CN113546029A

CN113546029A - Oral antibacterial toothpaste with functions of diminishing inflammation and removing halitosis

Info

Publication number: CN113546029A
Application number: CN202110795953.1A
Authority: CN
Inventors: 桑苏君
Original assignee: Beijing Shengyong Pharmaceutical Co ltd
Current assignee: Beijing Shengyong Pharmaceutical Co ltd
Priority date: 2021-07-14
Filing date: 2021-07-14
Publication date: 2021-10-26

Abstract

The invention discloses oral bacteriostatic toothpaste with functions of diminishing inflammation and removing halitosis, which comprises a bacteriostatic composition, wherein the mass percent of the bacteriostatic composition in the oral bacteriostatic toothpaste is 1-5%; the antibacterial composition comprises plant extracts, lysozyme, lactoferrin and propolis; the plant extract comprises eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract; according to the invention, the lactoferrin, the lysozyme, the eucalyptus oil, the pistacia chinensis bunge extract and the like are added into the formula of the oral bacteriostatic toothpaste, so that the oral bacteriostatic toothpaste has a good bacteriostatic effect, particularly has an obvious effect on inhibiting common harmful bacteria in oral cavities such as escherichia coli, staphylococcus aureus, streptococcus mutans and the like, further eliminates oral inflammation and effectively removes halitosis.

Description

Oral antibacterial toothpaste with functions of diminishing inflammation and removing halitosis

Technical Field

The invention relates to an oral bacteriostatic toothpaste, in particular to an oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis.

Background

With the continuous improvement of the living standard quality of people, the rhythm of life of people is faster and faster, work remuneration or relatives and friends gathering becomes a very common thing, and peculiar smell of the oral cavity becomes a trouble in interpersonal communication. People who pay no attention to oral cleaning for a long time, the growth of streptococcus mutans in the oral cavity is easy to grow in residual food contained in the oral cavity, the residual food is easy to ferment into harmful dental plaque acid, and finally dental caries is caused. In persons suffering from oral diseases such as dental caries, gingivitis, periodontitis, oral mucositis, and dental caries and periodontal disease, bacteria, especially anaerobic bacteria, are easily grown in the oral cavity, and the bacteria are decomposed to produce sulfides, giving off putrefactive taste, and causing halitosis.

Therefore, the development of an oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis is urgently needed.

Disclosure of Invention

The invention aims to provide an oral bacteriostatic toothpaste with functions of diminishing inflammation and removing halitosis, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

an oral bacteriostatic toothpaste with anti-inflammatory and halitosis-removing functions comprises a bacteriostatic composition, wherein the mass percentage of the bacteriostatic composition in the oral bacteriostatic toothpaste is 1-5%;

the antibacterial composition comprises plant extracts, lysozyme, lactoferrin and propolis;

the plant extract comprises eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract;

the eucalyptus oil, the pistacia chinensis bunge extract, the honeysuckle extract, the dendrobium officinale extract, the liquorice extract, the isatis root extract, the forsythia suspense extract and the bletilla striata extract are in a ratio of 5-15:5-12:8-18:6-15:10-20:5-12:3-8: 3-8.

As a further scheme of the invention: the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 1-10:1-8:1-7: 1-5.

As a further scheme of the invention: the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 4-8:3-6:2-5: 3-5.

As a further scheme of the invention: the oral bacteriostatic toothpaste also comprises an abrasive, a humectant, a foaming agent and a flavoring agent.

As a further scheme of the invention: the weight percentage of the abrasive is 15-60%, the weight percentage of the humectant is 20-70%, the weight percentage of the foaming agent is 0.5-3%, and the weight percentage of the flavoring agent is 0.1-2%.

As a further scheme of the invention: the components of the abrasive are one or the combination of hydrated silica and calcium hydrophosphate.

As a further scheme of the invention: the humectant comprises one or a combination of sorbitol, propylene glycol and glycerol.

As a further scheme of the invention: the foaming agent is sodium lauryl sulfate.

As a further scheme of the invention: the flavoring agent comprises one or more of menthol, essence and xylitol.

As a still further scheme of the invention: the preparation method of the oral bacteriostatic toothpaste comprises the following steps:

s1: weighing the plant extract, lysozyme, lactoferrin, propolis, an abrasive, a humectant, a foaming agent and a flavoring agent according to the formula ratio;

s2: placing the plant extract, lysozyme, lactoferrin, propolis, an abrasive and a humectant into a paste making machine, and uniformly stirring while keeping the vacuum between-0.05 Mpa and-0.080 Mpa;

s3: putting the foaming agent and the flavoring agent into a paste making machine, and stirring uniformly while keeping the vacuum between-0.05 Mpa and-0.080 Mpa;

s4: degassing the paste making machine until the vacuum degree is-0.093 Mpa to-0.095 Mpa, and discharging to obtain the oral antibacterial toothpaste.

