CN106265470A - Probiotics fermention compound recipe herbaceous toothpaste - Google Patents
Probiotics fermention compound recipe herbaceous toothpaste Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
A kind of probiotics fermention compound recipe herbaceous toothpaste is provided, including toothpaste base material, also include fermentation of Chinese herbal medicine and inactivated probiotic, wherein said toothpaste base material weight portion is 97 parts, fermentation of Chinese herbal medicine weight portion is 0.5 1 parts, inactivated probiotic weight portion is 12 parts, described fermentation of Chinese herbal medicine is by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan are made with probiotic mixed fermentation, wherein said Flos Lonicerae weight portion is 0.3～0.5 part, Radix Scutellariae weight portion is 0.6～0.8 part, Fructus Forsythiae weight portion is 0.2～0.3 part, Fructus Ligustri Lucidi weight portion is 0.2～0.3 part, Cortex Moutan weight portion is 0.3～0.5 part.The Chinese herbal medicine of the present invention after probiotics fermention, more compounding with inactivated probiotic after make, there is balance oral cavity flora, dispel halitosis, antiinflammatory, the function of healthy periodontal.
Description
Technical field
The invention belongs to formulation of tooth-paste technical field, be specifically related to a kind of probiotics fermention compound recipe herbaceous toothpaste.
Background technology
Human Oral Cavity common disease has oral ulcer, periodontal disease, dental pulp disease, halitosis, dental caries, oral candidiasis
It is to be made by the gram-negative anaerobic bacteria of typically living away from home of speckle under the gum being positioned under gum in capsule Deng, the main cause one of these commonly encountered diseases
Becoming, two is that oral cavity Hypersensitivity Syndrome causes.Bad oral health can be associated with other pathology, such as gastric ulcer, gastric cancer
Or cardiovascular disease etc..Toothpaste is cleaning supplies required in daily life, has the good action in cleaning oral cavity, and can protect
Protecting tooth and do not damage enamel and dentin, existing toothpaste is of a great variety, although have a various Chinese herbal toothpaste, but because of
Macromolecular substances unconverted in Chinese herbal medicine and make to be that its effect is unsatisfactory；Oral health behaviours system can not be in the most flat
Weigh and cause various oral disease；Contained preservative is chemical preservative, and life-time service has accumulation, can produce human liver
Harm, the most carcinogenic.So a lot of herbaceous toothpastes are in use for some time, its effect can decline to a great extent, and the most how to overcome
The deficiencies in the prior art have become the technical barrier that existing field is urgently to be resolved hurrily.
Summary of the invention
Present invention solves the technical problem that: providing a kind of probiotics fermention compound recipe herbaceous toothpaste, Chinese herbal medicine is sent out through probiotic bacteria
After ferment, more compounding with inactivated probiotic after make, there is balance oral cavity flora, dispel halitosis, antiinflammatory, the merit of healthy periodontal
Energy.
The technical solution used in the present invention: probiotics fermention compound recipe herbaceous toothpaste, including toothpaste base material, also includes in fermentation
Medical herbs and inactivated probiotic, wherein said toothpaste base material weight portion is 97 parts, and fermentation of Chinese herbal medicine weight portion is 0.5-1 part, inactivation
Probiotic bacteria weight portion is 1-2 part, and described fermentation of Chinese herbal medicine is mixed with probiotic bacteria by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan
Fermentation is made, and wherein said Flos Lonicerae weight portion is 0.3～0.5 part, and Radix Scutellariae weight portion is 0.6～0.8 part, and Fructus Forsythiae weight portion is
0.2～0.3 part, Fructus Ligustri Lucidi weight portion is 0.2～0.3 part, and Cortex Moutan weight portion is 0.3～0.5 part.
