KR20230153847A - Antibacterial toothpaste composition with excellent effect of preventing gum disease and removing bad breath - Google Patents

Abstract

The present invention relates to an antibacterial toothpaste composition that is effective in preventing gum disease and removing bad breath.
An antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects according to an embodiment of the technical idea of the present invention includes silicon dioxide, sodium monofluorophospate, tocopheryl acetate, and sorbitol solution ( Sorbitol, Hydrated Silica, Carboxymethyl Cellulose Sodium (Cellulose Gum), xylitol, stevioside, ascorbic acid, L-menthol, propolis extract extract), sage extract (salvia officinalis (sage) extract), rosemary extract (rosmarinus officinalis (rosemary) extract), Centella asiatica extract, green tea extract (camellia sinensis leaf extract), combined flavor (water-soluble mastic gum) (Pistacia lentiscus (mastic) gum), ginseng extract (panax ginseng root extract), eucalyptus globulus leaf oil, spearmint oil, flavor and purified water.
With the above configuration, the toothpaste composition according to an embodiment of the technical idea of the present invention has the effect of cleaning teeth and removing bad breath without using ingredients that may be harmful to the human body, such as synthetic surfactants, as well as gum diseases such as periodontitis and gingivitis. It has excellent efficacy and can promote oral health.

Description

Antibacterial toothpaste composition that is effective in preventing gum disease and removing bad breath {ANTIBACTERIAL TOOTHPASTE COMPOSITION WITH EXCELLENT EFFECT OF PREVENTING GUM DISEASE AND REMOVING BAD BREATH}

The present invention relates to an antibacterial toothpaste composition that is excellent in preventing gum disease and removing bad breath. More specifically, it relates to an antibacterial toothpaste composition that is effective in cleaning teeth and removing bad breath without using ingredients that may be harmful to the human body such as synthetic surfactants, as well as in periodontitis and gingivitis. This relates to an antibacterial toothpaste composition that is effective in preventing gum disease and eliminating bad breath, which can promote oral health by demonstrating excellent efficacy against gum disease.

In general, bad breath is caused by an acquired systemic disease or when proteins and food residues in saliva are decomposed by microorganisms and amino acids produced are decomposed by deoxidation enzymes or amino enzymes to produce substances that cause bad odor. , Among these, the bad breath that occurs when sulfides contained in substances such as garlic or pepper are decomposed is known to be very disgusting.

Representative ingredients that cause bad breath include Volatile Sulfide Compounds (hereinafter abbreviated as VSC). These volatile sulfides include Hydrogen sulfide (H ₂ S) and Methyl mercaptan (CH ₃₎ . SH), dimethyl mercaptan, (CH ₃ ) ₂ S], etc., and in particular, methyl mercaptan is known to be the main component of the disgusting smell of bad breath. In addition, in the case of fish, as the freshness decreases, fishy smell such as trimethyl amine ((CH ₃ ) ₃ N) or δ-aminovaleric acid is formed, and these volatile amine compounds, especially, Trimethylamine forms a major part of the odor component. Other substances that cause bad breath include aldehydes, fatty acids, ammonia, or pyridine.

Stomatitis refers to all inflammatory lesions that appear in the oral cavity, including the lips, mouth, tongue, and inside the cheeks. It usually appears as a white depression, and once it occurs, it is accompanied by symptoms such as bad breath, blisters, and ulcers, and the pain is so severe that it is often difficult to even chew or swallow food. Stomatitis usually occurs more often in the summer.

Additionally, periodontal disease, including gingivitis and periodontal disease, is an inflammatory condition of the tooth-supporting tissue caused by bacteria, and is a disease that results in tooth loss due to bleeding, formation of periodontal pockets, and destruction of alveolar bone. This periodontal disease progresses through the process of bacterial colonization, bacterial invasion of periodontal tissue, and destruction of periodontal tissue.

Specifically, due to poor oral hygiene, oral bacteria form a bacterial film that causes inflammation, which sometimes causes the gums to bleed and bad breath. If this condition progresses further, the gaps between the teeth and gums become deeper, forming periodontal pockets. , bacteria that cause periodontal disease multiply here, resulting in periodontitis.

