CN110090188A - A kind of Chinese medicinal toothpaste and preparation method thereof - Google Patents
A kind of Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN110090188A CN110090188A CN201910377965.5A CN201910377965A CN110090188A CN 110090188 A CN110090188 A CN 110090188A CN 201910377965 A CN201910377965 A CN 201910377965A CN 110090188 A CN110090188 A CN 110090188A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of Chinese medicinal toothpastes and preparation method thereof, toothpaste includes the raw material of following mass percentage: Chinese medicine extract 5%-80%, saccharin 0.1%-0.5%, sodium benzoate 0.3-1%, sorbierite 5%-20%, glycerol 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-10%, essence 0.2%, preparation method is: cloves, the bletilla striata, American Ginseng and dendrobium nobile are extracted in advance；It is finally extracted with ethanol solution again；Extracting solution in step 2 is concentrated, and removes ethyl alcohol；Solution obtained in step 3 is subjected to high speed centrifugation；Chinese medicine extract 5%-80% and other raw materials in step 4 is taken to be sufficiently mixed；By the mixed liquor in step 5 by homogenizer homogeneous, lotion of toothpaste is obtained.The present invention realizes the balance in oral health between beneficial bacterium and harmful bacteria, and oral lesion and oral mucosa repair the balance between power, inhibits oral cavity pathogen by herbal essence, while promoting oral cavity beneficial bacterium function, and enhancing oral mucosa repair ability.
Description
Technical field
The present invention relates to oral cleaning nursing article technical field, specifically a kind of Chinese medicinal toothpaste and preparation method thereof.
Background technique
Daytime normal oral cavity activity, salivary secretion amount is more, reduces the accumulation of bacterium and swill in oral cavity；And oxygen
Gas concentration is high, and pH value is normal, and anaerobic bacteria is in holddown.And in night oral cavity salivary secretion amount reduce, oral cavity it is self-cleaning
It acts on low；Oxygen concentration relative reduction, anaerobic bacteria is able to mass propagation, and anoxic reduces the amount of blood supply of periodontium,
It causes to be conducive to noxious material for hypoxgia and accumulate, so as to cause under the defence capability of periodontal, antibacterial ability and repair ability
Drop；PH value reduces, and provides advantage for the growth of plaque, and plaque mainly causes biggish harm to tooth and gum,
It will lead to the generation of common dental caries and periodontosis again.Furthermore some habits that people form in daily life as inhaled for a long time
Cigarette has tea, drinks coffee, eating of the deeper food of color so that be attached to dental surface plaque and swill it is mutual
Calcification forms tooth stain after effect, and tooth stain not only influences the beauty of tooth, and can damage tooth and gum, cause tooth mobility with
And gum disease.Evening clothing shield gum toothpaste is designed and developed for these problems, can effectively solve the difference due to morning and evening oral environment
And the oral problems such as plaque, calculus dentalis, periodontosis, saprodontia, tooth stain generated.
Cloves has inhibiting effect in 1:8000-1:16000, to pathogenic fungus.When decoction 1:20-1:640 concentration,
There are inhibiting effect, caryophyllus oil and fourth to the bacillus such as staphylococcus, streptococcus and diphtheria, deformation, green pus, large intestine, dysentery, typhoid fever
Sesame oil phenol is in 1:2000-1:8000 concentration, to staphylococcus aureus and pneumonia, dysentery (shiga), large intestine, deformation, knot
The bacillus such as core have bacteriostasis.Show cloves petroleum ether extract from mouse hot-plate test and antitorque precursor reactant test result
It is latent that (0.15ml/kg and 0.3ml/kg) and cloves water extract (10g/kg and 20g/kg) can dramatically extension mouse pain sensation reaction
Writhing caused by phase and significant reduction mouse stimulate because of glacial acetic acid 0.1ml/10g, reaction times.
Bletilla polysaccharide is likely to become a kind of novel Chinese medicine caries preventive agent.To several frequently seen epidermal skin pathogenic bacteria, use is white
Splendid achnatherum extract has carried out bacteriostatic test, is coated on 30 DEG C of constant temperature incubations using direct plate to the bacteriostatic test of mould, saccharomycete.
