CN108014053A - A kind of Chinese medicine herbaceous toothpaste - Google Patents
A kind of Chinese medicine herbaceous toothpaste Download PDFInfo
- Publication number
- CN108014053A CN108014053A CN201810101067.2A CN201810101067A CN108014053A CN 108014053 A CN108014053 A CN 108014053A CN 201810101067 A CN201810101067 A CN 201810101067A CN 108014053 A CN108014053 A CN 108014053A
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- CN
- China
- Prior art keywords
- extract
- toothpaste
- additive amount
- chinese medicine
- multiflower knotweed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of toothpaste containing Chinese medical extract combination.The Chinese medical extract combination composition be：Polygonum multiflower knotweed extract, Herba Blumeae Balsamiferae extract, Flos Caryophylli extract, Heavenly Teacher's chestnut extract, wherein, the additive amount of the Polygonum multiflower knotweed extract is 1% 10%；The additive amount of Herba Blumeae Balsamiferae extract is 0.05 1.5% (in terms of content of bornyl alcohol)；The additive amount of Flos Caryophylli extract is 0.5% 5.0%；The additive amount of Heavenly Teacher's chestnut extract is 0.1 2.5% (with otoginsenoside content meter).Weight accounting content of the 4 kinds of Chinese medical extracts in toothpaste is 2 19%；Toothpaste containing the traditional Chinese medicine ingredients not only has antibacterial, fresh breath, improves oral peculiar smell, and has improvement sleep effect.
Description
Technical field
Present invention relates particularly to one kind by Polygonum multiflower knotweed, Blumea balsamifera, cloves, Aesculus wilonii extract and toothpaste matrix mixed preparing
The Chinese medicinal toothpaste formed, is a kind of containing traditional Chinese medicine ingredients, has antibacterial, fresh breath, improves oral peculiar smell, while also have
Improve the toothpaste of sleep effect.
Technical background
Toothpaste is almost the requirement of everyone daily life, and most people have the custom brushed teeth in early, evening, present market
On toothpaste based on whitening, anti-inflammatory, antibacterial.With the development of society, social rhythm accelerates, operating pressure increase, easily
People are caused to have a sleepless night, according to statistics, the insomnia rate of Chinese adult is up to 38%.For case above, have devised with traditional Chinese medicine extraction
Thing is the toothpaste of main Effect raw material, not only with antibacterial, fresh breath, improvement oral peculiar smell, while there is improvement sleep to make
With；People can be brushed teeth by morning, evening, can make medicine by buccal absorption, in the case where that need not change habits and customs, just
Fresh breath can be obtained and improve the effect of sleep.
The content of the invention
It is a kind of using Chinese medical extract for primary efficacy original it is an object of the invention to provide a kind of different from passing technology
The toothpaste of material, unlike ordinary toothpaste, the toothpaste not only have antibacterial, anti-inflammatory, and can fresh breath, improve oral cavity it is different
Taste, while sleep can also be improved.
The present invention is achieved through the following technical solutions：
A kind of Chinese medicinal toothpaste, by the material composition of following percetage by weight：
Chinese medical extract total amount 2-19%, surplus are toothpaste matrix；
In above-mentioned toothpaste, the Chinese medical extract is extracted by Polygonum multiflower knotweed extract, Herba Blumeae Balsamiferae extract, cloves
Thing, Heavenly Teacher's chestnut extract composition, the additive amount of extract are：Polygonum multiflower knotweed extract 1-10%, Herba Blumeae Balsamiferae extract (are contained with borneol
Gauge) 0.05-1.5%, Flos Caryophylli extract 0.5-5%, Heavenly Teacher's chestnut extract (with otoginsenoside content meter) 0.1-2.5%.
