CN107028850A

CN107028850A - Dendrobium candidum toothpaste and its preparation technology with oral restoration function

Info

Publication number: CN107028850A
Application number: CN201710270875.7A
Authority: CN
Inventors: 周玉寅
Original assignee: Shanghai Jade Biotechnology Co Ltd
Current assignee: Shanghai Jade Biotechnology Co Ltd
Priority date: 2017-04-24
Filing date: 2017-04-24
Publication date: 2017-08-11

Abstract

The present invention relates to oral cleaning field, more particularly it relates to a kind of dendrobium candidum toothpaste and its preparation technology with oral restoration function.A kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, at least including following components：First 0.1~1.0 part of dendrobium candidum extract；1.0~10 parts of bletilla striata extract；15.0~35.0 parts of D-sorbite；8.0~25.0 parts of hydrated silica；5.0~12.0 parts of glycerine；1.0~3.0 parts of borneol；1.0~6.0 parts of pearl shell powder；0.5~3.0 part of laruyl alcohol sodium sulfovinate；1.0~10.0 parts of polyethylene glycol；0.5~3.0 part of xylitol；0.3~1.0 part of sodium carboxymethylcellulose；0.1~1.0 part of Chondrus crispus；0.1~1.0 part of xanthans；3.0~8.0 parts of saccharin sodium；1.0~3.0 parts of C119140；1.0~3.0 parts of C142090；10~40 parts of water.

Description

Dendrobium candidum toothpaste and its preparation technology with oral restoration function

Technical field

The present invention relates to oral cleaning field, more particularly it relates to a kind of iron sheet with oral restoration function Stem of noble dendrobium toothpaste and its preparation technology.

Background technology

Dendrobium candidum is orchid family Dendrobium Sw, is a kind of herbaceos perennial, is also known as in some places：Yunnan iron The skin stem of noble dendrobium, black knot grass etc., its stem are rich in dendrobine, polysaccharide, amino acid and mineral matter and other components.Modern pharmacological research shows iron sheet Dendrobium polysaccharide has hypoglycemic, reducing blood lipid, increase immunity of organisms, suppresses tumour, protect liver cholagogic, anti-oxidant, anti-aging and expansion Open the effect such as blood vessel.It is distributed mainly on the ground such as Fujian China, Zhejiang, Anhui, Yunnan.With strengthening spleen and nourishing stomach, enriching yin and nourishing kidney, moistening lung The effects such as promoting the production of body fluid, for treating the diseases such as atrophic gastritis, hypertension, diabetes and antitumor, cataract.The Eastern Han Dynasty 《Sheng Nong's herbal classic》Just it is classified as top grade, version in 2010《Pharmacopoeia of People's Republic of China》Its single-row is pushed away for ancient Chinese medicine doctor It is high.

Dendrobium candidum nature and flavor：It is sweet, it is slightly cold, enters stomach, kidney channel.Property belong to clear and rich, it is clear in have benefit, bowl spares has clearly.

The efficacy effect of dendrobium candidum, the successive dynasties, name doctor respectively had discussion：

《Explaining abstruseness of the canon of materia medica》Cloud：" stem of noble dendrobium, it is sweet to please spleen, salty energy kidney-nourishing, therefore many work(are dirty in water and soil two：But gas is wide slow, no victory The work(played, ancients are with this generation tea, on very clear diaphragm.”

《A Supplement to the Compendium of Materia Medica》Cloud：" stem of noble dendrobium clearing stomach except abnormal heat, promote the production of body fluid and strained, with generation tea, work(is with joining stilbene.”

《The property of medicine》The middle load stem of noble dendrobium " for tea, promote the production of body fluid and wet one's whistle, Qiang Yinjian foot power by summer." visible, the stem of noble dendrobium is as being of illnesses and fitness High tonic is long-standing.The traditional Chinese medical science thinks that the stem of noble dendrobium is in diseases such as atrophic gastritis, tumour, diabetes, sphagitis and cataract Can extensive use in disease treatment.Dendrobium candidum has multiple pharmacological effect, such as strengthens the immunocompetence of body, anti-oxidant, anti- Aging, reduces blood glucose, nourishing Yin and promoting production of body fluid etc..The traditional Chinese medical science thinks, " yin and yang in equilibrium, life activities being normally maintained." such as yin jin virtual loss, it is impossible to contain sun, Sun is floating without system, and equilibrium between yin and yang is destroyed, then all diseases are grown thickly.”

《Ling Shu Miraculous Pivot or Divine Axis Benshen》Say：" the main store essential substances person of the five internal organs, can not hinder, and wound is then fallen into enemy hands and the deficiency of Yin, and the deficiency of Yin is then without gas, nothing Gas is then dead." dendrobium candidum exactly Yin-nourishing and body fluid promoting key medicine, the human world thus be referred to as " help celestial grass ".

《Sheng Nong's herbal classic》：In main wound, the thick stomach of eliminating impediment, lower gas, the thin thin, Qiang Yin of tonifying five zang organs consumptive disease, long term usage.

《Compendium of Materia Medica》：Strong the moon strengthening the essence.Never sufficient, flat stomach gas, long muscle, by oral cavity heat symptoms caused by an exopathgen miliaria in long term usage, thick stomach, benefit Gas, the cold numbness of pin knee pain is weak, determines intelligence except frightened, macrobiosis of making light of one's life by commiting suicide.

《Detailed outline is picked up any lost article from the road》：Clearing stomach remove abnormal heat, promote the production of body fluid the sixth of the twelve Earthly Branches strain, with generation tea, Appetizing spleen-tonifying.Arresting convulsion treatment wind, energy town saliva phlegm, Sweet fragrant sending down abnormally ascending.

《Medicineization justice》：Control lung qi empty long, cough is more than.

《Do not record》：Never sufficient, flat stomach gas in strengthening the essence benefit, long muscle, by oral cavity heat symptoms caused by an exopathgen gas, pin knee pain is weak, is good for positive, kidney tonifying Product essence.

《Japan hanako materia medica》：Governance wasting it is bad it is weak strengthen the bone, warming the kidney, intelligence development, flat stomach gas, by empty evil.

《Book on Chinese herbal medicine is new again》：Manage stomach Qi, clearing stomach fire.The polydipsia except in the minds of, treats kidney channel abnormal heat, and arresting convulsion of calming the nerves solves night sweat, can dissipated Heat.

