CN117064833A - Antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts and preparation method thereof - Google Patents
Antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts and preparation method thereof Download PDFInfo
- Publication number
- CN117064833A CN117064833A CN202311291697.8A CN202311291697A CN117064833A CN 117064833 A CN117064833 A CN 117064833A CN 202311291697 A CN202311291697 A CN 202311291697A CN 117064833 A CN117064833 A CN 117064833A
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- China
- Prior art keywords
- parts
- antibacterial
- natural plant
- pure natural
- toothpaste containing
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts and a preparation method thereof, belonging to the technical field of toothpaste. The antibacterial and anti-inflammatory toothpaste provided by the invention comprises the following raw materials: dendrobium officinale, centella asiatica, salvia miltiorrhiza, humifuse euphorbia herb, fibraurea stem, prinsepia utilis royle, agilawood, clove, honeysuckle flower, carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, a humectant, a friction agent, a surfactant, a flavoring agent, a thickening agent, a preservative and water. The antibacterial and anti-inflammatory toothpaste provided by the invention utilizes a gel network formed by carboxymethyl chitosan and oxidized sodium alginate, and combines the extremely strong viscosity of the dendrobium candidum extract, so that the plant extract adsorbed in the gel network is firmly adsorbed on teeth, gums and oral inner films, the slow release effect of the toothpaste is improved, and the effects of inhibiting bacteria, diminishing inflammation and promoting healing of fine wounds of the oral cavity are achieved for a long time.
Description
Technical Field
The invention belongs to the technical field of toothpaste, and particularly relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts and a preparation method thereof.
Background
The eating habits of people in the modern society become diversified and complicated, but the cleaning of the oral cavity and teeth is not improved correspondingly, and a large amount of fine food scraps are often remained on the surfaces of the oral cavity and the teeth. The oral cavity is one of the ways for pathogenic bacteria to invade the human body, and the temperature, humidity and food residues of the oral cavity are suitable for the growth and reproduction of bacteria, so that the color and luster of teeth are changed over time, dental caries is formed, and even dental diseases such as periodontitis, gingivitis, gingival bleeding, dental ulcer, gingival swelling and pain and the like can be developed. Dental diseases damage hard tissues of teeth and supporting tissues around teeth, and cause social interaction difficulties and psychological disorders in addition to the effects of mastication, speech, beauty, etc.
In order to improve oral conditions, toothpaste is an indispensable oral cleaning product in daily life, which is generally applied to toothbrushes, and cleans teeth by mechanically rubbing the toothbrushes to clean the surfaces of the teeth. In recent years, along with the increasing living standard of people, more and more people have higher demands on oral care, and on one hand, the oral care has the effects of protecting the attractive teeth, protecting the gums, preventing halitosis and the like; on the other hand, the requirements of diminishing inflammation and protecting teeth are also met. Therefore, various kinds of toothpaste with health care function are emerging in the market, and particularly, chinese herbal medicine toothpaste has a great market share, and the Chinese herbal medicine toothpaste has certain health care functions of inhibiting harmful bacteria in oral cavity, freshening breath, protecting teeth, preventing and treating oral diseases and the like, and has less safety and side effects, has been widely accepted, but has a lot of defects.
Chinese patent CN 104274375A discloses a breath freshener for wound healing; chinese patent CN 104306456A discloses a breath freshener for improving the onset of warm disease; the breath freshener prepared by the two schemes can effectively relieve cough and remove bad breath, but the antibacterial and anti-inflammatory effects are still to be improved. Patent CN 105616324A discloses a mouthwash containing a plant formula and a preparation method thereof, and the mouthwash mainly aims at resisting bacteria to achieve a nursing effect and cannot solve the problems of gingivitis and the like. Chinese patent CN 111249192A discloses a Chinese herbal medicine toothpaste capable of freshening breath and inhibiting bacteria and resisting inflammation, but has few types of harmful bacteria aiming at the oral cavity and limited antibacterial effect. Therefore, development of toothpaste capable of simultaneously inhibiting various oral harmful bacteria, so that the antibacterial effect is comprehensive, and lasting antibacterial and anti-inflammatory effects are needed.
