KR100807842B1 - Anti-fungal composition for deodorization - Google Patents

Abstract

The present invention provides an antimicrobial active substance, such as the extract of the lint, propolis and zinc pyrithione; And a surfactant as a carrier and a cleaning agent.

According to the antimicrobial composition according to the present invention, by including the natural extracts, such as jouleum extract, propolis and zinc pyrithione, excellent antibacterial action against athlete's foot fungi, etc., antibacterial action against athlete's foot fungi, such as foot odor suppression, and also inhibits dandruff, etc. It is possible.

Antibacterial, Athlete's Foot, Jelly Extract

Description

Antimicrobial composition for deodorization {Anti-fungal composition for deodorization}

1 is a photograph of a foot infected with athlete's foot before using the antimicrobial composition according to Example 6 of the present invention.

Figure 2 is a photograph of the foot of the fifth day after using the antimicrobial composition according to Example 6 of the present invention.

Figure 3 is a photograph of the foot of day 12 after using the antimicrobial composition according to Example 6 of the present invention.

The present invention relates to an antimicrobial composition for inhibiting athlete's foot, etc. More specifically, the antimicrobial composition for inhibiting athlete's foot, dandruff, foot odor, etc., including antibacterial active substances such as extracts of joules and treatment of athlete's foot, dandruff, etc. using the same It is about a method.

In general, athlete's foot is a skin disease caused by a fungus (called dermatophyte) known as ringworm, and its causative agent is trichophyton rubrum and trichophyton mentagroite (T. mentagrophyte) and Epidermophyton floccosum.

Among them, tricophyton mentagroite grows through hyphae, and, like other dermaiteites, is known to have the highest biological activity at the tip of the hyphae. Cell wall components synthesized in this part are moved through the vesicles of the tip and grow. Due to this cause, athlete's foot penetrates into the stratum corneum of the skin and causes cracking, odor and itching.

As a method for preventing and treating such athlete's foot, folk remedies such as using vinegar are known, but a stable amount of use and a method of use are not determined.

In addition, it is also possible to use a therapeutic agent containing a compound of the steroid system, but these compounds are known to have a disadvantage of resistance to long-term use.

On the other hand, natural extracts have relatively low side effects, such as resistance compared to conventional synthetic compounds and easy to obtain, has been used in various fields recently.

In particular, in the field of antimicrobial agents, interest in antimicrobial substances obtained from natural products is increasing. For example, propolis collects sap secreted by trees to protect themselves from external microorganisms, and then collects the bees on their hairs and mixes them with their saliva to produce a complex of polymers produced by the sap reacting with the bee's saliva. Is a generic term for.

Propolis is B.C. More than 300 years ago, ancient Egyptians were effectively used as antiseptics for embalming mummies. In addition to its efficacy as a preservative as described above for propolis, various papers and clinical reports by modern medicine suggest that propolis' anti-cancer, burn-healing, eczema, atopic dermatitis and athlete's foot are cured by skin fungi, such as athlete's foot, hair loss, etc. It has been reported to suppress and eliminate the pain of menstrual cramps, to remove constipation, skin care and wrinkles, and to cure and prevent bacterial dental diseases such as tooth decay, gingivitis and oral infections. It is defined as health supplement in 13-25.

In addition, flavonoids, one of the main components of propolis, are glycosides associated with sugars such as flavones, flavonones, flavonols, flavanols, flavanones, flavanols, and isoflavones, and glycosides thereof, and hundreds of anthocyanins and sugars. Its glycosides, combined with catechin and leucozancin as tannins, are known to have an immune boosting effect, bactericidal, analgesic and anti-inflammatory effects on flavonoids.

However, the use of such natural extracts alone is insignificant in many cases, so that the composition having a more effective antibacterial effect and showing a substantial effect on suppression of athlete's foot fungi is required.

The first technical problem to be achieved by the present invention is to provide an antimicrobial composition excellent in antimicrobial effect in order to solve the above problems.

The second technical problem to be achieved by the present invention is to provide a method for treating athlete's foot using the antimicrobial composition.

The third technical problem to be achieved by the present invention is to provide a method for improving the appearance of hair or scalp using the antimicrobial composition.

In order to achieve the first technical problem,

The present invention provides an antimicrobial active substance, such as the extract of the lint, propolis and zinc pyrithione; And

Surfactants as carriers and cleaners;

It provides an antimicrobial composition comprising a.

