KR101250567B1 - Functional ToothPaste Composition - Google Patents

Abstract

The present invention excludes tar pigments, saccharin, parabens and artificial fragrances that are harmful to teeth, and fluorine content is less than 500 ppm, which is 1/2 of the existing toothpaste, and phytoncide, allantoin, aminocaproic acid, xylitol, It contains various medicinal ingredients such as green tea extract, grapefruit seed extract, bamboo salt, licorice extract, and red ginseng extract to supply effective ingredients to teeth and gums, and also to remove plaque (antifrag), prevent tartar deposition, and various gum diseases (gingivitis , Periodontitis, periodontal pustules) and high-functional, natural-friendly toothpaste .

Description

Toothpaste Composition {Functional ToothPaste Composition}

The present invention relates to a high-functional nature-friendly toothpaste composition, in particular, by adding a natural raw material that is environmentally friendly and beneficial to humans by eliminating harmful ingredients to the human body used in toothpaste, more functional and low-stimulating high-functional toothpaste composition It is about.

It is well known that existing toothpaste contains parabens (preservatives), saccharin (artificial sweeteners), artificial colors, tars, and fluorine.

The parahydroxybenzoic acid ester used in the existing toothpaste is not a single substance but is a generic name for a substance formed by reaction of parahydroxybenzoic acid ethyl alcohol, propyl alcohol, butyl alcohol, etc., and is also called 'paraben'.

Although these substances vary slightly from substance to substance, they act to inhibit the growth of bacteria, yeast, and mold even at concentrations that are harmless to the human body. Because of this property, it is widely used in foods and cosmetics to extend the shelf life.

However, parabens currently in use are known to cause skin diseases, central nerve palsy, and cancer due to most preservatives.

In particular, paraoxybenzoate (methylparaben) is a bacterium that cuts and sterilizes the DNA of bacteria, which occurs in the body of the person who consumed it, and can destroy human genes and cause cell death or mutation. There is a risk.

In addition, saccharin has a chemical formula of C ₇ H ₅ NO ₃ S, and the water-soluble saccharin does not disappear even if diluted by 10,000 times. It is used in place of sugar for diabetics for medical purposes. Previously, it was commonly used as a food additive with sugar, glucose, etc., but in 1992, it is used only for some foods such as pickles, soft drinks, processed meat products, special nutrition products, etc. due to the harmfulness of saccharin. Side effects of saccharin were gastrointestinal disorders, kidney failure, carcinogenicity, and when administered to rat oral cavity, severe injury to cerebral, cervical, and bladder cancer rabbits. Saccharin in particular has been strongly claimed to be a carcinogen, but according to a 2000 report by the National Institute of Environmental Health Sciences, there is no clear scientific evidence that there is a connection between saccharin and human cancer. Turned out not to be. However, we do not want to add synthetic chemical sweeteners that have been the subject of this controversy.

In addition, artificial pigments are pigments and dyes made to represent colors with chemical ingredients. According to recent FDA research data, artificial pigments are known to cause anxiety, irritability, distraction and distraction. The study results suggest that it may cause hyperactivity disorder and not only can cause fatal atopy and allergy but also cause brain nervous system abnormality. In addition, in Germany and the United Kingdom, artificial coloring is added to food and oral products by law.

Tar also refers to substances from wood and is used as an additive to flavor in candies and other foods. Heating the pine leaves the tar off the tree and leaves only charcoal. By-products of wood tar are turpentine and charcoal. By-products of deciduous distillation of deciduous trees are methanol and charcoal. Throat tar is dissolved in water to flavor candies and liquor or to spice up food. It is also used as an ingredient in cosmetics. Tar is an artificial sweetener. When tar and flaxseed oil are mixed, they become tar paint, which is translucent brown in color, which is used to tint wood and protect it from the weather. It is also used to make tobacco.

Fluorinated (fluorinated) hydrochloric acid and its salts are both toxic, but traces of fluoride ions in tap water are effective in preventing tooth decay. Fluorinated ions in water form the fluorapatite, [Ca3 (PO4) 2] 3.CaF2, which is harder than dentin. Dentin is composed of hydroxyapatite, [Ca3 (PO4) 2] 3.Ca (OH) 2, which contains a hydroxyl group (-OH), which can be corroded when it encounters an acid, but fluorapatite does not contain a hydroxyl group. Does not corrode by For this reason, some countries supply a small amount (less than 1 ppm) of fluorinated ions in tap water. However, too much fluorinated ions (2 to 3 ppm) have side effects such as spots, so concentration control is very important. Fluoride is widely used to prevent tooth decay and has been widely used in marketing, but recently, it is recognized as a harmful raw material as its side effects are revealed.

