CN107753931A - The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel - Google Patents
The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel Download PDFInfo
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- CN107753931A CN107753931A CN201711137811.6A CN201711137811A CN107753931A CN 107753931 A CN107753931 A CN 107753931A CN 201711137811 A CN201711137811 A CN 201711137811A CN 107753931 A CN107753931 A CN 107753931A
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- Prior art keywords
- nisin
- cetylpyridinium chloride
- sodium fluoride
- compound gel
- gel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Abstract
The invention discloses the preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel, belong to technical field of medicine.The raw material of compound gel is：0.01% nisin (NISIN), 0.05% Cetylpyridinium Chloride (CPC) and 0.1% sodium fluoride (NaF), remaining is xanthans.Compound gel has the function that important in dentistry, but its security and its repair ability on the surface of a wound influence its clinical effectiveness.Anti-inflammation compound gel involved in the present invention has obvious repair to canker sore, and it has security and the quick advantage for repairing the canker sore surface of a wound.
Description
Technical field
The invention belongs to technical field of medicine, is a kind of gel of anti-inflammation.
Background technology
Canker sore is a kind of disease of incidence of disease highest in the disease of cari oris mucosa, is apt to occur in lip, cheek, lingual margin etc., seriously
Influence quality of life.And the various bacteria such as Streptococcus mutans and Escherichia coli is also in close relations with canker sore.
Sodium fluoride can effectively prevent carious tooth with antibacterial, reduce bacterial plaque, widely applied to oral care production
Product.Cetylpyridinium Chloride is hexadecyl arsenic pyridine hydrate, belongs to cationic surfactant, mainly by reducing surface tension,
Increase the permeability of cell and suppress or kill bacterium, the auxiliary treatment currently used for mouth disease, it can also be used to daily mouth
Chamber is nursed.Because the physical property fusing point of Cetylpyridinium Chloride inherently is relatively low, volatile, different degrees of content occurs in its product
The phenomenon of decline, so as to influence its curative effect.
Nisin is the more skin classes of small molecule being made up of caused by lactic streptococcus strains fermentation individual amino acid
Compound, it can effectively suppress gram sun bacterium, the germ such as streptococcus mutans and Bacillus acidi lactici to causing carious tooth also have compared with
Strong inhibitory action.It is ratified as food preservative in existing multiple countries and regions, is used in canned food, vegetable protein food
In product, dairy products and meat products.By it is easily degraded by some protease in human body alimentary canal, will not be stored in human body
Product, is universally acknowledged safe natural antiseptic agent.At present, nisin not yet uses in oral care product, lactic acid
Streptostacin is used for mouthwash and needed developmental research.Most importantly, due to which it is a kind of more skins of small molecule, protect
Deposit the improper reduction for easily causing its activity or inactivation, it is therefore desirable to consider that add some stabilizers asks to solve its preservation
Topic.
Research shows that the unique alveolate texture of xanthans makes it have good security, stability, increases stiffness, vacation
Plasticity, while xanthans also acid and alkali-resistance, salt tolerant, resistance to enzymolysis and high temperature resistant, low-temperature resistance freezing, are current superior performances in the world
One of biogum, as stabilizer, be widely used in medicine, food, etc. various fields.
The content of the invention
It is an object of the invention in view of the deficienciess of the prior art, providing a kind of compound gel of composition containing anti-inflammation
And preparation method thereof, the compound gel main component nisin, it is natural bacteriostatic material, effectively can suppresses or kill
Go out intraoral various bacteria, while the compound gel with the addition of stabilizer xanthans, energy
Nisin and Cetylpyridinium Chloride are wrapped in its unique honeycomb, avoid the mistake of nisin
Living and Cetylpyridinium Chloride volatilization.And the compound gel can form layer protecting film when acting on oral cavity in oral cavity wound surface,
Extend active ingredient action time, Secondary bacterial infections can be prevented, so as to prevent as caused by mouth disease as bacteremia,
The systemic complications such as septicemia.