Canker sore, also known as " aphtha ", is a kind of common oral keritonocytes, is the integrality of Oral mucosa keratinocyte Generation continuation defect or destruction, superficial necrosis come off to form depression.The cause of disease is complex, may be immune with mucosal epithelium layer Reconstruction of The Function imbalance is protected to have close relationship after abnormal reaction and mucosa injury.Numerous studies show that canker sore is sent out Disease is related to following factors：Heredity, immune disorder, wound, virus or bacterium infection, autoimmunity, enterogastric diseases, anaemia, Endocrinopathy, nutritional deficiency and stress etc..The incidence of disease of canker sore is very high, and the incidence of disease of population may be up to More than 25%.It is wherein most commonly seen with recurrent oral ulceration, it is cured when sending out at that time, recurrent exerbation, the course of disease is generally 7-10 days, hair There is more violent cusalgia during work, the work, studying and living to patient bring strong influence, have a strong impact on patient's Quality of life.

The method of current clinical treatment canker sore can substantially be divided into " external therapy " and " internal therapy "." external therapy " is main Anti-inflammatory, analgesic, anti-corrosion and the treatment for promoting healing are carried out for ulcer wound surface；And " internal therapy " then usually for immune system and Metabolism disorder is carried out, conventional to take vitamin, antimicrobial, hormone medicine or traditional Chinese medicine ingredients orally to be treated.But, " control outside Method " is although affected part surface can be directly acted on, and instant effect simultaneously can alleviate the pain that disease is brought, and it but refers to sometimes Mark is not effected a permanent cure, therefore usually has a recurrence, and pain repeatedly is brought to patient；" internal therapy " focuses on the free of interest of regulation patient itself Function, although be capable of the recurrence of canker sore, but it is slow to take effect, and the pain that disease is brought can not be alleviated." control outside Method " at present frequently with pharmaceutical dosage form mainly have gargle, paster etc., they can make medicine directly act on affected part；And " inside control The medicine of method " then usually from common various peroral dosage forms.

In order to live conveniently, it is also very desirable to by developing a product, both can treat mouth again as commodity Chamber disease.

The content of the invention

In order to solve the above problems, the invention provides a kind of dendrobium candidum toothpaste with oral restoration function, with weight Part meter is measured, at least including following components：

First 0.1~1.0 part of dendrobium candidum extract；1.0~10 parts of bletilla striata extract；D-sorbite 15.0~35.0 Part；8.0~25.0 parts of hydrated silica；5.0~12.0 parts of glycerine；1.0~3.0 parts of borneol；1.0~6.0 parts of pearl shell powder；Bay 0.5~3.0 part of alcohol sulfuric ester sodium；1.0~10.0 parts of polyethylene glycol；0.5~3.0 part of xylitol；Sodium carboxymethylcellulose 0.3~ 1.0 part；0.1~1.0 part of Chondrus crispus；0.1~1.0 part of xanthans；3.0~8.0 parts of saccharin sodium；C119140 1.0~3.0 Part；1.0~3.0 parts of C142090；10~40 parts of water；

The extracting method of the first dendrobium candidum extract is：By fresh dendrobium candidum sequentially pass through cleaning, sterilization, Crush, obtain dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately in ethanol solution, at 15~30 DEG C, 1~5h of ultrasonic extraction is carried out, obtained solution is filtered, filtrate obtains the first dendrobium candidum after being concentrated under reduced pressure into no ethanol Extract；

The extracting method of the bletilla striata extract is：The fresh bletilla striata is sequentially passed through into cleaning, sterilization, crushed, obtains white Splendid achnatherum powder；Common bletilla is soaked into 1~3h in mass concentration is 10% sodium chloride solution, then 1h is refrigerated at -5 DEG C, Obtain common bletilla solution；Common bletilla solution, chitosan are added separately to return in the ethanol solution that volume fraction is 10% Stream extracts 1~2h, and obtained solution is filtered, and filtrate obtains bletilla striata extract after being concentrated under reduced pressure into no ethanol.

It is used as a kind of preferred technical scheme of the present invention, the dendrobium candidum toothpaste with oral restoration function, with weight Part meter is measured, at least including following components：

First 0.5~0.8 part of dendrobium candidum extract；3~8 parts of bletilla striata extract；20.0~30.0 parts of D-sorbite；Water Close 15.0~20.0 parts of silica；8.0~10.0 parts of glycerine；1.0~3.0 parts of borneol；3.0~5.0 parts of pearl shell powder；Laruyl alcohol sulphur 1.0~2.5 parts of acid esters sodium；3.0~10.0 parts of polyethylene glycol；1.0~2.5 parts of xylitol；Sodium carboxymethylcellulose 0.5~1.0 Part；0.3~0.8 part of Chondrus crispus；0.5~1.0 part of xanthans；4.0~6.0 parts of saccharin sodium；1.5~3.0 parts of C119140； 2.0~3.0 parts of C142090；20~35 parts of water；

First 0.5 part of dendrobium candidum extract；7 parts of bletilla striata extract；25.0 parts of D-sorbite；18.0 parts of hydrated silica； 9.0 parts of glycerine；2.0 parts of borneol；4.0 parts of pearl shell powder；2.0 parts of laruyl alcohol sodium sulfovinate；8.0 parts of polyethylene glycol；Xylitol 2.0 Part；1.0 parts of sodium carboxymethylcellulose；0.5 part of Chondrus crispus；1.0 parts of xanthans；5.0 parts of saccharin sodium；2.0 parts of C119140； 3.0 parts of C142090；30 parts of water；

As a kind of preferred technical scheme of the present invention, in the extracting method of the first dendrobium candidum extract, iron sheet Weight ratio between Dendrobium, chitosan is：(10~100)：1.

As a kind of preferred technical scheme of the present invention, in the extracting method of the first dendrobium candidum extract, ethanol Volume ratio with water is：10：(10~90).

As a kind of preferred technical scheme of the present invention, the dendrobium candidum is the dendrobium candidum grown nonparasitically upon another plant on strawberry tree.

As a kind of preferred technical scheme of the present invention, supersonic frequency used in the ultrasonic extraction is 30~ 100kHz。

As a kind of preferred technical scheme of the present invention, the dendrobium candidum toothpaste with oral restoration function also includes Second dendrobium candidum extract；

The extracting method of the second dendrobium candidum extract is：

By dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar mixture, mix powder is ground to form, by mixture Powder is added to volume fraction in 20% ethanol solution, at 20~40 DEG C, to carry out 1~5h of ultrasonic extraction, molten by what is obtained Liquid is filtered, and filtrate obtains the second dendrobium candidum extract after being concentrated under reduced pressure into no ethanol.

As a kind of preferred technical scheme of the present invention, between the dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar Weight ratio be 100：(1~8)：(0.1~1)：(3~15)：(0.5~3).

