WO2015034252A1

WO2015034252A1 - Toothpaste containing medicinal herb extract and propolis

Info

Publication number: WO2015034252A1
Application number: PCT/KR2014/008247
Authority: WO
Inventors: 어수옥; 심재경
Original assignee: 주식회사 경방
Priority date: 2013-09-09
Filing date: 2014-09-03
Publication date: 2015-03-12
Also published as: KR101391545B1

Abstract

The present invention relates to a traditional Korean medicinal toothpaste containing a medicinal herb extract and propolis, wherein a medicinal herb extract extracted from Cnidium officinale Makino, Angelica gigas Nakai, Angelica dahurica Benth, Mentha arvensis L., Artemisia capillaris Thunberg, Glycyrrhiza uralensis Fischer and pine needles is added to a toothpaste for tooth whitening, plaque removal and periodontal disease inhibition, thereby minimizing the irritation of a toothpaste, improving the efficacy and feeling of use of medicinal herbs, and enhancing sterilization for the antibacterial effect and inflammation prevention inside the mouth so as to hygienically maintain the teeth and the mouth and prevent and treat cavities and periodontitis. According to the present invention, provided is a traditional Korean medicinal toothpaste containing a medicinal herb extract and propolis, wherein a medicinal herb extract comprising Cnidium officinale Makino, Angelica gigas Nakai, Angelica dahurica Benth, Mentha arvensis L., Artemisia capillaris Thunberg, Glycyrrhiza uralensis Fischer and pine needles and propolis are added to a toothpaste comprising: precipitated calcium carbonate and calcium hydrogen phosphate as an abrasive for polishing the outer surface of the teeth; aminocaproic acid and aluminum chlorohydroxy allantoinate, which are agents for preventing periodontal diseases and inflammation; sorbitol, glycerin and xylitol, which are wetting agents for preventing solidification; polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and xanthan gum, which are binders for binding a powder and a liquid ingredient; sodium lauryl sulfate which is a foaming agent for allowing medicinal ingredients to be dispersed and penetrated rapidly; sodium benzoate, a green tea extract, sodium saccharin, menthol, peppermint oil and blue No. 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; and purified water.

Description

Toothpaste with Herbal Extract and Propolis

The present invention is added to the traditional toothpaste for tooth whitening and plaque removal and suppression of periodontal disease by adding herbal extracts and propolis extracted from Cheongung, Angelica, white paper, peppermint, cedar, licorice, pine needles, as well as minimizing the stimulation of toothpaste Toothpaste with herbal extracts and propolis, which improves the feeling of use and improves disinfection of antibacterial and inflammation in the oral cavity, keeps teeth and oral clean, and prevents and treats tooth decay and periodontitis. It is about.

Before toothpaste, teeth were rubbed with the stems and leaves of plants, but the removal and cleaning effect of plaque was insufficient.

Therefore, in order to improve this, powdered tooth powder (가루: powdered toothpaste) has emerged.

However, in the case of the tooth powder, the abrasive for the cleaning effect is the main component, the removal of plaque and rehabilitation are increased, but the polishing force is so high that when used in addition to toothpaste, side effects such as abrasion of the teeth are generated, and the current semi-solid to improve the Toothpaste has emerged.

Since the current toothpaste contains a humectant to maintain a semi-solid form together with the abrasive, the polishing degree can be adjusted to a desired level by controlling the content of the abrasive.

In addition to the basic functions of plaque removal and tooth cleaning, modern toothpaste contributes to improving oral hygiene by using various medicinal agents and herbal medicines for the treatment and prevention of various oral diseases such as tooth decay, gingivitis, bad breath, and whitening.

In particular, the extracts of plants whose efficacy has been confirmed in both East and West are applied to toothpaste in the form of essential oils and powders, which are used for the treatment and prevention of oral diseases. In addition, through the strong antibacterial action of propolis honey extract can suppress oral diseases.