Wherein, described inactivated probiotic is the Lactobacillus paracasei (CGMCC1.2468) with inactivation and Lactobacillus salivarius
(CGMCC1.1881) in the composite bacteria of 4:6 ratio composition；Said herbal medicine and probiotic bacteria are in the ratio mixed fermentation system of 93:7
Becoming, described probiotic bacteria is that Lactobacillus paracasei (CGMCC1.2468) and Lactobacillus salivarius (CGMCC1.1881) are mixed in 2:1 ratio
Conjunction is made.
Wherein, after described fermentation of Chinese herbal medicine is by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan and probiotic mixed fermentation
Juice after micronizing or filter pressing is made.
Further, described toothpaste base material includes wetting agent 15～25 parts, adhesive 1～1.5 parts, abrasive 45～55
Part, washing foaming agent 1.5～3 parts, flavouring agent 0.8～1.4 parts, sweeting agent 0.1～0.3 part, buffer agent 0.3～0.6 part, anticorrosion
Agent 0.05～0.3 part.
Further, the wetting agent that described toothpaste base material comprises 10 parts, adhesive 1 part, abrasive 50 parts, washing foaming agent
3 parts, flavouring agent 1 part, sweeting agent 0.2 part, buffer agent 0.45 part, preservative 0.2 part.
Further, described wetting agent is glycerol, and described adhesive is xanthan gum, and described abrasive is calcium carbonate, dioxy
SiClx and calcium hydrogen phosphate are formed in 5:2:3 ratio, and described washing foaming agent is dodecylbenzene sodium sulfonate, and described flavouring agent is for staying
Blue Oleum sesami, Fructus Citri Limoniae oil, citrus oils are formed in 1:1:1 ratio, and described sweeting agent is saccharin sodium, and described buffer agent is sodium pyrophosphate,
Described preservative is nisin.
The present invention is compared with prior art
1, Lactobacillus salivarius (CGMCC1.1881) separation source selected in the present invention is from the saliva of people, is the micro-life in oral cavity
Primary strain in system system, will not antagonism, repellency competition, and the Th1 type that can regulate in allergic immune response can be excited
Immunoreation balances the Th2 type immunoreation that allergy is caused, and promotes tooth, the antianaphylactic ability of gingiva, pre-hypo-allergenic instead
Recurrence is made, and the most also can reach the effect improving allergic constitution.
2, general toothpaste selects sodium benzoate as preservative, and sodium benzoate is a kind of chemical preservative, and life-time service has
Accumulation property, can produce harm to human liver, the most carcinogenic.The present invention select nisin, nisin be by
The polypeptide compounds of several amino acids composition, can be absorbed by the body as nutrient substance and utilize the color to food, mouth
Sense etc. has no adverse effects, even if quickly hydrolyzing under the physiological pH condition and alpha-chymotrypsin effect of human body after eating on a small quantity
Become aminoacid, normal flora will not be changed in human body intestinal canal and produce the resistance problem occurred such as other antibiotics, less
Can and other antibiotics cross tolerance occurs, efficient, nontoxic, safely, have no side effect.
3, toothpaste can not keep the long time i.e. to be gargled in mouth, and common drug toothpaste is difficult to play at short notice medicine
Effect；And special medicament dosage must also be avoided stimulating soft tissue in mouth, thus enough valid density can not be brought up to, commonly
Chinese herbal medicine is often hindered by dirt in mouth or is limited by morphological characteristic, thus is difficult to the region reaching really to fall ill；In additionally common
Medical herbs how many most toxic compositions, life-time service can produce harmful effect to health.Present invention probiotic bacteria is by Chinese herbal medicine
Macromolecular substances transforms into the little molecular chaperones that directly can be absorbed by oral cavity, make Chinese medicine ingredients quickly absorb, curative effect speed-raising；
Sweat decomposes toxicity, really has no side effect；Dispel halitosis, nutrition gingiva, healthy periodontal.
Detailed description of the invention
Embodiments of the invention are described below.