According to one embodiment of the present invention, the antimicrobial active substance in the antimicrobial composition is 0.01 to 5.0 wt% of the extract of Zillary; 0.1-5.0 wt% propolis; And 0.1 to 1.0% by weight of zinc pyrithione.

According to another embodiment of the present invention, it is preferable that the antimicrobial active substance in the antimicrobial composition further comprises plantain extract and Inchocho extract.

According to another embodiment of the present invention, the antimicrobial composition may contain 0.01 to 5.0 wt% of the extract of Zhulil; 0.1-5.0 wt% propolis; 0.1 to 1.0% by weight of zinc pyrithione; Plantain extract 0.1-5.0 wt%; 0.01-5.0 wt% of Indongcho extract; And 1 to 50% by weight of the surfactant; preferably includes.

According to another embodiment of the invention. The antimicrobial composition is 0.1% by weight of the extract of Zulu, 1.5% by weight of propolis, 1.1% by weight of zinc pyrithione suspension (zinc Omadine (48% by weight of zinc pyrithion)), plantain extract 0.3% by weight, phosphorus extract 0.1% by weight %, Thickener (carbopol 940) 0.25% by weight, preservative (Danisol-M (methyl-p-hydroxybezoate): 0.2% by weight, Danisol-P (propyl-p-hydroxybezoate): 0.05% by weight) 0.25% by weight, SLES (Micolin ES430, sodium lauryl ether sulfate (20.0%), SLS (Micolin S-430, sodium lauryl sulfate) 20.0% by weight, CDE (Micopol CDE, coconut diethanolamide) 2% by weight, LDE (Hisol LDE, lauryl diethanolamide) 1.3% by weight, 1.5% by weight of 2-hydroxyethyl octadecanoate (Hiemol EGS-D), 0.1% by weight of polymer (Polymer JR-400, polyquaternium-10), 0.7% by weight of creambazol, 2- (2-hydroxy -5-Methylphenyl) benzotriazole 0.4% by weight, EDTA-4Na 1% by weight, 0.13% by weight of carboxylic acid, 0.23% by weight of triethanolamine and the remaining amount of distilled water at the same time antibacterial and detergency It is preferable to be provided in the.

According to another embodiment of the present invention, it is preferable that the antimicrobial composition can be used as a spray formulation further including distilled water.

In order to achieve the second technical problem,

The present invention provides a method for treating athlete's foot, characterized in that the antimicrobial composition according to the above is applied to a person's foot in a safe and effective amount.

In order to achieve the third technical problem,

The present invention provides a method for improving the appearance of hair or scalp, which includes topically applying the antimicrobial composition to hair or scalp in need of appearance treatment.

According to the antimicrobial composition according to the present invention, by including the natural extracts, such as jouleum extract, propolis and zinc pyrithione has excellent antibacterial action against athlete's foot fungi, and can inhibit the foot odor, such as foot odor, and also inhibits dandruff, etc. It is possible.

Hereinafter, the present invention will be described in more detail.

The present invention provides an antimicrobial composition comprising juniper extract, propolis and zinc pyrithione as the antimicrobial active substance and surfactant as a carrier and detergent.

Briefly described about the known facts regarding the efficacy of the extract of the jouleus used in the present invention.

The fruit of the vine was once eaten as an old food. In the West, the fruit of the vine was called Wild Rice, or wild rice. Chinese characters were called gomi, or white porcelain, and koji.

Jelly is known to have excellent effects on various diseases by drying the leaves or stem roots in the shade and then boiling them with tea and drinking or fermenting them. Diabetes, high blood pressure, stroke, heart disease, constipation, obesity, arteriosclerosis, and other diseases, such as not only to cure the poison and the colon and stomach is said to be strong. It is also known that jellies are effective in improving the body's immunity. Finely chop the leaves or roots, dry them in the shade, and boil them with tea all the time. It is also known that jolts have therapeutic effects on rheumatoid arthritis. If you take a bath with a decoction of water frequently or ferment it for a long time, rheumatoid arthritis can be treated and prevented. Bathing in the boiled water is known to help with the skin's tenderness and help with skin diseases such as eczema, scabies, boils and sweat bands.

