CN112089680A - Effervescent tablet for self-made mouthwash - Google Patents
Effervescent tablet for self-made mouthwash Download PDFInfo
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- CN112089680A CN112089680A CN201910468475.6A CN201910468475A CN112089680A CN 112089680 A CN112089680 A CN 112089680A CN 201910468475 A CN201910468475 A CN 201910468475A CN 112089680 A CN112089680 A CN 112089680A
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- oral
- sodium
- acid
- lactobacillus
- effervescent
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- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 25
- 239000002324 mouth wash Substances 0.000 title claims abstract description 18
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 18
- 210000000214 mouth Anatomy 0.000 claims abstract description 22
- 239000006041 probiotic Substances 0.000 claims abstract description 21
- 235000018291 probiotics Nutrition 0.000 claims abstract description 21
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 claims abstract description 18
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 13
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 13
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 13
- 208000025157 Oral disease Diseases 0.000 claims abstract description 9
- 208000030194 mouth disease Diseases 0.000 claims abstract description 9
- 206010061218 Inflammation Diseases 0.000 claims abstract description 8
- 230000006378 damage Effects 0.000 claims abstract description 8
- 230000004054 inflammatory process Effects 0.000 claims abstract description 8
- 239000002131 composite material Substances 0.000 claims abstract description 7
- 230000012010 growth Effects 0.000 claims abstract description 7
- 210000002200 mouth mucosa Anatomy 0.000 claims abstract description 7
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 5
- 208000014674 injury Diseases 0.000 claims abstract description 5
- 238000004140 cleaning Methods 0.000 claims abstract description 3
- 241000894006 Bacteria Species 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 claims description 8
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 7
- 229940041616 menthol Drugs 0.000 claims description 7
- 241000186660 Lactobacillus Species 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 229940039696 lactobacillus Drugs 0.000 claims description 6
- 208000002064 Dental Plaque Diseases 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 239000003513 alkali Substances 0.000 claims description 4
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical class [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 229910001385 heavy metal Inorganic materials 0.000 claims description 4
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- 230000000529 probiotic effect Effects 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 229950002760 sodium gualenate Drugs 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 241000186000 Bifidobacterium Species 0.000 claims description 3
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 3
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 3
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- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 3
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 3
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 3
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 3
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims description 3
- 241000186869 Lactobacillus salivarius Species 0.000 claims description 3
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 3
- 229940017800 lactobacillus casei Drugs 0.000 claims description 3
- 229940012969 lactobacillus fermentum Drugs 0.000 claims description 3
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910052785 arsenic Inorganic materials 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000010338 boric acid Nutrition 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- -1 disodium glycerophosphate pentahydrate Chemical class 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 229960002350 guaiazulen Drugs 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 238000002834 transmittance Methods 0.000 claims description 2
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- 239000011707 mineral Substances 0.000 claims 1
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- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
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- 102000016943 Muramidase Human genes 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention provides an effervescent tablet for mouth wash, which can promote oral cavity cleaning, maintain oral flora balance, repair oral mucosa injury and inflammation and effectively prevent oral diseases, and the effervescent tablet comprises 5-20 parts of composite probiotics, 0.01-0.5 part of sodium azulene sulfonate, 0-0.5 part of mint and 79-95 parts of effervescent components. The components are uniformly mixed, and the effervescent tablet is prepared by tabletting by a conventional method. The effervescent tablet for mouthwash prepared by the invention is cool and analgesic, can effectively repair oral mucosa injury, has obvious effect of resisting oral inflammation, can effectively supplement oral probiotics, promotes oral flora balance, and can effectively inhibit propagation and growth of oral pathogenic bacteria. Has positive significance for oral health.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to a mouthwash effervescent tablet, in particular to a mouthwash effervescent tablet which has the functions of promoting oral cavity cleaning, maintaining oral flora balance, repairing oral mucosa injury and inflammation and effectively preventing oral diseases, and belongs to the field of daily necessities.
[ background of the invention ]
Oral health is an important public health problem affecting the quality of life of residents in China. Epidemiological investigation of oral health in China shows that caries (commonly known as tooth decay or tooth decay) and periodontal diseases (including gingivitis and periodontitis) are two of the most common diseases that harm oral health of residents in China. These oral diseases not only damage teeth and tissues around teeth, but also affect various functions of chewing, speech, beauty, and the like of the oral cavity. Moreover, with the continuous and intensive research, researchers also find that caries and periodontal diseases may cause or aggravate certain systemic diseases such as coronary heart disease, diabetes and the like, harm the health of the whole body and influence the quality of life. Therefore, it is important to maintain oral health and prevent oral diseases.