Embodiment one: probiotics fermention compound recipe herbaceous toothpaste, takes toothpaste base material 97.0kg, fermentation of Chinese herbal medicine 2.0kg, inactivation
Probiotic bacteria 1.0kg.Fermentation of Chinese herbal medicine wherein Flos Lonicerae is 0.3kg, Radix Scutellariae 0.6kg, Fructus Forsythiae 0.2kg, Fructus Ligustri Lucidi 0.2kg, Cortex Moutan
0.3kg and probiotic bacteria (Lactobacillus paracasei CGMCC1.2468 and Lactobacillus salivarius CGMCC1.1881 is in 2:1 ratio) press 93:7
Ratio mixed fermentation make, specifically, fermentation of Chinese herbal medicine is mixed with probiotic bacteria by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan
After closing fermentation, the juice after micronizing or filter pressing is made；Inactivated probiotic is the Lactobacillus paracasei with inactivation
And the composite bacteria that forms in 4:6 ratio of Lactobacillus salivarius (CGMCC1.1881) (CGMCC1.2468)；Toothpaste base material includes sweet
Oil 15kg, xanthan gum 1kg, abrasive (forming in 5:2:3 ratio for calcium carbonate, silicon dioxide and calcium hydrogen phosphate) 45kg, 12
Sodium alkyl benzene sulfonate 1.5kg, flavouring agent (forming in 1:1:1 ratio for Oleum Menthae Rotundifoliae, Fructus Citri Limoniae oil, citrus oils) 0.8kg, saccharin sodium
0.1kg, sodium pyrophosphate 0.3kg, nisin 0.05kg.
Embodiment two: probiotics fermention compound recipe herbaceous toothpaste, takes toothpaste base material 97.0kg, fermentation of Chinese herbal medicine 1.0kg, inactivation
Probiotic bacteria 2kg.Fermentation of Chinese herbal medicine wherein Flos Lonicerae is 0.5kg, Radix Scutellariae 0.8kg, Fructus Forsythiae 0.3kg, Fructus Ligustri Lucidi 0.3kg, Cortex Moutan
0.5kg and probiotic bacteria (Lactobacillus paracasei CGMCC1.2468 and Lactobacillus salivarius CGMCC1.1881 is in 2:1 ratio) press 93:7
Ratio mixed fermentation make, specifically, fermentation of Chinese herbal medicine is mixed with probiotic bacteria by Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan
After closing fermentation, the juice after micronizing or filter pressing is made；Inactivated probiotic is the secondary cheese milk bar with inactivation
And the composite bacteria that forms in 4:6 ratio of Lactobacillus salivarius (CGMCC1.1881) (CGMCC1.2468)；Toothpaste base material includes sweet
Oil 25kg, xanthan gum 1.5kg, abrasive (forming in 5:2:3 ratio for calcium carbonate, silicon dioxide and calcium hydrogen phosphate) 55kg, ten
Dialkyl benzene sulfonic acids sodium 3kg, flavouring agent (forming in 1:1:1 ratio for Oleum Menthae Rotundifoliae, Fructus Citri Limoniae oil, citrus oils) 1.4kg, saccharin sodium
0.3kg, sodium pyrophosphate 0.6kg, preservative is nisin 0.03kg.
The compound inactivated probiotic contained in the technical program forms dominant microflora in oral cavity, suppression harmful bacterial growth and
Propagation, keeps oral cavity flora balance；Lactobacillus salivarius therein (CGMCC1.1881) separation source, from the saliva of people, is oral cavity
Primary strain in microflora, can excite the Th1 type immunoreation that can regulate in allergic immune response to balance allergy
The Th2 type immunoreation caused, promotes tooth, the antianaphylactic ability of gingiva, pre-hypo-allergenic recurrent exerbation, the most also can reach
Improve the effect of allergic constitution.