In Japanese Patent Laid-Open No. 55-120,509, herbal extracts such as bone extract, white leaf, fat milk, lotus root and leaf lobe are formulated to suppress the plaque bacterium effect. Japanese Patent Application Laid-Open Nos. 57-5641 and 57-85319 disclose berberine extracted from yellow and white, In Japanese Patent Laid-Open No. 87-51613, Flavonol is used In Japanese Unexamined Patent Publication No. 87-268613, moonflower seed oil is In addition, domestic patent registration number 0138244 contains herbal extracts to obtain periodontal disease, caries prevention and the like.

The purpose of the present invention was to develop the results of a thorough research to solve the above problems, with the exclusion of tar pigments, saccharin, parabens, artificial flavors harmful to teeth and fluoride less than 500ppm (less than half of the existing toothpaste) On the other hand, to provide an environmentally friendly function using a natural raw material, and also to remove the fine plaque by the double polishing method to provide a refreshing refreshing feeling and a whitening function improved after refreshing.

Highly functional toothpaste composition of the present invention for achieving the above object, 9.55-18% by weight of silicon dioxide; 0.38% by weight sodium monofluorophosphate; Aminocaproic acid 0.05-0.2% by weight; 0.12-0.2 weight% of allantoinchlorohydroxyaluminum; Glycerin 3-6% by weight; 4 to 7.72 weight percent of dental silica; PEG-1500 3-5 weight percent; 10-55% by weight of di-sorbitol solution; Carboxymethyl Cellulose Sodium 0.8-1.2 wt%; Xylitol 0.2-1% by weight; Phytoncide 0.1-1% by weight; Green tea 0.1-1% by weight; Bamboo salt from 0.1 to 4% by weight; Grapefruit seed extract 0.1-1% by weight; 0.1 to 0.3% by weight of sodium benjoate; Licorice extract 0.1-1% by weight; Gosam extract 0.1-1% by weight; Peppermint oil 0.1-1% by weight; L-menthol 0.1-2 wt%; Characterized in that 23 to 38% by weight purified water.

The addition of colloidal silicon dioxide is to give the plaque removal (anti-prag) function. Unlike precipitated carbonic acid, the crystal structure of silicon dioxide itself has a rounded shape, which minimizes tooth polishing and removes foreign substances adsorbed between and between teeth, thereby removing plaque and anti-whitening effect.

In other words, silicon dioxide, called SiO2, is a compound composed of silicon and oxygen, which are the most abundant elements in the earth's crust, and is a major component of 59% of the earth's crust and 95% or more of the rock. It has three main crystalline forms: mite and cristovalite. The role of silicon dioxide in the toothpaste of the present invention serves to gently remove impurities of the tooth into fine particles and to help the medicinal components to be well delivered to the teeth and gums. This can be said to have a whitening effect on whitening teeth. It also helps to make teeth stronger by recalculating calcium and phosphorus in the teeth.

Therefore, if the amount of silicon dioxide added is less than 9.55% by weight, foreign matter adsorbed on and between the teeth may be removed, which may weaken the function of plaque removal (antifrag). This may become strong and may damage teeth. For this reason, the content of 9.55-18 weight% is preferable.

The addition of sodium monofluorophosphate is to prevent tooth decay. Conventionally, it is generally added below 1000ppm (0.76%), but recently, it is habitual that users brush their teeth three times a day, so adding 0.38% by weight helps prevent dental health and fluoride toxins.

The aminocaproic acid (Aminocaproic Acid) is also called caprolactam in other words, the reason for the addition is a representative medicinal ingredient of toothpaste is added to have an excellent effect of gum disease, that is, anti-inflammatory, anti-bleeding.

Therefore, if the amount of aminocapronic acid is less than 0.05% by weight, the pharmacological function of anti-inflammatory, anti-bleeding, etc. may be weakened. On the contrary, when the amount of aminocapronic acid is more than 0.2% by weight, the effect of the above added ingredients may be weakened. A content of 0.2% by weight is preferred.

