KR101963215B1 - Oral cleansing composition containing rice bran, rice straw, hog millet - Google Patents

Abstract

The present invention relates to a composition for oral cleaning comprising rice bran, rice straw and millet. The composition for oral cleaning according to the present invention comprises natural rice powder, rice straw, millet, natural magnesium carbonate, glycerin, gum arabic, xylitol, Essential oil, grapefruit seed extract, dental silica, propolis and solvents are effective in removing plaque, inhibiting bad breath and improving periodontal disease.

Description

Technical Field [0001] The present invention relates to an oral cleansing composition containing rice bran, rice straw and hog mill,

The present invention relates to a composition for oral cleaning comprising rice bran, rice straw and millet. The composition for oral cleaning according to the present invention comprises natural rice powder, rice straw, millet, natural magnesium carbonate, glycerin, gum arabic, xylitol, Essential oil, grapefruit seed extract, dental silica, propolis and solvents are effective in removing plaque, inhibiting bad breath and improving periodontal disease.

It is known that about 600 to 800 or more microorganisms are present in human oral cavity. Oral microorganisms are controlled by enzymes such as saliva lysozyme, but the oral environment and plaque provide good conditions and habitats for microbial growth. Among microorganisms in the oral cavity, certain microorganisms cause oral diseases. Most diseases occurring in the oral and maxillofacial area such as dental caries and periodontal diseases, dental and periapical infections, and jaw injuries are originated from oral microorganism infections.

A tooth plaque is a colorless bacterial film formed continuously on the tooth surface, which corresponds to the pre-calculus stage and is a major cause of periodontal disease. Bacteria in the plaque produce toxins and free oxygen, destroying tissues surrounding the teeth and causing irritation to the gums. The plaque is combined with minerals to form tartar, plaque builds up more plaque, bad breath occurs, unremoved plaque accumulates in the periodontal pocket between the gums and teeth, descends along the root surface, The bone is destroyed and the tooth is lost in severe cases.

Dental caries, which is a common dental disease in oral cavity, is caused by the bacteria that form the plaque, which breaks down the sugars and damages the tooth enamel by producing acid, which is also called tooth decay. Streptococcus mutans and lactobacillus are known to be major bacteria of dental caries, and Mutans streptococci and lactic acid bacteria are widely used as an index for evaluating dental caries activity. Dental caries is caused by bacteria that damage the enamel of the tooth and may progress to dental infection if the damage becomes worse.

Other commonly occurring oral diseases include stomatitis, gingivitis, bad breath, and dry mouth. These oral diseases are caused by various causes such as stress, respiratory diseases, digestive diseases, etc. However, the most important cause is oral condition, periodontal disease and unclean oral hygiene.

Therefore, modern people use various oral products such as toothpaste, mouthwash, and floss to manage the mouth cleanly. The most commonly used dentifrices include chemicals such as abrasives, polishes, fluoride, preservatives, and antimicrobial agents to enhance the oral cleaning effect. The chemicals contained in the toothpaste have the effect of removing the plaque of the tooth and suppressing the bacteria in the mouth to suppress the bad breath, but it has a problem of stimulating the teeth and oral mucosa or causing side effects to the human body.

For example, when fluoride is applied to a tooth, it is deposited on the tooth surface to increase the hardness of the tooth surface, to increase the acid resistance of the tooth surface, or to promote resorption of the demineralized tooth surface, thereby preventing dental caries. Such fluoride is absorbed or ingested into the body when gargling, and excessive intake of fluoride over a long period of time may cause spots on the teeth and may cause fluorosis.

In another example, the abrasive is used to physically wipe the plaque of the tooth, and is classified into various types according to the hardness, size and shape of the abrasive particles, and has a great influence on the toothbrush wear. The greater the wear of the toothpaste, the greater the removal effect of the plaque. However, the wear of the tooth must be as small as possible to the extent that it can remove the dentine bacterial membrane, Mainly used abrasives include calcium monohydrogenphosphate, light calcium carbonate, heavy calcium carbonate, precipitated silica, silica gel, hydrated alumina, zirconium silicate, calcium anhydrous calcium phosphate, calcium pyrophosphate, hydroxyapatite, insoluble metaphosphate and aluminum silicate . Long-term use of toothpastes containing such abrasives can cause cervical erosion, and dental bleeding can occur if the dentin of the cervical area continues to wear.

