CN105534875B - Antibacterial antiallergic perception compositions and its toothpaste and preparation method for oral-cavity article - Google Patents
Antibacterial antiallergic perception compositions and its toothpaste and preparation method for oral-cavity article Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses a kind of antibacterial antiallergic perception compositions for oral-cavity article, comprising anti-sensitive agent and probiotics, the anti-sensitive agent includes at least one of sylvite and/or strontium salt.Also disclose application of the antibacterial antiallergic perception compositions in toothpaste, liquid tooth paste, mouthwash, tooth powder, tooth gel or chewing gum.A kind of antibacterial antiallergic sense toothpaste and preparation method thereof is also disclosed, the toothpaste includes NMF, rubbing agent, thickener, surfactant, sweetener, essence and water, also comprising antibacterial antiallergic perception compositions；Its preparation method adds thickener and quickly stirred, then sequentially add rubbing agent, surfactant, sweetener, sylvite and/or strontium salt, add probiotics, and uniform stirring to add NMF in a reservoir first；Then vacuumize, be eventually adding essence, stir homogeneous, degassing, obtain product.The present invention can help user to solve the symptoms such as bleeding gums, halitosis, tooth mobility, sensitivity of tooth.
Description
Technical field
The present invention relates to the composition for oral-cavity article, and in particular to a kind of antibacterial antiallergic sense group for oral-cavity article
Compound and its toothpaste and preparation method.
Background technology
Gingivitis is a kind of mankind's most widely oral cavity chronic disease, with the development of society, the dietary structure of people occurs
Change, exquisite food make sensitiveness increase of the tooth to gingivitis, cause the symptoms such as swelling and aching of gum, bleeding gums.20th century
Before the seventies, the rate of gingivitis is in rising trend always, is related to each corner with throughout world.
Periodontosis is that the disease in tooth surrounding tissue occurs, and is broadly divided into gingivitis and periodontitis, wherein gingivitis master
Gingiva tissue is destroyed, periodontitis lesion mainly invades gum, parodontium, alveolar bone and cementum.Periodontosis can cause gum
Bleeding, halitosis, tooth mobility and displacement etc..
Probiotics is a kind of microorganism beneficial to human body, can be taken directly as food additives, with maintain oral cavity and
Intestines and stomach bacterium colony balances, and is used for yoghurt, yogurt, Fermented Soybean Milk and a variety of probiotics oral liquids, tablet, capsule, powder
Agent etc..
Probiotics can secrete organic acid, a variety of antibacterial materials such as hydrogen peroxide and bacterium, so as to suppress the growth of germ；
Or the binding site with pathogenic bacteria competition mucomembranous surface, reduce the field planting of pathogenic bacteria；By adjusting pH value and oxidation-reduction potential,
Change microorganism ecological environment, be allowed to maintain in suitable scope；Nonspecific immune reaction and regulation body fluid can also be stimulated
Immune and cellular immunity, to play prebiotic effect.
Using the bacterium phase of probiotics regulation oral microorganism, to reach the purpose of oral health this conception of species in academia
Row for many years, and existing many clinical tests show the feasibility of this mode, and it is mostly Bacillus acidi lactici, and has many bacterium
Strain clinically confirms to have to be reduced gingivitis or suppresses to turn the phenomenon of pool streptococcus growth, wherein saliva Bacillus acidi lactici or secondary dry
Lactobacillus casei has certain effect for prevention periodontosis with reducing halitosis.Research find lactobacillus fermenti, Lactobacillus plantarum,
These conventional oral cavity lactic acid of Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus acidophilus, Lactobacillus casei or secondary cheese lactic acid bacteria
Bacterium to anti-caries bacterium, can reduce the quantity of saliva streptococcus mutans.In a word, Bacillus acidi lactici class probiotics can be colonized in oral cavity for
Maintain the oral cavity ecological balance to play a significant role, the generation possibility of bacterial plaque is reduced, so as to reduce the illness of gingivitis, periodontosis
Rate.Often mainly there are sylvite and strontium salt in oral cavity with desensitizer, and wherein strontium salt desensitization refers to that strontium can act on life with the calcium carbonate in dentine
Into strontium carbonate SrCO3, while hydroxyl saamite is generated with the hydroxyapatite effect of dentine, obstruction dentine opens small
Pipe.Sylvite desensitization, which refers to potassium ion, can enter the permeability of dentinal tubule reduction dentine, and have affinity interaction with nerve endings,
Improve the transmission of nerve impulse, slow down dental pain.