The addition of allantoin chlorohydroxy aluminum is intended to have an anti-inflammatory and skin roughness preventing function. Appearance is white powder, the biggest characteristic is to activate cell activity directly or indirectly. The most widely used field is used to treat gastrointestinal ulcers, and is widely applied to cosmetics due to its excellent pharmacological action and safety. When added to cosmetics, it prevents skin swelling. It is effective for acne and atopy due to its anti-inflammatory effect, and it is effective for making skin surface soft and smooth. In particular, it has excellent anti-inflammatory and sedative effects and promotes the growth of new tissues, so it is effectively used to treat damaged skin. A plant extract with sedative activity found in the comfrey root, is a raw material that is recognized as effective for gum disease in the KFDA as the aminocapron acid.

Therefore, the addition of allantoin chlorohydroxy aluminum less than 0.12% by weight may weaken the anti-inflammatory function of the toothpaste, on the contrary, if the content exceeds 0.2% by weight, the pharmacological action is increased, but the other efficacy of the added toothpaste may be weakened. have. For this reason, 0.12-0.2 weight% is preferable.

The addition of the xylitol is to exert a function of gum disease, periodontal disease and gum convergence. Xylitol is a natural sweetener proven by WHO and FDA that prevents mutans bacteria and promotes salivary secretion in the oral cavity.As the saliva contains calcium, which is essential for restoring teeth, tooth decay is suppressed as saliva secretion is smooth. By inducing salivary secretion to suppress caries, and also to prevent caries bacteria.

Therefore, if the added amount of xylitol is less than 0.2% by weight, the sweetening effect and the convergence function of the gum may be deteriorated. On the contrary, when the amount of the xylitol exceeds 1% by weight, the production cost may be increased and the efficacy of the added ingredients may be weakened. For this reason, 0.2-1 weight% is preferable.

The addition of the phytoncide is also intended to exert a function of gum disease, periodontal disease and gum convergence like xylitol. Phytoncide acts as a poison for trees to insulate themselves against various pests, fungi, germs, and bacteria, but it benefits humans. Phytoncide is a natural substance that is not a chemical synthetic substance, and is absorbed without human force, and has many functions such as antibacterial, deodorant, sedative, and stress relief to selectively sterilize harmful bacteria.

Therefore, when the amount of phytoncide added is less than 0.1% by weight, the gum disease, periodontal disease and gum convergence may be impaired. On the contrary, when the amount of phytoncide is exceeded by 1% by weight, manufacturing cost may be increased and the efficacy of the added ingredients may be weakened. There is. For this reason, 0.1-1 weight% is preferable.

The addition of the green tea is added to function in the mouth (구 中) clean, anti-prag and caries prevention. Flavonoids, rich in green tea, coat the tooth surface to protect the tooth surface from acids. In addition, the catechin component of green tea inhibits the development of tooth decay bacteria that cause tooth decay and inhibits the activity of substances that cause tartar formation. In addition to the caries prevention effect is effective in removing bad breath, preventing discoloration of teeth, bad breath.

Therefore, if the added amount of green tea is less than 0.1% by weight, there is a risk of weakening the cleansing function in the mouth, and if it exceeds 1% by weight, there is a fear of weakening the efficacy of the raw materials added together. For this reason, 0.1-1 weight% is preferable.

The bamboo salt is added to exert cell resiliency and anti-inflammatory function like aminocapron acid. Bamboo salt has lower sodium content compared to general sun salt, especially antibacterial, antiseptic, and osmotic pressure, sterilizes bacteria of gums and teeth, relieves inflammation in gums, and osmotic effect makes it easier and faster to deliver medicinal ingredients in toothpaste. Giving functions.

Therefore, if the added amount of bamboo salt is less than 0.1% by weight, there is a risk of sterilizing the bacteria of the gums and teeth and weakening the function of alleviating inflammation in the gums. There is concern. For this reason, 0.1-4 weight% is preferable.

The grapefruit seed extract is added to remove bad breath. Grapefruit seed extract contains a large amount of natural ascorbic acid, naringin and tocopherol, which is excellent in antibacterial and antioxidant activity for various foods. Non-metallic, non-corrosive, colorless, odorless natural organic mixture that does not cause environmental pollution. It strongly sterilizes, kills viruses, and fungi against the decaying and pathogenic microorganisms such as bacteria, fungi and viruses. It is known to be very safe for human body or animal because it is completely decomposed when absorbed into the body and there is no risk of toxicity due to accumulation in the body.It prevents rancidity of fat and suppresses the occurrence of rancidity and promotes palatability of food, It does not change the inherent taste, smell, or color of the animal feed, and stabilizes fat-soluble vitamins and pigments to maintain the effect of each substance.

