KR102171798B1 - Composition for treating oral disease and inhibiting halitosis containing natural extracts and preparation method therefor - Google Patents

Abstract

The composition for reducing bad breath and preventing periodontal disease containing the natural extract of the present invention does not contain hydrogen peroxide or titanium dioxide, and uses a natural extract to reduce bad breath and prevent periodontal disease, and at the same time, it has excellent human body stability. It provides a composition for reducing and preventing periodontal disease, and also, it is possible to prevent damage to periodontal tissue and symptoms of tooth aching.

Description

Composition for reducing bad breath and preventing periodontal disease, including natural extracts, and a manufacturing method thereof {COMPOSITION FOR TREATING ORAL DISEASE AND INHIBITING HALITOSIS CONTAINING NATURAL EXTRACTS AND PREPARATION METHOD THEREFOR}

The present invention relates to a composition for reducing bad breath and preventing periodontal disease, including a natural extract, and a method for preparing the same. More specifically, it does not contain chemicals such as hydrogen peroxide, and relates to a composition for reducing bad breath and preventing periodontal disease using a natural extract, and a method of manufacturing the same.

As the concept of dental health has changed to the concept of social life, interest in oral health is increasing, and not only for the prevention and treatment of oral diseases and rehabilitation for loss of function, but also for bad breath, which is an important obstacle to interpersonal relationships in social life. Interest is also increasing.

The causes of such bad breath are largely classified into oral causes, extraoral causes, and psycho-human causes, and among them, the cause of the oral cavity accounts for 80-90% of the causes of bad breath, which reduces the amount of saliva, increases the consistency of saliva, and decreases the buffering capacity of hydrogen ion concentration. , Increase in the amount and activity of oral microbes, tongue and tongue attached to the back of the tongue, and oral diseases such as untreated dental caries and periodontal disease, and among them, tongue tongue occupies the largest proportion.

As a cause of oral cavity, it is known that volatile sulfur compounds (VSCs), which are caused by bacterial decay by Gram-negative anaerobic bacteria, account for most of oral odor. Bad breath caused by metabolism of bacteria, which accounts for most of them, is caused by anaerobic bacteria decomposing amino acids including sulfur, which are volatile sulfur compounds such as hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. It produces n-tetradecanol, phenol, diphenylamine, and pyridine. Out-of-mouth causes of bad breath may include respiratory diseases, neurological gastrointestinal diseases, various other diseases, and the use of certain drugs.In addition, bad breath physiologically occurs when fasting, waking up, menstruation, smoking, and drinking. Can occur.

On the other hand, among oral diseases, dental caries (caries) and periodontal disease are known to cause various clinical symptoms such as pain, masticatory dysfunction, destruction of periodontal tissue, and bad breath, and are known to be the main factors that cause tooth loss. The causative factor of caries is on the rise. According to the WHO recently, more than 60% of adults around the world reported having two major oral diseases, dental caries and periodontal disease.

It is a method of inhibiting the proliferation of oral pathogens that inhabit the tooth surface bacterial membrane and cause dental caries, periodontal disease and bad breath. Various types of antibacterial agents including antibiotics having sterilization and bacteriostatic action against these bacteria are used to treat tooth decay, periodontal disease, pulp and It has been developed as a treatment and inhibition of apical infection.

However, antibiotics are difficult to use for a long time because they can cause systemic side effects on our body and the appearance of resistant bacteria in the oral cavity and bacterial alternation, so that they can be used only as therapeutic agents. In addition, in the case of fluoride, an antibacterial agent, the effect of preventing tooth decay is clear, but no effect has been reported on periodontal, pulp, or apical diseases. Other antibacterial agents used in toothpaste, toothpaste, and other mouthwashes include saengguinarine, listerin, pyroxide, and chlorhexidine. Sangquinarine has an unclear effect on bacteria in the oral cavity, and periodontal disease The treatment effect is not only more unclear, but also has a high price.Listerine is mainly alcohol-based and has a slight bacteriostatic effect that has a temporary effect in the oral cavity.However, when used for a long period of time, it may also cause harm to the tissues. In addition, pyroxide, which is recently added for whitening effect, has a toxic effect on bacteria, but at the same time, it has a toxic effect on human tissues, so there is a problem in safety, and sometimes bacteria resistant to peroxide appear. do.

In addition, Chlorhexidine is known to be the best among the formulations known to date as a prevention and treatment for periodontal disease along with inhibition of plaque formation, but it has side effects of irritation, tissue coloration and degeneration, especially stimulating taste and severe odor. In addition to the problems indicated, there are other drawbacks that cannot be used for a long period of time for treatment or especially for the purpose of prevention, such as the possibility of causing mycosis and limiting use in the case of pregnant women due to carcinogenicity (Contemporary periodontics [ed. RJ Genco et al.], p161-169, p368-369, p433, CV Mosby Company, St. Louis, 1990).

Accordingly, the present inventors have conducted studies on various plants in order to derive natural materials having antibacterial effects against oral pathogens and effective bad breath suppression effects without concern for the above-described side effects.

KR 10-2000-0079562 A1

An object of the present invention relates to a composition for reducing bad breath and preventing periodontal disease having excellent antibacterial effect and halitosis inhibitory activity against oral microorganisms (pathogens).