Disclosure of Invention
In order to solve the technical problems, the invention provides antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts and a preparation method thereof.
The invention provides antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by weight: 5-10 parts of dendrobium candidum, 5-10 parts of centella asiatica, 5-10 parts of red sage root, 1-5 parts of humifuse euphorbia herb, 1-5 parts of caulis fibraureae recisae, 1-5 parts of prinsepia utilis, 1-5 parts of agilawood, 1-5 parts of clove, 1-5 parts of honeysuckle flower, 10-15 parts of carboxymethyl chitosan, 5-10 parts of sodium alginate, 5-10 parts of bamboo salt, 0.1-0.2 part of lysozyme, 0.1-0.2 part of tetrasodium pyrophosphate, 30-50 parts of humectant, 15-20 parts of friction agent, 1.5-2.5 parts of surfactant, 1.0-2.0 parts of flavoring agent, 0.2-1.5 parts of thickening agent, 0.2-1 part of preservative and 15-30 parts of water.
In one embodiment of the invention, the humectant is selected from one or more of sorbitol, polyethylene glycol, glycerin and propylene glycol.
In one embodiment of the invention, the friction agent is selected from silica and/or calcium pyrophosphate.
In one embodiment of the invention, the surfactant comprises sodium lauryl sulfate and sodium lauroyl sarcosinate.
In one embodiment of the invention, the flavoring agents include flavors, erythritol, and sodium saccharin; the mass ratio of the essence to the erythritol to the saccharin sodium is 0.5-1:0.5-1:0.1-0.3.
In one embodiment of the present invention, the thickener is selected from one or more of xanthan gum, cellulose gum, carboxymethyl cellulose and hydroxyethyl cellulose.
In one embodiment of the invention, the preservative is selected from one or more of sodium benzoate, potassium sorbate and parahydroxybenzoate.
The second object of the present invention is to provide a method for preparing the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract, which comprises the following steps,
s1, crushing dendrobium candidum, centella asiatica, salvia miltiorrhiza, humifuse euphorbia herb, fibraurea stem, prinsepia utilis royle, agilawood, clove and honeysuckle into 180-200 meshes, mixing, adding normal saline, soaking, boiling, filtering and concentrating to obtain pure natural plant paste;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, a humectant, a friction agent, a surfactant, a flavoring agent, a thickening agent, a preservative and water into the pure natural plant paste in the S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 20-30 min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
In one embodiment of the present invention, in S1, the mass ratio of the physiological saline to the natural plant is 7-10:1.
in one embodiment of the present invention, in S1, the soaking time is 3h to 4h; the boiling time is 1h-2h; the relative density after concentration is 1.05-1.10.
Compared with the prior art, the technical scheme of the invention has the following advantages:
(1) The added clove extract contains eugenol, is a natural antibacterial agent, has strong bactericidal power and is safe and harmless to human body. Eugenol has analgesic, anesthetic, antibacterial, antioxidant, antipyretic, antitumor, and transdermal absorption promoting effects.
(2) The Prinsepia utilis royle extract added in the invention has the effects of clearing heat, removing toxicity, activating blood, removing stasis, tonifying deficiency, diminishing inflammation, relieving swelling, relieving pain, promoting digestion, invigorating stomach and the like.
(3) The bamboo salt added in the invention contains abundant mineral components and microelements necessary for human bodies such as potassium, magnesium, zinc, calcium and the like, and has good curative effect on inflammation. The bamboo salt is alkaline, so that bacteria and the like in the slightly acidic oral cavity can be effectively neutralized, the pH value balance of a human body can be effectively regulated, and the bamboo salt is very beneficial to oral health.