Therefore, if the amount of the grapefruit seed extract is less than 0.1% by weight, there is a risk of weakening the bad breath removal function in the mouth, on the contrary, if it exceeds 1% by weight, there is a risk of increasing the manufacturing cost and weakening the efficacy of the raw materials added together. For this reason, 0.1-1 weight% is preferable.

The sodium benzoate (sodium benzoate) is added as a preservative to prevent rot of the product. Sodium benzoate has been approved and approved for use by the US FDA, the European Ministry of Health, the Japanese Ministry of Health, and the Korea Food and Drug Administration, and has been used as a safe preservative to prevent safety accidents caused by microorganisms in various foods without harm.

Therefore, if the added amount of sodium benzoate is less than 0.1% by weight, there is a risk of weakening the shelf life of the toothpaste, on the contrary, if the amount exceeds 0.3% by weight, there is a fear of weakening the efficacy of the raw materials added together. For this reason, 0.1 to 0.3 weight% is preferable.

The licorice extract is added to prevent gum disease and periodontal disease, such as phytoncide, the main component of licorice, glycyrrhizin is anti-inflammatory, antibacterial, antiviral, polyphenols anti-cancer function, and glabridine antioxidant and melanin It suppresses production.

Therefore, if the added amount of licorice extract is less than 0.1% by weight, there is a risk of weakening the gum disease and periodontal disease prevention function, such as phytoncide, On the contrary, if the content exceeds 1% by weight, the effect of the raw materials added together with the manufacturing cost will be weakened. There is concern. For this reason, 0.1-1 weight% is preferable.

The peppermint oil is added for the function of removing bad breath. It is a light yellow liquid obtained by cooling oil obtained by drying and distilling leaves and stems of peppermint. It has a unique fragrance and sour taste and is used as a refreshing agent in cosmetics, food and medicine.

Therefore, if the amount of peppermint oil is less than 0.1% by weight, there is a risk of weakening the bad breath removal function, on the contrary, if it exceeds 1% by weight, there is a fear of increasing the manufacturing cost and weakening the efficacy of the raw materials added together. For this reason, 0.1-1 weight% is preferable.

The L-menthol is added to remove the bad breath like peppermint oil. L-menthol, also known as peppermint brain, is a type of isoprenoid compound, a crystalline organic compound with a strong peppermint flavor, obtained from Japanese peppermint oil for centuries. The most common optical isomer in nature is l-menthol, which is left-rotating, present in peppermint oil. Small amounts of l-menthol are obtained from citronellal. The unique freshness not only gives your mouth a refreshing feel but also has the ability to remove bad breath.

Therefore, if the addition amount of L- menthol is less than 0.1% by weight, there is a risk of weakening the bad breath removal function, such as peppermint oil, on the contrary, if it exceeds 2% by weight may be rather uncomfortable with strong stimulation, and also weaken the efficacy of the raw materials added together There is a fear. For this reason, 0.1-2 weight% is preferable.

The ginseng extract is added to have an anti-inflammatory function, such as bamboo salt and aminocapronic acid, the ginseng has a component called matrine to activate the peristalsis of the intestine, especially used for eczema or skin purulent, warts, boils, scabies, etc. Used to get rid of pain and itching caused by it.

Therefore, if the added amount of high ginseng extract is less than 0.1% by weight, there is a risk of weakening anti-inflammatory functions such as bamboo salt and aminocaproic acid.On the contrary, if the amount exceeds 1% by weight, the cost of the raw materials added together with the production cost may be weakened. There is concern. For this reason, 0.1-1 weight% is preferable.

In the above, glycerin, polyethylene glycol (PEG-1500) and di-sorbitol solution were added as a wetting agent, silica as an abrasive and sodium carboxymethylcellulose as a binder.

According to the present invention, it excludes harmful tar pigments, saccharin, parabens, artificial flavors of the teeth, and contains various natural ingredients medicinal ingredients to have an environmentally friendly function, and also as medicinal ingredients caries and gingivitis, periodontitis (periodontal) It prevents periodontal disease and gum disease, improves oral cleansing, bad breath removal and plaque removal (anti-prag). Also, it reduces the fluorine content by more than half (1/2) and shows low irritation function. In addition, by removing the fine plaque by the double polishing method, there is an effect of improving the freshness and freshness after brushing, and the function of nature-friendly dental health to protect teeth white and healthy.