Conventionally, bad breath is removed by brushing the teeth using a general toothpaste composition to remove foreign substances in the mouth, or by using fluorine compounds such as sodium fluoride and sodium monofluorophosphate or oral antibacterial agents such as triclosan and chlorohexadine hydrochloride, which cause bad breath. It has been used to prevent or suppress bad breath by removing .

However, the method of removing foreign substances in the oral cavity by brushing using general toothpaste compositions can prevent and suppress bad breath in the short term, but the effect cannot be maintained for a long time. Triclosan, chlorohexadine hydrochloride, sodium fluoride and monofluorophosphate Sodium is a chemically synthesized product and cannot be said to be an environmentally friendly product.

In addition, when excessive use of fluorine compounds such as sodium fluoride and sodium monofluorophosphate has side effects such as tooth decay, the Food and Drug Safety Administration stipulates that the fluorine content that can be contained in toothpaste compositions is 1000 ppm or less.

In addition, bad breath removal ingredients applied to the oral cavity can enter the body or flow into the gastrointestinal tract through the oral mucosa, so it is necessary to use substances that are harmless to the human body, and when applied to products because the effect of continuously suppressing oral bacteria is weak. It has problems such as poor effectiveness in preventing and treating periodontal disease, preventing cavities, and removing bad breath, and is not very usable.

Domestic Registered Patent No. 10-1992927 (registered on June 19, 2019) Domestic registered patent No. 10-1250567 (registered on March 28, 2013) Domestic Registered Patent No. 10-2299387 (registered on September 1, 2021)

The problem that the present invention aims to solve is to promote oral health by cleaning teeth and removing bad breath, without using ingredients that may be harmful to the human body, such as synthetic surfactants, and by demonstrating excellent efficacy against gum diseases such as periodontitis and gingivitis. The goal is to provide an antibacterial toothpaste composition that is effective in preventing gum disease and eliminating bad breath.

In addition, another problem that the present invention aims to solve is the prevention of gum disease, which does not use surfactants that create foam, so only fine foam is generated by toothbrushing, so that you can feel a cleaner, refreshed feeling without any residue left in the mouth after brushing your teeth. The aim is to provide an antibacterial toothpaste composition with excellent bad breath removal effect.

In addition, another problem to be solved by the present invention is to provide an antibacterial toothpaste composition that is excellent in preventing gum disease and removing bad breath, which can remove even fine plaque, provide a refreshing feeling after brushing teeth, and improve whitening function.

The various problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

An antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects according to an embodiment of the technical idea of the present invention includes silicon dioxide, sodium monofluorophospate, tocopheryl acetate, and sorbitol solution ( Sorbitol, Hydrated Silica, Carboxymethyl Cellulose Sodium (Cellulose Gum), xylitol, stevioside, ascorbic acid, L-menthol, propolis extract extract), sage extract (salvia officinalis (sage) extract), rosemary extract (rosmarinus officinalis (rosemary) extract), Centella asiatica extract, green tea extract (camellia sinensis leaf extract), combined flavor (water-soluble mastic gum) (Pistacia lentiscus (mastic) gum), ginseng extract (panax ginseng root extract), eucalyptus globulus leaf oil, spearmint oil, flavor and purified water.

5 to 7 parts by weight of silicon dioxide, 0.5 to 1 part by weight of sodium monofluorophospate, 0.05 to 0.25 parts by weight of tocopheryl acetate, 60 to 70 parts by weight of sorbitol, water 8 to 12 parts by weight of Hydrated Silica, 0.1 to 0.3 parts by weight of sodium carboxymethyl cellulose (Cellulose Gum), 5 to 10 parts by weight of xylitol, 0.05 to 0.15 parts by weight of stevioside, ascorbic acid ( ascorbic acid) 0.0005 to 0.0015 parts by weight, L-menthol (menthol) 0.2 to 0.6 parts by weight, propolis extract (propolis extract) 0.0005 to 0.0015 parts by weight, sage extract (salvia officinalis (sage) extract) 0.005 to 0.015 parts by weight, Rosemary extract (rosmarinus officinalis (rosemary) extract) 0.0005 to 0.0015 parts by weight, Centella asiatica extract (Centella asiatica extract) 0.0005 to 0.0015 parts by weight, green tea extract (camellia sinensis leaf extract) 0.005 to 0.015 parts by weight, combined flavor (water-soluble mastic gum) ) (Pistacia lentiscus (mastic) gum) 0.0005 to 0.0015 parts by weight, ginseng extract (panax ginseng root extract) 0.005 to 0.015 parts by weight, eucalyptus oil (eucalyptus globulus leaf oil) 0.0005 to 0.0015 parts by weight, spearmint oil It may be included in a weight ratio of 0.1 to 0.9 parts by weight, 0.1 to 0.9 parts by weight of flavor, and 8 to 12 parts by weight of purified water.

