CN105326656A - Oral antibacterial composition containing nisin and polylysine and preparation method thereof - Google Patents
Oral antibacterial composition containing nisin and polylysine and preparation method thereof Download PDFInfo
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- CN105326656A CN105326656A CN201510714037.5A CN201510714037A CN105326656A CN 105326656 A CN105326656 A CN 105326656A CN 201510714037 A CN201510714037 A CN 201510714037A CN 105326656 A CN105326656 A CN 105326656A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention provides an oral antibacterial composition containing nisin and polylysine. According to the composition, the growth of oral pathogenic bacteria such as porphyromonas gingivalis, actinobacillus actinomycetemcomitans, streptococcus mutans, lactic acid bacillus, staphylococcus aureus and candida albicans can be effectively inhibited, and tooth decay, gingivitis, periodontitis, ozostomia and the like can be prevented; the composition can be prepared into toothpaste, mouth wash, refreshing and tasting chips and chewing gum which are used for preventing and treating oral diseases. Meanwhile, the invention provides a preparation method of the compositions such as the toothpaste, the mouth wash, the refreshing and tasting chips and the chewing gum. The oral antibacterial composition prepared through the method can prevent and treat various oral diseases and has no toxic and side effect and allergy or stimulation phenomenon on a human body.
Description
Technical field
The present invention relates to a kind of oral cavity bacteriostatic composition containing nisin, polylysine, said composition is toothpaste, collutory, refreshing tablets, chewing gum, belongs to leisure food manufacture field.
Background technology
Along with improving constantly of people's living standard, oral hygiene obtains all the more the attention of people, the most general method is the anti-inflammation class toothpaste using some to contain the antibacterial such as triclosan, Tin monoxide, zinc citrate, but this kind of oral care product easily makes oral cavity bacterium produce drug resistance, and be added with chemical preservative, as sodium benzoate, potassium sorbate etc., the healthy existence of people is necessarily threatened.Therefore, people are badly in need of a kind of use safety, oral care product that bactericidal effect is good.Therefore biological Substance is selected more safely and effectively for people provide one.
Nisin, is also called nisin peptide, nisin, and the complete structure that Gross equals to illustrate for 1971 nisin molecule is made up of 34 aminoacid.Breast chain is to gram positive bacteria, and comprising pathogenic bacterias such as causing the Streptococcus mutans of dental caries and lactobacillus has stronger Growth and reproduction inhibitory action.Chen Xifu equals within 2011, to propose nisin and has certain effect to preventing dental caries.Meanwhile, Nisin easily degrade by some protease in human body alimentary canal, can not, at people's body accumulation, be universally acknowledged safe natural bacteriostatic agent.Poly-D-lysine is the biological species antibacterial in current natural bacteriostatic agent with excellent bacteriostasis property and huge business potential.Polylysine destroys bacterial cell structure, plays bacteriostasis.Polylysine antimicrobial spectrum is wide, for the bacillus in yeast, gram-bacteria even some phage etc. have and significantly suppress and killing action.Polylysine is to gram-positive micrococcus luteus, and Lactobacillus bulgaricus, hot streptococcus, gram-negative escherichia coli, Salmonella and saccharomycetic growth have obvious inhibition.
The invention provides a kind of oral cavity bacteriostatic composition containing nisin, polylysine and preparation method thereof, any chemical preservative is not used in said composition, and effectively can suppress the growth of the oral cavity pathogen such as porphyromonas gingivalis, actinobacillus actinomycetem comitans, Streptococcus mutans, lactobacillus, staphylococcus aureus, Candida albicans in gingiva, periodontal disease, dental caries production process, said composition can be used for preparing the products such as toothpaste, collutory, refreshing tablets, chewing gum, for people provide omnibearing oral care product.
Summary of the invention
The invention provides a kind of oral cavity bacteriostatic composition containing nisin, polylysine and preparation method thereof, said composition is toothpaste, collutory, refreshing tablets, chewing gum.
The present invention is realized by following technical scheme:
(1) toothpaste containing nisin, polylysine, nisin, polylysine are put into deionized water for stirring and dissolved, and mix with toothpaste matrix, send into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred grinds 30 minutes, vacuum outgas; Adding essence agitation grinding mixing in 15 minutes again, obtaining lotion of toothpaste, by packing after sterile filling.