In the technical program, Chinese herbal medicine many compositions are effectively degraded through probiotic bacteria, are turned by inactive precursor substance after metabolism
Turn to tool prevention, the effective ingredient of therapeutical effect, strengthen drug effect, reduce toxic component, alleviate the damage to body, finally suppress
Remove pathogenic microorganism, the antiinflammatory that reaches to relieve inflammation or internal heat, dispel halitosis, nutrition gingiva, the health care purpose of healthy periodontal.
Flos Lonicerae in the technical program, Fructus Forsythiae have antiviral, antibacterial, relieve inflammation or internal heat, antiinflammation；Radix Scutellariae tool spleen invigorating circulation of qi promoting it
Effect；Fructus Ligustri Lucidi, Cortex Moutan tool QI invigorating, the immunity that improves, the effect of enhancing resistance against diseases.
Preparation method:
The first step: Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan are uniformly mixed according to a ratio, cleans, dries, with special
Equipment micronizing, fermentation after standby；
Second step: prepared by inactivation strain, fits the modes such as pressure inactivate Lactobacillus paracasei and saliva with ultraviolet irradiation, thermophilic
Lactobacillus.
3rd step: the component premixing that sweeting agent, buffer agent, preservative equivalent are few is homogeneously disposed in first barrel stand-by；Profit
Humectant, adhesive premixing are homogeneously disposed in second barrel stand-by；
4th step: abrasive, washing foaming agent add deionization with the Chinese herbal medicine fermented, flavouring agent, inactivated probiotic
Water, and add stand-by material cream the most processed in first and second barrel, mastic grinds stirring 1 hour, goes out cream, form.
Using above-mentioned toothpaste, first store 3 months, treatment oral cavity disease made by the attached stomatological hospital of Zai Songzhu The Fourth Military Medical University
Sick observation of curative effect.
Clinical observation, treats 300 examples such as toothache, gingivitis, oral ulcer, is now summarized as follows:
Clinical data: the object of observation is this Out-patient Department and inpatient, totally 300 example, wherein male 167 example, and women 133
Example, the oldest person 70 years old, reckling 16 years old, patient is respectively with toothache, gingival hemorrhage, odontoseisis, oral ulcer, halitosis etc.
Main suit goes to a doctor, all cases through clinical diagnosis, be divided into light, in, weigh three types, 70 examples of having a toothache, gingivitis 80 example, periodontitis 50 example,
Oral ulcer 100 example, each classification of cases sees attached list.
Therapeutic Method: toothache: cleaning suffers from tooth, puts appropriate toothpaste in affected part, and advises and brush teeth with toothpaste, the most each 3 minutes, and 7
Further consultation after it.The diseases such as gingivitis, periodontitis, oral ulcer, with toothpaste early, evening respectively brush teeth 3 minutes, note avoiding intensive property to stimulate
Food, further consultation after 10 days.
Criterion of therapeutical effect
Patient, after 7-30 days treat in order to top method, carries out curative effect statistics, and criterion of therapeutical effect is as follows: cure:
Disappearing with sings and symptoms after toothpaste, normal occlusion, without uncomfortable；
Effective: with cardinal symptom after toothpaste and Signs substantially alleviate, slightly uncomfortable；
Take a turn for the better: alleviate by cardinal symptom after toothpaste and Signs, transference cure after treating with other medicines；
Invalid: by cardinal symptom after toothpaste and Signs without improving, even to increase the weight of.
Therapeutic outcome: see attached list
Above-described embodiment, simply presently preferred embodiments of the present invention, not be used for limiting the scope of the present invention, therefore all with this
The equivalence change that content described in invention claim is done, within all should being included in scope of the invention as claimed.