The present invention is excellent in antimicrobial activity, including propolis and zinc pyrithione known as such extracts and antimicrobial substances, and particularly excellent antibacterial effect against athlete's foot.

That is, by mixing three antimicrobial active substances having an individual antimicrobial effect can be obtained more improved antimicrobial effect by the synergy effect (synergy) between them.

0.01-5.0% by weight of the extract of the antibacterial active material in the antimicrobial composition; 0.1-5.0 wt% propolis; And 0.1 to 1.0% by weight of zinc pyrithione.

If the content of the extract is less than 0.01% by weight, the antimicrobial effect is insignificant, and when the content exceeds 5.0% by weight, the increase in antimicrobial performance is not large.

When the propolis content is less than 0.1% by weight, the antimicrobial effect is insignificant, and when the content is more than 5.0% by weight, the antibacterial performance increase is not large compared to the content increase.

If the amount of zinc pyrithione is less than 0.1% by weight, the antimicrobial effect is insignificant. If it exceeds 1.0% by weight, the antimicrobial effect is increased but the cosmetic use criteria are exceeded.

In the antimicrobial composition, it is preferable that the antimicrobial active material further comprises plantain extract and Inchocho extract. Plantain extract and Indongcho extract serves to further enhance the antimicrobial activity. Plantain extract is known to be effective in skin diseases such as atopic dermatitis, Indongcho extract is known to be effective in asthma and the like, when added to the antimicrobial composition of the present invention was shown to further improve the antibacterial.

More specifically, the antimicrobial composition may contain 0.01 to 5.0% by weight of the extract of Zillary; 0.1-5.0 wt% propolis; 0.1 to 1.0% by weight of zinc pyrithione; Plantain extract 0.1-5.0 wt%; 0.01-5.0 wt% of Indongcho extract; And 1 to 50% by weight of the surfactant; preferably includes.

Most preferably, the antimicrobial composition may contain 0.1% by weight of the extract of Zulea, 1.5% by weight of propolis, 1.1% by weight of zinc pyrithione suspension (zinc pyramid of 48% by weight), plantain extract 0.3% by weight, 0.1% by weight of copper extract, 0.25% by weight of thickener (carbopol 940), 0.25% by weight of preservative (Danisol-M (methyl-p-hydroxybezoate): 0.2%, Danisol-P (propyl-p-hydroxybezoate): 0.05%) , SLES (Micolin ES430, sodium lauryl ether sulfate) 20.0% by weight, SLS (Micolin S-430, sodium lauryl sulfate) 20.0% by weight, CDE (Micopol CDE, coconut diethanol amide) 2% by weight, LDE (Hisol LDE, laury diethanolamide ) 1.3% by weight, 2-hydroxyethyl octadecanoate (Hiemol EGS-D) 1.5% by weight, polymer (Polymer JR-400, polyquaternium-10) 0.1% by weight, creamazol 0.7% by weight, 2- (2-hydroxy-5-methylphenyl) benzotriazole) antibacterial including 0.4% by weight, 1% by weight of EDTA-4Na, 0.13% by weight of carboxylic acid, 0.23% by weight of triethanolamine and the remaining amount of distilled water Force and cleaning power at the same time.

Preferably, the antimicrobial composition of the present invention can be used as a spray formulation including distilled water. The preferred viscosity is not particularly limited as long as the spray is suitable to be sprayed, but is preferably 1 to 500 cps, and particularly preferably about 1 to 10 cps equal to water.

The surfactant used in the antimicrobial composition of the present invention is not particularly limited in its kind, and any surfactant used in the art may be used. Surfactants serve to emulsify the antimicrobial actives to make it easier to penetrate into the skin. The surfactant also performs a cleaning outline. The surfactant may be used in any form of surfactant such as anionic surfactant, nonionic surfactant or cationic surfactant.

Representative surfactants include, but are not limited to, sodium salt of lauryl sulfate, sodium salt of lauryl polyethoxy sulfate, lauryl acid diethanol amide, and the like.

It is preferable to use thickeners, preservatives, chelating agents, emulsifiers and the like as other additives.

The antimicrobial composition of this invention can be used for various uses. For example, when used in the shampoo formulation may be an antimicrobial shampoo composition that can prevent dandruff, etc., when used in the soap may be an antimicrobial soap composition that can prevent athlete's foot. It can also be used as a kind of body cleanser as a liquid soap.