(4) The dendrobium candidum added by the invention has the effects of supplementing qi, promoting the production of body fluid, nourishing yin, removing heat, relieving swelling, promoting granulation, dredging collaterals and relieving pain, and can play a role in obviously preventing and improving symptoms of oral ulcer, gum swelling and pain, bleeding and halitosis. The Dendrobium officinale extract is Dendrobium officinale flavone, dendrobium officinale alkali, dendrobium officinale phenylpropanoid and the like, and the Dendrobium officinale extract and the Dendrobium officinale phenylpropanoid cooperate with each other to ensure that the toothpaste has the functions of bacteriostasis, antipyresis, analgesia, anti-inflammatory, hemostasis and detumescence.
(5) According to the invention, after the honeysuckle flowers are matched with Huang Tengfu, the added Huang Tengwei bitter taste is utilized, so that remarkable synergistic effect is generated, the antibacterial and anti-inflammatory effects are stronger, the bitter taste of the caulis Fibraureae can be eliminated, the taste is better, and the excellent synergistic effect is generated.
(6) The water-soluble substance component salvianic acid contained in the added salviae miltiorrhizae extract can enhance the anti-inflammatory effect of the fibraurea recisa extract and the dendrobium candidum extract in the toothpaste, is beneficial to strengthening the pain sense of the swelling and pain of the gum and has good analgesic effect.
(7) The antibacterial and anti-inflammatory toothpaste disclosed by the invention utilizes a gel network formed by carboxymethyl chitosan and oxidized sodium alginate, and combines the extremely strong viscosity of the dendrobium candidum extract, so that the plant extract adsorbed in the gel network is firmly adsorbed on teeth, gums and oral cavity inner films, the slow release effect of the toothpaste is improved, and the effects of inhibiting bacteria, diminishing inflammation and promoting healing of fine wounds of the oral cavity are achieved for a long time.
Detailed Description
The present invention will be further described with reference to specific examples, which are not intended to be limiting, so that those skilled in the art will better understand the present invention and practice it.
Example 1
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by mass:
8 parts of dendrobium candidum, 8 parts of centella asiatica, 8 parts of red sage root, 3 parts of humifuse euphorbia herb, 3 parts of fibraurea stem, 3 parts of privet fruit, 3 parts of agilawood, 3 parts of clove, 3 parts of honeysuckle flower, 13 parts of carboxymethyl chitosan, 8 parts of sodium alginate, 8 parts of bamboo salt, 0.15 part of lysozyme, 0.15 part of tetrasodium pyrophosphate, 30 parts of sorbitol, 40010 parts of polyethylene glycol, 18 parts of silicon dioxide, 2 parts of sodium lauryl sulfate, 0.6 part of essence, 0.6 part of erythritol, 0.3 part of saccharin sodium, 0.5 part of xanthan gum, 0.5 part of cellulose gum, 0.6 part of sodium benzoate and 25 parts of water.
The method specifically comprises the following steps:
s1, crushing dendrobium candidum, centella asiatica, red sage root, humifuse euphorbia herb, fibraurea stem, privet fruits, agilawood, clove and honeysuckle into 200 meshes, mixing, adding 8 times of physiological saline, soaking for 3.5 hours, boiling for 1.5 hours, sieving with a 200-mesh sieve, and concentrating to obtain pure natural plant paste with the relative density of 1.08;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, sorbitol, polyethylene glycol-400, silicon dioxide, sodium lauryl sulfate, essence, erythritol, saccharin sodium, xanthan gum, cellulose gum, sodium benzoate and water into the pure natural plant paste in the step S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 25min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
Example 2
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by mass:
10 parts of dendrobium candidum, 10 parts of centella asiatica, 10 parts of red sage root, 5 parts of humifuse euphorbia herb, 5 parts of fibraurea stem, 1 part of privet fruit, 1 part of agilawood, 1 part of clove, 1 part of honeysuckle flower, 15 parts of carboxymethyl chitosan, 5 parts of sodium alginate, 10 parts of bamboo salt, 0.1 part of lysozyme, 0.2 part of tetrasodium pyrophosphate, 20 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts, 20 parts of silicon dioxide, 1.5 parts of sodium lauroyl sarcosinate, 0.9 part of essence, 0.9 part of erythritol, 0.2 part of saccharin sodium, 0.1 part of xanthan gum, 0.1 part of cellulose gum, 1 part of sodium benzoate and 30 parts of water.