Claims (6)
1. probiotics fermention compound recipe herbaceous toothpaste, including toothpaste base material, it is characterised in that: also include fermentation of Chinese herbal medicine and inactivation benefit
Raw bacterium, wherein said toothpaste base material weight portion is 97 parts, and fermentation of Chinese herbal medicine weight portion is 0.5-1 part, inactivated probiotic weight portion
For 1-2 part, described fermentation of Chinese herbal medicine is made up with probiotic mixed fermentation of Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan, its
Described in Flos Lonicerae weight portion be 0.3～0.5 part, Radix Scutellariae weight portion is 0.6～0.8 part, and Fructus Forsythiae weight portion is 0.2～0.3 part,
Fructus Ligustri Lucidi weight portion is 0.2～0.3 part, and Cortex Moutan weight portion is 0.3～0.5 part.
Probiotics fermention compound recipe herbaceous toothpaste the most according to claim 1, it is characterised in that: described inactivated probiotic is for using
The compound bacteria that the Lactobacillus paracasei (CGMCC1.2468) of inactivation and Lactobacillus salivarius (CGMCC1.1881) are formed in 4:6 ratio
Kind；Said herbal medicine is made in the ratio mixed fermentation of 93:7 with probiotic bacteria, and described probiotic bacteria is Lactobacillus paracasei
(CGMCC1.2468) it is mixed in 2:1 ratio with Lactobacillus salivarius (CGMCC1.1881).
Probiotics fermention compound recipe herbaceous toothpaste the most according to claim 1 and 2, it is characterised in that: described fermentation of Chinese herbal medicine
It is made up of micronizing after Flos Lonicerae, Radix Scutellariae, Fructus Forsythiae, Fructus Ligustri Lucidi and Cortex Moutan and probiotic mixed fermentation or the juice after filter pressing.
Probiotics fermention compound recipe herbaceous toothpaste the most according to claim 1 and 2, it is characterised in that: described toothpaste base material bag
Include wetting agent 15～25 parts, adhesive 1～1.5 parts, abrasive 45～55 parts, washing foaming agent 1.5～3 parts, flavouring agent 0.8～
1.4 parts, sweeting agent 0.1～0.3 part, buffer agent 0.3～0.6 part, preservative 0.05～0.3 part.
Probiotics fermention compound recipe herbaceous toothpaste the most according to claim 4, it is characterised in that: described toothpaste base material comprises
Wetting agent 10 parts, adhesive 1 part, abrasive 50 parts, washing foaming agent 3 parts, flavouring agent 1 part, sweeting agent 0.2 part, buffer agent
0.45 part, preservative 0.2 part.
Probiotics fermention compound recipe herbaceous toothpaste the most according to claim 5, it is characterised in that: described wetting agent is glycerol,
Described adhesive is xanthan gum, and described abrasive is that calcium carbonate, silicon dioxide and calcium hydrogen phosphate are formed in 5:2:3 ratio, described
Washing foaming agent is dodecylbenzene sodium sulfonate, and described flavouring agent is that Oleum Menthae Rotundifoliae, Fructus Citri Limoniae oil, citrus oils are in 1:1:1 ratio group
Becoming, described sweeting agent is saccharin sodium, and described buffer agent is sodium pyrophosphate, and described preservative is nisin.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727268A (en) * | 2017-02-22 | 2017-05-31 | 云南白药集团股份有限公司 | Oral disnitegration tablet and preparation method thereof |
| CN109330942A (en) * | 2018-11-22 | 2019-02-15 | 林锡慧 | A kind of formulation of tooth-paste containing oral cavity probiotics |
| CN109528625A (en) * | 2019-01-18 | 2019-03-29 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing probiotics and antibacterial peptide |
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| CN106727268A (en) * | 2017-02-22 | 2017-05-31 | 云南白药集团股份有限公司 | Oral disnitegration tablet and preparation method thereof |
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| CN109528625A (en) * | 2019-01-18 | 2019-03-29 | 扬州倍加洁日化有限公司 | Oral cavity composition and its application containing probiotics and antibacterial peptide |
| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| CN113813341A (en) * | 2021-11-23 | 2021-12-21 | 广东益可维生物技术有限公司 | Traditional Chinese medicine probiotic fermented extract for improving oral problems, preparation method and application |
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