CN111249197A - Traditional Chinese medicine composition containing nauclea officinalis and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition containing nauclea officinalis and preparation method and application thereof Download PDFInfo
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Abstract
The application belongs to the technical field of daily chemical articles, particularly relates to a traditional Chinese medicine composition containing nauclea officinalis and a preparation method and application thereof, and particularly relates to an oral care product with effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain and resisting bacteria. The traditional Chinese medicine composition containing the nauclea officinalis is prepared from 5-15 parts by weight of the nauclea officinalis, 10-15 parts by weight of pseudo-ginseng, 5-15 parts by weight of elecampane, 1-5 parts by weight of sophora fruit, 5-10 parts by weight of ligusticum wallichii and 1-5 parts by weight of rhizoma cimicifugae, has the effects of clearing heat and removing toxicity, diminishing inflammation and relieving pain and resisting bacteria, can inhibit the growth of harmful bacteria in the oral cavity and effectively prevent oral diseases. The traditional Chinese medicine composition containing the nauclea officinalis can be mixed with auxiliary materials and prepared into various oral care products by a conventional method.
Description
Technical Field
The invention belongs to the technical field of daily chemical articles, particularly relates to a traditional Chinese medicine composition containing nauclea officinalis and a preparation method and application thereof, and particularly relates to an oral care product with the effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain and resisting bacteria.
Background
The oral hygiene products are indispensable cleaning and health care products in daily life of people, and the products have various types, such as toothpaste, mouthwash, chewing gum and the like, and are mainly used for keeping the oral cavity and teeth clean, promoting breath freshness, nursing gingiva and maintaining good environment of the oral cavity. For example, toothpaste is a common cleaning product in daily life, has a long history, can clean substances on the surfaces of teeth, and has the effects of rubbing, removing bacterial plaque, cleaning and polishing the surfaces of teeth and refreshing the oral cavity. In recent years, as consumers seek natural and safe requirements and with the continuous development of scientific technology and the continuous improvement and perfection of technological equipment, various oral hygiene products come out and the quality and grade of the products are continuously improved. With the increasing awareness of consumer health care, toothpaste is required to have excellent tooth cleaning function, and more oral care health care needs, such as auxiliary prevention or treatment of oral diseases, are also proposed. The demand for various functional products in the toothpaste market is increasing and has become the mainstream of the market. Not only can clean the substances on the surface of teeth to refresh the mouth, but also can reduce dental plaque through the action of the medicines added in the substances, and some of the substances have the effects of resisting inflammation, relieving pain, and preventing dental caries and periodontal disease.
The current functional oral care product has the choice of adding tranexamic acid to it, but after adding tranexamic acid, it will make the gingiva produce antibodies, and tranexamic acid is a prescribed drug. This necessarily increases the production cost of the toothpaste and the risk of using raw materials. The traditional Chinese medicine is a treasure of Chinese nation, has rich resources, long history and huge development potential, and is widely concerned by scholars at home and abroad. At present, the traditional Chinese medicine tooth care mode is mainly to add the extract of the traditional Chinese medicine into oral care products such as toothpaste, mouthwash, chewing gum and the like. Oral care products containing Chinese herbal medicines are deeply favored by consumers due to the characteristics of natural functional additives, obvious effect, high safety and the like. In recent years, a plurality of Chinese herbal medicine oral care products are on the market, but the traditional Chinese medicine efficacy of most products is not outstanding, and the prepared toothpaste has single efficacy.
Disclosure of Invention
In view of the above, the present invention aims to provide an oral care product with heat-clearing and detoxifying, anti-inflammatory and analgesic, and antibacterial effects.
In order to realize the purpose of the invention, the invention adopts the following technical scheme:
a Chinese medicinal composition comprises lignum naucleae 5-15 weight parts, Notoginseng radix 10-15 weight parts, radix aucklandiae 5-15 weight parts, fructus Sophorae 1-5 weight parts, rhizoma Ligustici Chuanxiong 5-10 weight parts, and cimicifugae rhizoma 1-5 weight parts.