37 DEG C of constant temperature incubations are incubated at using tube dilution to the bacteriostatic test of bacterium, as the result is shown: bletilla striata mucopolysaccharide is for most easily invading
The staphylococcus aureus and acrothesium floccosum for contaminating application on human skin have extremely strong antibacterial action, to Candida albicans and gypsum sample tinea
Bacterium also has stronger antibacterial action.It is measured using disk diffusion method, concentration occurs antibacterial in the bletilla polysaccharide of 125mg/L or more
Circle.The inhibition zone that the bletilla striata mucopolysaccharide solution of various concentration generates is of different sizes.Bletilla striata concentration proportional relation approximate with inhibition zone,
Statistical analysis, P < 0.01.It is measured through liquid dilution method, bletilla striata mucopolysaccharide solution is to the minimum inhibitory concentration of streptococcus mutans
125mg/L。
American Ginseng enriching yin boost qi can promote human body to generate and secrete various antibody, complement, neutrocyte and bacteriolyze
A variety of antimicrobial factors such as enzyme, lactoferrin limit the undue growth of local pathogenic microorganisms；American Ginseng can promote oral cavity simultaneously
The microcirculation of part promotes the growth of canker sore local mucous membrane.
Dendrobium nobile, traditional Chinese medicine thinks, the Oral symptoms such as periodontitis, bleeding gums, canker sore, mostly flaring up of heart fire and lung stomach
Excess heat, lung stomach gas from mouth go out and cause.Because stress, dehydration, infection, fever etc., show as that endogenous fire void is prosperous, and body fluid deficiency more.Iron
Skin dendrobium nobile promotes the recovery of patient by nourishing Yin and clearing heat, reinforcing stomach reg fluid.Modern drug efficacy study proves: dendrobium candidum contains amino
Acid and the various trace elements beneficial to human body, and the water-soluble polysaccharide included is a kind of immunopotentiator, and leucocyte can be improved,
Promote lymphocyte to generate lymphokine, to enhance humoral immunity of organism function, cellular immune function, enhances body itself
It is immune, promote to restore.Experiment shows, can be formed and be protected in skin surface after the canker sore surface of a wound is applied with dendrobium candidum particle
Film keeps the higher drug concentration in part, and lesion is made to obtain mechanical protection, enhances the anti-inflammatory of Topical oral mucous membrane and repairs
Reactivation power, accelerates ulcer healing.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicinal toothpastes and preparation method thereof, to solve to propose in above-mentioned background technique
The problem of.
To achieve the above object, the invention provides the following technical scheme:
A kind of Chinese medicinal toothpaste, the raw material including following mass percentage: Chinese medicine extract 5%-80%, saccharin 0.1%-
0.5%, sodium benzoate 0.3-1%, sorbierite 5%-20%, glycerol 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-
10%, essence 0.2%, deionized water are surplus, and the summation of above-mentioned each component is 100%.
As a further solution of the present invention: the Chinese medicine extract is the extraction of cloves, the bletilla striata, American Ginseng and dendrobium nobile
Liquid.
As a further solution of the present invention: the essence is peppermint.
As a further solution of the present invention: the pulvis is silica.
A kind of preparation method of Chinese medicinal toothpaste, includes the following steps:
One, cloves, the bletilla striata, American Ginseng and dendrobium nobile are extracted in advance with ten times of medicinal material weight of deionized water；
Two, the medicinal material in step 2 is finally extracted with 5 times of its weight of ethanol solution again；
Three, the extracting solution in step 2 is concentrated, and removes ethyl alcohol；
Four, solution obtained in step 3 is subjected to high speed centrifugation, obtains supernatant and is saved；
Five, Chinese medicine extract 5%-80%, saccharin 0.1%-0.5%, the sodium benzoate 0.3-1%, mountain in step 4 are taken
Pears alcohol 5%-20%, glycerol 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-10% and essence 0.2% are sufficiently mixed
It closes；
Six, the mixed liquor in step 5 is obtained into lotion of toothpaste by homogenizer homogeneous 20-60min.
