KR20010027080A - Oral cavity purifier containing water-soluble chitosan - Google Patents

Oral cavity purifier containing water-soluble chitosan Download PDF

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KR20010027080A
KR20010027080A KR1019990038657A KR19990038657A KR20010027080A KR 20010027080 A KR20010027080 A KR 20010027080A KR 1019990038657 A KR1019990038657 A KR 1019990038657A KR 19990038657 A KR19990038657 A KR 19990038657A KR 20010027080 A KR20010027080 A KR 20010027080A
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chitosan
water
weight
soluble chitosan
molecular weight
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KR1019990038657A
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KR100347342B1 (en
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서상봉
유향자
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주식회사 자광
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

PURPOSE: A mouth detergent containing water-soluble chitosan is provided, which controls activity of microorganisms in mouth by preventing formation of sugar protein with the microorganisms, so prevents decayed tooth and periodontitis by removing mouth odor and tartar on the teeth. CONSTITUTION: The mouth detergent containing water-soluble chitosan is comprised of water-soluble chitosan(average molecular weight is 200,000-250,000) 5-90wt., sedimentation calcium carbonate(which shows whitening effect by removing tartar on the teeth) 5-70wt., xylitol 1-20wt. and calcium mono hydrogen phosphate(which is coated on the teeth enamel to show prevention and treatment effect) 0.1-10wt. The chitosan is prepared by: ultrasonic and enzyme-treating the various molecular weight of chitosan compound; adding water to get chitosan solution; separating and refining using a multi-stage separating-membrane process to get the water-soluble chitosan.

Description

수용성 키토산을 함유한 구강 청정제{Oral cavity purifier containing water-soluble chitosan}Oral cavity purifier containing water-soluble chitosan

본 발명은 수용성 키토산을 함유한 구강 청정제에 관한 것으로, 좀 더 상세하게는 수평균분자량이 20∼25만인 수용성 키토산을 함유한 구강 청정제에 관한 것이다.The present invention relates to an oral cleanser containing water-soluble chitosan, and more particularly, to an oral cleanser containing water-soluble chitosan having a number average molecular weight of 20 to 250,000.

치아에서 발생하는 질환으로는 충치와 치주 질환이 있는데, 이는 스트렙토코커스 뮤탄스(Streptococcus mutans), 락토바실러스 카제이(Lactobacillus casei), 대장균(E. coli.) 등과 같은 구강내 미생물에 의한 것으로, 상기 미생물이 당류를 분해하여 불용성 글루칸을 만들고, 이들이 각종 균체와 함께 치아 표면에 부착, 치석을 형성한다. 이들 치석에 부착된 미생물이 당을 분해하여 생성된 산이 치아 표면의 에타멜층을 용해시켜 충치를 발생시키고, 균의 사체에 의해 치욕이 용해되어 치주 질환이 발생된다.Diseases that occur in teeth include caries and periodontal disease, which are caused by oral microorganisms such as Streptococcus mutans, Lactobacillus casei, E. coli, and the like. Microorganisms break down sugars to form insoluble glucans, which together with various cells adhere to the tooth surface and form tartar. Acids generated by microorganisms attached to these tartars dissolve sugars to dissolve the etamel layer on the surface of the tooth to cause tooth decay.

이러한 구강내 미생물의 활성을 제어시키기 위해, 양이온 활성을 갖는 천연 생체 고분자 재료로서, 강한 항균작용, 항산화작용, 세포활성화 작용, 출혈방지 기능이 있는 키토산 또는 키틴을 함유한 조성물의 연구가 활발히 진행되고 있다.In order to control the activity of the microorganisms in the oral cavity, as a natural biopolymer material having a cationic activity, research into a composition containing chitosan or chitin with strong antibacterial activity, antioxidant activity, cell activation action and anti-bleeding function is actively conducted. have.

