CN101380285A - Bletilla striata Chinese herbal medicine toothpaste - Google Patents
Bletilla striata Chinese herbal medicine toothpaste Download PDFInfo
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- CN101380285A CN101380285A CNA2008101571989A CN200810157198A CN101380285A CN 101380285 A CN101380285 A CN 101380285A CN A2008101571989 A CNA2008101571989 A CN A2008101571989A CN 200810157198 A CN200810157198 A CN 200810157198A CN 101380285 A CN101380285 A CN 101380285A
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Abstract
The invention pertains to the field of daily chemical industry and discloses a Chinese herbal toothpaste made from bletilla striata. The Chinese herbal toothpaste made from bletilla striata contains a toothpaste matrix which comprises paeonol and bletilla striata or the bletilla striata polysaccharide. The toothpaste has the functions of antibiosis, anti-inflammation, promotion of wound healing, hemostasis and the like, therefore, the toothpaste can be applied to preventing and treating oral diseases and dental diseases such as ulcerative stomatitis, throat irritation, periodontitis, gingivitis, dental caries, oral malodor and the like, and provides a new toothpaste for health care of oral cavity.
Description
Technical field
The invention belongs to filed of daily-use chemical industry, relate to a kind of Chinese herbal toothpaste that contains the Pseudobulbus Bletillae (Rhizoma Bletillae).
Background technology
Toothpaste is essential dental care products in the middle of people's daily life, and its basic function is cleaning teeth, fresh breath.In recent years; because the variation of people's living habit and consumption idea; toothpaste has been proposed more requirement; various toothpaste with health care emerge in large numbers on market; especially Chinese herb medicine toothpaste occupies the huge market share; Chinese herbal toothpaste has and suppresses oral cavity noxious bacteria, fresh breath, takes care of one's teeth, prevents and treats health care such as oral disease, and the product of listing has Herba Pileae Scriptae toothpaste, tianqi toothpaste, Flos Lonicerae odontopathy paste, shiny pricklyash toothpaste etc.The fabricating technology of toothpaste is very ripe at present.The objective of the invention is to seek tooth, oral cavity, throat are had the Chinese herbal medicine of better health-care effect, and be applied to toothpaste.
Streptococcus mutans is the representational antibacterial of research dental plaque biomembrane, with the substantial connection that has of dental caries.Streptococcus mutans coheres plain as albumen P1 by bacterium surface, protein acceptor in the identification saliva film--saliva agglutinin, rich acidic dried meat albumen and take place specificity in conjunction with and the mediation Streptococcus mutans sticks and is settled in facing, form dental plaque, utilize carbohydrate to produce acid, causing tooth local environment pH value descends, the enamel demineralization, and then produce dental caries.In fact, cariogenic bacterias such as mutans streptococcus are the oral cavity normal flora, and dental caries is flora disruption of ecological balance disease in itself.Therefore, seek a kind of safe in utilizationly, can effectively nurse one's health the emphasis that the equilibrated anticariogenic agent of oral cavity flora becomes dental caries research.Prevent and treat the generally employing mechanical removal method of dental caries at present, promptly brush teeth and dental floss removing bacterial plaque with toothbrush.Brush teeth with fluoride dental cream and to prevent and treat dental caries public use already.But modern medicine finds by the microdetermination technological means, and at high fluorine with do not lack the fluorine area to the fluoride dental cream user, by the microanalysis discovery of its hair, its fluorine average more not user has significant difference.Therefore, the use to fluoride should adopt a cautious attitude need according to the various places different condition.
Correlational study shows: the Pseudobulbus Bletillae (Rhizoma Bletillae) may be relevant with some chemical compound in the Pseudobulbus Bletillae (Rhizoma Bletillae) glue to the inhibitory action of Streptococcus mutans.Though its bacteriostasis is remarkable not as hibitane liquid, the Pseudobulbus Bletillae (Rhizoma Bletillae) is that the natural Chinese medicinal herb toxic and side effects is little, might become a kind of new-type traditional Chinese caries preventive agent.