The method specifically comprises the following steps:
s1, crushing dendrobium candidum, centella asiatica, salvia miltiorrhiza, humifuse euphorbia herb, fibraurea stem, privet fruits, agilawood, clove and honeysuckle into 200 meshes, mixing, adding 10 times of physiological saline, soaking for 4 hours, boiling for 2 hours, sieving with a 200-mesh sieve, and concentrating until the relative density is 1.10, thus obtaining the pure natural plant paste;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, sorbitol, polyethylene glycol-400, silicon dioxide, sodium lauroyl sarcosinate, essence, erythritol, saccharin sodium, xanthan gum, cellulose gum, sodium benzoate and water into the pure natural plant paste in the step S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 30min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
Example 3
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by mass:
5 parts of dendrobium candidum, 5 parts of centella asiatica, 5 parts of red sage root, 1 part of humifuse euphorbia herb, 1 part of fibraurea stem, 5 parts of privet fruit, 5 parts of agilawood, 5 parts of clove, 5 parts of honeysuckle flower, 10 parts of carboxymethyl chitosan, 5 parts of sodium alginate, 5 parts of bamboo salt, 0.2 part of lysozyme, 0.1 part of tetrasodium pyrophosphate, 40 parts of sorbitol, 40 parts of polyethylene glycol-40010 parts of silicon dioxide, 15 parts of sodium lauroyl sarcosinate, 0.9 part of essence, 0.9 part of erythritol, 0.2 part of saccharin sodium, 1 part of xanthan gum, 0.5 part of cellulose gum, 0.2 part of sodium benzoate and 30 parts of water.
The method specifically comprises the following steps:
s1, crushing dendrobium candidum, centella asiatica, salvia miltiorrhiza, humifuse euphorbia herb, fibraurea stem, privet fruits, agilawood, clove and honeysuckle into 180 meshes, mixing, adding 7 times of physiological saline, soaking for 3 hours, boiling for 1 hour, sieving with a 200-mesh sieve, and concentrating to obtain pure natural plant paste with the relative density of 1.05;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, sorbitol, polyethylene glycol-400, silicon dioxide, sodium lauroyl sarcosinate, essence, erythritol, saccharin sodium, xanthan gum, cellulose gum, sodium benzoate and water into the pure natural plant paste in the step S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 20min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
Example 4
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by mass:
10 parts of dendrobium candidum, 10 parts of centella asiatica, 10 parts of red sage root, 5 parts of humifuse euphorbia herb, 5 parts of fibraurea stem, 5 parts of privet fruit, 5 parts of agilawood, 5 parts of clove, 5 parts of honeysuckle flower, 15 parts of carboxymethyl chitosan, 10 parts of sodium alginate, 10 parts of bamboo salt, 0.2 part of lysozyme, 0.1 part of tetrasodium pyrophosphate, 20 parts of sorbitol, 10 parts of polyethylene glycol-40010 parts of silicon dioxide, 15 parts of sodium lauryl sulfate, 1.5 parts of essence, 0.9 part of erythritol, 0.2 part of saccharin sodium, 0.1 part of xanthan gum, 0.1 part of cellulose gum, 0.2 part of sodium benzoate and 15 parts of water.