Compared with the prior art, the invention has the beneficial effects that:

according to the invention, the lactoferrin, the lysozyme, the eucalyptus oil, the pistacia chinensis bunge extract and the like are added into the formula of the oral bacteriostatic toothpaste, so that the oral bacteriostatic toothpaste has a good bacteriostatic effect, particularly has an obvious effect on inhibiting common harmful bacteria in oral cavities such as escherichia coli, staphylococcus aureus, streptococcus mutans and the like, further eliminates oral inflammation and effectively removes halitosis.

According to the invention, the forsythia extract, the bletilla striata extract and the like are added into the formula of the oral bacteriostatic toothpaste, so that the oral bacteriostatic toothpaste has good effects of clearing heat, detoxifying, reducing swelling, relieving pain, preventing wound infection and the like, and can effectively improve the oral problems.

Detailed Description

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention will be further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis comprises a bacteriostatic composition, wherein the mass percent of the bacteriostatic composition in the oral bacteriostatic toothpaste is 1-5%;

the lysozyme is an alkaline enzyme capable of hydrolyzing mucopolysaccharide in bacteria, and can decompose insoluble mucopolysaccharide in cell walls into soluble glycopeptides by destroying beta-1, 4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in the cell walls, so that cell wall rupture contents escape to dissolve the bacteria, and can be directly combined with virus proteins with negative charges to form complexes with DNA, RNA and apoprotein to inactivate viruses, and lysozyme is added into toothpaste to effectively kill most harmful bacteria in oral cavity and inhibit the breeding of the harmful bacteria.

Lactoferrin has strong biological functions of broad-spectrum antibiosis, antioxidation, anticancer, immune system regulation and the like, is considered as a novel antibacterial and anticancer medicine, and can effectively inhibit breeding of harmful bacteria in oral cavity by adding lactoferrin into toothpaste.

The propolis is in the form of block or irregular fragment, and is in the forms of greenish, brown yellow, red, brown or dark brown, and has luster on surface or section. Gradually becomes hard and brittle below 20 ℃, gradually becomes soft at 20-40 ℃, and has viscosity and plasticity. Fragrant smell, slightly bitter and astringent taste, slightly numb and spicy feeling; propolis has good antiinflammatory effect and antimicrobial activity, and toothpaste containing propolis has good inhibiting effect on dental plaque and preventing and treating dental caries. The toothpaste containing propolis is effective in inhibiting Streptococcus mutans and preventing dental caries.

wherein eucalyptus oil is colorless to yellowish liquid, and has camphor-like and borneol-like odor. The main component of eucalyptus oil refining is cineole, the content of the cineole is 70% -90%, and the cineole contains a small amount of aldehyde, terpene and the like, so that the cineole oil refining agent has good antibacterial and bactericidal properties.

The aquilaria sinensis extract has stronger inhibitory activity on escherichia coli (E.coli), staphylococcus aureus (S.aureus) and rhodotorula (R.glutalis); has obvious inhibiting effect on human non-small cell lung cancer (NCI-H460) cell nucleus in vitro, the inhibiting effect is in positive correlation with the concentration, and when the mass concentration reaches 0.1 g/L, the inhibiting rate reaches 92.56%.

The flos Lonicerae extract has effects of clearing heat and detoxicating, and can improve halitosis and stomatitis caused by excessive internal heat.

The herba Dendrobii extract has effects of nourishing yin, clearing heat, promoting fluid production, and quenching thirst. Can be used for treating febrile disease, impairment of body fluid, thirst, dryness of tongue, asthenia heat after illness, gastropathy, retching, and glossless tongue fur.

The licorice extract has the functions of invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs.

The radix Isatidis extract has effects of clearing heat and detoxicating, cooling blood, and relieving sore throat.

The forsythia suspense extract has the effects of clearing heat, detoxifying, eliminating stagnation, reducing swelling and the like.

The bletilla striata extract has the effects of disinfecting, stopping bleeding, preventing wound infection and the like, and can effectively improve the symptoms of gingival bleeding by adding the bletilla striata extract into toothpaste.

The ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 1-10:1-8:1-7: 1-5.

The ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 4-8:3-6:2-5: 3-5.