그 한 예로, 한국 특허출원 제97-16800호에서는 상기 미생물 중 스트렙토코커스 뮤탄스의 구강내 활성을 감소시킬 수 있는 조성물을 기술하고 있다. 그러나, 상기 조성물은 상기 미생물의 활성을 제어하는데는 효과가 있으나, 키틴 수용액을 포함하여 10가지 이상의 성분을 배합한 것으로, 제조가 복잡하고 제조 비용이 비싸다. 또한, 분자량에 따라 각각 독특한 활성을 갖는 키토산의 가공전 물질인 키틴을 사용하였다는 점에서 효과면에서 한계가 있다.As an example, Korean Patent Application No. 97-16800 describes a composition that can reduce the oral activity of Streptococcus mutans in the microorganism. However, the composition is effective in controlling the activity of the microorganism, but is formulated with 10 or more components, including chitin aqueous solution, the production is complicated and expensive to manufacture. In addition, there is a limit in effect in that chitin, which is a material before processing chitosan, each having a unique activity depending on molecular weight, is used.

이에, 본 발명자는 상기 문제점을 해결하기 위하여 광범위한 연구를 수행한 결과, 키토산 성분 중 수평균분자량이 20∼25만인 수용성 키토산 성분이 구강내 미생물의 활성 제어에 효과가 있음을 발견하였고, 본 발명은 이에 기초하여 완성되었다.Accordingly, the present inventors conducted extensive research to solve the above problems, and found that the water-soluble chitosan component having a number average molecular weight of 20 to 250,000 among the chitosan components is effective in controlling the activity of oral microorganisms. Completed on this basis.

따라서, 본 발명은 치아보호 및 구강 질병 예방을 위해 수평균분자량이 20∼25만인 수용성 고분자 키토산을 함유한 구강 청정제를 제공하는데 그 목적이 있다.Accordingly, an object of the present invention is to provide an oral cleaning agent containing a water-soluble polymer chitosan having a number average molecular weight of 20 to 250,000 for tooth protection and oral disease prevention.

상기 목적을 달성하기 위한 본 발명의 구강 청정제는 수평균분자량이 20∼25만인 수용성 키토산 5∼90중량, 침강 탄산칼슘 5∼70중량, 자일리톨 1∼20중량및 인산일수소칼슘 0.1∼10중량을 포함한다.In order to achieve the above object, the oral cleanser of the present invention may contain 5 to 90 weight of water-soluble chitosan, 5 to 70 weight of precipitated calcium carbonate, 1 to 20 weight of xylitol, and 0.1 to 10 weight of calcium dihydrogen phosphate. Include.

이하 본 발명을 좀 더 구체적으로 살펴보면 다음과 같다.Looking at the present invention in more detail as follows.

본 발명에 따른 구강 청정제의 주성분으로써 천연 키토산 중 평균분자량이 20∼25만인 수용성 키토산을 사용하였다. 본 발명에서는 분자량이 20∼25만인 수용성 키토산의 순도 및 특성에 따른 유효 적절한 배합을 통하여, 적절한 구강 재료로서, 치약, 구강 치료, 보강재, 치석제거용 치실, 봉합사, 치아보호 등에 이용을 도모하였다. 천연 키토산은 평균분자량이 1000부터 100만 이상까지 다양한 분자량 분포를 갖는데, 이러한 넓은 분자량 분포중에서 평균분자량이 20∼25만인 것이 치아와 치주의 당단백질, 치면세균을 억제하여 치주병과 치석을 제거하는데 바람직하였다. 즉, 평균분자량이 20만 미만인 경우는 치면세균을 억제하는 효과가 미비하고, 25만을 초과하면 입안에 늘러 붙거나 녹는 시간이 약 4분정도 소요되어 일반적인 칫솔질의 시간인 2∼3분안에 사용하기에는 불리한 단점이 있었다.As a main component of the mouthwash according to the present invention, a water-soluble chitosan having an average molecular weight of 20 to 250,000 in natural chitosan was used. In the present invention, through effective combination according to the purity and properties of the water-soluble chitosan having a molecular weight of 20 to 250,000, it is intended to use as a suitable oral material, toothpaste, oral treatment, reinforcement, floss for removing tartar, suture, dental care and the like. Natural chitosan has a molecular weight distribution ranging from 10 to over 1 million in average molecular weight. Among these broad molecular weight distributions, an average molecular weight of 20 to 250,000 is preferred for removing periodontal disease and calculus by inhibiting dental proteins and periodontal bacteria. It was. In other words, if the average molecular weight is less than 200,000, the effect of inhibiting the dental plaque is inadequate, and if it exceeds 250,000, it takes about 4 minutes to stick or melt in the mouth, and it is not suitable for use in 2 to 3 minutes of general brushing time. There were disadvantages.