For this reason, in order to reduce and replace the use of fluorine and abrasives, studies on toothpaste that does not contain an abrasive have been conducted, and Korean Patent Laid-Open Publication No. 10-1997-0005269 discloses a related art. The above-mentioned prior art relates to a dentifrice composition which does not contain an abrasive, and it has an effect of reducing the occurrence of cervical erosion or hypersensitive teeth without an abrasive agent, but has little effect of removing plaque from teeth.

Another prior art that improves this is Korean Patent No. 10-1019873, which relates to a dentifrice composition that provides chemical cleaning of the oral surface using a combination of surfactant, chelating agent and pH. In the above-mentioned prior art, although the damage of the tooth surface due to the abrasive agent is reduced by using a small amount of the abrasive agent, there is little effect of preventing excessive use of the chelating agent to prevent odor removal and oral disease.

Accordingly, there is a demand for a composition for oral cleaning which is excellent in the effect of preventing plaque removal, bad breath suppression and oral diseases of teeth, and not stimulating teeth and oral cavity.

The inventors of the present invention have studied for a composition for oral cleaning which removes plaque without damaging the teeth and is effective for removing bad breath and oral diseases. As a result, it has been found that a composition for oral cleaning comprising a natural powder composed of rice bran, rice straw, The present invention has been accomplished on the discovery that there is no irritation to teeth and oral cavity, and it is effective for plaque removal, bad breath suppression and oral disease.

The present invention provides a composition for oral care comprising natural powder of rice bran, rice straw and millet, magnesium carbonate, glycerin, gum arabic, xylitol, apple wash, essential oil, grapefruit seed extract, dental silica, propolis and solvent There is a purpose.

In order to attain the above object, the present invention provides a method for producing a natural product comprising a natural powder composed of rice bran, rice straw and millet, magnesium carbonate, glycerin, gum arabic, xylitol, apple wash, essential oil, grapefruit seed extract, dental silica, propolis, A composition for oral cleaning is provided.

The composition for oral cleaning of the present invention can be used for oral care including a natural powder consisting of rice bran, rice straw and millet, magnesium carbonate, glycerin, gum arabic, xylitol, apple wash, essential oil, grapefruit seed extract, dental silica, propolis, It has the effect of removing plaque while reducing the damage on the surface, the effect of suppressing bad breath, the effect of inhibiting the growth of periodontal bacteria, preventing dental caries, and improving periodontal disease.

The present invention provides a composition for oral care comprising natural powder consisting of rice bran, rice straw and millet, magnesium carbonate, glycerin, gum arabic, xylitol, apple wash, essential oil, grapefruit seed extract, dental silica, propolis and a solvent .

Hereinafter, the present invention will be described in more detail.

The natural powder of the present invention is preferably pulverized and mixed with rice bran, rice straw and millet, respectively, and the rice bran: rice straw: millet is preferably mixed at a weight ratio of 3: 6: 1: 1 to 3: This is an optimum ratio for reducing plaque elimination, bad breath suppression and oral disease, and more preferably, the ratio of rice bran: rice straw: bean is mixed at a weight ratio of 5: 1: 2.

The natural powder is preferably 5 to 40% by weight based on the total weight of the oral cleaning composition. If the content of the natural powder is less than 5% by weight, the effect of removing plaque, inhibiting the growth of periodontal bacteria, and alleviating periodontal disease becomes insignificant. If the content is more than 40% by weight, the formulation stability and long- There is a falling problem.

The particle size of the natural powder preferably has a particle size of 1 to 10 mu m. If the particle size of the natural powder is less than 1 탆, the effect of removing the plaque becomes insignificant. If the particle size is more than 10 탆, the effect of removing the plaque by polishing the teeth is improved but the enamel quality of the teeth may be damaged.

The rice bran of the present invention refers to rice husks, rice bran, and rice husks separated in the process of making rice flour and rice flour. The rice husk, rice bran, and rice gruel produced when rice is cultivated in the Chuncheon area are mixed and used. Rice bran contains 95% of rice nutrients, and contains 100 kinds of nutrients such as protein, fiber, and vitamins. Gamma oryzanol, vitamin B group, tocopherol, flavonoid, and phytosterol among the nutrients contained in rice bran are known to have effects such as inhibition of aging of cellular DNA, skin soothing and skin whitening. It is also known that rice bran has antimicrobial activity against periodontal bacteria and vitamins and minerals from rice bran are effective in preventing periodontal disease.