Generally speaking, probiotics, which has, maintains the oral cavity ecological balance to play a significant role, and reduces the generation possibility of bacterial plaque, from
And the effect of reducing gingivitis, periodontosis illness rate.Strontium salt or sylvite have the effect of anti-sensitivity of tooth.But containing profitable probliotics in potassium
Under salt and/or this high ionization environment of strontium salt, easily there is the bad phenomenon of stability.Thickener is the key in oral cavity composition
It raw material, can make toothpaste that there is appropriate viscosity and denseness, and not feel glutinous greasy, also good mobility, be swelled in toothpaste
In liquid phase, stable colloid is formed, with the toothpaste solid phase that suspends, solid phase components and liquid phase component separation in toothpaste is prevented, is regulation tooth
An important factor for cream stability.
The content of the invention
It is an object of the invention to provide a kind of oral cavity that is used for containing at least one of sylvite and/or strontium salt and probiotics to use
Antibacterial antiallergic perception compositions and toothpaste of product and preparation method thereof.
The present invention realizes that the technical scheme of its purpose is：
A kind of antibacterial antiallergic perception compositions for oral-cavity article, comprising anti-sensitive agent and probiotics, wherein the antiallergic
Sense agent includes at least one of sylvite and/or strontium salt.
Preferably, the probiotics is lactobacillus.
Preferably, the lactobacillus be lactobacillus fermenti, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus rhamnosus,
One or more kinds of mixtures in lactobacillus acidophilus, Lactobacillus casei or secondary cheese lactic acid bacteria.These lactobacillus can be reduced
Or suppress the growth of oral cavity Main Pathogenic Bacteria Streptococcus mutans, streptococcus sobrinus and poly-nuclear Fusobacterium etc., energy antibacterial shield gum, prevent
The symptoms such as halitosis.
Preferably, the percentage by weight of the probiotics is 20~99.9%, and remaining ingredient is sylvite and/or strontium
Salt.The percentage by weight of probiotics is preferably 50~99.9%.
Preferably, the sylvite is selected from potassium nitrate, potassium citrate, potassium chloride, saleratus or potassium oxalate.
Preferably, the strontium salt is selected from strontium chloride, strontium acetate.
Sylvite or strontium salt have anti-sensitivity of tooth effect, and there is probiotics antibacterial to protect gum effect, it has unexpectedly been found that, both are mixed
After conjunction, anti-sensitivity of tooth and antibacterial shield gum effect are obtained for reinforcement, show to act synergistically.
A kind of antibacterial antiallergic perception compositions for being previously described for oral-cavity article toothpaste, liquid tooth paste, mouthwash, tooth powder,
Application in tooth gel or chewing gum.
A kind of antibacterial antiallergic sense toothpaste, comprising NMF, rubbing agent, thickener, surfactant, sweetener, essence and
Water, also include foregoing antibacterial antiallergic perception compositions.
Preferably, described NMF includes one kind or more in glycerine, sorbierite, polyethylene glycol or propane diols
Kind.
Preferably, described thickener, comprising：A) in hydroxyethyl cellulose, xanthans, carragheen or carbomer
It is one or more；B) optional carboxymethyl cellulose.
Preferably, described surfactant includes lauryl sodium sulfate, sodium N-lauroyl sarcosinate, thiosulfonic acid
One or more compositions in sodium or Cocoamidopropyl betaine.
Preferably, in foregoing antibacterial antiallergic sense toothpaste, the percentage by weight of each component is：Probiotics 0.01~
20%, NMF 10~70%, rubbing agent 0~60%, thickener 0.1~10%, surfactant 0.1~20%, sweetener
0.1~2%, essence 0.1~5%, water 0~50%, the sylvite of sylvite 0.01~5% or strontium salt 0.01~3% or 0.01~5%
With the mixing of 0.01~3% strontium salt.
Preferably, in above-mentioned toothpaste, the percentage by weight of described probiotics is 0.01~10%.
A kind of preparation method of antibacterial antiallergic sense toothpaste, comprises the following steps：Add NMF in a reservoir first, then add
Enter thickener quickly to stir, then sequentially add rubbing agent, surfactant, sweetener, sylvite and/or strontium salt, then add
Enter probiotics, and uniform stirring；Then vacuumize, be eventually adding essence, stir homogeneous, degassing, obtain product.