Hereinafter, a more preferred embodiment of the present invention will be described in detail.

The raw material of the toothpaste of the present invention is prepared in advance by weighing as shown in Table 1 below.

Raw Material and Content of Toothpaste Composition Raw material name Content (% by weight) Silicon dioxide 9.55-18 Sodium monofluorophosphate 0.38 Aminocaproic acid 0.05 to 0.2 Allantoinchlorohydroxyaluminum 0.12-0.2 glycerin 3 to 6 Dental Type Silica 4 ~ 7.72 PEG-1500 3 to 5 Di-sorbitol solution 10-55 Carboxymethyl Cellulose Sodium 0.8 ~ 1.2 Xylitol 0.2 ~ 1 Phytoncide 0.1 to 1 green tea 0.1 to 1 Bamboo salt 0.1 to 4 Grapefruit seed extract 0.1 to 1 Shodium Benjoate 0.1 to 0.3 Licorice extract 0.1 to 1 Gosam extract 0.1 to 1 peppermint oil 0.1 to 1 Elmenthol 0.1 ~ 2 Purified water 23-38 Sum 100

Extracts used in the present invention, that is, grapefruit seed extract, licorice extract and high ginseng extract extract the extraction solvent using alcoholic water and other organic solvents, the extraction method is a general percolation (silver percolation) method, silver needle method , Cold acupuncture or super criticalextrator method were used, and sugars such as glucose contained in the extract were removed as much as possible. Further, if necessary, the extract was adsorbed and filtered using an adsorbent such as activated carbon, diatomaceous earth, and acidic clay.

That is, 100 ml of 95% ethanol is added to 100 g of grapefruit seeds, and it is immersed at room temperature for 5 days. After 5 days, the filtrate was filtered and the filtrate was concentrated under reduced pressure. 5 g of 95% ethanol is diluted in 2 g of concentrated weight, and 3 g of distilled water is added to prepare a solution of 10 g of each herbal extract. The licorice extract and red ginseng extract are also prepared by the same method as described above.

<Examples>

Raw material name Content (% by weight) Silicon dioxide 15 Sodium monofluorophosphate 0.38 Aminocaproic acid 0.1 Allantoinchlorohydroxyaluminum 0.14 glycerin 4 Dental Type Silica 5 PEG-1500 4 Di-sorbitol solution 45 Carboxymethyl Cellulose Sodium 0.9 Xylitol 0.2 Phytoncide 0.1 green tea 0.1 Bamboo salt 0.5 Grapefruit seed extract 0.1 Shodium Benjoate 0.15 Licorice extract 0.2 Gosam extract 0.1 peppermint oil 0.1 Elmenthol 0.1 Purified water 23.83 Sum 100

In the weighed raw materials as shown in Table 2, only the remaining raw materials except extract, peppermint oil and elmenthol were added to the stirred tank with pre-prepared water with purified water and homogeneously mixed in a vacuum atmosphere of 10 ^-3 Torr for at least 1 hour. Then, the extracts weighed as shown in Table 2 were added to the secondary mixture homogeneously with the primary mixture under high vacuum as described above for 1 hour or more, and finally, peppermint oil and elmenthol weighed as shown in Table 2 were added thereto. To a homogeneous mixing under a high vacuum of 10 ^-3 Torr for at least 1 hour to obtain a toothpaste composition of the present invention.

<Experimental Example 1>

Heavy metal test results for the dentifrice composition obtained in the above Example were as shown in Table 3.

Test Items Specification value Remarks 1. Appearance

2.pH (stock solution)
3.Microorganisms
4.Heavy metal
Light brownish, slightly peculiar odor due to natural fragrance.
6.0 ± 1
100 colony / g or less
Lead: 20ppm or less
Arsenic: 2 ppm or less Confirm


No detection.
No detection.
No detection.

<Experimental Example 2>

The bactericidal power test results of the dentifrice composition obtained in Example were as shown in Table 4 below.

