KR102502242B1 - Toothpaste Composition for Cavum Oris Care and Toothpaste Containing Yellow Ocher - Google Patents

Abstract

The toothpaste composition for oral care of the present invention contains enzyme-treated stevia, ocher salt, xylitol as a sweetener, aminocaproic acid as an antipyretic agent, glycerin as a humectant, silicon dioxide, calcium hydrogen phosphate, precipitated calcium carbonate as an abrasive, It is characterized in that it includes Aerozil 200 and carboxymethylcellulose sodium (CMC) as thickeners, sodium bicarbonate as pH adjuster, grapefruit seed extract, peppermint essential oil and purified water as flavoring agents.
According to the present invention, it is effective for oral care as an alkaline toothpaste containing ocher salt, various naturally derived extracts, and vegetable oil substances. According to the present invention, it not only helps the acidified human body of people with weak immunity, such as cancer patients, to maintain neutral pH, but also neutralizes sulfur compounds, which are the cause of unpleasant odors, because they are acidic, so it has an excellent effect on removing bad breath. . Antibacterial component of the toothpaste composition of the present invention prevents gum inflammation due to antioxidant effect and antibacterial effect. has a mitigating effect.

Description

Toothpaste composition for oral care and toothpaste containing ocher salt {Toothpaste Composition for Cavum Oris Care and Toothpaste Containing Yellow Ocher}

The present invention relates to a toothpaste composition for oral care. More specifically, it relates to a toothpaste composition for oral care that can be safely used without using synthetic surfactant (SLS) that paralyzes the taste cells of the human body, and a toothpaste containing ocher salt.

Commonly used toothpaste compositions are distributed in the form of pastes, powders, gels, mucus or liquids for cleaning the oral cavity and teeth, and their use and handling have certain advantages and disadvantages.

Today, technology related to toothpaste is developing in the direction of improving oral hygiene by using various medicinal agents for the treatment and prevention of various oral diseases such as tooth decay, gingivitis, halitosis, and whitening, in addition to the basic functions of plaque removal and tooth cleaning. In particular, there is a tendency to develop extracts or essential oils of plants whose efficacy has been confirmed into toothpastes in powder form and use them for the treatment and prevention of oral diseases.

Patent Registration No. 10-1336726 relates to a toothpaste composition containing plant flower fragments, and cuts the flowers of a plant known to be effective in improving oral hygiene and treating or preventing oral diseases into appropriate sizes and contains them in the toothpaste composition. By doing so, it relates to a toothpaste composition that effectively delivers medicinal ingredients while giving a massage effect to the gums through a physical action during brushing. However, in this case, the color or flavor of the toothpaste changes during long-term storage of the toothpaste, reducing the effectiveness of the medicinal agent and causing discomfort during use, resulting in poor marketability.

Patent Registration No. 10-0859967 relates to a method for preparing toothpaste by treating an extract extracted from sawdust of Keumgang pine, which contains phytoncide as a natural preservative and essential oil, and uses an extract of Keumgang pine, which has antibacterial and antiseptic effects, It relates to a toothpaste with antibacterial, anti-inflammatory and antiseptic effects.

The prior art provides a toothpaste composition that realizes improved efficacy and effects compared to conventional toothpaste and a technology for preventing or alleviating gum inflammation by antioxidant effect, antibacterial effect, etc. by an antibacterial component.

It has been reported that synthetic surfactants contained in commercially available toothpastes can cause irritation or desquamation of mucosal cells or even cause ulcers and cause atopy on the skin. In addition, synthetic surfactants make the mouth more dry after brushing teeth, which can cause bad breath. An ideal mouthwash should exhibit selective antibacterial activity against the causative bacteria of dental caries and bacteria causing periodontitis or bad breath rather than normal tooth decay bacteria in the oral environment, and should have low toxicity to the human body and surrounding tissues.

Hydrogen ion concentration (pH) is a numerical value that indicates the degree of acidity or alkalinity of a substance. The balance between harmful bacteria and harmless bacteria in the oral cavity is determined by changes in the pH of the oral environment. A healthy person's saliva has a pH between 6.9 and 7. However, the fact that the inside of the oral cavity is acidified means that symptoms such as posterior teeth and inflammation, as well as a growth environment for harmful bacteria, can occur concurrently.

Cancer patients suffer from various side effects, complications, and sequelae due to the destruction of mucosal cells, including the oral cavity, due to a decrease in immunity during cancer treatment. Cancer patients experience inflammatory symptoms such as loss of taste, inhibition of salivary secretion, loss of appetite and stomatitis due to damage to mucosal cells in the oral cavity during treatment such as chemotherapy and radiation therapy.

