CN107693392A - A kind of toothpaste of enzyme-containing formulation and preparation method thereof - Google Patents
A kind of toothpaste of enzyme-containing formulation and preparation method thereof Download PDFInfo
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- CN107693392A CN107693392A CN201710131247.0A CN201710131247A CN107693392A CN 107693392 A CN107693392 A CN 107693392A CN 201710131247 A CN201710131247 A CN 201710131247A CN 107693392 A CN107693392 A CN 107693392A
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- enzyme
- toothpaste
- containing formulation
- lactoferrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of toothpaste of enzyme-containing formulation and preparation method thereof, and the toothpaste contains the combination of enzyme preparations thing being made up of de-sludging enzyme and suppression/sterilization enzyme.The toothpaste of present invention combination of enzyme preparations thing in shelf life is activity stabilized, and can guarantee that toothpaste self stability.The toothpaste of the present invention can effectively decompose the water-soluble dextran in tartar, the formation of pre- anti-tartar, and effectively remove tartar, while can substantially kill the mouth disease such as harmful bacteria, pre- anti-caries, gingivitis and periodontitis in oral cavity, so as to keep oral health.
Description
Technical field
The present invention relates to oral care techniques field, more particularly to application of the enzyme preparation in oral care product, specifically
It is related to a kind of toothpaste of enzyme-containing formulation and preparation method thereof.
Background technology
Enzyme is as a kind of biological agent, because with security is good, the high advantage of activity is progressively applied in tooth paste product.
At present, on the market enzyme preparation tooth paste product is increasingly universal, has been used for hemodia, bactericidal antiphlogistic, anti-caries, gingivitis and tooth
In tooth whitening, however can either remove tooth dirt again can effectively restraining and sterilizing bacteria enzyme preparation toothpaste it is also more rare.
A kind of soft yellow that tartar is attached on facing, dummy, calculus dentalis and gum linen compares bacterial plaque
The weak deposit of adhesion.At present, it is enzyme-added in toothpaste, it is exactly the catalysis using enzyme, makes the bacterial plaque matrix of indissoluble and food residual
Scorification is the hydrotrope, is dissolved in water when brushing teeth and gargling outside discharge oral cavity, can the pre- anti-caries of functions of whitening teeth and can and gingivitis
Etc. stomatopathy.
Natural anticorrosion antimicrobial component, it is always focus and the effort of oral care industry or even whole daily use chemicals industry research
Direction.Biological enzyme formulation such as lysozyme,, can be notable applied in some oral-cavity articles as the active component of natural antibacterial
Improve oral cavity oulitis situation, effectively suppress Periodontal Pathogens.
The stability of bioenzyme activity is its key problem in technology in oral care implement application study.Such as physical factor
(light, temperature, pressure), chemical factor (pH, electrolyte, ionic strength, oxidation and reduction) and the factor of production (enzyme degraded) etc. are all
There is a possibility that enzyme loss of activity.Oral care implement is complicated mixture, therefore, need to keep the same of enzymatic activity in shelf life
When, ensure the stability of product in itself, be the problem faced when biological enzyme formulation is applied in oral care implement.
Enzymatic activity is the key that enzyme preparation toothpaste makes success or failure.Enzymatic activity is extremely sensitive and change is rapid, therefore condition is slightly
Discomfort, the enzymatic activity in toothpaste will be made to reduce even complete deactivation.
Existing enzyme preparation toothpaste is primarily present following deficiency：
(1) in order to ensure the enzyme activity of enzyme-containing toothpaste, enzyme stabilizers or intensive need to be generally added, or the double groups of colour bar are made
The enzyme-containing toothpaste of part, solves the problems, such as that biology enzyme is incompatible with toothpaste other components such as surfactant.But need to separate cream processed,
The tedious steps such as independent packing.
(2) preventing decayed tooth of enzyme-containing toothpaste, antibacterial and other effects support without specific experimental data, and are tested without in-vitro method
Card, more using clinical appraisal test bacterial plaque, gingival index and anti-caries effect.
(3) it can effectively remove tartar while have the enzyme-containing toothpaste of bactericidal action also more rare.
(4) shelf life of enzyme-containing toothpaste has to be hoisted without substantially time limit, product quality.
