CN113925823A - Edible sugar-free probiotic chewing gum bead-blasting solid mouth wash and preparation method thereof - Google Patents
Edible sugar-free probiotic chewing gum bead-blasting solid mouth wash and preparation method thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/73—Polysaccharides
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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Abstract
An edible sugar-free probiotic chewing gum bead-blasting solid mouthwash and a preparation method thereof, which belong to the technical field of mouthwashes and particularly relate to a solid mouthwash and a preparation method thereof. The invention aims to solve the problems that the existing liquid type mouthwash is inconvenient to carry and the existing solid type mouthwash is inconvenient to use. The edible sugar-free probiotic bacteria chewing gum bead solid mouth wash comprises a solid wall and a liquid core, wherein the solid wall comprises sodium alginate, seaweed gel and calcium lactate, the liquid core comprises natural plant essential oil, lemon grass extract, mint extract, honeysuckle extract, bifidobacterium bifidum, cannabidiol and a sweetening agent, and the sweetening agent comprises fructo-oligosaccharide, D-xylose and thaumatin. The preparation method comprises the following steps: firstly, preparing a lemongrass extract; secondly, preparing a mint extract; thirdly, preparing a honeysuckle extract; fourthly, preparing cannabidiol; fifthly, preparing calcium lactate solution; sixthly, mixing; and seventhly, molding. The invention is mainly used for preparing the edible sugar-free probiotic bacteria chewing gum bead-blasting solid mouthwash.
Description
Technical Field
The invention belongs to the technical field of mouthwash, and particularly relates to solid mouthwash and a preparation method thereof.
Background
With the emphasis of people on health, on the basis of tooth brushing, the mouthwash becomes one of oral cavity cleaning modes of people, can effectively control bacterial plaque, can penetrate into various parts of the oral cavity, reduces bacteria and bacterial plaque causing halitosis, and improves the health of gums; the existing mouthwash is divided into liquid mouthwash and solid mouthwash, the liquid mouthwash is convenient to use, but the liquid mouthwash must be stored in a container, so that the carrying is inconvenient; solid type mouth wash is divided into tablet type and powder type, and although it is more convenient to carry than liquid type mouth wash, it is necessary to rinse mouth with water when using, which causes inconvenience in use.
Disclosure of Invention
The invention aims to solve the problems that the existing liquid type mouth wash is inconvenient to carry and the solid type mouth wash is inconvenient to use, and provides the edible sugar-free probiotic mouth wash and the preparation method thereof.
The edible sugar-free probiotic chewing gum bead solid mouth wash comprises a solid wall and a liquid core, wherein the solid wall comprises sodium alginate, seaweed gel and calcium lactate, the liquid core comprises 10-20 parts by weight of natural plant essential oil, 0.5-1 part by weight of lemon grass extract, 1-2 parts by weight of mint extract, 0.5-1 part by weight of honeysuckle extract, 0.5-1 part by weight of bifidobacterium bifidum, 0.005-0.01 part by weight of cannabidiol and 3-5 parts by weight of sweetening agent, and the sweetening agent comprises fructo-oligosaccharide, D-xylose and thaumatin.
A preparation method of an edible sugar-free probiotic chewing gum bead-blasting solid mouthwash is specifically completed according to the following steps:
firstly, preparing a lemon grass extract: cutting dry lemon grass, adding water to soak for 1-2 h, covering the lemon grass, heating to boil, decocting for 1-2 h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 5-8; adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1-2 h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 1-3; thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.5-1 h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 0.5-1.5; fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 15% -30% of the total liquid amount, cooling and sterilizing to obtain a lemongrass extract;
secondly, preparing the mint extract: firstly, adding water into fresh mint, mixing and pulping, then adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35-40 ℃ for 12-14 h to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2-3; the mass ratio of the fresh mint to the pectinase is 100: 2-3; secondly, performing supercritical extraction on the mint enzymolysis pulp, and performing ultrasonic extraction for 240-300 min under the conditions that the temperature is 60-70 ℃ and the power is 250-280W to obtain mint extracting solution; thirdly, freezing the mint extract, filtering, and then drying by microwave under the conditions that the temperature is 112-118 ℃ and the power is 166-174W to obtain the mint extract;
thirdly, preparing a honeysuckle extract: firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in single extraction is 1: 10-15, and the single extraction time is 2-3 h; secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate; thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 40-75 ℃ until the solid content reaches more than 50% to obtain a concentrated solution, and carrying out vacuum drying on the concentrated solution to obtain a honeysuckle extract;