Specific details of other embodiments are included in the detailed description.

The toothpaste composition according to an embodiment of the technical idea of the present invention exhibits excellent efficacy against gum diseases such as periodontitis and gingivitis in addition to teeth cleaning and bad breath removal effects without using ingredients that may be harmful to the human body, such as synthetic surfactants. This can promote oral health.

In addition, the toothpaste composition according to an embodiment of the technical idea of the present invention does not use a surfactant that creates foam, so only fine foam is generated by brushing the teeth, so you can feel a cleaner, more refreshed feeling without any residue remaining in your mouth after brushing your teeth. there is.

In addition, the toothpaste composition according to an embodiment of the technical idea of the present invention has an antibacterial effect and removes even fine plaque, thereby providing a refreshing feeling after brushing teeth and improving whitening function.

It will be fully understood that embodiments of the technical idea of the present invention can provide various effects that are not specifically mentioned.

Figure 1 is a test report showing the results of a sterilization test of toothpaste according to an example.
Figure 2 is a confirmation of whether toothpaste according to an example contains harmful ingredients.

The advantages and features of the present invention, and methods for achieving them, will become clear with reference to the embodiments described in detail below. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosure will be thorough and complete and so that the spirit of the invention can be sufficiently conveyed to those skilled in the art.

The terms used in this application are only used to describe specific embodiments and are not intended to limit the invention. Singular expressions include plural expressions unless the context clearly dictates otherwise.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as generally understood by a person of ordinary skill in the technical field to which the present invention pertains. Terms defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related technology, and should not be interpreted as having an ideal or excessively formal meaning unless explicitly defined in the present application. No.

Hereinafter, an antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects according to an embodiment of the technical idea of the present invention will be described in detail with preferred examples.

An antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects according to an embodiment of the technical idea of the present invention includes silicon dioxide, sodium monofluorophospate, tocopheryl acetate, and sorbitol solution ( 70% amorphous) (Sorbitol), Hydrated Silica, Carboxymethyl Cellulose Sodium (Cellulose Gum), xylitol, stevioside, ascorbic acid, L-menthol , propolis extract, sage extract (salvia officinalis (sage) extract), rosemary extract (rosmarinus officinalis (rosemary) extract), centella asiatica extract, green tea extract (camellia sinensis leaf extract), combined fragrance (Water-soluble mastic gum) (Pistacia lentiscus (mastic) gum), ginseng extract (panax ginseng root extract), eucalyptus globulus leaf oil, spearmint oil, flavor and purified water. Includes.

In addition, the toothpaste composition according to the present invention includes 5 to 7 parts by weight of silicon dioxide, 0.5 to 1 part by weight of sodium monofluorophospate, 0.05 to 0.25 parts by weight of tocopheryl acetate, and sorbitol solution (70 parts by weight) % amorphous) (Sorbitol) 60 to 70 parts by weight, Hydrated Silica (8 to 12 parts by weight), Carboxymethyl Cellulose Sodium (Cellulose Gum) 0.1 to 0.3 parts by weight, xylitol (xylitol) 5 to 10 parts by weight, Stem 0.05 to 0.15 parts by weight of stevioside, 0.0005 to 0.0015 parts by weight of ascorbic acid, 0.2 to 0.6 parts by weight of L-menthol, 0.0005 to 0.0015 parts by weight of propolis extract, sage extract (salvia officinalis (sage) extract) 0.005 to 0.015 parts by weight, rosemary extract (rosmarinus officinalis (rosemary) extract) 0.0005 to 0.0015 parts by weight, Centella asiatica extract (Centella asiatica extract) 0.0005 to 0.0015 parts by weight, green tea extract (camellia sinensis leaf extract) ) 0.005 to 0.015 parts by weight, combined fragrance (water-soluble mastic gum) 0.0005 to 0.0015 parts by weight, 0.005 to 0.015 parts by weight of ginseng extract (panax ginseng root extract), eucalyptus globulus leaf oil ) It may be included in a weight ratio of 0.0005 to 0.0015 parts by weight, 0.1 to 0.9 parts by weight of spearmint oil, 0.1 to 0.9 parts by weight of flavor, and 8 to 12 parts by weight of purified water.