Known major functional toothpaste techniques are as follows. Publication No. 1996-0003712 relates to a toothpaste composition containing propolis, which discloses a toothpaste composition comprising 0.01 to 5.0% by weight, preferably 0.1 to 1.0% of propolis, and Publication No. 1997-0009782. The present invention relates to a toothpaste composition containing propolis, which contains 5 to 15% by weight of alcoholic and water-soluble extracts of propolis in general toothpaste composition, and Publication No. 1998-0008209 relates to a toothpaste composition. A toothpaste composition containing 1.0% by weight and 0.01-5.0% by weight of green tea extract is described. Publication No. 2000-0012139 relates to a propolis extract, which is carried out in gas chromatography using p-ethyl phenol as an internal standard. Content of odor component with relative residence time of p-ethyl phenol of 0.7 to 0.8 and / or the same as above. This is a technique for extracting propolis with reduced content of other odor components with relative residence time of 1.2 to 1.3. Publication No. 2006-0108917 relates to gum love herbal toothpaste, which shows prevention and treatment of periodontal disease. Toothpaste composition for preventing and treating periodontal disease, which contains licorice extract, allantoin, propolis, chitosan, and xyitol in a ratio of 1: 5 to 1: 6 by weight in aminocaproic acid and apatite chemotherapeutic agent components, which are common toothpaste compositions A toothpaste composition is disclosed, and Publication No. 2010-0117328 relates to a toothpaste containing a natural spearmint powder and a method for preparing the toothpaste. The mixture of natural spearmint powder and propolis in a common toothpaste composition is 0.5- by weight. Toothpaste containing 5% natural spearmint powder is described. Publication No. 2011-01374 No. 51 relates to a functional toothpaste composition, wherein when 100 ml of toothpaste is used as the total weight, 15 g of briquettes powder, 30 g of bamboo salt, as an abrasive using natural fiber as a neutral tank (sodium bicarbonate) or a natural adsorption abrasive in the abrasive, 12g of sterile vinegar, 3g kaolin clay, 30g glycerin, 3g pine resin, 5g mulberry extract, 2g allantoin or propolis, 5 drops grapefruit seed extract, 2 drops lemon and 4 drops peppermint A functional toothpaste composition is characterized by adjusting the total weight through the generation of moisture during the mixing process, and Publication No. 2012-0053370 relates to a syrup preventive toothpaste composition containing a lead extract and a method for preparing the same Calcium 5-15 wt%, Glycerin 1-2 wt%, D-Solbitol solution 18.9-70.65 wt%, Polyethylene glycol 1-5 wt%, Silicon dioxide 7.0-15.0 wt%, Xylitol 0.01-1.0 wt%, Propolis 0.01-0.6 wt%, Stevioside 0.01-2.0 wt%, grapefruit seed extract 0.01-2.0 wt%, safflower seed oil 0.1-1.0 wt%, annual extract 5-9.5 wt%, willow extract A rot preventive toothpaste composition using a lead extract composed of 0.1 to 5.0% by weight, 0.10 to 3.0% by weight of cocaidopropyl betaine, 0.01 to 2.0% by weight of DL-menthol and 10 to 18% by weight of purified water is described.

Summary of the Invention

Conventional toothpaste contains an extract extracted from the leaves of Camellia family for the treatment of periodontal disease and various oral diseases, or extracts of various plant leaves or petals are used, but in this case, the effects of treatment and prevention of various oral diseases However, when the toothpaste is used for a long time, the color of the toothpaste is changed or the fragrance is changed, so the effectiveness of the medicament contained in the toothpaste is reduced, and there is a problem in that the toothpaste is inferior in marketability.

In addition, tea tree oil extracted from tea tree is used as a flavoring agent to remove plaque or gingivitis, but in this case, the amount of tea tree oil is limited to the appropriate level of flavor to be added to toothpaste. There was also a problem that was not easy to use.

Therefore, the present invention is to suppress the deformation of the toothpaste as much as possible to solve the problems of the conventional toothpaste as described above, and to provide a toothpaste with a herbal extract and propolis added with less stimulation and improved efficacy and usability. have.

The present invention has been invented to solve the above problems, precipitated calcium carbonate and calcium hydrogen phosphate which is an abrasive for cleaning the tooth surface; Aminocaproic acid and allantoinchlorohydroxyaluminum, which are agents for preventing periodontal disease and preventing inflammation; Sorbitol, glycerin and xylitol, as humectants to prevent coagulation; Polyethylene glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum, which are binders for combining powder and liquid components; Sodium lauryl sulfate, which is a foaming agent for prompting dispersion and penetration of the active ingredient; Sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil and food coloring blue 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; Toothpaste prepared with purified water provides perforated, Angelica, white paper, peppermint, cedar, licorice, herbal extracts including pine needles, and herbal extracts and propolis added to the propolis is added.