The Pseudobulbus Bletillae (Rhizoma Bletillae) [Blettila striata (Thunb.) Reichb.f.] the orchid family Pseudobulbus Bletillae (Rhizoma Bletillae) belongs to, claim the little Pseudobulbus Bletillae (Rhizoma Bletillae), lotus and grass, sweet, Bletilla striata (Thunb.ex A.Murray)Rchb.f., bamboo foxtail millet glue, snow as not again, the Pseudobulbus Bletillae (Rhizoma Bletillae) is used as Chinese medicine over the past thousands of years always, its major function is to hold back skin ulcer hemostasis, tonifying the lung, detumescence and promoting granulation, can treat haematemesis, pneumonopathy, hemoptysis, ulcer etc.Pseudobulbus Bletillae (Rhizoma Bletillae) rubber powder and Pseudobulbus Bletillae (Rhizoma Bletillae) glucomannoglycan glue are the pharmaceutic adjuvant and the quite promising biomedical materials of medical material, performance brilliance safely and efficiently.
Paeonol (paeonol) is one of main active of Chinese medicine Cortex Moutan and Chinese medicine Radix Cynanchi Paniculati.Chemistry 2-hydroxyl by name-4-methoxyacetophenone.Paeonol has multiple pharmacological effect such as anti-inflammation, antioxidation, antiallergic, inhibition platelet aggregation, has purposes widely in fields such as medicine, spice, chemical industry.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese herbal toothpaste that contains the Pseudobulbus Bletillae (Rhizoma Bletillae) and paeonol.
Chinese herbal toothpaste made from bletilla striata provided by the invention, contain have detumescence and promoting granulation, hold back the Chinese medicine Pseudobulbus Bletillae (Rhizoma Bletillae) of skin ulcer anastalsis and anti-inflammation, the paeonol of anti-allergic effects.
The present invention can realize by following technical method:
A kind of Chinese herbal toothpaste made from bletilla striata comprises lotion of toothpaste substrate, wherein contains the paeonol and the Pseudobulbus Bletillae (Rhizoma Bletillae) or Pseudobulbus Bletillae polysaccharose.
Described Chinese herbal toothpaste made from bletilla striata, wherein the content of the Pseudobulbus Bletillae (Rhizoma Bletillae) or Pseudobulbus Bletillae polysaccharose accounts for 0.05%～10% of toothpaste total composition mass percent by Pseudobulbus Bletillae polysaccharose, and the content of paeonol accounts for 0.01%～5% of toothpaste total composition mass percent.Because the active component content difference of different Pseudobulbus Bletillae (Rhizoma Bletillae) extract drugs methods, and cause action effect difference, test is indicated as and reaches effective function, and the Pseudobulbus Bletillae (Rhizoma Bletillae) of micronizing or homogenizing (Pseudobulbus Bletillae polysaccharose content is greater than 30%) active component content is lower, and preferred values is 5%～10%; And water is carried, the Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides of alcohol precipitation process (Pseudobulbus Bletillae polysaccharose content is greater than 75%) content preferred values is 0.1%～8%; Through purified Pseudobulbus Bletillae polysaccharose (Pseudobulbus Bletillae polysaccharose content is greater than 95%) preferred values is 0.05%～5%.
Described Chinese herbal toothpaste made from bletilla striata, the wherein said Pseudobulbus Bletillae (Rhizoma Bletillae) are the common bletilla that the extra dry white wine splendid achnatherum obtains through micronizing; Perhaps the Pseudobulbus Bletillae (Rhizoma Bletillae) is that the bright Pseudobulbus Bletillae (Rhizoma Bletillae) is through pulverizing the serosity of homogenizing.
The Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides that described Chinese herbal toothpaste made from bletilla striata, the wherein said Pseudobulbus Bletillae (Rhizoma Bletillae) be the Pseudobulbus Bletillae (Rhizoma Bletillae) via water extraction, concentrate, the ethanol precipitation remove impurity obtains.
Described Chinese herbal toothpaste made from bletilla striata, the wherein said Pseudobulbus Bletillae (Rhizoma Bletillae) be the Pseudobulbus Bletillae (Rhizoma Bletillae) via water extraction, concentrate, the ethanol precipitation remove impurity obtains Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides, again through organic solvent washing, and the refining Pseudobulbus Bletillae polysaccharose that Protease Treatment obtains.Organic solvent is selected from one or more in ethanol, ethyl acetate, acetone, the ether, and protease is one or more in neutral protease, alkaline protease, papain, the compound protease.
Specifically, Pseudobulbus Bletillae (Rhizoma Bletillae) powder can be broken to 20 orders～40 orders and add 1:8～1:20 (w/w) water doubly and extract 2～8h, filtration, concentrate in 40 ℃～70 ℃, the Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides that obtains with 75%～95% ethanol precipitation.Further, with the Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides that extracts again through organic solvent washing, the refining Pseudobulbus Bletillae polysaccharose that Protease Treatment obtains.The concrete technology of refining Pseudobulbus Bletillae polysaccharose is seen patent application (application number is " 200710191991.6 ", name is called " fine purification technique for bletilla striata polyoses glue ", publication number is CN101195839).
