CN106038425A - Herba Dendrobii toothpaste and preparation method thereof - Google Patents
Herba Dendrobii toothpaste and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention relates to Herba Dendrobii toothpaste and a preparation method thereof. Herba Dendrobii mixed wall-broken stock solution which contains Herba Dendrobii, green tea leaves and Radix Notoginseng is added in the formula of the toothpaste, the Herba Dendrobii mixed wall-broken stock solution is prepared by spectrum sterilizing and ultra-low-constant-temperature vibratory wall-broken pulverizing, the mixed wall-broken stock solution is prepared at the temperature of -2+/- 0.1 DEG C, and is stored at the low temperature of -2-0 DEG C, the cell wall-breaking rate reaches 98.5% or above, for a single Chinese medicinal herb breaking mode, the technology is broken through, the utilization rate of medicinal materials is increased, and the added value of the medicinal materials is increased. When the Herba Dendrobii mixed wall-broken stock solution is added in a toothpaste preparation process, a temperature control method is adopted, meanwhile, by mixing Herba Dendrobii, Radix Notoginseng and the green tea leaves, the efficacy is good, and the gingival self-repairing function can be improved. The Herba Dendrobii toothpaste has good inflammation diminishing and sterilizing effects, and facilitates health of teeth.
Description
Technical field
The present invention relates to the preparation method technical field of toothpaste and toothpaste, refer specifically to a kind of Herba Dendrobii toothpaste and preparation thereof
Method.
Background technology
Modern medicine, pharmacology of Chinese materia medica show, Herba Dendrobii rich in dendrobium polysaccharide, dendrobine, dendramine, Herba Dendrobii time alkali,
Mineral and the trace element such as multiple bioactive ingredients such as Herba Dendrobii (newly) alkali, 6-hydroxydendroxine etc. and potassium, magnesium, ferrum, have pole
High medical value and edible health are worth.
Effect of Herba Dendrobii mainly show as following some:
1, nourishing Tianjin: " China's pharmacy dictionary " title Herba Dendrobii " specially growing the gas-liquid of lung stomach, rush prosperous, and kidney water is certainly by gas-liquid
Raw ", it is good at YIN nourishing and the production of body fluid promoting, is the key medicine of yin nourishing, take Herba Dendrobii and can fundamentally solve the problem of human body YIN-fluid being insufficient,
The treatment all diseases of Yin and fluid deficiency；
2, health invigorating: Herba Dendrobii has the function of nourishing YIN and benefiting blood, Qing Dynasty's " property of medicine opinion " claims Herba Dendrobii energy the kidney invigorating to amass
Essence, nourishing stomach-YIN, physical strength profiting；Herba Dendrobii is contained within the polysaccharose substance enriched, and experiment proves dendrobium polysaccharide, can strengthen abdominal cavity huge
The phagocyte phagocytic activity to chicken red blood cell, has the effect strengthening immunologic function.
Herba Dendrobii is added in toothpaste, be expected to improve the self-regeneration function of gingiva, but, send out the most to greatest extent
The deep processing application of effect and Herba Dendrobii of waving Herba Dendrobii all becomes people and is devoted to a difficult problem for research in recent years.At present,
Relatively conventional Herba Dendrobii addition manner is to be made into Herba Dendrobii powder, adds in a medicament, but, common mode system
Become Herba Dendrobii powder mode cell-wall breaking ratio low, the overall utilization rate causing medical material is relatively low, and Herba Dendrobii powder with add
Adding main body and be difficult to mix homogeneously, the rate of release in human body and Chinese medicine preparation is low, affects further the performance of drug effect, except this with
The range of application of external iron sheet Herba Dendrobii is restricted, and added value is low.
Application publication number is the Chinese invention patent application " making of a kind of dendrobium officinale fresh juice stock solution of CN102008654A
Method " (application number: CN201010583151.6) disclose a kind of method extracting Herba Dendrobii stock solution, although produce smoothly
Herba Dendrobii stock solution and fresh juice stock solution content reach more than 99%, but it does not carries out broken wall treatment to Herba Dendrobii, and drug effect is released
Put effect poor, and need, at 115～120 DEG C, stock solution is carried out sterilization treatment, cause the drug effect of Herba Dendrobii at high temperature bar
Lose relatively big under part, the overall medical value of impact.
Application publication number is Chinese invention patent application " a kind of Herba Dendrobii toothpaste and the preparation side thereof of CN104116703A
Method " (application number: 201410354412.5) disclose a kind of method, its with the addition of in formulation of tooth-paste comprise polysaccharide, chlorophyll,
The Herba Dendrobii extract of vitamin and protein, although it uses cryogenic conditions in toothpaste preparation process more, but it uses
Herba Dendrobii is sterilized by boiling water, have impact on drug effect and the activity thereof of Herba Dendrobii the most to a certain extent.