The second aspect of the invention provides a kind of preparation technology of the dendrobium candidum toothpaste with oral restoration function, At least comprise the following steps：

Each component is weighed by weight, by D-sorbite, hydrated silica, glycerine, borneol, pearl shell powder, laruyl alcohol sulfuric acid After ester sodium, Chondrus crispus, xanthans and water mixing, homogeneous stirring is carried out under 70~100 DEG C of constant temperature, during stirring Between be 15~30 minutes after, then into system add polyethylene glycol, xylitol, sodium carboxymethylcellulose, xanthans, saccharin sodium, C119140, C142090, then system be warming up to 110~150 DEG C, mixing time is 15~60 minutes；Then by system temperature 40~60 DEG C are down to, dendrobium candidum extract, bletilla striata extract is separately added into, be again stirring for after 30 minutes being cooled to 25 rapidly~ 26 DEG C, and at 25~30 DEG C, be aged 5h, obtain the dendrobium candidum toothpaste with oral restoration function.

The above-mentioned of the application and other features, aspect and advantage is more readily understood with reference to described further below.

Embodiment

The participation in the election detailed description of the invention below for being preferable to carry out method and including embodiment this public affairs can be more easily understood Open content.A large amount of terms can be referred in description below and claims, these terms are defined as following meanings.

As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ", " having ", " containing " or its any other deformation, it is intended that cover including for non-exclusionism.For example, the combination comprising listed elements Thing, step, method, product or device are not necessarily limited to those key elements, but can include not expressly listed other key elements or Such a composition, step, method, product or the intrinsic key element of device." optionally " or " optionally " refer to describe thereafter Item or event may or may not occur, and the description includes the situation and the situation that does not occur of event that event occurs.

Equivalent, concentration or other values or parameter are excellent with scope, preferred scope or a series of upper limit preferred values and lower limit During the Range Representation that choosing value is limited, this, which is appreciated that, specifically discloses by any range limit or preferred value and any scope All scopes that any pairing of lower limit or preferred value is formed, regardless of whether whether the scope separately discloses.For example, when open During scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1~2 ", " 1~2 and 4~ 5 ", " 1~3 and 5 " etc..When number range is described herein, unless otherwise indicated, otherwise the scope is intended to include its end Value and all integers and fraction within the range.

Dendrobium candidum extract

In the present invention, the dendrobium candidum alias iron sheet is blue, ribbed hedyotis herb.It is orchid family Dendrobium herbaceos perennial, is One of superfine product in stem of noble dendrobium class Chinese medicine, its medical value and health-care efficacy are considered as being higher than other stems of noble dendrobium, enjoy high praise.Iron sheet The stem of noble dendrobium is the drying stem of orchid family Dendrobium Sw dendrobium candidum, because epidermis is gained the name in iron green.Dendrobium Sw is by form, production Ground etc. can be divided into the dozens of kinds such as iron sheet, Jin Chai, Huoshan, yellow grass, ring grass, horsewhip, wherein the most precious with dendrobium candidum.Iron The skin stem of noble dendrobium is mainly distributed on the countries and regions such as East Asia, Southeast Asia and Australia, China be mainly distributed on the Qinling Mountains, Huaihe River with Yunnan, Guangxi, Guizhou, the mountain area of zhejiang and other places in south.

In the present invention, the morphological feature of the dendrobium candidum is orchid family herbaceous plant.Stem is upright, cylinder, long 9-35 lis Rice, thick 2-4 millimeters, branch, does not have more piece, 1.3-1.7 centimetres of internode length, often in middle part 3-5 pieces of leaf of above alternate；Ye Erlie, Papery, long round shape lanceolar is long 3-7 centimetres, wide 9-15 millimeters, and tip is blunt and how many hook turn, the downward sheath to embrace stem of base portion, Edge and middle rib are often with lavender；Leaf sheath often has purple plague purpura, when old its upper limb and stem pine from and open, and leave 1 ring with section The ashen gap of shape.

Raceme is often sent from the old stem top for having fallen leaf, has 2-3 flower；Common peduncle is long 5-10 millimeters, base portion tool 2-3 Piece short sheath；Rachis inflection sigmoid, it is long 2-4 centimetres；Petal piece dry film matter, shallow white is avette, and long 5-7 millimeters, tip is slightly It is blunt；Bennet and ovary are long 2-2.5 centimetres；Sepal and petal yellow green, nearly similar, long round shape lanceolar are about 1.8 centimetres, wide 4-5 millimeters, the sharp point of tip has 5 arteries and veins；Side sepal base portion is broader, wide about 1 centimetre；Calyx capsule cone, is about 5 millimeters, end It is circular；Lip white, base portion has the corpus callosum of 1 green or yellow, and ovum shape lanceolar is more slightly shorter than sepal, middle part reflexed, tip Anxious point, does not split or unobvious 3 splits, and how much wavy the tool aubergine striped of both sides below middle part, edge is；Lip disk gathers thin papillary Hair, and 1 aubergine patch of tool more than middle part；Stamen post yellow green, is about 3 millimeters, tip both sides respectively have 1 purple point；Stamen Post foot yellow green band aubergine striped, thinly covered hair；Anther cap white, long ovate triangle is about 2.3 millimeters, the nearly sharp point in top is simultaneously And 2 split.Florescence 3-6 month.

Dendrobium candidum is the rare major class Chinese medicine of China's tradition, and applicating history is long,《Sheng Nong's herbal classic》(Christian era 25-220),《Compendium of Materia Medica》(1593 Christian eras) and《Chinese pharmacy dictionary》History tree ancient books and records such as (nineteen thirty-fives in Christian era) With《Pharmacopoeia of People's Republic of China》Each version it is on the books.In the Chinese Medicinal Materials Markets of China.Modern pharmacological research result Show that the effects such as dendrobium candidum has nourishing Yin and clearing heat, reinforcing stomach reg fluid moistening lung, cough-relieving, improvement digestive system is usually used in pyreticosis wound That Tianjin, dry polydipsia, deficiency of stomach-Yin, deficiency of food are retched, fire excess from yin deficiency, hectic fever due to yin labor heat, muscles and bones are withered is soft, abnormal heat, eyesight are weak etc. more after being ill Plant illness.

Dendrobium candidum is as one of " Chinese nine big celestial grass ", and main component is polysaccharide and alkaloid, containing a small amount of glucosides, The compounds such as luxuriant and rich with fragrance class, bibenzyl, its pharmacological action and alkaloid and polysaccharide close relation, mainly have it is anti-oxidant, antitumor, The effects such as antifatigue, hypoglycemic, raising immunity, protect liver and anti-gastric-ulcer.