The silicon dioxide (Silica) is a high-quality abrasive with fine, soft, and round particles. It reduces tooth damage and is delicately polished to minimize wear on the enamel layer that protects the teeth. In addition, it can ensure the shelf life of the toothpaste composition, protect it from the effects of moisture, and help the ingredients flow smoothly without sticking to each other.

The silicon dioxide can perform a plaque removal (anti-plaque) function. The crystal structure of the silicon dioxide itself is round, unlike precipitated carbonate, so it minimizes polishing of teeth and removes foreign substances adsorbed between teeth and on the tooth surface. It can remove plaque (anti-plaque) and provide a whitening effect at the same time.

The sodium monofluorophospate can play a role in preventing cavities by supplying fluoride to the surface of teeth. In addition, it prevents oral bacteria from dissolving tooth enamel due to corrosive acid, strengthens teeth by promoting calcium supply, and supplies fluoride to the surface of teeth to increase tooth acid resistance and prevent cavities. .

Tocopheryl Acetate is also called vitamin E and is a nutrient related to the health of gum epithelial tissue. Vitamin E is a fat-soluble vitamin composed of a total of eight types, and it is famous for the fact that vitamin E acts as an antioxidant in the body.

In addition, the tocopheryl acetate prevents peroxidation of lipids that make up the cell membrane, strengthens the cell membrane and gums, and has an anti-inflammatory effect that prevents gingivitis and periodontitis by suppressing inflammatory factors. . In addition, it enters the cholesterol particles and prevents blood clots, which helps heal inflammation by improving blood circulation to the gums.

The sorbitol solution (70% amorphous) (Sorbitol) acts as a humectant to reduce dryness of the mouth and can help prevent the mouth from drying out after brushing teeth.

The hydrated silica is a soft abrasive and can be used for mechanical cleaning of teeth.

The carboxymethyl cellulose sodium (Cellulose Gum) is used as a viscosity regulator and stabilizer for lotions, emulsions, and creams by utilizing the high viscosity of aqueous solutions, and is used as an emulsification and dispersion stability agent in emulsions, creams, and emulsified foundations by using protective colloids and viscosity. It is formulated for the purpose of improvement. In particular, by using the carboxymethyl cellulose sodium (Cellulose Gum), safety can be further improved in that the amount of surfactant used can be reduced and it has the effect of alleviating irritation.

The xylitol is a new natural sweetener that does not form acids that cause cavities, and can treat gum disease, periodontal disease, and gum convergence.

Xylitol is a natural sweetener verified by the WHO and FDA that prevents mutans bacteria and promotes salivary secretion in the oral cavity. Saliva contains dissolved calcium components essential for tooth restoration, so the smoother salivary secretion, the more inhibited cavities are. It has an anti-cavity function that suppresses cavities by inducing smooth saliva secretion and also functions to prevent cavities bacteria.

The steviol glycoside (stevioside) is a compound that gives the sweet taste of stevia leaves, a South American plant belonging to the Asteraceae family, and is the main ingredient of many sweeteners marketed under the common name stevia and various trade names. Stevia has 200 to 300 times the sugar content of sugar, so it is used as a natural sweetener that can replace sugar.

Ascorbic acid, also called vitamin C, is a nutrient contained in fruit sugar, vegetables, and proteins and is an essential antioxidant component in the body.

In addition, it is water-soluble and soluble in water, has an antioxidant effect that delays aging by helping to form connective tissue and support tissue in the skin, and not only whitens, but also helps collagen formation to make the skin more elastic.