fourthly, preparing cannabidiol:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1-2 h at the temperature of 102-120 ℃, naturally cooling the industrial hemp powder to normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 40-60 ℃, and the pressure is 25-35 MPa; the flow rate of the carbon dioxide gas passing through the extraction kettle is 35L/h-45L/h, the extraction time is 1.5 h-2.5 h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heating furnace at 180-200 ℃ and the temperature of an auxiliary heat conduction furnace at 100-120 ℃, and collecting light component oil, wherein the vacuum degree of the molecular short-path distiller is 20-80 Pa, the rotation speed of the molecular short-path distiller is 100-200 r/min; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 1-2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 10% -50%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, performing isocratic elution for 60-80 min by using 50-80% ethanol solution, wherein the collection starting time is 10-15 min, and the collection finishing time is 50-70 min to obtain the cannabidiol, wherein the THC content in the cannabidiol is less than 0.3%;
fifthly, preparing a calcium lactate solution: adding calcium lactate into water, dissolving for 0.5-1 h, sterilizing by using an autoclave, and cooling to room temperature to obtain a calcium lactate solution, wherein the mass fraction of calcium lactate in the calcium lactate solution is 3% -4%;
sixthly, mixing: weighing 10-20 parts of natural plant essential oil, 0.5-1 part of lemon grass extract, 1-2 parts of mint extract, 0.5-1 part of honeysuckle extract, 0.5-1 part of bifidobacterium bifidum, 0.005-0.01 part of cannabidiol and 3-5 parts of sweetener according to parts by weight; the sweetener comprises fructo-oligosaccharide, D-xylose and thaumatin; the mass ratio of fructo-oligosaccharide to D-xylose in the sweetener is 1: 2; the mass ratio of the fructo-oligosaccharide to the thaumatin is 1: 0.5; adding the natural plant essential oil weighed in the sixth step into water, and processing the natural plant essential oil into emulsion by using an emulsifying machine; thirdly, adding seaweed glue and sodium alginate into the emulsion, and homogenizing and uniformly mixing after completely dissolving to obtain a primary mixture; adding the lemongrass extract, the mint extract, the honeysuckle extract, the cannabidiol and the sweetener which are weighed in the sixth step into the primary mixture, uniformly mixing, sterilizing by using an autoclave, adding the bifidobacterium bifidum weighed in the sixth step, homogenizing and uniformly mixing to obtain a mixture;
seventhly, forming: and (3) uniformly dripping the mixture into the calcium lactate solution prepared in the fourth step by using a dropper with the diameter of 15-20 mm to form liquid beads in the calcium lactate solution to obtain a liquid bead-containing calcium lactate solution, refrigerating the liquid bead-containing calcium lactate solution at the temperature of 4 ℃ for 0.5-2 h, taking out the liquid beads, cleaning the liquid beads by using sterile distilled water, collecting the cleaned liquid beads, and carrying out vacuum packaging to obtain the edible sugar-free probiotic chewing gum bead-popping solid mouth wash.
The invention has the advantages and the principle that:
the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash comprises a solid wall and a liquid core, wherein sodium alginate, seaweed gel and calcium lactate are used as solid wall raw materials, sodium alginate and calcium lactate are crosslinked to form a bead-blasting outer film, seaweed gel is used as a binder, the bead-blasting outer film can be solidified to form a stable solid wall, so that the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash has the advantage of convenience in carrying of the solid mouthwash, and meanwhile, the coated liquid core overflows after the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash is bitten, and the liquid core has the advantage of convenience in using of the liquid mouthwash;
second, natural plant essential oil is added into the liquid core of the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash, and the natural plant essential oil can refresh breath, reduce inflammation and redness and swelling of gums and prevent thick and heavy tongue fur;
thirdly, lemon grass extract, mint extract and honeysuckle extract are added into the liquid core of the edible sugar-free probiotic chewing gum bead solid mouthwash; the lemon grass has the effects of resisting bacteria, stopping bleeding, eliminating edema and the like, has a good repairing effect on ulcer, redness and swelling, gingival bleeding and the like in the oral cavity, and meanwhile, the lemon grass is fragrant in smell and pleasant in fragrance, can refresh breath and eliminate halitosis; the mint is pungent and cool in nature, has the effects of sweating and relieving fever, clearing throat and detoxifying, and relieving swelling and pain, and the mint contains menthol, so that the mint is fresh in smell, has various medicinal properties and has a certain effect on stomatitis; the honeysuckle is sweet and cold in nature, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving swelling, and can promote the phagocytic function of inflammatory cells, so that pathogenic microorganisms are eliminated, and chlorogenic acid rich in the honeysuckle has a wide antibacterial effect and is one of the main antibacterial and antiviral effective pharmacological components.
The fructo-oligosaccharide, the D-xylose and the thaumatin are adopted as the sweetening agents, the sweetening agents cannot be digested and absorbed by human bodies, the sweetening agents are added without sugar, the novel sugar-free sweetmeat is suitable for type II diabetes, meanwhile, the fructo-oligosaccharide and the D-xylose can also effectively prevent decayed teeth, and can have a prebiotic function (prebiotics are a general name of substances which enable probiotics to better play a role), the thaumatin is a natural energy-free sweetening agent, is synthesized by non-traditional manual work, is a protein component, cannot generate energy, has high sweetness which is 800-30000 times of that of cane sugar, and cannot cause harmful bacteria reproduction in oral cavities;
and fifthly, cannabidiol is added into the liquid core of the edible sugar-free probiotic chewing gum bead solid mouthwash, and the cannabidiol has the effects of relieving pain and diminishing inflammation, and guiding neutrophil aggregation to inhibit allergic inflammation.