The traditional Chinese medicine composition containing the nauclea officinalis has the effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain and resisting bacteria, can inhibit the growth of harmful bacteria in the oral cavity and effectively prevents oral diseases.
Wherein the lignum naucleae is branches and barks of Pinus marsupium Nauclea of Filicinalis Pierre. The raw materials are mostly split into irregular slices and blocks which are light yellow or brownish yellow, and the skins of the irregular slices and blocks are brownish yellow, coarse, loose and easy to strip. The cross section skin part is dark brown, and the wood part is yellow or dark yellow. Hard, light smell, bitter taste. The color is bright yellow and the taste is bitter. Has the effects of clearing away heat and toxic materials, relieving swelling and pain, and inhibiting bacteria.
Radix aucklandiae is root of Compositae plant radix aucklandiae, and is cylindrical or flat cylindrical. Strong and specific smell, sweet first and bitter later, slight tongue prickling. Mainly used for promoting the circulation of qi and relieving pain; to regulate the middle energizer and remove food stagnation. Hypochondriac distention in the main cell is satisfied; abdominal distending pain; belching, vomiting and diarrhea; severe after dysentery. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia; the middle-jiao energy is not saved; sudden deafness; biting by snake and insect; toothache.
Notoginseng radix is dried root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae. Has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain. It can be used for treating hemorrhage, traumatic injury, and swelling and pain due to blood stasis.
Fructus Sophorae is fruit of Sophora japonica L. After autumn, the ripe fruits are picked, cleaned, dried in the sun and unprocessed. Contains sophoricoside. Michellin, rutin, sophorafenone glycoside, mangiferin, sophorol and oleic acid. Has toxic materials clearing away, anticancer, blood cooling, hemostatic, antiinflammatory, and repercussive effects.
Rhizoma Ligustici Chuanxiong is dried rhizome of Ligusticum chuanhianxiong Hort of Umbelliferae. Has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. It can be used for treating pain due to blood stasis and qi stagnation, headache, and arthralgia due to wind-dampness.
Cimicifuga foetida is a rhizome of Cimicifuga acerola Kom, Cimicifuga ladurica (Turez.) Maxim. or Cimicifuga Acetoetida L. belonging to Ranunculaceae. Has the effects of relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang qi. It can be used for treating exterior syndrome due to exogenous pathogenic factors, measles without adequate eruption, toothache, aphtha, sore throat, warm toxic, macula, qi deficiency collapse, organ prolapse, metrorrhagia, and metrostaxis.
In some embodiments, the traditional Chinese medicine composition of the present invention is prepared from 10 parts by weight of nauclea officinalis, 12 parts by weight of panax notoginseng, 10 parts by weight of elecampane, 3 parts by weight of sophora fruit, 7 parts by weight of ligusticum wallichii, and 3 parts by weight of cimicifuga foetida.
The invention also provides a preparation method of the traditional Chinese medicine composition. Weighing lignum naucleae, pseudo-ginseng, elecampane, fructus sophorae, ligusticum wallichii and rhizoma cimicifugae in parts by weight, adding 70 w/w% ethanol solution according to the proportion of 1: 8-10, sealing and soaking for 20-30 minutes, then carrying out ultrasonic treatment for 30-60 minutes at the frequency of 50HZ, removing medicine residues to obtain a traditional Chinese medicine extracting solution, and carrying out reduced pressure distillation to remove ethanol to obtain the traditional Chinese medicine.
Wherein the total weight of the Nauclea officinalis, the pseudo-ginseng, the costustoot, the sophora fruit, the ligusticum wallichii and the cimicifuga foetida is 1 part by weight, and the 70 w/w% ethanol solution is 8-10 parts by weight, namely, the 70 w/w% ethanol solution is 8-10 times of the total weight of the Nauclea officinalis, the pseudo-ginseng, the costustoot, the sophora fruit, the ligusticum wallichii and the cimicifuga foetida.