The L-menthol (menthol) is a major component of peppermint oil and peppermint oil obtained from spearmint (Mentha piperita and Mentha arvenisis). It helps relieve itching through anti-inflammatory action and has a refreshing feeling and cooling function to lower temperature.

The propolis extract is a natural antibacterial substance that performs antioxidant and antibacterial activities in the oral cavity, and has antibacterial and antiviral anti-inflammatory effects, helping to manage free radicals.

The propolis extract is a glue-like substance made by bees by mixing their own saliva with ingredients collected from the buds and bark of poplar trees, eucalyptus trees, pine trees, etc., and the medicinal ingredients of various plants such as yeast, wax, and bee saliva. This is a mixed substance. In particular, the component called flavonoid contained in this raw material has anti-inflammatory and antibacterial properties.

The sage extract (salvia officinalis (sage) extract) can be extracted from sage, which is a medicinal plant that has long been widely known as a panacea. The sage is used by drying the leaves. In addition to its tonic effect, it has excellent medicinal effects on the nervous system and digestive system, and has sterilizing and disinfecting effects such as preservative, antibacterial, and anti-inflammatory, so it is also used as an anti-inflammatory agent for various inflammations.

The rosemary extract (rosmarinus officinalis (rosemary) extract) is one of the representative medicinal plants, and has excellent pain relief, antibacterial, and sterilizing effects as well as excellent moisturizing effects. It is used as a cosmetic ingredient as it gently soothes the skin, and its unique fresh scent activates brain function, so it is often used as a spice and is also helpful for skin care and removing bad breath.

The Centella asiatica extract can be extracted from Centella asiatica, and it has been discovered that the ingredient called madecassic acid in the leaves and stems of Centella asiatica has the power to relieve inflammation and heal wounds such as tumors and ulcers. It is also widely used as a raw material for ointments, toothpaste, and cosmetics.

Centella asiatica extract is an extract of Centella asiatica leaves that is used for wound healing and antioxidant effects. It has skin regeneration, antibacterial, anti-inflammatory, antioxidant, and skin tone improvement effects, helps prevent skin aging, relieves troubles, and has a disinfecting effect. Improves scars and improves elasticity.

The green tea extract (camellia sinensis leaf extract) is rich in antioxidants and nutrients, strengthens immunity and prevents various diseases, and is rich in antioxidants, preventing chronic diseases and preventing skin aging.

In Oriental medicine, green tea has been used to protect teeth, and green tea can be used not only for teeth but also when there is an infection in the mouth or to eliminate bad breath.

The green tea extract is rich in antioxidants, which protects teeth from bacteria and reduces inflammation. The catechin component prevents cell damage and inhibits the formation of free radicals that cause aging, protecting cells from damage.

Mastic gum, which is the combined flavoring agent (water-soluble mastic gum) (Pistacia lentiscus (mastic) gum), is made by collecting the sticky liquid sap of the mastic tree that grows only on the island of Chios in the Aegean Sea in Greece, then drying and hardening it. , The shape of the sap flowing out resembles tears, so it is called “God’s tears” or “God’s tears.”

The above combined flavoring agent (water-soluble mastic gum) (Pistacia lentiscus (mastic) gum) is recognized as an individually approved raw material by the Food and Drug Administration in countries around the world, including the United States and Japan, and is an antioxidant that inhibits the synthesis of enzymes that cause inflammation in the body and removes free radicals. It is famous for its effectiveness.

In addition, it is known as one of the world's top three natural anti-inflammatory substances, on par with xylitol and propolis. The Greeks chew mastic like gum to relieve symptoms of indigestion, stomach pain, and gastric ulcers, ingesting only the sap extract, and then consuming the contents. It is spit out and has an excellent anti-inflammatory effect that suppresses bacteria in the mouth, so it is used as the main ingredient in toothpaste and mouthwash.

The ginseng extract (panax ginseng root extract) can be extracted from ginseng, which restores vitality and is used for physical weakness, boredom, fatigue, loss of appetite, vomiting, and diarrhea, helps lung function, produces essence, and has ocular and renal effects. Increases renal function. Pharmacological effects have been reported to include cerebral cortex excitement and inhibition, balance, anti-fatigue, anti-aging, immune enhancement, cardiac contraction, gonadotropism, hyperglycemia suppression, protein synthesis promotion, homeostasis maintenance, anti-cancer, and detoxification.