The rice straw of the present invention is one of the byproducts generated when rice is thawed. It refers to the stem and leaves that have dropped the rice, and the stem and leaves that occur when threshing the rice grown in Chuncheon are used, Select clean rice straws to use. Fully grown rice straw contains 36% cellulose, 20% lignin, 22% pentanoic acid, 6% crude protein and 13% ash, and contains organic germanium, silicate and minerals. In Oriental medicine, rice straw has been used for the treatment of indigestion, diarrhea, enteritis, inflammatory epigastric diseases and various dermatitis.

The capillary (Panicum miliaceum) of the present invention is also referred to as a summery, similar in shape to Joe but different from Joe and uses a yellow plaque. The digestive tract contains proteins, carbohydrates, lipids, dietary fiber, folic acid, phosphorus, iron, ash, and vitamin A, but it has a lower digestibility than white rice. In Oriental medicine, the captain has the effect of strengthening the digestive system and strengthening the digestive organs. It is used for coughing, nausea, stomach pain, diarrhea, leprosy, pediatric thrush. The capitals are moon, boiled or killed or taken as a sole, and burns and pastes are added to burns or salt.

The magnesium carbonate of the present invention serves to adjust and maintain the pH of the oral cleaning composition, and the content thereof is preferably 5 to 20% by weight based on the total weight of the oral cleaning composition. If the content of magnesium carbonate is less than 5% by weight, the pH of the oral cleaning composition may be lowered to cause damage to the tooth surface. If the content exceeds 20% by weight, excessive wear may occur due to magnesium carbonate.

The glycerin of the present invention imparts moisture and luster to the composition for oral cleaning, so that the composition for oral cleaning has a cream, ointment or paste formulations. The content of glycerin is preferably 10 to 20% by weight based on the total weight of the oral cleaning composition. If the content of glycerin is less than 10% by weight, the oral cleaning composition can not be made into an ointment, cream, or paste form, and can be solidified when the oral cleaning composition is exposed to air. When the content of glycerin is more than 20% by weight, there is a problem that an antiseptic agent is excessively contained to inhibit the growth of bacteria and fungi.

A high viscosity dispersion is produced from the arabic black water-soluble polymer of the present invention to prevent the solid component and the liquid component of the oral cleaning composition from being separated, and the viscosity of the oral cleaning composition is adjusted. The content of the gum arabic is preferably 10 to 20% by weight based on the total weight of the oral cleaning composition. When the content of the gum arabic is less than 10% by weight, the solid component and the liquid component of the oral cleaning composition are separated from each other to lower the formulation stability of the oral cleaning composition. When the content exceeds 20% by weight, the viscosity of the oral cleaning composition It may be difficult to prepare the oral cleaning composition, and the dispersibility may be deteriorated when the oral cleaning composition is used.

The apple wash of the present invention is made by acylation of the essential amino acid obtained from apple juice and is sometimes called sodium cocoyl apple amino acid. The apple wash is a surfactant that does not denature skin proteins and does not irritate the skin. The content of the apple wash is preferably 10 to 20% by weight based on the total weight of the oral care composition. If the content of the apple wash is less than 10% by weight, the feeling of use and the cleaning effect of the composition for oral cleaning deteriorate. If the content of the apple wash is more than 20% by weight, excessive bubbles may occur during use of the oral cleaning composition.

The xylitol of the present invention serves as a sweetener of the oral cleaning composition, which gives a cooling sensation to the oral cleaning composition and reduces the formation of plaque. Mutant Streptococcus, one of the cariogenic bacteria, is known to fail to use xylitol for metabolism. As a result, xylitol has the effect of inhibiting the formation of plaque by reducing the growth of bacteria. The content of xylitol is preferably 3 to 10% by weight based on the total weight of the oral cleaning composition.