The toothpaste matrix is rubbing agent, wetting agent, thickener, surfactant, preservative, sweetener and water；
The rubbing agent is one or both of calcium carbonate, calcium monohydrogen phosphate, silica, calcium pyrophosphate, aluminium hydroxide
Thing mixed above；
The wetting agent is one or both of glycerine, polyethylene glycol, sorbierite thing mixed above；
The thickener is one or both of sodium carboxymethylcellulose, xanthans, sodium alginate thing mixed above；
The surfactant is one or both of sldium lauryl sulfate, lauryl sodium sulfate mixture；
The preservative is one or both of sodium benzoate, potassium sorbate mixture；
The sweetener is xylitol；
Compared with the prior art, present invention firstly provides, there is antibacterial, anti-inflammatory, and can fresh breath, improvement oral cavity
Peculiar smell, while also there is the toothpaste of sleeping；Polygonum multiflower knotweed in toothpaste, in the work described in Chinese Pharmacopoeia with nourishing blood and tranquilization
With for insomnia and dreamful sleep；Blumea balsamifera has the function that inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain, while also has unique aromatic odor, can
Fresh breath, improves oral peculiar smell；Cloves can alleviate abdominal bloating, increase gastric secretion, strengthen digestion power, mitigate nausea and vomit
Spit, while have inhibitory action to staphylococcus, streptococcus, Escherichia coli, typhoid bacillus, Pseudomonas aeruginosa；Aesculus has soothing the liver
Qi-regulating, and the effect of stomach and alleviating pain；Combined, acted synergistically by above component, make the toothpaste that there is antibacterial, anti-inflammatory, and can pure and fresh mouth
Gas, improve oral peculiar smell, while can also improve the effect of sleep.
Specific implementation method
The preparation method of toothpaste is：
Each Chinese medicine dry product of each embodiment is crushed respectively, respectively with 50-70% ethanol waters, when dipping 24 is small, is oozed
Filter extraction, recycling ethanol is simultaneously concentrated into density 1.2-1.3g/cm3(50 DEG C of surveys) is up to Chinese medical extract；By the base needed for toothpaste
Matter, mixes according to a conventional method, adds Chinese medical extract, dispersed, then the water of polishing surplus, after stirring evenly, presses
Conventional method is filling, and room temperature preserves.Embodiment 1-3 is as shown in table 1：
Table 1：Specific embodiment 1-3
Effete test embodiment
There is antibacterial, fresh breath for the present invention individually below, improve oral peculiar smell, and have the Chinese medicine for improving sleep effect
The extracorporeal bacteria inhibitor test of toothpaste and clinical sleeping are tested.
1st, extracorporeal bacteria inhibitor test
1) test method：Streptococcus mutans, Candida albicans, Prevotella intermedia, porphyromonas gingivalis are chosen as body
Outer experiment microorganism.Aseptically operate, take the slant culture of each bacterial strain, it is special to sterilized 100ml to select a ring
Liquid is determined, when activation culture 24 is small in culture medium.The bacteria suspension 1ml after activation is taken into sterilized culture dish, using pouring into
Flat band method is down flat plate, shakes up.Sterilized Oxford cup is equably placed in culture dish with tweezers after culture medium solidification, each
Culture dish puts 3.By toothpaste and water by 1: 1 dilution, taken in 0.25ml toothpaste dilution injection Oxford cup, separately taken pair with liquid-transfering gun
Physiological saline is added according to group.By culture dish be put into 37 DEG C of incubators culture 24 it is small when, vernier caliper measurement inhibition zone is used in taking-up
Diameter.
2) result of the test：It is shown in Table 2
The extracorporeal bacteria inhibitor test result of 2 embodiment 1-3 of table
The Chinese medicinal toothpaste of the present invention is can be seen that to variation hammer common in oral cavity from 2 extracorporeal bacteria inhibitor test result of table
Bacterium, Candida albicans, Prevotella intermedia, porphyromonas gingivalis are inhibited.Toothpaste prepared by the present invention can effectively press down
Donsole chamber bacteria breed.