The content of the invention
The purpose of the present invention is in view of the shortcomings of the prior art, there is provided a kind of preparation method is simple, enzymatic activity is high, and can
The formation of effective pre- anti-tartar simultaneously removes tartar, and and can kills the harmful levels of pathogens in oral cavity, safeguards the enzyme-containing formulation of oral health
Toothpaste.
It is a further object to provide the preparation method of above-mentioned enzyme-containing formulation toothpaste.
The above-mentioned purpose of the present invention is achieved by following scheme：
A kind of toothpaste of enzyme-containing formulation, the toothpaste include combination of enzyme preparations thing, and the combination of enzyme preparations thing is by de-sludging enzyme
Formed with suppression/sterilization enzyme；The de-sludging enzyme is dextranase, is preferably under the jurisdiction of α-dextranase of dextranase；The suppression/
Sterilization enzyme is glucose oxidase, lactoperoxidase, lactoferrin and lysozyme.
Above-mentioned combination of enzyme preparations thing accounts for the 0.05~0.5% of formulation of tooth-paste gross weight.
In above-mentioned combination of enzyme preparations thing, the weight ratio of de-sludging enzyme and suppression/sterilization enzyme is 1:10~10:1.
In above-mentioned combination of enzyme preparations thing, the weight ratio of glucose oxidase, lactoperoxidase and lactoferrin three is
1：1：1；The weight ratio of the glucose oxidase, the gross weight of lactoperoxidase and lactoferrin three and lysozyme is 1:
10~10:1.
The present inventor had found under study for action, and the activity of enzyme preparation is influenceed very big by lotion of toothpaste formula components, and lotion is matched somebody with somebody
The reasonably combined of square structure is directly connected to whether enzyme preparation can keep stable, is the key that lotion keeps high enzyme activity.
Therefore, on the basis of combination of enzyme preparations thing is established, the recipe ingredient of reasonable selection collocation optimization, is vital.
A kind of toothpaste of above-mentioned enzyme-containing formulation, the formula of its lotion of toothpaste are made up of following component：
Above-mentioned percentage is the percentage that each component accounts for total formula weight.
In above-mentioned formula, α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin and lysozyme are
The enzyme preparation of the present invention.Wherein, α-dextranase belongs to dextranase, can effectively remove the water-soluble Portugal in tartar and dental calculus
Glycan, so as to remove tooth dirt and prevent the formation of dental calculus；Glucose oxidase is one made from the fermentation such as aspergillus niger
Kind aerobic dehydrogenase, to human body without toxicity, side effect, have and remove the functions such as glucose, deoxidation, sterilization；Lactoperoxidase can
It is some other effectively to kill Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, bacillus subtilis, salmonella etc.
Harmful Gram-negative bacteria；Lactoferrin is a kind of natural activity glycoprotein with different physiological roles, belongs to wide spectrum suppression
Microbial inoculum, Gram-negative bacteria (such as Escherichia coli, salmonella) can be suppressed, can also suppress gram-positive bacteria (such as golden yellow
Staphylococcus, unicellular Listeria etc.)；Lysozyme can kill the streptococcus for facilitating carious tooth in oral cavity, Bacillus acidi lactici, thread
Harmful mushroom such as bacterium；α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin and the lysozyme are adopted
The present invention can be achieved with commercially available prod.
Above-mentioned Gantrez AN-119 is the abbreviation of methoxy ethylene/copolymer-maleic anhydride.
In above-mentioned formula, in order to keep the activity of combination of enzyme preparations thing, colloid system of the invention does not select antienzyme poor activity
Sodium carboxymethylcellulose, but use the combination of xanthans and Irish moss.
The present inventor has found that the laruyl alcohol sodium sulfovinate as anion surfactant can reduce enzyme preparation under study for action
The enzymatic activity of composition, but selection answers amphoteric surfactant such as Cocoamidopropyl betaine with laruyl alcohol sodium sulfovinate
After matching somebody with somebody, influence of the laruyl alcohol sodium sulfovinate to enzymatic activity can be substantially reduced, and also ensures the foaming properties of enzyme-containing toothpaste, from
And mouthfeel when can ensure the stability of enzyme activity and brush teeth.