When analyzing the cause of oral mucosal damage in cancer patients, cancer treatment, especially chemotherapy, reduces immune function, resulting in fatal damage to mucosal cells ranging from the oral cavity, airway, gastric mucosa, intestinal mucosa, liver, kidney, and bladder. Cancer patients lose their sense of taste due to a decrease in their sense of taste and smell, and their appetite decreases due to a decrease in the function of the salivary glands that promote appetite. When complications such as stomatitis become severe, the mucous membrane in the mouth becomes red and swollen, and swelling in the mouth may occur. In particular, in the case of cancer patients, infection easily occurs due to a decrease in resistance to germs and bacteria invaded from the outside due to a decrease in immunity.

Cancer patients have a sensitive oral cavity due to weakened immunity, so if they brush their teeth with a general synthetic toothpaste, they complain of discomfort such as tingling in the mouth due to severe stimulation, loss of appetite, loss of appetite, dry mouth, and dry mouth. The need for a toothpaste that can help is raised.

The present invention weakly alkalizes the pH of the oral cavity by using ocher salt for oral care of people with weak immunity, such as cancer patients, and synthesizes surfactants, pigments, preservatives, animal-derived raw materials, mineral oil, saccharin sodium, fluorine, etc. It relates to a toothpaste composition and toothpaste free of substances.

Registered Patent Publication No. 10-1336726 (Announcement date: 2013. 12. 04) Registered Patent Publication No. 10-0859967 (Publication date: 2008. 09. 25) Registered Patent Publication No. 10-0797365 (Public date: 2008. 01. 22) Registered Patent Publication No. 10-2203838 (Public date: 2021. 01. 14)

The present invention is to provide a toothpaste composition that can be safely used as an alkaline toothpaste containing ocher salt, various natural extracts, and vegetable oil substances for oral care.

The present invention not only helps the human body maintain a neutral pH, but also removes bad breath by neutralizing sulfur compounds (hydrogen sulfide, methyl mercaptan, etc.), which are the cause of unpleasant odors, because they are acidic. is to provide

The toothpaste composition for oral care of cancer patients of the present invention contains enzyme-treated stevia, ocher salt, xylitol as a sweetener, aminocaproic acid as an antipyretic agent, glycerin as a humectant, and silicon dioxide, calcium hydrogen phosphate, and precipitated calcium carbonate as an abrasive. And, it is characterized in that it comprises Aerozil 200, carboxymethylcellulose sodium (CMC) as a thickener, sodium bicarbonate as a pH adjusting agent, grapefruit seed extract, peppermint essential oil and purified water as a flavoring agent.

The toothpaste composition for oral care of cancer patients of the present invention contains 2 to 3% by weight of calcium hydrogen phosphate hydrate, 2 to 5% by weight of the precipitated calcium carbonate, and 0.2 to 1% by weight of aminocaproic acid, based on the total amount of the toothpaste composition. , Enzyme-treated stevia is 0.2 to 1% by weight, xylitol is 2.5 to 3.5% by weight, ocher salt is 2 to 4% by weight, glycerin is 30 to 40% by weight, carboxymethylcellulose sodium (CMC) is 1 to 3% by weight, Aerosil 200 is 1 to 3 wt%, silicon dioxide is 1 to 3 wt%, sodium bicarbonate is 1 to 3 wt%, grapefruit seed extract is 0.1 to 1 wt%, peppermint essential oil is 2 to 4 wt%, purified water Is characterized in that 45 to 55% by weight.

Toothpaste containing ocher salt in the present invention is characterized by comprising a toothpaste composition for oral care.

According to the present invention, due to the medicinal effect of ocher salt, various natural extracts, and vegetable oil, it is effective for oral care of people with weak immunity such as cancer patients.

According to the present invention, it not only helps the human body to maintain a neutral pH, but also neutralizes sulfur compounds (hydrogen sulfide, methyl mercaptan, etc.) that cause unpleasant odors because they are acidic, thereby eliminating bad breath. The toothpaste containing ocher salt of the present invention does not use synthetic surfactants that paralyze taste cells, so it does not foam, so it has the effect of giving a refreshing and refreshing finish after brushing teeth.

Hereinafter, examples and the like will be described in order to specifically describe the present invention.

Toothpaste composition for oral care according to an embodiment of the present invention contains enzyme-treated stevia, ocher salt, xylitol as a sweetener, aminocaproic acid as an antipyretic agent, glycerin as a humectant, silicon dioxide, calcium hydrogen phosphate as an abrasive, It is a composition in which precipitated calcium carbonate, Aerosil 200 and Carboxymethylcellulose Sodium (CMC) as thickeners, sodium bicarbonate as pH adjuster, grapefruit seed extract, peppermint essential oil and purified water as active ingredients are mixed as flavoring agents. .