Sixthly, bifidobacterium bifidum is added into the liquid core of the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash, so that the bacterial colony in the oral cavity of a human body can be improved, harmful bacteria can be eliminated, and decayed teeth and other oral diseases can be prevented;
and seventhly, the product adopts natural plant water-soluble extracts and edible sweetening agents, sodium alginate and calcium lactate are also food-grade raw materials, bifidobacterium bifidum is also common edible probiotics, and the operation and the sterilization of the bifidobacterium bifidum also meet the food sanitation standard, so that the edible sugar-free probiotic chewing gum bead-popping solid mouth wash can be eaten.
Detailed Description
The first embodiment is as follows: the embodiment is an edible sugar-free probiotic chewing gum and bead blasting solid mouthwash, which comprises a solid wall and a liquid core, wherein the solid wall comprises sodium alginate, seaweed gel and calcium lactate, the liquid core comprises 10-20 parts by weight of natural plant essential oil, 0.5-1 part by weight of lemon grass extract, 1-2 parts by weight of mint extract, 0.5-1 part by weight of honeysuckle extract, 0.5-1 part by weight of bifidobacterium bifidum, 0.005-0.01 part by weight of cannabidiol and 3-5 parts by weight of sweetening agent, and the sweetening agent comprises fructo-oligosaccharide, D-xylose and thaumatin.
The second embodiment is as follows: the present embodiment differs from the present embodiment in that: the preparation process of the lemon grass extract is as follows:
cutting dry lemon grass, adding water to soak for 1-2 h, covering the lemon grass, heating to boil, decocting for 1-2 h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 5-8;
adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1-2 h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 1-3;
thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.5-1 h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 0.5-1.5;
and fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 15% -30% of the total liquid amount, and cooling and sterilizing to obtain the lemongrass extract.
The rest is the same as the first embodiment.
The third concrete implementation mode: the present embodiment differs from the first or second embodiment in that: the preparation process of the mint extract comprises the following steps:
firstly, adding water into fresh mint, mixing and pulping, then adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35-40 ℃ for 12-14 h to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2-3; the mass ratio of the fresh mint to the pectinase is 100: 2-3;
secondly, performing supercritical extraction on the mint enzymolysis pulp, and performing ultrasonic extraction for 240-300 min under the conditions that the temperature is 60-70 ℃ and the power is 250-280W to obtain mint extracting solution;
and thirdly, freezing the mint extract, filtering, and then drying by microwave at the temperature of 112-118 ℃ and the power of 166-174W to obtain the mint extract.
The others are the same as in the first or second embodiment.
The fourth concrete implementation mode: the difference between this embodiment and one of the first to third embodiments is as follows: the preparation process of the honeysuckle extract comprises the following steps:
firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in single extraction is 1: 10-15, and the single extraction time is 2-3 h;
secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate;
thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 40-75 ℃ until the solid content reaches more than 50%, obtaining a concentrated solution, and carrying out vacuum drying on the concentrated solution, thus obtaining the honeysuckle extract.
The others are the same as the first to third embodiments.
The fifth concrete implementation mode: the difference between this embodiment and one of the first to fourth embodiments is: the cannabidiol is prepared according to the following process:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1-2 h at the temperature of 102-120 ℃, naturally cooling the industrial hemp powder to normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 40-60 ℃, and the pressure is 25-35 MPa; the flow rate of the carbon dioxide gas passing through the extraction kettle is 35L/h-45L/h, the extraction time is 1.5 h-2.5 h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heating furnace at 180-200 ℃ and the temperature of an auxiliary heat conduction furnace at 100-120 ℃, and collecting light component oil, wherein the vacuum degree of the molecular short-path distiller is 20-80 Pa, the rotation speed of the molecular short-path distiller is 100-200 r/min; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 1-2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 10% -50%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, performing isocratic elution for 60-80 min by using 50-80% ethanol solution, wherein the collection starting time is 10-15 min, and the collection finishing time is 50-70 min, thus obtaining the cannabidiol, wherein the THC content in the cannabidiol is less than 0.3%.
The rest is the same as the first to fourth embodiments.
The sixth specific implementation mode: the difference between this embodiment and one of the first to fifth embodiments is as follows: the deposit number of the bifidobacterium bifidum is as follows: CICC 6168. The rest is the same as the first to fifth embodiments.
The seventh embodiment: the difference between this embodiment and one of the first to sixth embodiments is: the mass ratio of the fructo-oligosaccharide to the D-xylose in the sweetener is 1:2, and the mass ratio of the fructo-oligosaccharide to the thaumatin is 1: 0.5. The rest is the same as the first to sixth embodiments.