The method specifically comprises the following steps:
s1, crushing dendrobium candidum, centella asiatica, red sage root, humifuse euphorbia herb, fibraurea stem, privet fruits, agilawood, clove and honeysuckle into 200 meshes, mixing, adding 8 times of physiological saline, soaking for 3.5 hours, boiling for 1.5 hours, sieving with a 200-mesh sieve, and concentrating to obtain pure natural plant paste with the relative density of 1.08;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, sorbitol, polyethylene glycol-400, silicon dioxide, sodium lauryl sulfate, essence, erythritol, saccharin sodium, xanthan gum, cellulose gum, sodium benzoate and water into the pure natural plant paste in the step S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 25min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
Example 5
The invention relates to antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts, which comprises the following raw materials in parts by mass:
5 parts of dendrobium candidum, 5 parts of centella asiatica, 5 parts of red-rooted salvia root, 1 part of humifuse euphorbia herb, 1 part of fibraurea stem, 1 part of privet fruit, 1 part of agilawood, 1 part of clove, 1 part of honeysuckle flower, 10 parts of carboxymethyl chitosan, 5 parts of sodium alginate, 5 parts of bamboo salt, 0.1 part of lysozyme, 0.2 part of tetrasodium pyrophosphate, 40 parts of sorbitol, 40 parts of polyethylene glycol-40010 parts of silicon dioxide, 20 parts of sodium lauryl sulfate, 2.5 parts of essence, 0.9 part of erythritol, 0.2 part of saccharin sodium, 1 part of xanthan gum, 0.5 part of cellulose gum, 1 part of sodium benzoate and 30 parts of water.
The method specifically comprises the following steps:
s1, crushing dendrobium candidum, centella asiatica, red sage root, humifuse euphorbia herb, fibraurea stem, privet fruits, agilawood, clove and honeysuckle into 200 meshes, mixing, adding 8 times of physiological saline, soaking for 3.5 hours, boiling for 1.5 hours, sieving with a 200-mesh sieve, and concentrating to obtain pure natural plant paste with the relative density of 1.08;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, sorbitol, polyethylene glycol-400, silicon dioxide, sodium lauryl sulfate, essence, erythritol, saccharin sodium, xanthan gum, cellulose gum, sodium benzoate and water into the pure natural plant paste in the step S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 25min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
Comparative example 1
Basically the same as in example 1, except that Dendrobium officinale was not added.
Comparative example 2
Substantially the same as in example 1, except that no root of red-rooted salvia was added.
Comparative example 3
Substantially the same as in example 1, except that fibraurea stem was not added.
Comparative example 4
Substantially the same as in example 1, except that prinsepia utilis royle was not added.
Comparative example 5
Substantially the same as in example 1, except that carboxymethyl chitosan was not added.
Comparative example 6
Substantially the same as in example 1, except that lysozyme was not added.
Test example 1
120 Balb/C mice (60 male and female mice) were selected and divided into 5 test groups (corresponding to examples 1-5) and 1 control group, and 10 male and female mice were fed with the extract obtained in examples 1-5 (concentration of 0.8g/10 mL), and fasted for 8 hours before and 4 hours after administration, but not water. Each mouse was perfused with 0.3mL/10g of the suspension at a weight of each mouse once a day, each time in the morning, in the evening, and at 4h intervals, three times total, and observed continuously for 7 days. Observing the growth state and active diet of the white mice, and identifying hematology, hematochemistry, organ tissue structure, urine routine and the like. The result shows that all mice survive healthily without any toxic or side effect; the heart, liver, spleen, kidney, lung and intestine tissue states were observed anatomically, and were indistinguishable from the control mice. The dose of mice in the test is 94 times of the clinical daily dose of adults, and the single dose of adults is 315 times, which means that the product is safe for adults.