In addition, when it is necessary to work with sustained release for a long time as an external preparation, it is also possible to prepare the antimicrobial active substance in a capsule encapsulated in a fine size. Encapsulation is preferably encapsulation using an emulsion, but is not limited thereto.

Meanwhile, the present invention provides a method for treating athlete's foot, characterized in that the antimicrobial composition according to the above is applied to a person's foot in a safe and effective amount. When the antimicrobial composition of the present invention is applied to a person's foot, it is effective in treating athlete's foot due to the antimicrobial effect, and particularly, it removes keratin, sludge, etc., and has an excellent effect on removing foot smell.

In another aspect, the present invention provides a method for improving the appearance of the hair or scalp by topically applying the antimicrobial composition to the hair or scalp in need of appearance treatment. That is, when dandruff occurs on the hair or the scalp, and the appearance problem occurs, the antimicrobial composition is effectively applied to the hair or the scalp to remove the dandruff.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, these are for illustrating the present invention and the scope of the present invention is not limited thereto.

Preparation of Natural Extracts

Preparation Example 1: Propolis Extract

After several weeks, the nylon mesh was placed on the side wall of the bee hive, and after several weeks, 0.3L high-purity (99.9%) ethanol was added to 100 g of the propolis ingot obtained by applying a propolis-containing solution to remove the hardened nylon mesh. Propolis was extracted by standing in a cow at 5 ° C for 2 days. It was then filtered using Whatman paper, the filtrate was concentrated using a rotary distiller and the remaining water was evaporated for 24 hours in a desiccator to give 9.2 g of propolis as a dark brown powder.

Preparation Example 2 extract

0.2 g of high purity (99.9%) ethanol was added to 16 g of the dried stems, leaves and roots of finely shredded grass, and left for 2 days at 5 ° C. to extract the active ingredient. It was then filtered using Whatman paper, the filtrate was concentrated using a rotary distillation, and the remaining water was evaporated for 24 hours in a desiccator to give 1.2 g of the extract of the juniper as a dark brown powder.

Preparation Example 3: Plantain Extract

0.2 g of high purity (99.9%) ethanol was added to 19 g of the dried stems, leaves and roots of finely sliced juniper powder, and left for 2 days at 5 ° C. to extract the active ingredient. It was then filtered using Whatman paper, the filtrate was concentrated using a rotary distillation, and the remaining water was evaporated for 24 hours in a desiccator to give 2.1 g of plantain extract as a dark brown powder.

Preparation Example 4: Indongcho Extract

0.2 g of high purity (99.9%) ethanol was added to 21 g of the dried stems, leaves, and roots of fine dried stems, and left for 5 days at 5 ° C. to extract the active ingredient. It was then filtered using Whatman paper, the filtrate was concentrated using a rotary distiller, and the remaining water was evaporated for 24 hours in a desiccator to give 1.4 g of the extract of the juniper as a dark brown powder.

Antimicrobial Composition Preparation

Example 1

0.1% by weight of the extract of Julle, 1.5% by weight of propolis, 0.528% by weight of zinc pyrithione, and the remaining amount of solvent were mixed to prepare a mixed antimicrobial composition having a total content of antibacterial active material of 2.128% by weight.

Antimicrobial evaluation test: disc-agar plate diffusion method

Test Examples 1 to 4

In the antimicrobial composition prepared in Preparation Example 5 in the mold medium to adjust the final content of the total antimicrobial active material 0.21% by weight, 1% by weight, 5% by weight, 10% by weight (Examples 2 to 5) for each concentration After addition, each medium was inoculated and incubated with test strains for activated tricophyton mentagrophite, epidermophyton phlocosm, and tricophyton rubrum. While incubating at 30 ° C. for 3 to 6 days, the growth pattern of the bacteria was observed in the medium added at each concentration. Five media were used to determine the average bacterial growth. Antimicrobial activity against athlete's foot fungus was evaluated as the degree of growth inhibition of athlete's foot fungus. If the growth of athlete's foot fungus is not inhibited, that is, the case of good growth as in Comparative Example 19 5, the case of no growth at all is set to 0, 0, 1, 2, 3, 4 depending on the degree of growth , One of five scores was judged to be effective when the mean score of five media was less than two.