Summary of the invention
The technical problem to be solved is the present situation for prior art, it is provided that a kind of medical material utilization rate is high, medicine
Effect is notable, can improve the Herba Dendrobii toothpaste of gingiva self-regeneration function.
To be solved by this invention another technical problem is that the present situation for prior art, it is provided that a kind of above-mentioned iron sheet stone
The preparation method of dry measure used in former times toothpaste, the method can be effectively improved the utilization rate of Herba Dendrobii, make Herba Dendrobii full and uniform incorporate tooth
In cream, play preferable drug effect.
The present invention solves the technical scheme that above-mentioned technical problem used: a kind of Herba Dendrobii toothpaste, it is characterised in that
Include following components by weight:
Sorbitol 20～37 parts, hydrated silica 8～22 parts, Herba Dendrobii mixing breaking cellular wall stock solution 4.4～18.8 parts, poly-second
Glycol-400 1～8 parts, sodium lauryl sulfate 0.8～5 parts, edible essence 0.05～4 parts, xanthan gum 0.1～2 parts, OK a karaoke club
Glue 0.05～1 part, cocamido propyl betaine 0.03～1 part, saccharin sodium 0.01～1 part, methyl hydroxybenzoate 0.01～1 part and
The ultra-pure water of 11.6～38.8 parts.
As preferably, include following components by weight: Sorbitol 30～37 parts, hydrated silica 18～22 parts, iron sheet
Herba Dendrobii mixing breaking cellular wall stock solution 10～15 parts, PEG-4000 4～6 parts, sodium lauryl sulfate 2～4 parts, edible essence 1～
3 parts, xanthan gum 0.5～1.5 parts, carrageenan 0.1～0.5 part, cocamido propyl betaine 0.1～0.5 part, saccharin sodium 0.1
～0.3 part, methyl hydroxybenzoate 0.3～0.6 part and the ultra-pure water of 14～27.6 parts.
Further preferably, Sorbitol 35 parts, hydrated silica 20 parts, Herba Dendrobii mixing breaking cellular wall stock solution 11.5 parts, poly-second
Glycol-400 5 parts, sodium lauryl sulfate 3 parts, edible essence 2 parts, xanthan gum 1 part, carrageenan 0.3 part, cocamidopropyl propyl amide
Glycine betaine 0.3 part, saccharin sodium 0.2 part, 0.5 part and 21.2 parts ultra-pure waters of methyl hydroxybenzoate.
As improvement, according to weight meter, described Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 4～16 parts, green tea
Leaf 0.3～2 parts, Radix Notoginseng 0.1～0.8 part and ultra-pure water, described Herba Dendrobii, green tea, gross weight and the ultra-pure water of Radix Notoginseng
Weight ratio≤1:1.3.
Improving further, the usage amount of described Herba Dendrobii, green tea and Radix Notoginseng is respectively Herba Dendrobii 10 parts, green tea
0.9 part, Radix Notoginseng 0.6 part.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6～11 minutes；
C, the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 6～11 minutes；
C, the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 3:
It is broken that a, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng carry out wall-broken micro powder in gnotobasis；
B, interpolation ultra-pure water, make the weight ratio≤1:1.3 of medicine total amount and water；
C, to carry out wall-broken micro powder broken, produces mixing breaking cellular wall stock solution at temperature is for-1.9～-2.1 DEG C, and cell-wall breaking ratio is
More than 98.5%；
D, the mixing breaking cellular wall stock solution produced first is sterilized with spectrum, then preserve at gnotobasis ,-2 DEG C～0 DEG C.
The preparation method of a kind of above-mentioned Herba Dendrobii toothpaste, it is characterised in that comprise the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate 95～120
DEG C constant temperature under carry out homogenizing stirring, mixing time is 10～20 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is stirred, and is kept stirring for state and is cooled to 50～75 DEG C；
2) controlling temperature is 60～80 DEG C, continues to add the xanthan gum of formula ratio, carrageenan in the first stirring thing, eat
Essence；
3) it is warming up to 90～95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) keep pressure-0.5～-0.1MPa, and keep constant temperature high-speed stirred, mixing speed be per minute 3000～
4000 turns, mixing time is 10～15 minutes, obtains the second stirring thing；
Step 3:
The second stirring thing step 2 obtained is cooled to 60～75 DEG C, and in cooling procedure, temperature reaches 78～86 DEG C
Time, to add the Herba Dendrobii mixing breaking cellular wall stock solution of formula ratio, carry out Quick uniform stirring, mixing time is 5 minutes, obtains the 3rd
Stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 25～26 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 20～30 DEG C, i.e. obtains described
Herba Dendrobii toothpaste.