본 발명에 사용한 키토산은 다양한 분자량의 키토산 혼합물을 초음파 및효소처리한 후, 수용액을 제조하여 다단계 분리막 공정으로 분리 정제하여 사용하였다. 이렇게 분리된 키토산은 수용성이며, 분자량별 이용의 가치는 한국 특허출원 제97-20951호에 기술되어 있다.Chitosan used in the present invention was subjected to ultrasonic and enzymatic treatment of chitosan mixtures of various molecular weight, to prepare an aqueous solution was used by separation and purification in a multi-stage membrane process. The chitosan thus separated is water-soluble, and the value of use by molecular weight is described in Korean Patent Application No. 97-20951.

전술한 바와 같이, 키토산은 양이온 활성을 갖는 천연생체 고분자 재료로서, 강한 항균작용, 항산화 작용, 세포활성화 작용, 출혈방지, 치석제거, 충치, 풍치 예방에 효과가 있는 것으로 알려져 있다. 특히, 키토산이 수용성화 됨에 따라 산업에의 이용의 폭이 증대되었으며, 각 분야에서, 상기 수용성 키토산을 다른 물질과 효율적으로 배합하여 유용하게 활용될 가치가 무한하다 하겠다. 본 발명에 따르면, 키토산의 수평균분자량이 25만 이하는 식물용으로 바람직하며, 수평균분자량이 20∼30만 대는 표준시약으로 농산, 축산, 수산, 생활용품, 의약재료, 의약품 등으로 바람직하고, 수평균분자량이 30∼40만은 기능성 식품, 의학품, 고기능의 항균력과 점도 등을 필요로 하는 소재 등의 특수목적에 사용되는 제품에 바람직하며, 30∼100만 이상은 생체 재료, 항암제 등으로 바람직하다.As described above, chitosan is a natural biomaterial having a cationic activity, and is known to be effective in preventing strong antibacterial activity, antioxidant activity, cell activation, bleeding prevention, tartar removal, tooth decay, and flavor. In particular, as the chitosan is water-soluble, the range of use in the industry has increased, and in each field, it is infinitely useful to effectively use the water-soluble chitosan in combination with other materials. According to the present invention, the chitosan has a number average molecular weight of 250,000 or less is preferred for plants, and the number average molecular weight of 20-300,000 units is a standard reagent for agricultural, livestock, fisheries, household goods, pharmaceutical materials, pharmaceuticals, etc. The number average molecular weight of 30-400,000 is preferable for products used for special purposes such as functional foods, medical products, and materials that require high antibacterial activity and viscosity. desirable.

본 발명에서 사용된 수용성 키토산의 함량은 5∼90중량이며, 침강 탄산칼슘은 5∼70중량, 자일리톨은 1∼20중량이고, 인산일수소칼슘은 0.1∼10중량이며, 이를 적절해 배합하여 사용하였다. 즉, 상기 수용성 키토산의 함량이 5중량미만이면 효과가 떨어지고, 90중량를 초과하면 미각이 텁텁하고 아리다. 또한, 상기 침강 탄산칼슘의 함량이 5중량미만이면 미백효과가 떨어지며, 70중량를 초과하면 텁텁하고 치아 마모가 발생하는 문제가 있다. 아울러, 또한, 상기 자일리톨 함량이 1중량미만이면 입안 느낌이 깔깔하고, 20중량를 초과하면 입안에 단맛이 강하며, 상기 인산일수소칼슘의 함량이 0.1중량미만이면 첨가효과가 미비하고, 10중량를 초과하면 겔 형성, 치아 법랑질의 코팅에 불리한 경향이 있다.The content of water-soluble chitosan used in the present invention is 5 to 90 weights, 5 to 70 weights of precipitated calcium carbonate, 1 to 20 weights of xylitol, and 0.1 to 10 weights of calcium dihydrogen phosphate. It was. That is, if the content of the water-soluble chitosan is less than 5 wt. In addition, when the content of the precipitated calcium carbonate is less than 5 weight, the whitening effect is lowered, and when the content of the precipitated calcium carbonate exceeds 70 weight, there is a problem that the tooth wear occurs. In addition, if the xylitol content is less than 1 weight, the mouth feels dark, and if it exceeds 20 weights, the sweet taste is strong in the mouth, and if the content of calcium monohydrogen phosphate is less than 0.1 weight, the addition effect is insufficient, and exceeds 10 weights. Lower surface tends to be disadvantageous for gel formation and coating of tooth enamel.