In some embodiments, the preparation method comprises weighing lignum naucleae, radix notoginseng, radix aucklandiae, fructus sophorae, rhizoma ligustici wallichii and rhizoma cimicifugae in parts by weight, placing the materials in an ultrasonic instrument, adding 70 w/w% ethanol solution according to the proportion of 1: 10, covering a cover, soaking for 30 minutes, then opening the ultrasonic instrument with the frequency of 50HZ for treating for 40 minutes, discarding medicine residues to obtain a traditional Chinese medicine extracting solution, and distilling under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extracting solution.
In some specific embodiments, the nauclea officinalis, the pseudo-ginseng, the costus root, the sophora fruit, the ligusticum wallichii and the cimicifuga foetida are selected for compounding, on one hand, the compounded composition can generate a synergistic effect of inhibiting Streptococcus mutans (Streptococcus mutans), and on the other hand, the screened traditional Chinese medicine composition has no significant inhibition effect on Streptococcus salivarius (Streptococcus salivarius), so that the flora balance of an oral cavity can be maintained to the maximum extent; on the other hand, the compound composition has the effects of promoting qi and blood circulation, dispelling wind and eliminating dampness, and cooling blood and stopping bleeding, and the medicines can play a good role in treating the periodontal disease when being used together. Therefore, the invention provides the application of the nauclea officinalis-containing traditional Chinese medicine composition in preparing products with the effects of clearing heat and removing toxicity, diminishing inflammation, relieving pain and resisting bacteria.
In the present invention, the product is an oral care product.
Further, the oral care products include, but are not limited to, toothpastes, mouthwashes, chewing gums.
The invention also provides an oral care product which comprises the traditional Chinese medicine composition containing the nauclea officinalis and auxiliary materials.
Those skilled in the art can directly or indirectly add the above traditional Chinese medicinal composition containing lignum naucleae into various required common adjuvants, and make into conventional oral care products such as toothpaste, collutory, and chewing gum by conventional method.
The invention also provides toothpaste which comprises the following raw materials in percentage by weight: 10-20% of the traditional Chinese medicine composition containing the nauclea officinalis, 0.01-0.2% of paeonol, 20-30% of glycerol, 2-3% of lauroyl-N-methyl sodium glycinate, 30-40% of calcium hydrophosphate dihydrate, 10-20% of expanded perlite, 1-2% of sodium carboxymethylcellulose, 0.1-0.2% of saccharin, 0.5-1% of clove oil, 0.01-0.15% of tetrahydropalmatine, 0.1-0.5% of sodium benzoate and 3-5% of purified water; the sum of the weight percentages of the raw materials is equal to 100 percent.
The toothpaste has the effects of clearing heat and removing toxicity, diminishing inflammation, relieving pain and resisting bacteria, can efficiently resist various oral pathogenic bacteria, prevent oral diseases such as periodontitis, gingivitis and the like, can comprehensively care the oral cavity and protect the health of the oral cavity and teeth.
Further, the toothpaste provided by the invention comprises the following raw materials in percentage by weight: 15% of the traditional Chinese medicine composition containing the nauclea officinalis, 0.1% of paeonol, 25% of glycerol, 3% of lauroyl-N-methyl sodium glycinate, 35% of calcium hydrophosphate dihydrate, 15% of expanded perlite, 1.25% of sodium carboxymethylcellulose, 0.2% of saccharin, 1% of clove oil, 0.05% of tetrahydropalmatine, 0.5% of sodium benzoate and 4% of purified water.