Comparative Test Examples 1 to 18

Instead of the mixed antimicrobial composition used in the examples, only 0.005% by weight and 0.01% by weight of each of the extracts of Jouleum (Comparative Examples 1 to 6), Propolis (Comparative Examples 7 to 12), and zinc pyrithione (Comparative Examples 13 to 18) , 0.1% by weight, 1% by weight, 5% by weight, except that the addition was carried out at the same concentration was carried out in the same manner in the same manner as in the examples.

Comparative Example 19

The same procedure as in Example 1 was carried out simultaneously under the same conditions except that no antimicrobial material was added.

Degree of growth of bacteria Composition used Metagro Fight Proboscis Luv Room Example 1 1.9 1.9 1.9 Example 2 1.3 1.4 1.6 Example 3 1.0 1.1 1.2 Example 4 0.8 0.9 1.0 Comparative Example 1 4.1 4.0 3.9 Comparative Example 2 3.0 2.9 3.2 Comparative Example 3 2.7 2.7 2.8 Comparative Example 4 2.4 2.5 2.6 Comparative Example 5 2.3 2.2 2.3 Comparative Example 6 2.3 2.2 2.3 Comparative Example 7 4.2 4.3 4.2 Comparative Example 8 4.0 3.9 4.0 Comparative Example 9 3.2 3.1 3.2 Comparative Example 10 2.8 2.7 2.6 Comparative Example 11 2.5 2.4 2.4 Comparative Example 12 2.5 2.4 2.4 Comparative Example 13 3.8 3.7 3.6 Comparative Example 14 2.9 2.8 2.8 Comparative Example 15 2.5 2.5 2.4 Comparative Example 16 2.0 2.0 1.9 Comparative Example 17 1.6 1.5 1.4 Comparative Example 18 1.5 1.5 1.4 Comparative Example 19 5 5 5

As shown in Table 1, the mixed antimicrobial composition according to the present invention showed improved antimicrobial activity against athlete's foot fungus compared to the case of using a conventional antimicrobial alone.

Preparation of Antimicrobial Cleaning Composition

Example 6

0.1% by weight of the extract of Julle, 1.5% by weight of propolis, 1.1% by weight of zinc omadine (48% by weight of zinc pyrithion, 52% by weight of water), 0.3% by weight of plantain extract, 0.1% of copper extract %, Thickener (carbopol 940) 0.25% by weight, preservative (Danisol-M (methyl-p-hydroxybezoate): 0.2% by weight, Danisol-P (propyl-p-hydroxybezoate): 0.05% by weight) 0.25% by weight, SLES (Micolin ES430, sodium lauryl ether sulfate (20.0%), SLS (Micolin S-430, sodium lauryl sulfate) 20.0% by weight, CDE (Micopol CDE, coconut diethanolamide) 2% by weight, LDE (Hisol LDE, lauryl diethanolamide) 1.3% by weight, 1.5% by weight of 2-hydroxyethyl octadecanoate (Hiemol EGS-D), 0.1% by weight of polymer (Polymer JR-400, polyquaternium-10), 0.7% by weight of creambazol, 2- (2-hydroxy An antimicrobial cleaning composition was prepared by mixing 0.4% by weight of -5-methylphenyl) benzotriazole, 1% by weight of EDTA-4Na, 0.13% by weight of carboxylic acid, 0.23% by weight of triethanolamine, and the remaining amount of distilled water.

Comparative Example 20

In the antimicrobial cleaning composition of Example 6, 0.1% by weight of the extract of Julle, 1.5% by weight of propolis, zinc pyrithione (48% by weight of zinc pyrithione, 52% by weight of water) instead of 1.1% by weight of pro It was prepared in the same manner except that only 2.128% by weight of polis was used.

Comparative Example 21

Zinc in the antimicrobial cleaning composition of Example 6 0.1% by weight, propolis 1.5% by weight, zinc pyrithione (48% by weight zinc pyrithione, 52% by weight water) instead of 1.1% by weight It was prepared in the same manner except that only 2.128% by weight of pyrithione (dry basis) was used.

Comparative Example 22

In the antimicrobial cleaning composition of Example 6, 0.1% by weight of the extract of the lint, 1.5% by weight of propolis, zinc pyrithion (48% by weight of zinc pyrithione, 52% by weight of water) instead of 1.1% by weight It was prepared in the same manner except that only 2.128% by weight of the extract was used.