The present invention also provides the preparation method of the toothpaste of above-mentioned enzyme-containing formulation, comprises the following steps：
Step 1
Saccharin sodium and sodium pyrophosphate are added in deionized water, stirs to being completely dissolved, then adds glycerine, sorb
Liquid phase is made in alcohol, PEG-8 and titanium dioxide, stirring 5min；
Silica, xanthans, Irish moss, Gantrez AN-119 are added in container and stirred, obtains mixed powder
Material；
Step 2
The mixed powder of step 1 is added in the liquid phase of step 1, after stirring 20min, adds essence, laruyl alcohol sulphur
Acid esters sodium, Cocoamidopropyl betaine, α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin, sulphur
Potassium cyanide and lysozyme, deaerated after stirring 15min, then the toothpaste of required enzyme-containing formulation is prepared.
The toothpaste of the enzyme-containing formulation of the present invention, which has, significantly goes tooth dirt effect, removes the experiment of artificial tooth dirt in vitro
In, α-dextranase need to only add 0.1%, you can reach 30% tooth dirt clearance.And the toothpaste can keep higher
Enzymatic activity, room temperature place 6 months after enzyme activity conservation rate be up to 100%.
Compared with prior art, the present invention has the advantages that：
1. the toothpaste of the enzyme-containing formulation of the present invention can effectively decompose the water-soluble dextran in tartar so that pre- anti-tartar
Formation and assist in removing tartar, while can substantially kill the harmful bacteria in oral cavity, pre- anti-caries, gingivitis and periodontitis
Etc. mouth disease, so as to keep oral health.
2. in the formulation of tooth-paste of the present invention, the dosage control to α-dextranase can ensure it most 0.01~0.1%
The excellent effect for removing tooth dirt, the effect of toothpaste decomposition removal tartar is poor if less than the dosage, and will not also be carried higher than the dosage
Rise toothpaste and remove the effect of tartar, and cost can be increased.
3. in the combination of enzyme preparations thing of the present invention, lysozyme, lacto-peroxidase system, lactoferrin carry out appropriate ratio
Compounded combination, by optimizing the compound proportion between several persons so as to reaching more preferable synergy.
4. bioactive substance is more easily damaged in toothpaste, not easy to maintain, should be noted to keep bioactivity in formula
Material and toothpaste basis have good compatibility.Therefore the formulation of tooth-paste of the present invention uses more preferable with enzyme preparation compatibility
Toothpaste component and dosage, ensure that toothpaste has higher enzymatic activity, while also ensure the stability of toothpaste in itself.
5. the factor for influenceing enzymatic activity has a lot, such as pH, temperature, electrolyte, therefore, the present inventor is in the exploitation present invention
Formulation of tooth-paste when, the compatibility except considering biology enzyme and toothpaste other compositions, it is also noted that other indexs of control toothpaste, are protected
The condition that demonstrate,proving high enzyme activity needs be in suitable scope, as water content, salt content can not be too high in formulation of tooth-paste, and it is of the invention
People adds Gantrez AN-119, and on the one hand the acid-base property of controllable toothpaste is in neutrality to slant acidity scope, can also postpone biology
The release of active component, effectively play the effect of the combination of enzyme preparations thing.
Embodiment
The present invention is further described through with reference to specific embodiment, but specific embodiment is not appointed to the present invention
What is limited.
Embodiment 1
A kind of toothpaste of enzyme-containing formulation of the present embodiment, the formula of its lotion of toothpaste are made up of following component：
Above-mentioned percentage is the percentage that each component accounts for total formula weight.
The preparation method of the toothpaste of above-mentioned enzyme-containing formulation, comprises the following steps：
Step 1
Saccharin sodium and sodium pyrophosphate are added in deionized water, stirs to being completely dissolved, then adds glycerine, sorb
Liquid phase is made in alcohol, PEG-8 and titanium dioxide, stirring 5min；
Silica, xanthans, Irish moss, Gantrez AN-119 are added in container and stirred, obtains mixed powder
Material；
Step 2
The mixed powder of step 1 is added in the liquid phase of step 1, after stirring 20min, adds essence, laruyl alcohol sulphur
Acid esters sodium, Cocoamidopropyl betaine, α-dextranase and lysozyme, deaerated after stirring 15min, then this reality is prepared
Apply the toothpaste of example.