이와 같이, 키토산은 균과 당 단백질의 형성을 방지하고, 침강 탄산칼슘은 치석제거에 의한 미백효과에 유리하며, 자일리톨은 균이 이용할 수 없는 당의 형태로 입안 느낌을 좋게한다. 또한, 인산일수소칼슘은 치아 법랑질에 코팅되어 이들 성분과 키토산이 갖는 특징이 어울려 예방 및 치료효과가 탁월하게 나타난다.As such, chitosan prevents the formation of bacteria and sugar proteins, precipitated calcium carbonate is advantageous for the whitening effect by tartar removal, and xylitol improves the mouth feeling in the form of sugars that bacteria cannot use. In addition, calcium dihydrogen phosphate is coated on the tooth enamel so that the characteristics of these components and chitosan are well matched, and the prevention and treatment effect is excellent.

본 발명에 따른 구강 청정제 조성물은 통상의 방법으로 부형제들을 조절하여 분말형태, 또는 겔 또는 액상 형태로 사용가능하다. 또한, 상기 성분외에 필요에 따라 비타민류와 같은 기능성 성분들을 기타 첨가제로 더욱 포함할 수 있다.The mouthwash composition according to the present invention can be used in powder form, gel or liquid form by adjusting the excipients in a conventional manner. In addition to the above components, functional ingredients such as vitamins may be further included as other additives as necessary.

이하, 실시예를 통하여 본 발명을 좀 더 구체적으로 살펴보지만 하기 실시예에 본 발명의 범주가 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples, but the scope of the present invention is not limited to the following Examples.

실시예 1Example 1

평균분자량이 20만인 분획 수용성 키토산 5중량, 침강 탄산칼슘 70중량, 자일리톨 20중량및 인산일수소칼슘 5중량를 혼합하여 스트렙토코커스 뮤탄스, 락토바실러스 카제이, 및 대장균을 각각 배양한 액을 굳힌 멸균배지 7개(총 21개)에 1ml를 도포하고, 각기 다른 구강청정제 6개를 대조구로 하여 비교 표시하였다. 실험은 두가지 방법으로 하나는 디스크 페이퍼(disk paper)에 구강청정제를 묻혀 건조시킨 후, 생육 저해환의 크기변화로 항균력을 측정하였고, 다른 방법은 상기와 같이 구강청정제 액을 도포하여 생성되는 콜로니의 수를 세어 하기 표 1에 나타내었다.Sterilized medium in which cultured Streptococcus mutans, Lactobacillus casei, and Escherichia coli were cultured by mixing 5 parts by weight of water-soluble chitosan having an average molecular weight of 200,000, 70 weight of precipitated calcium carbonate, 20 weight of xylitol, and 5 weight of calcium dihydrogen phosphate. 1 ml was applied to 7 (21 total), and 6 different mouthwashes were compared and displayed as a control. The experiment was performed by two methods, one of which was coated with an oral cleanser on disk paper and dried, and then the antimicrobial activity was measured by the size change of growth inhibiting ring. The other method was the number of colonies produced by applying the oral cleanser solution as described above. The counts are shown in Table 1 below.

실시예 2Example 2

평균분자량이 20만인 분획 수용성 키토산 10중량, 침강 탄산칼슘 70중량, 자일리톨 15중량및 인산일수소칼슘 5중량를 혼합하여 사용한 것을 제외하고는 실시예 1과 같이 실시하였다.It carried out like Example 1 except having used the mixture of 10 weight part fraction water-soluble chitosan, 70 weight settled calcium carbonate, 15 weight xylitol, and 5 weight calcium dihydrogen phosphate which have an average molecular weight of 200,000.