Detailed Description of the Invention and Specific Embodiments

The present invention relates to a toothpaste for whitening teeth, removing plaque and suppressing periodontal disease. Amino acid, a pharmaceutical agent for preventing precipitated calcium carbonate and calcium hydrogen phosphate, and periodontal disease, which is an abrasive for cleaning the surface of teeth. Caproic acid, allantoinchlorohydroxyaluminum, sorbitol, glycerol, xylitol, wetting agent to prevent coagulation, polyethylenglycol (PEG), carboxymethylcellulose (CMC), xanthan gum, Sodium lauryl sulfate, a foaming agent for rapid dispersing and penetration of ingredients, and sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil, and food coloring, blue 1, which are additives to suppress the growth of microorganisms and improve the feeling of use. And toothpaste containing perforated, Angelica, white paper, peppermint, mugwort, licorice, pine needles It relates to herbal extracts and propolis added to the herbal extracts and propolis added toothpaste.

The abrasive is a component that acts to clean the dry surface of the tooth and is composed of precipitated calcium carbonate and calcium hydrogen phosphate.

The drug is used to sterilize the bacteria in the oral cavity, inhibit the production of plaque, and remove the generated plaque. It is composed of aminocaproic acid and allantoinchlorohydroxyaluminum.

In addition, the humectant is an essential ingredient to make the semi-solid form of toothpaste. It prevents the toothpaste from drying and solidifying when exposed to the air. It is composed of sorbitol, glycerin and xylitol. .

In addition, the binder used in semi-solid toothpaste is composed of polyethylen glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum because it plays a role of preventing the solid powder component and the liquid component from being separated.

In addition, the foaming agent, which quickly disperses and penetrates the active ingredients and reduces the interfacial tension, easily removes foreign substances in the oral cavity, and is composed of sodium lauryl sulfate, an anionic surfactant, and an additive for improving the feel of toothpaste. Sodium benzoate, green tea extract, sodium saccharin, menthol and peppermint oil.

It is a feature of the present invention that herbal extracts including perforated, Angelica, white paper, peppermint, evergreen mugwort, licorice, pine needles, and propolis are added to the toothpaste containing purified water in the above components. Efficacy and ingredients of each herbal medicine as described above are as follows.

Firstly, Cheonggung is a root stem of perennial herbaceous perennial herb and cheoncheongung belonging to the Araaceae family. It is a representative medicine of live blood medicinal herbs. It helps smooth circulation of Qi and blood. Has antibacterial function

Therefore, when used in addition to toothpaste is effective in the prevention of plaque generated on the outer surface of the tooth and the removal of the generated plaque, it also has the effect of relieving toothache.

Secondly, Angelica is a root of perennial herbaceous Angelica belonging to the Apiaceae, which is used as a representative herbal medicine of blood donor, which improves blood flow and improves flow, so it is used for pain caused by anemia or bleeding disorder. It is effective in treating tooth pain caused by or eliminating bad breath.

Thirdly, the white paper is the root of copper leaf, a perennial herb belonging to the Apiaceae, which is a representative herbal medicine of analgesics and is useful for alleviating various pains.

The fourth mint is a perennial herb, a perennial herb that belongs to the Lamiaceae. Its fragrance is very good and strong. When used in addition to toothpaste, it has an excellent effect on the removal of odor from the mouth. It also has antiseptic and antiseptic effect.

Fifth, mugwort is dried dried outpost of chrysanthemums belonging to the chrysanthemum family. It is also used to improve moist heat and to treat jaundice, and when used in toothpaste, it can get excellent antibacterial effect against oral disease-causing bacteria.

Sixth, licorice is the root of licorice, a perennial herb belonging to the legume, and is used as an antidote for all poisoning. It is very useful not only for herbal medicine but also for new medicine and folk medicine.

In addition, when used in addition to toothpaste, two antibacterial substances in licorice, Licorisidine and Licolyoflavan, are responsible for killing the main oral bacteria that cause tooth decay and gum disease. Effective in preventing

Lastly, pine needles are extracted from pine leaves, rich in oxygen and minerals. When used in toothpaste, phytoncide contained in pine needles is antibacterial and terpene inhibits oxidation, causing pain when gums are sore and painful. It is effective in alleviating bad breath and removing bad breath caused by tooth decay and periodontal disease.

Propolis, a natural antibiotic called nature's penicillin, also contains white blood cells to fight off bacteria that enter the body. It is a substance secreted by itself.

Propolis is used as a raw material for antibacterial, antiviral, antiseptic, antifungal, and antibiotics. Since it is not harmful to the human body, it has no side effects or resistance and is effective for treating wounds and ulcers inside and outside the body. It also prevents and improves the skin. Numerous studies and treatments have demonstrated the effectiveness of propolis to enhance immune tissues. In particular, flavonoids, a type of antioxidant contained in propolis, are known as a major component directly related to the body's immune system.