The infection of oral pathogenic bacteria is an important cause of oral diseases such as caries, periodontal disease and the like, and the species of bacteria in the oral cavity of a human body is more than 700. Similar to the intestinal flora, the oral flora of the human body is also in a dynamic equilibrium. However, once this balance is disrupted, it can trigger excessive growth of oral pathogens and thus compromise the health of the oral cavity, due to environmental changes or other oral conditions (e.g., quality of oral hygiene) in the individual.
At present, people deal with oral hygiene problems in life, and besides daily tooth brushing, the mouth wash with the antibacterial and bactericidal function is frequently used, however, the simple modes are far from enough. This is because oral pathogens colonize the biofilm, plaque, in the oral cavity. Dental plaque is a bacterial biofilm that cannot be washed away by water. The biological membrane provides a place for the growth and propagation of pathogenic bacteria in the oral cavity. Furthermore, the closed structure of dental plaque protects the pathogenic bacteria in dental plaque from external influences. Numerous studies have shown that oral bacteria in plaque are much less sensitive to bacteriostatic agents than when in a planktonic state. Oral bacteria are often pathogenic in the form of biofilms and are more resistant to most antibacterial agents, probably because of the difficulty in getting sufficient doses of antibacterial agents into the structure of the biofilm.
In recent years, more and more researches show that probiotics not only can regulate intestinal flora, but also can improve oral flora, thereby playing a positive role in the maintenance of oral health and the prevention and treatment of oral diseases. The probiotics such as lactobacillus can effectively inhibit the growth of oral pathogenic bacteria, and has the function of regulating oral flora. Further preventing periodontitis, dental caries, halitosis, etc. The oral cavity antibacterial mouthwash is also a serious defect of common antibacterial mouthwash, and the antibacterial bacteriostatic agents in the mouthwash can kill pathogenic bacteria in the oral cavity and probiotics in the oral cavity at the same time, so that the flora balance in the oral cavity is directly damaged, oral flora imbalance is caused, and the pathogenic bacteria easily occupy the dominant position to cause oral diseases. The invention aims at the problems of the prior common mouthwash, and provides a novel effervescent tablet for mouthwash, which comprises probiotics and sodium azulene sulfonate with good repairing effect specially on oral inflammation or mucosal injury. The invention is designed into effervescent tablets, and provides a portable, safe and sanitary new mouth rinsing way for people. The gargle brings convenience for people going on a business trip, a tour and the like, and avoids unnecessary troubles caused by carrying a large volume of gargle to take an airplane.
[ summary of the invention ]
The invention aims to provide a novel effervescent tablet for mouth wash, which can supplement oral probiotics and has the functions of repairing oral mucosa and promoting recovery of oral inflammation.
The main components of the mouthwash effervescent tablet consist of composite lactobacillus live bacteria, sodium azulene sulfonate and mint. A large amount of oral cavity probiotics, namely lactobacillus live bacteria, can supplement the oral cavity probiotics in time, help to adjust the balance of oral cavity flora and inhibit the occurrence of oral cavity diseases. Sodium azulene sulfonate: is prepared from pure natural chamomile extract, and has antibacterial, antiinflammatory, antiallergic and regeneration promoting effects. And is highly safe and is often used in foreign countries for the treatment and prevention of skin and oral diseases. Mint is pungent in flavor and cool in nature, and can dispel wind-heat, clear head and eyes, relieve sore throat, promote eruption, sooth liver and promote qi circulation. Can bring cool and refreshing feeling.
The effervescent tablet can repair oral mucosa, has obvious anti-inflammatory effect, and has obvious inhibition effect on oral inflammation, gingivitis, ulcer and the like.
The technical scheme is as follows:
the invention provides a novel effervescent tablet for mouth wash, which can supplement oral probiotics and has the functions of repairing oral mucosa and promoting recovery of oral inflammation. The effervescent tablet is realized by the following technical scheme, and the formula of the main components of the effervescent tablet comprises the following components in parts by weight:
the components in the formula are uniformly mixed and tabletted to prepare the effervescent tablet.
The composite probiotics provided by the invention are composite probiotics with special probiotic characteristics to oral cavities, which are composed of lactobacillus fermentum, bifidobacterium, lactobacillus plantarum, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus casei, lactobacillus siberian and the like, and each or any composite composition of the two or more.