The essential oil of the present invention acts as a flavoring agent of the composition for oral cleansing, and thus has an effect of suppressing bad breath and relieving pain. It is preferable to use at least one selected from the group consisting of basil oil, clove oil, peppermint oil and spearmint oil. The content of the essential oil is preferably 0.5 to 2% by weight based on the total weight of the oral care composition. If the content of the essential oil is less than 0.5% by weight, the effect of suppressing the odor and bad breath of the composition for oral cleansing is inferior due to the insufficient content. If the content exceeds 2% by weight, the specific odor and bad breath of the composition for oral cleansing The effect of inhibiting is not greatly increased.

The grapefruit seed extract of the present invention contains ascorbic acid, naringin, and tocopherol, and thus has excellent antimicrobial and antioxidative activity, and has an effect of inhibiting the production of toxic and transformed products. When the grapefruit seed extract is absorbed into the body, it is completely decomposed and is not toxic to the human body, and the naringin of the grapefruit seed extract has a bitter taste. The content of the grapefruit seed extract is preferably 1 to 2% by weight based on the total weight of the oral cleaning composition. If the content of the grapefruit seed extract is less than 1% by weight, the preservative effect and the antibacterial activity are inferior because the content is insufficient. If the content is more than 2% by weight, the taste of the mouthwash may be discomforted.

The dental silica of the present invention is in the form of an odorless white powder, has a property of not stimulating the oral mucous membrane, and can be included as a polishing aid for a composition for oral cleaning. The content of the dental silica is preferably 5 to 10% by weight based on the total weight of the oral cleaning composition. If the content of the dental silica is less than 5% by weight, the polishing performance of the oral cleaning composition is low and the basic cleaning action is insufficient. If the content is more than 10% by weight, the polishing force may increase and the teeth may be damaged. The larger the size of the dental silica is, the better the polishing effect is, but the dental silica may have a possibility of damaging the enamel of the teeth, and the particle size of the dental silica is preferably 1 to 10 탆.

The propolis of the present invention is an antibacterial substance extracted from a honeycomb, and contains 20 to 30 types of flavonoids, minerals, vitamins, amino acids, organic acids and the like, thus exhibiting antibacterial, anti-inflammatory and bactericidal effects. The propolis prevents contamination of microorganisms that may occur during preparation and use of the composition for oral cleaning, and improves the long-term preservability of the oral cleaning composition. The content of the propolis is preferably 1 to 2% by weight based on the total weight of the oral cleaning composition. If the content of propolis is less than 1% by weight, the preservative effect and the antibacterial activity are inferior because the content is insufficient. If the content is more than 2% by weight, the preservative effect does not increase significantly.

The solvent of the present invention may be selected from the group consisting of purified water and ethanol. The content of the solvent is preferably 3 to 5% by weight based on the total weight of the oral cleaning composition. If the content of the solvent is more than 5% by weight, the composition for oral cleansing has a low adhesive force to the tooth surface, and the effect of removing the plaque is deteriorated.

In addition, the composition for oral care of the present invention may further contain commonly used additives depending on the purpose of formulation and use, and sweeteners, pigments, potentiators and perfumes may be added as additives. .

The sweetener may be selected from the group consisting of sodium saccharin, aspartame, stevioside, licorice, sorbitol and the like. An edible pigment may be used as the colorant. Examples of the enhancer include allantoin, aninocaproic acid, sodium pyrophosphate, potassium nitrate , Potassium chloride, and potassium phosphate can be selected and used. As the above-mentioned fragrance, edible, menthol, green tea flavor, sage oil, plant extract and the like can be used.

Hereinafter, the method for producing the natural powder of the present invention will be described in detail.

The natural powder of the present invention is preferably obtained by pulverizing and mixing raw rice straw, rice straw and millet, respectively, and may be prepared by mixing rice bran, rice straw and millet, followed by pulverization.

First, rice bran is washed with purified water three times to remove impurities sufficiently, and then sterilized at a temperature of 50 to 60 ° C for 20 to 30 minutes in a pasteurizer. The microfibers treated with sterilization are dried at a temperature of 40 to 50 ° C. for 10 to 12 hours so that the moisture content is 10 to 20%. The dried untreated steel is subjected to a primary milling step of milling to 20 탆 which is a condition of an abrasive for toothpaste. The larger the size of the abrasive is, the better the abrasive effect is. However, there is a possibility of damaging the enamel of the tooth, and the unfermented raw steel having a particle size of 20 탆 is subjected to a second milling step so as to have a particle size of 1 to 10 탆 do.