To achieve these goals, technical scheme provided by the invention is as follows：
The raw material of compound gel of the present invention is：0.01% nisin (NISIN), 0.05% Cetylpyridinium Chloride (CPC)
With 0.1% sodium fluoride (NaF), remaining is xanthans (mass percent meter).
It is an advantage of the present invention to provide compound gel of three kinds of effective bacteriostatic ingredients and preparation method thereof, the compound gel
While can cleaning oral cavity by the process gargled, the diseases such as antiphlogistic antibacterial effect, prophylactic treatment canker sore are originally played.
The active ingredient of invention is acted in oral cavity, can be suppressed or be killed microorganism, adjusts intraoral environment, and effectively anti-
Control multiple oral disease.For canker sore, the compound gel can be used to carry out local treatment in acute stage, compared to peroxide
Change conventional cleaning fluid, the compound gel formula such as hydrogen solution and contain natural antibacterial ingredient, may have more preferable anti-inflammation and
Therapeutic effect, and three kinds of active ingredients may have synergy, as compatibility is proper, while safely and effectively cleaning oral cavity,
Can the multiple oral disease such as effectively anti-treating dental ulcer.
Brief description of the drawings
Accompanying drawing 1：The change of different pharmaceutical treatment group mouse weight.
Accompanying drawing 2：Different pharmaceutical treatment group canker sore curative effect figure.
Accompanying drawing 3：Different pharmaceutical treatment group canker sore comprehensive grading.
Embodiment
Embodiment 1：Bacteriostatic experiment
Experimental strain：Escherichia coli, staphylococcus aureus, lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, variation
Streptococcus, actinobacillus actinomycetem comitans.
Bacterium culture medium：LB flat boards, CDC anaerobism blood plates, common blood plate and nutrient broth medium.
It is prepared by experimental group：Weigh 0.1g nisins and be dissolved in 100ml probiotics gargle blank (non-crystallising sorbitols
Alcohol, sodium benzoate, RH40 rilanit specials, propane diols, sodium fluoride, stay blue Mint Essence, light blue pigment, purified water), it is configured to
0.1% nisin solution, and 0.01% nisin is obtained by dilution；0.2g Cetylpyridinium Chlorides are weighed to be dissolved in
(Azulene sodium sulfonate gargle blank is Blank to 100ml Azulene sodium sulfonate gargles blank：Non-crystallising sorbitol, sodium benzoate,
RH40 rilanit specials, propane diols, stay blue Mint Essence, ethanol, purified water) in, be configured to 0.2% Cetylpyridinium Chloride solution,
And 0.05% Cetylpyridinium Chloride is obtained by dilution；Weigh 0.1g sodium fluorides and be dissolved in 100ml probiotics gargle blank, be configured to
0.1% sodium fluoride；Weigh 0.1g Azulene sodium sulfonates to be dissolved in 100ml Azulene sodium sulfonate gargle blank, be configured to 0.1% Azulene yellow acid
Sodium solution, and 0.03% Azulene sodium sulfonate is obtained by dilution.By 0.01% nisin solution obtained above, 0.05%
Cetylpyridinium Chloride solution and 0.1% Fluorinse are with 1:1:1 ratio mixing, obtains CPC NISIN NaF mixing groups；Will be above-mentioned
Obtained 0.01% nisin solution, 0.05% Cetylpyridinium Chloride solution, 0.1% Fluorinse and probiotics periodontal shield
Manage gel blank (non-crystallising sorbitol, sodium benzoate, RH40 rilanit specials, propane diols, sodium fluoride, American mint essence,
Sucralose, PEG-400, xanthans, sodium alginate, light blue pigment, purified water) with 1:1:1:1 ratio mixing, obtains CPC
NISIN NaF Gel groups；Obtain 0.03% Azulene yellow acid sodium solution obtained above and 0.05% Cetylpyridinium Chloride solution with 1:1
Ratio mixes, and obtains SAS CPC mixing groups；By 0.03% Azulene yellow acid sodium solution obtained above, 0.05% Cetylpyridinium Chloride solution
Gel blank is nursed with 1 with Azulene sodium sulfonate periodontal:1:1 proportional arrangement, obtain SAS CPC gel mixing groups；Blank groups are benefit
Raw bacterium gargle blank.