The sodium azulene sulfonate disclosed by the invention has the following chemical name: sodium 1, 4-dimethyl-7-isopropylazulene-3-sulfonate, alternative name: sodium guaiazulene sulfonate, water-soluble Azulene, sodium guaranate, disodium glycerophosphate pentahydrate, AZ and Azulene. The name of English: sodium Guaiazulene Sulfonate or Sodium Azullene Sulfonate for short: and (9) SGS. CAS: 6223-35-4, purity of above 98%, biochemical or pharmaceutical grade. Has strong bioactivity, and has antibacterial, antiinflammatory, antiallergic and cell tissue regeneration promoting effects.
The mint of the invention is an extract of mint plants, called menthol, also called menthol, which is extracted from the leaves and stems of mint, has white crystals, molecular formula C10H200, and is the main component in mint and peppermint essential oil. It can be used as irritant in medicine, and has effects of refreshing, relieving itching, relieving sore throat, and promoting eruption.
The effervescent components of the invention refer to organic acid and alkali type (hydrogen) carbonate and other common medical auxiliary materials such as other common diluents, adhesives, lubricants and the like. When they dissolve in water, they undergo an effervescence reaction, i.e. release a large amount of carbon dioxide gas, like boiling. This class of components is herein collectively referred to as effervescent components.
The technical solution of the present invention is described in more detail further below:
further, the compound probiotics: lactobacillus fermentum, bifidobacterium, lactobacillus plantarum, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus casei and lactobacillus siberian are preferably strains with certain acid resistance, and because a certain amount of hydrogen peroxide, lysozyme and the like exist in the microenvironment of the oral cavity, the oral cavity probiotics have certain tolerance capability under the acidic condition so as to play the bacteriostatic and probiotic effects in the oral cavity. Furthermore, the probiotics can utilize the characteristics of the surrounding environment to enable the probiotics to have greater growth advantages in the environment with low pH value and can play a role in inhibiting bacteria more strongly. Further these are species which adhere, colonize and grow on the surface of salivary biofilm, etc. before they enter the plaque. Can fundamentally inhibit the growth of pathogenic bacteria.
Further, the sodium azulene sulfonate disclosed by the invention is preferably a product with the purity of more than 98%, and the higher the purity is, the higher the content of active ingredients is. The sodium azulene sulfonate can be of cosmetic grade or pharmaceutical grade, and is preferably of cosmetic grade. The heavy metal content in the further product is as follows: less than or equal to 20 ppm; the content of arsenic salt is less than or equal to 5 ppm; ultraviolet transmittance of guaiazulene: more than or equal to 95.0; insoluble matters in water: no residue remained on the filter paper. The product used by the invention is a product produced by Tianjin Shuichuo pharmaceutical industry Co.
Preferably, the menthol crystal disclosed by the invention is a food-grade transparent crystal, the content of the menthol crystal is more than 99%, the arsenic content is less than or equal to 3ppm, the lead content is less than or equal to 1ppm, the heavy metal content is less than or equal to 10ppm, and the menthol crystal disclosed by the invention is a commercial commodity.
The effervescent component is composed of a diluent, an adhesive, a disintegrating agent, a lubricant and other auxiliary materials, wherein the types of the diluent, the adhesive, the lubricant and the other auxiliary materials are the same as those of a common pharmaceutical tablet, the disintegrating agent used in the effervescent tablet is an effervescent disintegrating agent, the effervescent disintegrating agent comprises an acid source and an alkali source, and the common acid source comprises citric acid, malic acid, boric acid, tartaric acid, fumaric acid, inorganic mineral acid (hydrochloric acid) and the like; common sources of alkalinity are sodium bicarbonate, sodium carbonate and mixtures of the two.
[ detailed description ] embodiments
For further illustration of the objects, technical solutions and advantages of the present invention, we shall describe the present invention by referring to the following specific examples, which are only for better describing the patent of the present invention and not for limiting the scope of the present invention, and all other embodiments obtained by those skilled in the art without making any inventive changes are within the scope of the present invention based on the examples of the present invention. The experimental methods in the examples, in which specific conditions are not specified, are generally performed according to conventional conditions.
Example 1 (hereinafter, all parts by weight)
The effervescent tablets can be prepared by uniformly mixing the raw materials and directly pressing the mixture into tablets.
Example 2
The effervescent tablets can be prepared by uniformly mixing the raw materials and directly pressing the mixture into tablets.
Example 3
The effervescent tablets can be prepared by uniformly mixing the raw materials and directly pressing the mixture into tablets.
