WO2015034252A1 - Toothpaste containing medicinal herb extract and propolis - Google Patents

Toothpaste containing medicinal herb extract and propolis Download PDF

Info

Publication number
WO2015034252A1
WO2015034252A1 PCT/KR2014/008247 KR2014008247W WO2015034252A1 WO 2015034252 A1 WO2015034252 A1 WO 2015034252A1 KR 2014008247 W KR2014008247 W KR 2014008247W WO 2015034252 A1 WO2015034252 A1 WO 2015034252A1
Authority
WO
WIPO (PCT)
Prior art keywords
toothpaste
propolis
weight
added
extract
Prior art date
Application number
PCT/KR2014/008247
Other languages
French (fr)
Korean (ko)
Inventor
어수옥
심재경
Original Assignee
주식회사 경방
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 경방 filed Critical 주식회사 경방
Publication of WO2015034252A1 publication Critical patent/WO2015034252A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988Honey; Royal jelly, Propolis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention is added to the traditional toothpaste for tooth whitening and plaque removal and suppression of periodontal disease by adding herbal extracts and propolis extracted from Cheongung, Angelica, white paper, peppermint, cedar, licorice, pine needles, as well as minimizing the stimulation of toothpaste Toothpaste with herbal extracts and propolis, which improves the feeling of use and improves disinfection of antibacterial and inflammation in the oral cavity, keeps teeth and oral clean, and prevents and treats tooth decay and periodontitis. It is about.
  • powdered tooth powder ( ⁇ : powdered toothpaste) has emerged.
  • the abrasive for the cleaning effect is the main component, the removal of plaque and rehabilitation are increased, but the polishing force is so high that when used in addition to toothpaste, side effects such as abrasion of the teeth are generated, and the current semi-solid to improve the Toothpaste has emerged.
  • the polishing degree can be adjusted to a desired level by controlling the content of the abrasive.
  • the extracts of plants whose efficacy has been confirmed in both East and West are applied to toothpaste in the form of essential oils and powders, which are used for the treatment and prevention of oral diseases.
  • the strong antibacterial action of propolis honey extract can suppress oral diseases.
  • Known major functional toothpaste techniques are as follows.
  • Publication No. 1996-0003712 relates to a toothpaste composition containing propolis, which discloses a toothpaste composition comprising 0.01 to 5.0% by weight, preferably 0.1 to 1.0% of propolis, and Publication No. 1997-0009782.
  • the present invention relates to a toothpaste composition containing propolis, which contains 5 to 15% by weight of alcoholic and water-soluble extracts of propolis in general toothpaste composition
  • Publication No. 1998-0008209 relates to a toothpaste composition.
  • a toothpaste composition containing 1.0% by weight and 0.01-5.0% by weight of green tea extract is described.
  • Publication No. 2000-0012139 relates to a propolis extract, which is carried out in gas chromatography using p-ethyl phenol as an internal standard.
  • Toothpaste composition for preventing and treating periodontal disease which contains licorice extract, allantoin, propolis, chitosan, and xyitol in a ratio of 1: 5 to 1: 6 by weight in aminocaproic acid and apatite chemotherapeutic agent components, which are common toothpaste compositions
  • a toothpaste composition is disclosed, and Publication No.
  • 2010-0117328 relates to a toothpaste containing a natural spearmint powder and a method for preparing the toothpaste.
  • the mixture of natural spearmint powder and propolis in a common toothpaste composition is 0.5- by weight. Toothpaste containing 5% natural spearmint powder is described. Publication No. 2011-01374 No.
  • a functional toothpaste composition wherein when 100 ml of toothpaste is used as the total weight, 15 g of briquettes powder, 30 g of bamboo salt, as an abrasive using natural fiber as a neutral tank (sodium bicarbonate) or a natural adsorption abrasive in the abrasive, 12g of sterile vinegar, 3g kaolin clay, 30g glycerin, 3g pine resin, 5g mulberry extract, 2g allantoin or propolis, 5 drops grapefruit seed extract, 2 drops lemon and 4 drops peppermint
  • a functional toothpaste composition is characterized by adjusting the total weight through the generation of moisture during the mixing process, and Publication No.
  • 2012-0053370 relates to a syrup preventive toothpaste composition containing a lead extract and a method for preparing the same Calcium 5-15 wt%, Glycerin 1-2 wt%, D-Solbitol solution 18.9-70.65 wt%, Polyethylene glycol 1-5 wt%, Silicon dioxide 7.0-15.0 wt%, Xylitol 0.01-1.0 wt%, Propolis 0.01-0.6 wt%, Stevioside 0.01-2.0 wt%, grapefruit seed extract 0.01-2.0 wt%, safflower seed oil 0.1-1.0 wt%, annual extract 5-9.5 wt%, willow extract
  • a rot preventive toothpaste composition using a lead extract composed of 0.1 to 5.0% by weight, 0.10 to 3.0% by weight of cocaidopropyl betaine, 0.01 to 2.0% by weight of DL-menthol and 10 to 18% by weight of purified water is described.
  • Conventional toothpaste contains an extract extracted from the leaves of Camellia family for the treatment of periodontal disease and various oral diseases, or extracts of various plant leaves or petals are used, but in this case, the effects of treatment and prevention of various oral diseases
  • the toothpaste is used for a long time, the color of the toothpaste is changed or the fragrance is changed, so the effectiveness of the medicament contained in the toothpaste is reduced, and there is a problem in that the toothpaste is inferior in marketability.
  • tea tree oil extracted from tea tree is used as a flavoring agent to remove plaque or gingivitis, but in this case, the amount of tea tree oil is limited to the appropriate level of flavor to be added to toothpaste. There was also a problem that was not easy to use.
  • the present invention is to suppress the deformation of the toothpaste as much as possible to solve the problems of the conventional toothpaste as described above, and to provide a toothpaste with a herbal extract and propolis added with less stimulation and improved efficacy and usability. have.
  • the present invention has been invented to solve the above problems, precipitated calcium carbonate and calcium hydrogen phosphate which is an abrasive for cleaning the tooth surface; Aminocaproic acid and allantoinchlorohydroxyaluminum, which are agents for preventing periodontal disease and preventing inflammation; Sorbitol, glycerin and xylitol, as humectants to prevent coagulation; Polyethylene glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum, which are binders for combining powder and liquid components; Sodium lauryl sulfate, which is a foaming agent for prompting dispersion and penetration of the active ingredient; Sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil and food coloring blue 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; Toothpaste prepared with purified water provides perforated, Angelica, white paper, peppermint, cedar, licorice,
  • the present invention relates to a toothpaste for whitening teeth, removing plaque and suppressing periodontal disease.
  • Amino acid a pharmaceutical agent for preventing precipitated calcium carbonate and calcium hydrogen phosphate, and periodontal disease, which is an abrasive for cleaning the surface of teeth.
  • Caproic acid allantoinchlorohydroxyaluminum, sorbitol, glycerol, xylitol, wetting agent to prevent coagulation, polyethylenglycol (PEG), carboxymethylcellulose (CMC), xanthan gum, Sodium lauryl sulfate, a foaming agent for rapid dispersing and penetration of ingredients, and sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil, and food coloring, blue 1, which are additives to suppress the growth of microorganisms and improve the feeling of use.
  • toothpaste containing perforated, Angelica, white paper, peppermint, mugwort, licorice, pine needles It relates to herbal extracts and propolis added to the herbal extracts and propolis added toothpaste.
  • the abrasive is a component that acts to clean the dry surface of the tooth and is composed of precipitated calcium carbonate and calcium hydrogen phosphate.
  • the drug is used to sterilize the bacteria in the oral cavity, inhibit the production of plaque, and remove the generated plaque. It is composed of aminocaproic acid and allantoinchlorohydroxyaluminum.
  • the humectant is an essential ingredient to make the semi-solid form of toothpaste. It prevents the toothpaste from drying and solidifying when exposed to the air. It is composed of sorbitol, glycerin and xylitol. .
  • the binder used in semi-solid toothpaste is composed of polyethylen glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum because it plays a role of preventing the solid powder component and the liquid component from being separated.
  • PEG polyethylen glycol
  • CMC carboxymethyl cellulose
  • xanthan gum because it plays a role of preventing the solid powder component and the liquid component from being separated.
  • the foaming agent which quickly disperses and penetrates the active ingredients and reduces the interfacial tension, easily removes foreign substances in the oral cavity, and is composed of sodium lauryl sulfate, an anionic surfactant, and an additive for improving the feel of toothpaste.
  • herbal extracts including perforated, Angelica, white paper, peppermint, evergreen mugwort, licorice, pine needles, and propolis are added to the toothpaste containing purified water in the above components.
  • Efficacy and ingredients of each herbal medicine as described above are as follows.
  • Cheonggung is a root stem of perennial herbaceous perennial herb and cheoncheongung belonging to the Araaceae family. It is a representative medicine of live blood medicinal herbs. It helps smooth circulation of Qi and blood. Has antibacterial function
  • Angelica is a root of perennial herbaceous Angelica belonging to the Apiaceae, which is used as a representative herbal medicine of blood donor, which improves blood flow and improves flow, so it is used for pain caused by anemia or bleeding disorder. It is effective in treating tooth pain caused by or eliminating bad breath.
  • the white paper is the root of copper leaf, a perennial herb belonging to the Apiaceae, which is a representative herbal medicine of analgesics and is useful for alleviating various pains.
  • the fourth mint is a perennial herb, a perennial herb that belongs to the Lamiaceae. Its fragrance is very good and strong. When used in addition to toothpaste, it has an excellent effect on the removal of odor from the mouth. It also has antiseptic and antiseptic effect.
  • mugwort is dried dried outpost of chrysanthemums belonging to the chrysanthemum family. It is also used to improve moist heat and to treat jaundice, and when used in toothpaste, it can get excellent antibacterial effect against oral disease-causing bacteria.
  • licorice is the root of licorice, a perennial herb belonging to the legume, and is used as an antidote for all poisoning. It is very useful not only for herbal medicine but also for new medicine and folk medicine.
  • pine needles are extracted from pine leaves, rich in oxygen and minerals.
  • phytoncide contained in pine needles is antibacterial and terpene inhibits oxidation, causing pain when gums are sore and painful. It is effective in alleviating bad breath and removing bad breath caused by tooth decay and periodontal disease.
  • Propolis a natural antibiotic called nature's penicillin, also contains white blood cells to fight off bacteria that enter the body. It is a substance secreted by itself.
  • Propolis is used as a raw material for antibacterial, antiviral, antiseptic, antifungal, and antibiotics. Since it is not harmful to the human body, it has no side effects or resistance and is effective for treating wounds and ulcers inside and outside the body. It also prevents and improves the skin. Numerous studies and treatments have demonstrated the effectiveness of propolis to enhance immune tissues. In particular, flavonoids, a type of antioxidant contained in propolis, are known as a major component directly related to the body's immune system.
  • Propolis which is called natural antibiotic, has various functions such as skin antioxidant effect, anti-inflammatory and whitening.
  • the propolis may be referred to as a flavonoid which is the most important substance among the components of the propolis.
  • Dr. UHVillanueva discovered 18 species of flavonoids in propolis, and announced that it contained antibiotics such as Galantina and Piocemorina. It is revealed that this flavonoid ingredient can keep the genus sterile.
  • Flavonoids are widely distributed in the plant system, and most of them are present as glycosides, but most of the characteristics of flavonoids found in propolis are hydrolyzed and present in the form of aglycons.
  • This non-sugar sugar flavonoid is absorbed by the human body, which is characterized by the action of inhibiting the reaction of specific enzymes (antioxidant action), strengthening cell membranes, making the skin healthy and beautiful, and strengthening connective tissues ( Cell regeneration), antiallergic action and inhibition of the release of chemicals in mast cells that cause allergies, strengthening the production of phagocytes or antibodies in the body, regulating the immune system of body tissues to enhance antirheumatics, anti-AIDS, etc. It promotes the immune system of the whole body and increases resistance to infection.
  • the herbal extracts and propolis were prepared using a solution extraction method using a known herbal extraction method, the specific method is as follows.
  • the content of the herbal extract and propolis in 100% by weight of the herbal extract and propolis to which the present invention is added is preferably 0.2% by weight to 1.0% by weight, and more preferably 0.2% by weight to 0.4% by weight.
  • the content of herbal extracts and propolis is lower than 0.2% by weight, the efficacy of the toothpaste according to the present invention is insufficient, and when the content exceeds 1.0% by weight, the cost is excessively increased compared to the efficacy of the toothpaste, and it is half the taste or smell. It was felt that the experiment was undesirable.
  • each component for 100% by weight of herbal extracts and propolis is 15-25% by weight Cheongung, 15-25% by weight Angelica, 15-25% by weight white paper, 5-15% by weight peppermint 5-15 It is composed of weight%, licorice 2.5-7.5% by weight, pine needles 2.5-7.5% by weight, propolis 5-15% by weight.
  • Example 1 shows a method of preparing a toothpaste mainly on the content ratio of the general toothpaste composition and the additional herbal medicines added according to the present invention.
  • the binder was previously prepared by dispersing the binder in the mixed wetting agent, and the other ingredients (pharmaceuticals, additives, herbal extracts) were dispersed and mixed, and then the abrasive was added and stirred for about 30 minutes.
  • the humectant is composed of 30g of sorbitol, 5g of glycerin, 10g of xylitol and the binder is composed of 0.5g of PEG, 1g of CMC, and 0.3g of xanthan gum.
  • the drug consists of 0.1 g of aminocaproic acid, 0.08 g of allantoin chlorohydroxyaluminum, and 0.01 g of sodium benzoate,
  • the additive consists of 11g of green tea extract, 1g of saccharin sodium, 7g of menthol, 8g of peppermint oil, 1.07g of blue No. 1 (edible pigment),
  • Purified water consists of 10 g.
  • the abrasive is composed of precipitated calcium carbonate 14.55g, calcium hydrogen phosphate 0.08g and the foaming agent is composed of 0.01g sodium lauryl sulfate.
  • the herbal medicines included in the herbal extracts are: 0.06g Cheonung, Angelica 0.06g, white paper 0.06g, peppermint 0.03g, cauliflower 0.03g, licorice 0.015g, pine needles It is composed of 0.015g and 0.030g of propolis, the content of each component for 100% by weight of herbal extract and propolis is 20% by weight, Angelica 20% by weight, 20% by weight of white paper, 10% by weight of peppermint, 10% by weight of cedar %, Licorice 5% by weight, pine needles 5% by weight Propolis 10% by weight.
  • each herbal medicine and propolis synergize with each other to minimize stimulation of toothpaste, as well as the efficacy and feel of herbal medicine
  • To improve the antibacterial and inflammation in the oral cavity to improve the sterilization power to keep the teeth and mouth clean, as well as to prevent and treat tooth decay and periodontitis can be obtained.
  • the present invention is to prevent oral inflammation by the antimicrobial activity of the respective herbal ingredients by adding the herbal extract and herbal extracts containing medicinal herbs, such as Cheonggung, Angelica, white paper, peppermint, mugwort, licorice, pine needles, and honey. It can alleviate the stability of herbal medicines and change the color and scent of toothpaste even during long-term storage, and can increase the disinfection power to keep teeth and oral clean, and the feeling of use is excellent. There are many different effects.
  • medicinal herbs such as Cheonggung, Angelica, white paper, peppermint, mugwort, licorice, pine needles, and honey.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a traditional Korean medicinal toothpaste containing a medicinal herb extract and propolis, wherein a medicinal herb extract extracted from Cnidium officinale Makino, Angelica gigas Nakai, Angelica dahurica Benth, Mentha arvensis L., Artemisia capillaris Thunberg, Glycyrrhiza uralensis Fischer and pine needles is added to a toothpaste for tooth whitening, plaque removal and periodontal disease inhibition, thereby minimizing the irritation of a toothpaste, improving the efficacy and feeling of use of medicinal herbs, and enhancing sterilization for the antibacterial effect and inflammation prevention inside the mouth so as to hygienically maintain the teeth and the mouth and prevent and treat cavities and periodontitis. According to the present invention, provided is a traditional Korean medicinal toothpaste containing a medicinal herb extract and propolis, wherein a medicinal herb extract comprising Cnidium officinale Makino, Angelica gigas Nakai, Angelica dahurica Benth, Mentha arvensis L., Artemisia capillaris Thunberg, Glycyrrhiza uralensis Fischer and pine needles and propolis are added to a toothpaste comprising: precipitated calcium carbonate and calcium hydrogen phosphate as an abrasive for polishing the outer surface of the teeth; aminocaproic acid and aluminum chlorohydroxy allantoinate, which are agents for preventing periodontal diseases and inflammation; sorbitol, glycerin and xylitol, which are wetting agents for preventing solidification; polyethylene glycol (PEG), carboxymethyl cellulose (CMC) and xanthan gum, which are binders for binding a powder and a liquid ingredient; sodium lauryl sulfate which is a foaming agent for allowing medicinal ingredients to be dispersed and penetrated rapidly; sodium benzoate, a green tea extract, sodium saccharin, menthol, peppermint oil and blue No. 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; and purified water.

Description

한방추출물과 프로폴리스가 첨가된 치약Toothpaste with Herbal Extract and Propolis
본 발명은 치아 미백과 프라그 제거 및 치주질환을 억제하기 위한 통상적인 치약에 천궁, 당귀, 백지, 박하, 사철쑥, 감초, 솔잎으로부터 추출한 한약재추출물과 프로폴리스를 첨가하여 치약의 자극을 최소화함은 물론이고, 사용감을 개선하며 구강내의 항균 및 염증 예방을 위한 살균력을 향상시켜 치아 및 구강을 청결하게 유지할 수 있을 뿐만 아니라, 충치 및 치주염을 예방하며 치료하는 기능을 가지는 한방추출물과 프로폴리스가 첨가된 치약에 관한 것이다.The present invention is added to the traditional toothpaste for tooth whitening and plaque removal and suppression of periodontal disease by adding herbal extracts and propolis extracted from Cheongung, Angelica, white paper, peppermint, cedar, licorice, pine needles, as well as minimizing the stimulation of toothpaste Toothpaste with herbal extracts and propolis, which improves the feeling of use and improves disinfection of antibacterial and inflammation in the oral cavity, keeps teeth and oral clean, and prevents and treats tooth decay and periodontitis. It is about.
치약이 존재하기 이전시대에는 식물의 줄기나 잎 등으로 치아를 문질러서 양치를 하였으나 프라그의 제거 및 세정효과가 미흡하였다.Before toothpaste, teeth were rubbed with the stems and leaves of plants, but the removal and cleaning effect of plaque was insufficient.
따라서 이를 개선하기 위하여 분말가루형태의 치분(齒紛: 가루로 된 치약)이 등장하게 되었다.Therefore, in order to improve this, powdered tooth powder (가루: powdered toothpaste) has emerged.
그러나 상기 치분의 경우 세정효과를 위한 연마제가 주성분으로, 프라그 제거 및 세정교화는 증가하였지만 연마력이 지나치게 높아서 치약에 첨가하여 사용할 경우 치아를 마모시키는 등의 부작용이 발생되어 이를 개선하기 위한 현재의 반고형 치약이 등장하게 되었다.However, in the case of the tooth powder, the abrasive for the cleaning effect is the main component, the removal of plaque and rehabilitation are increased, but the polishing force is so high that when used in addition to toothpaste, side effects such as abrasion of the teeth are generated, and the current semi-solid to improve the Toothpaste has emerged.
이와 같은 현재의 치약은 연마제와 함께 반고형의 형태를 유지하기 위하여 습윤제가 포함되어 있기 때문에 연마제의 함량을 조절하여 연마도를 원하는 수준으로 조정할 수 있다.Since the current toothpaste contains a humectant to maintain a semi-solid form together with the abrasive, the polishing degree can be adjusted to a desired level by controlling the content of the abrasive.
이 밖에 현대 치약은 프라그 제거와 치아 세정이라는 기본 기능 이외에도 충치, 치은염, 구취, 미백 등과 같은 다양한 구강질환의 치료와 예방을 위하여 여러 가지 약효제 및 한약재를 사용함으로써 구강위생 개선에 기여하고 있다.In addition to the basic functions of plaque removal and tooth cleaning, modern toothpaste contributes to improving oral hygiene by using various medicinal agents and herbal medicines for the treatment and prevention of various oral diseases such as tooth decay, gingivitis, bad breath, and whitening.
특히 동서양을 막론하고 효능이 확인된 식물의 추출물을 정유 및 분말 형태로 치약에 적용하여 구강질환의 치료 및 예방에 사용하고 있다. 또한 벌꿀 추출물인 프로폴리스의 강력한 항균 작용을 통해 구강 질환을 억제할 수 있다.In particular, the extracts of plants whose efficacy has been confirmed in both East and West are applied to toothpaste in the form of essential oils and powders, which are used for the treatment and prevention of oral diseases. In addition, through the strong antibacterial action of propolis honey extract can suppress oral diseases.
알려진 주요 기능성 치약에 관한 기술들은 다음과 같다. 공개번호 특1996-0003712호에는 프로폴리스를 함유한 치약조성물에 관한 것으로 프로폴리스를 0.01 내지 5.0중량%, 바람직하게는 0.1 내지 1.0% 포함하는 치약조성물이 기재되어 있고, 공개번호 특1997-0009782호에는 프로폴리스가 함유된 치약조성물에 관한 것으로 일반 치약조성물에 프로폴리스의 알코올성 추출물 및 수용성 추출물을 5~15중량% 포함한 것이며, 공개번호 특1998-0008209호는 치약조성물에 관한 것으로 자몽종자 추출물 0.005 내지 1.0중량% 및 녹차추출물 0.01 내지 5.0중량%를 함유하는 치약조성물이 기재되어 있으며, 공개번호 특2000-0012139호는 프로폴리스 추출물에 관한 것으로, 내부표준으로서 p-에틸 페놀을 사용하는 가스 크로마토그래피에 의해 측정된, p-에틸 페놀에 대한 상대 체류시간이 0.7∼0.8인 냄새성분의 함유량 및/또는 상기와 마찬가지로 하여 측정된 상대 체류시간이 1.2∼1.3인 다른 냄새성분의 함유량이 감소된 프로폴리스 추출물에 관한 기술이며, 공개번호 2006-0108917호는 잇몸사랑 한방 치약에 관한 것으로 치주질환 예방과 치료효과를 나타내는 치약 조성물에 있어서 일반적인 치약 조성물인 아미노카프론산, 아파타이트 화학요법 제제 성분에 감초엑기스, 알란토인, 프로폴리스, 키토산, 자이리톨을 중량 기준으로 1:5 내지 1:6 비율로 함유하는 치주질환 예방과 치료용 치약조성물이 기재되어 있으며, 공개번호 2010-0117328호는 천연 스피어민트 분말이 함유된 치약 및 그 치약의 제조방법에 관한 것으로 통상의 치약 조성물에 천연 스피어민트 분말과 프로폴리스가 혼합된 혼합체를 중량비로 0.5-5% 함유시킨 천연 스피어민트 분말이 함유된 치약이 기재되어 있으며, 공개번호 2011-0137451호는 기능성 치약 조성물에 관한 것으로 치약 용량 100ml을 전체중량으로 할 때, 연마제 중 중조(탄산수소나트륨) 또는 천연 흡착 연마제로 천연 섬유질을 활용한 연마제로서 옷수수속대 분말 15g과, 죽염 30g과, 살균용 오디 식초 12g과, 카올린클레이 3g과, 글리세린 30g과, 송진가루 3g과, 오디 추축액 5g과, 알란토인 또는 프로폴리스 2g을 자몽씨 추출물 5방울과, 레몬 2방울 및 페파민트 4방울에 혼합하여 혼합공정중 수분의 발생을 통해 전체 중량을 맞추는 것을 특징으로 하는 기능성 치약 조성물이 기재되어 있으며, 공개번호 2012-0053370호는 연 추출물을 함유하는 시린이 예방 치약 조성물 및 그 제조방법에 관한 것으로 인산삼칼슘 5~15중량%, 글리세린 1~2중량%, D-솔비톨액 18.9~ 70.65중량%, 폴리에칠렌 글리콜 1~5중량%, 이산화규소 7.0~15.0중량%, 자일리톨 0.01~1.0중량%, 프로폴리스 0.01~0.6 중량%, 스테비오사이드 0.01~2.0중량%, 자몽종자추출물 0.01~2.0중량%, 홍화씨유 0.1~1.0 중량%, 연 추출물5~9.5중량%, 버드나무추출물 0.1~5.0중량%, 코카마이도프로필베타인 0.10~3.0중량%, DL-멘톨 0.01~2.0 중량% 및 정제수 10~ 18 중량%로 조성된 연 추출물을 이용한 시린이 예방 치약 조성물이 기재되어 있다.Known major functional toothpaste techniques are as follows. Publication No. 1996-0003712 relates to a toothpaste composition containing propolis, which discloses a toothpaste composition comprising 0.01 to 5.0% by weight, preferably 0.1 to 1.0% of propolis, and Publication No. 1997-0009782. The present invention relates to a toothpaste composition containing propolis, which contains 5 to 15% by weight of alcoholic and water-soluble extracts of propolis in general toothpaste composition, and Publication No. 1998-0008209 relates to a toothpaste composition. A toothpaste composition containing 1.0% by weight and 0.01-5.0% by weight of green tea extract is described. Publication No. 2000-0012139 relates to a propolis extract, which is carried out in gas chromatography using p-ethyl phenol as an internal standard. Content of odor component with relative residence time of p-ethyl phenol of 0.7 to 0.8 and / or the same as above. This is a technique for extracting propolis with reduced content of other odor components with relative residence time of 1.2 to 1.3. Publication No. 2006-0108917 relates to gum love herbal toothpaste, which shows prevention and treatment of periodontal disease. Toothpaste composition for preventing and treating periodontal disease, which contains licorice extract, allantoin, propolis, chitosan, and xyitol in a ratio of 1: 5 to 1: 6 by weight in aminocaproic acid and apatite chemotherapeutic agent components, which are common toothpaste compositions A toothpaste composition is disclosed, and Publication No. 2010-0117328 relates to a toothpaste containing a natural spearmint powder and a method for preparing the toothpaste. The mixture of natural spearmint powder and propolis in a common toothpaste composition is 0.5- by weight. Toothpaste containing 5% natural spearmint powder is described. Publication No. 2011-01374 No. 51 relates to a functional toothpaste composition, wherein when 100 ml of toothpaste is used as the total weight, 15 g of briquettes powder, 30 g of bamboo salt, as an abrasive using natural fiber as a neutral tank (sodium bicarbonate) or a natural adsorption abrasive in the abrasive, 12g of sterile vinegar, 3g kaolin clay, 30g glycerin, 3g pine resin, 5g mulberry extract, 2g allantoin or propolis, 5 drops grapefruit seed extract, 2 drops lemon and 4 drops peppermint A functional toothpaste composition is characterized by adjusting the total weight through the generation of moisture during the mixing process, and Publication No. 2012-0053370 relates to a syrup preventive toothpaste composition containing a lead extract and a method for preparing the same Calcium 5-15 wt%, Glycerin 1-2 wt%, D-Solbitol solution 18.9-70.65 wt%, Polyethylene glycol 1-5 wt%, Silicon dioxide 7.0-15.0 wt%, Xylitol 0.01-1.0 wt%, Propolis 0.01-0.6 wt%, Stevioside 0.01-2.0 wt%, grapefruit seed extract 0.01-2.0 wt%, safflower seed oil 0.1-1.0 wt%, annual extract 5-9.5 wt%, willow extract A rot preventive toothpaste composition using a lead extract composed of 0.1 to 5.0% by weight, 0.10 to 3.0% by weight of cocaidopropyl betaine, 0.01 to 2.0% by weight of DL-menthol and 10 to 18% by weight of purified water is described.
발명의 요약Summary of the Invention
종래의 치약은 치주질환 및 각종 구강질환의 치료를 목적으로 동백나무과 식물의 잎에서 추출한 추출물을 함유하거나 각종 식물잎이나 꽃잎 등의 추출물이 사용되고 있으나 이 경우, 각종 구강질환의 치료 및 예방의 효과는 있지만 치약을 장기간 사용 시 치약의 색상이 변질되거나 향이 변화되면서 치약에 함유된 약효제의 효과가 감소되고 사용 시 불쾌감을 유발하는 등 치약의 상품성이 떨어지는 문제점이 있었다.Conventional toothpaste contains an extract extracted from the leaves of Camellia family for the treatment of periodontal disease and various oral diseases, or extracts of various plant leaves or petals are used, but in this case, the effects of treatment and prevention of various oral diseases However, when the toothpaste is used for a long time, the color of the toothpaste is changed or the fragrance is changed, so the effectiveness of the medicament contained in the toothpaste is reduced, and there is a problem in that the toothpaste is inferior in marketability.
또한 프라그 제거나 치은염의 치료효과를 높이기 위한 향미제로서 차나무로부터 추출 정제한 차나무 오일이 사용되고 있으나 이 경우 차나무 오일의 사용량이 적당한 향미를 구현하는 함량수준에서 그 사용량이 제한될 수 밖에 없으므로 치약에 첨가하여 사용하는 것이 용이하지 못한 문제점도 있었다.In addition, tea tree oil extracted from tea tree is used as a flavoring agent to remove plaque or gingivitis, but in this case, the amount of tea tree oil is limited to the appropriate level of flavor to be added to toothpaste. There was also a problem that was not easy to use.
따라서 본 발명은 상기와 같은 종래의 치약의 문제점을 해소할 수 있도록 치약의 변형을 최대한 억제하고, 자극이 적으면서도 효능 및 사용감을 개선시킨 한방추출물과 프로폴리스가 첨감된 치약을 제공함에 그 목적이 있다.Therefore, the present invention is to suppress the deformation of the toothpaste as much as possible to solve the problems of the conventional toothpaste as described above, and to provide a toothpaste with a herbal extract and propolis added with less stimulation and improved efficacy and usability. have.
본 발명은 상기와 같은 문제점을 해소하기 위하여 발명된 것으로, 치아 겉표면을 세정하기 위한 연마제인 침강탄산칼슘과 인산수소칼슘; 치주질환을 예방하고 염증을 방지하기 위한 약효제인 아미노카프론산과 알란토인클로로히드록시알루미늄; 응고를 막기 위한 습윤제인 솔비톨과 글리세린과 자일리톨; 분말과 액체성분을 결합하기 위한 결합제인 폴리에틸렌클리콜(PEG)과 카르복시메틸셀룰로오스(CMC)와 산탄검; 약효성분의 분산 및 침투를 신속하게 하기 위한 기포제인 라우릴황산나트륨; 미생물의 생육을 억제하고 사용감을 좋게 하기 위한 첨가제인 안식향산나트륨과 녹차추출물과 삭카린나트륨과 멘톨과 페퍼민트유와 식용색소인 청색1호; 정제수로 제조된 치약 에 천공, 당귀, 백지, 박하, 사철쑥, 감초, 솔잎을 포함하는 한방추출물과 프로폴리스가 첨가된 것을 특징으로 하는 한방추출물과 프로폴리스가 첨가된 치약을 제공한다.The present invention has been invented to solve the above problems, precipitated calcium carbonate and calcium hydrogen phosphate which is an abrasive for cleaning the tooth surface; Aminocaproic acid and allantoinchlorohydroxyaluminum, which are agents for preventing periodontal disease and preventing inflammation; Sorbitol, glycerin and xylitol, as humectants to prevent coagulation; Polyethylene glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum, which are binders for combining powder and liquid components; Sodium lauryl sulfate, which is a foaming agent for prompting dispersion and penetration of the active ingredient; Sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil and food coloring blue 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; Toothpaste prepared with purified water provides perforated, Angelica, white paper, peppermint, cedar, licorice, herbal extracts including pine needles, and herbal extracts and propolis added to the propolis is added.
발명의 상세한 설명 및 구체적인 구현예Detailed Description of the Invention and Specific Embodiments
본 발명은 치아 미백과 프라그 제거 및 치주질환을 억제하기 위한 치약에 관한 것으로, 치아 겉표면을 세정하기 위한 연마제인 침강탄산칼슘과 인산수소칼슘과 치주질환을 예방하고 염증을 방지하기 위한 약효제인 아미노카프론산과 알란토인클로로히드록시알루미늄과 응고를 막기 위한 습윤제인 솔비톨과 글리세린과 자일리톨과 분말과 액체성분을 결합하기 위한 결합제인 폴리에틸린글리콜(PEG)과 카르복시메틸셀룰로오스(CMC)와 산탄검과 약효성분의 분산 및 침투를 신속하게 하기 위한 기포제인 라우릴황산나트륨과 미생물의 생육을 억제하고 사용감을 좋게하기 위한 첨가제인 안식향산나트륨과 녹차추출물과 삭카린나트륨과 멘톨과 페퍼민트유와 식용색소인 청색1호와 정제수로 구성된 치약에 천공, 당귀, 백지, 박하, 쑥, 감초, 솔잎을 포함하는 한방추출물과 프로폴리스가 첨가된 한방추출물과 프로폴리스가 첨가된 치약에 관한 것이다.The present invention relates to a toothpaste for whitening teeth, removing plaque and suppressing periodontal disease. Amino acid, a pharmaceutical agent for preventing precipitated calcium carbonate and calcium hydrogen phosphate, and periodontal disease, which is an abrasive for cleaning the surface of teeth. Caproic acid, allantoinchlorohydroxyaluminum, sorbitol, glycerol, xylitol, wetting agent to prevent coagulation, polyethylenglycol (PEG), carboxymethylcellulose (CMC), xanthan gum, Sodium lauryl sulfate, a foaming agent for rapid dispersing and penetration of ingredients, and sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint oil, and food coloring, blue 1, which are additives to suppress the growth of microorganisms and improve the feeling of use. And toothpaste containing perforated, Angelica, white paper, peppermint, mugwort, licorice, pine needles It relates to herbal extracts and propolis added to the herbal extracts and propolis added toothpaste.
상기 연마제는 치아의 건표면을 세정하는 작용을 하는 성분으로써 침강탄산칼슘과 인산수소칼슘으로 구성되어 있다.The abrasive is a component that acts to clean the dry surface of the tooth and is composed of precipitated calcium carbonate and calcium hydrogen phosphate.
그리고 약효제는 구강 내 세균을 살균하며 프라그의 생성을 억제하고 생성된 프라그를 제거하는 작용을 하는 성분으로 아미노카프론산과 알란토인클로로히드록시알루미늄으로 구성된다.The drug is used to sterilize the bacteria in the oral cavity, inhibit the production of plaque, and remove the generated plaque. It is composed of aminocaproic acid and allantoinchlorohydroxyaluminum.
또한, 습윤제는 치약의 반고형 형태를 만들기 위한 필수성분으로 치약이 공기중에 노출될 때 건조 및 고체화되는 것을 방지하며 치약의 표면에 윤기를 주는 작용을 하는 성분으로 솔비톨과 글리세린과 자일리톨로 구성되어 있다.In addition, the humectant is an essential ingredient to make the semi-solid form of toothpaste. It prevents the toothpaste from drying and solidifying when exposed to the air. It is composed of sorbitol, glycerin and xylitol. .
그리고 고체인 분말 성분과 액체 성분이 분리되지 않게 해주는 역할을 하므로 반고형의 치약에서는 필수적으로 사용되는 결합제는 폴리에틸린글리콜(PEG)과 카르복시메틸셀룰로오스(CMC)와 산탄검으로 구성된다.In addition, the binder used in semi-solid toothpaste is composed of polyethylen glycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum because it plays a role of preventing the solid powder component and the liquid component from being separated.
이 밖에 약효 성분의 분산 및 침투를 신속하게 하고 계면장력을 감소시킴으로서 구강내 이물질을 쉽게 떨어지게 하는 작용을 하는 기포제는 음이온성계면활성제인 라우릴황산나트륨으로 구성되며, 치약의 사용감을 좋게하기 위한 첨가제는 안식향산나트륨과 녹차추출물과 삭카린나트륨과 멘톨과 페퍼민트유로 구성되어 있다.In addition, the foaming agent, which quickly disperses and penetrates the active ingredients and reduces the interfacial tension, easily removes foreign substances in the oral cavity, and is composed of sodium lauryl sulfate, an anionic surfactant, and an additive for improving the feel of toothpaste. Sodium benzoate, green tea extract, sodium saccharin, menthol and peppermint oil.
상기와 같은 구성성분에 정제수가 함유된 치약에 한약재인 천공, 당귀, 백지, 박하, 사철쑥, 감초, 솔잎을 포함하는 한방추출물과 프로폴리스가 첨가된 것이 본 발명의 특징이다. 상기와 같은 각각의 한약재가 가지고 있는 효능 및 성분은 다음과 같다.It is a feature of the present invention that herbal extracts including perforated, Angelica, white paper, peppermint, evergreen mugwort, licorice, pine needles, and propolis are added to the toothpaste containing purified water in the above components. Efficacy and ingredients of each herbal medicine as described above are as follows.
첫 번째로 천궁은 미나리과에 속한 다년생초본인 천궁 및 일천궁의 뿌리줄기로서 활혈거어약류에서 대표적인 약으로서 기와 혈의 원활한 순환을 도우며 몸 안으로 침입한 풍의 기운을 없애는 동시에 지통의 효과가 있으며 세정기능 및 항균기능을 가지고 있다.Firstly, Cheonggung is a root stem of perennial herbaceous perennial herb and cheoncheongung belonging to the Araaceae family. It is a representative medicine of live blood medicinal herbs. It helps smooth circulation of Qi and blood. Has antibacterial function
따라서 치약에 첨가하여 사용할 경우 치아의 겉표면에 생성되는 프라그의 예방과 생성된 프라그의 제거에 효과적이며 치통을 완화하는 효과도 있다.Therefore, when used in addition to toothpaste is effective in the prevention of plaque generated on the outer surface of the tooth and the removal of the generated plaque, it also has the effect of relieving toothache.
두 번째로 당귀는 미나리과에 속하는 다년생초본 당귀의 뿌리로서 보혈제의 대표적인 생약으로 혈을 보하고 흐름을 좋게 하므로 빈혈이나 어혈로 인한 형행 장애에서 오는 동통증에 활용되고 있으며, 치약에 첨가하여 사용할 경우 풍으로 인한 치아의 통증을 치료하거나 구취를 없애는데 탁월한 효과가 있다.Secondly, Angelica is a root of perennial herbaceous Angelica belonging to the Apiaceae, which is used as a representative herbal medicine of blood donor, which improves blood flow and improves flow, so it is used for pain caused by anemia or bleeding disorder. It is effective in treating tooth pain caused by or eliminating bad breath.
세 번째로 백지는 미나리과에 속하는 다년생초본인 구릿대의 뿌리로서 진통제의 대표적인 생약으로 각종 통증을 완화하는데 유용하다.Thirdly, the white paper is the root of copper leaf, a perennial herb belonging to the Apiaceae, which is a representative herbal medicine of analgesics and is useful for alleviating various pains.
네 번재로 박하는 꿀풀과에 속한 다년생초본인 박하의 지상부전초로서 향기가 매우 좋고 강하며, 치약에 첨가하여 사용할 경우 구내의 악취제거에 탁월한 효과가 있으며 살균 및 방부의 효과도 있다.The fourth mint is a perennial herb, a perennial herb that belongs to the Lamiaceae. Its fragrance is very good and strong. When used in addition to toothpaste, it has an excellent effect on the removal of odor from the mouth. It also has antiseptic and antiseptic effect.
다섯 번째로 쑥은 국화과에 속한 사철쑥의 전초를 건조한 것으로 인진이라고도 하며 습열을 제고하고 황달을 치료하는데 사용되며 치약에 첨가하여 사용할 경우 구강병 원인균에 대한 우수한 항균효과를 얻을 수 있다.Fifth, mugwort is dried dried outpost of chrysanthemums belonging to the chrysanthemum family. It is also used to improve moist heat and to treat jaundice, and when used in toothpaste, it can get excellent antibacterial effect against oral disease-causing bacteria.
여섯 번째로 감초는 콩과에 속한 다년생초본인 감초의 뿌리로서 모든 중독의 해독제로 사용되고 있으며, 한방뿐만 아니라 신약, 민간약으로도 아주 유용하게 쓰이고 있다.Sixth, licorice is the root of licorice, a perennial herb belonging to the legume, and is used as an antidote for all poisoning. It is very useful not only for herbal medicine but also for new medicine and folk medicine.
이 밖에 치약에 첨가하여 사용할 경우 감초에 포함되어 있는 리코리시딘과 리코리소플라반이라는 두가지 항균물질이 충치와 잇몸질환을 일으키는 주된 구강 박테리아를 죽이는 역할을 하므로 충치 및 잇몸질환을 치료하고 나아가 구강감염을 예방하는데 효과적이다.In addition, when used in addition to toothpaste, two antibacterial substances in licorice, Licorisidine and Licolyoflavan, are responsible for killing the main oral bacteria that cause tooth decay and gum disease. Effective in preventing
마지막으로 솔잎은 소나무의 잎에서 추출된 성분으로서 산소와 미네랄이 풍부하며 치약에 첨가하여 사용할 경우 솔잎에 함유되어 있는 피톤치드 성분이 항균 작용을 하고 테르펜 성분이 산화작용을 억제하여 잇몸이 시리고 아플 때 통증을 완화하는 효과가 있으며 충치 및 치주질환으로 인한 입냄새의 제거에도 효과적이다.Lastly, pine needles are extracted from pine leaves, rich in oxygen and minerals. When used in toothpaste, phytoncide contained in pine needles is antibacterial and terpene inhibits oxidation, causing pain when gums are sore and painful. It is effective in alleviating bad breath and removing bad breath caused by tooth decay and periodontal disease.
또한 ‘자연의 페니실린’이라 불리기도 하는 천연 항생물질인 프로폴리스(propolis)는 인체에 침입한 세균을 물리치기 위해 백혈구가 있듯이, 나무들이 생장점을 보호하거나 상처 부위의 오염을 방지하고 미생물을 차단하기 위해 스스로 분비하는 물질이다.Propolis, a natural antibiotic called nature's penicillin, also contains white blood cells to fight off bacteria that enter the body. It is a substance secreted by itself.
프로폴리스는 항균제, 항바이러스제, 소독약제, 항진균제, 항생물질의 원료로 쓰이는데, 인체에 유해한 성분이 아니므로 부작용이나 내성이 전혀 없어서 인체 내부나 외부의 상처, 궤양 치료에 효과적이며, 장기 복용하면 감기도 예방되고 피부도 좋아진다. 수많은 연구와 치료를 통해 프로폴리스의 면역조직 강화효능이 입증되었다. 특히 프로폴리스에 함유된 항산화제의 일종인 플라보노이드(flavonoids)는 인체의 면역체계와 직접적으로 관련되는 주요 성분으로 알려져 있다.Propolis is used as a raw material for antibacterial, antiviral, antiseptic, antifungal, and antibiotics. Since it is not harmful to the human body, it has no side effects or resistance and is effective for treating wounds and ulcers inside and outside the body. It also prevents and improves the skin. Numerous studies and treatments have demonstrated the effectiveness of propolis to enhance immune tissues. In particular, flavonoids, a type of antioxidant contained in propolis, are known as a major component directly related to the body's immune system.
천연항생제로 불리는 프로폴리스는 피부 항산화효과, 항염증, 미백 등의 다양한 기능을 가지고 있다.Propolis, which is called natural antibiotic, has various functions such as skin antioxidant effect, anti-inflammatory and whitening.
여기서, 상기 프로 폴리스는 프로폴리스의 구성성분 중 가장 중요한 물질이 후라보노이드(Flavonoid)라고 할 수 있다. 1970년도에 구 소련의 과학아카데미에서 빌라누에바(U.H.Villanueva)박사는 프로폴리스속에 18종의 후라보노이드 성분이 들어 있음을 밝혀냈고, 그밖에 항생성분인 갈란지나 피오세모리나(Galangina Pinocemorina)가 들어있다고 발표함으로써 벌집 속이 무균상태를 유지할 수 있는 것은 바로 이 후라보노이드 성분 때문이라는 사실을 밝힌 바 있다.Herein, the propolis may be referred to as a flavonoid which is the most important substance among the components of the propolis. In 1970, at the former Soviet Academy of Sciences, Dr. UHVillanueva discovered 18 species of flavonoids in propolis, and announced that it contained antibiotics such as Galantina and Piocemorina. It is revealed that this flavonoid ingredient can keep the genus sterile.
후라보노이드는 식물계에 폭 넓게 분포되어 있으며 그 대부분은 배당 체(glycoside)로 존재하고 있으나 프로폴리스에서 발견되는 후라보노이드의 특징은 대부분 가수분해되어 비당분성(aglycon)의 형태로 존재하고 있다.Flavonoids are widely distributed in the plant system, and most of them are present as glycosides, but most of the characteristics of flavonoids found in propolis are hydrolyzed and present in the form of aglycons.
이 비당분성의 후라보이드는 우리 인체에 흡수되었을 때 나타나는 특징은 특정효소의 반응을 억제하는 작용(항산화작용), 세포막을 강화하는 작용으로 피부를 건강하고 아름답게 하는 미용작용, 결합조직의 강화작용(세포재생), 항 알레르기 작용과 알레르기를 일으키는 비만세포 내의 화학물질의 유리를 억제하는 작용, 체내의 식세포나 항체의 생성을 강화하여 신체조직의 면역력을 조절하여 항류마치스, 항에이즈 기능을 증강 하는 등 전반적인 생체의 면역기능을 촉진하여 감염에 대한 저항력을 높여준다.This non-sugar sugar flavonoid is absorbed by the human body, which is characterized by the action of inhibiting the reaction of specific enzymes (antioxidant action), strengthening cell membranes, making the skin healthy and beautiful, and strengthening connective tissues ( Cell regeneration), antiallergic action and inhibition of the release of chemicals in mast cells that cause allergies, strengthening the production of phagocytes or antibodies in the body, regulating the immune system of body tissues to enhance antirheumatics, anti-AIDS, etc. It promotes the immune system of the whole body and increases resistance to infection.
상기 한방추출물과 프로폴리스는 공지의 한방추출방법을 사용한 용액추출법을 사용하여 제조하였으며, 그 구체적인 방법은 다음과 같다. The herbal extracts and propolis were prepared using a solution extraction method using a known herbal extraction method, the specific method is as follows.
천궁 15~25중량%, 당귀 15~25중량%, 백지 15~25중량%, 박하 5~15중량%, 사철쑥 5~15중량%, 감초 2.5~7.5중량%, 솔잎 2.5~7.5중량%, 프로폴리스 5~15중량%의 혼합 원료 1000g에 물 1000g을 중탕기에 넣고 120~122℃, 압력 15psi로 3~4시간 정도 가열하여 유효 성분을 열수 추출한다. 15-25 weight% of celestial organs, 15-25 weight% of Angelica, 15-25 weight% of white paper, 5-15 weight% of peppermint, 5-15 weight% of cedar wormwood, licorice 2.5-7.5 weight%, pine needles 2.5-7.5 weight%, pro 1000 g of water is mixed with 1000 g of 5-15% by weight of mixed raw materials, and the hot water is extracted by heating at 120-122 ° C. and 15 psi for 3-4 hours.
본 발명의 한방추출물과 프로폴리스가 첨가된 치약 100중량% 중 한방추출물과 프로폴리스의 함량은 0.2중량% 내지 1.0중량%가 바람직하며 더욱 바람직하게는 0.2중량% 내지 0.4중량%를 포함하는 것이다. 한방추출물과 프로폴리스의 함량이 0.2중량% 보다 낮은 경우 본 발명에 의한 치약의 효능이 미흡하며, 1.0중량%를 초과하는 경우는 치약의 효능에 비하여 비용이 과다하게 증가하는 외에도 맛이나 냄새에 반감을 느끼게 되어 바람직하지 않은 것으로 실험되었다.The content of the herbal extract and propolis in 100% by weight of the herbal extract and propolis to which the present invention is added is preferably 0.2% by weight to 1.0% by weight, and more preferably 0.2% by weight to 0.4% by weight. When the content of herbal extracts and propolis is lower than 0.2% by weight, the efficacy of the toothpaste according to the present invention is insufficient, and when the content exceeds 1.0% by weight, the cost is excessively increased compared to the efficacy of the toothpaste, and it is half the taste or smell. It was felt that the experiment was undesirable.
그리고 한방추출물 및 프로폴리스 100중량%에 대한 각각 구성성분의 바람직한 함유량은 천궁 15~25중량%, 당귀 15~25중량%, 백지 15~25중량%, 박하 5~15중량%, 사철쑥 5~15중량%, 감초 2.5~7.5중량%, 솔잎 2.5~7.5중량%, 프로폴리스 5~15중량%로 구성된다.And the preferred content of each component for 100% by weight of herbal extracts and propolis is 15-25% by weight Cheongung, 15-25% by weight Angelica, 15-25% by weight white paper, 5-15% by weight peppermint 5-15 It is composed of weight%, licorice 2.5-7.5% by weight, pine needles 2.5-7.5% by weight, propolis 5-15% by weight.
여기서, 하기 실시예1은 일반적인 치약구성물과 본 발명에 따라 추가적으로 첨가되는 한약재들의 함량비를 중심으로 치약의 제조방법을 나타낸 것이다.Here, Example 1 shows a method of preparing a toothpaste mainly on the content ratio of the general toothpaste composition and the additional herbal medicines added according to the present invention.
실시예 1Example 1
1. 용제가 혼합된 습윤제에 결합제를 미리 분산하여 준비하고, 기타 성분들(약효제, 첨가제, 한방추출물)을 분산 혼합한 다음, 연마제를 투입하여 약 30분간 교반하였다.1. The binder was previously prepared by dispersing the binder in the mixed wetting agent, and the other ingredients (pharmaceuticals, additives, herbal extracts) were dispersed and mixed, and then the abrasive was added and stirred for about 30 minutes.
2. 이어서, 기포제를 투입한 후 진공 상태에서 20분간 교반시켜 최종 제품을 수득하였다.2. Then, the foaming agent was added and stirred for 20 minutes in a vacuum to obtain a final product.
이때, 상기 습윤제는 솔비톨 30g, 글리세린 5g, 자일리톨 10g으로 구성되고 상기 결합제는 PEG 0.5g, CMC 1g, 산탄검 0.3g으로 구성된다.At this time, the humectant is composed of 30g of sorbitol, 5g of glycerin, 10g of xylitol and the binder is composed of 0.5g of PEG, 1g of CMC, and 0.3g of xanthan gum.
또한 기타 성분중 약효제는 아미노카프론산 0.1g, 알란토인클로로히드록시알루미늄 0.08g, 안식향산나트륨 0.01g으로 구성되고,In addition, among other ingredients, the drug consists of 0.1 g of aminocaproic acid, 0.08 g of allantoin chlorohydroxyaluminum, and 0.01 g of sodium benzoate,
첨가제는 녹차추출물 11g, 삭카린나트륨 1g, 멘톨 7g, 페퍼민트유 8g, 청색1호(식용색소) 1.07g으로 구성되며,The additive consists of 11g of green tea extract, 1g of saccharin sodium, 7g of menthol, 8g of peppermint oil, 1.07g of blue No. 1 (edible pigment),
정제수는 10g으로 구성된다.Purified water consists of 10 g.
그리고 연마제는 침강탄산칼슘 14.55g, 인산수소칼슘 0.08g으로 구성되며 기포제는 라우릴황산나트륨 0.01g으로 구성된다.And the abrasive is composed of precipitated calcium carbonate 14.55g, calcium hydrogen phosphate 0.08g and the foaming agent is composed of 0.01g sodium lauryl sulfate.
이 밖에 본 발명의 특징에 따라 한방추출물과 프로폴리스가 첨가되는데, 상기 한방추출물에 포함되는 한약재는 천궁 0.06g, 당귀 0.06g, 백지 0.06g, 박하 0.03g, 사철쑥 0.03g, 감초 0.015g, 솔잎 0.015g 및 프로폴리스 0.030g으로 구성되며, 한방추출물 및 프로폴리스 100중량%에 대한 각각 구성성분의 함유량은 천궁 20중량%, 당귀 20중량%, 백지 20중량%, 박하 10중량%, 사철쑥 10중량%, 감초 5중량%, 솔잎 5중량% 프로폴리스 10중량%로 구성된다.In addition, herbal extracts and propolis are added according to the characteristics of the present invention, the herbal medicines included in the herbal extracts are: 0.06g Cheonung, Angelica 0.06g, white paper 0.06g, peppermint 0.03g, cauliflower 0.03g, licorice 0.015g, pine needles It is composed of 0.015g and 0.030g of propolis, the content of each component for 100% by weight of herbal extract and propolis is 20% by weight, Angelica 20% by weight, 20% by weight of white paper, 10% by weight of peppermint, 10% by weight of cedar %, Licorice 5% by weight, pine needles 5% by weight Propolis 10% by weight.
상기 실시예에 기재된 한방추출물과 프로폴리스가 첨가된 치약 (A)와 한방추출물과 프로폴리스가 첨가되지 않은 치약(B) 를 치주염, 치통, 구취, 충치 등의 증상을 호소하거나 진단되는 성인 남녀 20명을 대상으로 10명은 (B) 치약을, 다른 10명은 (A) 치약을 각각 하루 2회씩 15일간 사용하도록 하고, 설문조사에 의하여 효과를 평가한 결과 그 결과는 다음과 같습니다. Adult male and female 20 who have complained or diagnosed symptoms of periodontitis, toothache, bad breath, tooth decay, and the toothpaste (A) and herbal extract and propolis to which the herbal extract and propolis are added described in Examples Ten patients were asked to use (B) toothpaste and 10 others (A) toothpaste twice a day for 15 days, and the results of the survey were evaluated.
표 1 설문조사 결과 (단위: 인수)
구분 별무효과 효과있음 상당한 효과 완치 효과
(B)치약사용 5 2 2 1 10
(A)치약사용 1 1 4 4 10
Table 1 Survey Results (Unit: Acquisition)
division No effect Effective A significant effect Cure effect system
(B) Toothpaste 5 2 2 One 10
(A) Toothpaste One One 4 4 10
본 발명의 한방추출물과 프로폴리스가 첨가된 치약에 대한 탈취효과를 확인하기 위하여 한국원적외선 응용평가연구원에 의뢰한 결과 탈취실험을 실시한 결과, 2시간 만에 91%의 우수한 탈취효과가 있음을 입증하였으며, 시험결과는 다음과 같습니다. In order to confirm the deodorizing effect of the herbal extract of the present invention and the toothpaste added with propolis, as a result of requesting deodorization experiment by Korea Institute of Far Infrared Evaluation, it was proved that there was an excellent deodorizing effect of 91% in 2 hours. The test results are as follows.
표 2 탈취시험결과
시험항목 경과시간(분) Blank농도(ppm) 시료농도(ppm) 탈취율(%)
탈취시험 초기 500 500 -
30 480 80 83
60 470 60 87
90 460 50 89
120 450 40 91
TABLE 2 Deodorization test result
Test Items Elapsed time (minutes) Blank concentration (ppm) Sample concentration (ppm) Deodorization rate (%)
Deodorization test Early 500 500 -
30 480 80 83
60 470 60 87
90 460 50 89
120 450 40 91
또한, 본 발명의 한방추출물과 프로폴리스가 첨가된 치약에 대한 항균효과를 확인하기 위하여 한국원적외선 응용평가연구원에 의뢰한 결과 항균실험을 실시한 결과, 대장균은 24시간 만에 99.9%가 살균되었고, 포도상구균 또한 24시간 만에 99.9%가 살균되는 우수한 항균효과가 있음을 입증하였으며, 시험결과는 다음과 같습니다. In addition, to confirm the antimicrobial effect of the herbal extracts and propolis-added toothpaste of the present invention, as a result of the antimicrobial test conducted by the Korea Institute of Far Infrared Evaluation, E. coli was sterilized 99.9% in 24 hours, staphylococcus Cocci also proved to have an excellent antimicrobial effect, killing 99.9% in 24 hours.
표 3 항균시험결과
시험항목 시료구분 초기농도(CFU/ml) 24시간 후 농도(CFU/ml) 정균감소율(%)
대장균에 의한 항균실험 Blank 1.2×105 1.1×106 -
프로폴리스 치약 <1.0×103 99.9
포도상구균에 의한 항균실험 Blank 1.7×105 2.3×106 -
프로폴리스 치약 <1.0×103 99.9
TABLE 3 Antibacterial Test Results
Test Items Sample classification Initial concentration (CFU / ml) Concentration after 24 hours (CFU / ml) Bacteriostatic reduction rate (%)
Antibacterial Test by Escherichia Coli Blank 1.2 × 10 5 1.1 × 10 6 -
Propolis toothpaste <1.0 × 10 3 99.9
Antibacterial Test by Staphylococcus Blank 1.7 × 10 5 2.3 × 10 6 -
Propolis toothpaste <1.0 × 10 3 99.9
위와 같은 여러 가지의 효능을 가진 각각의 한약재로 구성된 한방추출물과 프로폴리스를 치약에 첨가함으로써 각각의 한약재와 프로폴리스가 서로 상승작용을 하여 치약의 자극을 최소화함은 물론이고, 한약재의 효능 및 사용감을 개선하며, 구강내의 항균 및 염증 예방을 위한 살균력을 향상시켜 치아 및 구강을 청결하게 유지할 수 있을 뿐만 아니라, 충치 및 치주염을 예방하며 치료하는 등의 여러 가지 효과를 얻을 수 있다.By adding herbal extracts and propolis composed of each herbal medicine with various effects as above to toothpaste, each herbal medicine and propolis synergize with each other to minimize stimulation of toothpaste, as well as the efficacy and feel of herbal medicine To improve the antibacterial and inflammation in the oral cavity to improve the sterilization power to keep the teeth and mouth clean, as well as to prevent and treat tooth decay and periodontitis can be obtained.
이상에서 설명한 본 발명은 상술한 실시예에 한정되지 않으며, 본 발명의 기술적 사상을 벗어나지 않는 범위 내에서 치환, 변형 및 변환이 가능하다는 것을 본 발명이 속하는 기술 분야에서, 통상의 지식을 가진 자에게 있어서는 명백할 것이다.The present invention described above is not limited to the above-described embodiment, and those skilled in the art to which the present invention pertains that substitution, modification and conversion are possible without departing from the technical spirit of the present invention. It will be obvious.
본 발명은 통상적인 치약에 한약재인 천궁, 당귀, 백지, 박하, 쑥, 감초, 솔잎이 포함된 한방추출물과 벌꿀에서 추출한 프로폴리스를 첨가함으로써 각각의 한약재 성분의 항균 활성에 의하여 구강 염증을 예방 및 완화시키는 효과가 있으며 장기 보관 시에도 한약재의 안정성 및 치약의 색상과 향의 변화를 억제할 수 있을 뿐만 아니라 살균력을 높여 치아 및 구강을 청결하게 유지할 수 있고 사용감이 우수하여 남녀노소 누구든지 부담 없이 사용할 수 있는 등 여러 가지의 효과가 있다.The present invention is to prevent oral inflammation by the antimicrobial activity of the respective herbal ingredients by adding the herbal extract and herbal extracts containing medicinal herbs, such as Cheonggung, Angelica, white paper, peppermint, mugwort, licorice, pine needles, and honey. It can alleviate the stability of herbal medicines and change the color and scent of toothpaste even during long-term storage, and can increase the disinfection power to keep teeth and oral clean, and the feeling of use is excellent. There are many different effects.

Claims (3)

  1. 치아 겉표면을 세정하기 위한 연마제인 침강탄산칼슘과 인산수소칼슘; 치주질환을 예방하고 염증을 방지하기 위한 약효제인 아미노카프론산과 알란토인클로로히드록시알루미늄; 응고를 막기 위한 습윤제인 솔비톨과 글리세린과 자일리톨; 분말과 액체성분을 결합하기 위한 결합제인 폴리에틸린글리콜(PEG)과 카르복시메틸셀룰로오스(CMC)와 산탄검; 약효성분의 분산 및 침투를 신속하게 하기 위한 기포제인 라우릴황산나트륨; 미생물의 생육을 억제하고 사용감을 좋게하기 위한 첨가제인 안식향산나트륨과 녹차추출물과 삭카린나트륨과 멘톨과 페퍼민트와 청색1호; 정제수로 구성된 치약에 천공, 당귀, 백지, 박하, 쑥, 감초, 솔잎을 포함하는 한방추출물과 프로폴리스가 첨가된 한방추출물과 프로폴리스가 첨가된 치약.Precipitated calcium carbonate and calcium hydrogen phosphate, which are abrasives for cleaning tooth surface; Aminocaproic acid and allantoinchlorohydroxyaluminum, which are agents for preventing periodontal disease and preventing inflammation; Sorbitol, glycerin and xylitol, as humectants to prevent coagulation; Polyethylenglycol (PEG), carboxymethyl cellulose (CMC), and xanthan gum, which are binders for combining powder and liquid components; Sodium lauryl sulfate, which is a foaming agent for prompting dispersion and penetration of the active ingredient; Sodium benzoate, green tea extract, saccharin sodium, menthol, peppermint and blue No. 1, which are additives for inhibiting the growth of microorganisms and improving the feeling of use; Toothpaste composed of purified water, perforated, Angelica, white paper, peppermint, mugwort, licorice, herbal extracts including pine needles, herbal extracts with added propolis and toothpaste added with propolis.
  2. 제 1항에 있어서,The method of claim 1,
    한방추출물과 프로폴리스가 첨가된 치약 100중량%중 한방추출물과 프로폴리스의 함량이 0.2중량% 내지 1.0중량%인 것을 특징으로 하는 한방추출물과 프로폴리스가 첨가된 치약.Herbal extract and toothpaste to which herbal extracts and propolis are added, characterized in that the content of herbal extracts and propolis is 0.2% to 1.0% by weight.
  3. 제 1항에 있어서, The method of claim 1,
    상기 치약에 첨가되는 한방추출물 및 프로폴리스 100중량%에 대하여 천궁 15~25중량%, 당귀 15~25중량%, 백지 15~25중량%, 박하 5~15중량%, 쑥 5~15중량%, 감초 2.5~7.5중량%, 솔잎 2.5~7.5중량% 프로폴리스 5~15중량%로 구성됨을 특징으로 하는 한방추출물과 프로폴리스가 첨가된 치약.15 to 25% by weight, Angelica 15 to 25%, white paper 15 to 25%, peppermint 5 to 15% by weight, mugwort 5 to 15% by weight, based on 100% by weight of the herbal extract and propolis added to the toothpaste Herbal extract and toothpaste added to propolis, characterized in that 2.5 to 7.5% by weight licorice, 2.5 to 7.5% by weight pine needles 5-15% by weight of propolis.
PCT/KR2014/008247 2013-09-09 2014-09-03 Toothpaste containing medicinal herb extract and propolis WO2015034252A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2013-0107835 2013-09-09
KR1020130107835A KR101391545B1 (en) 2013-09-09 2013-09-09 Toothpaste containing medicinal herbs and propolis

Publications (1)

Publication Number Publication Date
WO2015034252A1 true WO2015034252A1 (en) 2015-03-12

Family

ID=50893099

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2014/008247 WO2015034252A1 (en) 2013-09-09 2014-09-03 Toothpaste containing medicinal herb extract and propolis

Country Status (2)

Country Link
KR (1) KR101391545B1 (en)
WO (1) WO2015034252A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105534769A (en) * 2015-12-22 2016-05-04 南昌理工学院 Antibacterial toothpaste containing a baical skullcap root extract product
CN111870545A (en) * 2020-07-08 2020-11-03 广东人为峰健康管理有限公司 Bee venom inflammation-clearing gel toothpaste and preparation method thereof
CN112618415A (en) * 2021-01-20 2021-04-09 深圳市西马龙科技有限公司 Ice-white toothpaste and preparation method thereof
CN112933009A (en) * 2021-02-20 2021-06-11 深圳市西马龙科技有限公司 Efficient antibacterial titanium dioxide nano toothpaste
CN114748401A (en) * 2018-01-10 2022-07-15 班戈卓攀健康产业有限责任公司 Traditional Chinese medicine composition for toothpaste, preparation method of traditional Chinese medicine composition, finished toothpaste and preparation method of finished toothpaste
CN114886829A (en) * 2021-08-10 2022-08-12 李振阳 Toothpaste for treating oral problems and preparation method thereof

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101746723B1 (en) 2014-08-06 2017-06-13 진강중 Dentifrice composition contained pine needle powder
KR101517095B1 (en) * 2014-12-03 2015-05-04 주식회사 제이앤케이 글로벌리소스 Periodontal diseases treatment and prevention composition using the natural extracts
CN105232403A (en) * 2015-11-11 2016-01-13 曹涛 Anti-allergy toothpaste capable of achieving prevention and adjuvant treatment of stomach illness
KR101805417B1 (en) * 2016-04-04 2017-12-07 함양군 Toothpaste composition with wild ginseng extract and bamboo salt and method for production thereof
KR102026659B1 (en) 2017-12-05 2019-09-30 이호규 Antibacterial toothpaste composition containing propolis extraction and manufacturing method thereof
KR102063388B1 (en) 2018-02-01 2020-01-07 동의대학교 산학협력단 Compositions for the prevention or treatment of oral diseases, including extracts of acer tegmentosum maxim and angelica gigas
KR102171798B1 (en) * 2018-02-02 2020-10-29 동의대학교 산학협력단 Composition for treating oral disease and inhibiting halitosis containing natural extracts and preparation method therefor
KR101978742B1 (en) 2018-05-29 2019-05-15 편수헌 Composition for improving sleep comprising natural herbal medicine materials
KR102435912B1 (en) 2020-04-27 2022-08-24 유정수 toothpaste composition in which Meretrix lusoria shell powder and natural extracts is contained
CN112754984A (en) * 2021-03-11 2021-05-07 傅博 Anti-sensitivity liquid toothpaste and preparation method thereof
CN114246823A (en) * 2021-12-13 2022-03-29 江苏罗来雅实业股份有限公司 Ointment for treating oral ulcer and preparation method thereof
KR102458209B1 (en) 2022-04-19 2022-10-24 강삼용 Toothpaste containing crude drugs ingredients and method for producing the same
CN115671003A (en) * 2022-11-23 2023-02-03 上海乐宝日化股份有限公司 Gum repairing toothpaste and preparation method thereof
KR102602562B1 (en) * 2023-02-15 2023-11-17 주식회사 아해바 Toothpaste

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950016696A (en) * 1993-12-29 1995-07-20 최근선 Toothpaste composition containing herbal extract
KR0142442B1 (en) * 1995-03-02 1998-07-15 김형철 Oral compositions
KR20080006109A (en) * 2006-07-11 2008-01-16 방금석 Composition of bubble dentifrice
KR20080013445A (en) * 2006-08-09 2008-02-13 신동목 Composition of toothpaste
KR20100123424A (en) * 2009-05-15 2010-11-24 황철수 Composition of toothpaste for nosmoking with green laver and method of preparing thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950016696A (en) * 1993-12-29 1995-07-20 최근선 Toothpaste composition containing herbal extract
KR0142442B1 (en) * 1995-03-02 1998-07-15 김형철 Oral compositions
KR20080006109A (en) * 2006-07-11 2008-01-16 방금석 Composition of bubble dentifrice
KR20080013445A (en) * 2006-08-09 2008-02-13 신동목 Composition of toothpaste
KR20100123424A (en) * 2009-05-15 2010-11-24 황철수 Composition of toothpaste for nosmoking with green laver and method of preparing thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105534769A (en) * 2015-12-22 2016-05-04 南昌理工学院 Antibacterial toothpaste containing a baical skullcap root extract product
CN114748401A (en) * 2018-01-10 2022-07-15 班戈卓攀健康产业有限责任公司 Traditional Chinese medicine composition for toothpaste, preparation method of traditional Chinese medicine composition, finished toothpaste and preparation method of finished toothpaste
CN111870545A (en) * 2020-07-08 2020-11-03 广东人为峰健康管理有限公司 Bee venom inflammation-clearing gel toothpaste and preparation method thereof
CN112618415A (en) * 2021-01-20 2021-04-09 深圳市西马龙科技有限公司 Ice-white toothpaste and preparation method thereof
CN112933009A (en) * 2021-02-20 2021-06-11 深圳市西马龙科技有限公司 Efficient antibacterial titanium dioxide nano toothpaste
CN114886829A (en) * 2021-08-10 2022-08-12 李振阳 Toothpaste for treating oral problems and preparation method thereof

Also Published As

Publication number Publication date
KR101391545B1 (en) 2014-05-02

Similar Documents

Publication Publication Date Title
WO2015034252A1 (en) Toothpaste containing medicinal herb extract and propolis
US6811769B2 (en) Oral composition, method of making the oral composition and oral hygiene method in japanese and chinese herbal remedy
KR101481371B1 (en) Toothpaste composition containing Curcuma longa L and production method thereof
KR102273358B1 (en) Sanitary absorption pad comprising multi-functional sheet for improving function of anti-bacterial, sterilization and deodorize and irradiating far-infrared rays and negative ions and manufacturing method thereof
KR20180089003A (en) Toothpaste composition comprising natural extracts and preparing method thereof
KR101790034B1 (en) Oral composition for preventing cavity and halitosis
Ambareen et al. Go green-keep the root canal clean
WO2016010284A1 (en) Toothpaste composition containing curcuma longa l., and preparation method therefor
KR102171798B1 (en) Composition for treating oral disease and inhibiting halitosis containing natural extracts and preparation method therefor
CN109248258A (en) Nursing Chinese herbal medicine gargle after a kind of operation on oral cavity
Raj et al. Herbal mouthwash.
CN107913234A (en) A kind of savatier monochasma herb toothpaste and preparation method thereof
KR20030093891A (en) PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME
Beegum et al. Honey the paradisiacal panacea-A Review
KR20040087380A (en) Essential oil composition with excellent antibacterial effect on oral bacteria
CN102440912A (en) Oral cleaning effervescent tablet with functions of diminishing inflammation and arresting bleeding and preparation method thereof
KR101910716B1 (en) Mouthwash containing green tea
KR20170085703A (en) Composition for anti-inflammatory and inhibiting comprising extracts derived from natural materials
KR20130100447A (en) Toothpaste containing medicinal herbs
Abuladze et al. Development of Formulas and Technology of Dental Elixirs with the Use of Plant Resources and Thermal Mineral Waters of Georgia
CN111700825B (en) Oily composition for oral health care, preparation method and application thereof
RU2141817C1 (en) &#34;phytodent&#34; composition for treating mouth cavity and throat diseases
KR20190124073A (en) Composition containing Juniperus rigida siebold and Zucc extracts for preventing the formation of biofilm of microorganism
KR102638091B1 (en) Toothpaste composition with whitening function
KR102502242B1 (en) Toothpaste Composition for Cavum Oris Care and Toothpaste Containing Yellow Ocher

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14842896

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14842896

Country of ref document: EP

Kind code of ref document: A1