The main components of the dentifrice composition are calcium hydrogen phosphate hydrate, precipitated calcium carbonate and aminocaproic acid. Calcium hydrogen phosphate hydrate forms a barrier on the dentin of the teeth to relieve pain and prevent tooth decay. Precipitated calcium carbonate is used as an abrasive to remove plaque. Aminocaproic acid is a pyorrhea preventive and prevents gum disease through anti-inflammatory and anti-thermal action. Enzyme-treated stevia is used as a sweetener and a substitute for saccharin.

Xylitol is used as a sweetener, but it is not digested by caries bacteria and inhibits the production of lactic acid to protect the enamel layer and prevent tooth decay. Ocher salt controls the pH in the oral cavity and serves to alkalinize it. Glycerin has the function of retaining moisture, preventing dryness in the mouth, and adsorbing and discharging substances. Sodium carboxymethylcellulose (CMC) and Aerosil 200 are used as thickeners to retain moisture, and silicon dioxide is used as a tooth polishing agent.

The balance of harmful bacteria and harmless bacteria in the oral cavity is determined by the pH of the oral environment. Sodium bicarbonate maintains alkalinity by adjusting the pH in the oral cavity, and adsorbs and discharges contaminants. Grapefruit seed extract is an antibacterial agent in place of preservatives, and peppermint essential oil stabilizes mucosal cells in the oral cavity and acts as an antibacterial agent, pain reliever, and bad breath prevention. Salt has been known to have anti-inflammatory, bactericidal, and antiseptic effects since ancient times.

Sea salt, obtained by natural evaporation of seawater in a salt farm, is a crystal of which sodium chloride is the main component, which is pulverized, washed, dehydrated, or dried. It contains many minerals such as Among them, Mg is known to have an anti-inflammatory effect, suppress the action of histamine, and stabilize eosinophil levels. Histamine is one of the organic substances secreted by the body to quickly act as a defense against external stimuli (stress). In other words, it is a substance that causes an inflammatory reaction (inflammation) in which the injured area becomes red and swollen and feels pain. Histamine is secreted by basophils and mast cells.

Bay salt has sterilization, anti-corruption, wound healing, skin protection, and anti-inflammatory effects, and has been used for various purposes such as maintaining oral hygiene or relieving inflammation since ancient times. In particular, the effect of reducing inflammation in periodontal tissues has been reported. . Bay salt contains abundant minerals and has the property of causing osmotic pressure, reducing swelling of the gums and suppressing the progression of gingivitis and bad breath, helping to maintain healthy gums. Oral care methods were utilized.

Ocher salt, one of the compositions of the present invention, is an alkali salt directly baked in ocher pottery, and is a burnt molten salt made by heating mineral-rich bay salt in a high-temperature loess kiln at a temperature of 790 ° C or higher for more than 12 hours. During the manufacturing process of ocher salt, far-infrared rays are emitted from loess to purify and decompose fine dust and natural suspended matter remaining in bay salt, and minerals in ocher are transferred to salt, making alkaline (pH 9.36) salt with high mineral content. As shown in Table 1 (unit: mg/kg), ocher salt has a very high mineral content compared to other salts.

mineral ocher salt Jeonnam bay salt Sea salt from China magnesium 13,703 9,645 4,240 potassium 4,950 3,465 936 calcium 3,937 1,296 990 strontium 116.08 65.63 45.42 steel 96.2 24.48 58.34 manganese 12.8 7.7 4.8 copper 25.01 0.97 0.99 zinc 83.25 0.66 0.62

Peppermint essential oil, which is one of the dentifrice compositions of the present invention, is a herbal aroma oil. Herb aroma oil is an essential component of representative medicinal plants used in herbal medicine, closely related to the physiological health of plants, and is a very important substance indispensable for immunity and growth. Aroma oil is also a storage of plant energy and a transmitter of information that sends and receives signals. In addition, it has the effect of inhibiting the growth of bacteria and fungi, preventing plant diseases. Aroma oils with such diverse functions have been proven to have excellent effects in preventing diseases in human health.

Fragrance is a volatile essential oil extracted from natural medicinal plants. Aroma (essential oil) is the most fundamental element that maintains the life of herbs as the “spirit of herbs” of medicinal plants. can be said to be applicable.

After all, aromatherapy means a method of extracting essential oil, which is the most fundamental substance for maintaining the life of herbs, and using it to maintain human physical and mental health.