Further, the invention also provides a preparation method of the toothpaste, which comprises the following steps of weighing the raw materials in percentage by weight; uniformly mixing the weighed traditional Chinese medicine composition with purified water, then adding sodium carboxymethylcellulose, standing overnight, and dissolving the sodium carboxymethylcellulose after complete swelling; adding paeonol, glycerol, oleum Caryophylli, tetrahydropalmatine, lauroyl-N-methyl sodium glycinate, saccharin and sodium benzoate, stirring to dissolve, adding calcium hydrogen phosphate dihydrate and expanded perlite, and stirring for 24 hr in a stirrer to obtain a paste with certain viscosity and appropriate thickness.
Compared with the prior art, the invention has at least one of the following advantages:
1. the traditional Chinese medicine composition is prepared by compounding nauclea officinalis, pseudo-ginseng, elecampane, sophora fruit, ligusticum wallichii and cimicifuga foetida, the components are compounded to generate a synergistic effect of inhibiting Streptococcus mutans (Streptococcus mutans), no obvious inhibition effect is generated on Streptococcus salivarius (Streptococcus salivarius), and the flora balance of the oral cavity can be maintained to the maximum extent. Meanwhile, the traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain and resisting bacteria, and can play a good role in treating periodontal diseases.
2. The traditional Chinese medicine composition is extracted by an ultrasonic extraction method, and the extraction rate and the extraction efficiency of the effective components of the traditional Chinese medicine are improved by the ultrasonic mechanical vibration performance and the strong cavitation effect.
3. The toothpaste has the effects of clearing heat, removing toxicity and resisting inflammation, and simultaneously takes the expanded perlite and the calcium hydrophosphate dihydrate as an abrasive. The use of the expanded perlite is beneficial to improving the cleaning effect of the toothpaste, has better polishing effect, and can polish the concave-convex surface caused by color spots, bacterial plaque or fine tartar on the surface of the tooth to achieve the purpose of polishing and whitening. Calcium hydrogen phosphate dihydrate is a mild abrasive, has affinity with enamel and has moderate friction on the enamel. The expanded perlite and the calcium hydrogen phosphate dihydrate are matched for use, so that the tooth cleaning effect is good, tooth enamel is not damaged, and the tooth cleaning and polishing can be realized while the abrasion of toothpaste on the teeth is reduced.
Detailed Description
The invention discloses a traditional Chinese medicine composition containing nauclea officinalis and a preparation method and application thereof. Those skilled in the art can modify the process parameters appropriately to achieve the desired results with reference to the disclosure herein. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and products of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications of the methods described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of the present invention without departing from the spirit and scope of the invention.
In order to further understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Unless otherwise specified, the reagents involved in the examples of the present invention are all commercially available products, and all of them are commercially available.
Example 1 preparation of a Chinese medicinal composition
Placing 10 parts by weight of Nauclea officinalis, 12 parts by weight of pseudo-ginseng, 10 parts by weight of costus root, 3 parts by weight of sophora fruit, 7 parts by weight of ligusticum wallichii and 3 parts by weight of cimicifuga foetida in an ultrasonic instrument, adding 70 w/w% ethanol solution according to the weight ratio of 1: 10, covering a cover, soaking for 30 minutes, then opening the ultrasonic instrument with the frequency of 50HZ for treating for 40 minutes, discarding medicine residues to obtain a traditional Chinese medicine extracting solution, and placing the traditional Chinese medicine extracting solution in a reduced pressure distiller to evaporate ethanol to obtain the traditional Chinese medicine composition.