실시예 3Example 3

평균분자량이 20만인 분획 수용성 키토산 30중량, 침강 탄산칼슘 50중량, 자일리톨 15중량및 인산일수소칼슘 5중량를 혼합하여 사용한 것을 제외하고는 실시예 1과 같이 실시하였다.It carried out similarly to Example 1 except having used the mixture of 30 weight part fraction water-soluble chitosan, 50 weight settle calcium carbonate, 15 weight xylitol, and 5 weight calcium dihydrogen phosphate which have an average molecular weight of 200,000.

실시예 4Example 4

평균분자량이 20만인 분획 수용성 키토산 50중량, 침강 탄산칼슘 35중량, 자일리톨 10중량및 인산일수소칼슘 5중량를 배합하여 사용한 것을 제왜하고는 실시예 1과 같이 실시하였다.It carried out as in Example 1 except using 50 weight part fraction water-soluble chitosan, 35 weight precipitated calcium carbonate, 10 weight xylitol, and 5 weight calcium dihydrogen phosphate which average molecular weight was used.

실시예 5Example 5

분자량이 20만인 분획 수용성 키토산 70중량, 침강 탄산칼슘 20중량, 자일리톨 8중량및 인산일수소칼슘 2중량를 사용한 것을 제외하고는 실시예 1과 같이 실시하였다.The procedure was carried out as in Example 1, except that 70 parts by weight of fractional water-soluble chitosan, 20 parts by weight of precipitated calcium carbonate, 8 parts by weight of xylitol, and 2 parts by weight of calcium dihydrogen phosphate were used.

실시예 6Example 6

분자량이 20만인 분획 수용성 키토산 90중량, 침강 탄산칼슘 20중량, 자일리톨 8중량및 인산일수소칼슘 2중량를 사용한 것을 제외하고는 실시예 1과 같이 실시하였다.The procedure was carried out as in Example 1, except that 90 parts by weight of water-soluble chitosan having a molecular weight of 200,000, 20 parts by weight of precipitated calcium carbonate, 8 parts by weight of xylitol, and 2 parts by weight of calcium dihydrogen phosphate were used.

균류Fungus 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 실시예 6Example 6 스트렙토코커스 뮤탄스Streptococcus mutans 1010 88 7.37.3 6.46.4 55 44 락토바실러스 카제이Lactobacillus casei 1717 1414 1212 99 88 77 대장균(E. coil.)E. coil. 66 33 22 22 1One 00

한편, 상기 실시예 1 내지 6의 구강 청정제를 이용하여 미백효과, 치석제거 및 입안느낌을 50명을 대상으로 3회 패널 테스트한 결과를 하기 표 2에 기재하였고, 그 결과 실시예 2 및 3의 경우가 가장 우수하였다.On the other hand, using the oral cleaning agent of Examples 1 to 6, the results of three panel tests for 50 people whitening effect, tartar removal and mouth feel are described in Table 2 below, the results of Examples 2 and 3 The case was the best.

예Yes 실시예 1Example 1 실시예 2Example 2 실시예 3Example 3 실시예 4Example 4 실시예 5Example 5 실시예 6Example 6 미백효과Whitening effect 있다(88)There is (88) 있다(96)There is (96) 있다(96)There is (96) 있다(98)There is (98) 있다(100)There is (100) 있다(98)There is (98) 치석제거Tartar removal 있다(84)There is (84) 있다(98)There is (98) 있다(98)There is (98) 있다(98)There is (98) 있다(98)There is (98) 있다(98)There is (98) 입안느낌Mouth feeling 좋다(86)모름(10)별로(4)Good (86) Unknown (10) Stars (4) 좋다(96)모름(2)무답(2)Good (96) I don't know (2) No answer (2) 좋다(94)모름(2)별로(4)Good (94) I don't know (2) 좋다(90)모름(4)별로(6)Good (90) Unknown (4) Stars (6) 좋다(86)모름(4)별로(10)Good (86) Unknown (4) Stars (10) 좋다(82)모름(4)별로(16)Good (82) Unknown (4) Stars (16)