(2) collutory containing nisin, polylysine, nisin, polylysine are put into deionized water for stirring and dissolved, and after mixing with collutory substrate, high-speed stirred is dissolved to all substances, by packing after sterile filling.
(3) refreshing tablets containing nisin, polylysine, after pulullan polysaccharide, xanthan gum, locust bean gum, carrageenan fully being mixed, is dissolved in it 5 by the hot water of 70 ~ 80 DEG C of volume; Add glycerol and flavoring agent again, stir 2 ~ 3 hours, obtained glue; Vacuum degassing is steeped, and obtain film forming liquid, the THICKNESS CONTROL of film is at 20 ~ 30 μm; Steam drying, baking temperature is 80 ~ 90 DEG C; Demoulding.
(4) chewing gum containing nisin, polylysine, mixed by the deionized water of above-mentioned glyceryl monostearate and 60 DEG C, abundant stirring and dissolving, obtains emulsion; The glycerol of above-mentioned mass fraction, xylitol, citric acid, Mentholum, Konjac glucomannan, acesulfame potassium, essence are added in the emulsion of insulation successively, obtains complex liquid; Joined while hot by complex liquid in the wheat gluten protein of above-mentioned mass fraction, obtain graininess dough after fully stirring evenly, room temperature is airtight leaves standstill 60 minutes, packs through rolling in flakes, after excision forming.
Beneficial effect of the present invention is:
(1) nisin in the present invention, the bactericidal effect of polylysine are good, and can kill multiple oral cavity pathogen, sterilizing rate is greater than 99.9%.
(2) nisin in the present invention is easily aminoacid by the Partial Protein enzymatic degradation of human body alimentary canal; Epsilon-polylysine is then decomposed into lysine in human body, and lysine is one of 8 seed amino acids of needed by human, can not put aside in vivo and cause untoward reaction.
(3) nisin in the present invention, epsilon-polylysine compositions are easy to make, to the substrate of toothpaste, collutory, refreshing tablets, chewing gum without particular/special requirement.
(4) in the present invention, nisin, polylysine have certain heat stability, are suitable for large-scale production.
Detailed description of the invention
Below in conjunction with instantiation, technical solution of the present invention and result of use thereof are further described, but, but institute of the present invention protection domain is not limited only to these examples.
Embodiment one
The deionized water for stirring joining 57.375% according to the ratio of nisin in toothpaste 0.075%, polylysine 0.05% is dissolved, mix with 16% Sorbitol, 14% hydrated silica, 9% glycerol, 2.2% sodium lauryl sulfate, 1.0% essence, 1.0% cellulose gum, 0.23% tetrasodium pyrophosphate, 0.22% saccharin sodium, send into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred grinds 30 minutes, vacuum outgas; Adding essence agitation grinding mixing in 15 minutes again, obtaining lotion of toothpaste, by packing after sterile filling.
Embodiment two
The deionized water for stirring adding 99.025% according to the ratio of nisin in collutory 0.075%, polylysine 0.05% is dissolved, after mixing with 0.3% sodium chloride, 0.1% calcium chloride, 0.3% potassium chloride, 0.15% sodium hydrogen phosphate, high-speed stirred is dissolved to all substances, by packing after sterile filling.
Embodiment three
Add in the deionized water of 76.685% 70 ~ 80 DEG C according to the ratio of nisin in refreshing tablets 0.075%, polylysine 0.05%, pulullan polysaccharide 18.0%, xanthan gum 0.04%, locust bean gum 0.06%, carrageenan 0.19%; Add 0.4% glycerol, the acesulfame potassium of total amount 1.5% and essence, 3% Mentholum again, stir 2 ~ 3 hours, obtained glue; Vacuum degassing is steeped, and obtains film forming liquid; Be coated with film forming liquid scraper type coating device with on corrosion resistant plate, the THICKNESS CONTROL of film is at 20 ~ 30 μm; Steam drying, baking temperature is 80 ~ 90 DEG C; Demoulding.