Another object of the present invention is to provide a composition for reducing bad breath and preventing periodontal disease, which is excellent in human stability while exhibiting excellent bad breath reduction and periodontal disease prevention effects by using natural extracts.

Another object of the present invention is to provide a composition for reducing bad breath and preventing periodontal disease, including a natural extract capable of preventing damage to periodontal tissue and symptoms of aching teeth caused by the use of a composition for preventing periodontal disease.

In order to achieve the above object, the composition for reducing bad breath and preventing periodontal disease according to an embodiment of the present invention is a natural extract selected from the group consisting of dermis extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof. It may include.

The composition for reducing bad breath and preventing periodontal disease may further include a natural powder selected from the group consisting of sangbaek skin powder, mountain birch leaf powder, and mixtures thereof.

The composition for reducing bad breath and preventing periodontal disease may further include purified water.

The composition for reducing bad breath and preventing periodontal disease may further include one selected from the group consisting of grapefruit seed extract, propolis, and mixtures thereof.

The composition for reducing bad breath and preventing periodontal disease may further include xylitol, peppermint essential oil, vegetable glycerin, an abrasive and a thickener.

It relates to a toothpaste for reducing bad breath and preventing periodontal disease, including the composition for reducing bad breath and preventing periodontal disease according to another embodiment of the present invention.

It relates to a mouthwash for reducing bad breath and preventing periodontal disease, including the composition for reducing bad breath and preventing periodontal disease according to another embodiment of the present invention.

A method of preparing a composition for reducing bad breath and preventing periodontal disease according to another embodiment of the present invention comprises: 1) mixing and dissolving vegetable glycerin, xylitol and a thickener to prepare a first mixture; 2) a natural extract selected from the group consisting of a dermis extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof in the first mixture of step 1); And adding a surfactant and mixing to prepare a second mixture. 3) adding an abrasive to the second mixture of step 2) and mixing to prepare a third mixture; And 4) adding peppermint essential oil to the third mixture of step 3).

The second mixture of step 2) may further include a natural powder selected from the group consisting of chamomile powder, mountain birch leaf powder, and mixtures thereof.

The second mixture of step 2) may further include purified water.

The third mixture of step 3) may further include those selected from the group consisting of grapefruit seed extract, propolis, and mixtures thereof.

Hereinafter, the present invention will be described in more detail.

The composition for reducing bad breath and preventing periodontal disease comprising a natural extract according to an embodiment of the present invention comprises a natural extract selected from the group consisting of a dermis extract, a strawberry extract, a cortex extract, a lemon extract, a pine needle extract, and a mixture thereof do. Preferably, it may include a mixture of dermis extract, strawberry extract, mortar extract, lemon extract and pine needle extract.

When the dermal extract is used as a composition for reducing bad breath and preventing periodontal disease, it is excellent in reducing bad breath and preventing periodontal disease by vitamins and amino acids contained in the dermal extract and strawberry extract. More specifically, the vitamins and amino acids contained in the dermal extract and strawberry powder have an excellent effect on reducing bad breath, and at the same time, the pH of saliva (saliva) is maintained to be alkaline to prevent plaque deposition, thereby preventing dental caries and periodontal disease. I can.

The dermis (Citrus Unshiu Pee) is a medicinal material defined as the ripe fruit peel of Citrus unshiu Markovich or Citrus reticulata Blanco (Wunhyang family Rutaceae). When quantified, it contains 4.0% or more of hesperidin (C ₂₈ H ₃₄ O ₁₅ : 610.56) with respect to the converted dry matter. It is a plate-like shell with an irregular shape and is about 2mm thick. The outer surface is yellow-red or dark brown, and there are many small concave marks by loss. The inside is white or light gray brown, and the quality is light and fragile. In oriental medicine, the efficacy of Igi, Josup, Jojung, Jisa, Jiae, Jihae, Pleasure, and Hwadam are effective. have. In the dermis component studies so far, 28 types of flavonoid-based compounds have been reported, and in addition, monoterpenoid-based compounds have been separately reported. As pharmacological action, lipase activity, anti-ulcer treatment effect, blood pressure lowering effect, antiviral action, anti-inflammatory action, antiallergic action, platelet aggregation action, and anticancer action have been reported.

The dermis extract has a high content of vitamin A and vitamin C, and contains sugars and organic acids. More specifically, proteins, sugars, lipids, beta-carotene, vitamin A, vitamin C, dietary fiber, amino acids, and the like are included.

Strawberries (Fragaria Chiloensis (Strawberry)) belong to the perennial plant of the Rosaceae Rosaceae, a dicotyledonous plant, and are mainly used for food. Unlike other fruits that develop ovaries and become fruits, strawberries are characterized by the development of flower sills and seeds are like sesame seeds on the surface of the fruit. It is usually red, but sometimes, there are varieties that have a white color. Strawberries contain flavonoids and show excellent effects on skin beauty.