Example 2 preparation of a Chinese medicinal toothpaste having heat and toxic materials clearing away, anti-inflammatory, analgesic, and antibacterial effects
(1) Weighing the raw materials according to the following weight percentage;
15% of the traditional Chinese medicine composition, 0.1% of paeonol, 25% of glycerol, 3% of lauroyl-N-methyl sodium glycinate, 35% of calcium hydrophosphate dihydrate, 15% of expanded perlite, 1.25% of sodium carboxymethylcellulose, 0.2% of saccharin, 1% of clove oil, 0.05% of tetrahydropalmatine, 0.5% of sodium benzoate and 4% of purified water;
(2) uniformly mixing the weighed traditional Chinese medicine composition with purified water, then adding sodium carboxymethylcellulose, standing overnight, and dissolving the sodium carboxymethylcellulose after complete swelling;
(3) and (3) adding paeonol, glycerol, clove oil, tetrahydropalmatine, lauroyl-N-methyl sodium glycinate, saccharin and sodium benzoate into the solution obtained in the step (2), stirring to dissolve the paeonol, the glycerol, the clove oil, the tetrahydropalmatine, the lauroyl-N-methyl sodium glycinate, the saccharin and the sodium benzoate, adding calcium hydrophosphate dihydrate and the expanded perlite, stirring for 24 hours in a stirrer until the calcium hydrophosphate and the expanded perlite are uniformly mixed to obtain a thick and thin paste with certain viscosity, and filling and packaging after quality inspection is qualified.
Test example 1 bacteriostatic test
1. Preparation of Chinese medicinal extract
Preparation of traditional Chinese medicine extract powder 1: placing 10 parts by weight of Nauclea officinalis, 12 parts by weight of pseudo-ginseng, 10 parts by weight of costus root, 3 parts by weight of sophora fruit, 7 parts by weight of ligusticum wallichii and 3 parts by weight of cimicifuga foetida in an ultrasonic instrument, adding 70 w/w% ethanol solution according to the weight ratio of 1: 10, covering a cover, soaking for 30 minutes, then opening the ultrasonic instrument for 40 minutes, removing medicine residues to obtain a traditional Chinese medicine extracting solution, placing the traditional Chinese medicine extracting solution in a reduced pressure distiller to evaporate ethanol to obtain a traditional Chinese medicine extracting solution 1, and performing spray drying to obtain dry powder of the traditional Chinese medicine extracting solution, namely the traditional Chinese medicine extract powder 1.
Preparing traditional Chinese medicine extract powder 2-7: respectively preparing 45 parts by weight of Nauclea officinalis, Panax notoginseng, radix aucklandiae, fructus Sophorae, rhizoma Chuanxiong and rhizoma cimicifugae into Chinese medicinal extractive solution 2-7 containing only single Chinese medicinal material according to the preparation method of Chinese medicinal extractive solution 1, and spray drying to obtain dry powder of each Chinese medicinal extractive solution, i.e. Chinese medicinal extract powder 2-7.
2. Preparation of plate containing bacteria
The test bacteria are Streptococcus mutans (ATCC 25923), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC76615), and Streptococcus salivarius (ATCC 19258).
Respectively culturing the above test bacteria, diluting with sterile normal saline to obtain test bacteria suspension with bacteria content of 1 × 108cfu/ml. Respectively mixing 1ml of each bacterial suspension, 0.2ml of calf serum and 15ml of melted beef soup culture medium, making into plate containing bacteria, and condensing for use. Candida albicans was plated on sandcastle medium.
3. Bacteriostasis test
Qualitative filter paper is taken and made into 6mm diameter circular slices, and pressure steam sterilization is carried out. Then diluting the Chinese medicinal extract powder with medical normal saline to obtain different concentrations (1: 10, 1: 50, 1: 100, 1: 200, 1: 400, 1: 800, 1: 1600, 1: 3200, 1: 6400). And (3) sticking filter paper sheets on the surface of the prepared bacteria-containing culture medium, wherein the distance between the paper sheets and the edges of the flat plates is 15mm, and 4-6 filter paper sheets are stuck on each flat plate. Accurately taking 10 μ l of each Chinese medicinal extractive solution with 10 dilutions, and sequentially adding into each filter paper sheet. And (3) culturing the plate after adding the medicine at 37 ℃ for 24h, culturing the candida albicans plate at 37 ℃ for 48h, and accurately measuring the diameter of the bacteriostatic ring, wherein the dilution multiple corresponding to the diameter of the bacteriostatic ring being less than 7mm is considered as the minimum bacteriostatic concentration. The results are shown in table 1 below.