The specific implementation mode is eight: the embodiment provides a preparation method of an edible sugar-free probiotic chewing gum bead-blasting solid mouthwash, which is specifically completed according to the following steps:
firstly, preparing a lemon grass extract: cutting dry lemon grass, adding water to soak for 1-2 h, covering the lemon grass, heating to boil, decocting for 1-2 h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 5-8; adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1-2 h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 1-3; thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.5-1 h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 0.5-1.5; fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 15% -30% of the total liquid amount, cooling and sterilizing to obtain a lemongrass extract;
secondly, preparing the mint extract: firstly, adding water into fresh mint, mixing and pulping, then adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35-40 ℃ for 12-14 h to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2-3; the mass ratio of the fresh mint to the pectinase is 100: 2-3; secondly, performing supercritical extraction on the mint enzymolysis pulp, and performing ultrasonic extraction for 240-300 min under the conditions that the temperature is 60-70 ℃ and the power is 250-280W to obtain mint extracting solution; thirdly, freezing the mint extract, filtering, and then drying by microwave under the conditions that the temperature is 112-118 ℃ and the power is 166-174W to obtain the mint extract;
thirdly, preparing a honeysuckle extract: firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in single extraction is 1: 10-15, and the single extraction time is 2-3 h; secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate; thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 40-75 ℃ until the solid content reaches more than 50% to obtain a concentrated solution, and carrying out vacuum drying on the concentrated solution to obtain a honeysuckle extract;
fourthly, preparing cannabidiol:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1-2 h at the temperature of 102-120 ℃, naturally cooling the industrial hemp powder to normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 40-60 ℃, and the pressure is 25-35 MPa; the flow rate of the carbon dioxide gas passing through the extraction kettle is 35L/h-45L/h, the extraction time is 1.5 h-2.5 h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heating furnace at 180-200 ℃ and the temperature of an auxiliary heat conduction furnace at 100-120 ℃, and collecting light component oil, wherein the vacuum degree of the molecular short-path distiller is 20-80 Pa, the rotation speed of the molecular short-path distiller is 100-200 r/min; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 1-2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 10% -50%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, performing isocratic elution for 60-80 min by using 50-80% ethanol solution, wherein the collection starting time is 10-15 min, and the collection finishing time is 50-70 min to obtain the cannabidiol, wherein the THC content in the cannabidiol is less than 0.3%;
fifthly, preparing a calcium lactate solution: adding calcium lactate into water, dissolving for 0.5-1 h, sterilizing by using an autoclave, and cooling to room temperature to obtain a calcium lactate solution, wherein the mass fraction of calcium lactate in the calcium lactate solution is 3% -4%;
sixthly, mixing: weighing 10-20 parts of natural plant essential oil, 0.5-1 part of lemon grass extract, 1-2 parts of mint extract, 0.5-1 part of honeysuckle extract, 0.5-1 part of bifidobacterium bifidum, 0.005-0.01 part of cannabidiol and 3-5 parts of sweetener according to parts by weight; the sweetener comprises fructo-oligosaccharide, D-xylose and thaumatin; the mass ratio of fructo-oligosaccharide to D-xylose in the sweetener is 1: 2; the mass ratio of the fructo-oligosaccharide to the thaumatin is 1: 0.5; adding the natural plant essential oil weighed in the sixth step into water, and processing the natural plant essential oil into emulsion by using an emulsifying machine; thirdly, adding seaweed glue and sodium alginate into the emulsion, and homogenizing and uniformly mixing after completely dissolving to obtain a primary mixture; adding the lemongrass extract, the mint extract, the honeysuckle extract, the cannabidiol and the sweetener which are weighed in the sixth step into the primary mixture, uniformly mixing, sterilizing by using an autoclave, adding the bifidobacterium bifidum weighed in the sixth step, homogenizing and uniformly mixing to obtain a mixture;
seventhly, forming: and (3) uniformly dripping the mixture into the calcium lactate solution prepared in the fourth step by using a dropper with the diameter of 15-20 mm to form liquid beads in the calcium lactate solution to obtain a liquid bead-containing calcium lactate solution, refrigerating the liquid bead-containing calcium lactate solution at the temperature of 4 ℃ for 0.5-2 h, taking out the liquid beads, cleaning the liquid beads by using sterile distilled water, collecting the cleaned liquid beads, and carrying out vacuum packaging to obtain the edible sugar-free probiotic chewing gum bead-popping solid mouth wash.
The specific implementation method nine: the present embodiment is different from the eighth embodiment in that: the sterilization of the autoclave in the fifth step is specifically performed as follows: sterilizing with autoclave at 121 deg.C for 5 min. The rest is the same as the embodiment eight.
The detailed implementation mode is ten: the eighth embodiment is different from the ninth embodiment in that: the deposit number of the bifidobacterium bifidum is as follows: CICC 6168. The others are the same as the embodiments eight or nine.