Propolis, which is called natural antibiotic, has various functions such as skin antioxidant effect, anti-inflammatory and whitening.

Herein, the propolis may be referred to as a flavonoid which is the most important substance among the components of the propolis. In 1970, at the former Soviet Academy of Sciences, Dr. UHVillanueva discovered 18 species of flavonoids in propolis, and announced that it contained antibiotics such as Galantina and Piocemorina. It is revealed that this flavonoid ingredient can keep the genus sterile.

Flavonoids are widely distributed in the plant system, and most of them are present as glycosides, but most of the characteristics of flavonoids found in propolis are hydrolyzed and present in the form of aglycons.

This non-sugar sugar flavonoid is absorbed by the human body, which is characterized by the action of inhibiting the reaction of specific enzymes (antioxidant action), strengthening cell membranes, making the skin healthy and beautiful, and strengthening connective tissues ( Cell regeneration), antiallergic action and inhibition of the release of chemicals in mast cells that cause allergies, strengthening the production of phagocytes or antibodies in the body, regulating the immune system of body tissues to enhance antirheumatics, anti-AIDS, etc. It promotes the immune system of the whole body and increases resistance to infection.

The herbal extracts and propolis were prepared using a solution extraction method using a known herbal extraction method, the specific method is as follows.

15-25 weight% of celestial organs, 15-25 weight% of Angelica, 15-25 weight% of white paper, 5-15 weight% of peppermint, 5-15 weight% of cedar wormwood, licorice 2.5-7.5 weight%, pine needles 2.5-7.5 weight%, pro 1000 g of water is mixed with 1000 g of 5-15% by weight of mixed raw materials, and the hot water is extracted by heating at 120-122 ° C. and 15 psi for 3-4 hours.

The content of the herbal extract and propolis in 100% by weight of the herbal extract and propolis to which the present invention is added is preferably 0.2% by weight to 1.0% by weight, and more preferably 0.2% by weight to 0.4% by weight. When the content of herbal extracts and propolis is lower than 0.2% by weight, the efficacy of the toothpaste according to the present invention is insufficient, and when the content exceeds 1.0% by weight, the cost is excessively increased compared to the efficacy of the toothpaste, and it is half the taste or smell. It was felt that the experiment was undesirable.

And the preferred content of each component for 100% by weight of herbal extracts and propolis is 15-25% by weight Cheongung, 15-25% by weight Angelica, 15-25% by weight white paper, 5-15% by weight peppermint 5-15 It is composed of weight%, licorice 2.5-7.5% by weight, pine needles 2.5-7.5% by weight, propolis 5-15% by weight.

Here, Example 1 shows a method of preparing a toothpaste mainly on the content ratio of the general toothpaste composition and the additional herbal medicines added according to the present invention.

Example 1

1. The binder was previously prepared by dispersing the binder in the mixed wetting agent, and the other ingredients (pharmaceuticals, additives, herbal extracts) were dispersed and mixed, and then the abrasive was added and stirred for about 30 minutes.

2. Then, the foaming agent was added and stirred for 20 minutes in a vacuum to obtain a final product.

At this time, the humectant is composed of 30g of sorbitol, 5g of glycerin, 10g of xylitol and the binder is composed of 0.5g of PEG, 1g of CMC, and 0.3g of xanthan gum.

In addition, among other ingredients, the drug consists of 0.1 g of aminocaproic acid, 0.08 g of allantoin chlorohydroxyaluminum, and 0.01 g of sodium benzoate,

The additive consists of 11g of green tea extract, 1g of saccharin sodium, 7g of menthol, 8g of peppermint oil, 1.07g of blue No. 1 (edible pigment),

Purified water consists of 10 g.

And the abrasive is composed of precipitated calcium carbonate 14.55g, calcium hydrogen phosphate 0.08g and the foaming agent is composed of 0.01g sodium lauryl sulfate.

In addition, herbal extracts and propolis are added according to the characteristics of the present invention, the herbal medicines included in the herbal extracts are: 0.06g Cheonung, Angelica 0.06g, white paper 0.06g, peppermint 0.03g, cauliflower 0.03g, licorice 0.015g, pine needles It is composed of 0.015g and 0.030g of propolis, the content of each component for 100% by weight of herbal extract and propolis is 20% by weight, Angelica 20% by weight, 20% by weight of white paper, 10% by weight of peppermint, 10% by weight of cedar %, Licorice 5% by weight, pine needles 5% by weight Propolis 10% by weight.