이상에서 살펴본 바와 같이, 본 발명의 구강 청정 조성물은 수용성 키토산, 침강 탄산칼슘, 자일리톨, 및 인산일수소칼슘을 적절히 배합함으로써, 간단하게 제조 가능하며, 구강내 미생물의 활성 제어에 효과가 있어 구강 냄새 제거 및 치석 제거로 인한 충치 및 풍치 예방에 효과가 있다.As described above, the oral clean composition of the present invention can be easily prepared by appropriately combining water-soluble chitosan, precipitated calcium carbonate, xylitol, and calcium hydrogen hydrogen phosphate, and is effective in controlling the activity of microorganisms in the oral cavity. It is effective in preventing tooth decay and flavor caused by removal and removal of tartar.

Claims (2)

수평균분자량이 20∼25만인 수용성 키토산 5∼90중량, 침강 탄산칼슘 5∼70중량, 자일리톨 1∼20중량및 인산일수소칼슘 0.1∼10중량을 포함하는 것을 특징으로 하는 수용성 키토산을 함유한 구강 청정제.Oral water-soluble chitosan containing 5 to 90 weight of water-soluble chitosan having a number average molecular weight of 20 to 250,000, 5 to 70 weight of precipitated calcium carbonate, 1 to 20 weight of xylitol and 0.1 to 10 weight of calcium dihydrogen phosphate Cleaning agent. 제1항에 있어서, 상기 구강 청정제의 형태가 분말, 겔 또는 액상임을 특징으로 하는 수용성 키토산을 함유한 구강 청정제.The oral cleanser containing water-soluble chitosan according to claim 1, wherein the oral cleanser is in powder, gel or liquid form.
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Cited By (7)

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KR20020028765A (en) * 2001-07-25 2002-04-17 송병식 Tooth paste composition against paradental desease comprising chitosan and oriental herb medicine extracts
KR20030000275A (en) * 2001-06-22 2003-01-06 금호덴탈제약 주식회사 A process of toothpaste with greentea extract
KR20030093891A (en) * 2002-06-05 2003-12-11 김희성 PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME
WO2004010962A1 (en) * 2002-07-31 2004-02-05 Bon-Gil Koo Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals
KR20040019145A (en) * 2002-08-26 2004-03-05 주식회사 이코바이오 Natural Mouthwash Formulation
KR100471715B1 (en) * 2002-07-12 2005-03-08 주식회사 서흥캅셀 Composition or preparation for removing oral smell
KR20050075162A (en) * 2004-01-15 2005-07-20 주식회사 자광 Functional beverage composition containing water-soluble chitosan

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KR102181718B1 (en) 2018-12-17 2020-11-23 진태원 Abrasive-free foamable solid mouthwash
KR102588162B1 (en) 2023-03-17 2023-10-12 배광학 Oral preparations containing water-soluble chitosan and manufacturing method thereof

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US4512968A (en) * 1982-11-30 1985-04-23 Lion Corporation Oral compositions

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030000275A (en) * 2001-06-22 2003-01-06 금호덴탈제약 주식회사 A process of toothpaste with greentea extract
KR20020028765A (en) * 2001-07-25 2002-04-17 송병식 Tooth paste composition against paradental desease comprising chitosan and oriental herb medicine extracts
KR20030093891A (en) * 2002-06-05 2003-12-11 김희성 PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME
KR100471715B1 (en) * 2002-07-12 2005-03-08 주식회사 서흥캅셀 Composition or preparation for removing oral smell
WO2004010962A1 (en) * 2002-07-31 2004-02-05 Bon-Gil Koo Liquid composition for protecting oral cavities and teeth of pet animals and use thereof in plaything for pet animals
KR20040019145A (en) * 2002-08-26 2004-03-05 주식회사 이코바이오 Natural Mouthwash Formulation
KR20050075162A (en) * 2004-01-15 2005-07-20 주식회사 자광 Functional beverage composition containing water-soluble chitosan

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