The eucalyptus globulus leaf oil can be extracted from eucalyptus, which is one of the most useful trees in the world. Australian indigenous people used crushed eucalyptus leaves for minor wounds and fungal infections, and used it for respiratory diseases such as bronchitis and cough. Leaves and oil were used. After eucalyptus was introduced to Europe in 1852, it was used in Western medicine and herbal medicine to treat infections such as malaria, cholera, and typhoid fever, and asthma. Its strong sterilizing and antibacterial effects were scientifically proven to treat respiratory symptoms such as sore throat, bronchitis, and colds. It is widely used to prevent infectious diseases and as a disinfectant. Today, it is also used as the main ingredient in mouthwash, gargle, toothpaste, and pain reliever ointment.

The eucalyptus is used to treat wounds and relieve infection, inflammation and pain, and has anti-inflammatory, antibacterial and antioxidant effects, and is helpful for skin beauty and anti-aging. It is effective in preventing cavities by suppressing bacterial growth, helps improve various inflammatory oral diseases, and helps relieve bad breath through its sterilizing and disinfecting effect.

The spearmint oil can be manufactured from spearmint. Spearmint, which is native to Europe, is considered one of the three major mints along with apple mint and peppermint among the numerous mints.

The spearmint refreshes the mood and has a sweet and strong mint flavor, so it is mainly used as a flavoring for toothpaste, gum, candy, and mouthwash, and is used to obtain a soothing and analgesic effect. It soothes stuffy noses, headaches, etc., and has a cool scent to relieve bad breath. It helps relieve stress, and is also used for oral hygiene, gum ulcer treatment, and teeth whitening. It is also used as a flavoring agent in mouthwash to help eliminate bad breath.

The flavor is a flavoring agent and can be used to remove bad breath.

The above-described fragrance may include various types of fragrance known in the art. For convenience of explanation and clarity of the technical idea of the present invention, detailed description thereof will be omitted.

The purified water can be used as a solvent to mix the composition.

For example, the purified water may be ionized water or magnetized water that has been magnetized. For example, the magnetized water is split into small pieces by applying a magnetic force to the water, improving its absorption into the human body and its penetration power. As it becomes stronger, the permeability of the composition can be improved.

Hereinafter, with reference to the attached drawings, an antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects according to an embodiment of the technical idea of the present invention will be described in more detail through examples and comparative examples.

<Example>

6 parts by weight of silicon dioxide, 0.74 parts by weight of sodium monofluorophosphate, 0.18 parts by weight of tocopherol acetate, 64 parts by weight of sorbitol solution, 10 parts by weight of hydrous silicic acid, 0.2 parts by weight of sodium carboxymethyl cellulose, 7 parts by weight of xylitol, 0.1 parts by weight of steviol glycoside parts, ascorbic acid 0.001 parts by weight, L-menthol 0.4 parts by weight, propolis extract 0.001 parts by weight, sage extract 0.01 parts by weight, rosemary extract 0.001 parts by weight, centella asiatica extract 0.001 parts by weight, green tea extract 0.01 parts by weight, combined flavor (water soluble) Toothpaste was prepared by mixing a composition consisting of 0.001 parts by weight of mastic gum, 0.01 parts by weight of ginseng extract, 0.001 parts by weight of eucalyptus oil, 0.5 parts by weight of spearmint oil, 0.5 parts by weight of fragrance, and 10.344 parts by weight of purified water.

<Comparative example>

A commercially available toothpaste (manufactured by L Company) was purchased and used as the toothpaste according to the comparative example.

1. Sterilization test

A sterilization test of the toothpaste according to the example was performed.

Figure 1 is a test report showing the results of a sterilization test of toothpaste according to an example.

Referring to Figure 1, it can be seen that the toothpaste according to the example performed using the test strain S. mutans ATCC 25175 has excellent sterilizing and antibacterial properties by reducing oral bacteria and mutans bacteria, which cause cavities, by more than 97%.