In the preparation method of above-mentioned Herba Dendrobii toothpaste, according to weight meter, described Herba Dendrobii mixing breaking cellular wall stock solution bag
Include Herba Dendrobii 4～16 parts, green tea 0.3～2 parts, Radix Notoginseng 0.1～0.8 part and ultra-pure water, described Herba Dendrobii, green tea,
The gross weight of Radix Notoginseng and the weight ratio≤1:1.3 of ultra-pure water.
In the preparation method of above-mentioned Herba Dendrobii toothpaste, described Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps
:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6～11 minutes；
C, the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 6～11 minutes；
C, the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng carry out breaking cellular wall micronizing in gnotobasis；
B, interpolation ultra-pure water, make the weight ratio≤1:1.3 of medicine total amount and water；
C, carrying out breaking cellular wall micronizing, produce mixing breaking cellular wall stock solution at temperature-1.9～-2.1 DEG C, cell-wall breaking ratio is
More than 98.5%；
D, the mixing breaking cellular wall stock solution produced first is sterilized with spectrum, then preserve at gnotobasis ,-2 DEG C～0 DEG C.
Compared with prior art, it is an advantage of the current invention that: the present invention with the addition of in formulation of tooth-paste and comprises fresh ferrum
Skin Herba Dendrobii, green tea, the Herba Dendrobii mixing breaking cellular wall stock solution of Radix Notoginseng, the employing spectrum sterilization of this Herba Dendrobii mixing breaking cellular wall stock solution,
The preparation method acquisition that ultralow constant temperature vibration formula wall-broken micro powder is broken, produces at temperature is for-2 ± 0.1 DEG C and mixes breaking cellular wall stock solution, and-2
DEG C～0 DEG C of cryopreservation, cell-wall breaking ratio reaches more than 98.5%, has been sufficiently reserved its bioactive ingredients, simultaneously for single
Chinese herbal medicine grinding mode for be a kind of technical breakthrough, improve the utilization rate of medical material, add its added value；
The present invention, when preparing interpolation Herba Dendrobii mixing breaking cellular wall stock solution during toothpaste, uses temperature controlled method,
Improve mode with temperature indirect type and carry out lotion of toothpaste substrate stirring, finally when 78～86 DEG C quickly by lotion of toothpaste substrate with
Mixing breaking cellular wall stock solution is sufficiently mixed and was cooled to rapidly in 59 seconds room temperature, and meanwhile, Herba Dendrobii, Radix Notoginseng, green tea mix
Drug effect more preferably, Radix Notoginseng has anti-inflammation, analgesic effect, and catechin, theaflavin and the phenol in Folium Camelliae sinensis is to enteritis pathogenic bacteria
Having notable antibacterial action, malignant bacteria multiple to Staphylococcus aureus, Bacillus typhi etc. also has obvious inhibitory action, this and ferrum
The function of skin Herba Dendrobii plays synergism, can not only improve gingiva self-regeneration function, also has more preferable anti-inflammation and sterilization effect,
More effective than general medicated toothpaste for oral diseases such as oral ulcer, periodontitis, gingival hemorrhages, it is more beneficial for dental health；
It addition, added with the form of stock solution by Herba Dendrobii, Herba Dendrobii release efficiency can be made to increase substantially, compare traditional handicraft and
Speech can bring up to 70%, and it fully incorporates in toothpaste, preferably plays drug effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1:
The Herba Dendrobii toothpaste of the present embodiment includes following components by weight:
Sorbitol 35 parts, hydrated silica 20 parts, Herba Dendrobii mixing breaking cellular wall stock solution 11.5 parts, PEG-4000 5
Part, sodium lauryl sulfate 3 parts, edible essence 2 parts, xanthan gum 1 part, carrageenan 0.3 part, cocamido propyl betaine 0.3
Part, saccharin sodium 0.2 part, methyl hydroxybenzoate 0.5 part and the ultra-pure water of 21.2 parts.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 10 parts, green tea 0.9 part, Radix Notoginseng 0.6 part and ultrapure
Water, wherein, Herba Dendrobii, green tea, the gross weight of Radix Notoginseng and the weight ratio of ultra-pure water are 1:1.3.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, fresh Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6 minutes；
C, the cutting machine of the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed on spectrum sterilized environment
Under stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 6 minutes；
C, the cutting machine of the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment
Stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng are all inserted in the broken machine of vibration type wall-broken micro powder, and this shakes
The broken machine of dynamic formula wall-broken micro powder is aseptic condition；
B, in the broken machine of vibration type wall-broken micro powder add ultra-pure water, make the weight ratio=1:1.3 of medicine total amount and water；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, carefully at temperature is for-2 ± 0.1 DEG C
Born of the same parents' sporoderm-broken rate reaches more than 98.5%；
D, by the mixing breaking cellular wall stock solution produced first with spectrum sterilization insert again cryogenic sterile seal in container preserve stand-by, institute
State the storage temperature sealed in container and be-2 DEG C～0 DEG C.