Dendrobium candidum be mainly distributed on Anhui on the south the Qinling Mountains-Huaihe River, Jiangsu, Zhejiang, Hunan, Sichuan, Guizhou, Yunnan, The areas such as Guangxi, Jiangxi, Fujian and Guangdong, wherein being again many using Yunnan.Due to seed germination rate under dendrobium candidum natural conditions Low, wild remaining plant strain growth condition is harsh, current natural along with the deterioration of environment, and destruction, the excavation of the mankind for a long time Population of being survived in boundary seldom, extinction in imminent danger.

Dendrobium candidum is orchid family epiphyte, and habitat is unique, very strict to climate requirements.Plant is typically grown in sylvan life On the precipitous palisades in water side or ancient tree.Partially cloudy, with the humid air, nice and cool environment, drought-resistant and severe cold runs into accumulated snow freezing time In the longer age, it is withered that blade is withered and fallen or tip branch is endured cold.Generally with the mixed life of lichens, mosses and pteridophyte, constitute evergreen Ground storey.Plant catenary grows, and singly gives birth to or several plants grow thickly.It is born in Schattenseite, the half Schattenseite subacidity rock stratum of warm cool high humidity more On cliff, clustering distribution.On have forest side shading, under have Xi Gou water sources.Tailo or half tailo, domatic gentle ground are absolutely not given birth to It is long.It it is 8.5 DEG C~12.1 DEG C in year-round average temperature, the short-term low temperature of most cold -16 DEG C of the moon in winter remains to normal growth and survived the winter, not Suffer from cold evil.850~1100mm of annual precipitation, relative temperature 75% or so.Winter-spring season is slightly drought-resistant, but serious water shortage leaf often Slabbing is use up, and naked stem tides over poor environment, and branches and leaves are sprouted again to wet warm season section.It is typically distributed about below height above sea level 800m, highest sea Pull out 1350m.Often with the mixed life such as lichens, bryophyte and lepidogrammitis drymoglossoides Ching, volt stone fern, Selaginella tamariscina, stone beans orchid, surrounding forest has cork The seeds that the arbor stems of noble dendrobium such as oak, Qinggang oak, oriental white oak, Chinese ash and carpinus cardata are grown nonparasitically upon another plant are camphor tree, persimmon, Quercus acutissima, Chinese tallow tree, peach, pears, jujube, Pi Rake, yellowish-brown banyan etc..

Dendrobium candidum is rich in polysaccharide, dendrobine, free amino acid, vitamin (vitamin A, vitamin C, vitamin E), leaf Green plain and various enzymes, not only can also stop blooding by oral absorption, dendrobium candidum, promote wound healing, can be used to repair outside Multiple damaged oral.

Dendrobium candidum can make canker sore disease damage position obtain mechanical protection, strengthen anti-inflammatory and the reparation of Topical oral mucous membrane Ability, accelerates ulcer healing.By fresh dendrobium candidum chew it is rotten after spread on ulcer surface, ulcer healing, long term usage energy can be dramatically speeded up Prevent the generation of chamber ulcer, it is efficient up to more than 90%.《Cure the surplus justice of alcohol》Deng dendrobium candidum side《Root of kudzu vine Baihu Tang》、《Heat-clearing stomach Close and decoct》It is respectively provided with treatment toothache effect.By showing that dendrobium candidum is to periodontal to the customer survey for taking gloomy mountain dendrobium candidum Inflammation, canker sore, bleeding gums have good effect.

Wherein, Dendrobium officinale polysaccharide is rich in dendrobium candidum, there is Dendrobium officinale polysaccharide antibacterial, anti-inflammatory, enhancing cell to exempt from The function of epidemic disease activity, can suppress bacterial reproduction for oral cavity, effectively prevent oral peculiar smell；Dendrobium officinale polysaccharide external application can stop Blood, and fibrinous growth can be promoted, so as to promote wound healing, repair damaged oral tissue.Dendrobium candidum contains amino Acid and the various trace elements beneficial to human body, and the water-soluble polysaccharide included is a para-immunity reinforcing agent, can improve leucocyte, Lymphocyte is promoted to produce lymphokine, so as to strengthen humoral immunity of organism function, cellular immune function, enhancing body itself is exempted from Epidemic disease, promotes to recover.

The implantation methods of the dendrobium candidum grown nonparasitically upon another plant on strawberry tree are：Dendrobium candidum seedling is fixed on poplar with the rope made of hemp On Japanese apricot, the growth cycle of dendrobium candidum is 3 years.

The present inventor is found surprisingly that, the dendrobium candidum obtained on strawberry tree of growing nonparasitically upon another plant, its dendrobine and dendrobium polysaccharide Content and quality are greatly improved, and not only have extraordinary curative effect to canker sore, also to oral cavity dens in dente oulorrhagia, are removed Situations such as tartar, tooth whitening, has extraordinary repairing and treating effect.

In a preferred embodiment, the extracting method of the first dendrobium candidum extract is：By fresh iron The skin stem of noble dendrobium sequentially passes through cleaning, sterilization, crushed, and obtains dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately to In ethanol solution, at 15~30 DEG C, 1~5h of ultrasonic extraction is carried out, obtained solution is filtered, filtrate is through being concentrated under reduced pressure into nothing After ethanol, the first dendrobium candidum extract is obtained.

In a preferred embodiment, in the extracting method of the first dendrobium candidum extract, dendrobium officinale powder End, the weight ratio between chitosan are：(10~100)：1；More preferably, between the dendrobium candidum powder, chitosan Weight ratio be：(30~80)：1；Most preferably, the weight ratio between the dendrobium candidum powder, chitosan is：50：1.

In a preferred embodiment, in the ethanol solution, the volume ratio of ethanol and water is：1：(1~9)；Enter One step is preferably that the volume ratio of ethanol and water is：1：(3~7)；Most preferably, the volume ratio of ethanol and water is：1：4.

In a preferred embodiment, supersonic frequency used in the ultrasonic extraction is 30~100kHz；Enter one Step is preferably that supersonic frequency used in the ultrasonic extraction is 50~100kHz；Most preferably, the ultrasonic extraction is used Supersonic frequency be 80kHz.

In a preferred embodiment, the dendrobium candidum toothpaste with oral restoration function also includes the second iron Skin Herba Dendrobii extract；

The extracting method of the second dendrobium candidum extract is：

In a preferred embodiment, the weight between the dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar Than for 100：(1~8)：(0.1~1)：(3~15)：(0.5~3)；More preferably, the dendrobium candidum, the root of kudzu vine, gallop along on horseback Weight ratio between tire, pseudo-ginseng, Lombardy poplar is 100：(3~6)：(0.1~0.5)：(5~12)：(1~3)；Most preferably, institute It is 100 to state the weight ratio between dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar：4：0.3：10：2.

