 months of embodiment 1, tooth whitening effect evaluation number (luminosity) has phase
For significantly improving for reference examples.Confirm that embodiment toothpaste has more superior whitening effect compared to reference examples toothpaste.
The present invention is also to epsilon-polylysine or epsilon-polylysine hydrochloride, chitosan, nisin and dextran
Other contents of enzyme are attempted, and are as a result shown, as the concentration ＜ 0.01% of epsilon-polylysine or its hydrochloride, its antibacterial
Decreased effectiveness；When the concentration of epsilon-polylysine or its hydrochloride is in ＞ 3%, its antibacterial ability no longer strengthens, and to toothpaste
Mouthfeel can cause necessarily to influence；As chitosan ＜ 0.01%, antibacterial effect weakens；As chitosan content ＞ more than 5%, its
Compared with indissoluble solution, antibacterial ability no longer strengthens, moreover, such as viscosity can be caused big the physical behavior of toothpaste, it is uneven, easily stick
Deng negative effect；As nisin ＜ 0.01%, its antibacterial effect weakens；As nisin ＞ 1%, its compared with
Indissoluble solution, antibacterial ability no longer strengthen；When dextranase is in ＜ 0.06%, it, which decomposes bacterial plaque ability, to weaken；Work as the right side
Sugared acid anhydride enzyme is revolved in ＞ 1%, and it, which decomposes bacterial plaque ability, no longer strengthens.
Although the present invention is disclosed as above with preferred embodiment, it is not limited to the present invention, any to be familiar with this skill
The people of art, without departing from the spirit and scope of the present invention, it can all do various change and modification, therefore the protection model of the present invention
Enclose being defined of being defined by claims.
Claims (9)
1. a kind of antibacterial whitening toothpaste, it is characterised in that the toothpaste contains epsilon-polylysine or epsilon-polylysine hydrochloride, shell
Glycan, nisin, dextranase and lotion of toothpaste matrix；By mass, the epsilon-polylysine or ε-poly- bad ammonia
Acid hydrochloride content is 0.05-5%, chitosan content 0.05-15%, and streptococcus lactis cellulose content is 0.01-1%, dextrorotation
Sugared acid anhydride enzyme content is 0.01-1%.
2. antibacterial whitening toothpaste according to claim 1, it is characterised in that the lotion of toothpaste matrix includes abrasive,
NMF, foaming agent, adhesive, sweetener, acid-base modifier, at least one of essence and deionized water.
3. antibacterial whitening toothpaste according to claim 2, it is characterised in that described abrasive is silica.
4. the antibacterial whitening toothpaste according to Claims 2 or 3, it is characterised in that NMF is glycerine, sorbierite, the third two
Alcohol, one kind or its combination in polyethylene glycol.
5. antibacterial whitening toothpaste according to claim 4, it is characterised in that adhesive is sodium cellulose glycolate, OK a karaoke club
Glue, guar gum, one kind or its combination in xanthans.
6. according to claim 2-3,5 any described antibacterial whitening toothpastes, it is characterised in that sweetener is saccharin, trehalose,
One or more combinations in Aspartame.
7. prepare the method for the antibacterial whitening toothpaste described in claim 1, it is characterised in that prepared in the steps below：(1)
Prepare antibacterial component：To 0.05-5% epsilon-polylysines or epsilon-polylysine hydrochloride by mass, 0.01-1% lactic acid chain
Coccus element, 0.05-15% chitosan are dissolved in 8~12g/L citric acid solutions, 45~55 DEG C of 1~4h of insulation, and stirring is equal
It is even；(2) it is well mixed with adhesive, NMF, abrasive, foaming agent, essence, regulation pH is 6-7, is added by mass
0.01-1% dextranase, grinding, degassing.
8. according to the method for claim 7, it is characterised in that methods described is specifically：
(1) antibacterial component is prepared：Epsilon-polylysine or epsilon-polylysine hydrochloride, nisin, chitosan is slowly molten
Solution 50 DEG C of 1~2.5h of insulation, stirs in 10/L citric acid solutions；(2) adhesive is added in NMF, stirred
It is scattered to form suspension；(3) abrasive, foaming agent, essence, sweetener are added in purified water, is dispersed with stirring dissolving；(4) will
The solution of above-mentioned steps (3) is added in the solution of step (2), is uniformly mixing to obtain paste；(5) by the molten of above-mentioned steps (1)
Liquid is added in the paste of step (4), is stirred, adjust pH to 6-7；(6) dextranase is added in pure water, it is molten
Added after solution into the paste of step (5)；(7) grind, degassing, vacuumize to obtain lotion of toothpaste.
9. claim 1-3, application of the 5 any described antiseptic toothpastes in oral-cavity cleaning products are prepared.
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| CN107373668A (en) * | 2017-08-02 | 2017-11-24 | 苟春虎 | Lycium ruthenicum decayed tooth lozenge |
| CN108498401A (en) * | 2018-05-25 | 2018-09-07 | 钱兴 | A kind of preparation method of mouthwash |
| GB2578147A (en) * | 2018-10-18 | 2020-04-22 | Oraldent Ltd | Bioflavonoid compositions and their use |
| GB2578146A (en) | 2018-10-18 | 2020-04-22 | Citrox Biosciences Ltd | Bioflavonoid compositions and their use for water purification and food preservation |
| CN109820748B (en) * | 2019-03-25 | 2021-10-22 | 昆明蓝橙口腔医院有限责任公司 | Moisture-free matrix for oral products and application thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110946778A (en) * | 2019-12-19 | 2020-04-03 | 华熙生物科技股份有限公司 | Toothpaste with anti-inflammation and bacteriostasis functions |
| CN112089670A (en) * | 2020-09-29 | 2020-12-18 | 陕西恒远生物科技有限公司 | Children's anti-caries toothpaste containing natural antibacterial ingredients and preparation process thereof |
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| CN101502647B (en) * | 2008-02-04 | 2011-06-15 | 四川大学 | Medicament composition for preventing or/and treating decayed tooth and preparation method thereof |
| CN102000333B (en) * | 2010-11-26 | 2015-04-01 | 赵凯 | Immunoglobulin (IgY) antibody oral spray for preventing decayed teeth |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
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