Specific experiment step：
Prepare bacterium solution：By Escherichia coli, staphylococcus aureus, lactobacillus acidophilus, Pseudomonas aeruginosa, Candida albicans, become
Different streptococcus, actinobacillus actinomycetem comitans strain are placed in 37 DEG C of culture 12h-18h in nutrient broth medium；Nutrient solution 1ml is taken to add
Enter 9ml 0.9% aseptic sodium chloride solution, using 10 times of incremental dilution methods, be diluted to 100cfu/ml, it is standby；
Uniformly mixed bacterium solution is tested made from above-mentioned steps in nutrient agar corresponding to every kind of bacterium, pour plate,
Cooling, punching, adds corresponding compound gel (having multiple holes) in hole；Flat board is inverted into incubator after 37 DEG C of cultures
24h, each medicine antibacterial circle diameter is measured, is then convert into antibacterial area；
Experimental observation measures：
S (antibacterial area)=S (measurement area)-S (perforated area)
Antibacterial area such as following table of the 0.05%CPC+0.01%NISIN+0.1%NaF groups to bacterium：
Antibacterial area such as following table of the 0.05%CPC+0.01%NISIN+0.1%NaF Gel groups to bacterium：
Antibacterial area such as following table of the 0.05%CPC+0.03%SAS groups to bacterium：
Antibacterial area such as following table of the 0.05%CPC+0.03%SAS Gel groups to bacterium：
Four kinds of formula of liquid of gargling do not have fungistatic effect to Escherichia coli, and to the fungistatic effect of staphylococcus aureus most
It is good.Considering proves that the compound gel of the present invention has more significant fungistatic effect, can play preferable antibacterial bacteriostatic effect
Fruit.
For a further understanding of the present invention, We conducted experiment in vivo.
Comparative example
Its raw material is：Blank (non-crystallising sorbitol, sodium benzoate, RH40 rilanit specials, propane diols, sodium fluoride,
Stay blue Mint Essence, light blue pigment, purified water).
Embodiment 2
A kind of anti-inflammation compound gel, the raw material that the compound gel is made are：0.01% nisin solution,
0.05% Cetylpyridinium Chloride solution and 0.1% Fluorinse.
Embodiment 3
A kind of anti-inflammation compound gel, the raw material that the compound gel is made are：0.01% nisin solution,
0.05% Cetylpyridinium Chloride solution, 0.1% Fluorinse and probiotics periodontal nursing gel blank.
Embodiment 4
A kind of anti-inflammation compound gel, the raw material that the compound gel is made are：0.03% Azulene yellow acid sodium solution and
0.05% Cetylpyridinium Chloride solution.
Embodiment 5
A kind of anti-inflammation compound gel, the raw material that the compound gel is made are：0.03% Azulene yellow acid sodium solution,
0.05% Cetylpyridinium Chloride solution and Azulene sodium sulfonate periodontal nursing gel blank.