The concrete implementation mode eleven: the eighth to tenth embodiments are different from the first to eighth embodiments in that: sixthly, the mass fraction of the natural plant essential oil in the emulsion is 10-20%. The others are the same as the embodiments eight to ten.
The specific implementation mode twelve: the eighth embodiment differs from the first embodiment in the eighth to eleventh embodiments in that: and sixthly, the mass fraction of the seaweed gel in the primary mixture is 0.2-0.3%, and the mass fraction of the sodium alginate is 0.8-1.2%. The others are the same as the embodiments eight to eleven.
The specific implementation mode is thirteen: the eighth to twelfth points of difference from the embodiment are as follows: the specific operation of the sterilization of the autoclave in the step sixty-four is as follows: sterilizing with autoclave at 121 deg.C for 5 min. The others are the same as the embodiments eight to twelve.
The invention is not limited to the above embodiments, and one or a combination of several embodiments may also achieve the object of the invention.
The following experiments are adopted to verify the effect of the invention:
example 1: a preparation method of an edible sugar-free probiotic chewing gum bead-blasting solid mouthwash is specifically completed according to the following steps:
firstly, preparing a lemon grass extract: cutting dry lemon grass, firstly adding water to soak for 1.5h, covering, heating to boil, decocting for 1.5h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 6.5; adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1.5h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 2; thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.8h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 1; mixing the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 22.5 percent of the total liquid amount, cooling and sterilizing to obtain a lemongrass extract;
secondly, preparing the mint extract: firstly, adding water into fresh mint, mixing and pulping, adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35 ℃ for 13 hours to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2.5; the mass ratio of the fresh mint to the pectinase is 100: 2.5; ② carrying out supercritical extraction on the mint enzymolysis pulp, and carrying out ultrasonic extraction for 270min under the conditions that the temperature is 65 ℃ and the power is 270W to obtain mint extracting solution; thirdly, freezing the mint extract, filtering, and then drying by microwave under the conditions that the temperature is 115 ℃ and the power is 170W to obtain the mint extract;
thirdly, preparing a honeysuckle extract: firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in the single extraction is 1:12.5, and the single extraction time is 2.5 h; secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate; thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 55 ℃ until the solid content reaches more than 50 percent to obtain a concentrated solution, and carrying out vacuum drying on the concentrated solution to obtain a honeysuckle extract;
fourthly, preparing cannabidiol:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1.5 hours at the temperature of 110 ℃, naturally cooling the industrial hemp powder to the normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 50 ℃, and the pressure is 30 MPa; the flow of the carbon dioxide gas passing through the extraction kettle is 40L/h, the extraction time is 2h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heat-conducting furnace at 190 ℃ and the temperature of an auxiliary heat-conducting furnace at 110 ℃, and collecting light oil; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 30%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, isocratic eluting for 70min by using 65% ethanol solution, wherein the collection starting time is 10min, and the collection finishing time is 60min, so that the cannabidiol is obtained, and the THC content in the cannabidiol is less than 0.3%;
fifthly, preparing a calcium lactate solution: adding calcium lactate into water, dissolving for 0.8h, sterilizing at 121 deg.C for 5min with an autoclave, and cooling to room temperature to obtain calcium lactate solution with calcium lactate content of 3.5%;
sixthly, mixing: weighing 15 parts of natural plant essential oil, 0.8 part of lemon grass extract, 1.5 parts of mint extract, 0.8 part of honeysuckle extract, 0.8 part of bifidobacterium bifidum, 0.0075 parts of cannabidiol and 4 parts of sweetener according to parts by weight; the sweetener comprises fructo-oligosaccharide, D-xylose and thaumatin; the mass ratio of fructo-oligosaccharide to D-xylose in the sweetener is 1: 2; the mass ratio of the fructo-oligosaccharide to the thaumatin is 1: 0.5; adding the natural plant essential oil weighed in the sixth step into water, and processing the natural plant essential oil into emulsion by using an emulsifying machine; thirdly, adding seaweed glue and sodium alginate into the emulsion, and homogenizing and uniformly mixing after completely dissolving to obtain a primary mixture; adding the lemon grass extract, the mint extract, the honeysuckle extract, the cannabidiol and the sweetener which are weighed in the sixth step into the primary mixture, uniformly mixing, sterilizing for 5min at the temperature of 121 ℃ by using an autoclave, adding the bifidobacterium bifidum weighed in the sixth step, and uniformly mixing to obtain a mixture;
seventhly, forming: and (3) uniformly dripping the mixture into the calcium lactate solution prepared in the fourth step by using a dropper with the diameter of 20mm to form liquid beads in the calcium lactate solution to obtain a liquid bead-containing calcium lactate solution, refrigerating the liquid bead-containing calcium lactate solution at the temperature of 4 ℃ for 1.2h, taking out the liquid beads, cleaning the liquid beads by using sterile distilled water, collecting the cleaned liquid beads, and carrying out vacuum packaging to obtain the edible sugar-free probiotic chewing gum popping bead solid mouthwash.
Example 1 deposit number of Bifidobacterium bifidum in step six: CICC 6168.