Sangbaekpi (Mori Radicis Cortex) is a medicinal material made from the root bark of a mulberry or a genus plant. Sangbaekpi cures seawater and asthma caused by waste heat and has a diuretic effect. It is used for acute pyelitis and weak edema, has a blood pressure lowering effect, and is also used for nosebleeds and keratin. It is also used for epidemic hepatitis. Pharmacological action has been reported as antitussive, diuretic, lowering blood pressure, sedation, analgesic, antipyretic, antispasmodic, and antibacterial action. Morus alba Linne contains scopoletin, umbelliferone, triterpenoids, amyrin, and betulinic acid, which are coumarin derivatives such as mulberline, mulverrocraven, cyclomulverine, etc. It is known as an excellent medicine with antitussive, antibacterial, anti-inflammatory, and antioxidant effects. Morus alba L. is the cork layer removed from the root skin of the mulberry tree (Morus alba L.) and the root coat of the genus of the same genus. Wash the root in winter, wash it clean, peel off the cork layer when fresh, split it vertically and tap it with a wooden hammer to separate the neck and skin Only drunk. The taste is sweet and the temper is cold. Sangbaekpi has been used in oriental medicine for diabetes treatment, diuretics, antiemetics, and laxatives (Giaccia A. et al. Nat Rev Drug Disc 2; 803-811, 2003). Ingredients are several compounds such as prenylated flavonoid, benzofuran, and phenol-based compounds. These compounds generate cytotoxicity, COX-1, COX-2, and nitric oxide (NO). Various biological activities such as inhibitory effects have been reported. The main physiologically active ingredients include Umblliferone, mulberrochromene, cyclomulberrin, and cyclomulberrochromene, and work with acetyl choline. It contains similar anti-inflammatory properties.

Lemon (lemon) is a 　fruit belonging to the genus 　. Lemon juice has a lot of citric acid, has a lot of acidity, has little sweetness and a strong sour taste, and has a pH of 2 to 3. Lemon contains vitamin C, complex B vitamins, calcium, iron, magnesium, potassium, and fiber.

Pine needles are the leaves of pine trees. Pine (Pinus densiflora Seibold et Zuccarini) is an evergreen coniferous arboreous tree that is wild in the mountains of Korea. It is mainly composed of red pine, which grows mainly in inland areas, and is mainly composed of white pine, Rigida pine, Gomsol, and white pine have. Pine needles, which are the leaves of pine trees, have been used for medicinal or health food in oriental medicine or folk remedies. According to Donguibogam, pine needles are known to be effective in treating gastrointestinal diseases, stroke, high blood pressure, neuralgia, and asthma. These pharmacological actions of pine needles are functional substances such as essential oils, protein, vitamin A, vitamin C, vitamin K, vitamin P (routine), phosphorus, iron, enzymes, tannins, chlorophyll, bitter taste substances, flavonoids, etc. Made by In particular, vitamin P (routine) has an excellent effect in promoting blood circulation and preventing high blood pressure and aging. In addition, the volatile essential oil of pine needles plays a role in relieving fatigue during forest bathing. Pine needle extract is added to the herbal mixture extract corresponding to moxibustion to enhance immune function, anti-inflammatory and various beneficial physiological activities.

The dermis extract; Strawberry extract; Sangbaekpi extract; Lemon extract; And the pine needle extract means an extract extracted by hot water extraction or ethanol solvent extraction, and more specifically, a hot water extract. In the hot water extraction, distilled water is used as an extraction solvent, and extraction is performed at a temperature of 30 to 80°C, and more specifically, extraction may be performed at a temperature of 40 to 70°C.

The composition for reducing bad breath and preventing periodontal disease may further include a natural powder selected from the group consisting of sangbaek skin powder, mountain birch leaf powder, and mixtures thereof. Preferably, it may additionally include a chamomile powder and a birch leaf powder, but is not limited to the above example.

As for the above-mentioned Sangbaekpi powder, it is possible to use a Sangbaekpi powder readily available on the market. The above-mentioned Sangbaekpi powder includes Sangbaekpi powder, separately from the Sangbaekpi extract, so that the Sangbaekpi powder directly contacts the teeth when used, thereby further maximizing the effect of reducing bad breath and preventing periodontal disease. In other words, by including a natural extract in the composition for reducing bad breath and preventing periodontal disease, active ingredients contained in the natural extract are mixed, so that the upper white skin powder can directly contact the surface of the teeth, thereby preventing the tooth whitening effect due to the upper white skin powder. Can be maximized.

The composition for reducing bad breath and preventing periodontal disease includes a natural extract selected from the group consisting of a dermal extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof, and the natural extract is more specifically a dermal extract , Strawberry extract, epidermis extract, lemon extract, and pine needle extract. Preferably, based on 100 parts by weight of the dermis extract, 100 to 150 parts by weight of strawberry extract; 100 to 150 parts by weight of the extract of Serrata; 100 to 150 parts by weight of lemon extract; Including 100 to 150 parts by weight of pine needle extract and 5 to 20 parts by weight of cornea powder, and more specifically, 100 parts by weight of strawberry extract based on 100 parts by weight of dermis extract; 100 parts by weight of Sangbaekpi extract; 100 parts by weight of lemon extract; 100 parts by weight of pine needle extract; It may include 5 to 20 parts by weight of chamomile powder and 5 to 20 parts by weight of birch leaf powder, but is not limited to the above example.