Embodiment four
According to the deionized water mixing of nisin in chewing gum 0.075%, polylysine 0.05%, glyceryl monostearate 1.2% and 60 DEG C, abundant stirring and dissolving, obtains emulsion; 5% glycerol, 1% xylitol, 0.8% citric acid, 0.3% Mentholum, 0.4% Konjac glucomannan, 0.4% acesulfame potassium, 0.05% essence are added in the emulsion of insulation successively, obtains complex liquid; Joined while hot by complex liquid in 65% wheat gluten protein, obtain graininess dough after fully stirring evenly, room temperature is airtight leaves standstill 60 minutes, packs through rolling in flakes, after excision forming.
Nisin, polylysine compositions in above-mentioned example 1-4 are tested as follows:
(1) Pharmaceutical Sciences, Shandong Province's bio-pharmaceutical institute adopts liquid dilution method and agar dilution, measures compositions in the present invention and has obvious inhibitory action to oral cavity pathogens such as porphyromonas gingivalis, actinobacillus actinomycetem comitans, Streptococcus mutans, lactobacillus, staphylococcus aureus, Candida albicans.
The compositions fungistatic effect (collarium diameter mm, x ± s, n=6) of table 1 embodiment 1-4
(2) Pharmaceutical Sciences, Shandong Province's peace comments central animals oral toxicity to test, and result shows LD
50be greater than 5000mg/kg, show that this compositions is nontoxic level product.
The composition oral Toxic test results of table 2 embodiment 1-4
Claims (10)
1. the oral cavity bacteriostatic composition containing nisin, polylysine, it is characterized in that said composition is is the forms such as toothpaste, collutory, refreshing tablets, chewing gum.
2. a preparation method for a kind of oral cavity bacteriostatic composition containing nisin, polylysine as claimed in claim 1, is characterized in that the substrate such as the nisin of the method different ratio, polylysine and toothpaste, collutory, refreshing tablets, chewing gum makes oral cavity bacteriostatic composition.
3. the preparation method of a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 2, is characterized in that wherein said toothpaste matrix is but is not limited to Sorbitol, hydrated silica, water, glycerol, sodium lauryl sulfate, essence, cellulose gum, tetrasodium pyrophosphate, saccharin sodium.
4. the preparation method of a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 2, is characterized in that wherein said collutory substrate is but is not limited to sodium chloride, calcium chloride, potassium chloride, sodium hydrogen phosphate, water.
5. the preparation method of a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 2, is characterized in that wherein said refreshing tablets substrate is but is not limited to pulullan polysaccharide, xanthan gum, locust bean gum, carrageenan, glycerol, acesulfame potassium, essence, Mentholum, water.
6. the preparation method of a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 2, is characterized in that wherein said chewing gum base is but is not limited to wheat gluten protein, glycerol, xylitol, glyceryl monostearate, citric acid, Mentholum, Konjac glucomannan, acesulfame potassium, aspartame, essence, water.
7. a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 3, wherein
Described nisin, the polylysine amount to be selected from from 0.05% to 0.1%, from 0.02% to 0.1% exists;
Described toothpaste matrix percentage by weight is as follows: Sorbitol 10 ~ 24%, hydrated silica 12 ~ 20%, glycerol 6 ~ 9%, sodium lauryl sulfate 1.8 ~ 2.5%, essence 0.8 ~ 1.2%, cellulose gum 0.8 ~ 1.0%, tetrasodium pyrophosphate 0.23 ~ 0.29%, saccharin sodium 0.22 ~ 0.28%, and surplus is water;
Its preparation method is as follows:
Nisin, polylysine are put into deionized water for stirring and dissolved, and mix with toothpaste matrix, send into three-in-one vacuum Manufacturing medicine extract machine, high-speed stirred grinds 30 minutes, vacuum outgas; Adding essence agitation grinding mixing in 15 minutes again, obtaining lotion of toothpaste, by packing after sterile filling.
8. a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 4, wherein
Described nisin, the polylysine amount to be selected from from 0.05% to 0.1%, from 0.02% to 0.1% exists;
Described collutory matrix weight percentage ratio is as follows: sodium chloride 0.2 ~ 0.3%, calcium chloride 0.05 ~ 0.15%, potassium chloride 0.2 ~ 0.3%, sodium hydrogen phosphate 0.05 ~ 0.15%, and surplus is water;
Its preparation method is as follows:
Nisin, polylysine are put into deionized water for stirring and dissolved, and after mixing with collutory substrate, high-speed stirred is dissolved to all substances, by packing after sterile filling.