Described Chinese herbal toothpaste made from bletilla striata, the wherein said Pseudobulbus Bletillae (Rhizoma Bletillae) are the glucomannoglycan polysaccharide chemical constituent in the Pseudobulbus Bletillae (Rhizoma Bletillae).
Described Chinese herbal toothpaste made from bletilla striata, wherein the chemical constituent of paeonol is 2-hydroxyl-4-methoxyacetophenone.
Described Chinese herbal toothpaste made from bletilla striata, wherein lotion of toothpaste substrate mainly is made up of abrasivus, binding agent, wetting agent, surfactant, sweeting agent, antiseptic and essence.Described lotion of toothpaste substrate can be selected any in the various toothpaste matrixes in the prior art for use.
Say that strictly toothpaste divides mastic, flexible pipe two large divisions, toothpaste of the present invention, lotion of toothpaste all refer to mastic.
Beneficial effect of the present invention:
The present invention has adopted and added the Chinese herbal medicine Pseudobulbus Bletillae (Rhizoma Bletillae) that has detumescence and promoting granulation, holds back the skin ulcer anastalsis in lotion of toothpaste substrate, and add paeonol according to the proportioning of science, make Chinese herbal toothpaste of the present invention have anti-inflammation, hold back effect such as skin ulcer hemostasis, can be used for oral cavity and dental disorders such as anti-treating dental ulcer, laryngopharynx swelling and pain, periodontitis, gingivitis, preventing decayed tooth, halitosis.The present invention is applied to toothpaste with the composite paeonol of the Pseudobulbus Bletillae (Rhizoma Bletillae) and does not see relevant report both at home and abroad, and this will provide a kind of new oral cavity health toothpaste to modern people's life.
Each uses once sooner or later every day for Chinese herbal toothpaste of the present invention, has significant anti-inflammation hemostasia, repairs the oral ulcer effect, simultaneously oral cavity such as laryngopharynx swelling and pain, periodontitis, gingivitis, preventing decayed tooth, halitosis and dental disorder is had good preventive and therapeutic effect.
Chinese herbal toothpaste result of use of the present invention is observed:
1, choice criteria: select case by the conventional diagnostic criteria of assert of medical treatment.
2, user ordinary circumstance: age: 16～63 years old; Man's 57 examples, women 43 examples;
3, using method: the Chinese herbal toothpaste of the present invention every day of each use sooner or later once between the operating period, does not add and uses other drug, when being associated with other complication, and the therapy of can supporting and symptomatic treatment.
4, criterion of therapeutical effect: a, effect are remarkable: symptom disappears substantially; B, effective: symptom is most of to take a turn for the better; C, not obvious: do not reach effective standard or sx person.
5, observation of curative effect result: observed 3～14 days, and the results are shown in Table 1.
Table 1 Chinese herbal toothpaste result of use of the present invention statistical table
The specific embodiment
The invention will be further elaborated by the following examples.
The technological parameter of toothpaste Paste Preparation can be among the embodiment:
(1) the Production Regional temperature is not less than 10 ℃.
(2) liquid material, solid (powder) error in dipping are not more than 0.5%.
(3) pre-dispersed device stainless steel reaction pot, scraper plate mixing speed 20rpm disperses mixing speed 1000rpm fast.
(4) predissolve metal v-belt lid stainless steel reaction pot, dissolving mixing speed 500～1000rpm, the deionized water temperature is not more than 60 ℃.
(5) vacuum is not less than-0.094mpa.
The preparation method of lotion of toothpaste can adopt arbitrary method well known to those skilled in the art.Method as present manufacturing lotion of toothpaste is generally glue water, mix, grinding, four master operations of the degassing: glycerol, binding agent are dropped in the reaction pot, moistening is stirred, add former materials such as the glucide (or saccharin sodium) dissolved, water again, continue to stir, make the glue of making be evenly translucent sticking shape liquid state, store, allow it fully dissolve the back of expanding and use; Various solid, powdery raw materials and the glue for preparing, essence etc. are dropped in the reaction pots, stir by mechanical mixture, make have certain viscosity, rare thick suitable mastic; Mastic grinds through grinder, can granule thick, really up to the mark excessively is levigate, make mastic exquisiteness, even, stable, and grinding can divide secondary to carry out, and mill back storage for the first time will be carried out vacuum outgas after grinding for the second time; Mastic after the degassing can be filled into flexible pipe after leaving standstill.