In the sixth step of the example 1, the mass fraction of the natural plant essential oil in the emulsion is 15%.
Example 1 in the sixth third step, the mass fraction of alginate gel in the primary mixture is 0.25%, and the mass fraction of sodium alginate is 1%.
Randomly extracting 50 subjects of different ages and different sexes, scraping oral bacteria of the tongue fur, the teeth, the upper and lower tooth chambers and the lip, the cheek, the gingival sulcus of the subjects by using an aseptic cotton swab to culture for 48 hours, then randomly dividing the subjects into two groups, eating 10-12 edible sugar-free probiotic oral fragrant bead solid mouthwash obtained in the embodiment 1 by using one group, gargling the other group by using clear water for about 5 minutes, then not taking any food and drinking water, scraping the oral bacteria of the same position of the subjects again to culture for 48 hours after 2 hours, and comparing.
TABLE 1
Identifying and screening the bacterial colonies in the table 1, determining the specific types of the bacterial colonies, and distinguishing beneficial bacteria, neutral bacteria and harmful bacteria, wherein the beneficial bacteria comprise streptococcus salivarius, lactobacillus rhamnosus, bifidobacterium, lactobacillus paracasei, prevotella intermedia, veillonella and the like; the neutral bacteria include Lactobacillus brevis, Lactobacillus reuteri, Staphylococcus, etc.; the harmful bacteria include Streptococcus A, Streptococcus mutans, oral coccus, and Actinomyces viscosus.
TABLE 2
As can be seen from tables 1 and 2, the reduction amount of the mouth wash is small, and the comparison of the colony ratios cannot be changed, but the edible sugar-free probiotic mouth-fragrant bead-blasting solid mouth wash provided by the invention can reduce the number of the colonies in the oral cavity and can also change the variety ratio of the colonies in the oral cavity beneficially.
Claims (10)
1. The edible sugar-free probiotic chewing gum bead-blasting solid mouthwash is characterized by comprising a solid wall and a liquid core, wherein the solid wall comprises sodium alginate, seaweed gel and calcium lactate, the liquid core comprises 10-20 parts by weight of natural plant essential oil, 0.5-1 part by weight of lemon grass extract, 1-2 parts by weight of mint extract, 0.5-1 part by weight of honeysuckle extract, 0.5-1 part by weight of bifidobacterium bifidum, 0.005-0.01 part by weight of cannabidiol and 3-5 parts by weight of sweetening agent, and the sweetening agent comprises fructo-oligosaccharide, D-xylose and thaumatin.
2. The edible sugar-free probiotic oral cavity flavor bead solid mouth wash according to claim 1, characterized in that the lemon grass extract is prepared by the following process:
cutting dry lemon grass, adding water to soak for 1-2 h, covering the lemon grass, heating to boil, decocting for 1-2 h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 5-8;
adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1-2 h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 1-3;
thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.5-1 h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 0.5-1.5;
and fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 15% -30% of the total liquid amount, and cooling and sterilizing to obtain the lemongrass extract.
3. The edible sugar-free probiotic oral flavor popping solid mouth wash according to claim 2, characterized in that the mint extract is prepared by the following process:
firstly, adding water into fresh mint, mixing and pulping, then adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35-40 ℃ for 12-14 h to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2-3; the mass ratio of the fresh mint to the pectinase is 100: 2-3;
secondly, performing supercritical extraction on the mint enzymolysis pulp, and performing ultrasonic extraction for 240-300 min under the conditions that the temperature is 60-70 ℃ and the power is 250-280W to obtain mint extracting solution;
and thirdly, freezing the mint extract, filtering, and then drying by microwave at the temperature of 112-118 ℃ and the power of 166-174W to obtain the mint extract.
4. The edible sugar-free probiotic oral flavor popping bead solid mouth wash as claimed in claim 3, characterized in that the honeysuckle extract is prepared by the following process:
firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in single extraction is 1: 10-15, and the single extraction time is 2-3 h;
secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate;
thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 40-75 ℃ until the solid content reaches more than 50%, obtaining a concentrated solution, and carrying out vacuum drying on the concentrated solution, thus obtaining the honeysuckle extract.
5. The edible sugar-free probiotic chewing gum popping solid mouthwash according to claim 4, characterized in that the cannabidiol is prepared according to the following process:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1-2 h at the temperature of 102-120 ℃, naturally cooling the industrial hemp powder to normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 40-60 ℃, and the pressure is 25-35 MPa; the flow rate of the carbon dioxide gas passing through the extraction kettle is 35L/h-45L/h, the extraction time is 1.5 h-2.5 h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heating furnace at 180-200 ℃ and the temperature of an auxiliary heat conduction furnace at 100-120 ℃, and collecting light component oil, wherein the vacuum degree of the molecular short-path distiller is 20-80 Pa, the rotation speed of the molecular short-path distiller is 100-200 r/min; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 1-2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 10% -50%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, performing isocratic elution for 60-80 min by using 50-80% ethanol solution, wherein the collection starting time is 10-15 min, and the collection finishing time is 50-70 min, thus obtaining the cannabidiol, wherein the THC content in the cannabidiol is less than 0.3%.