TABLE 1 minimum inhibitory concentration of each Chinese medicinal extract
| Streptococcus mutans | Staphylococcus aureus | Candida albicans | Salivary streptococcus | |
| Chinese medicine extract 1 | 1:3000 | 1:3000 | 1:1500 | 1:750 |
| Chinese medicine extract 2 | 1:2800 | 1:2800 | 1:800 | 1:600 |
| Chinese medicine extract 3 | 1:2500 | 1:2000 | 1:600 | 1:600 |
| Chinese medicinal extract 4 | 1:800 | 1:800 | 1:800 | 1:700 |
| Chinese medicine extract 5 | 1:1000 | 1:1500 | 1:1000 | 1:650 |
| Chinese medicinal extract 6 | 1:1500 | 1:1000 | 1:800 | 1:600 |
| Chinese medicine extract 7 | 1:1500 | 1:1500 | 1:750 | 1:1500 |
From the results, the traditional Chinese medicine extract powder compounded by the invention has better effect of inhibiting streptococcus mutans, staphylococcus aureus and candida albicans compared with the traditional Chinese medicine extract powder obtained by single medicine.
Test example 2 anti-inflammatory effect of the traditional Chinese medicine toothpaste on acute inflammation swelling of auricular corridor of mice caused by xylene
1. Experimental Material
Test sample 1: toothpaste 1, prepared according to the method of example 2
Test sample 2: toothpaste 2, prepared according to the method of example 2, but without the traditional Chinese medicine composition, the corresponding part was replaced with purified water;
test sample 3: toothpaste 3, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the nauclea officinalis extract of a single medicine;
test sample 4: toothpaste 4, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the pseudo-ginseng extract of a single medicine;
test sample 5: toothpaste 5, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the extract of costus root of a single medicine;
test sample 6: toothpaste 6, prepared according to the method of example 2, in which the traditional Chinese medicine composition was replaced with the extract of the fructus sophorae of the single medicine;
test sample 7: toothpaste 7, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the extract of the single herb of chuanxiong rhizome;
test sample 8: toothpaste 8, prepared according to the method of example 2, in which the traditional Chinese medicine composition was replaced with cimicifugae foetidae extract of a single drug;
the extracts of the individual drugs were prepared according to the method of test example 1.
2. Method and results
80 healthy Kunming male mice were selected and randomly divided into 8 groups of 10 mice each. In the experiment, 0.1ml of dimethylbenzene is smeared on the inner and outer surfaces of the right ear corridor of each animal in each group until inflammation occurs, and the left ear is not treated to be used as a self blank control group. After being coated with dimethylbenzene for 30min, the inner and outer surfaces of the right ear corridor of each animal in each group are respectively and uniformly coated with 0.1 g/animal of each group of test samples. After the test object is given for 1h, the white mouse is killed by dislocation of the cervical vertebra, the two ear galleries are cut off, a sample of the test object of the right ear gallery is washed off by normal saline, a dry cotton ball is used for wiping, two round lugs are chiseled at the same part by a puncher, and the weight of the right lug minus the weight of the left lug is taken as a swelling value. The results are shown in Table 2. All data were statistically analyzed using SPSS19.0 statistical software, and the data were expressed as means. + -. standard deviation (x. + -.s).
TABLE 2 anti-inflammatory effect on acute inflammation swelling of auricularia of mice induced by paraxylene
As can be seen from the table 2, the traditional Chinese medicine toothpaste provided by the invention can obviously reduce the quality of acute inflammation swelling auricular corridor of a white mouse, and obviously inhibit acute inflammation swelling of the auricular corridor of the white mouse caused by xylene, so that the traditional Chinese medicine toothpaste provided by the invention has an obvious anti-inflammatory effect on acute inflammation. Compared with a test object only containing one traditional Chinese medicine, the toothpaste containing the compounded traditional Chinese medicine extracting solution has a more remarkable improvement effect on acute inflammation and swelling of the auricular corridor of the mice caused by xylene, and the fact that all components in the traditional Chinese medicine composition have a remarkable synergistic promotion effect in the aspect of anti-inflammation is demonstrated.