Test example 2
With reference to the antibacterial performance test method of the disposable hygienic product hygienic standard GB 15979-2002C4 dissolution antibacterial products, the antibacterial and anti-inflammatory toothpastes prepared in examples 1-5 and comparative examples 1-6 are used as test objects, and the inhibition rates (%) of the toothpastes on staphylococcus aureus, escherichia coli, candida albicans, streptococcus sanguinis, streptococcus mutans and actinomycetes viscosus are measured, and the results are shown in Table 1:
TABLE 1
As can be seen from table 1, the toothpaste of the invention has excellent antibacterial and antiseptic effects, and the combination of dendrobium candidum, red sage root, fibraurea stem, prinsepia utilis royle, carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme and the like synergistically has an effect on antibacterial and antiseptic, and the addition of lysozyme and carboxymethyl chitosan is beneficial to better improving oral environment.
Test example 3
110 Balb/C mice (male and female halves) are selected, the mice are randomly divided into 11 groups, 10 mice in each group are anesthetized by diethyl ether, 20 mu L of dimethylbenzene is uniformly smeared on the right ear of the mice, after 30min, 0.5mL of toothpaste prepared in examples 1-5 and comparative examples 1-6 is smeared on the right ear inflammation part of the mice for 10min for 6 times continuously, the left ear is not treated, after 4h, the mice are killed, the ears are cut off immediately, the ears on the same part are picked by an 8mm puncher, and the swelling degree and swelling rate are calculated by weighing; swelling degree = right ear weight-left ear weight, swelling rate = swelling degree/left ear weight, average, results are shown in table 2:
TABLE 2
As can be seen from Table 2, the anti-inflammatory effects of the present invention in examples 1 to 5 were significantly different from those in comparative examples 1 to 6, indicating that the antibacterial and anti-inflammatory toothpaste of the present invention had good anti-inflammatory effects.
Test example 4
About 22g of female Balb/C mice are placed on a hot plate pain tester, 200 qualified mice are screened (the foot time after licking is less than 5s or more than 30s for discarding, the cut-off time is set for preventing foot scalding, and the cut-off time is generally 60 s), 110 female mice are taken as pain threshold indexes by taking the incubation period of the foot reaction of the mice, and the mice are divided into 11 groups, namely, the groups of examples 1-5 and comparative examples 1-6. The toothpastes prepared in examples 1 to 5 and comparative examples 1 to 6 were applied to the foot scalding portion of mice once a day for 6 times a day for 2 consecutive days, and the time for the foot addition to occur within 60 minutes and 120 minutes after the last dose was measured, and the results are shown in Table 3:
TABLE 3 Table 3
As can be seen from Table 3, after the mice are coated with the toothpastes for 1h and 2h, the time for adding the toothpastes prepared in the embodiments 1-5 of the present invention to the mice is obviously shorter than that of the toothpastes prepared in the comparative examples 1-6, which indicates that the toothpaste of the present invention can reduce the time for adding the toothpastes to the mice, and further indicates that the compatibility of the active ingredients in the ingredients of the present invention has good analgesic effect.
It is apparent that the above examples are given by way of illustration only and are not limiting of the embodiments. Other variations and modifications of the present invention will be apparent to those of ordinary skill in the art in light of the foregoing description. It is not necessary here nor is it exhaustive of all embodiments. And obvious variations or modifications thereof are contemplated as falling within the scope of the present invention.
Claims (10)
1. An antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts is characterized by comprising the following raw materials in parts by weight: 5-10 parts of dendrobium candidum, 5-10 parts of centella asiatica, 5-10 parts of red sage root, 1-5 parts of humifuse euphorbia herb, 1-5 parts of caulis fibraureae recisae, 1-5 parts of prinsepia utilis, 1-5 parts of agilawood, 1-5 parts of clove, 1-5 parts of honeysuckle flower, 10-15 parts of carboxymethyl chitosan, 5-10 parts of sodium alginate, 5-10 parts of bamboo salt, 0.1-0.2 part of lysozyme, 0.1-0.2 part of tetrasodium pyrophosphate, 30-50 parts of humectant, 15-20 parts of friction agent, 1.5-2.5 parts of surfactant, 1.0-2.0 parts of flavoring agent, 0.2-1.5 parts of thickening agent, 0.2-1 part of preservative and 15-30 parts of water.