6. The edible sugar-free probiotic chewing gum popping bead solid mouthwash according to claim 5, characterized in that the bifidobacterium bifidum has the deposit number: CICC 6168.
7. The solid mouthwash according to claim 6, wherein the mass ratio of fructo-oligosaccharide to D-xylose in the sweetener is 1:2, and the mass ratio of fructo-oligosaccharide to thaumatin is 1: 0.5.
8. A preparation method of edible sugar-free probiotic chewing gum bead-blasting solid mouthwash is characterized by comprising the following steps:
firstly, preparing a lemon grass extract: cutting dry lemon grass, adding water to soak for 1-2 h, covering the lemon grass, heating to boil, decocting for 1-2 h with slow fire, and filtering to obtain primary filtrate and primary filter residue; the mass ratio of the dry lemon grass to the water is 1: 5-8; adding water into the primary filter residue, covering the filter residue, continuously heating to boil, decocting with slow fire for 1-2 h, and filtering to obtain secondary filtrate and secondary filter residue; the mass ratio of the primary filter residue to the water is 1: 1-3; thirdly, adding water into the secondary filter residue, covering the cover, continuing to heat to boil, decocting with slow fire for 0.5-1 h, and filtering to obtain a third filtrate and a third filter residue; the mass ratio of the secondary filter residue to the water is 1: 0.5-1.5; fourthly, combining the primary filtrate, the secondary filtrate and the tertiary filtrate to obtain lemongrass filtrate, heating and concentrating the lemongrass filtrate to 15% -30% of the total liquid amount, cooling and sterilizing to obtain a lemongrass extract;
secondly, preparing the mint extract: firstly, adding water into fresh mint, mixing and pulping, then adding cellulase and pectinase, mixing and stirring uniformly, and carrying out closed enzymolysis treatment at a constant temperature of 35-40 ℃ for 12-14 h to obtain mint enzymolysis pulp; the mass ratio of the fresh mint to the water is 1: 1; the mass ratio of the fresh mint to the cellulase is 100: 2-3; the mass ratio of the fresh mint to the pectinase is 100: 2-3; secondly, performing supercritical extraction on the mint enzymolysis pulp, and performing ultrasonic extraction for 240-300 min under the conditions that the temperature is 60-70 ℃ and the power is 250-280W to obtain mint extracting solution; thirdly, freezing the mint extract, filtering, and then drying by microwave under the conditions that the temperature is 112-118 ℃ and the power is 166-174W to obtain the mint extract;
thirdly, preparing a honeysuckle extract: firstly, crushing honeysuckle, sieving with a 50-mesh sieve to obtain honeysuckle powder, extracting the honeysuckle powder for three times by adopting water, and combining extracting solutions extracted for three times to obtain a honeysuckle extracting solution; the mass ratio of the honeysuckle powder to the water in single extraction is 1: 10-15, and the single extraction time is 2-3 h; secondly, centrifuging the honeysuckle extracting solution for 10min at the rotating speed of 15000r/min by adopting a disc centrifuge to obtain a centrifugate; thirdly, filtering the centrifugate by using a ceramic membrane, then carrying out reduced pressure concentration at the temperature of 40-75 ℃ until the solid content reaches more than 50% to obtain a concentrated solution, and carrying out vacuum drying on the concentrated solution to obtain a honeysuckle extract;
fourthly, preparing cannabidiol:
a. putting industrial hemp into a pulverizer to be pulverized into industrial hemp powder of 20-50 meshes, putting the industrial hemp powder into an oven, drying the industrial hemp powder for 1-2 h at the temperature of 102-120 ℃, naturally cooling the industrial hemp powder to normal temperature, putting the industrial hemp powder into a material barrel of a supercritical extraction kettle, injecting carbon dioxide gas into the extraction kettle to perform extraction, wherein the extraction temperature is 40-60 ℃, and the pressure is 25-35 MPa; the flow rate of the carbon dioxide gas passing through the extraction kettle is 35L/h-45L/h, the extraction time is 1.5 h-2.5 h, and an industrial hemp extraction intermediate is obtained;
b. putting an industrial hemp extraction intermediate into molecular distillation equipment for heating, melting at 70-90 ℃, pumping into a molecular short-path distiller when the industrial hemp extraction intermediate can flow, vacuumizing the molecular short-path distiller by a vacuum pump, controlling the temperature of a main heating furnace at 180-200 ℃ and the temperature of an auxiliary heat conduction furnace at 100-120 ℃, and collecting light component oil, wherein the vacuum degree of the molecular short-path distiller is 20-80 Pa, the rotation speed of the molecular short-path distiller is 100-200 r/min; carrying out molecular distillation on the heavy component oil obtained in the step b according to the operation process in the step b, repeating the operation for 1-2 times, and combining the collected light component oil to obtain an industrial hemp molecular distillation intermediate;