The oral bacteriostatic toothpaste also comprises an abrasive, a humectant, a foaming agent and a flavoring agent.

The weight percentage of the abrasive is 15-60%, the weight percentage of the humectant is 20-70%, the weight percentage of the foaming agent is 0.5-3%, and the weight percentage of the flavoring agent is 0.1-2%.

The components of the abrasive are one or the combination of hydrated silica and calcium hydrophosphate.

The humectant comprises one or a combination of sorbitol, propylene glycol and glycerol.

The foaming agent is sodium lauryl sulfate.

Sodium lauryl sulfate is an organic substance with the chemical formula of C12H25SO4Na, and is white or yellowish powder, soluble in water, and insensitive to alkali and hard water. Has the advantages of decontamination, emulsification and excellent foaming power, is an anionic surfactant which is slightly toxic to human bodies, and has the biodegradation degree of more than 90 percent.

The flavoring agent comprises one or more of menthol, essence and xylitol.

Menthol, a terpenoid organic compound, has the chemical formula of C10H 20O. Menthol is extracted from the leaves and stems of peppermint, and is white crystal, which is the main component of peppermint and peppermint essential oils. Menthol generally has two isomers (D-and L-forms), natural menthol being the major levorotatory isomer (L-menthol), and menthol herein is generally referred to as racemic menthol (DL-menthol). Menthol is used as an aromatizer for toothpastes, perfumes, beverages, candies, and the like.

Xylitol is an organic compound with chemical formula of C5H12O5, is native to Finland, and is a natural sweetener extracted from plant materials such as birch, oak, corn cob, and bagasse.

The preparation method of the oral bacteriostatic toothpaste comprises the following steps:

Example 1:

in the embodiment, the oral bacteriostatic toothpaste comprises the following components in percentage by mass:

the bacteriostatic composition comprises the following components: 4%, abrasive: 30% of a humectant: 58% of a foaming agent: 1.5%, flavoring agent: 1.5 percent, and the balance being purified water;

wherein the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis in the antibacterial composition is 7:6:4: 4;

in the plant extracts, the proportion of eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract is 12:10:15:8:13:9:6: 5;

the friction agent comprises hydrated silica;

the humectant is a mixture of sorbitol and glycerol;

the foaming agent is sodium lauryl sulfate;

the flavoring agent comprises menthol, essence and xylitol.

The preparation method comprises the following steps:

Example 2:

the bacteriostatic composition comprises the following components: 4.5%, abrasive: 28% of a humectant: 63% and a foaming agent: 1.8%, flavoring agent: 1.5 percent, and the balance being purified water;

wherein the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis in the antibacterial composition is 8:6:4: 5;

in the plant extracts, the proportion of eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract is 15:11:9:12:17:10:6: 7;

the friction agent comprises hydrated silica;

the humectant is a mixture of sorbitol and glycerol;

the foaming agent is sodium lauryl sulfate;

the flavoring agent comprises menthol, essence and xylitol.

The preparation method comprises the following steps:

Example 3:

the bacteriostatic composition comprises the following components: 3.8%, abrasive: 19% of a humectant: 63% and a foaming agent: 1.6%, flavoring agent: 1.5 percent, and the balance being purified water;

wherein the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis in the antibacterial composition is 10:6:7: 3;

in the plant extracts, the proportion of eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract is 14:12:13:19:8:10:6: 7;

the friction agent comprises hydrated silica;

the humectant is a mixture of sorbitol and glycerol;

the foaming agent is sodium lauryl sulfate;

the flavoring agent comprises menthol, essence and xylitol.

The preparation method comprises the following steps:

Example 4:

the bacteriostatic composition comprises the following components: 4.2%, abrasive: 23% of a humectant: 55% of foaming agent: 1.4%, flavoring agent: 1.7 percent, and the balance of purified water;

wherein the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis in the antibacterial composition is 8:8:6: 5;

in the plant extracts, the proportion of eucalyptus oil, a pistacia chinensis bunge extract, a honeysuckle extract, a dendrobium officinale extract, a liquorice extract, an isatis root extract, a forsythia suspensa extract and a bletilla striata extract is 14:8:16:12:17:8:6: 7;

the friction agent comprises hydrated silica;

the humectant is a mixture of sorbitol and glycerol;

the foaming agent is sodium lauryl sulfate;

the flavoring agent comprises menthol, essence and xylitol.

The preparation method comprises the following steps:

Comparative example 1:

this comparative example differs from example 1 in that: the lactoferrin was replaced by an equal amount of purified water in the formulation.