There are about 90 types of aroma that can be used in the human body, and they can be used individually or 2-3 types can be mixed and used depending on the purpose. All aromas have excellent disinfection and antiseptic effects and have vitality with 100% pure natural ingredients.

Essential oils refer to oils extracted from flowers, fruits, leaves, stems, roots, barks, and resins of medicinal herbs. In general, essential oils are referred to as aroma oils, but these are not simple fats, but components with an ether group (R-O-R) that volatilizes very quickly. Peppermint essential oil refers to an essential aromatic oil component that has pharmacological effects on the human body among herbal plants. Therefore, it is a special component that exerts pharmacological effects and is an aroma component that is used for the treatment or prevention of specific diseases.

In particular, menthol, a major component of peppermint oil, cools the skin and mucous membranes, and is effective in antibacterial and pain relief, so it has been used as an important component of perfume in ancient Greece. In addition, it relieves mental fatigue and is effective for depression and nervous stress, and the ingredient that cools when it is hot and warms it when it is cold helps to reduce fever and sweat, and is effective for colds, asthma, bronchitis, cholera, pneumonia, tuberculosis, food poisoning, and neuralgia. It is used as a variety of home first-aid medicines using aroma.

The mixing ratio of the toothpaste composition for oral care according to an embodiment of the present invention is 0.2 to 1% by weight of enzyme-treated stevia, 2 to 4% by weight of ocher salt, 2 to 3% by weight of calcium hydrogen phosphate hydrate, 2 to 3% by weight of precipitated calcium carbonate 5% by weight, 0.2 to 1% by weight of aminocaproic acid, 2.5 to 3.5% by weight of xylitol, 30 to 40% by weight of glycerin, 1 to 3% by weight of sodium carboxymethylcellulose (CMC), 1 to 3% by weight of Aerozil 200, 1 to 3% by weight of Dioxide It consists of 1 to 3% by weight of silicon, 1 to 3% by weight of sodium bicarbonate, 0.1 to 1% by weight of grapefruit seed extract, 2 to 4% by weight of peppermint essential oil, and 45 to 55% by weight of purified water.

The best example of the blending ratio of the toothpaste composition for oral care obtained in the process of creating the present invention is as follows.

Toothpaste composition for oral care includes 2% by weight of calcium hydrogen phosphate hydrate, 3% by weight of precipitated calcium carbonate, 0.5% by weight of aminocaproic acid, 0.27% by weight of enzyme-treated stevia, 3% by weight of xylitol, 2% by weight of ocher salt, 30% by weight of glycerin %, sodium carboxymethylcellulose (CMC) 1.1% by weight, Aerosil 200 2.5% by weight, silicon dioxide 1% by weight, sodium bicarbonate 2% by weight, grapefruit seed extract 0.5% by weight, peppermint essential oil 2.8% by weight, purified water It consists of 49.33% by weight.

Cancer patients suffer from inflammatory symptoms such as loss of taste, suppression of salivary gland secretion, loss of appetite and stomatitis because damage to mucosal cells in the oral cavity is further aggravated during intensive treatment such as chemotherapy and radiation therapy.

The causes of oral mucosal damage in cancer patients are : ① Cancer treatment, especially chemotherapy, reduces immune function, resulting in fatal damage to mucosal cells ranging from the oral cavity, airway, gastric mucosa, intestinal mucosa, liver, kidney, and bladder; ② Taste and smell Decreased sense of taste due to decrease in taste, loss of appetite due to decreased function of salivary glands that promote appetite ③ When complications such as stomatitis worsen, the mucous membrane in the mouth becomes red and swollen and oral edema occurs, ④ Bacteria invaded from the outside due to reduced immunity, Infection easily occurs due to a decrease in resistance to bacteria.

Stomatitis in cancer patients undergoing intensive care is caused by the damage of oral epithelial cells due to active oxygen generated by toxic treatment such as chemotherapy and by the influence of inflammatory cytokines generated in the process of mucosal tissue death. When using anticancer drugs such as Cisplatin and Gemcitabine during chemotherapy, the incidence of stomatitis of grade 3 or higher is 47%, and salivary change and burning sensation caused by stomatitis and oral discomfort such as difficulty swallowing can cause decreased nutritional intake, pain, and systemic sepsis. .

Stomatitis is a life-threatening symptom of cancer patients, and effective oral care for preventing stomatitis should be provided to patients receiving chemotherapy.