2. Test to check whether harmful ingredients are included

It was confirmed whether the toothpaste according to the example contained harmful ingredients such as synthetic surfactants.

Figure 2 is a confirmation of whether toothpaste according to an example contains harmful ingredients.

Referring to Figure 2, the toothpaste according to the example contains harmful ingredients such as synthetic surfactants, parabens, MIT, CMIT, artificial colors, artificial emulsifiers, PEG, benzoic acids, sodium benzoate, mineral oil, microplastics, saccharin, and synthetic preservatives. You can confirm that it is a safe and eco-friendly toothpaste that does not contain any ingredients.

3. PCR and measurement of RDA

In order to determine the cleaning ability and polishing power of the toothpaste prepared in Examples and Comparative Examples, the toothpaste prepared in Examples and Comparative Examples was tested for the typical fat film cleaning ratio (PCR, Pellicle Cleaning Ratio) and radioactive dentin polishing ( RDA (Radioactive Dentine Abrasivity) values were measured, and the results are shown in [Table 1] below.

division PCR RDA Example 159 92 Comparative example 145 86

Referring to [Table 1], the toothpaste according to the example showed higher PCR and RDA values than the toothpaste according to the comparative example. Therefore, it was confirmed that the toothpaste according to the example had an excellent plaque removal effect.

4. MIC measurement

MIC measurements were performed to determine the antibacterial effect of toothpastes prepared according to Examples and Comparative Examples against caries bacteria and periodontal disease-causing bacteria.

Brain heart infusion agar (BHIA) containing CPC at different concentrations was used to evaluate antibacterial activity using the agar dilution method.

In the case of periodontal disease-causing bacteria, the bacteria were cultured for 6 days at 35°C and 6% _CO2 , and in the case of cavity-causing bacteria, the minimum concentration that inhibits bacterial growth was determined after culturing for 3 days at 35°C and aerobic conditions (minimum growth inhibitory concentration). MIC) was determined.

In addition, the antibacterial activity was evaluated using BHIA containing the Examples and Comparative Examples at different concentrations by the agar medium dilution method. The test concentration was performed at a total of 10 levels of dilution, starting from 50 times the dilution of the test toothpaste and diluting it 2 times at a time, and the results are shown in [Table 2] below.

(1) Test bacteria

Periodontal disease-causing bacteria: Actionbacilus Actinomycetemcomitans ATCC 29522, Fusobacterium nucleatum ATCC 25586

Cavity-causing bacteria: Actinomyces viscosus ATCC 158987

(2) Medium used

Blood agar medium (blood agar base + sheep blood at final concentration 5%) BHI agar

division A Actinomycetemcomitans F nucleatum Actinomyces viscosus MIC 8.8 4.5 3.3 Example 235 680 1150 Comparative example 219 625 1080

Referring to [Table 2], the MIC for antibacterial activity against each test bacteria was found to be 3.3 to 8.8 μg/mL, and it was found that the toothpaste of the example had superior antibacterial activity compared to the toothpaste of the comparative example.

5. Bad breath removal effect of toothpaste composition

In order to determine the effectiveness of toothpaste in removing bad breath, 35 people (17 men: 18 women) who were aware of having bad breath on a regular basis were asked to eat the same meal, and then the degree of bad breath was measured using a standard Halimeta. was quantified.

The difference in Halimeta levels before and after brushing was determined and the average value was measured, and the results are shown in [Table 3] below.

division Difference in value before and after enshrining Example 265 Comparative example 240

Referring to [Table 3], it was confirmed that the toothpaste prepared according to the example had an excellent bad breath effect compared to the toothpaste prepared according to the comparative example.

6. Whitening effect measurement experiment

The measurement method was to measure the whitening effect by having subjects use the examples and comparative examples as toothpaste for 4 months. After selecting 50 test subjects and measuring their color tone with a color scale (Trubyte Bioform) in advance, they were divided into 5 groups of 10 people each with almost the same average color value (10 example users and 10 comparative example users), and each was given a test. The toothpastes of Examples and Comparative Examples were distributed and used.