The preparation method of the present embodiment Herba Dendrobii toothpaste comprises the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate the perseverance of 95 DEG C
Carrying out homogenizing stirring under the conditions of temperature, mixing time is 10 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is poured in de-airing mixer, is kept stirring for state and cools down, being cooled to
50℃；
2) controlling temperature is 60 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in de-airing mixer
Essence；
3) it is warming up to 90 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) opening vacuum pump, holding pressure is at-0.5MPa, and keeps constant temperature high-speed stirred, and mixing speed is per minute
3000 turns, mixing time is 10 minutes, obtains the second stirring thing, is cooled to 60 DEG C；
Step 3:
When the second stirring thing step 2 obtained is warming up to 78 DEG C, the Herba Dendrobii mixing breaking cellular wall adding formula ratio is former
Liquid, is kept stirring for 5 minutes obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 25 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 20 DEG C, i.e. obtains Herba Dendrobii
Toothpaste；
Step 6:
Herba Dendrobii toothpaste is carried out fill.
Embodiment 2:
The Herba Dendrobii toothpaste of the present embodiment includes following components by weight:
Sorbitol 30 parts, hydrated silica 14 parts, Herba Dendrobii mixing breaking cellular wall stock solution 8 parts, PEG-4000 4 part, month
Cinnamic alcohol sodium sulfovinate 3 parts, edible essence 2 parts, xanthan gum 0.1 part, carrageenan 0.05 part, cocamido propyl betaine 0.03
Part, saccharin sodium 0.01 part, methyl hydroxybenzoate 0.01 part and the ultra-pure water of 38.8 parts.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 7 parts, green tea 0.7 part, Radix Notoginseng 0.3 part and ultrapure
Water, wherein, Herba Dendrobii, green tea, the gross weight of Radix Notoginseng and the weight ratio of ultra-pure water are 1:1.3.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 11 minutes；
C, the cutting machine of the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed on spectrum sterilized environment
Under stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 11 minutes；
C, the cutting machine of the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment
Stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng are all inserted in the broken machine of vibration type wall-broken micro powder, and this shakes
The broken machine of dynamic formula wall-broken micro powder is aseptic condition；
B, in the broken machine of vibration type wall-broken micro powder add ultra-pure water, make the weight ratio=1:1.3 of medicine total amount and water；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, carefully at temperature is for-2 ± 0.1 DEG C
Born of the same parents' sporoderm-broken rate reaches more than 98.5%；
D, by the mixing breaking cellular wall stock solution produced first with spectrum sterilization insert again cryogenic sterile seal in container preserve stand-by, institute
State the storage temperature sealed in container and be-2 DEG C～0 DEG C.
The preparation method of the present embodiment Herba Dendrobii toothpaste comprises the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate at 120 DEG C
Carrying out homogenizing stirring under constant temperature, mixing time is 20 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is poured in de-airing mixer, is kept stirring for state and cools down, being cooled to
75℃；
2) controlling temperature is 80 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in de-airing mixer
Essence；
3) it is warming up to 95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) opening vacuum pump, holding pressure is at-0.1MPa, and keeps constant temperature high-speed stirred, and mixing speed is per minute
4000 turns, mixing time is 15 minutes, obtains the second stirring thing, is cooled to 75 DEG C；
Step 3:
When the second stirring thing step 2 obtained is warming up to 86 DEG C, the Herba Dendrobii mixing breaking cellular wall adding formula ratio is former
Liquid, is kept stirring for 5 minutes obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 26 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 30 DEG C, i.e. obtains described ferrum
Skin Herba Dendrobii toothpaste；
Step 6:
Herba Dendrobii toothpaste is carried out fill.