40 ICR heros mouse (25-30g) are chosen, induce mucous membrane Oral ulcer model with 50% acetic acid (glacial acetic acid), it is random to divide
For 5 groups of (Blank groups, CPC+SAS groups, CPC+SAS Gel groups, CPC+NISIN+NaF groups and CPC+NISIN+NaF Gel mixing
Group), every group 8, every group of mouse carries out mark, and numbering is No. 1-8.The behavior of observation mouse and feed drinking-water situation daily,
The daily body weight of record mouse simultaneously carries out data analysis (see accompanying drawing 1).Observing surface of a wound situation includes size, the redness of ulcer simultaneously
Situation, whether there is grey pseudomembrane, whether there is diffusate, and comprehensive grading is carried out to the surface of a wound：The initial surface of a wound of 0- models, red and swollen, grey is false
Film；The 1- surface of a wound is not converged, and grey pseudomembrane comes off, and diffusate is obvious, red and swollen；The 1.5- surface of a wound is not converged, and red and swollen slight, diffusate subtracts
It is few；2- wound surface convergences, red and swollen slight, diffusate is less；2.5- wound surface convergences, a bit, diffusate is less for redness；The 3- surface of a wound is obvious
Diminish, a bit, redness is a bit for diffusate；The 3.5- surface of a wound substantially diminishes, no diffusate, and redness disappears；The 4- surface of a wound heals completely, number
See accompanying drawing 3 according to analysis.
In accompanying drawing 1, abscissa is number of days, and ordinate is relative mass -- using the quality of first day mouse as constant mass
Amount, it is relative again divided by obtained from the mouse quality of first day that the quality of the 2nd day to the 10th day subtracts the mouse quality of first day
Quality.Its data is subjected to statistical analysis.CPC+SAS groups, CPC+SAS Gel groups, CPC+NISIN+NaF groups and CPC+
The mouse weight of NISIN+NaF Gel groups increases for first day in medication, but the mouse increase of CPC+NISIN+NaF Gel groups is bright
Aobvious, the body weight of Blank group mouse is obvious in medication increase in the 3rd day.As a result show that CPC+NISIN+NaF Gel groups are obviously promoted
The healing of canker sore.
Blank groups have statistical significance (P=0.0283) with the contrast of CPC+NISIN+NaF Gel groups
In accompanying drawing 2, the visible obvious congestion and edema of the 3rd day five groups of murine oral mucous membranes, ulcer wound peripheral limit is unclear.
The murine oral ulcerated mucosa face of 6th day visible CPC+NISIN+NaF Gel group, which is obviously reduced, to shoal, it is seen that slight red and swollen and few
Diffusate is measured, CPC+SAS groups, CPC+SAS Gel groups, the murine oral ulcerated mucosa reduction of area of CPC+NISIN+NaF groups is small shoals,
It can be seen that slight red and swollen and a small amount of diffusate, Blank groups are red and swollen obvious, and diffusate is more.8th day visible CPC+NISIN+NaF
The mouse of Gel groups is without obvious ulcer surface, and consideration ulcer has healed, and CPC+SAS groups, CPC+SAS Gel groups, CPC+NISIN+
The murine lesion face of NaF groups, which diminishes, to shoal, and without red and swollen diffusate, the visible diffusate of mouse of PBS groups is slight red and swollen.10th day
It can be seen that the mouse of CPC+SAS groups, CPC+SAS Gel groups, CPC+NISIN+NaF groups considers that ulcer has been cured without obvious ulcer surface
Close.As a result show that CPC+NISIN+NaF Gel groups have been obviously promoted the healing of canker sore.
It is using abscissa as number of days, ordinate is commented for synthesis such as the comprehensive grading that accompanying drawing 3 is murine oral ulcer wound surface
Point, its data is subjected to statistical analysis and makes figure as above.The mouse of CPC+NISIN+NaF Gel groups after medication
The surface of a wound heals rapidly, and score highest.As a result show that CPC+NISIN+NaF Gel groups have been obviously promoted the healing of canker sore.
Test result indicates that compound gel sample of the invention can significantly mitigate murine oral ulcer acute inflammation swelling,
And the reparation of the canker sore surface of a wound is obviously promoted, has shown that there is the compound gel obvious anti-inflammatory reparation to make to acute inflammation
With.