In order to confirm the increase in the brightness of teeth, 10 types that are easy to distinguish sensory-wise are selected among the 24 standard standards for brightness in the Trubyte Bioform color scale, and the brightness value for each is set to a minimum of 1. Evaluation scores were given up to a maximum of 10 points. Before using each toothpaste, the brightness value of the teeth in each group was evaluated to the first decimal place based on the above standards, and the brightness value after brushing for 4 months was evaluated.

division Average brightness value (before experiment) Average brightness value (after 3 months) Example 3.8 6.3 Comparative example 3.6 6.0

Referring to [Table 4], the brightness value of the toothpaste according to the example increased compared to the toothpaste according to the comparative example, through which it was confirmed that the toothpaste according to the example had excellent teeth whitening and tartar removal effects.

7. Sensory evaluation of feeling of use

After using the toothpaste according to the examples and comparative examples for 4 weeks, satisfaction with the feeling of use, such as foaming power, dry mouth after use, irritation, and refreshment, was evaluated on a 5-point scale, and then a sensory evaluation was performed using the average value. , the results are shown in [Table 5] below.

The standard of satisfaction with the feeling of use was evaluated on a 5-point scale.

(1 point: very dissatisfied, 2 points: dissatisfied, 3 points: average, 4 points: satisfied, 5 points: very satisfied)

division foam power Dry mouth after use irritation refreshing Example 3.3 4.8 4.7 4.7 Comparative example 4.5 3.9 4.1 4.3

Referring to [Table 5], it can be seen that the toothpaste according to the example does not contain synthetic surfactants, so it generates less foam, but after use, dry mouth is less, it is not irritating, and you can feel refreshed and refreshed. there is.

Although a preferred embodiment of the present invention has been described above, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing the technical idea or essential features. You will be able to. Therefore, the embodiment described above should be understood as illustrative in all respects and not restrictive.

Claims (2)

Silicon dioxide, Sodium Monofluorophospate, Tocopheryl Acetate, Sorbitol, Hydrated Silica, Sodium Carboxymethyl Cellulose (Cellulose Gum), Xylitol, Stem stevioside, ascorbic acid, L-menthol, propolis extract, salvia officinalis (sage) extract, rosmarinus officinalis (rosemary) extract, Centella asiatica extract, green tea extract (camellia sinensis leaf extract), combined fragrance (Pistacia lentiscus (mastic) gum), ginseng extract (panax ginseng root extract), eucalyptus globulus leaf oil ), an antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects, comprising spearmint oil, flavor, and purified water.
According to clause 1,
5 to 7 parts by weight of silicon dioxide, 0.5 to 1 part by weight of sodium monofluorophospate, 0.05 to 0.25 parts by weight of tocopheryl acetate, 60 to 70 parts by weight of sorbitol, water 8 to 12 parts by weight of Hydrated Silica, 0.1 to 0.3 parts by weight of sodium carboxymethyl cellulose (Cellulose Gum), 5 to 10 parts by weight of xylitol, 0.05 to 0.15 parts by weight of stevioside, ascorbic acid ( ascorbic acid) 0.0005 to 0.0015 parts by weight, L-menthol (menthol) 0.2 to 0.6 parts by weight, propolis extract (propolis extract) 0.0005 to 0.0015 parts by weight, sage extract (salvia officinalis (sage) extract) 0.005 to 0.015 parts by weight, Rosemary extract (rosmarinus officinalis (rosemary) extract) 0.0005 to 0.0015 parts by weight, Centella asiatica extract (Centella asiatica extract) 0.0005 to 0.0015 parts by weight, green tea extract (camellia sinensis leaf extract) 0.005 to 0.015 parts by weight, combined flavor (water-soluble mastic gum) ) (Pistacia lentiscus (mastic) gum) 0.0005 to 0.0015 parts by weight, ginseng extract (panax ginseng root extract) 0.005 to 0.015 parts by weight, eucalyptus oil (eucalyptus globulus leaf oil) 0.0005 to 0.0015 parts by weight, spearmint oil An antibacterial toothpaste composition with excellent gum disease prevention and bad breath removal effects, comprising 0.1 to 0.9 parts by weight of flavor, 0.1 to 0.9 parts by weight of flavor, and 8 to 12 parts by weight of purified water.