Embodiment 3:
The Herba Dendrobii toothpaste of the present embodiment includes following components by weight:
Sorbitol 28 parts, hydrated silica 20 parts, Herba Dendrobii mixing breaking cellular wall stock solution 18.8 parts, PEG-4000 8
Part, sodium lauryl sulfate 5 parts, edible essence 4 parts, xanthan gum 2 parts, carrageenan 1 part, cocamido propyl betaine 1 part, sugar
1 part of sodium of essence, methyl hydroxybenzoate 1 part and the ultra-pure water of 10.2 parts.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 16 parts, green tea 2 parts, Radix Notoginseng 0.8 part and ultra-pure water,
Wherein, Herba Dendrobii, green tea, the gross weight of Radix Notoginseng are 1:1.4 with the weight ratio of ultra-pure water.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 10 minutes；
C, the cutting machine of the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed on spectrum sterilized environment
Under stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 11 minutes；
C, the cutting machine of the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment
Stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng are all inserted in the broken machine of vibration type wall-broken micro powder, and this shakes
The broken machine of dynamic formula wall-broken micro powder is aseptic condition；
B, in the broken machine of vibration type wall-broken micro powder add ultra-pure water, make the weight ratio=1:1.4 of medicine total amount and water；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, carefully at temperature is for-2 ± 0.1 DEG C
Born of the same parents' sporoderm-broken rate reaches more than 98.5%；
D, by the mixing breaking cellular wall stock solution produced first with spectrum sterilization insert again cryogenic sterile seal in container preserve stand-by, institute
State the storage temperature sealed in container and be-2 DEG C～0 DEG C.
The preparation method of the present embodiment Herba Dendrobii toothpaste comprises the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate at 100 DEG C
Carrying out homogenizing stirring under constant temperature, mixing time is 15 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is poured in de-airing mixer, is kept stirring for state and cools down, being cooled to
55℃；
2) controlling temperature is 70 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in de-airing mixer
Essence；
3) it is warming up to 92 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) opening vacuum pump, holding pressure is at-0.2MPa, and keeps constant temperature high-speed stirred, and mixing speed is per minute
3500 turns, mixing time is 13 minutes, obtains the second stirring thing, is cooled to 65 DEG C；
Step 3:
When the second stirring thing step 2 obtained is warming up to 80 DEG C, the Herba Dendrobii mixing breaking cellular wall adding formula ratio is former
Liquid, is kept stirring for 5 minutes obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 25 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 20 DEG C, i.e. obtains described ferrum
Skin Herba Dendrobii toothpaste；
Step 6:
Herba Dendrobii toothpaste is carried out fill.
Embodiment 4:
The Herba Dendrobii toothpaste of the present embodiment includes following components by weight:
Sorbitol 30 parts, hydrated silica 18 parts, Herba Dendrobii mixing breaking cellular wall stock solution 10 parts, PEG-4000 4 parts,
Sodium lauryl sulfate 2 parts, edible essence 1 part, xanthan gum 0.5 part, carrageenan 0.1 part, cocamido propyl betaine 0.1
Part, saccharin sodium 0.1 part, methyl hydroxybenzoate 0.3 part and the ultra-pure water of 33.9 parts.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 8 parts, green tea 1.5 parts, Radix Notoginseng 0.5 part and ultrapure
Water, wherein, Herba Dendrobii, green tea, the gross weight of Radix Notoginseng and the weight ratio of ultra-pure water are 1:1.35.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 8 minutes；
C, the cutting machine of the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed on spectrum sterilized environment
Under stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 10 minutes；
C, the cutting machine of the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment
Stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng are all inserted in the broken machine of vibration type wall-broken micro powder, and this shakes
The broken machine of dynamic formula wall-broken micro powder is aseptic condition；
B, in the broken machine of vibration type wall-broken micro powder add ultra-pure water, make the weight ratio=1:1.35 of medicine total amount and water；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, carefully at temperature is for-2 ± 0.1 DEG C
Born of the same parents' sporoderm-broken rate reaches more than 98.5%；
D, by the mixing breaking cellular wall stock solution produced first with spectrum sterilization insert again cryogenic sterile seal in container preserve stand-by, institute
State the storage temperature sealed in container and be-2 DEG C～0 DEG C.
The preparation method of the present embodiment Herba Dendrobii toothpaste comprises the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate at 120 DEG C
Carrying out homogenizing stirring under constant temperature, mixing time is 12 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is poured in de-airing mixer, is kept stirring for state and cools down, being cooled to
65℃；
2) controlling temperature is 75 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in de-airing mixer
Essence；
3) it is warming up to 95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) opening vacuum pump, holding pressure is at-0.3MPa, and keeps constant temperature high-speed stirred, and mixing speed is per minute
4000 turns, mixing time is 10 minutes, obtains the second stirring thing, is cooled to 62 DEG C；
Step 3:
When the second stirring thing step 2 obtained is warming up to 82 DEG C, the Herba Dendrobii mixing breaking cellular wall adding formula ratio is former
Liquid, is kept stirring for 5 minutes obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 26 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 30 DEG C, i.e. obtains described ferrum
Skin Herba Dendrobii toothpaste；
Step 6:
Herba Dendrobii toothpaste is carried out fill.