Found in the preparation process of toothpaste, when antibacterial antiallergic perception compositions of the present invention are added in toothpaste system,
Due to salt and the consistency problem of probiotics, toothpaste now may divide water, it is impossible to reach the requirement of toothpaste stability.
It was unexpectedly observed that when in toothpaste thickened systems containing one in hydroxyethyl cellulose, xanthans, carragheen and carbomer
When planting or be a variety of, the lotion stable system containing antibacterial antiallergic perception compositions of the present invention can be made.
The beneficial effects of the invention are as follows：Probiotics can secrete organic acid, a variety of antibacterial materials such as hydrogen peroxide and bacterium,
The ecological balance of oral microorganism is maintained, so as to suppress the growth of germ, has obvious protection gum in the oral cavity, prevent gum
Inflammation, periodontitis, fresh breath, other mouths such as toothpaste, liquid tooth paste, mouthwash, tooth powder, tooth gel, chewing gum can be applied to
In chamber articles for use.Probiotics and sylvite, strontium salt in the antibacterial antiallergic perception compositions of the present invention and the toothpaste with its preparation, to tooth
Sensitivity has the effect of multiple protective, moreover it is possible to some ill symptoms in oral cavity are improved, slow down the hair of periodontosis, gingivitis
It is raw, help user to solve bleeding gums, halitosis, tooth mobility and displacement and prevent the symptoms such as sensitivity of tooth.Applicant is unexpected
Discovery containing one or more in hydroxyethyl cellulose, xanthans, carragheen and carbomer when, it is possible to increase contain this hair
The stability of bright antibacterial antiallergic sense component toothpaste, solve the problems, such as that such a toothpaste stability is poor, it is difficult to preserve.
Embodiment
With reference to embodiment, the invention will be further described, but not thereby limiting the invention.
Experimental method in following embodiments, it is conventional method unless otherwise instructed.
Embodiment 1 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For antibacterial antiallergic perception compositions in oral-cavity article composition, it is made up of the component of following percentage by weight：20~
99.9% probiotics (being preferably 50~99.9%), surplus is sylvite or/and strontium salt, and probiotics is lactobacillus fermenti, plant
One kind in lactobacillus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus acidophilus, Lactobacillus casei or secondary cheese lactic acid bacteria
Or a variety of mixtures, the sylvite are selected from potassium nitrate, potassium citrate, potassium chloride, saleratus or potassium oxalate, the strontium salt choosing
From strontium chloride, strontium acetate, the mixing of sylvite and strontium salt can mix in any proportion.
Embodiment 2 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For the antibacterial antiallergic perception compositions of oral-cavity article, it is made up of the component of following percentage by weight：70% saliva
Lactobacillus, 20% potassium nitrate and 10% strontium chloride.
Embodiment 3 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For the antibacterial antiallergic perception compositions of oral-cavity article, it is made up of the component of following percentage by weight：90% pair is done
Lactobacillus paracasei, 10% potassium oxalate.
Embodiment 4 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For the antibacterial antiallergic perception compositions of oral-cavity article, it is made up of the component of following percentage by weight：50% it is prebiotic
Bacterium, 30% potassium chloride, 20% strontium acetate, probiotics are the mass mixings such as lactobacillus acidophilus and Lactobacillus casei.
Embodiment 5 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For the antibacterial antiallergic perception compositions of oral-cavity article, it is made up of the component of following percentage by weight：20% plant
Lactobacillus, 40% potassium citrate, 40% strontium chloride.
Embodiment 6 is used for the antibacterial antiallergic perception compositions of oral-cavity article
For the antibacterial antiallergic perception compositions of oral-cavity article, it is made up of the component of following percentage by weight：99.9% mouse
Lee's sugar lactobacillus, 0.1% strontium acetate.
The antibacterial antiallergic sense toothpaste of embodiment 7 and preparation method
Antibacterial antiallergic sense toothpaste, by foregoing antibacterial antiallergic perception compositions, NMF, rubbing agent, thickener, surface-active
Agent, sweetener, essence and water composition.The percentage by weight of each component is：
Probiotics 0.01~20%, preferably 0.01~10%, the probiotics be lactobacillus fermenti, Lactobacillus plantarum,
One or more in Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus acidophilus, Lactobacillus casei or secondary cheese lactic acid bacteria
Mixture.
NMF 10~70%, preferably 20~40%, glycerine, sorbierite, polyethylene glycol or propane diols etc. can be used
Single or its mixture.