Embodiment 1
The weight percentages of components of lotion of toothpaste is composed as follows:
Glycerol 5～15%
Sorbitol 10～20%
Guar gum 0.5～1%
Sodium carboxymethyl cellulose 0.7～1%
Saccharin sodium 0.2～0.3%
Essence 0.3～1%
Sodium lauryl sulphate 1.8～2.5%
Silicon dioxide 5～10%
Calcium carbonate 30～40%
Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 2.5～10%
Sodium benzoate 0.1～0.2%
Paeonol 0.01～0.05%
The deionized water surplus
Embodiment 2
The weight percentages of components of making the transparent toothpaste mastic is composed as follows:
Glycerol 10～30%
Sorbitol 20～40%
Sodium carboxymethyl cellulose 0.8～1%
Saccharin sodium 0.2～0.3%
Sodium lauryl sulphate 1.8～2.5%
Essence 0.8～1.2%
Silica 1 8～28%
Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides 0.5～2%
Paeonol 0.03～0.1%
The deionized water surplus
Wherein the preparation method of Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides is: Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken to 20 orders～40 orders, adds 1:8～1:20 (w/w) water doubly in 40 ℃～70 ℃ extraction 2～8h, filters, concentrates, and with 75%～95% ethanol precipitation, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides.
Embodiment 3
The weight percentages of components of making high-grade lotion of toothpaste is composed as follows:
Glycerol 10～20%
Sorbitol 10～20%
Sodium carboxymethyl cellulose 0.8～1%
Saccharin sodium 0.2～0.3%
Sodium lauryl sulphate 1.8～2.5%
Essence 0.8～1.2%
Silicon dioxide 3～6%
Calcium carbonate 40～48%
Sodium benzoate 0.05～0.08%
Refining Pseudobulbus Bletillae polysaccharose 0.05～1%
Paeonol 0.05～1%
The deionized water surplus
Wherein the preparation method of refining Pseudobulbus Bletillae polysaccharose is:
Pseudobulbus Bletillae (Rhizoma Bletillae) powder is broken to 20 orders～40 orders, adds 1:8～1:20 (w/w) water doubly and extracts 2～8h in 40 ℃～70 ℃, filters, concentrates, the Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides that obtains with 75%～95% ethanol precipitation.
Take by weighing Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides, adding concentration by weight of material volume ratio 1:4 is 70% alcoholic solution (being Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides 100g, 70% pure 400ml), sets bath temperature to 70 ℃, heating 1h, cooling then.Vacuum filtration is 95% washing with alcohol three times with concentration.Accurately take by weighing weighing apparatus dry weight Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides sample after the washing with alcohol, ratio in 30ml water/g washing back weighing apparatus dry weight Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides adds entry, place 50 ℃ of water-baths, constantly stir, make it abundant dissolving, add neutral protease by 0.5% of washing back weighing apparatus dry weight Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides weight, regulate pH6.5-7.0,50 ℃ of complete hydrolysis 20h.70 ℃ of enzyme denaturing of enzymolysis solution are handled 10min, use High speed refrigerated centrifuge 6000r/min, centrifugal 15min.Inclining supernatant, adds 95% ethanol of 4 times of supernatant volumes, precipitate with ethanol 4h final vacuum sucking filtration, and the Pseudobulbus Bletillae (Rhizoma Bletillae) glue purity behind the vacuum filtration is 95% washing with alcohol 2 times, washing with acetone 3 times, ether washing 3 times, filter is done, and stores after drying 2h for 60 ℃.
Protease also can adopt following protease to handle:
Enzyme class optimum temperature (℃) pH scope consumption (%)
Papain 55 5.5 ± 0.5 0.2
Alkaline protease 65 7.0-8.0 0.6
Compound protease 48 8.0 ± 0.5 0.15
The organic solvent of washing usefulness can adopt one or more in ethanol, ethyl acetate, acetone, the ether.
Claims (9)
1, a kind of Chinese herbal toothpaste made from bletilla striata comprises lotion of toothpaste substrate, it is characterized in that containing the paeonol and the Pseudobulbus Bletillae (Rhizoma Bletillae) or Pseudobulbus Bletillae polysaccharose.