In the case of including the above 5 parts by weight of the sesame seed powder and less than 5 parts by weight of the birch leaf powder, there is a problem that the synergistic effect of reducing bad breath and preventing periodontal disease due to the inclusion of the sesame seed powder is insufficient, and when it exceeds 20 parts by weight, There is a problem that micro-damage to the gums may occur due to the inclusion of a large amount of upper white skin powder.

The natural extract selected from the group consisting of the dermis extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof contains a large amount of vitamins and amino acids, and thus has excellent effect of reducing bad breath and alkalizing the pH of saliva (saliva). And, it can prevent periodontal tissue damage and tooth aching symptoms.

In addition, the additionally included mortar powder and mountain birch leaf powder also contain a large amount of vitamins and amino acids, so that they directly contact the tooth surface, reducing bad breath and preventing periodontal disease, and preventing damage to periodontal tissue, It can exhibit excellent anti-inflammatory effects.

The composition for reducing bad breath and preventing periodontal disease may further include purified water.

The composition for reducing bad breath and preventing periodontal disease may include a natural extract selected from the group consisting of a dermal extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof; Sesame powder; Contains mountain birch leaf powder and purified water. More specifically, dermal extract; Strawberry extract; Sangbaekpi extract; Lemon extract; Pine needle extract; Sesame powder; It may contain mountain birch leaf powder and purified water. Dermal extract in the composition for reducing bad breath and preventing periodontal disease; Strawberry extract; Sangbaekpi extract; Lemon extract; Even if it contains only pine needle extract, mosquito powder, and mountain birch leaf powder, it has excellent effect of reducing bad breath and preventing periodontal disease, but it is more effective in reducing bad breath and preventing periodontal disease when further purified water is mixed.

Preferably, the composition for reducing bad breath and preventing periodontal disease comprises purified water, and based on 100 parts by weight of the purified water, 30 to 60 parts by weight of a dermal extract; 30 to 60 parts by weight of strawberry extract; 30 to 60 parts by weight of the extract of Serrata; 30 to 60 parts by weight of lemon extract; 30 to 60 parts by weight of pine needle extract; 1 to 10 parts by weight of sesame powder; And 1 to 10 parts by weight of mountain birch leaf powder, and more specifically, 50 parts by weight of a dermal extract based on 100 parts by weight of purified water; 50 parts by weight of strawberry extract; 50 parts by weight of serrata extract; 50 parts by weight of lemon extract; 50 parts by weight of pine needle extract; 1 to 10 parts by weight of sesame powder; And 1 to 10 parts by weight of mountain birch leaf powder, but are not limited to the above example. The dermis extract; Strawberry extract; Sangbaekpi extract; Lemon extract; And when containing less than 30 parts by weight of pine needle extract, there is a problem that the effect of reducing bad breath is insufficient, and when each exceeding 60 parts by weight, abrasives, preservatives and thickeners that may be additionally included in the composition for reducing bad breath and preventing periodontal disease There is a risk of weakening the function of the back.

The composition for reducing bad breath and preventing periodontal disease may further include xylitol, peppermint essential oil, vegetable glycerin, an abrasive, a preservative, and a thickener.

The xylitol is a sugar alcohol-based natural sweetener used in chewing gum, confectionery, pharmaceuticals, oral hygiene, and the like. Xylitol is effective in preventing tooth decay because it has a pentose structure. The phenomenon that lactic acid, which is released by eating glucose or fructose in food by the caries mutans or sorbinus bacteria, corrodes the surface of the teeth, but the caries bacteria easily decomposes hexose, but does not easily decompose xylitol, which is the pentasaccharide. can not do it. As a result, the acid, which is the cause of tooth decay, does not occur, and the caries bacteria that do not consume nutrients eventually fall off the tooth surface. In addition, xylitol is also used as an additive to prevent tooth decay because it is suitable for preventing tooth decay, such as promoting saliva secretion, as it has a refreshing effect to cool the mouth.

The vegetable glycerin is also called 　glycerol and has a sweet taste in the form of a transparent syrup. Glycerin prevents moisture evaporation and helps supply moisture. In addition, glycerin is harmless to the human body, has excellent moisturizing effect, and has strong hygroscopic power. Vegetable glycerin is a natural product made from palm oil and palm oil as raw materials. It is a component that is easily soluble in water. It has the effect of suppressing dermatitis, especially when used in the oral cavity, and can prevent dry mouth.

In the peppermint essential oil, peppermint (Mentha piperita) contains menthol and menthone as constituents, is effective in treating itching or inflammation, and is known to be effective in antiseptic, anticonvulsant and expectorant. .

In particular, peppermint's anticonvulsant action is based on its action on the nervous system, and the fresh and spicy menthol flavor awakens the nerves and brain to improve concentration. It has a local anesthetic effect on muscle pain, back pain, bruises, joint pain, and toothache. In addition, it is one of the most effective oils for the digestive system and is effective for indigestion, motion sickness, stomach pain, diarrhea and flatulence. By constricting blood vessels, it accelerates the flow of blood vessels to the spleen and promotes blood cell regeneration. In addition, it constricts and relaxes lymph and fascia, strengthening the smooth toxin release function, and helps relieve headaches and migraines.

The thickener is for maintaining a constant viscosity, and may include a thickener of natural ingredients. The thickener is selected from the group consisting of xanthan gum, natural cellulose, high cell, methylcellulose, carbomer, carbopol pregel, and gelatin, and more specifically xanthan gum, but is not limited to the above examples.