Embodiment 2
A kind of toothpaste of enzyme-containing formulation of the present embodiment, the formula of its lotion of toothpaste are made up of following component：
Above-mentioned percentage is the percentage that each component accounts for total formula weight.
The preparation method of the toothpaste of above-mentioned enzyme-containing formulation, comprises the following steps：
Step 1
Saccharin sodium and sodium pyrophosphate are added in deionized water, stirs to being completely dissolved, then adds glycerine, sorb
Liquid phase is made in alcohol, PEG-8 and titanium dioxide, stirring 5min；
Silica, xanthans, Irish moss, Gantrez AN-119 are added in container and stirred, obtains mixed powder
Material；
Step 2
The mixed powder of step 1 is added in the liquid phase of step 1, after stirring 20min, adds essence, laruyl alcohol sulphur
It is acid esters sodium, Cocoamidopropyl betaine, α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin, molten
Bacterium enzyme and potassium rhodanate, deaerated after stirring 15min, then the toothpaste of the present embodiment is prepared.
Embodiment 3
A kind of toothpaste of enzyme-containing formulation of the present embodiment, the formula of its lotion of toothpaste are made up of following component：
Above-mentioned percentage is the percentage that each component accounts for total formula weight.
The preparation method of the toothpaste of above-mentioned enzyme-containing formulation, comprises the following steps：
Step 1
Saccharin sodium and sodium pyrophosphate are added in deionized water, stirs to being completely dissolved, then adds glycerine, sorb
Liquid phase is made in alcohol, PEG-8 and titanium dioxide, stirring 5min；
Silica, xanthans, Irish moss, Gantrez AN-119 are added in container and stirred, obtains mixed powder
Material；
Step 2
The mixed powder of step 1 is added in the liquid phase of step 1, after stirring 20min, adds essence, laruyl alcohol sulphur
It is acid esters sodium, Cocoamidopropyl betaine, α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin, molten
Bacterium enzyme and potassium rhodanate, deaerated after stirring 15min, then the toothpaste of the present embodiment is prepared.
The embodiment 1-3 of embodiment 4 stability test
By embodiment 1-3 toothpaste respectively at a temperature of 45 DEG C after accelerated ageing 3 months, detection product correlation items refer to
Mark.Testing result is as shown in table 1.
Evaluation criterion：
1. organoleptic indicator's lotion：Uniformly, foreign.
2. physical and chemical index pH:5.5-10.0；Stability：Lotion does not spill over the mouth of pipe, does not isolate liquid, fragrance color and luster is just
Often.
The stability experiment result of the embodiment 1-3 toothpaste of table 1
From the results shown in Table 1, the tooth paste product resistance to overturning of the invention containing the combination of enzyme preparations thing is good,
Good quality.
The announcement and teaching of book according to the above description, those skilled in the art in the invention can also be to above-mentioned embodiment party
Formula is changed and changed.Therefore, the invention is not limited in embodiment disclosed and described above, to the present invention's
Some modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although used in this specification
Some specific terms, but these terms are merely for convenience of description, do not form any restrictions to the present invention.
Claims (6)
1. a kind of toothpaste of enzyme-containing formulation, it is characterised in that the toothpaste includes combination of enzyme preparations thing, and the combination of enzyme preparations thing accounts for tooth
The 0.05~0.5% of paste formulation gross weight, the combination of enzyme preparations thing are made up of de-sludging enzyme and suppression/sterilization enzyme.
2. the toothpaste of enzyme-containing formulation according to claim 1, it is characterised in that the de-sludging enzyme is dextranase, the suppression/
Sterilization enzyme is the weight of glucose oxidase, lactoperoxidase, lactoferrin and lysozyme, the de-sludging enzyme and suppression/sterilization enzyme
Amount is than being 1:10~10:1.
3. the toothpaste of enzyme-containing formulation according to claim 2, it is characterised in that the de-sludging enzyme is α-dextranase.
4. the toothpaste of enzyme-containing formulation according to claim 2, it is characterised in that the glucose oxidase, lactoperoxidase
Weight ratio with lactoferrin three is 1：1：1, the glucose oxidase, lactoperoxidase and lactoferrin three it is total
Weight and the weight of lysozyme ratio are 1:10~10:1.