Test example 3 the analgesic effect of the Chinese medicinal toothpaste of the present invention was examined by the hot plate method
1. Experimental Material
Test sample 1: toothpaste 1, prepared according to the method of example 2
Test sample 2: toothpaste 2, prepared according to the method of example 2, but without the traditional Chinese medicine composition, the corresponding part was replaced with purified water;
test sample 3: toothpaste 3, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the nauclea officinalis extract of a single medicine;
test sample 4: toothpaste 4, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the pseudo-ginseng extract of a single medicine;
test sample 5: toothpaste 5, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the extract of costus root of a single medicine;
test sample 6: toothpaste 6, prepared according to the method of example 2, in which the traditional Chinese medicine composition was replaced with the extract of the fructus sophorae of the single medicine;
test sample 7: toothpaste 7, prepared according to the method of example 2, in which the traditional Chinese medicine composition is replaced by the extract of the single herb of chuanxiong rhizome;
test sample 8: toothpaste 8, prepared according to the method of example 2, in which the traditional Chinese medicine composition was replaced with cimicifugae foetidae extract of a single drug;
the extracts of the individual drugs were prepared according to the method of test example 1.
2. Method and results
90 healthy Kunming male mice are selected and randomly divided into 9 groups of 10 mice. The blank control group is administrated with 0.4ml of distilled water by stomach irrigation, other experimental groups are administrated with 0.4ml by stomach irrigation, the mouse is placed on a hot plate with a certain temperature, and the foot of the mouse is thermally stimulated to generate pain response, namely, licking response. And (3) judging whether the test sample has the analgesic effect or not by taking the time effect of the mouse licking as the pain response index. The results are shown in Table 3.
TABLE 3 results of analgesic action
| Group of | Time effect |
| Blank control group | 2min |
| Test sample 1 group | 25min |
| Test sample 2 group | 4min |
| Test sample 3 groups | 16min |
| Test sample 4 groups | 6min |
| Test sample 5 groups | 10min |
| Test sample 6 groups | 8min |
| Test sample 7 groups | 12min |
| Test sample 8 groups | 5min |
As can be seen from Table 3, the traditional Chinese medicine toothpaste provided by the invention can obviously weaken the pain feeling of mice, and shows that the traditional Chinese medicine toothpaste provided by the invention has an obvious analgesic effect. Compared with a test object only containing one traditional Chinese medicine, the toothpaste containing the compounded traditional Chinese medicine extracting solution has a remarkable analgesic effect.
In conclusion, the toothpaste prepared from the traditional Chinese medicine composition has the effects of bacteriostasis, anti-inflammation and analgesia.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A Chinese medicinal composition comprises lignum naucleae 5-15 weight parts, Notoginseng radix 10-15 weight parts, radix aucklandiae 5-15 weight parts, fructus Sophorae 1-5 weight parts, rhizoma Ligustici Chuanxiong 5-10 weight parts, and cimicifugae rhizoma 1-5 weight parts.
2. The Chinese medicinal composition according to claim 1, which is prepared from 10 parts by weight of Nauclea officinalis, 12 parts by weight of Panax notoginseng, 10 parts by weight of Aucklandia lappa, 3 parts by weight of Sophora japonica, 7 parts by weight of Ligusticum chuanxiong, and 3 parts by weight of Cimicifuga foetida.
3. The preparation method of the Chinese medicinal composition according to claim 1 or 2, weighing lignum naucleae, radix notoginseng, radix aucklandiae, fructus sophorae, rhizoma ligustici wallichii and rhizoma cimicifugae in parts by weight, adding 70 w/w% ethanol solution in a ratio of 1: 8-10, sealing and soaking for 20-30 minutes, then treating for 30-60 minutes by using 50HZ ultrasonic, discarding residues to obtain a Chinese medicinal extract, and distilling under reduced pressure to remove ethanol to obtain the Chinese medicinal composition.