Embodiment 5:
The Herba Dendrobii toothpaste of the present embodiment includes following components by weight:
Sorbitol 37 parts, hydrated silica 22 parts, Herba Dendrobii mixing breaking cellular wall stock solution 15 parts, PEG-4000 6 parts,
Sodium lauryl sulfate 4 parts, edible essence 1 part, xanthan gum 1.5 parts, carrageenan 0.5 part, cocamido propyl betaine 0.5
Part, saccharin sodium 0.3 part, methyl hydroxybenzoate 0.6 part and the ultra-pure water of 11.6 parts.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 13.7 parts, green tea 0.7 part, Radix Notoginseng 0.6 part and surpasses
Pure water, wherein, Herba Dendrobii, green tea, the gross weight of Radix Notoginseng and the weight ratio of ultra-pure water are 1:1.4.
Above-mentioned Herba Dendrobii mixing breaking cellular wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6 minutes；
C, the cutting machine of the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed on spectrum sterilized environment
Under stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 8 minutes；
C, the cutting machine of the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment
Stand-by；
Step 3:
A, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng are all inserted in the broken machine of vibration type wall-broken micro powder, and this shakes
The broken machine of dynamic formula wall-broken micro powder is aseptic condition；
B, in the broken machine of vibration type wall-broken micro powder add ultra-pure water, make the weight ratio=1:1.4 of medicine total amount and water；
C, to carry out ultralow constant temperature vibration formula wall-broken micro powder broken, produces mixing breaking cellular wall stock solution, carefully at temperature is for-2 ± 0.1 DEG C
Born of the same parents' sporoderm-broken rate reaches more than 98.5%；
D, by the mixing breaking cellular wall stock solution produced first with spectrum sterilization insert again cryogenic sterile seal in container preserve stand-by, institute
State the storage temperature sealed in container and be-2 DEG C～0 DEG C.
The preparation method of the present embodiment Herba Dendrobii toothpaste comprises the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate the perseverance of 95 DEG C
Carrying out homogenizing stirring under the conditions of temperature, mixing time is 20 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is poured in de-airing mixer, is kept stirring for state and cools down, being cooled to
75℃；
2) controlling temperature is 80 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in de-airing mixer
Essence；
3) it is warming up to 90 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) opening vacuum pump, holding pressure is at-0.1MPa, and keeps constant temperature high-speed stirred, and mixing speed is per minute
4000 turns, mixing time is 13 minutes, obtains the second stirring thing, is cooled to 75 DEG C；
Step 3:
The second stirring thing step 2 obtained is warming up to 78 DEG C, adds the Herba Dendrobii mixing breaking cellular wall stock solution of formula ratio,
It is kept stirring for 5 minutes obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 26 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 30 DEG C, i.e. obtains described ferrum
Skin Herba Dendrobii toothpaste；
Step 6:
Herba Dendrobii toothpaste is carried out fill.
The present embodiment is to using minimum antibacterial dense to antibacterial of the Herba Dendrobii mixing breaking cellular wall stock solution prepared of the inventive method
Degree is detected, and detailed process is:
By fluid medium and centrifuge tube in 121 DEG C of sterilizing 20min, after cooling, each in test tube add 0.5mL liquid culture
Base, according to doubling dilution, Herba Dendrobii mixing breaking cellular wall stock solution doubling dilution joins 1.5mg/mL, 1mg/mL, 0.75mg/mL,
0.5mg/mL, 0.25mg/mL and 0.125mg/mL.Often the corresponding test organisms 0.1mL of each addition in group test tube, shakes up.Test tube is put
In 37 DEG C of constant incubators, cultivate 24h, observe bacterial growth situation.
Result:
Table 1 Herba Dendrobii mixing breaking cellular wall stock solution is to antibacterial minimum inhibitory concentration (mg/ml)
| Bacterial species | Condition of culture | Herba Dendrobii vibration micropowder breaking cellular wall stock solution | Herba Dendrobii rotates micropowder breaking cellular wall stock solution |
| Staphylococcus aureus | (A) | 0.03 | 0.07 |
| Escherichia coli | (A) | 0.07 | 0.08 |
| Salmonella | (A) | 0.09 | 1.25 |
Note: (A) aerobic conditions.
