CN106924170A - Probiotics cleans one's teeth gel production technology - Google Patents

Probiotics cleans one's teeth gel production technology Download PDF

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CN106924170A
CN106924170A CN201710248377.2A CN201710248377A CN106924170A CN 106924170 A CN106924170 A CN 106924170A CN 201710248377 A CN201710248377 A CN 201710248377A CN 106924170 A CN106924170 A CN 106924170A
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weight
percentage composition
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江晶晶
张振平
周建兵
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Jiangsu Grace For Heart Biotechnology Co Ltd
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Jiangsu Grace For Heart Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

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  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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Abstract

Cleaned one's teeth gel production technology the invention discloses probiotics, configure solution I：Purified water heating is added into Sodium Benzoate, Cetylpyridinium Chloride, sodium fluoride and Sucralose, nisin, light blue pigment；Configuration solution II：RH40 rilanit specials, propane diols are heated to melting, American mint essence is added；Configuration solution III：To non-crystallising sorbitol is added in vacuum kettle, after PEG 400, xanthans and sodium alginate are stirred, solution III is obtained；Solution II is added in solution I, is stirred, to adding non-crystallising sorbitol in vacuum kettle, again to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle, adds sodium lauroyl sarcosine, sample examination Cetylpyridinium Chloride, semi-finished product are qualified rear canned；Finished product detection warehousing after passing, it is unqualified discarded.Probiotics of the invention cleans one's teeth gel production technology, by configuring three solution, obtains Cetylpyridinium Chloride semi-finished product, lactobacillus can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, the bacterial plaque reduced on tooth is piled up, the generation of prevention of gingivitis and carious tooth, improves oral cavity flora balance.