Antimicrobial Evaluation Test: Sensory Evaluation

Test Example 5 and Comparative Test Examples 20 to 22

Smells bad feet, 10 people for each of the 40 men with athlete's foot in the form of keratin and blemishes on the skin each 10 people to use the antimicrobial cleaning composition prepared in Example 6 and Comparative Examples 20 to 22 for 2 weeks daily Was evaluated. Athlete's foot symptoms were evaluated in three stages: improvement, immutability, and exacerbation. The state of the foot before and after using the Example 6 is shown in the figure divided into the state before use (FIG. 1), the 5th day after use (FIG. 2), and the 12th day after use (FIG. 3).

Composition used Improving immutability worse Test Example 5 Example 6 7 3 - Comparative Test Example 20 Comparative Example 20 3 7 - Comparative Test Example 21 Comparative Example 21 4 6 - Comparative Test Example 22 Comparative Example 22 3 7 -

As shown in Table 2, the antimicrobial cleaning composition according to one embodiment of the present invention showed an improved antimicrobial effect on people with athlete's foot compared to the comparative examples using a conventional antimicrobial alone. As shown in the figure, it can be seen that the phenomenon of exfoliation of skin keratin by athlete's foot is remarkably improved by using the antimicrobial composition of the present invention. This improved antimicrobial effect is thought to be because the antimicrobial materials used in the present invention are mixed with each other to synergize with each other to bring about an improved antimicrobial effect. On the other hand, even when the antimicrobial cleaning composition used in the hair showed an excellent effect to remove dandruff.

According to the antimicrobial composition according to the present invention, by including the natural extracts, such as jouleum extract, propolis and zinc pyrithione, excellent antibacterial action against athlete's foot fungi, etc., antibacterial action against athlete's foot fungi, such as foot odor suppression, and also inhibits dandruff, etc. It is possible.

Claims (8)

As antibacterial actives, extracts of joules, propolis and zinc pyrithione; And Surfactants as carriers and cleaners; Deodorizing antimicrobial composition comprising a. According to claim 1, wherein the antimicrobial active material is 0.01 to 5.0% by weight of the extract of the grass; 0.1-5.0 wt% propolis; And 0.1 to 1.0% by weight of zinc pyrithione; antimicrobial composition for odor removal comprising: a. According to claim 1, wherein the antimicrobial active material is an antimicrobial composition for removing odor, characterized in that it further comprises a plantain extract and Inchocho extract. The method according to claim 1, wherein 0.01 to 5.0% by weight of the extract; 0.1-5.0 wt% propolis; 0.1 to 1.0% by weight of zinc pyrithione; Plantain extract 0.1-5.0 wt%; 0.01-5.0 wt% of Indongcho extract; And 1 to 50% by weight of surfactant; Antimicrobial composition for odor removal comprising a. The method according to claim 1, wherein 0.1% by weight of the extract of Jawthorn, 1.5% by weight of propolis, 1.1% by weight of zinc omadine (48% by weight of zinc pyrithion content), plantain extract 0.3% by weight, phosphorus extract 0.1 wt%, 0.25 wt% thickener (carbopol 940), preservative (Danisol-M (methyl-p-hydroxybezoate): 0.2 wt% based on the total amount of the composition, Danisol-P (propyl-p-hydroxybezoate): 0.05 based on the total amount of the composition Weight%) 0.25 weight%, SLES (Micolin ES430, sodium lauryl ether sulfate) 20.0 weight%, SLS (Micolin S-430, sodium lauryl sulfate) 20.0 weight%, CDE (Micopol CDE, coconut diethanolamide) 2 weight%, LDE ( Hisol LDE, lauryl diethanolamide) 1.3% by weight, 2-hydroxyethyl octadecanoate (Hiemol EGS-D) 1.5% by weight, polymer JR-400, polyquaternium-10) 0.1% by weight, creambazol 0.7 0.4% by weight, 2- (2-hydroxy-5-methylphenyl) benzotriazole, 1% by weight EDTA-4Na, 0.13% by weight citric acid, 0.23% by weight triethanolamine and the remaining amount It can antibacterial activity and that the deodorant antimicrobial composition according to claim comprising a detergency at the same time comprises a. 6. The antimicrobial composition of claim 5, wherein the antimicrobial composition can be used as a spray formulation by additionally including distilled water. delete delete

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