The preservative includes grapefruit seed extract, which is a natural material, and the grapefruit seed extract and propolis are natural sterilization, disinfection, and preservatives. Medically, it can be used as an oral medicine for bacterial or bacterial infections, such as wounds, otitis media, and sore throat. It is also used as an external medicine. It is extracted from grapefruit seeds and contains a large amount of natural ascorbic acid, naringin and tocopheron, so when added, it can suppress the generation of toxicity and deterioration products with excellent antibacterial and antioxidant effects.

The abrasive may be selected from the group consisting of baking soda, calcium carbonate, and mixtures thereof, and precipitated calcium carbonate may be used as an example of the calcium carbonate. Such baking soda; Calcium carbonate; Alternatively, precipitated calcium carbonate can remove plaque from the tooth surface.

The composition for reducing bad breath and preventing periodontal disease of the present invention may further include a pigment, and the pigment may be a general one used in the art, preferably titanium oxide, 　 silicon dioxide and titanated mica It may be selected from the group consisting of.

The composition for reducing bad breath and preventing periodontal disease of the present invention may further include a surfactant, and the surfactant is selected from the group consisting of apple surfactant, cocobetamine, sugar surfactant, olive surfactant, and mixtures thereof. , It is preferably apple surfactant and cocobetamine, but is not limited to the above examples.

In addition, the composition for reducing bad breath and preventing periodontal disease of the present invention may further include other additives, and the other additives may be selected from the group consisting of vitamin E, xylitol, vitamin C, propolis, and mixtures thereof. The other additives may further increase the effect of preventing periodontal tissue damage and tooth aching symptoms.

In addition, the propolis is a natural antibacterial substance as a mixture of resinous substances collected by bees from plants such as tree shoots and sap. It has antibacterial, bactericidal and immune activation, immune function strengthening, cell activation and cell regeneration, anti-allergic, gene damage defense, blood vessel strengthening, antioxidant, and anticancer drug side effects. Also, propolis works to control symptoms.

As used herein, the term'extract' has the meaning commonly used as a crude extract in the art as described above, but broadly includes a fraction obtained by further fractionating the extract. That is, the plant extract includes not only those obtained using the above-described extraction solvent, but also those obtained by additionally applying a purification process thereto. For example, fractions obtained by passing the extract through an outer filtration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity), etc. Fractions obtained through various purification methods are also included in the plant extract of the present invention.

The extract used in the present invention may be prepared in a powder state by an additional process such as distillation under reduced pressure and freeze drying or spray drying.

A method of preparing a composition for reducing bad breath and preventing periodontal disease according to another embodiment of the present invention includes: 1) mixing and dissolving vegetable glycerin, xylitol and a thickener to prepare a first mixture; 2) a natural extract selected from the group consisting of a dermis extract, strawberry extract, mortar extract, lemon extract, pine needle extract, and mixtures thereof in the first mixture of step 1); And adding a surfactant and mixing to prepare a second mixture. 3) adding an abrasive to the second mixture of step 2) and mixing to prepare a third mixture; And 4) adding peppermint essential oil to the third mixture of step 3).

More specifically, the thickener is for maintaining a constant viscosity, and may include a thickener of natural ingredients. The thickener is selected from the group consisting of xanthan gum, natural cellulose, high cell, methylcellulose, carbomer, carbopol pregel, and gelatin, and more specifically xanthan gum, but is not limited to the above examples.

Step 1) is a step of mixing and dissolving vegetable glycerin, xylitol, and a thickener. More specifically, after heating vegetable glycerin, xylitol is added and dissolved. Thereafter, a thickener is added and dissolved to prepare a first mixture.

Thereafter, after adding a natural extract and a surfactant selected from the group consisting of a dermis extract, a strawberry extract, a corn extract, a lemon extract, a pine needle extract, and a mixture thereof to the first mixture of step 1), a second mixture was prepared. do.

The first mixture of step 1) may further include a pigment, and the pigment may be a general one used in the art, preferably from the group consisting of titanium oxide, silicon dioxide and titanated mica. Can be chosen.

In addition, the first mixture of step 1) may further include other additives, and the other additives may be selected from the group consisting of vitamin E, xylitol, vitamin C, and mixtures thereof.

Thereafter, the abrasive and the grapefruit seed extract are added to the second mixture, followed by mixing to prepare a third mixture. The grapefruit seed extract is a natural preservative.

The grapefruit seed extract is a natural sterilization, disinfection, and preservative, and medically, it can be used as an internal medicine for bacterial or bacterial infection, and is also used as an external medicine for wounds, otitis media, and sore throat. It is extracted from grapefruit seeds and contains a large amount of natural ascorbic acid, naringin and tocopheron, so when added, it can suppress the generation of toxicity and deterioration products with excellent antibacterial and antioxidant effects.

The abrasive may be selected from the group consisting of baking soda, calcium carbonate, and mixtures thereof, and precipitated calcium carbonate may be used as an example of the calcium carbonate. Such baking soda; Calcium carbonate; Alternatively, precipitated calcium carbonate can remove plaque from the tooth surface.