As shown in Table 1, the Herba Dendrobii mixing breaking cellular wall that in the present invention, the ultralow constant temperature vibration broken mode of formula wall-broken micro powder obtains
Stock solution is strong for the inhibitory action of the harmful bacterias such as staphylococcus aureus, escherichia coli, salmonella.Illustrate by the present invention
Herba Dendrobii that the ultralow constant temperature vibration broken mode of formula wall-broken micro powder obtains, Radix Notoginseng, the green tea mixing effective dissolution rate of stock solution are high, medicine
Effect is strong, and the effect of bactericidal antiphlogistic is more preferably.
The present embodiment also to the Herba Dendrobii mixing breaking cellular wall stock solution using the inventive method to prepare, Herba Dendrobii toothpaste is to two
Toluene causes mice auricle swelling impact and is detected, and detailed process is:
Taking female rats 40, be randomly divided into 4 groups, often group 10, gives corresponding external dimethylbenzene in each treated animal auricle
Uniform application (consumption 0.1ml), to cause inflammatory reaction.It is blank group (water, 30ml/kg), iron sheet after causing scorching latter 1 hour
Herba Dendrobii toothpaste (1.38g/kg is equivalent to fresh medical material 0.135g/kg), Herba Dendrobii vibration micropowder breaking cellular wall stock solution (0.12g/
Kg), Herba Dendrobii rotation micropowder breaking cellular wall stock solution (0.14g/kg) smears auris dextra exterior feature.Mice takes off after smearing 1 hour cervical vertebra put to death,
Being cut by auricle right, left, make round auricle (diameter 9mm), analytical balance is weighed, every animal auricle weight difference right, left, the most instead
Reflect inflammation swelling degree.Between many groups, mean compares employing variance analysis, and all data are carried out with by SPSS 17.0 statistical software
Process.
Result:
Table 2 Herba Dendrobii mixing breaking cellular wall stock solution xylol causes the impact of mice auricle swelling
As shown in Table 2, the ultralow constant temperature vibration broken mode of formula wall-broken micro powder in the Herba Dendrobii toothpaste of the present invention and the present invention
Obtain Herba Dendrobii mixing breaking cellular wall stock solution suppression ratio higher, illustrate that breaking cellular wall stock solution fully incorporates in toothpaste, detumescence effect and rush
Repairing effect is more preferable.
Claims (9)
1. a Herba Dendrobii toothpaste, it is characterised in that include following components by weight:
Sorbitol 20～37 parts, hydrated silica 8～22 parts, Herba Dendrobii mixing breaking cellular wall stock solution 4.4～18.8 parts, poly-second two
Alcohol-400 1～8 parts, sodium lauryl sulfate 0.8～5 parts, edible essence 0.05～4 parts, xanthan gum 0.1～2 parts, carrageenan
0.05～1 part, cocamido propyl betaine 0.03～1 part, saccharin sodium 0.01～1 part, methyl hydroxybenzoate 0.01～1 part and
The ultra-pure water of 11.6～38.8 parts.
Herba Dendrobii toothpaste the most according to claim 1, it is characterised in that include following components by weight: Sorbitol
30～37 parts, hydrated silica 18～22 parts, Herba Dendrobii mixing breaking cellular wall stock solution 10～15 parts, PEG-4000 4～6 part, month
Cinnamic alcohol sodium sulfovinate 2～4 parts, edible essence 1～3 parts, xanthan gum 0.5～1.5 parts, carrageenan 0.1～0.5 part, coconut oleoyl amine
CAB 0.1～0.5 part, saccharin sodium 0.1～0.3 part, methyl hydroxybenzoate 0.3～0.6 part and 14～27.6 parts ultrapure
Water.
Herba Dendrobii toothpaste the most according to claim 2, it is characterised in that include following components by weight: Sorbitol
35 parts, hydrated silica 20 parts, Herba Dendrobii mixing breaking cellular wall stock solution 11.5 parts, PEG-4000 5 parts, sodium lauryl sulfate 3
Part, edible essence 2 parts, xanthan gum 1 part, carrageenan 0.3 part, cocamido propyl betaine 0.3 part, saccharin sodium 0.2 part, oxybenzene
Methyl ester 0.5 part and the ultra-pure water of 21.2 parts.
4. according to the Herba Dendrobii toothpaste described in claim 1 or 2 or 3, it is characterised in that: described Herba Dendrobii mixing breaking cellular wall is former
Liquid includes Herba Dendrobii 4～16 parts, green tea 0.3～2 parts, Radix Notoginseng 0.1～0.8 part and ultra-pure water, described Herba Dendrobii, green tea
Leaf, the gross weight of Radix Notoginseng and the weight ratio≤1:1.3 of ultra-pure water.