Using the above method, the rice straw and the mill are pulverized to have a particle size of 1 to 10 mu m. Using the method described above, ground rice straw, rice straw and millet having a particle size of 1 to 10 mu m are mixed to prepare a natural powder.

The natural powder of the present invention is preferably used by mixing raw ground rice straw, rice straw and millet with a particle size of 1 to 10 탆 at a weight ratio of 3 to 6: 1: 1 to 3. This is an optimum ratio for reducing plaque elimination, bad breath suppression and oral diseases, and more preferably, the ratio of rice bran, rice straw and millet is mixed at a weight ratio of 5: 1: 2.

The first and second pulverization processes of the present invention preferably use wet pulverization. Methods of pulverizing food raw materials include dry grinding and wet grinding. Dry grinding is a method of pulverizing a dry material in advance, which is advantageous in that the process is simple and time-saving, but the nutrients are destroyed by heat and mechanical friction generated in the grinder, loss of yield due to dusting occurs, There is a disadvantage in that the sizes of the particles are not uniform. On the other hand, wet milling is a process in which grains are dispersed and pulverized while being soaked, so that there is no aggregation between the raw materials, the milling can be performed with a uniform particle size, and the loss of nutrient destruction and yield of the raw material is small.

Hereinafter, the present invention will be described in more detail with reference to Production Examples, Examples, Comparative Examples and Test Examples. These production examples, examples, comparative examples and test examples are for illustrating the present invention, and the scope of the present invention is not limited thereto.

Production Example 1. Preparation of Natural Powder

First, rice bran, rice straw and millet were washed three times with purified water, respectively, and sterilized at a temperature of 55 ° C for 30 minutes in a pasteurizer. The sterilized rice bran, rice straw and millet were respectively dried at a temperature of 45 ° C for 10 to 12 hours so that the moisture content was 10 to 20%. The dried rice bran, rice straw and millet were wet pulverized with a particle size of 20 μm, and then pulverized rice bran, rice straw and millet were mixed at a weight ratio of 5: 1: 2 to prepare a natural powder.

Production Examples 2 to 5. Preparation of Natural Powder

First, rice bran, rice straw and millet were washed three times with purified water, respectively, and sterilized at a temperature of 55 ° C for 30 minutes in a pasteurizer. The sterilized rice bran, rice straw and millet were respectively dried at a temperature of 45 ° C for 10 to 12 hours so that the moisture content was 10 to 20%. The dried rice bran, rice straw and millet are ground to a particle size of 20 mu m through a first milling step, and then pulverized to 1 to 10 mu m through a second milling step. Rice bran, rice straw and millet pulverized to 1 to 10 mu m were mixed at the following weight ratios to prepare a natural powder.

Production Example 2: rice bran: rice straw: millet was mixed at a weight ratio of 5: 1: 2.

Production Example 3: rice bran: rice straw was mixed at a weight ratio of 5: 1.

Production Example 4: Mixed rice bran: length of 2.5: 1 by weight.

Production Example 5: Rice straw: The rice straw was mixed at a weight ratio of 1: 2.

Examples 1 to 5 and Comparative Examples 1 to 2. Preparation of Oral Cleansing Composition

The oral cleaning compositions of Examples and Comparative Examples were prepared by mixing the ingredients and compositions shown in Table 1 below. First, magnesium carbonate, gum arabic and dental silica were dispersed in glycerin, and the mixture was firstly mixed in a mixer, followed by secondary mixing by adding natural powder, xylitol, grapefruit seed extract and propolis, and finally Essential oil and apple wash were mixed and mixed to prepare a composition for oral cleaning.

Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 The natural powder of Preparation Example 1 35 - - - - - - The natural powder of Preparation Example 2 - 35 - - - - - The natural powder of Preparation Example 3 - - 35 - - - - The natural powder of Preparation Example 4 - - - 35 - - - The natural powder of Preparation Example 5 - - - - 35 - - Calcium carbonate - - - - - 35 - Precipitated silica - - - - - - 35 Magnesium carbonate 10 10 10 10 10 10 10 glycerin 15 15 15 15 15 15 15 Arabian sword 11 11 11 11 11 11 11 Xylitol 5 5 5 5 5 5 5 Apple Wash 10 10 10 10 10 10 10 Essential Oils One One One One One One One Grapefruit seed extract 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Dental silica 6 6 6 6 6 6 6 Propolis 1.5 1.5 1.5 1.5 1.5 1.5 1.5 solvent Balance Balance Balance Balance Balance Balance Balance

Test Example  One. Composition for oral cleaning  Wear rate evaluation

In order to evaluate the wear of teeth on the compositions for oral cleaning of the examples and the comparative examples, the extracted human teeth were examined in vitro using the following experimental methods, and the results are shown in Table 2 below.

Except for the area 2 mm in the center of the dentin specimen, was covered with PVC tape to expose only the experimental site. The exposed test site was diluted with a 2: 1 dilution of the composition for oral cleaning and the artificial saliva of the examples and comparative examples A total of 1,000 brushing operations were performed at a rate of 100 reciprocations per minute using a brushing machine under the force of an adult's brushing pressure of 250 g. 20 ml of artificial saliva was added every 200 brushings in consideration of dilution of the oral cleaning composition by the incorporation of saliva during brushing. After dentin specimens were dried at room temperature, the surface area of the dentin specimens worn by brushing was calculated by surface profile meter (Mitutoyo SV-3000, Japan). The same experimental procedure was performed using a standard toothpaste (toothbrush according to British Standard BS 5136) to obtain the wear area values, and the comparative tooth wear values of the oral cleaning compositions of the examples and comparative examples were calculated.

Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative tooth wear 29 18 22 12 13 86 68 Comparative tooth wear = Wear area of the composition for oral cleaning of the examples and comparative examples / Wear area of the standard toothpaste x 100

As shown in Table 2, it can be seen that Examples 1 to 5 have significantly less tooth wear than Comparative Examples 1 and 2, and that the composition for oral cleaning containing natural powder is superior to the oral care compositions It can be seen that the tooth irritation and damage are less than that of the cleaning composition.

Comparing Examples 1 and 2, it can be seen that the wear resistance of the tooth of Example 1 is greatly increased. In Examples 1 and 2, the kinds and contents of the respective components are the same, and the particle size of the natural powder is different. That is, when the particle size of the natural powder is large, the polishing effect of the teeth is improved, Able to know.

Comparing Examples 2 to 5, it can be seen that Examples 2 and 3 are greater in tooth wear than Examples 4 and 5. Among the compositions for oral cleaning including natural powders, it can be seen that the polishing effect of the tooth is high when the composition contains both rice bran and rice straw.

Test Example 2. Effect of removing plaque from composition for oral cleaning

In order to evaluate the plaque removal effect of the oral cleaning compositions of the above Examples and Comparative Examples, 70 subjects who were relatively dentate and without dental caries were selected and the plaque index was measured by Quigley & Hein's Turesky modification method, The results are shown in Table 3 below.

Before the experiment, the plaque index of the subject was measured, and the users of Examples 1 to 5 and Comparative Examples 1 and 2 were each divided into 10 persons. Subjects were instructed to use the same toothbrush as the oral cleaning compositions of Examples 1 to 5 and Comparative Examples 1 and 2 for 14 days and then examined for plaque index. At this time, the composition for oral cleaning and the toothbrush were used three times a day, and the use of the provided oral cleaning composition and oral hygiene products other than toothbrush was discontinued.

The plaque index was obtained by mixing 20 drops of water with 10 drops of a tooth coloring solution, placing the mixture in the mouth for 1 minute, spitting out, lightly brushing with water, and evaluating according to the following criteria.

Before the experiment, After 14 days, Decrease (%) Example 1 2.45 ± 0.35 2.12 ± 0.29 13.42 Example 2 2.47 ± 0.32 2.15 + 0.33 13.14 Example 3 2.50 + - 0.34 2.19 + - 0.47 13.04 Example 4 2.46 ± 0.24 2.19 ± 0.24 11.05 Example 5 2.49 ± 0.49 2.21 ± 0.40 11.05 Comparative Example 1 2.59 ± 0.27 2.16 ± 0.36 16.97 Comparative Example 2 2.52 ± 0.19 2.14 ± 0.51 15.78 Rating index
0 = If there is no bacteria membrane
1 = If there is a bacterial membrane in the puncture of the gingival margin
2 = If there is a bacterial membrane on the gingival streak with a clear line
3 = When there is a bacteria membrane on the tooth surface by 1/3 of the cervical portion side
4 = When there is a bacterial membrane on the tooth surface by 2/3 of cervical side
5 = more than 2/3 of cervical side