2, Chinese herbal toothpaste made from bletilla striata according to claim 1, the content that it is characterized in that the Pseudobulbus Bletillae (Rhizoma Bletillae) or Pseudobulbus Bletillae polysaccharose accounts for 0.05%～10% of toothpaste total composition mass percent by Pseudobulbus Bletillae polysaccharose, and the content of paeonol accounts for 0.01%～5% of toothpaste total composition mass percent.
3, Chinese herbal toothpaste made from bletilla striata according to claim 1 is characterized in that the described Pseudobulbus Bletillae (Rhizoma Bletillae) is the common bletilla that the extra dry white wine splendid achnatherum obtains through micronizing; Perhaps the Pseudobulbus Bletillae (Rhizoma Bletillae) is that the bright Pseudobulbus Bletillae (Rhizoma Bletillae) is through pulverizing the serosity of homogenizing.
4, Chinese herbal toothpaste made from bletilla striata according to claim 1, it is characterized in that described Pseudobulbus Bletillae polysaccharose be the Pseudobulbus Bletillae (Rhizoma Bletillae) via water extraction, concentrate, Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides that the ethanol precipitation remove impurity obtains.
5, Chinese herbal toothpaste made from bletilla striata according to claim 1, it is characterized in that described Pseudobulbus Bletillae polysaccharose be the Pseudobulbus Bletillae (Rhizoma Bletillae) via water extraction, concentrate, the ethanol precipitation remove impurity obtains Pseudobulbus Bletillae (Rhizoma Bletillae) crude polysaccharides, again through organic solvent washing, the refining Pseudobulbus Bletillae polysaccharose that Protease Treatment obtains.
6, Chinese herbal toothpaste made from bletilla striata according to claim 5, it is characterized in that organic solvent is selected from one or more in ethanol, ethyl acetate, acetone, the ether, protease is one or more in neutral protease, alkaline protease, papain, the compound protease.
7, Chinese herbal toothpaste made from bletilla striata according to claim 1 is characterized in that described Pseudobulbus Bletillae polysaccharose is the glucomannoglycan polysaccharide chemical constituent in the Pseudobulbus Bletillae (Rhizoma Bletillae).
8, Chinese herbal toothpaste made from bletilla striata according to claim 1, the chemical constituent that it is characterized in that paeonol are 2-hydroxyl-4-methoxyacetophenone.
9, Chinese herbal toothpaste made from bletilla striata according to claim 1 is characterized in that lotion of toothpaste substrate mainly is made up of abrasivus, binding agent, wetting agent, surfactant, sweeting agent, antiseptic and essence.
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Cited By (18)
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| CN102784209A (en) * | 2012-08-10 | 2012-11-21 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN103445980A (en) * | 2013-08-24 | 2013-12-18 | 上海方木精细化工有限公司 | Paeonol tooth protection toothpaste |
| CN103520052A (en) * | 2013-10-18 | 2014-01-22 | 柳州两面针股份有限公司 | Application of hyacinth bletilla extract in preparing oral care product |
| CN104013547A (en) * | 2014-05-26 | 2014-09-03 | 皖南医学院 | Toothpaste for stopping bleeding, brightening and refreshing breath and preparation method thereof |
| CN104173253A (en) * | 2014-08-08 | 2014-12-03 | 侨健新能源科技（苏州）有限公司 | Children toothpaste for preventing decayed teeth |
| CN105168086A (en) * | 2014-09-10 | 2015-12-23 | 上海百念商贸有限公司 | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste |
| CN106137853A (en) * | 2016-08-17 | 2016-11-23 | 林少英 | A kind of fresh breath toothpaste |
| CN106389188A (en) * | 2016-07-21 | 2017-02-15 | 上海蔚艺生物科技有限公司 | Chinese herbal medicine toothpaste containing radix tetrastigme and rhizoma bletillae |
| CN106580866A (en) * | 2017-03-03 | 2017-04-26 | 皖南医学院 | Toothpaste for children |
| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN106860122A (en) * | 2016-12-28 | 2017-06-20 | 贵州艾力康中草药开发有限公司 | A kind of Blumea balsamifera toothpaste for preventing canker sore and preparation method thereof |