Adult male and female 20 who have complained or diagnosed symptoms of periodontitis, toothache, bad breath, tooth decay, and the toothpaste (A) and herbal extract and propolis to which the herbal extract and propolis are added described in Examples Ten patients were asked to use (B) toothpaste and 10 others (A) toothpaste twice a day for 15 days, and the results of the survey were evaluated.

Table 1

Survey Results (Unit: Acquisition)

division	No effect	Effective	A significant effect	Cure effect	system
(B) Toothpaste	5	2	2	One	10
(A) Toothpaste	One	One	4	4	10

In order to confirm the deodorizing effect of the herbal extract of the present invention and the toothpaste added with propolis, as a result of requesting deodorization experiment by Korea Institute of Far Infrared Evaluation, it was proved that there was an excellent deodorizing effect of 91% in 2 hours. The test results are as follows.

TABLE 2

Deodorization test result

Test Items	Elapsed time (minutes)	Blank concentration (ppm)	Sample concentration (ppm)	Deodorization rate (%)
Deodorization test	Early	500	500	-
	30	480	80	83
	60	470	60	87
	90	460	50	89
	120	450	40	91

In addition, to confirm the antimicrobial effect of the herbal extracts and propolis-added toothpaste of the present invention, as a result of the antimicrobial test conducted by the Korea Institute of Far Infrared Evaluation, E. coli was sterilized 99.9% in 24 hours, staphylococcus Cocci also proved to have an excellent antimicrobial effect, killing 99.9% in 24 hours.

TABLE 3

Antibacterial Test Results

Test Items	Sample classification	Initial concentration (CFU / ml)	Concentration after 24 hours (CFU / ml)	Bacteriostatic reduction rate (%)
Antibacterial Test by Escherichia Coli	Blank	1.2 × 10 ⁵	1.1 × 10 ⁶	-
Antibacterial Test by Escherichia Coli	Propolis toothpaste	1.2 × 10 ⁵	<1.0 × 10 ³	99.9
Antibacterial Test by Staphylococcus	Blank	1.7 × 10 ⁵	2.3 × 10 ⁶	-
Antibacterial Test by Staphylococcus	Propolis toothpaste	1.7 × 10 ⁵	<1.0 × 10 ³	99.9

By adding herbal extracts and propolis composed of each herbal medicine with various effects as above to toothpaste, each herbal medicine and propolis synergize with each other to minimize stimulation of toothpaste, as well as the efficacy and feel of herbal medicine To improve the antibacterial and inflammation in the oral cavity to improve the sterilization power to keep the teeth and mouth clean, as well as to prevent and treat tooth decay and periodontitis can be obtained.

The present invention described above is not limited to the above-described embodiment, and those skilled in the art to which the present invention pertains that substitution, modification and conversion are possible without departing from the technical spirit of the present invention. It will be obvious.

The present invention is to prevent oral inflammation by the antimicrobial activity of the respective herbal ingredients by adding the herbal extract and herbal extracts containing medicinal herbs, such as Cheonggung, Angelica, white paper, peppermint, mugwort, licorice, pine needles, and honey. It can alleviate the stability of herbal medicines and change the color and scent of toothpaste even during long-term storage, and can increase the disinfection power to keep teeth and oral clean, and the feeling of use is excellent. There are many different effects.

Claims

Precipitated calcium carbonate and calcium hydrogen phosphate, which are abrasives for cleaning tooth surface; Aminocaproic acid and allantoinchlorohydroxyaluminum, which are agents for preventing periodontal disease and preventing inflammation; Sorbitol, glycerin and xylitol, as humectants to prevent coagulation; Polyethylenglycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum, which are binders for combining powder and liquid components; Sodium lauryl sulfate, which is a foaming agent for prompting dispersion and penetration of the active ingredient; Sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint and blue No. 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; Toothpaste composed of purified water, perforated, Angelica, white paper, peppermint, mugwort, licorice, herbal extracts including pine needles, herbal extracts with added propolis and toothpaste added with propolis.
The method of claim 1,

Herbal extract and toothpaste to which herbal extracts and propolis are added, characterized in that the content of herbal extracts and propolis is 0.2% to 1.0% by weight.
The method of claim 1,

15 to 25% by weight, Angelica 15 to 25%, white paper 15 to 25%, peppermint 5 to 15% by weight, mugwort 5 to 15% by weight, based on 100% by weight of the herbal extract and propolis added to the toothpaste Herbal extract and toothpaste added to propolis, characterized in that 2.5 to 7.5% by weight licorice, 2.5 to 7.5% by weight pine needles 5-15% by weight of propolis.