Term " root of kudzu vine ", also known as the numb rattan of kudzu, Pachyrhizua angulatus, dry Pueraria lobota, Pueraria lobota, are the root tuber of legume Pueraria lobota.Spring, autumn excavation, are washed Only, crust is removed, section is dried or dried.After the section of the rubbish such as Guangdong, Fujian, soaked with salt solution, alum water or rice washing water, then Dried after being smoked with Sulfur, color is more fair and more clear.

Chemical composition root of kudzu vine isoflavone-containing composition Puerarin, Puerarin xyloside, daizeol, daidzin and β-paddy Sterol, arachidic acid, again starch containing volume (in the fresh root of kudzu vine content be 19~20%).

Major function expelling pathogenic factors from muscles and skin is brought down a fever；Deliver and examine；Promote the production of body fluid to quench thirst；Shengyang Zhixie.Main fever caused by exogenous pathogens；Rigidity of nape and headache；Measles From the beginning of；Rash goes out not smooth；Warm disease is thirsty；Diabete；Diarrhea；Dysentery；Hypertension；Coronary heart disease etc..

Term " Giantleaf Ardisia Rhizome ", also known as big dispensing, laciniate blumea herb, mountain mouse, blood maple, mountain pig medicine.For Myrsinacea plant Giantleaf Ardisia Rhizome Rhizome.Autumn excavates, and cleans, and removes fibrous root, dries.

Major function wind-damp dispelling, strengthens the bone, promoting blood circulation.Control rheumatism arthralgia and myalgia, traumatic injury, postpartum blood stasis, ulcer Ulcer.

Term " pseudo-ginseng " also known as pseudo-ginseng, Yunnan seven, radix notoginseng, Radix Notoginseng, the present invention are mainly the dry root of pseudo-ginseng.

Major function dissipate stasis of blood hemostasis, detumescence ding-tong.For spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen Twinge, tumbling and swelling.

The root tuber of pseudo-ginseng is rich in arasaponin A, arasaponin B, and sapogenin A is generated respectively after the two hydrolysis, sapogenin B and One molecule glucose etc..

Term " Lombardy poplar ", alias Lombardy poplar, lombardy poplar, white poplar.

The chemical composition of Lombardy poplar is rich in rhamnetin and rhamnocitrin.Bud contains 3,3- dimethyl-allyls-trans- coffee Acid esters, 3,3- dimethyl-allyls-cis- caffeic acid ester, 3- iso-amylene-cis- caffeic acid ester, 3- iso-amylene-trans- caffeic acid ester.

Lombardy poplar major function removing pattogenic heat from the blood and toxic material from the body, dispelling wind and eliminating dampness.

The present inventor is found surprisingly that, the minimal amount of root of kudzu vine, Giantleaf Ardisia Rhizome, three are added in the second dendrobium candidum extract 7th, Lombardy poplar, can promote the dissolution of active ingredient, can repair canker sore while have it is extraordinary prevent treatment The situation of bleeding gums, similarly has extraordinary technique effect similarly for tooth whitening.

Bletilla striata extract

The bletilla striata, also known as Lian Jicao, Gan Gen, give free of charge, it is indocalamus orchid, Zhu Lan, purple blue, purple a species of orchid, hundred large bamboo hats with a conical crown and broad brim, Pseudobulbus Bletillae (Rhizoma Bletillae), Cold boiled chicken baby, white Root, YANGJIAOQI.

The bletilla striata is the dry tuber of orchid bletilla.Summer, season in autumn two excavation, remove fibrous root, clean, put boiled in boiling water or Steam to without the white heart, shining to half-dried, remove crust, dry.

The bletilla striata has 2~3 claw-like branches, long 1.5~5cm, 0.5~1.5cm of thickness more in irregular oblate.Surface ash White or yellow-white, there is a few concentric link and brown point-like marks of fibrous root, the stem trace for having projection above, there is another piece of connection below The vestige of stem.Matter is hard, is not easily broken, section off-white color, cutin sample.Odorless, bitter, what is chewed has stickiness.Bletilla striata bitter, it is sweet, It is puckery, it is slightly cold.Channel tropism return lung, liver, stomach.

Major function astringing to arrest bleeding, detumescence and promoting granulation.Spitted blood for hemoptysis, traumatism and bleeding, sore swollen toxin, chapped skin；Lung Tuberculosis hemoptysis, ulcer haemorrhage.

In a preferred embodiment, the extracting method of the bletilla striata extract is：The fresh bletilla striata is passed through successively Over cleaning, sterilization, crushing, obtain common bletilla；By common bletilla mass concentration for 10% sodium chloride solution in immersion 1~ 3h, then refrigerates 1h at -5 DEG C, obtains common bletilla solution；Common bletilla solution, chitosan are added separately to volume integral Number for 10% ethanol solutions in 1~2h of refluxing extraction, by obtained solution filter, filtrate after being concentrated under reduced pressure into no ethanol, Obtain bletilla striata extract.

The second aspect of the invention provides a kind of preparation method of the dendrobium candidum toothpaste with oral restoration function, At least comprise the following steps：

The dendrobium candidum toothpaste obtained by the formula and preparation method of the application toothpaste, is matched somebody with somebody using the uniqueness of dendrobium candidum Side, can improve oral environment, help canker sore healing；Capable of clearing heat and reducing internal heat, alleviates swelling and aching of gum；Healthy periodontal gum, prevention Bleeding gums；Fresh breath, removes removing abnormal flavor in oral cavity；Further, it is also possible to which tooth-whitening, Qinghuo Jiedu, inhibiting bacteria and diminishing inflammation, can effectively prevent Control the various oral inflammations such as sphagitis, canker sore, swelling and aching of gum.

The present invention is specifically described below by embodiment.It is necessarily pointed out that, following examples are only used In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.

In addition, if without other explanations, raw materials used is all commercially available, and number used in following material is weight Part.