In addition, chemotherapy changes the sense of taste. The taste bud has a very high cell turnover, but the number of taste bud cells decreases due to the presence of cancer and cancer treatment. In advanced cancer, perceptual abnormalities for sweet or bitter taste occur frequently, lowering the perceptual threshold (Williams & Cohen, 1978). These changes cause anorexia by reducing food intake and avoiding certain foods. When stomatitis occurs, patients do not brush their teeth and food intake through the mouth is reduced, so patients are more likely to have poor oral hygiene. Therefore, the patient feels bad breath and oral dryness, and when a bacterial infection is accompanied, the patient becomes more uncomfortable due to pain.

The bias in the balance between harmful bacteria and harmless bacteria in the oral cavity is determined by changes in pH, which is an oral environment. The pH of saliva is between 6.9 and 7. Acidification in the oral cavity means that symptoms such as posterior teeth and inflammation, as well as a proliferative environment for harmful bacteria, can occur concurrently. The oral pH of cancer patients is acidified.

The following graph shows data obtained by comparing and evaluating salivary pH and amylase levels of normal people, cancer patients before treatment, and cancer patients during treatment. Saliva samples from 90 people were collected and tested by dividing them into 3 groups: 30 healthy people (group A), 30 cancer patients before treatment (group B), and 30 cancer patients under treatment (group C). It can be seen that amylase salivary secretion and pH are decreased in . Cancer patients have lower oral pH compared to normal people.

It can be seen that the secretion of salivary enzymes is also reduced compared to normal people.

The present invention is the result of research and development of a toothpaste for oral care of cancer patients in order to improve the immune-suppressed state of cancer patients through oral care, which is the first gateway to the human immune system.

In a situation where the immune function of immune cells is lost and cancer cells evade immune cells, the condition of cancer patients deteriorates and recovery is delayed. The purity of prayer is of the utmost importance. The composition of the toothpaste for oral care of the present invention contains alkali ocher salt and uses ingredients harmless to the human body because it does not use a surfactant. Use low-abrasive adsorption method. Maintains the original taste of food after brushing.

According to the present invention, it not only helps the acidified human body of people with weak immunity, such as cancer patients, to maintain neutral pH, but also neutralizes sulfur compounds, which are the cause of unpleasant odors, because they are acidic, so it has an excellent effect on removing bad breath. .

Toothpaste containing ocher salt of the present invention includes a toothpaste composition for oral care, and may be prepared according to a method conventionally prepared in the art.

Although the preferred embodiments of the present invention have been described above, it should be interpreted that the scope of the present invention extends to the extent substantially equivalent to the embodiments of the present invention, and the technical field to which the present invention belongs within the scope of the technical spirit of the present invention. Various modifications are possible by those skilled in the art.

The toothpaste composition for oral care of the present invention can help the acidified human body of people with weak immunity, such as cancer patients, maintain a neutral pH, and since sulfur compounds are acidic, they neutralize them to have an excellent effect on removing bad breath. Therefore, it is a very useful invention for the medical industry.

Claims (3)

In the dentifrice composition,
Enzyme-modified stevia, ocher salt, and xylitol as sweeteners, aminocaproic acid as antipyretic agents, glycerin as humectant, silicon dioxide, calcium hydrogen phosphate hydrate, and precipitated calcium carbonate as abrasives, Aerosil 200 and carboxymethylcellulose as thickeners Contains sodium (CMC), sodium bicarbonate as a pH adjusting agent, grapefruit seed extract, peppermint essential oil and purified water as flavoring agents,
The loess salt is an alkali salt baked directly in ocher pottery, and is a burnt molten salt made by heating mineral-rich bay salt in a high-temperature ocher kiln at a temperature of 790 ° C or higher for 12 hours or more,
With respect to the entire toothpaste composition, 0.2 to 1% by weight of enzyme-treated stevia, 2 to 4% by weight of ocher salt, 2.5 to 3.5% by weight of xylitol, 0.2 to 1% by weight of aminocaproic acid, and 30 to 40% by weight of glycerin %, silicon dioxide is 1 to 3 wt%, calcium hydrogen phosphate hydrate is 2 to 3 wt%, precipitated calcium carbonate is 2 to 5 wt%, Aerosil 200 is 1 to 3 wt%, and carboxymethylcellulose sodium (CMC) is 1 to 3 wt%. Oral care, characterized in that 1 to 3% by weight, 1 to 3% by weight of sodium bicarbonate, 0.1 to 1% by weight of grapefruit seed extract, 2 to 4% by weight of peppermint essential oil, and 45 to 55% by weight of purified water Toothpaste composition for.
delete Toothpaste containing ocher salt comprising the toothpaste composition for oral care of claim 1.