2. The antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 1, wherein the humectant is selected from one or more of sorbitol, polyethylene glycol, glycerin and propylene glycol.
3. Antibacterial and anti-inflammatory toothpaste containing purely natural plant extracts according to claim 1, characterized in that the abrasive is selected from silica and/or calcium pyrophosphate.
4. The antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 1, wherein the surfactant comprises sodium lauryl sulfate and sodium lauroyl sarcosinate.
5. The antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 1, wherein the flavoring agent comprises essence, erythritol and saccharin sodium; the mass ratio of the essence to the erythritol to the saccharin sodium is 0.5-1:0.5-1:0.1-0.3.
6. The antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 1, wherein the thickener is selected from one or more of xanthan gum, cellulose gum, carboxymethyl cellulose and hydroxyethyl cellulose.
7. The antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 1, wherein the preservative is selected from one or more of sodium benzoate, potassium sorbate and parahydroxybenzoate.
8. The method for preparing antibacterial and anti-inflammatory toothpaste containing pure natural plant extract according to any one of claims 1 to 7, characterized by comprising the following steps,
s1, crushing dendrobium candidum, centella asiatica, salvia miltiorrhiza, humifuse euphorbia herb, fibraurea stem, prinsepia utilis royle, agilawood, clove and honeysuckle into 180-200 meshes, mixing, adding normal saline, soaking, boiling, filtering and concentrating to obtain pure natural plant paste;
s2, adding carboxymethyl chitosan, sodium alginate, bamboo salt, lysozyme, tetrasodium pyrophosphate, a humectant, a friction agent, a surfactant, a flavoring agent, a thickening agent, a preservative and water into the pure natural plant paste in the S1, stirring to prepare an aqueous solution, sucking the aqueous solution into a paste preparation machine, stirring and grinding for 20-30 min until the paste is uniform, and synchronously carrying out vacuum defoaming to obtain the antibacterial and anti-inflammatory toothpaste containing the pure natural plant extract.
9. The method for preparing antibacterial and anti-inflammatory toothpaste containing pure natural plant extracts according to claim 8, wherein in S1, the mass ratio of the physiological saline to the natural plant is 7-10:1.
10. the method for preparing antibacterial and anti-inflammatory toothpaste containing pure natural plant extract according to claim 8, wherein in S1, the soaking time is 3-4 h; the boiling time is 1h-2h; the relative density after concentration is 1.05-1.10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150022574A (en) * | 2013-08-23 | 2015-03-04 | (주)제노랩 | Oral liquid-type composition comprising natural polyelectrolytes and method for their preparation |
| CN113546029A (en) * | 2021-07-14 | 2021-10-26 | 北京圣永制药有限公司 | Oral antibacterial toothpaste with functions of diminishing inflammation and removing halitosis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150022574A (en) * | 2013-08-23 | 2015-03-04 | (주)제노랩 | Oral liquid-type composition comprising natural polyelectrolytes and method for their preparation |
| CN113546029A (en) * | 2021-07-14 | 2021-10-26 | 北京圣永制药有限公司 | Oral antibacterial toothpaste with functions of diminishing inflammation and removing halitosis |
Non-Patent Citations (4)
| Title |
|---|
| 中国医学科学院药用植物资源开发研究所: "《中药志》", 31 January 1994, 人民卫生出版社, pages: 732 * |
| 国家食品药监督管理总局: "化妆品准用防腐剂", 《化妆品安全技术规范》, 1 December 2016 (2016-12-01), pages 113 * |
| 季正俊等: "《特色保健植物青刺果规范化栽培及综合开发利用》", 30 June 2022, 云南科技出版社, pages: 31 - 32 * |
| 梁晓宇: "羧甲基壳聚糖的研究及在牙膏中的应用", 《牙膏工业》, vol. 19, no. 1, 31 January 2009 (2009-01-31), pages 35 - 37 * |
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