As shown in Table 3, it can be seen that the compositions of Examples and Comparative Examples have the effect of removing plaque. In addition, it can be seen that the flags of Comparative Examples 1 and 2 are more effective than those of Examples 1 to 5. Taking into account the results shown in Table 2, it can be seen that Comparative Examples 1 and 2 have higher tooth wear than Examples 1 to 5, and thus the effect of removing plaque is high.

On the other hand, when comparing Examples 1 to 5, it can be seen that Example 1 has the greatest removal effect of the prage, and the effects of removing the prage of Examples 4 and 5 are relatively low. Considering the results shown in Table 2, it can be seen that Example 1 exhibited a higher effect of removing plaque than Examples 2 to 5, but the tooth wear was excessively large.

Comparing Examples 2 to 5, it can be seen that Examples 2 and 3 are superior to Examples 4 and 5 in removing plaque. In Examples 2 to 5, the components contained in the natural powders are different. In Examples 2 and 3, the natural powders include both the raw cores and the rice straw. In Examples 4 and 5, the natural powders contain no rice bran or straw . That is, when the composition for oral cleaning contains both rice bran and rice straw, the effect of removing prage is excellent.

Test Example 3. Antibacterial effect of composition for oral cleaning

In order to examine the antimicrobial activity against the causative bacteria of periodontal disease and tooth decay in the oral cleaning compositions of the above Examples and Comparative Examples, MICs of the respective bacteria were measured and the results are shown in Table 4 below.

Streptococcus mutans KCTC 3065 and Streptococcus sanguis KCTC 3284 were used as the cariogenic bacteria used in Test Example 3 of the present invention, and Actionbacilus Actinomycetemcomitans ATCC 29522 and Fusobacterium nucleatum ATCC 25586 were used as pathogenic bacteria for periodontal disease. The periodontal pathogens were cultured in BHI (Brain Heart Infusion) agar for 5 days at 37 ℃ and 5% CO _{2. The} cariogenic bacteria were cultured on BHI (Brain Heart Infusion) agar for 2 days under aerobic condition at 37 ℃.

The compositions for oral cleaning of the examples and comparative examples were each diluted 50 times and plated on a fresh medium. The culture medium of each of the cultivated microorganisms was inoculated and cultured at 37 ° C. for 24 hours. And measured at 600 nm with a microplate reader. The measured values were compared with the absorbance values of the control group (no treatment for oral cleaning composition), and the minimum concentration inhibiting the growth of the bacteria was evaluated by the minimum inhibitory concentration (MIC, mg / ml).

Streptococcus mutans Streptococcus sanguis Actionbacilus Actinomycetemcomitans Fusobacterium nucleatum MIC (mg /) MIC (mg /) MIC (mg /) MIC (mg /) Example 1 6 6 7 7 Example 2 6 7 6 6 Example 3 8 9 8 8 Example 4 10 11 12 12 Example 5 11 12 14 13 Comparative Example 1 21 25 24 29 Comparative Example 2 23 27 29 30

As shown in Table 4, it can be seen that Examples 1 to 5 suppress the growth of causative bacteria and periodontal disease causing bacteria at lower concentrations than Comparative Examples 1 and 2.

Comparing Examples 1 and 2, it can be seen that the growth inhibitory concentrations of the causative bacteria of the present invention and periodontal disease causing bacteria of Examples 1 and 2 are similar. In Examples 1 and 2, the kinds and contents of the components are the same, and the particle sizes of the natural powders are different, and the particle size of the natural powders does not affect the growth inhibition of the bacteria. In addition, considering the results of Tables 2 and 3, the composition for oral cleaning having a particle size of 20 탆 of natural powder is superior to the composition for oral cleaning having a particle size of natural powder of 1 to 10 탆, , The antimicrobial effect was similar to the causative bacteria of periodontal disease and periodontal disease, and the tooth was damaged due to high wear of teeth.