Finally, peppermint essential oil is added to the third mixture, and then mixed to prepare a composition for reducing bad breath and preventing periodontal disease according to an embodiment of the present invention.

The second mixture of the step 2) may further include a chamomile powder and a birch leaf powder. When the second mixture is prepared, the above-mentioned mulberry powder and mountain birch leaf powder may be additionally included. Since the Sangbaek skin powder contains vitamins and aminenoic acid as active ingredients, it is included in the composition for reducing bad breath and preventing periodontal disease, and when used, it can contact the tooth surface to increase the effect of reducing bad breath and preventing periodontal disease.

The second mixture of step 2) may further include purified water. When the purified water was included in the composition for reducing bad breath and preventing periodontal disease, it was confirmed that the effect of reducing bad breath was increased compared to the case without including it.

Thus, the second mixture contains purified water, and based on 100 parts by weight of the purified water, 30 to 60 parts by weight of a dermal extract; 30 to 60 parts by weight of strawberry extract; 30 to 60 parts by weight of the extract of Serrata; 30 to 60 parts by weight of lemon extract; 30 to 60 parts by weight of pine needle extract; It may include 1 to 10 parts by weight of sangbaek powder and 1 to 10 parts by weight of birch leaf powder. The dermis extract; Strawberry extract; Sangbaekpi extract; Lemon extract; And when the pine needle extract is included in an amount less than 30 parts by weight, there is a problem that the effect of reducing bad breath and preventing periodontal disease is insufficient, and when each exceeding 60 parts by weight, an abrasive that may be additionally included in the composition for reducing bad breath and preventing periodontal disease, There is a risk of weakening the functions of preservatives and thickeners.

The composition for reducing bad breath and preventing periodontal disease of the present invention uses a natural extract, which is a natural material, and at the same time exhibits an excellent bad breath reduction effect and is excellent in human stability.

In addition, according to the use of the composition for reducing bad breath and preventing periodontal disease of the present invention, it is possible to prevent periodontal disease by preventing plaque deposition by maintaining the pH of saliva (saliva) to be alkaline, and to damage periodontal tissue and sore teeth. Symptoms can be prevented.

1 is a flow chart illustrating a method of preparing a composition for reducing bad breath and preventing periodontal disease according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein.

[Production Example 1: Preparation of plant extract]

1. Preparation of Dermal Extract (E1)

After preparing an extract by hot water extraction at 100° C. for 4 hours using 20 times the volume of distilled water on the dried dermis, the extract was filtered through filter paper and reduced pressure to prepare a dermal extract (E1).

2. Strawberry extract (E2)

After preparing an extract by hot water extraction at 100° C. for 4 hours using 20 times the volume of distilled water on the dried strawberry, the extract was filtered through a filter paper and reduced pressure to prepare a strawberry extract (E2).

3. Sangbaek peel extract (E3)

After the extract was prepared by hot water extraction at 100° C. for 4 hours using 20 times the volume of distilled water on the dried serrata, the extract was filtered through a filter paper and reduced pressure to prepare sangbaek-pi extract (E3).

4. Lemon extract (E4)

After extracting the dried lemon with hot water at 100° C. for 4 hours using 20 times the volume of distilled water, the extract was filtered through a filter paper and reduced pressure to prepare a lemon extract (E4).

5. Pine needle extract (E5)

After extracting the dried pine needles with hot water at 100° C. for 4 hours using 20 times the volume of distilled water, the extract was filtered through a filter paper and reduced pressure to prepare a pine needle extract (E5).

6. Mortar powder (E6)

The dried serrata was pulverized using a pulverizer to prepare sangbaek powder (E6).

7. Mountain birch leaf powder (E7)

The dried birch leaves were pulverized using a pulverizer to prepare birch leaf powder (E7).

[Production Example 2: Preparation of composition for reducing bad breath and preventing periodontal disease]

A composition for reducing bad breath and preventing periodontal disease was prepared with the composition shown in Table 1 and Table 2 below. A specific manufacturing method was prepared by the method of preparing a composition for reducing bad breath and preventing periodontal disease of the present invention.

Experiment number E1 E2 E3 E4 E5 E6 E7 TC 1 100 100 100 100 100 5 5 TC 2 100 100 100 100 100 10 10 TC 3 100 100 100 100 100 20 20 TC 4 100 150 100 100 100 5 5 TC 5 100 150 100 100 100 10 10 TC 6 100 150 100 100 100 20 20 TC 7 100 100 150 100 100 5 5 TC 8 100 100 150 100 100 10 10 TC 9 100 100 150 100 100 20 20 TC 10 100 100 100 150 100 5 5 TC 11 100 100 100 150 100 10 10 TC 12 100 100 100 150 100 20 20 TC 13 100 100 100 100 150 5 5 TC 14 100 100 100 100 150 10 10 TC 15 100 100 100 100 150 20 20 TI 1 - - - - - - -

(Unit parts by weight, as other constituents, glycerin 105 parts by weight, xanthan gum 7 parts by weight, grapefruit seed extract 11 parts by weight, vitamin E 11 parts by weight, xylitol 50 parts by weight, vitamin C 42 parts by weight, calcium carbonate 320 parts by weight, Baking soda 53 parts by weight, silicon dioxide 105 parts by weight, propolis 10.5 parts by weight, apple surfactant 53 parts by weight, cocobetamine 32 parts by weight and peppermint essential oil 0.1 parts by weight, Comparative Example 1 other constituents other than natural extracts Only)