Embodiment 1：

Embodiments of the invention 1 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

First 0.1 part of dendrobium candidum extract；1.0 parts of bletilla striata extract；15.0 parts of D-sorbite；8.0 parts of hydrated silica； 5.0 parts of glycerine；1.0 parts of borneol；1.0 parts of pearl shell powder；0.5 part of laruyl alcohol sodium sulfovinate；1.0 parts of polyethylene glycol 400；Xylose 0.5 part of alcohol；0.3 part of sodium carboxymethylcellulose；0.1 part of Chondrus crispus；0.1 part of xanthans；3.0 parts of saccharin sodium；C119140 1.0 part；1.0 parts of C142090；10 parts of water；

The extracting method of the first dendrobium candidum extract is：The fresh dendrobium candidums of 5g are sequentially passed through into cleaning, disappeared Poison, crushing, obtain dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately in 100ml ethanol solutions, 15 At DEG C, ultrasonic extraction 1h is carried out, obtained solution is filtered, filtrate obtains dendrobium candidum and carried after being concentrated under reduced pressure into no ethanol Take thing；Wherein, the weight ratio between dendrobium candidum powder, chitosan is 10：1；In the ethanol solution, the volume of ethanol and water Than for：1：1；Supersonic frequency used in the ultrasonic extraction is 30kHz；

The extracting method of the bletilla striata extract is：The fresh bletilla striatas of 3g are sequentially passed through into cleaning, sterilization, crushed, are obtained Common bletilla；Common bletilla is soaked into 1h in 5ml mass concentrations is 10% sodium chloride solutions, then refrigerated at -5 DEG C 1h, obtains common bletilla solution；Common bletilla solution, chitosan are added separately to the ethanol that 150ml volume fractions are 10% Refluxing extraction 1h in solution, obtained solution is filtered, and filtrate obtains bletilla striata extract after being concentrated under reduced pressure into no ethanol；Its In, the weight ratio between common bletilla, chitosan is 20：1；Supersonic frequency used in the ultrasonic extraction is 100kHz.

The preparation technology of dendrobium candidum toothpaste with oral restoration function, comprises the following steps：

Each component is weighed by weight, by D-sorbite, hydrated silica, glycerine, borneol, pearl shell powder, laruyl alcohol sulfuric acid After ester sodium, Chondrus crispus, xanthans and water mixing, homogeneous stirring is carried out under 100 DEG C of constant temperature, mixing time is After 15 minutes, then into system add polyethylene glycol, xylitol, sodium carboxymethylcellulose, xanthans, saccharin sodium, C119140, C142090, then system be warming up to 110 DEG C, mixing time is 15 minutes；Then system temperature is down to 40 DEG C, be separately added into First dendrobium candidum extract, bletilla striata extract, are again stirring for after 30 minutes being cooled to 25 DEG C rapidly, and at 25 DEG C, ageing 5h, obtains the dendrobium candidum toothpaste with oral restoration function.

Embodiment 2：

Embodiments of the invention 2 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

First 1.0 parts of dendrobium candidum extract；10 parts of bletilla striata extract；35.0 parts of D-sorbite；25.0 parts of hydrated silica； 12.0 parts of glycerine；3.0 parts of borneol；6.0 parts of pearl shell powder；3.0 parts of laruyl alcohol sodium sulfovinate；10.0 parts of polyethylene glycol；Xylitol 3.0 part；1.0 parts of sodium carboxymethylcellulose；1.0 parts of Chondrus crispus；1.0 parts of xanthans；8.0 parts of saccharin sodium；C119140 3.0 Part；3.0 parts of C142090；40 parts of water；

Embodiment 3：

Embodiments of the invention 3 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

First 0.5 part of dendrobium candidum extract；3 parts of bletilla striata extract；20.0 parts of D-sorbite；15.0 parts of hydrated silica； 8.0 parts of glycerine；1.0 parts of borneol；3.0 parts of pearl shell powder；1.0 parts of laruyl alcohol sodium sulfovinate；3.0 parts of polyethylene glycol；Xylitol 1.0 Part；0.5 part of sodium carboxymethylcellulose；0.3 part of Chondrus crispus；0.5 part of xanthans；4.0 parts of saccharin sodium；1.5 parts of C119140； 2.0 parts of C142090；20 parts of water；

Embodiment 4：

Embodiments of the invention 4 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

First 0.8 part of dendrobium candidum extract；8 parts of bletilla striata extract；30.0 parts of D-sorbite；20.0 parts of hydrated silica； 10.0 parts of glycerine；3.0 parts of borneol；5.0 parts of pearl shell powder；2.5 parts of laruyl alcohol sodium sulfovinate；10.0 parts of polyethylene glycol；Xylitol 2.5 part；1.0 parts of sodium carboxymethylcellulose；0.8 part of Chondrus crispus；1.0 parts of xanthans；6.0 parts of saccharin sodium；C119140 3.0 Part；3.0 parts of C142090；35 parts of water；

Embodiment 5：

Embodiments of the invention 5 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

Embodiment 6：

Embodiments of the invention 6 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

The extracting method of the first dendrobium candidum extract is：The fresh dendrobium candidums of 5g are sequentially passed through into cleaning, disappeared Poison, crushing, obtain dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately in 100ml ethanol solutions, 15 At DEG C, ultrasonic extraction 1h is carried out, obtained solution is filtered, filtrate obtains dendrobium candidum and carried after being concentrated under reduced pressure into no ethanol Take thing；Wherein, the weight ratio between dendrobium candidum powder, chitosan is 100：1；In the ethanol solution, the body of ethanol and water Accumulating ratio is：1：9；Supersonic frequency used in the ultrasonic extraction is 100kHz；

Embodiment 7：

Embodiments of the invention 7 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

The extracting method of the first dendrobium candidum extract is：The fresh dendrobium candidums of 5g are sequentially passed through into cleaning, disappeared Poison, crushing, obtain dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately in 100ml ethanol solutions, 15 At DEG C, ultrasonic extraction 1h is carried out, obtained solution is filtered, filtrate obtains dendrobium candidum and carried after being concentrated under reduced pressure into no ethanol Take thing；Wherein, the weight ratio between dendrobium candidum powder, chitosan is 80：1；In the ethanol solution, the volume of ethanol and water Than for：1：4；Supersonic frequency used in the ultrasonic extraction is 80kHz；

The extracting method of the bletilla striata extract is：The fresh bletilla striatas of 3g are sequentially passed through into cleaning, sterilization, crushed, are obtained Common bletilla；Common bletilla is soaked into 1h in 5ml mass concentrations is 10% sodium chloride solutions, then refrigerated at -5 DEG C 1h, obtains common bletilla solution；Common bletilla solution, chitosan are added separately to the ethanol that 150ml volume fractions are 10% Refluxing extraction 1h in solution, obtained solution is filtered, and filtrate obtains bletilla striata extract after being concentrated under reduced pressure into no ethanol；Its In, the weight ratio between common bletilla, chitosan is 100：1；Supersonic frequency used in the ultrasonic extraction is 100kHz.

Embodiment 8：

Embodiments of the invention 8 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

The dendrobium candidum is the dendrobium candidum extract grown nonparasitically upon another plant on strawberry tree.