Comparing Examples 2 to 5, it can be seen that Example 2 has the best antimicrobial effect on the causative bacteria and periodontal disease causing bacteria, and the antibacterial effect of Example 5 is the lowest. In Examples 2 to 5, components contained in the natural powder are different, Examples 2 and 3 include rice bran and rice straw, but Example 4 does not include rice straw, and Example 5 does not include rice bran . That is, when the composition for oral cleaning contains both rice bran and rice straw, it can be seen that the antimicrobial effect against the causative bacteria and periodontal disease causative bacteria is excellent, and the activity of causative bacteria and periodontal disease bacteria is inhibited, It can be seen that it is effective in the improvement of periodontal disease.

Test Example 4. Evaluation of bad breath suppression effect and feeling of use of composition for oral cleaning

In order to confirm the suppression of bad breath and the feeling of use of the compositions for oral cleansing of the above-mentioned Examples and Comparative Examples, 70 adults without oral diseases and other diseases that could affect the experiment were selected and the oral cleaning compositions of Examples and Comparative Examples And the results are shown in Table 5 below.

In the measurement of halitosis, the subjects were stopped for 24 hours before the experiment, and the halitosis was measured with a halimeter, and a total of 10 persons with similar halitosis receipts were measured for a total of 14 days, three times a day A composition for oral cleaning was used. The degree of halitosis was measured with a Harley meter at the point of time before the experiment, 7 days, and 14 days, and the reduction effect of halitosis according to the period of use of the oral cleaning composition is shown in Table 5 below.

After using for 14 days, feelings were evaluated on a 5 - point scale through questionnaires.

Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Halitosis suppression Immediately after the experiment 217 221 219 214 213 216 222 After 7 days 164 170 178 177 178 184 189 After 14 days 128 131 148 145 146 164 171 Decrease rate after 14 days (%) 41.0 40.7 32.4 32.2 31.5 24.1 23.0 Feeling Irritability 3 5 5 5 5 2 2 Bubble power 3 4 4 4 4 4 4 Overall satisfaction 3 5 5 5 5 3 3 Usability evaluation criteria
1 point: very dissatisfied, 2 points: unsatisfied, 3 points: average, 4 points: satisfaction, 5 points: very satisfied

As shown in Table 5, it can be seen that Examples 1 to 5 have a higher rate of halitosis reduction than Comparative Examples 1 and 2. That is, in Examples 1 to 5, it was found that the oral care cleansing composition contained natural powder, and the odor was significantly reduced.

Comparing Examples 1 to 5, it can be seen that Examples 1 and 2 are excellent in the effect of suppressing bad breath. In Examples 1 to 2, all of the rice bran, rice straw and millet were included, while Examples 3 to 5 did not include any of rice bran, rice straw and millet, and the oral cleaning composition according to the present invention contained rice bran, rice straw And the badge were all included, it was found that the effect of suppressing bad breath was excellent.

In comparison with the feeling of use, it can be seen that Example 1 has more irritation than Examples 2 to 5, and overall satisfaction is lower. This is considered to be because the particles of the natural powder included in Example 1 exhibit a foreign body sensation and give a stimulus to the teeth and oral cavity, resulting in low satisfaction.

Claims (5)

Natural powder, magnesium carbonate, glycerin, gum arabic, xylitol, apple wash, essential oil, grapefruit seed extract, dental silica, propolis and solvent,
Wherein the natural powder is pulverized and used in a ratio of 3: 6: 1: 1 to 3: 1 by weight of rice bran, rice straw and millet. The method according to claim 1,
Wherein the oral cleaning composition comprises 5 to 40 wt% of natural powder, 5 to 20 wt% of magnesium carbonate, 10 to 20 wt% of glycerin, 10 to 20 wt% of gum arabic, 3 to 10 wt% of xylitol, 10 to 20 wt% Characterized in that the composition comprises 0.5 to 2% by weight of essential oils, 1 to 2% by weight of grapefruit seed extract, 5 to 10% by weight of dental silica, 1 to 2% by weight of propolis and 3 to 5% / RTI > delete 3. The method according to claim 1 or 2,
Wherein the natural powder has a particle size of 1 to 10 mu m. 3. The method according to claim 1 or 2,
Wherein the solvent comprises at least one selected from the group consisting of purified water and ethanol.