As a further solution of the present invention: in step 2, the concentration of the ethanol solution is 70%.
Compared with prior art, the beneficial effects of the present invention are:
A kind of heretofore described Chinese medicinal toothpaste, realizes the balance in oral health between beneficial bacterium and harmful bacteria, mouth
Chamber damage and oral mucosa repair the balance between power, inhibit oral cavity pathogen by herbal essence, while promoting oral cavity beneficial
Bacterium function, and enhancing oral mucosa repair ability, the antibacterial efficiency factor includes: eugenol, syringone, bletilla polysaccharide etc.,
The reparation efficiency factor includes: bletilla polysaccharide, dendrobium polysaccharide, American ginseng saponin, bletilla polysaccharide etc..
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the present invention is clearly and completely described, it is clear that
Described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the implementation in the present invention
Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to
The scope of protection of the invention.
In the embodiment of the present invention, a kind of Chinese medicinal toothpaste, the raw material including following mass percentage: cloves, the bletilla striata, the West
Ginseng and dendrobium nobile medicament extracting solution 5%-80%, saccharin 0.1%-0.5%, sodium benzoate 0.3-1%, sorbierite 5%-20%, glycerol
2%-5%, xanthan gum 0.5%-2.5%, silica 2%-10%, peppermint 0.2%, deionized water are surplus, above-mentioned each group
The summation divided is 100%.
A kind of preparation method of Chinese medicinal toothpaste, includes the following steps:
One, cloves, the bletilla striata, American Ginseng and dendrobium nobile are extracted in advance with ten times of medicinal material weight of deionized water；
Two, the medicinal material in step 2 is finally extracted with 5 times of its weight of 70% concentration ethanol solution again；
Three, the extracting solution in step 2 is concentrated, and removes ethyl alcohol；
Four, solution obtained in step 3 is subjected to high speed centrifugation, obtains supernatant and is saved；
Five, Chinese medicine extract 5%-80%, saccharin 0.1%-0.5%, the sodium benzoate 0.3-1%, mountain in step 4 are taken
Pears alcohol 5%-20%, glycerol 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-10% and essence 0.2% are sufficiently mixed
It closes；
Six, the mixed liquor in step 5 is obtained into lotion of toothpaste by homogenizer homogeneous 20-60min.
1, experiment reagent and method:
Test selected toothpaste: Crest toothpaste, experiment toothpaste.
Oral cavity common bacteria: streptococcus mutans (s.mutants) and Candida albicans (C.albicans), the compound strain of bacterium
It is provided by the western base experimental center of preclinical medicine institute.
Detecting instrument: microorganism rapid fluorescence detector (U.S. BioLumix)
Grouping: bacterium is added in blank group (kongbai), detection pipe, is added without toothpaste, and the life with toothpaste same volume is added
Salt water 1ml is managed, the incubation of microorganism rapid fluorescence detector is placed in.
Crest group: (jiajishi0711) weighs 1g Crest toothpaste, is added 5ml physiological saline, after ultrasonic 10min
Centrifuging and taking supernatant 1ml is added detection pipe, adds bacterium, is placed in the incubation of microorganism rapid fluorescence detector.
Experimental group: Crest toothpaste is changed to No. 238 toothpaste that experiment is developed, remaining operation is identical.
2, experimental result
After being incubated for 12.6 hours, fluorescent value rises to blank group, illustrates that amount of bacteria obviously increases；Crest group is being incubated for
After 31.7 hours, fluorescent value is risen to, and illustrates compared to the blank group, the bacterium time to be inhibited to have 15 hours；Experimental group is small in incubation 48
When it is interior, fluorescent value illustrates that fungistatic effect is ideal without rising to.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (6)
1. a kind of Chinese medicinal toothpaste, which is characterized in that the raw material including following mass percentage: Chinese medicine extract 5%-80%, sugar
Smart 0.1%-0.5%, sodium benzoate 0.3-1%, sorbierite 5%-20%, glycerol 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-10%,
Essence 0.2%, deionized water are surplus, and the summation of above-mentioned each component is 100%.