Embodiment 9：

Embodiments of the invention 9 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, bag Include following components：

First 0.5 part of dendrobium candidum extract；7 parts of bletilla striata extract；25.0 parts of D-sorbite；18.0 parts of hydrated silica； 9.0 parts of glycerine；2.0 parts of borneol；4.0 parts of pearl shell powder；2.0 parts of laruyl alcohol sodium sulfovinate；8.0 parts of polyethylene glycol；Xylitol 2.0 Part；1.0 parts of sodium carboxymethylcellulose；0.5 part of Chondrus crispus；1.0 parts of xanthans；5.0 parts of saccharin sodium；2.0 parts of C119140； 3.0 parts of C142090；30 parts of water, 1 part of the second dendrobium candidum extract；

The extracting method of the second dendrobium candidum extract is：

The mixture of dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar is ground to form into mix powder, mix powder Gross weight be 10g, mix powder is added to 200ml volume fractions in 20% ethanol solution, at 40 DEG C, to be surpassed Sound extracts 1h, and obtained solution is filtered, and filtrate obtains the second dendrobium candidum extract after being concentrated under reduced pressure into no ethanol.

Weight ratio between dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar is 100：1：0.1：3：0.5；

The Lombardy poplar is selected from Lombardy poplar bark；

Each component is weighed by weight, by D-sorbite, hydrated silica, glycerine, borneol, pearl shell powder, laruyl alcohol sulfuric acid After ester sodium, Chondrus crispus, xanthans and water mixing, homogeneous stirring is carried out under 100 DEG C of constant temperature, mixing time is After 30 minutes, then into system add polyethylene glycol, xylitol, sodium carboxymethylcellulose, xanthans, saccharin sodium, C119140, C142090, then system be warming up to 110 DEG C, mixing time is 15 minutes；Then system temperature is down to 40 DEG C, be separately added into First dendrobium candidum extract, the second dendrobium candidum extract, bletilla striata extract, are again stirring for after 30 minutes being cooled to 25 rapidly DEG C, and at 25 DEG C, be aged 5h, obtain the dendrobium candidum toothpaste with oral restoration function.

Embodiment 10：

Embodiments of the invention 10 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, Including following components：

First 0.5 part of dendrobium candidum extract；7 parts of bletilla striata extract；25.0 parts of D-sorbite；18.0 parts of hydrated silica； 9.0 parts of glycerine；2.0 parts of borneol；4.0 parts of pearl shell powder；2.0 parts of laruyl alcohol sodium sulfovinate；8.0 parts of polyethylene glycol；Xylitol 2.0 Part；1.0 parts of sodium carboxymethylcellulose；0.5 part of Chondrus crispus；1.0 parts of xanthans；5.0 parts of saccharin sodium；2.0 parts of C119140； 3.0 parts of C142090；30 parts of water, 0.5 part of the second dendrobium candidum extract；

The first dendrobium candidum extract, bletilla striata extract, the second dendrobium candidum extract be the same as Example 9, difference It is, the weight ratio between dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar is 100：1：0.1：3：0.5；

Embodiment 11：

Embodiments of the invention 11 provide a kind of dendrobium candidum toothpaste with oral restoration function, in parts by weight, Including following components：

First 0.5 part of dendrobium candidum extract；7 parts of bletilla striata extract；25.0 parts of D-sorbite；18.0 parts of hydrated silica； 9.0 parts of glycerine；2.0 parts of borneol；4.0 parts of pearl shell powder；2.0 parts of laruyl alcohol sodium sulfovinate；8.0 parts of polyethylene glycol；Xylitol 2.0 Part；1.0 parts of sodium carboxymethylcellulose；0.5 part of Chondrus crispus；1.0 parts of xanthans；5.0 parts of saccharin sodium；2.0 parts of C119140； 3.0 parts of C142090；30 parts of water, 2 parts of the second dendrobium candidum extract；

The first dendrobium candidum extract, bletilla striata extract, the second dendrobium candidum extract be the same as Example 9, difference It is, the weight ratio between dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar is 100：4：0.3：10：2；

Comparative example 1：

The be the same as Example 11 of comparative example 1 of the present invention, difference is, in the second dendrobium candidum extract, does not include Dendrobium candidum.

Comparative example 2：

The be the same as Example 11 of comparative example 2 of the present invention, difference is, in the second dendrobium candidum extract, does not include Giantleaf Ardisia Rhizome.

Comparative example 3：

The be the same as Example 11 of comparative example 3 of the present invention, difference is, in the second dendrobium candidum extract, does not include Lombardy poplar.

Comparative example 4：

The be the same as Example 11 of comparative example 4 of the present invention, difference is, in the second dendrobium candidum extract, does not include Giantleaf Ardisia Rhizome, Lombardy poplar.

Performance test

1st, dental ulcer treatment effect：220 canker sore patients are chosen as experimental subjects, wherein man 120, female 100, between one full year of life at age 18~72,220 canker sore patients are randomly divided into 11 groups, every group of 20 people, respectively using reality Apply the stem of noble dendrobium toothpaste obtained in 1~embodiment of example 11 2 days, it is early, middle and late respectively once, after 2 days to observe whether canker sore fully recovers.

2nd, bleeding gums therapeutic effect：220 bleeding gums patients are chosen as experimental subjects, wherein man 110, female 110, between one full year of life at age 8~72,220 bleeding gums patients are randomly divided into 11 groups, every group of 20 people, respectively using implementing The stem of noble dendrobium toothpaste obtained in 1~embodiment of example 11, observation uses how many times stem of noble dendrobium toothpaste, can cure bleeding gums.

3rd, calculus dentalis removal effect：220 Severe calculus patients are chosen as experimental subjects, wherein man 150, female 70 Between example, one full year of life at age 18~72,220 calculus dentalis patients are randomly divided into 11 groups, every group of 20 people, respectively using embodiment 1 The stem of noble dendrobium toothpaste obtained in~embodiment 11, usage cycles are 1 week, observe therapeutic effect：It is effective, effective, invalid, wherein, show Imitate and be：Calculus dentalis is all removed；Effectively it is：Calculus dentalis part is removed；It is invalid all not removed a little for calculus dentalis.

The performance test table of table 1

Embodiment	Dental ulcer treatment	Bleeding gums/number of times	Calculus dentalis removal effect
				Embodiment 1	Recovery from illness	15	Effectively
Embodiment 2	Recovery from illness	15	Effectively
				Embodiment 3	Recovery from illness	13	Effectively
Embodiment 4	Recovery from illness	14	Effectively
				Embodiment 5	Recovery from illness	13	Effectively
Embodiment 6	Recovery from illness	12	Effectively
				Embodiment 7	Recovery from illness	12	Effectively
Embodiment 8	Recovery from illness	6	It is effective
				Embodiment 9	Recovery from illness	2	It is effective
Embodiment 10	Recovery from illness	2	It is effective
				Embodiment 11	Recovery from illness	1	It is effective
Comparative example 1	Recovery from illness	28	Effectively
				Comparative example 2	Recovery from illness	39	Effectively
Comparative example 3	Recovery from illness	42	Effectively
				Comparative example 4	Recovery from illness	68	It is invalid

Product it can be seen from upper table 1 in the present invention has very for canker sore, bleeding gums, calculus dentalis removal Good therapeutic effect, the present inventor is found surprisingly that, by the extract for the dendrobium candidum on strawberry tree of growing nonparasitically upon another plant, for oral cavity The healing of ulcer has extraordinary technique effect.