4. The use of the composition of claim 1 or 2 for the preparation of a product having heat and toxic material clearing, anti-inflammatory, analgesic, and antibacterial effects.
5. The use according to claim 4, wherein the product is an oral care product.
6. The use according to claim 5, wherein the oral care product is a toothpaste, a mouthwash, a chewing gum.
7. An oral care product comprising the traditional Chinese medicine composition of any one of claims 1-2 and an adjuvant.
8. The toothpaste comprises the following raw materials in percentage by weight:
10-20% of the traditional Chinese medicine composition of any one of claims 1-2, 0.01-0.2% of paeonol, 20-30% of glycerol, 2-3% of sodium lauroyl-N-methyl aminoacetate, 30-40% of calcium hydrophosphate dihydrate, 10-20% of expanded perlite, 1-2% of sodium carboxymethylcellulose, 0.1-0.2% of saccharin, 0.5-1% of clove oil, 0.01-0.15% of tetrahydropalmatine, 0.1-0.5% of sodium benzoate and 3-5% of purified water; the sum of the weight percentages of the raw materials is equal to 100 percent.
9. The toothpaste as claimed in claim 8, which comprises the following raw materials in percentage by weight: the Chinese medicinal composition of any one of claims 1-2, 15% of paeonol, 0.1% of glycerol, 25% of sodium lauroyl-N-methylcarbamate, 3% of calcium hydrogen phosphate dihydrate, 15% of expanded perlite, 1.25% of sodium carboxymethylcellulose, 0.2% of saccharin, 1% of clove oil, 0.05% of tetrahydropalmatine, 0.5% of sodium benzoate and 4% of purified water.
10. The preparation method of the toothpaste as claimed in claim 8 or 9, weighing the raw materials according to the weight percentage; uniformly mixing the weighed traditional Chinese medicine composition with purified water, then adding sodium carboxymethylcellulose, standing overnight, and dissolving the sodium carboxymethylcellulose after complete swelling; adding paeonol, glycerol, oleum Caryophylli, tetrahydropalmatine, lauroyl-N-methyl sodium glycinate, saccharin and sodium benzoate, stirring to dissolve, adding calcium hydrogen phosphate dihydrate and expanded perlite, and stirring for 24 hr in a stirrer to obtain a paste with certain viscosity and appropriate thickness.
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| CN113398040A (en) * | 2021-08-07 | 2021-09-17 | 兰州市食品药品检验检测研究院 | Mouthwash as well as preparation method and use method thereof |
| CN115137774A (en) * | 2022-07-06 | 2022-10-04 | 海南医学院 | Application of nauclea officinalis leaf extract in preparation of anti-candida krusei medicament |
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| CN110448496A (en) * | 2019-09-14 | 2019-11-15 | 浙江爱尚日用品有限公司 | A kind of Chinese medicinal toothpaste composition and preparation method thereof with anti-inflammatory, antiallergic sense and analgesic effect |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110448496A (en) * | 2019-09-14 | 2019-11-15 | 浙江爱尚日用品有限公司 | A kind of Chinese medicinal toothpaste composition and preparation method thereof with anti-inflammatory, antiallergic sense and analgesic effect |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398040A (en) * | 2021-08-07 | 2021-09-17 | 兰州市食品药品检验检测研究院 | Mouthwash as well as preparation method and use method thereof |
| CN115137774A (en) * | 2022-07-06 | 2022-10-04 | 海南医学院 | Application of nauclea officinalis leaf extract in preparation of anti-candida krusei medicament |
| CN115137774B (en) * | 2022-07-06 | 2023-08-11 | 海南医学院 | Application of lignum sappan leaf extract in preparing anti-candida krusei medicine |
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