2nd, sleep eficac Clinical experiment is improved
1) test method：It is random to certain school using sleep state Self-assessment Scale (SRSS) totally 10 entries of Li Jianming
Selection have certain sleep-disorder, the student 200 of voluntary acceptance test is tested, and is divided equally into 4 groups, respectively using embodiment 1,
2nd, 3 toothpaste, control group are compared using ordinary toothpaste, it is desirable to which subject is early daily, evening respectively brushes a tooth, at least brushes 1 every time
Minute；Before using product, and using product after 1 week, tested respectively with sleep state Self-assessment Scale (SRSS), it is right before and after progress
Than, according to sleep state Self-assessment Scale (SRSS) score, judging the effect of product, score >=23 point are sleep state exception person,
23-29 points are hypophypnosis problem, and 30-39 points are moderate sleeping problems, and 45-50 points are severe sleeping problems.Use SPSS
16.0 softwares carry out statistical analysis, and measurement data is usedRepresent, it is as a result as follows.
2) result of the test：It is shown in Table 3
Table 3：The sleeper effect result of the test of embodiment 1-3
Embodiment 1,2,3 is can be seen that from the experimental result of table 3, using front and rear contrast in 1 week, SRSS score values reduced,
Differentiation has statistical significance (P ＜ 0.05), and control group illustrates that toothpaste of the invention has sleeping work(then without significant difference
Effect.
The above, is only presently preferred embodiments of the present invention, not makees limitation in any form to invention.
Claims (1)
1. a kind of Chinese medicine herbaceous toothpaste, it is characterised in that the traditional Chinese medicine extraction material of following percetage by weight is added in toothpaste matrix
Composition：The additive amount of Polygonum multiflower knotweed extract is 1%-10%；The additive amount of Herba Blumeae Balsamiferae extract is the 0.05- (in terms of content of bornyl alcohol)
1.5%；The additive amount of Flos Caryophylli extract is 0.5%-5.0%；The additive amount of Heavenly Teacher's chestnut extract is (with otoginsenoside content
Meter) 0.1-2.5%, surplus is auxiliary agent；
The Polygonum multiflower knotweed extract is Polygonum multiflower knotweed extracting solution；
The Herba Blumeae Balsamiferae extract is Blumea balsamifera extracting solution, its characteristic component is borneol；
The Flos Caryophylli extract is cloves extracting solution；
Heavenly Teacher's chestnut extract is Aesculus extracting solution, its characteristic component is otoginsenoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810101067.2A CN108014053A (en) | 2018-02-01 | 2018-02-01 | A kind of Chinese medicine herbaceous toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810101067.2A CN108014053A (en) | 2018-02-01 | 2018-02-01 | A kind of Chinese medicine herbaceous toothpaste |
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| Publication Number | Publication Date |
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| CN108014053A true CN108014053A (en) | 2018-05-11 |
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ID=62074991
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810101067.2A Pending CN108014053A (en) | 2018-02-01 | 2018-02-01 | A kind of Chinese medicine herbaceous toothpaste |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159365A (en) * | 2021-12-24 | 2022-03-11 | 武汉爱民制药股份有限公司 | Antibacterial toothpaste |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569427A (en) * | 2017-10-17 | 2018-01-12 | 贵州云山环保再生循环科技有限公司 | A kind of Traditional Chinese medicine health-care toothpaste of the extract containing Polygonum multiflower knotweed |
-
2018
- 2018-02-01 CN CN201810101067.2A patent/CN108014053A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107569427A (en) * | 2017-10-17 | 2018-01-12 | 贵州云山环保再生循环科技有限公司 | A kind of Traditional Chinese medicine health-care toothpaste of the extract containing Polygonum multiflower knotweed |
Non-Patent Citations (2)
| Title |
|---|
| 刘永新编著: "《图解中草药大全》", 30 August 2017, 中医古籍出版社 * |
| 廖醒梦等编辑: "《精油芳疗养生事典》", 30 September 2005, 汕头大学出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159365A (en) * | 2021-12-24 | 2022-03-11 | 武汉爱民制药股份有限公司 | Antibacterial toothpaste |
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Application publication date: 20180511 |
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