Herba Dendrobii toothpaste the most according to claim 4, it is characterised in that: described Herba Dendrobii, green tea and Radix Notoginseng
Usage amount is respectively Herba Dendrobii 10 parts, green tea 0.9 part, Radix Notoginseng 0.6 part.
Herba Dendrobii toothpaste the most according to claim 4, it is characterised in that described Herba Dendrobii mixing breaking cellular wall stock solution by with
Lower step obtains:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6～11 minutes；
C, the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 6～11 minutes；
C, the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 3:
It is broken that a, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng carry out wall-broken micro powder in gnotobasis；
B, interpolation ultra-pure water, make the weight ratio≤1:1.3 of medicine total amount and water；
C, to carry out wall-broken micro powder broken, produces mixing breaking cellular wall stock solution at temperature is for-1.9～-2.1 DEG C, and cell-wall breaking ratio is
More than 98.5%；
D, the mixing breaking cellular wall stock solution produced first is sterilized with spectrum, then preserve at gnotobasis ,-2 DEG C～0 DEG C.
7. the preparation method of a Herba Dendrobii toothpaste as claimed in claim 1, it is characterised in that comprise the following steps:
Step one:
By the ultra-pure water of formula ratio, hydrated silica, cocamido propyl betaine, sodium lauryl sulfate at 95～120 DEG C
Carrying out homogenizing stirring under constant temperature, mixing time is 10～20 minutes, obtains the first stirring thing；
Step 2:
1) the first stirring thing step one obtained is stirred, and is kept stirring for state and is cooled to 50～75 DEG C；
2) controlling temperature is 60～80 DEG C, continues to add the xanthan gum of formula ratio, carrageenan, edible perfume in the first stirring thing
Essence；
3) it is warming up to 90～95 DEG C, adds the methyl hydroxybenzoate of formula ratio, PEG-4000, saccharin sodium, Sorbitol；
4) keeping pressure-0.5～-0.1MPa, and to be kept stirring for speed be 3000～4000 turns per minute, and mixing time is 10
～15 minutes, obtain the second stirring thing, be cooled to 60～75 DEG C；
Step 3:
When the second stirring thing step 2 obtained is warmed up to 78～86 DEG C, the Herba Dendrobii mixing breaking cellular wall adding formula ratio is former
Liquid, is kept stirring for obtaining the 3rd stirring thing；
Step 4:
The 3rd stirring thing obtained in step 3 is lowered the temperature rapidly, in 59 seconds, cools the temperature to 25～26 DEG C；
Step 5:
The 3rd stirring thing after being lowered the temperature by step 4 gained places ageing, and Aging Temperature is 20～30 DEG C, i.e. obtains described ferrum
Skin Herba Dendrobii toothpaste.
The preparation method of Herba Dendrobii toothpaste the most according to claim 7, it is characterised in that: according to weight meter, described ferrum
Skin Herba Dendrobii mixing breaking cellular wall stock solution includes Herba Dendrobii 4～16 parts, green tea 0.3～2 parts, Radix Notoginseng 0.1～0.8 part and ultra-pure water,
Described Herba Dendrobii, green tea, the gross weight of Radix Notoginseng and the weight ratio≤1:1.3 of ultra-pure water.
The preparation method of Herba Dendrobii toothpaste the most according to claim 8, it is characterised in that the mixing of described Herba Dendrobii is broken
Wall stock solution is obtained by following steps:
Step 1:
The sorting of a, Herba Dendrobii is cleaned；
B, by clean Herba Dendrobii spectrum sterilizing 6～11 minutes；
C, the Herba Dendrobii after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 2:
The sorting of a, green tea is cleaned；
B, by clean green tea spectrum sterilizing 6～11 minutes；
C, the green tea after spectrum sterilizing is shredded, obtain cutting off thing, and be placed under spectrum sterilized environment stand-by；
Step 3:
It is broken that a, sterilization step 1 and step 2 obtained cut-out thing and Radix Notoginseng carry out wall-broken micro powder in gnotobasis；
B, interpolation ultra-pure water, make the weight ratio≤1:1.3 of medicine total amount and water；
C, to carry out wall-broken micro powder broken, produces mixing breaking cellular wall stock solution at temperature is for-1.9～-2.1 DEG C, and cell-wall breaking ratio is
More than 98.5%；
D, the mixing breaking cellular wall stock solution produced first is sterilized with spectrum, then preserve at gnotobasis ,-2 DEG C～0 DEG C.
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| CN113576995A (en) * | 2021-08-25 | 2021-11-02 | 四川干邦亚农业科技有限公司 | Dendrobium anti-inflammation toothpaste and preparation method thereof |
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Application publication date: 20161026 |