In the test method, the toothpaste and the existing toothpaste of Example were added to BHI (Brain Heart Infusion) by concentration of 0.01% to 0.9%, and the test of Table 4 below, which is a factor of oral diseases such as caries, gingivitis, periodontitis and gum disease. Strains were inoculated and incubated at 40 ° C. for 24 hours. The lowest concentration at which the test bacteria did not grow was MIC (µg / ml medium).

Test bacteria Invention Counterpart Streptococcus Mutans ATCC 27607 0.05 0.15 Rothia Dentocariosa ATCC 19426 0.07 0.19 Actinomyces Viscocus KTCT 9146 0.05 0.18 Escherichia Coli ATCC 8739 0.06 0.15

<Experimental Example 3>

The whiteness of the toothpaste composition obtained in the above example was measured. The results are shown in Table 5 below.

In the test method, the white cloth stained with black tea was first measured by using a colorimeter (model: SZ, Nippon Denshoku). Then, 50 ml of distilled water was added to each beaker of 100 ml, and the stained white cloth was placed in a beaker with distilled water. Then, 6 g of the toothpaste and the control toothpaste of the present invention were added and stirred for 60 minutes. After stirring, the white cloth was taken out and dried, and the degree of stain removal was measured using a color difference meter and evaluated as a percentage.

division Invention Counterpart Whiteness Assessment for White Cloth 98 95

As shown in Table 5, the whitening of the teeth of the people was not directly measured, but the whiteness improvement effect on the stain of the white cloth can be indirectly confirmed that there is a whitening effect on the teeth.

<Experimental Example 4>

50 adult men and women complaining or diagnosed symptoms such as periodontitis, toothache, bad breath, and tooth decay were continued to use the toothpaste obtained in the above example three times a day for 30 days, and the effect was evaluated by a questionnaire. The results are shown in Table 6 below.

Effect Determination Disease No effect Effective Considerable effect Cure effect system toothache 2 6 3 One 12 Periodontitis One 7 5 4 17 Bad breath 3 4 One 4 12 Caries prevention One 4 3 One 9 system 7 (14%) 21 (42%) 12 (24%) 10 (20%) 50 (100%)

As shown in the results of the experiment, toothpaste (89%), periodontitis (94%), bad breath (83%), and tooth decay prevention (75%) were alleviated when the toothpaste of the present invention was used steadily. Able to know.

<Experimental Example 5>

50 adult men and women were attached to the inner soft skin of the upper arm and the toothpaste prepared according to the above-described prescription of the present invention after 12 hours, the skin irritation, erythema, itching, allergies and the like. The results were shown in Table 7 below.

 Skin irritation % Of respondents  No change in skin  45 (90%) Slight itching after removal   2 (4%) The attachment area is slightly red but disappears after 1-2 hours   3 (6%)  Significant irritation   0 (0%)

Test results show that the toothpaste of the present invention does not irritate the skin.

<Experimental Example 6>

50 adult men and women were brushed for 3 minutes using the toothpaste and the existing toothpaste according to the present invention and the freshness and freshness after the mouth was gargled with water were investigated. The results were shown in Table 8 below.

 Skin irritation % Of respondents I do not know  2 (4%) No difference   3 (6%) Refreshing and refreshing.   45 (90%)

As a result of the test, the toothpaste of the present invention was found to give a refreshing feeling compared to the existing toothpaste, and in particular, such a test result is also indirectly confirmed to be a functional toothpaste having a natural affinity.

Claims (1)

Toothpaste composition mixed with the following components.
9.55-18% by weight of silicon dioxide;
0.38% by weight sodium monofluorophosphate;
Aminocaproic acid 0.05-0.2% by weight;
0.12-0.2 weight% of allantoinchlorohydroxyaluminum;
Glycerin 3-6% by weight;
4 to 7.72 weight percent of dental silica;
PEG-1500 3-5 weight percent;
10-55% by weight of di-sorbitol solution;
Carboxymethyl Cellulose Sodium 0.8-1.2 wt%;
Xylitol 0.2-1% by weight;
Phytoncide 0.1-1% by weight;
Green tea 0.1-1% by weight;
Bamboo salt from 0.1 to 4% by weight;
Grapefruit seed extract 0.1-1% by weight;
0.1 to 0.3% by weight of sodium benjoate;
Licorice extract 0.1-1% by weight;
Gosam extract 0.1-1% by weight;
Peppermint oil 0.1-1% by weight;
L-menthol 0.1-2 wt%; And
23-38 wt% of purified water