Description

Probiotics cleans one's teeth gel production technology
Technical field
Cleaned one's teeth gel production technology the present invention relates to a kind of probiotics.
Background technology
General utility functions are imitated toothpaste addition antibiotic and suppress oral cavity germ entirely, and long-term use antibiotic, germ easily produces The raw resistance to the action of a drug, and general utility functions toothpaste is single to the care benefits of oral cavity and tooth, lacks comprehensive nursing function.Typically Enzyme preparation toothpaste can not control the decay of enzymatic activity, it cannot be guaranteed that the activity of enzyme within the shelf-life, so as to can not reach real Using effect, the protective effect reduction to oral cavity and tooth.
Accordingly, it is desirable to provide a kind of new technical scheme solves the above problems.
The content of the invention
The probiotics that it is good that the technical problem to be solved in the present invention is to provide a kind of nursing efficacy cleans one's teeth gel production technology.
The gel production technology in order to solve the above technical problems, present invention offer probiotics cleans one's teeth, comprises the following steps：
（a）Configuration solution I：The purified water of weight/mass percentage composition 65%-75% is heated to 35 DEG C -40 DEG C, adds quality percentage to contain Sodium Benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.045% ~ 0.055%, the weight/mass percentage composition 0.04% of amount 0.45% ~ 0.55% ~ 0.06% sodium fluoride, the Sucralose of weight/mass percentage composition 0.045% ~ 0.055%, weight/mass percentage composition 0.0035% ~ 0.0065% nisin, the light blue pigment of weight/mass percentage composition 0.0016% ~ 0.0002%, stirs 20-25 minutes, stirring Uniformly, solution I is obtained；
（b）Configuration solution II：By the RH40 rilanit specials of weight/mass percentage composition 1.6% ~ 2.4%, weight/mass percentage composition 1.6% ~ 2.4% propane diols is heated to melting, adds the American mint essence of weight/mass percentage composition 0.64% ~ 0.96%, stirs, and obtains To solution II；
（c）Configuration solution III：By formula rate, to the non-crystallising sorbitol that weight/mass percentage composition 9% ~ 21% is added in vacuum kettle （Content is 70%）, by the PEG-400 of weight/mass percentage composition 4% ~ 6%, the xanthans of weight/mass percentage composition 0.7% ~ 1.3% and quality After the sodium alginate of percentage composition 0.7% ~ 1.3% stirs, solution III is obtained；
（d）Solution II is added in solution I, is stirred, to the non-knot that weight/mass percentage composition 9% ~ 21% is added in vacuum kettle Brilliant D-sorbite（Content is 70%）, then to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle In, high-speed stirred 10-15 minutes is vacuumized into colloid, add the lauroyl flesh ammonia of weight/mass percentage composition 2.64% ~ 3.96% Sour sodium（30%）, vacuumize high-speed stirred 10-15 minutes and form semi-finished product, sample examination Cetylpyridinium Chloride, the qualified rear tank of semi-finished product Dress；What Cetylpyridinium Chloride was not enough, Cetylpyridinium Chloride is added, to stir 25-30 minutes, sampling detection is qualified to semi-finished product, starts filling；Into Warehousing after passing is surveyed in product examine, unqualified discarded.
Beneficial effects of the present invention：Lactobacillus can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, reduce tooth On bacterial plaque pile up, the generation of prevention of gingivitis and carious tooth, improve oral cavity flora balance.
Specific embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, the embodiment It is only used for explaining the present invention, does not constitute the restriction to protection scope of the present invention.
Embodiment 1
Probiotics cleans one's teeth gel production technology, comprises the following steps：
（a）Configuration solution I：The purified water of weight/mass percentage composition 68.4516% is heated to 35 DEG C -40 DEG C, adds quality percentage to contain Sodium Benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.049%, the sodium fluoride of weight/mass percentage composition 0.052%, the matter of amount 0.49% Measure Sucralose, the nisin of weight/mass percentage composition 0.0052%, the weight/mass percentage composition of percentage composition 0.052% 0.00018% light blue pigment, stirs 20-25 minutes, stirs, and obtains solution I；
（b）Configuration solution II：By the RH40 rilanit specials of weight/mass percentage composition 1.8%, the propane diols of weight/mass percentage composition 1.8% Melting is heated to, the American mint essence of weight/mass percentage composition 0.8% is added, stirred, obtain solution II；
（c）Configuration solution III：By formula rate, to the non-crystallising sorbitol that weight/mass percentage composition 15.8% is added in vacuum kettle （Content is 70%）, the PEG-400 of weight/mass percentage composition 5.2%, the xanthans of weight/mass percentage composition 1.0% and quality percentage are contained After the sodium alginate of amount 1.0% stirs, solution III is obtained；
（d）Solution II is added in solution I, is stirred, in vacuum kettle add weight/mass percentage composition 15.8% it is noncrystalline D-sorbite（Content is 70%）, then to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle In, high-speed stirred 10-15 minutes is vacuumized into colloid, add the sodium lauroyl sarcosine of weight/mass percentage composition 3.5% （30%）, vacuumizing high-speed stirred 10-15 minutes and form semi-finished product, sample examination Cetylpyridinium Chloride, semi-finished product are qualified rear canned；West What pyrrole oronain was not enough, Cetylpyridinium Chloride is added, to stir 25-30 minutes, sampling detection is qualified to semi-finished product, starts filling；Into product examine Warehousing after passing is surveyed, it is unqualified discarded.
Embodiment 2
Probiotics cleans one's teeth gel production technology, comprises the following steps：
（a）Configuration solution I：The purified water of weight/mass percentage composition 69.7533% is heated to 35 DEG C -40 DEG C, adds quality percentage to contain Sodium Benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.055%, the sodium fluoride of weight/mass percentage composition 0.06%, the quality of amount 0.55% The Sucralose of percentage composition 0.055%, the nisin of weight/mass percentage composition 0.0065%, weight/mass percentage composition 0.0002% light blue pigment, stirs 20-25 minutes, stirs, and obtains solution I；