9. a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 5, wherein
Described nisin, the polylysine amount to be selected from from 0.05% to 0.1%, from 0.02% to 0.05% exists;
Described refreshing tablets matrix weight percentage ratio is as follows: pulullan polysaccharide 16 ~ 18.0%, xanthan gum 0.02 ~ 0.04%, locust bean gum 0.06 ~ 0.08%, carrageenan 0.19 ~ 0.38%, glycerol 0.4 ~ 0.6%, acesulfame potassium and essence total amount 1.0 ~ 1.5%, Mentholum 1.5 ~ 3%, surplus are water;
Its preparation method is as follows:
After nisin, polylysine, pulullan polysaccharide, xanthan gum, locust bean gum, carrageenan fully being mixed, be dissolved in it 5 by the hot water of 70 ~ 80 DEG C of volume; Add glycerol and flavoring agent again, stir 2 ~ 3 hours, obtained glue; Vacuum degassing is steeped, and obtains film forming liquid; Be coated with film forming liquid scraper type coating device with on corrosion resistant plate, the THICKNESS CONTROL of film is at 20 ~ 30 μm; Steam drying, baking temperature is 80 ~ 90 DEG C; Demoulding.
10. a kind of oral cavity bacteriostatic composition containing nisin, polylysine according to claim 6, wherein
Described nisin, the polylysine amount to be selected from from 0.05% to 0.1%, from 0.02% to 0.1% exists;
Described chewing gum base percentage by weight is as follows: wheat gluten protein 60 ~ 70%, glycerol 5 ~ 8%, xylitol 1 ~ 2%, glyceryl monostearate 1.2 ~ 1.4%, citric acid 0.5 ~ 0.8%, Mentholum 0.15 ~ 0.3%, Konjac glucomannan 0.2 ~ 0.4%, acesulfame potassium 0.2 ~ 0.4%, essence 0.05 ~ 0.1%, surplus are water;
Its preparation method is as follows:
By the mixing of the deionized water of above-mentioned nisin, polylysine, glyceryl monostearate and 60 DEG C, abundant stirring and dissolving, obtains emulsion; The glycerol of above-mentioned mass fraction, xylitol, citric acid, Mentholum, Konjac glucomannan, acesulfame potassium, essence are added in the emulsion of insulation successively, obtains complex liquid; Joined while hot by complex liquid in the wheat gluten protein of above-mentioned mass fraction, obtain graininess dough after fully stirring evenly, room temperature is airtight leaves standstill 60 minutes, packs through rolling in flakes, after excision forming.
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390852A (en) * | 2016-11-14 | 2017-02-15 | 西安汇智医疗集团有限公司 | Antibacterial moisturizing liquid for respiratory ventilation treatment |
| CN106619193A (en) * | 2017-01-25 | 2017-05-10 | 江苏诺兴生物科技有限公司 | Antibacterial and whitening toothpaste and preparation method thereof |
| CN106726710A (en) * | 2016-12-22 | 2017-05-31 | 北京刷新活力健康科技有限公司 | A kind of effervescent tablet containing polylysine and parahydroxyacet-ophenone and preparation method and application |
| CN106924170A (en) * | 2017-04-17 | 2017-07-07 | 江苏恩为众心生物医药有限公司 | Probiotics cleans one's teeth gel production technology |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107080731A (en) * | 2017-04-17 | 2017-08-22 | 江苏恩为众心生物医药有限公司 | Probiotics periodontal nurses gel production technology |
| CN107242983A (en) * | 2017-06-15 | 2017-10-13 | 广州暨南生物医药研究开发基地有限公司 | A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof |
| CN107753931A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
| CN107753930A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and its application of nisin, Cetylpyridinium Chloride and sodium fluoride mouthwash |
| CN108096226A (en) * | 2018-01-12 | 2018-06-01 | 南阳师范学院 | A kind of film for treating oral ulcer containing polylysine and preparation method thereof |