Foregoing example is merely illustrative, some features for explaining the method for the invention.Appended right will The scope as wide as possible for being intended to require to be contemplated that is sought, and embodiments as presented herein is implemented according to all possible The explanation of the embodiment of the selection of the combination of example.Therefore, the purpose of applicant is that appended claim is not illustrated this hair The selectional restriction of the example of bright feature.Some number ranges used also include sub- model within the claims Enclose, the change in these scopes should be also construed to by appended claim covering in the conceived case.

Claims

1. a kind of dendrobium candidum toothpaste with oral restoration function, it is characterised in that in parts by weight, at least including with the following group Point：

First 0.1~1.0 part of dendrobium candidum extract；1.0~10 parts of bletilla striata extract；15.0~35.0 parts of D-sorbite；Water Close 8.0~25.0 parts of silica；5.0~12.0 parts of glycerine；1.0~3.0 parts of borneol；1.0~6.0 parts of pearl shell powder；Laruyl alcohol sulphur 0.5~3.0 part of acid esters sodium；1.0~10.0 parts of polyethylene glycol；0.5~3.0 part of xylitol；Sodium carboxymethylcellulose 0.3~1.0 Part；0.1~1.0 part of Chondrus crispus；0.1~1.0 part of xanthans；3.0~8.0 parts of saccharin sodium；1.0~3.0 parts of C119140； 1.0~3.0 parts of C142090；10~40 parts of water；

The extracting method of the first dendrobium candidum extract is：Fresh dendrobium candidum is sequentially passed through into cleaning, sterilization, powder It is broken, obtain dendrobium candidum powder；Dendrobium candidum powder, chitosan are added separately in ethanol solution, at 15~30 DEG C, entered Row 1~5h of ultrasonic extraction, obtained solution is filtered, and filtrate obtains the first dendrobium candidum and carried after being concentrated under reduced pressure into no ethanol Take thing；

The extracting method of the bletilla striata extract is：The fresh bletilla striata is sequentially passed through into cleaning, sterilization, crushed, bletilla striata powder is obtained End；Common bletilla is soaked into 1~3h in mass concentration is 10% sodium chloride solution, then 1h is refrigerated at -5 DEG C, obtains Common bletilla solution；Common bletilla solution, chitosan are added separately to flow back in the ethanol solution that volume fraction is 10% and carried 1~2h is taken, obtained solution is filtered, filtrate obtains bletilla striata extract after being concentrated under reduced pressure into no ethanol.

2. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that in parts by weight, At least include following components：

First 0.5~0.8 part of dendrobium candidum extract；3~8 parts of bletilla striata extract；20.0~30.0 parts of D-sorbite；It is hydrated silicon 15.0~20.0 parts of stone；8.0~10.0 parts of glycerine；1.0~3.0 parts of borneol；3.0~5.0 parts of pearl shell powder；Bay alcohol sulfuric ester 1.0~2.5 parts of sodium；3.0~10.0 parts of polyethylene glycol；1.0~2.5 parts of xylitol；0.5~1.0 part of sodium carboxymethylcellulose；Wrinkle 0.3~0.8 part of ripple Irish moss；0.5~1.0 part of xanthans；4.0~6.0 parts of saccharin sodium；1.5~3.0 parts of C119140； 2.0~3.0 parts of C142090；20~35 parts of water；

3. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 2, it is characterised in that in parts by weight, At least include following components：

First 0.5 part of dendrobium candidum extract；7 parts of bletilla striata extract；25.0 parts of D-sorbite；18.0 parts of hydrated silica；Glycerine 9.0 part；2.0 parts of borneol；4.0 parts of pearl shell powder；2.0 parts of laruyl alcohol sodium sulfovinate；8.0 parts of polyethylene glycol；2.0 parts of xylitol； 1.0 parts of sodium carboxymethylcellulose；0.5 part of Chondrus crispus；1.0 parts of xanthans；5.0 parts of saccharin sodium；2.0 parts of C119140； 3.0 parts of C142090；30 parts of water；

4. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that first iron sheet In the extracting method of Herba Dendrobii extract, the weight ratio between dendrobium candidum powder, chitosan is：(10~100)：1.

5. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that first iron sheet In the extracting method of Herba Dendrobii extract, the volume ratio of ethanol and water is：1：(1~9).

6. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that the dendrobium candidum For the dendrobium candidum on strawberry tree of growing nonparasitically upon another plant.

7. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that the ultrasonic extraction Used supersonic frequency is 30~100kHz.

8. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 1, it is characterised in that described that there is oral cavity The dendrobium candidum toothpaste of repair function also includes the second dendrobium candidum extract；

The extracting method of the second dendrobium candidum extract is：

By dendrobium candidum, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar mixture, mix powder is ground to form, by mix powder Volume fraction is added in 20% ethanol solution, at 20~40 DEG C, 1~5h of ultrasonic extraction to be carried out, by obtained solution mistake Filter, filtrate obtains the second dendrobium candidum extract after being concentrated under reduced pressure into no ethanol.

9. there is the dendrobium candidum toothpaste of oral restoration function as claimed in claim 8, it is characterised in that the iron sheet stone Weight ratio between dry measure used in former times, the root of kudzu vine, Giantleaf Ardisia Rhizome, pseudo-ginseng, Lombardy poplar is 100：(1~8)：(0.1~1)：(3~15)：(0.5~3).

10. the preparation technology of the dendrobium candidum toothpaste with oral restoration function as described in claim 1~7, its feature exists In at least comprising the following steps：

Weigh each component by weight, by D-sorbite, hydrated silica, glycerine, borneol, pearl shell powder, laruyl alcohol sodium sulfovinate, After Chondrus crispus, xanthans and water mixing, homogeneous stirring is carried out under 70~100 DEG C of constant temperature, mixing time is After 15~30 minutes, then into system add polyethylene glycol, xylitol, sodium carboxymethylcellulose, xanthans, saccharin sodium, C119140, C142090, then system be warming up to 110~150 DEG C, mixing time is 15~60 minutes；Then by system temperature 40~60 DEG C are down to, the first dendrobium candidum extract, bletilla striata extract is separately added into, is cooled to rapidly after being again stirring for 30 minutes 25~26 DEG C, and at 25~30 DEG C, be aged 5h, obtain the dendrobium candidum toothpaste with oral restoration function.