Experiment number Purified water E1 E2 E3 E4 E5 E6 E7 TC 16 100 30 30 30 30 30 10 10 TC 17 100 40 40 40 40 40 10 10 TC 18 100 50 50 50 50 50 10 10 TC 19 100 60 60 60 60 60 10 10

(Unit parts by weight, as other constituents, glycerin 105 parts by weight, xanthan gum 7 parts by weight, grapefruit seed extract 11 parts by weight, vitamin E 11 parts by weight, xylitol 50 parts by weight, vitamin C 42 parts by weight, calcium carbonate 320 parts by weight, Baking soda 53 parts by weight, silicon dioxide 105 parts by weight, propolis 10.5 parts by weight, apple surfactant 53 parts by weight, cocobetamine 32 parts by weight and peppermint essential oil 0.1 parts by weight)

[Experimental Example 1: Evaluation of the effect of reducing bad breath]

Bad breath test (BB Checker)

Bad breath measurement was performed using a BB Checker (mBA-21, Plustech, Korea), a device that comprehensively measures various bad breath gases in the oral cavity including volatile sulfur compounds (VSC). The BB Checker measurement method is as follows.

① Press the OG (Oral Gas) button, and the pre-preparation countdown of 180 seconds starts on the screen. ② When the countdown remains about 30 seconds, take out the Probe and insert it into a paper tube (Mouth piece). ③ When the pre-preparation countdown begins, hold the paper-crowned furb in your mouth. ④ Explain to breathe through the nose for 15 seconds and stop breathing. ⑤ When measurement is finished, read and record the measured value printed out by automatic printing.

Measure using BB Checker before brushing your teeth and 1 hour after using the detergent used in the experiment. The reading criteria were interpreted as normal (0-50 BBV), slightly bad breath feeling (50-70 BBV), somewhat severe symptom management need (70-90 BBV), and severe bad breath (90-100 BBV).

The experiment was conducted with 20 subjects, and the measurement was performed before and 1 hour after using the detergent. In order to increase the accuracy of the measurement, the same person was provided with the same meal after 6 hours, and the results measured before and after 1 hour after brushing using a detergent are shown in Table 3 below.

Before brushing 1 hour later TI 1 #One 44.70±13.87 47.50±21.86 #2 33.60±9.66 30.20±8.75 TC 1 #One 34.00±4.57 36.40±9.38 #2 30.50±7.93 25.50±11.01 TC 2 #One 35.17±14.51 35.50±8.15 #2 29.00±8.95 28.33±9.44 TC 3 #One 34.00±5.57 36.20±8.38 #2 30.70±7.63 27.50±11.21 TC 4 #One 33.40±6.17 32.20±8.38 #2 29.70±7.53 27.40±10.21 TC 5 #One 34.00±5.87 33.20±8.38 #2 31.70±7.63 29.50±11.21 TC 6 #One 38.00±5.87 39.20±1.38 #2 36.70±5.63 33.50±9.21 TC 7 #One 28.20±6.87 29.20±6.38 #2 31.70±7.63 29.25±11.21 TC 8 #One 31.01±4.87 30.20±4.38 #2 31.40±7.61 27.50±7.21 TC 9 #One 31.40±5.87 32.20±8.38 #2 31.70±6.63 28.50±7.21 TC 10 #One 33.10±7.87 33.10±6.38 #2 31.50±7.63 30.50±8.21 TC 11 #One 34.20±5.87 34.25±3.38 #2 31.70±8.63 30.50±10.21 TC 12 #One 33.52±4.67 33.20±4.38 #2 30.70±6.63 29.89±10.21 TC 13 #One 34.00±5.87 33.20±8.38 #2 30.70±7.63 29.52±11.21 TC 14 #One 34.00±5.87 33.20±8.38 #2 31.70±7.63 29.50±11.21 TC 15 #One 41.21±7.87 40.20±8.38 #2 36.70±5.63 35.51±8.21 TC 16 #One 33.21±5.87 30.20±4.38 #2 32.70±5.63 28.50±3.21 TC 17 #One 40.20±5.87 34.20±3.38 #2 33.70±5.63 28.50±4.21 TC 18 #One 38.00±4.87 30.21±3.38 #2 32.70±4.63 27.50±3.21 TC 19 #One 33.21±5.87 31.20±5.38 #2 32.62±4.63 29.50±4.21

According to Tables 3 to 5, it was confirmed that TC 1 to 19 had excellent bad breath reduction effect compared to TI 1 that did not contain a natural extract. In addition, in the case of TC 16 to 19, it was confirmed that if purified water was additionally included, the effect of reducing bad breath was further increased.