It is described above, it is only the explanation embodiment of the present invention, formal and substantial limitation not any to the present invention,
It should be pointed out that for those skilled in the art, on the premise of the inventive method is not departed from, that makes some changes
Enter and supplement and also should be regarded as protection scope of the present invention.All those skilled in the art, the spirit of the present invention is not being departed from
In the case of scope, using disclosed above the technology contents a little dynamic modification made and the equivalent variations developed, it is
Simultaneously, what all substantial technologicals according to the present invention were done to above-described embodiment appoint the equivalent embodiment of the present invention and equivalent variations
Variation, modification and evolution, still fall within the scope of technical scheme.It is existing skill at the not detailed disclosure of the present invention
Art.
Claims (6)
1. nisin, Cetylpyridinium Chloride and sodium fluoride compound gel, its raw material are：0.01% nisin
(NISIN), 0.05% Cetylpyridinium Chloride (CPC) and 0.1% sodium fluoride (NaF), remaining is xanthans.
2. nisin according to claim 1, Cetylpyridinium Chloride and sodium fluoride compound gel are in canker sore
Pharmacologic action, it is characterised in that the application of nisin anti-inflammation in canker sore.
3. nisin according to claim 1, Cetylpyridinium Chloride and sodium fluoride compound gel are in canker sore
Pharmacologic action, it is characterised in that Cetylpyridinium Chloride is in canker sore in the application of anti-inflammation.
4. nisin according to claim 1, Cetylpyridinium Chloride and sodium fluoride compound gel are in canker sore
Pharmacologic action, it is characterised in that sodium fluoride is in canker sore in the application of anti-inflammation.
5. nisin according to claim 1, Cetylpyridinium Chloride and sodium fluoride compound gel are in canker sore
Pharmacologic action, it is characterised in that xanthans forms diaphragm on canker sore surface, prevents secondary infection.
6. nisin according to claim 1, Cetylpyridinium Chloride and sodium fluoride compound gel are in canker sore
Pharmacologic action, it is characterised in that nisin, Cetylpyridinium Chloride and sodium fluoride inhibit the growth of oral bacteria jointly, simultaneously
Promote the healing of canker sore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711137811.6A CN107753931A (en) | 2017-11-16 | 2017-11-16 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711137811.6A CN107753931A (en) | 2017-11-16 | 2017-11-16 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
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| CN107753931A true CN107753931A (en) | 2018-03-06 |
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| CN201711137811.6A Pending CN107753931A (en) | 2017-11-16 | 2017-11-16 | The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855580A (en) * | 2021-11-22 | 2021-12-31 | 广东艾慕生物科技有限公司 | Jelly-like mouth wash capable of melting in mouth and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748786A (en) * | 2005-09-13 | 2006-03-22 | 陈正跃 | Lactic streptostacin lozenge and its preparing method |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
| CN106924170A (en) * | 2017-04-17 | 2017-07-07 | 江苏恩为众心生物医药有限公司 | Probiotics cleans one's teeth gel production technology |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107080731A (en) * | 2017-04-17 | 2017-08-22 | 江苏恩为众心生物医药有限公司 | Probiotics periodontal nurses gel production technology |
-
2017
- 2017-11-16 CN CN201711137811.6A patent/CN107753931A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1748786A (en) * | 2005-09-13 | 2006-03-22 | 陈正跃 | Lactic streptostacin lozenge and its preparing method |
| CN105326656A (en) * | 2015-10-29 | 2016-02-17 | 山东省药学科学院 | Oral antibacterial composition containing nisin and polylysine and preparation method thereof |
| CN106924170A (en) * | 2017-04-17 | 2017-07-07 | 江苏恩为众心生物医药有限公司 | Probiotics cleans one's teeth gel production technology |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107080731A (en) * | 2017-04-17 | 2017-08-22 | 江苏恩为众心生物医药有限公司 | Probiotics periodontal nurses gel production technology |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855580A (en) * | 2021-11-22 | 2021-12-31 | 广东艾慕生物科技有限公司 | Jelly-like mouth wash capable of melting in mouth and preparation method thereof |
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