Comparative example 2:

this comparative example differs from example 1 in that: the lysozyme was replaced by an equal amount of purified water in the formulation.

Comparative example 3:

this comparative example differs from example 1 in that: the eucalyptus oil in the plant extract is replaced by an equal amount of purified water.

Comparative example 4:

this comparative example differs from example 1 in that: the formula uses the same amount of purified water to replace the extract of the balsamiferous wood in the plant extract.

And (3) testing the antibacterial performance:

the oral cavity antibacterial toothpaste prepared in the examples 1-4 and the comparative examples 1-4 are respectively taken to prepare corresponding solutions of 50 mug/mL, and the antibacterial activity of the oral cavity antibacterial toothpaste on escherichia coli, staphylococcus aureus and streptococcus mutans is tested by a bacteriostatic ring method, and the test results are shown in the table 1:

TABLE 1

As can be seen from the data in the table, the oral bacteriostatic toothpaste provided in examples 1 to 4 of the present invention has a good inhibitory effect on common harmful bacteria in the oral cavity, such as escherichia coli, staphylococcus aureus, streptococcus mutans, etc., while the comparative examples 1 to 4 also have a certain effect, but the inhibitory effect is obvious in the first examples 1 to 4, so that lactoferrin, lysozyme, eucalyptus oil, and pistacia stratiotes extract can all play an effective bacteriostatic effect in the bacteriostatic toothpaste.

And (3) testing the curative effect of the halitosis:

selecting 400 volunteers all suffering from halitosis caused by stomatitis, wherein the maximum age is 65 years old, the minimum age is 18 years old, the proportion of men and women is moderate, the patients are randomly and averagely divided into 8 groups, the groups correspond to the oral cavity antibacterial toothpaste prepared in the examples 1-4 and the comparative examples 1-4 respectively, the volunteers use the corresponding oral cavity antibacterial toothpaste to clean the oral cavity once every morning and evening, the oral cavity is kept for 7 days, and no other oral cavity care products are used in the period;

and (3) counting the treatment effect after 7 days, wherein the judgment standard of the treatment effect is as follows:

the method has the following advantages: reduction or partial disappearance of symptoms of discomfort;

and (3) curing: the discomfort symptom disappears, and no recurrence occurs;

and (4) invalidation: the discomfort symptoms are unchanged or recur.

The test results are shown in table 2:

TABLE 2

As can be seen from the data in table 2, the oral cavity antibacterial toothpaste provided in examples 1 to 4 of the present invention has significant efficacy in the improvement and treatment of halitosis, and has a high overall effective rate, and the cure rate is above 80%, while the oral cavity antibacterial toothpaste provided in comparative examples 1 to 4 has a better efficacy, but the efficacy is significantly poorer than that of examples 1 to 4, so that the antibacterial action of lactoferrin, lysozyme, eucalyptus oil and the pistacia weinmannifolia extract has a good effect in suppressing and eliminating halitosis.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the invention can be made, and equivalents and modifications of some features of the invention can be made without departing from the spirit and scope of the invention.

Claims

1. An oral bacteriostatic toothpaste with anti-inflammation and halitosis-removing functions is characterized by comprising a bacteriostatic composition, wherein the mass percentage of the bacteriostatic composition in the oral bacteriostatic toothpaste is 1-5%;

2. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 1, wherein: the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 1-10:1-8:1-7: 1-5.

3. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 2, wherein: the ratio of the plant extract, the lysozyme, the lactoferrin and the propolis is 4-8:3-6:2-5: 3-5.

4. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 1, wherein: the oral bacteriostatic toothpaste also comprises an abrasive, a humectant, a foaming agent and a flavoring agent.

5. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 4, wherein: the weight percentage of the abrasive is 15-60%, the weight percentage of the humectant is 20-70%, the weight percentage of the foaming agent is 0.5-3%, and the weight percentage of the flavoring agent is 0.1-2%.

6. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 4, wherein: the components of the abrasive are one or the combination of hydrated silica and calcium hydrophosphate.

7. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 4, wherein: the humectant comprises one or a combination of sorbitol, propylene glycol and glycerol.

8. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 4, wherein: the foaming agent is sodium lauryl sulfate.

9. The oral bacteriostatic toothpaste with the functions of diminishing inflammation and removing halitosis according to claim 4, wherein: the flavoring agent comprises one or more of menthol, essence and xylitol.

10. The antibacterial toothpaste for oral cavity with anti-inflammatory and halitosis removing functions of any one of claims 1-9, wherein: the preparation method of the oral bacteriostatic toothpaste comprises the following steps: