KR20030093891A - PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME - Google Patents
PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME Download PDFInfo
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- KR20030093891A KR20030093891A KR1020020031784A KR20020031784A KR20030093891A KR 20030093891 A KR20030093891 A KR 20030093891A KR 1020020031784 A KR1020020031784 A KR 1020020031784A KR 20020031784 A KR20020031784 A KR 20020031784A KR 20030093891 A KR20030093891 A KR 20030093891A
- Authority
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- South Korea
- Prior art keywords
- propolis
- toothpaste
- weight
- tooth decay
- oral
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- 241000241413 Propolis Species 0.000 title claims abstract description 38
- 229940069949 propolis Drugs 0.000 title claims abstract description 38
- 239000000606 toothpaste Substances 0.000 title claims abstract description 22
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 7
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 7
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 6
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 235000010447 xylitol Nutrition 0.000 claims abstract description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 6
- 229960002675 xylitol Drugs 0.000 claims abstract description 6
- 239000000811 xylitol Substances 0.000 claims abstract description 6
- 206010006326 Breath odour Diseases 0.000 claims abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 abstract description 6
- 244000269722 Thea sinensis Species 0.000 abstract description 4
- 235000006468 Thea sinensis Nutrition 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 206010048685 Oral infection Diseases 0.000 abstract description 2
- 208000014151 Stomatognathic disease Diseases 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract description 2
- 230000003115 biocidal effect Effects 0.000 abstract description 2
- 235000020279 black tea Nutrition 0.000 abstract description 2
- 230000001079 digestive effect Effects 0.000 abstract description 2
- 235000009569 green tea Nutrition 0.000 abstract description 2
- 235000020333 oolong tea Nutrition 0.000 abstract description 2
- 230000001766 physiological effect Effects 0.000 abstract description 2
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- 230000002265 prevention Effects 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 241000257303 Hymenoptera Species 0.000 description 5
- 244000005700 microbiome Species 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 150000002206 flavan-3-ols Chemical class 0.000 description 2
- 235000011987 flavanols Nutrition 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 229910052815 sulfur oxide Inorganic materials 0.000 description 2
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 235000018185 Betula X alpestris Nutrition 0.000 description 1
- 235000018212 Betula X uliginosa Nutrition 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical class FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 206010018785 Gingival infections Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000011425 bamboo Chemical class 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002208 flavanones Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- YTAQZPGBTPDBPW-UHFFFAOYSA-N flavonoid group Chemical class O1C(C(C(=O)C2=CC=CC=C12)=O)C1=CC=CC=C1 YTAQZPGBTPDBPW-UHFFFAOYSA-N 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical class S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
이 발명은 천연 항생 물질 및 면역 기능을 활성화시키는 생리 활성 물질로서 여러 다양한 효능, 특히 충치, 치육염 및 구강염 등과 같은 세균성 치과적 질환에 대한 치유 및 예방능이 보고되어 있으며 식품 공전 13-25에 규정된 프로폴리스를 주성분으로 하는 기능성 치약으로서 치약의 조성물 및 그 제조 방법에 관한 것으로서 ,This invention is a natural antibiotic and a physiologically active substance that activates immune function, and has been reported for its various effects, especially for the healing and prevention of bacterial dental diseases such as tooth decay, gingivitis and oralitis, as defined in Food Code 13-25. A functional toothpaste containing propolis as a main component, and relates to a composition of a toothpaste and a method for producing the same.
이 발명의 프로폴리스 치약 조성물은 프로폴리스 0.1 중량%~50 중량%, 녹차, 우롱차 및 홍차의 주성분인 폴리페놀류를 포함하는 추출물 0.1 중량%~50 중량%, 자일리톨 0.1 중량%-50중량%를 첨가제로 사용하였다.Propolis toothpaste composition of the present invention is 0.1% to 50% by weight of propolis, 0.1% to 50% by weight of extract containing polyphenols as the main components of green tea, oolong tea and black tea, 0.1% to 50% by weight of xylitol Used as an additive.
이 프로폴리스 치약은 구강내에서 프로폴리스를 서방출(徐放出)시킴으로써 프로폴리스가 미소량씩 지속적으로 소장내를 통과토록 하여 소화흡수율의 향상을 도모하고, 이로 인한 프로폴리스의 생리활성작용의 최적 발현을 기대할 수 있음과 아울러, 충치 및 구강염 등의 예방 및 치료에 효과가 있는 것으로 보고되어 있는 프로폴리스가 치아 및 구강 내부에 지속적으로 도포되게 되므로 충치의 예방과 치료, 구취의 제거 및, 구강 내부의 세균 증식의 억제 내지 사멸을 통한 구강염의 예방 및 치료를 도모할 수가 있다.This propolis toothpaste is a slow release of propolis in the oral cavity, allowing propolis to continuously pass through the small intestine in small amounts to improve digestive absorption rate, resulting in optimal expression of the physiological activity of propolis. Propolis, which is reported to be effective in the prevention and treatment of tooth decay and oral infection, is continuously applied to the teeth and the oral cavity, thus preventing and treating tooth decay, eliminating bad breath, and It is possible to prevent and treat oral inflammation through inhibition or death of bacterial growth.
Description
본 발명은 프로폴리스(Propolis)를 함유하는 치약 조성물 및 그 제조 방법에 관한 것이며, 더욱 상세하게는, 식물의 표피, 특히 싹이나 꽃 봉오리 등을 외부의 유해한 미생물로부터 보호하기 위하여 식물이 분비하는 수액과 벌의 타액과의 반응에 의해 생성되는 프로폴리스를 주성분으로 하는 치약 조성물 및 그 제조 방법에 관한 것이다.The present invention relates to a toothpaste composition containing Propolis and a method for producing the same, and more particularly, the sap secreted by the plant in order to protect the epidermis of the plant, especially the shoots and buds from the harmful harmful microorganisms A toothpaste composition based on propolis produced by reaction with a saliva of a bee and a method for producing the same.
프로폴리스란 소나무, 전나무, 버드나무, 미류 나무 등과 같은 다양한 종류의 수목 및 초본이 외부의 유해 미생물로부터 자신을 보호하기 위하여 그 표피, 꽃, 봉오리, 새순 등으로부터 분비하는 수액을 벌들이 뒷다리에 붙여 모은 후 자신들의 타액과 혼합하여 타액속의 효소와의 반응에 의해 생성되는 다양한 고분자 중합체들의 복합물에 대한 총칭으로서, 그 주성분은 플라보노이드이다. 플라보노이드는 플라본, 플라보논, 플라보놀, 플라바놀, 플라바논, 플라바놀 및 아이소플라본 등과 같은 안소잔신류 및 당과 결합된 그 배당체, 수백종의 안소샤이아닌 및 당과 결합된 그 배당체, 탄닌류로서의 캬테킨 및 류우코잔신을 포함한다.Propolis is a variety of trees and herbs, such as pine, fir, willow, and rapeseed trees, that bees attach on their hind legs to sap from the skin, flowers, buds, buds, etc. to protect themselves from harmful microorganisms. A generic term for complexes of various polymers produced by the collection and mixing with their saliva and reaction with enzymes in the saliva, the main component of which is flavonoids. Flavonoids are anisozanins such as flavones, flavonones, flavonols, flavanols, flavanones, flavanols and isoflavones, and glycosides associated with sugars, and hundreds of anisoshaineins and glycosides combined with sugars, tannins Catechin and leucozancin.
양봉을 포함하는 자연계에서, 벌들은 프로폴리스를 이용하여 벌집을 냉기나 빗물 등으로부터 보호하기 위하여 사용하고 있음과 아울러, 세균류, 진균류 및 바이러스 등과 같은 각종 미생물이 증식하기에 최적한 습도 및 온도(대략 32~35℃)하에서 수 만 마리가 밀집 생활을 하면서도 병원성 미생물로 인한 집단 발병에 의해 밀집 사회가 사멸하는 일 없이 강한 생명력을 나타내고 있는 것도 다양한 스펙트럼의 미생물군에 대하여 작용할 수 있는 프로폴리스라고 하는 벌 특유의 천연 항생 및 생리 활성 물질이 있기 때문인 것으로 밝혀지고 있다. 벌들은 프로폴리스를 외부와 연결되는 출입구, 빈틈 및 벌집의 내벽 등에 코팅하고 있으나, 특히 여왕벌의 산란 장소 및 유충이 기거하는 장소에 코팅함으로써 알과 유충을 유해한 병원성 미생물이나 주거 환경을 열악하게 만들 수 있는 미생물들로부터 안전하게 보호하고있다.In nature, including beekeepers, bees use propolis to protect their honeycomb from cold and rainwater, and at the best humidity and temperature for the growth of various microorganisms such as bacteria, fungi and viruses (approximately). It is a bee called propolis that can work against diverse spectrum of microorganisms even though tens of thousands live under 32 ~ 35 ℃) and show strong vitality without killing the dense society by the onset of pathogenic microorganisms. It is found to be due to the unique natural antibiotic and bioactive substances. The bees coat propolis on the entrance, gaps and inner walls of the honeycomb, but especially on the spawning site of the queen bee and the larvae's dwelling area, which can make eggs and larvae detrimental to harmful pathogenic microorganisms or residential environments. It is safe from microorganisms.
프로폴리스는 B.C. 300년 훨씬 이전부터 고대 이집트인들에 의하여 방부제로서 미이라의 방부 처리에 효과적으로 사용되었으며, 이러한 방부제로서의 효능은 벌집에 나방이나 작은 들쥐 또는 뱀 등이 들어가 벌들의 공격에 의해 죽은 후, 이들을 벌집 밖으로 운반치 못할 경우 벌들에 의해 코팅 처리된 프로폴리스에 의해 수년간 부패하지 않고 원형이 그대로 보존되고 있는 자연적인 관찰 사실로 부터도 확인될 수 있다. 프로폴리스에 대한 상기한 바와 같은 방부제로서의 효능 외에, 현대 의학에 의한 다양한 논문 및 임상 보고서에서는 프로폴리스의 항암성, 화상 치유능, 습진, 아토피성 피부염 및 무좀 등과 같은 진균류에 의한 피부병 치유능, 탈모 억제능, 생리통 완화 내지 제거 효과, 변비, 피부 미용 및 주름 제거 등과 미용효과, 충치, 치육염 및 구강염 등과 같은 세균성 치과적 질환에 대한 치유 및 예방능이 보고되고 있으며, 이를 근거로 우리나라 보건복지부에서도 최근 식품공전 13-25에 건강보조식품으로 규정해 놓고 있다.Propolis is B.C. Long ago 300 years ago, the ancient Egyptians used it effectively as an antiseptic to embalm mummies.These preservatives were used by moths, small rats, or snakes in the beehive, where they were killed by bees attack and then carried them out of the beehive. Failure to do so can be confirmed by natural observations that the original propolis has been preserved without decay for years by propolis coated by bees. In addition to its efficacy as a preservative as described above for propolis, various papers and clinical reports by modern medicine suggest that propolis' anti-cancer, burn-healing, eczema, atopic dermatitis and athlete's foot are cured by skin fungi, such as athlete's foot, hair loss, etc. It has been reported to suppress and eliminate cramps, remove constipation, skin care and wrinkles, cosmetic effects, and cure and prevent bacterial dental diseases such as tooth decay, gingivitis, and oral infections. It is defined as health supplement in 13-25.
또한, 프로폴리스의 주성분인 플라보노이드에 대해서는, 1969년 러시아 카바르키나 박사의 5.6 배에 달하는 면역력 상승 효과, 1973년 러시아 알렉산드로플의 페니실린 보다 더 강한 살균력 실험 입증 발표, 1991년 일본생화학회의 진통 작용과 항염 효과, 1994년 일본공업전문대학에서의 제암효능 임상실험결과, 기타 전신 세포의 활성화, 호르몬 자극 활동, 비타민 P의 작용에 의한 괴혈병 치료, 고혈압 환자의 혈압강하작용, 생체 호르몬의 균형 유지 등의 효과에 대한 세계 여러 나라의 연구 결과 및 임상시험결과가 보고되어 있다.In addition, for flavonoids, the main component of propolis, in 1969, Dr. Kavarkina's 5.6-fold immunity boosting effect was announced, and in 1973, he demonstrated stronger bactericidal activity than penicillin of Alexandria, Russia. Anti-inflammatory effect, the results of the anti-cancer effect clinical trials at the Japan Institute of Technology in 1994, activation of other systemic cells, hormonal stimulation, treatment of scurvy by the action of vitamin P, blood pressure lowering in hypertensive patients, balance of biological hormones The results of studies and clinical trials in countries around the world have been reported on their effectiveness.