| CN107811941A (en) * | 2017-11-21 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | One kind shield gum toothpaste |
| CN108125813A (en) * | 2018-01-17 | 2018-06-08 | 卢鹤文 | Tooth liquid is gargled in a kind of bactericidal antiphlogistic detumescence |
| CN108670889A (en) * | 2018-07-25 | 2018-10-19 | 佛山市仁汇医药科技有限公司 | A kind of toothpaste and preparation method thereof of anti-treating dental ulcer |
| CN109276475A (en) * | 2018-11-20 | 2019-01-29 | 湖北中医药大学 | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof |
| CN110090188A (en) * | 2019-05-08 | 2019-08-06 | 广州淡韵生物科技有限公司 | A kind of Chinese medicinal toothpaste and preparation method thereof |
| CN110384646A (en) * | 2018-04-20 | 2019-10-29 | 毛怡 | A kind of bletilla striata toothpaste and its preparation process |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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2008
- 2008-09-26 CN CN2008101571989A patent/CN101380285B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102784209B (en) * | 2012-08-10 | 2014-12-17 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN102784209A (en) * | 2012-08-10 | 2012-11-21 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN103445980A (en) * | 2013-08-24 | 2013-12-18 | 上海方木精细化工有限公司 | Paeonol tooth protection toothpaste |
| CN103445980B (en) * | 2013-08-24 | 2016-03-02 | 上海方木精细化工有限公司 | Paeonol tooth protection toothpaste |
| CN103520052A (en) * | 2013-10-18 | 2014-01-22 | 柳州两面针股份有限公司 | Application of hyacinth bletilla extract in preparing oral care product |
| CN104013547A (en) * | 2014-05-26 | 2014-09-03 | 皖南医学院 | Toothpaste for stopping bleeding, brightening and refreshing breath and preparation method thereof |
| CN104173253A (en) * | 2014-08-08 | 2014-12-03 | 侨健新能源科技（苏州）有限公司 | Children toothpaste for preventing decayed teeth |
| CN105168086A (en) * | 2014-09-10 | 2015-12-23 | 上海百念商贸有限公司 | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste |
| CN106389188A (en) * | 2016-07-21 | 2017-02-15 | 上海蔚艺生物科技有限公司 | Chinese herbal medicine toothpaste containing radix tetrastigme and rhizoma bletillae |
| CN106137853A (en) * | 2016-08-17 | 2016-11-23 | 林少英 | A kind of fresh breath toothpaste |
| CN106821902A (en) * | 2016-12-23 | 2017-06-13 | 李大兴 | A kind of Chinese medicinal toothpaste |
| CN106860122A (en) * | 2016-12-28 | 2017-06-20 | 贵州艾力康中草药开发有限公司 | A kind of Blumea balsamifera toothpaste for preventing canker sore and preparation method thereof |
| CN106580866A (en) * | 2017-03-03 | 2017-04-26 | 皖南医学院 | Toothpaste for children |
| CN106580866B (en) * | 2017-03-03 | 2019-11-12 | 皖南医学院 | Children's toothpaste |
| CN107811941A (en) * | 2017-11-21 | 2018-03-20 | 丹东欣时代生物医药科技有限公司 | One kind shield gum toothpaste |
| CN108125813A (en) * | 2018-01-17 | 2018-06-08 | 卢鹤文 | Tooth liquid is gargled in a kind of bactericidal antiphlogistic detumescence |
| CN110384646A (en) * | 2018-04-20 | 2019-10-29 | 毛怡 | A kind of bletilla striata toothpaste and its preparation process |
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| CN109276475A (en) * | 2018-11-20 | 2019-01-29 | 湖北中医药大学 | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof |
| CN109276475B (en) * | 2018-11-20 | 2021-12-03 | 湖北中医药大学 | Traditional Chinese medicine toothpaste containing bletilla striata polysaccharide and preparation method thereof |
| CN110090188A (en) * | 2019-05-08 | 2019-08-06 | 广州淡韵生物科技有限公司 | A kind of Chinese medicinal toothpaste and preparation method thereof |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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Address after: Xuanwu District of Nanjing City, Jiangsu province 210042 Jiang Wang Temple Street No. 4 Patentee after: NANJING INST OF COMPREHENSIVE UTILIZATION OF WILD PLANT CHINA COOP Patentee after: GUANGDONG KANGWANG COSMETICS CO.,LTD. Address before: Xuanwu District of Nanjing City, Jiangsu province 210042 Jiang Wang Temple Street No. 4 Patentee before: NANJING INST OF COMPREHENSIVE UTILIZATION OF WILD PLANT CHINA COOP Patentee before: SHANTOU KANGWANG FINE CHEMICAL Co.,Ltd. |
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