5. the toothpaste of any one enzyme-containing formulation according to claim 1-4, it is characterised in that formulation of tooth-paste percentage by weight
Than meter, it is made up of following component：
6. the preparation method of toothpaste described in a kind of claim 5, it is characterised in that this method comprises the following steps：
Step 1
Saccharin sodium and sodium pyrophosphate are added in deionized water, stirred to being completely dissolved, glycerine, sorbierite is then added, gathers
Liquid phase is made in ethylene glycol -8 and titanium dioxide, stirring 5min；
Silica, xanthans, Irish moss, Gantrez AN-119 are added in container and stirred, obtains mixed powder；
Step 2
The mixed powder of step 1 is added in the liquid phase of step 1, after stirring 20min, adds essence, bay alcohol sulfuric ester
Sodium, Cocoamidopropyl betaine, α-dextranase, glucose oxidase, lactoperoxidase, lactoferrin, thiocyanation
Potassium and lysozyme, deaerated after stirring 15min, then the toothpaste of required enzyme-containing formulation is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710131247.0A CN107693392B (en) | 2017-03-07 | 2017-03-07 | Toothpaste containing enzyme preparation and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710131247.0A CN107693392B (en) | 2017-03-07 | 2017-03-07 | Toothpaste containing enzyme preparation and preparation method thereof |
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| CN107693392B CN107693392B (en) | 2020-11-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578268A (en) * | 2018-06-21 | 2018-09-28 | 广州康云生物科技有限公司 | a kind of toothpaste containing lysozyme |
| CN111558033A (en) * | 2020-05-14 | 2020-08-21 | 广州中昱医学生物科技有限公司 | Oral cavity cleaning composition and application thereof |
| CN112190499A (en) * | 2020-11-12 | 2021-01-08 | 好易康生物科技(广州)有限公司 | Lysozyme oral care product for whitening teeth |
| CN112336658A (en) * | 2019-08-09 | 2021-02-09 | 滕敏子 | Dental caries preventing ice cream toothpaste without fluorine and preparation process thereof |
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|---|---|---|---|---|
| FR2651433A1 (en) * | 1989-09-07 | 1991-03-08 | Dana Dominique | Enzyme complex having activity with respect to tartar and dental caries |
| EP1449513A1 (en) * | 2003-02-19 | 2004-08-25 | Sara Lee/DE N.V. | Dental care product |
| CN105163705A (en) * | 2013-02-14 | 2015-12-16 | 荷兰联合利华有限公司 | Non-aqueous oral care compositions |
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2017
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| FR2651433A1 (en) * | 1989-09-07 | 1991-03-08 | Dana Dominique | Enzyme complex having activity with respect to tartar and dental caries |
| EP1449513A1 (en) * | 2003-02-19 | 2004-08-25 | Sara Lee/DE N.V. | Dental care product |
| CN105163705A (en) * | 2013-02-14 | 2015-12-16 | 荷兰联合利华有限公司 | Non-aqueous oral care compositions |
| CN105456041A (en) * | 2015-12-11 | 2016-04-06 | 广州薇美姿实业有限公司 | Toothpaste containing particles and transparent viscous substance |
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| Title |
|---|
| 刘怡然等: ""隆力奇DL复合酶牙膏对部分口腔微生物体外抑菌作用的实验研究"", 《口腔生物医学》 * |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578268A (en) * | 2018-06-21 | 2018-09-28 | 广州康云生物科技有限公司 | a kind of toothpaste containing lysozyme |
| CN108578268B (en) * | 2018-06-21 | 2019-07-23 | 广州康云生物科技有限公司 | A kind of toothpaste containing lysozyme |
| CN112336658A (en) * | 2019-08-09 | 2021-02-09 | 滕敏子 | Dental caries preventing ice cream toothpaste without fluorine and preparation process thereof |
| CN111558033A (en) * | 2020-05-14 | 2020-08-21 | 广州中昱医学生物科技有限公司 | Oral cavity cleaning composition and application thereof |
| CN112190499A (en) * | 2020-11-12 | 2021-01-08 | 好易康生物科技(广州)有限公司 | Lysozyme oral care product for whitening teeth |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107693392B (en) | 2020-11-06 |
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