（b）Configuration solution II：By the RH40 rilanit specials of weight/mass percentage composition 2.0%, the propane diols of weight/mass percentage composition 2.0% Melting is heated to, the American mint essence of weight/mass percentage composition 0.96% is added, stirred, obtain solution II；
（c）Configuration solution III：By formula rate, to the non-crystallising sorbitol that weight/mass percentage composition 12% is added in vacuum kettle（Contain Measure is 70%）, by the PEG-400 of weight/mass percentage composition 6%, the xanthans of weight/mass percentage composition 1.3% and weight/mass percentage composition 1.3% Sodium alginate stir after, obtain solution III；
（d）Solution II is added in solution I, is stirred, to the noncrystalline mountain that weight/mass percentage composition 12% is added in vacuum kettle Pears sugar alcohol（Content is 70%）, then to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle, High-speed stirred 10-15 minutes is vacuumized into colloid, the sodium lauroyl sarcosine of weight/mass percentage composition 3.96% is added（30%）, Vacuumize high-speed stirred 10-15 minutes and form semi-finished product, sample examination Cetylpyridinium Chloride, semi-finished product are qualified rear canned；Cetylpyridinium Chloride Not enough, Cetylpyridinium Chloride is added, to stir 25-30 minutes, sampling detection is qualified to semi-finished product, starts filling；Finished product detection is qualified After be put in storage, it is unqualified discarded.
Embodiment 3
Probiotics cleans one's teeth gel production technology, comprises the following steps：
（a）Configuration solution I：The purified water of weight/mass percentage composition 66.5663% is heated to 35 DEG C -40 DEG C, adds quality percentage to contain Sodium Benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.045%, the sodium fluoride of weight/mass percentage composition 0.04%, the quality of amount 0.45% The Sucralose of percentage composition 0.045%, the nisin of weight/mass percentage composition 0.0035%, weight/mass percentage composition 0.00016% light blue pigment, stirs 20-25 minutes, stirs, and obtains solution I；
（b）Configuration solution II：By the RH40 rilanit specials of weight/mass percentage composition 1.6%, the propane diols of weight/mass percentage composition 1.6% Melting is heated to, the American mint essence of weight/mass percentage composition 0.64% is added, stirred, obtain solution II；
（c）Configuration solution III：By formula rate, to the non-crystallising sorbitol that weight/mass percentage composition 21% is added in vacuum kettle（Contain Measure is 70%）, by the PEG-400 of weight/mass percentage composition 4%, the xanthans of weight/mass percentage composition 0.7% and weight/mass percentage composition 0.7% Sodium alginate stir after, obtain solution III；
（d）Solution II is added in solution I, is stirred, to the noncrystalline mountain that weight/mass percentage composition 21% is added in vacuum kettle Pears sugar alcohol（Content is 70%）, then to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle, High-speed stirred 10-15 minutes is vacuumized into colloid, the sodium lauroyl sarcosine of weight/mass percentage composition 2.64% is added（30%）, Vacuumize high-speed stirred 10-15 minutes and form semi-finished product, sample examination Cetylpyridinium Chloride, semi-finished product are qualified rear canned；Cetylpyridinium Chloride Not enough, Cetylpyridinium Chloride is added, to stir 25-30 minutes, sampling detection is qualified to semi-finished product, starts filling；Finished product detection is qualified After be put in storage, it is unqualified discarded.
It is nisin, sodium fluoride and Cetylpyridinium Chloride, nisin that the probiotics cleans one's teeth and nurses gel primary efficacy The synergy of rhzomorph and sodium fluoride, the effect for preferably reaching preventing decayed tooth bacterium and the balance for maintaining oral cavity flora, add Cetylpyridinium Chloride, suppresses bacterial plaque and periodontal bacteria, particularly porphyromonas gingivalis, so that alleviate periodontitis, gingivitis.It is above-mentioned Several compositions, can suppress most bacteriums in oral cavity, safeguard oral health.
Step（a）Middle configuration solution I, Sodium Benzoate：It is a kind of good food preservative, the effect for extending the shelf life； Cetylpyridinium Chloride：Belong to cationic surfactant, by reducing surface tension, increase the permeability of cell membrane, so as to suppress With killing bacterium, it can be adsorbed in mucous membrane of mouth, and nonirritant to mucous membrane of mouth, not colored to facing, have antibacterial to bacterium Effect, can reduce bacterial plaque and be formed, and the health care in oral cavity is widely used in abroad；Sodium fluoride：It is to the various enzymes in oral cavity There is inhibitory action, bacterial plaque can be reduced with antibacterial, the solubility of hydroxyapatite in enamel can be reduced, increase the anti-caries of tooth Power, can also promote the integrality of enamel, increase the hardness of enamel；Sucralose：It is a kind of sweetener, enhances mouthfeel effect Really, its is stable in properties, water-soluble preferable；Nisin：It is a kind of natural products with very strong bactericidal effect, it is disturbed The normal function of bacterial cell membrane in oral cavity, destroys the integrality of cell, particularly some cariogenic bacterias, such as Streptococcus mutans, from And the balance of oral cavity flora is maintained, the oral health of let us；Light blue pigment：It is a kind of colouring agent, allows product to have and preferably regard Feel sense.
Step（b）Middle configuration solution II, American mint essence can well dissolve in the presence of rilanit special, from property Looked on shape clear, adding propane diols can preferably play effect of moisturizing.
Step（c）Middle configuration solution III, because xanthans and sodium alginate have emulsification so that above two is molten Liquid becomes sticky, adds PEG-400 that each component can be made to reach good compatibility.Non-crystallising sorbitol：Be both NMF again It is sweetener, moistening effect is gentleer, and taste is also fine.Non-crystallising sorbitol is added in solution III, contributes to xanthans Dissolved with sodium alginate.
Probiotics of the invention cleans one's teeth gel production technology, by configuring three solution, obtains Cetylpyridinium Chloride semi-finished product, newborn bar Bacterium can strengthen inhibitory action of the sodium fluoride to Streptococcus mutans, reduce the bacterial plaque accumulation on tooth, prevention of gingivitis and dental caries The generation of tooth, improves oral cavity flora balance.