그러나, 프로폴리스는 다양한 종류의 고분자 중합체들로 이루어져 있으므로 소장에서의 소화흡수율이 평균 5% 미만으로서, 정제, 환제, 드링크제, 산제, 캡슐제, 분말제 등과 같은 경구 투여용으로 제제화할 경우 흡수 기관인 소장벽을 비교적 단시간내에 벌크(bulk)량으로 통과하게 되므로 흡수율이 매우 낮아서 투여량에 비해 기대치 이하의 프로폴리스 투여 효과를 나타내게 되는 문제점이 있었다.However, because propolis is composed of various polymers, the digestive absorption rate in the small intestine is less than 5% on average, and it is an absorbent organ when formulated for oral administration such as tablets, pills, drinks, powders, capsules, and powders. Since the intestinal wall passes through the bulk in a relatively short time, there is a problem in that the absorption rate is very low and thus the propolis administration effect is lower than expected compared to the dosage.
또한 정기적인 치아 관리를 한다 하더라도 충치나 구강염의 발생 자체를 효과적으로 억제하기 곤란한 것이 현실이다.In addition, even in the case of regular dental care it is difficult to effectively suppress the occurrence of dental caries or mouth infection itself.
따라서, 본 발명의 첫 번째 목적은, 프로폴리스가 구강내에서 서방출(徐放出)됨으로써 상기한 프로폴리스가 미소량씩 흡수토록하여 흡수율을 높이고, 이로인하여 프로폴리스의 생리활성작용을 최적하게 발현시킬 수 있는 프로폴리스 치약 조성물을 제공하기 위한 것이다.Therefore, the first object of the present invention is that the propolis is released slowly in the oral cavity (徐 放出) so that the above-mentioned propolis is absorbed by a small amount to increase the absorption rate, thereby to optimally express the physiological activity of the propolis. It is to provide a propolis toothpaste composition.
본 발명자는 지금까지 기존의 치약성분에 불소나 소금 또는 죽염등을 혼합하여 기능성치약이 실용화되고 있는데 반하여, 향균,항염작용이 강한 프로폴리스등을 첨가한 치약을 이용함으로써 치아에 도포되어 있거나 치간에 끼어 있는 유기물질을 없애고 더 나아가 향균작용으로 말미암아 구취를 제거함과 동시에 치아보호는 물론 잇몸의 노화억제까지 할 수 있는 과정에서 원래의 프로폴리스는 파라핀에서 유리된 흡착성이 매우 강한 고분자를 가지고 있는 물질로서 본 발명에서 사용되는 수용성의 프로폴리스도 분자구조가 같아 살갓 표면에 잘 도포되기 때문에 일발치약에다 수용성의 프로폴리스를 첨가하여 제조하는 q아법을 사용하였고, 이때의 프로폴리스의 특징은 항산화물질인 저분자의 폴리페놀과 충치의 원인균인 뮤탄스균의 번식을 억제하는 첨가물등을 혼합사용토록 발명함으로써, 입냄새 제r, 치석제가, 잇몸의 항산화작용, 향균작용, 항염작용을 함으로써항상 청결하고 악취가 없는 구강의 위생관리가 이루어지는 방법으로서 본 발명을 창안하게 된 것이다.The present inventors have been used to the functional toothpaste by mixing fluorine, salt, or bamboo salt with the existing toothpaste components, while the toothpaste is applied to the teeth by using a toothpaste with antibacterial and anti-inflammatory properties. In the process of eliminating organic matters and further eliminating bad breath by antibacterial action, while protecting the teeth and inhibiting aging of the gums, the original propolis has a very strong adsorbent polymer released from paraffin. Since the water-soluble propolis used in the present invention has the same molecular structure and is well coated on the surface of the skin, a method of preparing by adding a water-soluble propolis to a single toothpaste is used, and the characteristic of the propolis is the low molecular weight of the propolis. Suppress the propagation of mutans bacteria which is the causative agent of polyphenols and tooth decay By inventing a mixture of additives and the like, the present invention was developed as a method of hygienic management of oral hygiene and cleanliness, which is always performed by anti-oxidant, antibacterial and anti-inflammatory action of gums and tartar. .