c. diluting the industrial hemp molecular distillation intermediate by using 95% ethanol in mass fraction to obtain a diluted industrial hemp molecular distillation intermediate, wherein the mass fraction of the industrial hemp molecular distillation intermediate in the diluted industrial hemp molecular distillation intermediate is 10% -50%; secondly, eluting effective components of the diluted industrial hemp molecular distillation intermediate in DAC dynamic preparative chromatography equipment, performing isocratic elution for 60-80 min by using 50-80% ethanol solution, wherein the collection starting time is 10-15 min, and the collection finishing time is 50-70 min to obtain the cannabidiol, wherein the THC content in the cannabidiol is less than 0.3%;
fifthly, preparing a calcium lactate solution: adding calcium lactate into water, dissolving for 0.5-1 h, sterilizing by using an autoclave, and cooling to room temperature to obtain a calcium lactate solution, wherein the mass fraction of calcium lactate in the calcium lactate solution is 3% -4%;
sixthly, mixing: weighing 10-20 parts of natural plant essential oil, 0.5-1 part of lemon grass extract, 1-2 parts of mint extract, 0.5-1 part of honeysuckle extract, 0.5-1 part of bifidobacterium bifidum, 0.005-0.01 part of cannabidiol and 3-5 parts of sweetener according to parts by weight; the sweetener comprises fructo-oligosaccharide, D-xylose and thaumatin; the mass ratio of fructo-oligosaccharide to D-xylose in the sweetener is 1: 2; the mass ratio of the fructo-oligosaccharide to the thaumatin is 1: 0.5; adding the natural plant essential oil weighed in the sixth step into water, and processing the natural plant essential oil into emulsion by using an emulsifying machine; thirdly, adding seaweed glue and sodium alginate into the emulsion, and homogenizing and uniformly mixing after completely dissolving to obtain a primary mixture; adding the lemongrass extract, the mint extract, the honeysuckle extract, the cannabidiol and the sweetener which are weighed in the sixth step into the primary mixture, uniformly mixing, sterilizing by using an autoclave, adding the bifidobacterium bifidum weighed in the sixth step, homogenizing and uniformly mixing to obtain a mixture;
seventhly, forming: and (3) uniformly dripping the mixture into the calcium lactate solution prepared in the fourth step by using a dropper with the diameter of 15-20 mm to form liquid beads in the calcium lactate solution to obtain a liquid bead-containing calcium lactate solution, refrigerating the liquid bead-containing calcium lactate solution at the temperature of 4 ℃ for 0.5-2 h, taking out the liquid beads, cleaning the liquid beads by using sterile distilled water, collecting the cleaned liquid beads, and carrying out vacuum packaging to obtain the edible sugar-free probiotic chewing gum bead-popping solid mouth wash.
9. The preparation method of the edible sugar-free probiotic oral fragrant bead-blasting solid mouth wash according to claim 8, characterized in that the natural plant essential oil in the emulsion of step five is 10-20% by weight; and fifthly, the mass fraction of the alginate gel in the primary mixture is 0.2-0.3%, and the mass fraction of the sodium alginate is 0.8-1.2%.
10. The preparation method of the edible sugar-free probiotic chewing gum bead-blasting solid mouthwash according to claim 9, is characterized in that the specific operation of the autoclave sterilization in the step IV and the step V is as follows: sterilizing with autoclave at 121 deg.C for 5 min.
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| CN114601011A (en) * | 2022-03-18 | 2022-06-10 | 阜阳师范大学 | Schizonepeta degradable chewing gum and preparation method thereof |
| CN114681355A (en) * | 2022-04-12 | 2022-07-01 | 广州桔子创新科技有限公司 | Mouthwash formula containing popping beads, production process and intelligent production equipment |
| CN114916600A (en) * | 2022-05-19 | 2022-08-19 | 陈杰 | Functional white kidney bean beverage and preparation method thereof |
| CN114983872A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Swallowable bead-blasting mouth wash with excellent blood compatibility and preparation method thereof |
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2021
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| CN114601011A (en) * | 2022-03-18 | 2022-06-10 | 阜阳师范大学 | Schizonepeta degradable chewing gum and preparation method thereof |
| CN114681355A (en) * | 2022-04-12 | 2022-07-01 | 广州桔子创新科技有限公司 | Mouthwash formula containing popping beads, production process and intelligent production equipment |
| CN114916600A (en) * | 2022-05-19 | 2022-08-19 | 陈杰 | Functional white kidney bean beverage and preparation method thereof |
| CN114983872A (en) * | 2022-05-30 | 2022-09-02 | 浙江大学 | Swallowable bead-blasting mouth wash with excellent blood compatibility and preparation method thereof |
| CN114983872B (en) * | 2022-05-30 | 2023-11-28 | 浙江大学 | Swallowing bead-bursting mouthwash with excellent blood compatibility and preparation method thereof |
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