[Experimental Example 2: Evaluation of changes in pH of saliva]

The experiment was conducted on 20 subjects, and after having the subject chew the paraffin wax for 1 minute using the Dentobuff Strip, drop the obtained irritating saliva on the test paper with a pipette, wait for the reaction for 5 minutes, and then wait for the test paper. The color change of was observed. According to the guidelines of the Dentobuff Strip, blue is high-grade saliva buffering capacity (PH. 6.5 or higher), green is moderate salivary buffering capacity (PH. It was determined as.

pH TI 1 8.80±2.35 TC 1 9.00±2.93 TC 2 9.01±1.53 TC 3 9.03±2.43 TC 4 9.10±1.13 TC 5 9.08±1.63 TC 6 9.09±1.03 TC 7 9.11±1.23 TC 8 9.12±1.13 TC 9 9.05±1.93 TC 10 9.04±1.91 TC 11 9.08±2.93 TC 12 9.10±1.53 TC 13 9.07±1.61 TC 14 9.06±1.83 TC 15 9.07±2.93 TC 16 9.19±1.15 TC 17 9.28±1.30 TC 18 9.70±2.15 TC 19 9.32±1.35

When the pH is low, it is close to acid, which helps to deposit plaque, which is prone to dental caries or periodontal disease. However, most of the toothpastes on the market are neutral or alkaline.

The students who participated in the experiment were female students in their early twenties. Overall, the pH was neutral or weakly alkaline, but TC 1 to 19 were more likely to be alkaline compared to TI 1 that did not contain natural extracts. In addition, in the case of TC 16 to 19, when purified water is additionally included, the alkalinity of saliva is further increased, and it can be expected that the effect of preventing periodontal disease is excellent.

[Experimental Example 2: Sensory evaluation]

The composition for reducing bad breath and preventing periodontal disease of TC 1 to 19 and TI 1 was divided into groups of 15 people by targeting 30 randomly, and the first group was to use the composition for reducing bad breath and preventing periodontal disease of TC 1 to 15. And, the second group was made to use the composition for reducing bad breath and preventing periodontal disease of TC 13 to 19 and TI 1, and then evaluated for the contents of the questionnaire shown in Table 6 below. The higher the score, the better the evaluation.

Survey content 1. Less dry mouth 2. I feel refreshed 3. My mouth is not sticky. 4. The tooth color feels bright. 5. The gum inflammation seems to have improved. 6. The surface of the tooth seems to be smooth. 7. It seems to be effective in whitening teeth.

Questionnaire 1 Question 2 Question 3 Question 4 Question 5 Question 6 Question 7 TC 1 10 5 8 5 3 8 5 TC 2 10 5 8 5 4 7 5 TC 3 10 6 8 6 4 8 5 TC 4 10 4 8 5 3 8 5 TC 5 10 5 7 4 3 8 6 TC 6 10 6 8 6 3 8 5 TC 7 9 5 7 5 2 7 5 TC 8 9 5 7 5 3 7 5 TC 9 10 5 7 4 3 6 4 TC 10 9 4 7 4 3 6 4 TC 11 10 7 7 4 3 7 4 TC 12 9 4 7 4 3 6 4 TC 13 10 5 7 4 3 6 4 TC 14 9 6 8 4 4 6 5 TC 15 10 4 8 4 3 8 5

Questionnaire 1 Question 2 Question 3 Question 4 Question 5 Question 6 Question 7 TC 16 10 7 8 8 5 9 8 TC 17 10 7 8 9 4 10 7 TC 18 10 7 7 8 5 9 8 TC 19 10 8 8 8 5 9 8 TI 1 8 6 8 5 5 8 5

Table 7 shows the evaluation scores of the first group, and Table 8 shows the evaluation scores of the second group. The first and second groups were distinguished according to whether or not purified water was included in the composition for reducing bad breath and preventing periodontal disease.According to the results shown in Tables 7 and 8, reduction of bad breath and prevention of periodontal disease According to whether or not purified water was included in the composition, there was a difference in sensory evaluation results, and the composition for reducing bad breath and preventing periodontal disease of TC 16 to 19 received better evaluation.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements by those skilled in the art using the basic concept of the present invention defined in the following claims are also present. It belongs to the scope of rights of

Claims (11)

A composition for reducing bad breath and preventing periodontal disease, including natural extracts and purified water,
The natural extracts are dermis extract, strawberry extract, mortar extract, lemon extract, pine needle extract, mortar powder and mountain birch leaf powder,
With respect to 100 parts by weight of the purified water, 30 to 60 parts by weight of dermis extract, 30 to 60 parts by weight of strawberry extract, 30 to 60 parts by weight of mortar extract, 30 to 60 parts by weight of lemon extract, 30 to 60 parts by weight of pine needle extract, mortar powder Including 1 to 10 parts by weight and 1 to 10 parts by weight of mountain birch leaf powder,
It further contains grapefruit seed extract as a preservative,
The grapefruit seed extract comprises 11 parts by weight of grapefruit seed extract based on 100 parts by weight of the purified water
Composition for reducing bad breath and preventing periodontal disease, including natural extracts. delete delete delete The method of claim 1,
The composition for reducing bad breath and preventing periodontal disease further comprises xylitol, peppermint essential oil, vegetable glycerin, an abrasive and a thickener
Composition for reducing bad breath and preventing periodontal disease, including natural extracts. A toothpaste for reducing bad breath and preventing periodontal disease, including a composition for reducing bad breath and preventing periodontal disease, including the natural extract according to claim 1. An oral freshener for reducing bad breath and preventing periodontal disease, comprising a composition for reducing bad breath and preventing periodontal disease, including the natural extract according to claim 1. delete delete delete delete

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