다음으로 바람직한 실시예를들어 구체적으로 본 발명을 설명한다.Next, the present invention will be described in detail with reference to preferred embodiments.
실시예1Example 1
물이나 알콜로 추출한 프로폴리스 수용성원액을 취한다.Take an aqueous solution of propolis extracted with water or alcohol.
실시예2Example 2
황산화물(SOD)중 녹차나 우롱차, 홍차의 주성분인 폴리페놀을취한다.Take the polyphenol which is the main ingredient of green tea, oolong tea and black tea among sulfur oxides (SOD).
실시예3Example 3
자작나무수액가공물인 자일리톨을 취한다.Take xylitol, a birch sap.
실시예4Example 4
실시예1에서 얻은 프로폴리스수용액원액을 치약중량비 0.1%내지 50%에 실시2에서 얻은 폴리페놀원액을 0.1% 내지 50%에 실시예3에서 얻은 자일리톨분말을 0.2%내지 50%를 잘 섞은다음 적당한 온도에서 적당시간 교반한다.Mix the propolis aqueous solution obtained in Example 1 with 0.1% to 50% of the toothpaste weight ratio in 0.1% to 50% of the polyphenol solution obtained in Example 2, and mix 0.2% to 50% of the xylitol powder obtained in Example 3 well. Stir at a moderate temperature.
실시예5Example 5
실시4에서 얻은 건조물에 일반치약의 주원료 및 부원료와 기타 향료, 소금, PH조절제등을 넣어 겔상태의 치약을 제조한다.Gel toothpaste is prepared by adding the main and subsidiary ingredients of general toothpaste, other fragrances, salts, and PH regulators to the dried product obtained in Example 4.
실시예의 종합Synthesis of Examples
상기 실시예에서 얻어진 치약 즉, 프로폴리스에 폴리페놀과 자일리톨이 함유된 본 발명치약은 폴리페놀에 의한 표피지방질의 제거,고분자 프로폴리스 및 자일리톨이 장시간 동안 치아와 잇몸 혀에 머무르고 있기 때문에 각종세균의 사멸 및 번식억제로 인하여 항상 청결하고, 악취가 없으며, 뽀득뽀득한 치아가 유지되어 위생적인 구강청결이 이루어진다.The toothpaste obtained in the above example, that is, the present invention containing the polyphenol and xylitol in the propolis is used to remove the epidermal fat by the polyphenol, the polymer propolis and the xylitol stay on the teeth and gum tongue for a long time. Hygienic oral cleansing is achieved by maintaining clean, odorless and crisp teeth at all times due to suppression of death and reproduction.
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KR20200071360A (en) | 2018-12-11 | 2020-06-19 | 주식회사 엘리바이오 | Toothpaste Composition Comprising Rosa Canina Extract |
KR20220099175A (en) | 2021-01-05 | 2022-07-13 | 주식회사 케이보은제약 | Oral composition comprising herbal complex |
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KR20010111819A (en) * | 2000-06-13 | 2001-12-20 | 서진호 | The oral cleaning medicine containing the propolis |
KR20030000275A (en) * | 2001-06-22 | 2003-01-06 | 금호덴탈제약 주식회사 | A process of toothpaste with greentea extract |
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KR100719306B1 (en) | 2004-11-04 | 2007-05-17 | 김희성 | Mouthwash Composition Containing Water Soluble Propolis Extract |
WO2018062605A1 (en) * | 2016-09-27 | 2018-04-05 | 셀포원 | Toothpaste composition containing galenical extract |
KR20190066201A (en) | 2017-12-05 | 2019-06-13 | 이호규 | Antibacterial toothpaste composition containing propolis extraction and manufacturing method thereof |
KR20200071360A (en) | 2018-12-11 | 2020-06-19 | 주식회사 엘리바이오 | Toothpaste Composition Comprising Rosa Canina Extract |
KR20220099175A (en) | 2021-01-05 | 2022-07-13 | 주식회사 케이보은제약 | Oral composition comprising herbal complex |
KR20240011429A (en) | 2022-07-19 | 2024-01-26 | 셀포원(주) | Oral care toothpaste composition containing herbal extract |
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