Claims (1)

1. probiotics cleans one's teeth gel production technology, it is characterised in that comprise the following steps：
（a）Configuration solution I：The purified water of weight/mass percentage composition 65%-75% is heated to 35 DEG C -40 DEG C, adds quality percentage to contain Sodium Benzoate, the Cetylpyridinium Chloride of weight/mass percentage composition 0.045% ~ 0.055%, the weight/mass percentage composition 0.04% of amount 0.45% ~ 0.55% ~ 0.06% sodium fluoride, the Sucralose of weight/mass percentage composition 0.045% ~ 0.055%, weight/mass percentage composition 0.0035% ~ 0.0065% nisin, the light blue pigment of weight/mass percentage composition 0.0016% ~ 0.0002%, stirs 20-25 minutes, stirring Uniformly, solution I is obtained；
（b）Configuration solution II：By the RH40 rilanit specials of weight/mass percentage composition 1.6% ~ 2.4%, weight/mass percentage composition 1.6% ~ 2.4% propane diols is heated to melting, adds the American mint essence of weight/mass percentage composition 0.64% ~ 0.96%, stirs, and obtains To solution II；
（c）Configuration solution III：By formula rate, to the non-crystallising sorbitol that weight/mass percentage composition 9% ~ 21% is added in vacuum kettle Alcohol, by the PEG-400 of weight/mass percentage composition 4% ~ 6%, the xanthans and weight/mass percentage composition of weight/mass percentage composition 0.7% ~ 1.3% After 0.7% ~ 1.3% sodium alginate stirs, solution III is obtained；
（d）Solution II is added in solution I, is stirred, to the non-knot that weight/mass percentage composition 9% ~ 21% is added in vacuum kettle Brilliant D-sorbite, then to solution III is added in vacuum kettle, the mixed liquor of solution I, solution II is extracted into vacuum kettle, vacuumize height Speed stirring adds the sodium lauroyl sarcosine of weight/mass percentage composition 2.64% ~ 3.96% in 10-15 minutes into colloid, vacuumizes Form semi-finished product within high-speed stirred 10-15 minutes, sample examination Cetylpyridinium Chloride, semi-finished product are qualified rear canned；What Cetylpyridinium Chloride was not enough, Addition Cetylpyridinium Chloride, stirs 25-30 minutes, and sampling detection is qualified to semi-finished product, starts filling；Finished product detection warehousing after passing, It is unqualified discarded.
CN201710248377.2A 2017-04-17 2017-04-17 Probiotics cleans one's teeth gel production technology Pending CN106924170A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753931A (en) * 2017-11-16 2018-03-06 江苏大学 The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel
CN109018663A (en) * 2018-08-31 2018-12-18 沈杨 There is the sucker toothpaste of decorative effect
US11304888B2 (en) 2019-04-29 2022-04-19 Sunstar Americas, Inc. Oral care composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104666185A (en) * 2015-02-13 2015-06-03 成都润兴消毒药业有限公司 Liquid toothpaste and preparation method thereof
CN105326656A (en) * 2015-10-29 2016-02-17 山东省药学科学院 Oral antibacterial composition containing nisin and polylysine and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104666185A (en) * 2015-02-13 2015-06-03 成都润兴消毒药业有限公司 Liquid toothpaste and preparation method thereof
CN105326656A (en) * 2015-10-29 2016-02-17 山东省药学科学院 Oral antibacterial composition containing nisin and polylysine and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753931A (en) * 2017-11-16 2018-03-06 江苏大学 The preparation and application of nisin, Cetylpyridinium Chloride and sodium fluoride compound gel
CN109018663A (en) * 2018-08-31 2018-12-18 沈杨 There is the sucker toothpaste of decorative effect
US11304888B2 (en) 2019-04-29 2022-04-19 Sunstar Americas, Inc. Oral care composition

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