Rubbing agent 0~60%, preferably 20~50%；Calcium carbonate, hydrated SiO 2, calcium monohydrogen phosphate, Jiao can be used
Calcium phosphate etc..
Thickener 0.1%~10%, preferably 0.5~2%；Can use hydroxyethyl cellulose, sodium carboxymethylcellulose,
Carragheen, xanthans, Sodium Polyacrylate, carbomer etc. be single or its mixture.
Surfactant 0.1~20%, preferably 0.1~3%；Anion, cation, both sexes and nonionic can be used
Surfactant etc. is single or its mixture, such as lauryl sodium sulfate, sodium N-lauroyl sarcosinate, sulphonic acid sodium or cocounut oil
Amido propyl betaine.
Sweetener 0.1%~2%, preferably 0.1~0.5%；Saccharin sodium, Sucralose etc. can be used.
Essence 0.1~5%, preferably 0.1~1.5%；Peppermint, spearmint oil can be used, American mint, brain can be thought
Deng.
The mixing of the sylvite and 0.01~3% strontium salt of sylvite 0.01~5% or strontium salt 0.01~3% or 0.01~5%.
Water 0~50%, preferably 15~30%, using pure water.
The preparation method of the toothpaste is：Add NMF in a reservoir first, add thickener and quickly stir,
Then rubbing agent, surfactant, sweetener, sylvite or/and strontium salt are sequentially added, adds probiotics, and uniform stirring；So
After vacuumize, be eventually adding essence, stir homogeneous, degassing, obtain product.
The antibacterial antiallergic sense toothpaste of embodiment 8
8 kinds of antibacterial antiallergic sense toothpaste are prepared according to the formula in embodiment 7 and method, its specific formula is shown in Table 1.
The antibacterial antiallergic sense formulation of tooth-paste of 18 kinds of table
Embodiment 9
Toothpaste is prepared according to the formula and method of embodiment 7, production technology is：NMF is first added in Manufacturing medicine extract machine, such as
Sorbierite or glycerine etc., add thickener hydroxyethyl cellulose and quickly stir, sequentially add saccharin sodium, potassium nitrate, chlorine
Change the small powder such as strontium and probiotics and stir, add abrasive silica, stir homogeneous, then vacuumize stirring, be eventually adding
Essence, homogeneous is stirred, degassing, lotion is made.
In order to verify the shield gum antiallergic effect of toothpaste of the present invention, it is prepared for being not added with the tooth that antiallergy component only adds probiotics
Cream (2 groups in table 2), and add the toothpaste (4 groups in table 2) of probiotics and antiallergy component, and the control of two kinds of toothpaste
(1 group in table 2 and 3 groups), specific formula is shown in Table 2.
The embodiment formulation of tooth-paste table of table 2
Clinical trial is carried out to four groups of toothpaste shown in table 2, the 3rd group carries out treatment ratio for 151 sensitive teeths
Compared with test result is shown in Table 3.
The hypersensitive dentin test result of table 3
There are dental hypersensitivity, gingivitis, periodontal disease patient to carry out examination brush for four groups of toothpaste above, selection respectively,
Test result table 4.
4 four groups of test specimens of table have the test result of the patient of odontitis disease through examination brush test
Learnt from upper table 3,3 groups of sample tests, 151 cacodontias, 78.8% cure rate has been obtained after experiment, has illustrated potassium
Salt, strontium salt are a kind of extraordinary desensitizer to hemodia.In terms of the result of the test tested from table 4,1 group is that blank control is tested,
After the consumer of same patient number tries brush, the improvement rate of several symptoms of this in hemodia, gingivitis, patients with periodontitis is all very
It is low.Compared to 2 groups, add the toothpaste of probiotics, in the healing of dental hypersensitivity, have in 33 people 20 people be it is invalid, can be to gum
Inflammation, the experiment of periodontitis, it is found that the experimenter to take a turn for the better accounts for 27/33 and 29/33 respectively.Sylvite, strontium salt desensitization are added in 3 groups of samples
Agent, the improvement rate of opposed teeth allergy, periodontitis and gingivitis improvement rate ratio are relatively low.4 groups, relative to above blank group, only add benefit
Raw bacterium group, only add for desensitizer group, the improvement rate of the improvement rate of dental hypersensitivity, gingivitis and periodontitis is all significantly larger than
Control group, also above probiotic group is individually added into, higher than the improvement rate for being individually added into desensitizer group.Above clinical test can illustrate,
Relative to the combination for being individually added into probiotics or desensitizer, the combination of probiotics and desensitizer strengthens toothpaste desensitization effect, improved
To gingivitis, the improvement rate of periodontitis, illustrate that probiotics has synergy with desensitizer, effect is applied in combination better than independent in it
Using effect；Additive provided by the invention has preferable effect to improving the oral conditions such as hemodia, gingivitis, periodontitis.