2. a kind of Chinese medicinal toothpaste according to claim 1 and preparation method thereof, which is characterized in that the Chinese medicine extract is
Cloves, the bletilla striata, American Ginseng and dendrobium nobile extracting solution.
3. a kind of Chinese medicinal toothpaste according to claim 1 and preparation method thereof, which is characterized in that the essence is peppermint.
4. a kind of Chinese medicinal toothpaste according to claim 1 and preparation method thereof, which is characterized in that the pulvis is titanium dioxide
Silicon.
5. a kind of preparation method of Chinese medicinal toothpaste as defined in claim 1, includes the following steps:
Cloves, the bletilla striata, American Ginseng and dendrobium nobile are extracted in advance with ten times of medicinal material weight of deionized water；
The medicinal material in step 2 is finally extracted with 5 times of its weight of ethanol solution again；
Extracting solution in step 2 is concentrated, and removes ethyl alcohol；
Solution obtained in step 3 is subjected to high speed centrifugation, supernatant is obtained and is saved；
Take Chinese medicine extract 5%-80% in step 4, saccharin 0.1%-0.5%, sodium benzoate 0.3-1%, sorbierite 5%-20%, sweet
Oily 2%-5%, xanthan gum 0.5%-2.5%, pulvis 2%-10% and essence 0.2% are sufficiently mixed；
By the mixed liquor in step 5 by homogenizer homogeneous 20-60min, that is, obtain lotion of toothpaste.
6. a kind of preparation method of Chinese medicinal toothpaste according to claim 5, which is characterized in that in step 2, the second
The concentration of alcoholic solution is 70%.
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| CN201910377965.5A CN110090188A (en) | 2019-05-08 | 2019-05-08 | A kind of Chinese medicinal toothpaste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972290A (en) * | 2021-03-16 | 2021-06-18 | 江苏雪豹日化有限公司 | Biological lysozyme composition for dental plaque |
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|---|---|---|---|---|
| CN101380285A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Bletilla striata Chinese herbal medicine toothpaste |
| CN104324062A (en) * | 2014-11-26 | 2015-02-04 | 任贵兴 | American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application |
| CN105943478A (en) * | 2016-05-10 | 2016-09-21 | 芜湖亮晶晶生物科技有限公司 | Toothpaste with efficacies of brightening and whitening teeth and diminishing inflammation and preparation method of toothpaste |
| CN107028850A (en) * | 2017-04-24 | 2017-08-11 | 上海玉慈生物科技有限公司 | Dendrobium candidum toothpaste and its preparation technology with oral restoration function |
| CN107320428A (en) * | 2017-07-17 | 2017-11-07 | 金日制药（中国）有限公司 | A kind of toothpaste for being used to balance Oral health behaviours |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
-
2019
- 2019-05-08 CN CN201910377965.5A patent/CN110090188A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380285A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Bletilla striata Chinese herbal medicine toothpaste |
| CN104324062A (en) * | 2014-11-26 | 2015-02-04 | 任贵兴 | American ginseng conversion saponin, traditional Chinese medicine mouth care composition thereof and preparation method and application |
| CN105943478A (en) * | 2016-05-10 | 2016-09-21 | 芜湖亮晶晶生物科技有限公司 | Toothpaste with efficacies of brightening and whitening teeth and diminishing inflammation and preparation method of toothpaste |
| CN107028850A (en) * | 2017-04-24 | 2017-08-11 | 上海玉慈生物科技有限公司 | Dendrobium candidum toothpaste and its preparation technology with oral restoration function |
| CN107320428A (en) * | 2017-07-17 | 2017-11-07 | 金日制药（中国）有限公司 | A kind of toothpaste for being used to balance Oral health behaviours |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972290A (en) * | 2021-03-16 | 2021-06-18 | 江苏雪豹日化有限公司 | Biological lysozyme composition for dental plaque |
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Application publication date: 20190806 |