Evaluation of the effects:
to evaluate the effect of the present invention, effervescent tablets of mouthwash prepared according to example 2 of the present invention were administered to a total of 150 patients suffering from oral ulcer, gingivitis, periodontitis, halitosis, etc., and the effect was counted after 7 days and 15 days of administration.
| Time of use | Show effect | Is effective | Invalidation |
| It is used for 7 days | 112 | 32 | 0 |
| It is used for 15 days | 150 | 0 |
Trial and research shows that the mouthwash effervescent tablet disclosed by the invention has good effects on dental ulcer, gingivitis and halitosis, has a positive promotion effect on inflammation of periodontitis, and has an obvious effect.
Tests show that the novel nursing lotion has excellent antibacterial and anti-inflammatory functions, can effectively promote healing and regeneration of cell tissues, has a good effect of improving injured mucosal ulcers, can eliminate swelling and pain, detoxicate and promote tissue regeneration, can also adjust secretion of body fluid of a human body, and can promote functional recovery of a reproductive system of the human body. And mild skin-friendly tea saponin and amino acid surfactant are adopted, so that the composition has an antiallergic effect. Is especially suitable for people with active sexual life to maintain and clean everyday. The effect is excellent.
Claims (10)
1. An effervescent tablet for mouth wash, which can promote oral cavity cleaning, maintain oral cavity flora balance, repair oral mucosa injury and inflammation and effectively prevent oral diseases, is realized by the following technical scheme, and the effervescent tablet comprises the following main components (in parts by weight):
2. the composite probiotic bacteria of claim 1, wherein the composite probiotic bacteria comprise one or more of lactobacillus fermentum, bifidobacterium, lactobacillus plantarum, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus acidophilus, lactobacillus casei, lactobacillus siberian, and the like in any proportion.
3. The complex probiotics as claimed in claim 2, wherein the probiotics are acid-resistant bacteria, have greater growth advantage in low PH environment, and have stronger adhesion on the surface of dental plaque and saliva biofilm.
4. Sodium azulene sulfonate according to claim 1, chemical name: sodium 1, 4-dimethyl-7-isopropylazulene-3-sulfonate, alternative name: sodium guaiazulene sulfonate, water-soluble Azulene, sodium guaranate, disodium glycerophosphate pentahydrate, AZ and Azulene. The name of English: sodium Guaiazulene Sulfonate or Sodium Azullene Sulfonate for short: and (9) SGS. CAS: 6223-35-4, and is characterized by a product having a purity of 98% or more.
5. Sodium azulene sulfonate according to claim 4, characterized in that it may be of cosmetic or pharmaceutical grade, preferably of cosmetic grade.
6. The sodium azulene sulfonate according to claim 5, characterized in that the heavy metal content in the product is: less than or equal to 20 ppm; the content of arsenic salt is less than or equal to 5 ppm; ultraviolet transmittance of guaiazulene: more than or equal to 95.0; insoluble matters in water: no residue remained on the filter paper.
7. The mint of claim 1, wherein the mint is an extract of the mint plant, menthol, also known as menthol, extracted from the leaves and stems of mint, white crystals of formula C10H20O。
8. The mint of claim 7, wherein the mint is characterized by food grade, transparent crystals with a content of 99% or more, arsenic content of 3ppm or less, lead content of 1ppm or less, and heavy metal content of 10ppm or less.
9. The effervescent composition as claimed in claim 1 is effervescent disintegrant comprising organic acid and alkali (hydrogen) carbonate, and other common medicinal adjuvants such as diluent, binder, lubricant, etc.
10. The effervescent disintegrant comprised by the effervescent composition of claim 9 comprises an acid source and an alkali source, commonly used acid sources are citric acid, malic acid, boric acid, tartaric acid, fumaric acid, mineral acid (hydrochloric acid), and the like; common sources of alkalinity are sodium bicarbonate, sodium carbonate and mixtures of the two.
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| CN113144002A (en) * | 2021-03-15 | 2021-07-23 | 北京亿康倍尔生物科技有限公司 | Probiotic composition for maintaining oral health and application thereof |
| CN114027505A (en) * | 2021-11-09 | 2022-02-11 | 仙乐健康科技股份有限公司 | Effervescent tablet for buccal administration in oral cavity |
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| US7815897B1 (en) * | 2003-12-22 | 2010-10-19 | Amerilab Technologies, Inc. | Therapeutic effervescent composition |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
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| CN113144002A (en) * | 2021-03-15 | 2021-07-23 | 北京亿康倍尔生物科技有限公司 | Probiotic composition for maintaining oral health and application thereof |
| CN114027505A (en) * | 2021-11-09 | 2022-02-11 | 仙乐健康科技股份有限公司 | Effervescent tablet for buccal administration in oral cavity |
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