| CN110522675A (en) * | 2019-10-12 | 2019-12-03 | 伟日（山东）生物科技有限公司 | Effectively antibacterial mouthwash and preparation method |
| CN110917074A (en) * | 2019-12-23 | 2020-03-27 | 湖州中科金羿医药科技有限公司 | Composition with antibacterial effect and application thereof in non-additive skin care products |
| CN111202069A (en) * | 2020-02-13 | 2020-05-29 | 军事科学院系统工程研究院卫勤保障技术研究所 | Disinfectant, and preparation method and application thereof |
| CN111471628A (en) * | 2020-06-04 | 2020-07-31 | 内蒙古农业大学 | New streptococcus and application of preparation thereof in inhibiting oral pathogenic bacteria |
| CN112245327A (en) * | 2020-11-27 | 2021-01-22 | 苏州承和记商贸有限公司 | Antibacterial composition, mouthwash and preparation method of mouthwash |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN115039842A (en) * | 2022-07-07 | 2022-09-13 | 卫仕宠物营养科学研究院(江苏)有限公司 | Functional food for eliminating halitosis of pet dogs and cats and preparation method and application thereof |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390852A (en) * | 2016-11-14 | 2017-02-15 | 西安汇智医疗集团有限公司 | Antibacterial moisturizing liquid for respiratory ventilation treatment |
| CN106726710A (en) * | 2016-12-22 | 2017-05-31 | 北京刷新活力健康科技有限公司 | A kind of effervescent tablet containing polylysine and parahydroxyacet-ophenone and preparation method and application |
| CN106619193A (en) * | 2017-01-25 | 2017-05-10 | 江苏诺兴生物科技有限公司 | Antibacterial and whitening toothpaste and preparation method thereof |
| CN106924170A (en) * | 2017-04-17 | 2017-07-07 | 江苏恩为众心生物医药有限公司 | Probiotics cleans one's teeth gel production technology |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107080731A (en) * | 2017-04-17 | 2017-08-22 | 江苏恩为众心生物医药有限公司 | Probiotics periodontal nurses gel production technology |
| CN107242983A (en) * | 2017-06-15 | 2017-10-13 | 广州暨南生物医药研究开发基地有限公司 | A kind of mouthwash of the flavones containing folium artemisiae argyi and preparation method thereof |
| CN107753930A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and its application of nisin, Cetylpyridinium Chloride and sodium fluoride mouthwash |
| CN107753931A (en) * | 2017-11-16 | 2018-03-06 | 江苏大学 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
| CN108096226A (en) * | 2018-01-12 | 2018-06-01 | 南阳师范学院 | A kind of film for treating oral ulcer containing polylysine and preparation method thereof |
| CN108096226B (en) * | 2018-01-12 | 2021-08-31 | 南阳师范学院 | Oral ulcer film containing polylysine and preparation method thereof |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110522675A (en) * | 2019-10-12 | 2019-12-03 | 伟日（山东）生物科技有限公司 | Effectively antibacterial mouthwash and preparation method |
| CN110917074A (en) * | 2019-12-23 | 2020-03-27 | 湖州中科金羿医药科技有限公司 | Composition with antibacterial effect and application thereof in non-additive skin care products |
| CN111202069A (en) * | 2020-02-13 | 2020-05-29 | 军事科学院系统工程研究院卫勤保障技术研究所 | Disinfectant, and preparation method and application thereof |
| CN111471628A (en) * | 2020-06-04 | 2020-07-31 | 内蒙古农业大学 | New streptococcus and application of preparation thereof in inhibiting oral pathogenic bacteria |
| CN111471628B (en) * | 2020-06-04 | 2022-02-15 | 内蒙古农业大学 | New streptococcus and application of preparation thereof in inhibiting oral pathogenic bacteria |
| CN112245327A (en) * | 2020-11-27 | 2021-01-22 | 苏州承和记商贸有限公司 | Antibacterial composition, mouthwash and preparation method of mouthwash |
| CN115039842A (en) * | 2022-07-07 | 2022-09-13 | 卫仕宠物营养科学研究院(江苏)有限公司 | Functional food for eliminating halitosis of pet dogs and cats and preparation method and application thereof |
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