The antibacterial antiallergic composition of the present invention is not limited solely in a kind of toothpaste this oral-cavity article, in liquid tooth paste, is gargled
It is equally applicable in other oral-cavity articles such as water, tooth powder, tooth gel, chewing gum.
The toothpaste stability experiment of embodiment 10
6 groups of toothpaste are prepared according to the inventive method, the specific formula ratio of each group toothpaste is shown in Table 5.
Table 5 is used for the different formulation of tooth-paste of performance test
For the toothpaste stablized, the present embodiment employs different formulation of tooth-paste and tested, and devises 6 groups of examinations altogether
Test, as shown in table 5, it is seen then that 1 group of toothpaste, which can not be stablized, to be preserved, and after placing certain time, a point water, anti-thick etc. can all occurs no
Good phenomenon, commodity property is poor, have a strong impact on toothpaste quality, can not be in market sale.Sodium carboxymethylcellulose is only added in 1 group,
Water-separation is more serious；Xanthans is added in 2 groups, toothpaste stability is preferable, water-separation does not occur；Added in 3 groups
There are xanthans and carragheen, toothpaste stability is good, and lotion is fine and smooth；Carbomer and sodium carboxymethylcellulose, lotion are added in 4 groups
Can be stable；Sodium hydroxyethlcellulose is added with 5 groups, toothpaste is stabilized；Carragheen is added with 6 groups, toothpaste is stabilized.
Claims (5)
1. a kind of antibacterial antiallergic sense toothpaste, it is characterised in that the percentage by weight of each component is：Probiotics 0.01~20%, protect
Humectant 10~70%, rubbing agent 0~60%, thickener 0.1~10%, surfactant 0.1~20%, sweetener 0.1~
2%, essence 0.1~5%, the sylvite and 0.01~3% strontium salt of water 0~50%, 0.01~5%；Described probiotics is hair
Kefir milk bacillus, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus acidophilus, Lactobacillus casei or secondary cheese breast
One or more kinds of mixtures in sour bacterium；Described thickener includes：A) hydroxyethyl cellulose, xanthans, carragheen or card
One or more in ripple nurse, b) optional sodium carboxymethylcellulose.
2. antibacterial antiallergic sense toothpaste as claimed in claim 1, it is characterised in that the sylvite be selected from potassium nitrate, potassium citrate,
Potassium chloride, saleratus or potassium oxalate, the strontium salt are selected from strontium chloride, strontium acetate.
3. antibacterial antiallergic sense toothpaste as claimed in claim 1, it is characterised in that the NMF includes glycerine, sorbierite, gathered
One or more in ethylene glycol or propane diols.
4. antibacterial antiallergic sense toothpaste as claimed in claim 1, it is characterised in that the surfactant includes dodecyl sulphur
One or more compositions in sour sodium, sodium N-lauroyl sarcosinate, sulphonic acid sodium or Cocoamidopropyl betaine.
5. the preparation method of the antibacterial antiallergic sense toothpaste as described in claim any one of 1-4, it is characterised in that first in container
Middle addition NMF, adds thickener and quickly stirs, and then sequentially adds rubbing agent, surfactant, sweetener, potassium
Salt and strontium salt, add probiotics, and uniform stirring；Then vacuumize, be eventually adding essence, stir homogeneous, degassing, produced
Product.
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| RU2011100746A (en) * | 2008-06-24 | 2012-07-27 | Вм. Ригли Дж. Компани (Us) | COMPOSITION OF CHEWING RUBBER WITH PROBIOTIC AND METHOD OF ITS PRODUCTION |
| EP2455095B1 (en) * | 2009-07-16 | 2017-06-07 | Hiroshima University | Prophylactic, ameliorating or therapeutic agent for oral diseases |
| CN102895147B (en) * | 2012-09-25 | 2015-04-29 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
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| CN109925335A (en) * | 2019-04-11 | 2019-06-25 | 上海华芝堂科技发展有限公司 | The composition of prevention carcinoma of mouth for oral-cavity article |
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